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1. IDEAL monitoring of musical skills during awake craniotomy: From step 1 to step 2

Author

Ferrier, C H, Ruis, C, Zadelhoff, D, Robe, P A J T, van Zandvoort, M J E, Ferrier, C H, Ruis, C, Zadelhoff, D, Robe, P A J T, and van Zandvoort, M J E

Abstract

The aim of awake brain surgery is to perform a maximum resection on the one hand, and to preserve cognitive functions, quality of life and personal autonomy on the other hand. Historically, language and sensorimotor functions were most frequently monitored. Over the years other cognitive functions, including music, have entered the operation theatre. Cases about monitoring musical abilities during awake brain surgery are emerging, and a systematic method how to monitor music would be the next step. According to the IDEAL framework for surgical innovations our study aims to present future recommendation based on a systematic literature search (PRISMA) in combination with lessons learned from three case reports from our own clinical practice with professional musicians (n = 3). We plead for structured procedures including individual tailored tasks. By embracing these recommendations, we can both improve clinical care and unravel music functions in the brain.

Published
2024

2. T2-FLAIR Mismatch: An Imaging Biomarker for Children's MYB/MYBL1-Altered Diffuse Astrocytoma or Angiocentric Glioma.

Author

MS Radiologie, Cancer, Circulatory Health, Brain, Pathologie Pathologen staf, PMC Medisch specialisten, Neurochirurgen, Neurochirurgie, Neurologen, PMC Research, Klinisch Verloskundigen, van Maren, E A, Dankbaar, J W, Wesseling, P, Plasschaert, S, Muhlebner, A, Hoving, E W, Robe, P A, Snijders, T J, Hoogendijk, R, Kranendonk, M E G, Lequin, M H, MS Radiologie, Cancer, Circulatory Health, Brain, Pathologie Pathologen staf, PMC Medisch specialisten, Neurochirurgen, Neurochirurgie, Neurologen, PMC Research, Klinisch Verloskundigen, van Maren, E A, Dankbaar, J W, Wesseling, P, Plasschaert, S, Muhlebner, A, Hoving, E W, Robe, P A, Snijders, T J, Hoogendijk, R, Kranendonk, M E G, and Lequin, M H

Published
2024

3. Diffuse, IDH-wildtype gliomas in adults with minimal histological change and isolated TERT promoter mutation: not simply CNS WHO grade 4

Author

Pathologie Opleiding, Neurologen, Brain, Cancer, Neurochirurgie, Pathologie Pathologen staf, Priesterbach-Ackley, L P, Cordier, F, de Witt Hamer, P, Snijders, T J, Robe, P A, Küsters, B, de Leng, W W J, den Dunnen, W F A, Brandsma, D, Jansen, C, Wesseling, P, Muhlebner, A, Pathologie Opleiding, Neurologen, Brain, Cancer, Neurochirurgie, Pathologie Pathologen staf, Priesterbach-Ackley, L P, Cordier, F, de Witt Hamer, P, Snijders, T J, Robe, P A, Küsters, B, de Leng, W W J, den Dunnen, W F A, Brandsma, D, Jansen, C, Wesseling, P, and Muhlebner, A

Published
2024

5. IDEAL monitoring of musical skills during awake craniotomy: From step 1 to step 2

Author

Leerstoel Zandvoort, Experimental Psychology (onderzoeksprogramma PF), Helmholtz Institute, Ferrier, C H, Ruis, C, Zadelhoff, D, Robe, P A J T, van Zandvoort, M J E, Leerstoel Zandvoort, Experimental Psychology (onderzoeksprogramma PF), Helmholtz Institute, Ferrier, C H, Ruis, C, Zadelhoff, D, Robe, P A J T, and van Zandvoort, M J E

Published
2024

7. Awake craniotomy does not lead to increased psychological complaints

Author

Wajer, I M C Huenges, Kal, J, Robe, P A, van Zandvoort, M J E, Ruis, C, Wajer, I M C Huenges, Kal, J, Robe, P A, van Zandvoort, M J E, and Ruis, C

Abstract

BACKGROUND: Patients with brain tumours are increasingly treated by using the awake craniotomy technique. Some patients may experience anxiety when subjected to brain surgery while being fully conscious. However, there has been only limited research into the extent to which such surgeries actually result in anxiety or other psychological complaints. Previous research suggests that undergoing awake craniotomy surgery does not lead to psychological complaints, and that post-traumatic stress disorders (PTSD) are uncommon following this type of surgery. It must be noted, however, that many of these studies used small random samples.METHOD: In the current study, 62 adult patients completed questionnaires to identify the degree to which they experienced anxiety, depressive and post-traumatic stress complaints following awake craniotomy using an awake-awake-awake procedure. All patients were cognitively monitored and received coaching by a clinical neuropsychologist during the surgery.RESULTS: In our sample, 21% of the patients reported pre-operative anxiety. Four weeks after surgery, 19% of the patients reported such complaints, and 24% of the patients reported anxiety complaints after 3 months. Depressive complaints were present in 17% (pre-operative), 15% (4 weeks post-operative) and 24% (3 months post-operative) of the patients. Although there were some intra-individual changes (improvement or deterioration) in the psychological complaints over time, on group-level postoperative levels of psychological complaints were not increased relative to the preoperative level of complaints. The severity of post-operative PTSD-related complaints were rarely suggestive of a PTSD. Moreover, these complaints were seldom attributed to the surgery itself, but appeared to be more related to the discovery of the tumour and the postoperative neuropathological diagnosis.CONCLUSIONS: The results of the present study do not indicate that undergoing awake craniotomy i

Published
2023

8. A timeline of cognitive functioning in glioma patients who undergo awake brain tumor surgery

Author

de Sain, A M, Mantione, M H M, Wajer, I M C Huenges, van Zandvoort, M J E, Willems, P W A, Robe, P A, Ruis, C, de Sain, A M, Mantione, M H M, Wajer, I M C Huenges, van Zandvoort, M J E, Willems, P W A, Robe, P A, and Ruis, C

Abstract

BACKGROUND: The purpose of awake brain tumor surgery is to maximize the resection of the tumor and to minimize the risk of neurological and cognitive impairments. The aim of this study is to gain understanding of the development of possible postoperative cognitive deficits after awake brain tumor surgery in patients with suspected gliomas, by comparing preoperative, early postoperative, and late postoperative functioning. A more detailed timeline will be helpful in informing candidates for surgery about what to expect regarding their cognitive functioning.METHODS: Thirty-seven patients were included in this study. Cognitive functioning was measured by means of a broad cognitive screener preoperatively, days after surgery and months after surgery in patients who underwent awake brain tumor surgery with cognitive monitoring. The cognitive screener included tests for object naming, reading, attention span, working memory, inhibition, inhibition/switching, and visuoperception. We performed a Friedman ANOVA to analyze on group level.RESULTS: Overall, no significant differences were found between preoperative cognitive functioning, early postoperative cognitive functioning, and late postoperative cognitive functioning, except for performances on the inhibition task. Directly after surgery, patients were significantly slower on this task. However, in the following months after surgery, they returned to their preoperative level.CONCLUSION: The timeline of cognitive functioning after awake tumor surgery appeared overall stable in the early and late postoperative phase, except for inhibition, which is more difficult in the first days after awake brain tumor surgery. This more detailed timeline of cognitive functioning, in combination with future research, can possibly be contributing in informing patients and caregivers what to expect after awake brain tumor surgery.

Published
2023

9. Awake craniotomy does not lead to increased psychological complaints

Author

Leerstoel Zandvoort, Experimental Psychology (onderzoeksprogramma PF), Helmholtz Institute, Wajer, I M C Huenges, Kal, J, Robe, P A, van Zandvoort, M J E, Ruis, C, Leerstoel Zandvoort, Experimental Psychology (onderzoeksprogramma PF), Helmholtz Institute, Wajer, I M C Huenges, Kal, J, Robe, P A, van Zandvoort, M J E, and Ruis, C

Published
2023

10. A timeline of cognitive functioning in glioma patients who undergo awake brain tumor surgery

Author

Experimental Psychology (onderzoeksprogramma PF), Helmholtz Institute, Leerstoel Smagt, Leerstoel Zandvoort, de Sain, A M, Mantione, M H M, Wajer, I M C Huenges, van Zandvoort, M J E, Willems, P W A, Robe, P A, Ruis, C, Experimental Psychology (onderzoeksprogramma PF), Helmholtz Institute, Leerstoel Smagt, Leerstoel Zandvoort, de Sain, A M, Mantione, M H M, Wajer, I M C Huenges, van Zandvoort, M J E, Willems, P W A, Robe, P A, and Ruis, C

Published
2023

11. A timeline of cognitive functioning in glioma patients who undergo awake brain tumor surgery: a response to Mahajan et al. and their letter to the editor

Author

Leerstoel Zandvoort, Experimental Psychology (onderzoeksprogramma PF), Helmholtz Institute, de Sain, A M, van Zandvoort, M J E, Mantione, M H M, Huenges Wajer, I M C, Willems, P W A, Robe, P A, Ruis, C, Leerstoel Zandvoort, Experimental Psychology (onderzoeksprogramma PF), Helmholtz Institute, de Sain, A M, van Zandvoort, M J E, Mantione, M H M, Huenges Wajer, I M C, Willems, P W A, Robe, P A, and Ruis, C

Published
2023

12. A timeline of cognitive functioning in glioma patients who undergo awake brain tumor surgery

Author

Onderzoek NEU, Neurologie/Neurochirugie Zorg, Neurologie, Neuropsychologie, Neurochirurgen, Neurochirurgie, Brain, Cancer, de Sain, A M, Mantione, M H M, Wajer, I M C Huenges, van Zandvoort, M J E, Willems, P W A, Robe, P A, Ruis, C, Onderzoek NEU, Neurologie/Neurochirugie Zorg, Neurologie, Neuropsychologie, Neurochirurgen, Neurochirurgie, Brain, Cancer, de Sain, A M, Mantione, M H M, Wajer, I M C Huenges, van Zandvoort, M J E, Willems, P W A, Robe, P A, and Ruis, C

Published
2023

13. Awake craniotomy does not lead to increased psychological complaints

Author

Neurologie, Neuropsychologie, Neurochirurgie, Brain, Cancer, Wajer, I M C Huenges, Kal, J, Robe, P A, van Zandvoort, M J E, Ruis, C, Neurologie, Neuropsychologie, Neurochirurgie, Brain, Cancer, Wajer, I M C Huenges, Kal, J, Robe, P A, van Zandvoort, M J E, and Ruis, C

Published
2023

14. A timeline of cognitive functioning in glioma patients who undergo awake brain tumor surgery: a response to Mahajan et al. and their letter to the editor

Author

Onderzoek NEU, Neuropsychologie, Neurologie/Neurochirugie Zorg, Neurologie, Neurochirurgen, Neurochirurgie, Brain, Cancer, de Sain, A M, van Zandvoort, M J E, Mantione, M H M, Huenges Wajer, I M C, Willems, P W A, Robe, P A, Ruis, C, Onderzoek NEU, Neuropsychologie, Neurologie/Neurochirugie Zorg, Neurologie, Neurochirurgen, Neurochirurgie, Brain, Cancer, de Sain, A M, van Zandvoort, M J E, Mantione, M H M, Huenges Wajer, I M C, Willems, P W A, Robe, P A, and Ruis, C

Published
2023

15. The impact of etiology in lesion-symptom mapping - A direct comparison between tumor and stroke

Author

Neuropsychologie, Groep Timmers, Neurochirurgie, Projectafdeling functional imaging, Brain, VS-DIGD, Neurologie, Klinische Fysica RT, Cancer, MS Radiotherapie, Circulatory Health, Neurologen, van Grinsven, E E, Smits, A R, van Kessel, E, Raemaekers, M A H, de Haan, E H F, Huenges Wajer, I M C, Ruijters, V J, Philippens, M E P, Verhoeff, J J C, Ramsey, N F, Robe, P A J T, Snijders, T J, van Zandvoort, M J E, Neuropsychologie, Groep Timmers, Neurochirurgie, Projectafdeling functional imaging, Brain, VS-DIGD, Neurologie, Klinische Fysica RT, Cancer, MS Radiotherapie, Circulatory Health, Neurologen, van Grinsven, E E, Smits, A R, van Kessel, E, Raemaekers, M A H, de Haan, E H F, Huenges Wajer, I M C, Ruijters, V J, Philippens, M E P, Verhoeff, J J C, Ramsey, N F, Robe, P A J T, Snijders, T J, and van Zandvoort, M J E

Published
2023

16. Study protocol of the GLOW study: maximising treatment options for recurrent glioblastoma patients by whole genome sequencing-based diagnostics-a prospective multicenter cohort study

Author

Opijnen, M.P. van, Broekman, M.L., Vos, F.Y.F.L. de, Cuppen, E., Hoeven, J.J.M. van der, Linde, M.E. van, Compter, A., Beerepoot, L.V., Bent, M.J. van den, Vos, M.J. de, Fiebrich, H.B., Koekkoek, J.A.F., Hoeben, A., Kho, K.H., Driessen, C.M.L., Jeltema, H.R., Robe, P., Maas, S.L.N., Opijnen, M.P. van, Broekman, M.L., Vos, F.Y.F.L. de, Cuppen, E., Hoeven, J.J.M. van der, Linde, M.E. van, Compter, A., Beerepoot, L.V., Bent, M.J. van den, Vos, M.J. de, Fiebrich, H.B., Koekkoek, J.A.F., Hoeben, A., Kho, K.H., Driessen, C.M.L., Jeltema, H.R., Robe, P., and Maas, S.L.N.

Abstract

Contains fulltext : 287673.pdf (Publisher’s version ) (Open Access), BACKGROUND: Glioblastoma (GBM), the most common glial primary brain tumour, is without exception lethal. Every year approximately 600 patients are diagnosed with this heterogeneous disease in The Netherlands. Despite neurosurgery, chemo -and radiation therapy, these tumours inevitably recur. Currently, there is no gold standard at time of recurrence and treatment options are limited. Unfortunately, the results of dedicated trials with new drugs have been very disappointing. The goal of the project is to obtain the evidence for changing standard of care (SOC) procedures to include whole genome sequencing (WGS) and consequently adapt care guidelines for this specific patient group with very poor prognosis by offering optimal and timely benefit from novel therapies, even in the absence of traditional registration trials for this small volume cancer indication. METHODS: The GLOW study is a prospective diagnostic cohort study executed through collaboration of the Hartwig Medical Foundation (Hartwig, a non-profit organisation) and twelve Dutch centers that perform neurosurgery and/or treat GBM patients. A total of 200 patients with a first recurrence of a glioblastoma will be included. Dual primary endpoint is the percentage of patients who receive targeted therapy based on the WGS report and overall survival. Secondary endpoints include WGS report success rate and number of targeted treatments available based on WGS reports and number of patients starting a treatment in presence of an actionable variant. At recurrence, study participants will undergo SOC neurosurgical resection. Tumour material will then, together with a blood sample, be sent to Hartwig where it will be analysed by WGS. A diagnostic report with therapy guidance, including potential matching off-label drugs and available clinical trials will then be sent back to the treating physician for discussing of the results in molecular tumour boards and targeted treatment decision making. DISCUSSION: The GLOW stud

Published
2022

17. Study protocol of the GLOW study: maximising treatment options for recurrent glioblastoma patients by whole genome sequencing-based diagnostics-a prospective multicenter cohort study

Author

Opijnen, M.P. van, Broekman, M.L., Vos, F.Y.F.L. de, Cuppen, E., Hoeven, J.J.M. van der, Linde, M.E. van, Compter, A., Beerepoot, L.V., Bent, M.J. van den, Vos, M.J. de, Fiebrich, H.B., Koekkoek, J.A.F., Hoeben, A., Kho, K.H., Driessen, C.M.L., Jeltema, H.R., Robe, P., Maas, S.L.N., Opijnen, M.P. van, Broekman, M.L., Vos, F.Y.F.L. de, Cuppen, E., Hoeven, J.J.M. van der, Linde, M.E. van, Compter, A., Beerepoot, L.V., Bent, M.J. van den, Vos, M.J. de, Fiebrich, H.B., Koekkoek, J.A.F., Hoeben, A., Kho, K.H., Driessen, C.M.L., Jeltema, H.R., Robe, P., and Maas, S.L.N.

Abstract

Contains fulltext : 287673.pdf (Publisher’s version ) (Open Access), BACKGROUND: Glioblastoma (GBM), the most common glial primary brain tumour, is without exception lethal. Every year approximately 600 patients are diagnosed with this heterogeneous disease in The Netherlands. Despite neurosurgery, chemo -and radiation therapy, these tumours inevitably recur. Currently, there is no gold standard at time of recurrence and treatment options are limited. Unfortunately, the results of dedicated trials with new drugs have been very disappointing. The goal of the project is to obtain the evidence for changing standard of care (SOC) procedures to include whole genome sequencing (WGS) and consequently adapt care guidelines for this specific patient group with very poor prognosis by offering optimal and timely benefit from novel therapies, even in the absence of traditional registration trials for this small volume cancer indication. METHODS: The GLOW study is a prospective diagnostic cohort study executed through collaboration of the Hartwig Medical Foundation (Hartwig, a non-profit organisation) and twelve Dutch centers that perform neurosurgery and/or treat GBM patients. A total of 200 patients with a first recurrence of a glioblastoma will be included. Dual primary endpoint is the percentage of patients who receive targeted therapy based on the WGS report and overall survival. Secondary endpoints include WGS report success rate and number of targeted treatments available based on WGS reports and number of patients starting a treatment in presence of an actionable variant. At recurrence, study participants will undergo SOC neurosurgical resection. Tumour material will then, together with a blood sample, be sent to Hartwig where it will be analysed by WGS. A diagnostic report with therapy guidance, including potential matching off-label drugs and available clinical trials will then be sent back to the treating physician for discussing of the results in molecular tumour boards and targeted treatment decision making. DISCUSSION: The GLOW stud

Published
2022

18. Preoperative brain tumor imaging: models and software for segmentation and standardized reporting

Author

Bouget, D., Pedersen, A., Jakola, A. S., Kavouridis, V., Emblem, K. E., Eijgelaar, R. S., Kommers, I., Ardon, H., Barkhof, F., Bello, L., Berger, M. S., Nibali, M. C., Furtner, J., Hervey-Jumper, S., Idema, A. J. S., Kiesel, B., Kloet, A., Mandonnet, E., Müller, D. M. J., Robe, P. A., Rossi, M., Sciortino, T., Brink, W. Van den, Wagemakers, M., Widhalm, G., Witte, M. G., Zwinderman, A. H., Hamer, P. C. De Witt, Solheim, O., Reinertsen, I., Bouget, D., Pedersen, A., Jakola, A. S., Kavouridis, V., Emblem, K. E., Eijgelaar, R. S., Kommers, I., Ardon, H., Barkhof, F., Bello, L., Berger, M. S., Nibali, M. C., Furtner, J., Hervey-Jumper, S., Idema, A. J. S., Kiesel, B., Kloet, A., Mandonnet, E., Müller, D. M. J., Robe, P. A., Rossi, M., Sciortino, T., Brink, W. Van den, Wagemakers, M., Widhalm, G., Witte, M. G., Zwinderman, A. H., Hamer, P. C. De Witt, Solheim, O., and Reinertsen, I.

Abstract

For patients suffering from brain tumor, prognosis estimation and treatment decisions are made by a multidisciplinary team based on a set of preoperative MR scans. Currently, the lack of standardized and automatic methods for tumor detection and generation of clinical reports represents a major hurdle. In this study, we investigate glioblastomas, lower grade gliomas, meningiomas, and metastases, through four cohorts of up to 4000 patients. Tumor segmentation models were trained using the AGU-Net architecture with different preprocessing steps and protocols. Segmentation performances were assessed in-depth using a wide-range of voxel and patient-wise metrics covering volume, distance, and probabilistic aspects. Finally, two software solutions have been developed, enabling an easy use of the trained models and standardized generation of clinical reports: Raidionics and Raidionics-Slicer. Segmentation performances were quite homogeneous across the four different brain tumor types, with an average true positive Dice ranging between 80% and 90%, patient-wise recall between 88% and 98%, and patient-wise precision around 95%. With our Raidionics software, running on a desktop computer with CPU support, tumor segmentation can be performed in 16 to 54 seconds depending on the dimensions of the MRI volume. For the generation of a standardized clinical report, including the tumor segmentation and features computation, 5 to 15 minutes are necessary. All trained models have been made open-access together with the source code for both software solutions and validation metrics computation. In the future, an automatic classification of the brain tumor type would be necessary to replace manual user input. Finally, the inclusion of post-operative segmentation in both software solutions will be key for generating complete post-operative standardized clinical reports., Comment: 20 pages, 5 figures, 10 tables

Published
2022
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19. MR Imaging and Clinical Characteristics of Diffuse Glioneuronal Tumor with Oligodendroglioma-like Features and Nuclear Clusters

Author

Neurochirurgie, Brain, Cancer, MS Radiologie, Circulatory Health, Benesch, M, Perwein, T, Apfaltrer, G, Langer, T, Neumann, A, Brecht, I B, Schuhmann, M U, Cario, H, Frühwald, M C, Vollert, K, van Buiren, M, Deng, M Y, Seitz, A, Haberler, C, Mynarek, M, Kramm, C, Sahm, F, Robe, P A, Dankbaar, J W, Hoff, K V, Warmuth-Metz, M, Bison, B, Neurochirurgie, Brain, Cancer, MS Radiologie, Circulatory Health, Benesch, M, Perwein, T, Apfaltrer, G, Langer, T, Neumann, A, Brecht, I B, Schuhmann, M U, Cario, H, Frühwald, M C, Vollert, K, van Buiren, M, Deng, M Y, Seitz, A, Haberler, C, Mynarek, M, Kramm, C, Sahm, F, Robe, P A, Dankbaar, J W, Hoff, K V, Warmuth-Metz, M, and Bison, B

Published
2022

20. TUMOR CENTRALITY IS ASSOCIATED WITH A DECLINING OVERALL SURVIVAL IN IRRADIATED DIFFUSE GLIOMA

Author

Onderzoek Radiotherapie, Cancer, Orthopaedie Opleiding, Neurochirurgie, Brain, MS Radiotherapie, Van der Boog, A. T. J., David, S., Nagtegaal, S. H. J., Bruil, D. E., Cialdella, F., Snijders, T., Robe, P. A. J., Verhoeff, J. J. C., Onderzoek Radiotherapie, Cancer, Orthopaedie Opleiding, Neurochirurgie, Brain, MS Radiotherapie, Van der Boog, A. T. J., David, S., Nagtegaal, S. H. J., Bruil, D. E., Cialdella, F., Snijders, T., Robe, P. A. J., and Verhoeff, J. J. C.

Published
2022

22. CONVENTIONAL MRI CRITERIA DIFFERENTIATE TRUE TUMOUR PROGRESSION FROM TREATMENT-INDUCED EFFECTS IN IRRADIATED WHO GRADE 3 AND 4 GLIOMAS

Author

Onderzoek NCH, MS Radiotherapie, Cancer, MS Medische Oncologie, Neurologen, Neurochirurgie, Brain, Divisie Beeld, MS Radiologie, Circulatory Health, Flies, C. M., van Leuken, K. H., Verhoeff, J. J. C., de Vos, F. Y. F., Seute, T., Robe, P. A., Hendrikse, J., Witkamp, T. D., Dankbaar, J. W., Snijders, T. J., Onderzoek NCH, MS Radiotherapie, Cancer, MS Medische Oncologie, Neurologen, Neurochirurgie, Brain, Divisie Beeld, MS Radiologie, Circulatory Health, Flies, C. M., van Leuken, K. H., Verhoeff, J. J. C., de Vos, F. Y. F., Seute, T., Robe, P. A., Hendrikse, J., Witkamp, T. D., Dankbaar, J. W., and Snijders, T. J.

Published
2021

23. RELATION BETWEEN NEUROLOGICAL DEFICITS AND LOCATION OF POSTSURGICAL ISCHEMIA IN GLIOMA RESECTION

Author

Onderzoek Radiotherapie, Cancer, MS Radiologie, Brain, Circulatory Health, Neurologen, MS Radiotherapie, Neurochirurgie, van der Boog, A. T. J., David, S., Steennis, A. M. M., Dankbaar, J. W., Snijders, T. J., Verhoeff, J. J. C., Robe, P. A., Onderzoek Radiotherapie, Cancer, MS Radiologie, Brain, Circulatory Health, Neurologen, MS Radiotherapie, Neurochirurgie, van der Boog, A. T. J., David, S., Steennis, A. M. M., Dankbaar, J. W., Snijders, T. J., Verhoeff, J. J. C., and Robe, P. A.

Published
2021

24. VOXELWISE ANALYSIS OF SPATIAL DISTRIBUTION OF POSTOPERATIVE ISCHEMIA IN DIFFUSE GLIOMA

Author

Onderzoek Radiotherapie, Cancer, Neurologen, Brain, MS Radiologie, Circulatory Health, Neurochirurgie, MS Radiotherapie, van der Boog, A. T. J., David, S., Steennis, A. M. M., Snijders, T. J., Dankbaar, J. W., Robe, P. A., Verhoeff, J. J. C., Onderzoek Radiotherapie, Cancer, Neurologen, Brain, MS Radiologie, Circulatory Health, Neurochirurgie, MS Radiotherapie, van der Boog, A. T. J., David, S., Steennis, A. M. M., Snijders, T. J., Dankbaar, J. W., Robe, P. A., and Verhoeff, J. J. C.

Published
2021

25. Spatial Glioma Distribution and Development of Post-Radiation Injury: The Left Temporal Region

Author

Onderzoek Radiotherapie, Cancer, MS Radiologie, Brain, Circulatory Health, Neurologen, Neurochirurgie, MS Radiotherapie, van der Boog, A. T.J., David, S., Steennis, A. M.M., Dankbaar, J. W., Snijders, T., Robe, P., Verhoeff, J., Onderzoek Radiotherapie, Cancer, MS Radiologie, Brain, Circulatory Health, Neurologen, Neurochirurgie, MS Radiotherapie, van der Boog, A. T.J., David, S., Steennis, A. M.M., Dankbaar, J. W., Snijders, T., Robe, P., and Verhoeff, J.

Published
2021

26. Tinnitus treatment by vagus nerve stimulation: A systematic review

Author

MS KNO, Brain, Neurochirurgie, Cancer, Zorgeenheid KNO Medisch, Other research (not in main researchprogram), Stegeman, I, Velde, H M, Robe, P A J T, Stokroos, R J, Smit, A L, MS KNO, Brain, Neurochirurgie, Cancer, Zorgeenheid KNO Medisch, Other research (not in main researchprogram), Stegeman, I, Velde, H M, Robe, P A J T, Stokroos, R J, and Smit, A L

Published
2021

27. The adult human subventricular zone: partial ependymal coverage and proliferative capacity of cerebrospinal fluid

Author

de Sonnaville, S, van Strien, M, Middeldorp, J, Sluijs, J, van den Berge, S, Moeton, M, Donega, V, van Berkel, A, Deering, T, De Filippis, L, Vescovi, A, Aronica, E, Glass, R, van de Berg, W, Swaab, D, Robe, P, Hol, E, de Sonnaville, Sophia F A M, van Strien, Miriam E, Middeldorp, Jinte, Sluijs, Jacqueline A, van den Berge, Simone A, Moeton, Martina, Donega, Vanessa, van Berkel, Annemiek, Deering, Tasmin, De Filippis, Lidia, Vescovi, Angelo L, Aronica, Eleonora, Glass, Rainer, van de Berg, Wilma D J, Swaab, Dick F, Robe, Pierre A, Hol, Elly M, de Sonnaville, S, van Strien, M, Middeldorp, J, Sluijs, J, van den Berge, S, Moeton, M, Donega, V, van Berkel, A, Deering, T, De Filippis, L, Vescovi, A, Aronica, E, Glass, R, van de Berg, W, Swaab, D, Robe, P, Hol, E, de Sonnaville, Sophia F A M, van Strien, Miriam E, Middeldorp, Jinte, Sluijs, Jacqueline A, van den Berge, Simone A, Moeton, Martina, Donega, Vanessa, van Berkel, Annemiek, Deering, Tasmin, De Filippis, Lidia, Vescovi, Angelo L, Aronica, Eleonora, Glass, Rainer, van de Berg, Wilma D J, Swaab, Dick F, Robe, Pierre A, and Hol, Elly M

Abstract

Neurogenesis continues throughout adulthood in specialized regions of the brain. One of these regions is the subventricular zone. During brain development, neurogenesis is regulated by a complex interplay of intrinsic and extrinsic cues that control stem-cell survival, renewal and cell lineage specification. Cerebrospinal fluid (CSF) is an integral part of the neurogenic niche in development as it is in direct contact with radial glial cells, and it is important in regulating proliferation and migration. Yet, the effect of CSF on neural stem cells in the subventricular zone of the adult human brain is unknown. We hypothesized a persistent stimulating effect of ventricular CSF on neural stem cells in adulthood, based on the literature, describing bulging accumulations of subventricular cells where CSF is in direct contact with the subventricular zone. Here, we show by immunohistochemistry on post-mortem adult human subventricular zone sections that neural stem cells are in close contact with CSF via protrusions through both intact and incomplete ependymal layers. We are the first to systematically quantify subventricular glial nodules denuded of ependyma and consisting of proliferating neural stem and progenitor cells, and showed that they are present from foetal age until adulthood. Neurosphere, cell motility and differentiation assays as well as analyses of RNA expression were used to assess the effects of CSF of adult humans on primary neural stem cells and a human immortalized neural stem cell line. We show that human ventricular CSF increases proliferation and decreases motility of neural stem cells. Our results also indicate that adult CSF pushes neural stem cells from a relative quiescent to a more active state and promotes neuronal over astrocytic lineage differentiation. Thus, CSF continues to stimulate neural stem cells throughout aging.

Published
2020

28. Grading of meningeal solitary fibrous tumors/hemangiopericytomas: analysis of the prognostic value of the Marseille Grading System in a cohort of 132 patients

Author

Macagno, Nicolas, Vogels, Rob, Appay, Romain, Colin, Carole, Mokhtari, Karima, Bouvier, Corinne, Cornu, Philippe, Dufour, Henry, Figarella-Branger, Dominique, Guyotat, Jacques, Jouvet, Anne, Metellus, Philippe, Vasiljevic, Alexandre, Varlet, Pascale, Vogels, R., Flucke, U., Kusters, B., Groenen, P., Wesseling, P., Bekers, E., Verdijk, M., Djafarihamedani, M., Kurt, E., Kusters-Vandevelde, H., Fleischeuer, R., Leenstra, S., Robe, P., Spliet, W., Troost, D., van Furth, W., Kusters, Benno, Macagno, Nicolas, Vogels, Rob, Appay, Romain, Colin, Carole, Mokhtari, Karima, Bouvier, Corinne, Cornu, Philippe, Dufour, Henry, Figarella-Branger, Dominique, Guyotat, Jacques, Jouvet, Anne, Metellus, Philippe, Vasiljevic, Alexandre, Varlet, Pascale, Vogels, R., Flucke, U., Kusters, B., Groenen, P., Wesseling, P., Bekers, E., Verdijk, M., Djafarihamedani, M., Kurt, E., Kusters-Vandevelde, H., Fleischeuer, R., Leenstra, S., Robe, P., Spliet, W., Troost, D., van Furth, W., and Kusters, Benno

Published
2019

29. Grading of meningeal solitary fibrous tumors/hemangiopericytomas: analysis of the prognostic value of the Marseille Grading System in a cohort of 132 patients

Author

Macagno, Nicolas, Vogels, Rob, Appay, Romain, Colin, Carole, Mokhtari, Karima, Bouvier, Corinne, Cornu, Philippe, Dufour, Henry, Figarella-Branger, Dominique, Guyotat, Jacques, Jouvet, Anne, Metellus, Philippe, Vasiljevic, Alexandre, Varlet, Pascale, Vogels, R., Flucke, U., Kusters, B., Groenen, P., Wesseling, P., Bekers, E., Verdijk, M., Djafarihamedani, M., Kurt, E., Kusters-Vandevelde, H., Fleischeuer, R., Leenstra, S., Robe, P., Spliet, W., Troost, D., van Furth, W., Kusters, Benno, Macagno, Nicolas, Vogels, Rob, Appay, Romain, Colin, Carole, Mokhtari, Karima, Bouvier, Corinne, Cornu, Philippe, Dufour, Henry, Figarella-Branger, Dominique, Guyotat, Jacques, Jouvet, Anne, Metellus, Philippe, Vasiljevic, Alexandre, Varlet, Pascale, Vogels, R., Flucke, U., Kusters, B., Groenen, P., Wesseling, P., Bekers, E., Verdijk, M., Djafarihamedani, M., Kurt, E., Kusters-Vandevelde, H., Fleischeuer, R., Leenstra, S., Robe, P., Spliet, W., Troost, D., van Furth, W., and Kusters, Benno

Published
2019

30. Grading of meningeal solitary fibrous tumors/hemangiopericytomas: analysis of the prognostic value of the Marseille Grading System in a cohort of 132 patients

Author

Macagno, Nicolas, Vogels, Rob, Appay, Romain, Colin, Carole, Mokhtari, Karima, Bouvier, Corinne, Cornu, Philippe, Dufour, Henry, Figarella-Branger, Dominique, Guyotat, Jacques, Jouvet, Anne, Metellus, Philippe, Vasiljevic, Alexandre, Varlet, Pascale, Vogels, R., Flucke, U., Kusters, B., Groenen, P., Wesseling, P., Bekers, E., Verdijk, M., Djafarihamedani, M., Kurt, E., Kusters-Vandevelde, H., Fleischeuer, R., Leenstra, S., Robe, P., Spliet, W., Troost, D., van Furth, W., Kusters, Benno, Macagno, Nicolas, Vogels, Rob, Appay, Romain, Colin, Carole, Mokhtari, Karima, Bouvier, Corinne, Cornu, Philippe, Dufour, Henry, Figarella-Branger, Dominique, Guyotat, Jacques, Jouvet, Anne, Metellus, Philippe, Vasiljevic, Alexandre, Varlet, Pascale, Vogels, R., Flucke, U., Kusters, B., Groenen, P., Wesseling, P., Bekers, E., Verdijk, M., Djafarihamedani, M., Kurt, E., Kusters-Vandevelde, H., Fleischeuer, R., Leenstra, S., Robe, P., Spliet, W., Troost, D., van Furth, W., and Kusters, Benno

Published
2019

31. Grading of meningeal solitary fibrous tumors/hemangiopericytomas: analysis of the prognostic value of the Marseille Grading System in a cohort of 132 patients

Author

Pathologie Pathologen staf, Neurochirurgie, Brain, Cancer, Macagno, Nicolas, Vogels, Rob, Appay, Romain, Colin, Carole, Mokhtari, Karima, Bouvier, Corinne, Cornu, Philippe, Dufour, Henry, Figarella-Branger, Dominique, Guyotat, Jacques, Jouvet, Anne, Metellus, Philippe, Vasiljevic, Alexandre, Varlet, Pascale, Vogels, R., Flucke, U., Kusters, B., Groenen, P., Wesseling, P., Bekers, E., Verdijk, M., Djafarihamedani, M., Kurt, E., Kusters-Vandevelde, H., Fleischeuer, R., Leenstra, S., Robe, P., Spliet, W., Troost, D., van Furth, W., Kusters, Benno, Pathologie Pathologen staf, Neurochirurgie, Brain, Cancer, Macagno, Nicolas, Vogels, Rob, Appay, Romain, Colin, Carole, Mokhtari, Karima, Bouvier, Corinne, Cornu, Philippe, Dufour, Henry, Figarella-Branger, Dominique, Guyotat, Jacques, Jouvet, Anne, Metellus, Philippe, Vasiljevic, Alexandre, Varlet, Pascale, Vogels, R., Flucke, U., Kusters, B., Groenen, P., Wesseling, P., Bekers, E., Verdijk, M., Djafarihamedani, M., Kurt, E., Kusters-Vandevelde, H., Fleischeuer, R., Leenstra, S., Robe, P., Spliet, W., Troost, D., van Furth, W., and Kusters, Benno

Published
2019

32. Between-hospital variation in mortality and survival after glioblastoma surgery in the Dutch Quality Registry for Neuro Surgery

Author

Hamer, PCD, Ho, VKY, Zwinderman, AH, Ackermans, L, Ardon, H, Boomstra, S, Bouwknegt, W, van den Brink, WA, Dirven, Clemens, van der Gaag, NA, van der Veer, O, Idema, AJS, Kloet, A, Koopmans, J, Laan, M, Verstegen, MJAM, Wagemakers, M, Robe, P, Hamer, PCD, Ho, VKY, Zwinderman, AH, Ackermans, L, Ardon, H, Boomstra, S, Bouwknegt, W, van den Brink, WA, Dirven, Clemens, van der Gaag, NA, van der Veer, O, Idema, AJS, Kloet, A, Koopmans, J, Laan, M, Verstegen, MJAM, Wagemakers, M, and Robe, P

Published
2019

33. miR-4516 is a Novel Prognostic Biomarker and Promotes Tumorigenesis via Targeting PTPN14-Mediated Regulation of the Hippo Pathway in Glioblastoma

Author

Cui, T., Bell, E. H., McElroy, J., Becker, A., Gulati, P., Geurts, M., Mladkova, N., Gray, A., Liu, K., Yang, L., Liu, Z., Fleming, J., Haque, S. J., Robe, P., Chakravarti, A., Cui, T., Bell, E. H., McElroy, J., Becker, A., Gulati, P., Geurts, M., Mladkova, N., Gray, A., Liu, K., Yang, L., Liu, Z., Fleming, J., Haque, S. J., Robe, P., and Chakravarti, A.

Published
2018

35. miR-4516 is a Novel Prognostic Biomarker and Promotes Tumorigenesis via Targeting PTPN14-Mediated Regulation of the Hippo Pathway in Glioblastoma

Author

Cui, T., Bell, E. H., McElroy, J., Becker, A., Gulati, P., Geurts, M., Mladkova, N., Gray, A., Liu, K., Yang, L., Liu, Z., Fleming, J., Haque, S. J., Robe, P., Chakravarti, A., Cui, T., Bell, E. H., McElroy, J., Becker, A., Gulati, P., Geurts, M., Mladkova, N., Gray, A., Liu, K., Yang, L., Liu, Z., Fleming, J., Haque, S. J., Robe, P., and Chakravarti, A.

Published
2018

38. miR-4516 is a Novel Prognostic Biomarker and Promotes Tumorigenesis via Targeting PTPN14-Mediated Regulation of the Hippo Pathway in Glioblastoma

Author

Cui, T., Bell, E. H., McElroy, J., Becker, A., Gulati, P., Geurts, M., Mladkova, N., Gray, A., Liu, K., Yang, L., Liu, Z., Fleming, J., Haque, S. J., Robe, P., Chakravarti, A., Cui, T., Bell, E. H., McElroy, J., Becker, A., Gulati, P., Geurts, M., Mladkova, N., Gray, A., Liu, K., Yang, L., Liu, Z., Fleming, J., Haque, S. J., Robe, P., and Chakravarti, A.

Published
2018

39. miR-4516 is a Novel Prognostic Biomarker and Promotes Tumorigenesis via Targeting PTPN14-Mediated Regulation of the Hippo Pathway in Glioblastoma

Author

Opleiding Neurologie, Brain, CMM Groep Klumperman, Neurochirurgie, Cancer, Cui, T., Bell, E. H., McElroy, J., Becker, A., Gulati, P., Geurts, M., Mladkova, N., Gray, A., Liu, K., Yang, L., Liu, Z., Fleming, J., Haque, S. J., Robe, P., Chakravarti, A., Opleiding Neurologie, Brain, CMM Groep Klumperman, Neurochirurgie, Cancer, Cui, T., Bell, E. H., McElroy, J., Becker, A., Gulati, P., Geurts, M., Mladkova, N., Gray, A., Liu, K., Yang, L., Liu, Z., Fleming, J., Haque, S. J., Robe, P., and Chakravarti, A.

Published
2018

40. MGMT Protein Expression Adds Prognostic Value Beyond MGMT Promoter Methylation and Stratifies Survival Prognoses of Un-Methylated Glioblastoma Patients

Author

Opleiding Neurologie, Brain, Neurochirurgie, Cancer, Becker, A., Bell, E. H., McElroy, J., Cui, T., Geurts, M., Liu, Z., Haque, S. J., Robe, P., Chakravarti, A., Opleiding Neurologie, Brain, Neurochirurgie, Cancer, Becker, A., Bell, E. H., McElroy, J., Cui, T., Geurts, M., Liu, Z., Haque, S. J., Robe, P., and Chakravarti, A.

Published
2018

41. Effects of valproic acid on NF-κB signaling in glioblastoma

Author

Berendsen, S., Frijlink, E., Kroonen, J., Spliet, W. G. M., Van Hecke, W., Seute, T., Snijders, T. J., Robe, P. A., Berendsen, S., Frijlink, E., Kroonen, J., Spliet, W. G. M., Van Hecke, W., Seute, T., Snijders, T. J., and Robe, P. A.

Published
2016

45. STABILITY OF ACTIONABLE MUTATIONS IN PRIMARY AND RECURRENT GLIOBLASTOMAS

Author

Draaisma, K., Taphoorn, M., Weyerbrock, A., Sanson, M., Gorlia, T., Golfinopoulos, V., Kros, J. M., Robe, P. A., van den Bent, M. M. J., French, J., Draaisma, K., Taphoorn, M., Weyerbrock, A., Sanson, M., Gorlia, T., Golfinopoulos, V., Kros, J. M., Robe, P. A., van den Bent, M. M. J., and French, J.

Published
2016

47. STABILITY OF ACTIONABLE MUTATIONS IN PRIMARY AND RECURRENT GLIOBLASTOMAS

Author

Draaisma, K., Taphoorn, M., Weyerbrock, A., Sanson, M., Gorlia, T., Golfinopoulos, V., Kros, J. M., Robe, P. A., van den Bent, M. M. J., French, J., Draaisma, K., Taphoorn, M., Weyerbrock, A., Sanson, M., Gorlia, T., Golfinopoulos, V., Kros, J. M., Robe, P. A., van den Bent, M. M. J., and French, J.

Published
2016

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