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Retinopathy of prematurity (ROP) is one of the leading causes of childhood visual impairment and blindness. However, there are still very few effective pharmacological interventions for ROP. Histone deacetylase 6 (HDAC6)-mediated disassembly of photoreceptor cilia has recently been implicated as an early event in the pathogenesis of ROP. Herein it is shown that enhanced expression of HDAC6 by intravitreal injection of adenoviruses encoding HDAC6 induces the typical pathological changes associated with ROP in mice, including disruption of the membranous disks of photoreceptor outer segments and a decrease in electroretinographic amplitudes. Hdac6 transgenic mice exhibit similar ROP-related defects in retinal structures and functions and disassembly of photoreceptor cilia, whereas Hdac6 knockout mice are resistant to oxygen change-induced retinal defects. It is further shown that blocking HDAC6-mediated cilium disassembly by intravitreal injection of small-molecule compounds protect mice from ROP-associated retinal defects. The findings indicate that pharmacological targeting of the HDAC6-cilium axis may represent a promising strategy for the prevention of ROP.

Conventional super-resolution (SR) schemes make heavy use of convolutional neural networks (CNNs), which involve intensive multiply-accumulate (MAC) operations, and require specialized hardware such as graphics processing units. This contradicts the regime of edge AI that often runs on devices strained by power, computing, and storage resources. Such a challenge has motivated a series of lookup table (LUT)-based SR schemes that employ simple LUT readout and largely elude CNN computation. Nonetheless, the multi-megabyte LUTs in existing methods still prohibit on-chip storage and necessitate off-chip memory transport. This work tackles this storage hurdle and innovates hundred-kilobyte LUT (HKLUT) models amenable to on-chip cache. Utilizing an asymmetric two-branch multistage network coupled with a suite of specialized kernel patterns, HKLUT demonstrates an uncompromising performance and superior hardware efficiency over existing LUT schemes. Our implementation is publicly available at: https://github.com/jasonli0707/hklut.

Most deep neural networks (DNNs) consist fundamentally of convolutional and/or fully connected layers, wherein the linear transform can be cast as the product between a filter matrix and a data matrix obtained by arranging feature tensors into columns. The lately proposed deformable butterfly (DeBut) decomposes the filter matrix into generalized, butterflylike factors, thus achieving network compression orthogonal to the traditional ways of pruning or low-rank decomposition. This work reveals an intimate link between DeBut and a systematic hierarchy of depthwise and pointwise convolutions, which explains the empirically good performance of DeBut layers. By developing an automated DeBut chain generator, we show for the first time the viability of homogenizing a DNN into all DeBut layers, thus achieving an extreme sparsity and compression. Various examples and hardware benchmarks verify the advantages of All-DeBut networks. In particular, we show it is possible to compress a PointNet to < 5% parameters with < 5% accuracy drop, a record not achievable by other compression schemes., Comment: 7 pages, 3 figures, accepted as a brief paper in IEEE Transactions on Neural Networks and Learning Systems (TNNLS)

A novel deep neural network (DNN) architecture is proposed wherein the filtering and linear transform are realized solely with product quantization (PQ). This results in a natural implementation via content addressable memory (CAM), which transcends regular DNN layer operations and requires only simple table lookup. Two schemes are developed for the end-to-end PQ prototype training, namely, through angle- and distance-based similarities, which differ in their multiplicative and additive natures with different complexity-accuracy tradeoffs. Even more, the distance-based scheme constitutes a truly multiplier-free DNN solution. Experiments confirm the feasibility of such Product-Quantized Content Addressable Memory Network (PECAN), which has strong implication on hardware-efficient deployments especially for in-memory computing.

We introduce a new kind of linear transform named Deformable Butterfly (DeBut) that generalizes the conventional butterfly matrices and can be adapted to various input-output dimensions. It inherits the fine-to-coarse-grained learnable hierarchy of traditional butterflies and when deployed to neural networks, the prominent structures and sparsity in a DeBut layer constitutes a new way for network compression. We apply DeBut as a drop-in replacement of standard fully connected and convolutional layers, and demonstrate its superiority in homogenizing a neural network and rendering it favorable properties such as light weight and low inference complexity, without compromising accuracy. The natural complexity-accuracy tradeoff arising from the myriad deformations of a DeBut layer also opens up new rooms for analytical and practical research. The codes and Appendix are publicly available at: https://github.com/ruilin0212/DeBut.

Recent results have revealed an interesting observation in a trained convolutional neural network (CNN), namely, the rank of a feature map channel matrix remains surprisingly constant despite the input images. This has led to an effective rank-based channel pruning algorithm, yet the constant rank phenomenon remains mysterious and unexplained. This work aims at demystifying and interpreting such rank behavior from a frequency-domain perspective, which as a bonus suggests an extremely efficient Fast Fourier Transform (FFT)-based metric for measuring channel importance without explicitly computing its rank. We achieve remarkable CNN channel pruning based on this analytically sound and computationally efficient metric and adopt it for repetitive pruning to demonstrate robustness via our scheme named Energy-Zoned Channels for Robust Output Pruning (EZCrop), which shows consistently better results than other state-of-the-art channel pruning methods.

Elasticities in depth, width, kernel size and resolution have been explored in compressing deep neural networks (DNNs). Recognizing that the kernels in a convolutional neural network (CNN) are 4-way tensors, we further exploit a new elasticity dimension along the input-output channels. Specifically, a novel nuclear-norm rank minimization factorization (NRMF) approach is proposed to dynamically and globally search for the reduced tensor ranks during training. Correlation between tensor ranks across multiple layers is revealed, and a graceful tradeoff between model size and accuracy is obtained. Experiments then show the superiority of NRMF over the previous non-elastic variational Bayesian matrix factorization (VBMF) scheme., Comment: 8 pages, 5 figures