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BACKGROUND: Rapid and accurate markers to aid diagnosis of sepsis are needed in neonatal foals. The CBC variable red blood cell distribution width (RDW) to platelet ratio (RPR) is associated with inflammatory response and linked to poor outcomes of sepsis in human patients. HYPOTHESIS: Explore the correlation of RPR with sepsis in neonatal foals and evaluate RPR predictive and prognostic value. ANIMALS: Three hundred seventeen hospitalized neonatal foals ≤7 days of age that had a CBC and physical exam performed at admission between 2012 and 2021. METHODS: Retrospective case-control study. Clinical records were used to calculate sepsis scores and define groups. Red blood cell distribution width to platelet ratio was calculated and compared between groups (septic vs nonseptic) based on Kruskal-Wallis and Wilcoxon signed-rank tests. A multivariate logistic regression model to predict sepsis was created. The cutoff for RPR was obtained based on the maximal Youden Index. The Kaplan-Meier method and the log-rank test were used to estimate survival curves and compare survival rates based on RPR. RESULTS: Red blood cell distribution width to platelet ratio was significantly higher in septic foals (Median = 0.099, confidence interval [CI] [0.093; 0.108]) than in sick nonseptic (0.085, CI [0.083; 0.089]) and healthy foals (0.081, CI [0.077; 0.086]; P < .0001). Red blood cell distribution width to platelet ratio was able to predict sepsis with high accuracy (AUC = 82.1%). The optimal RPR cutoff for sepsis was 0.09. CONCLUSIONS AND CLINICAL IMPORTANCE: Red blood cell distribution width to platelet ratio calculation is practical, inexpensive, and based on CBC-derived data. Calculation of RPR along with CBC can aid in the diagnosis of sepsis and estimation of outcome.

Introduction: Prevalence of anemia in pregnant women is most common in India and the prevalence averages 56%. Iron Deficiency Anemia has been claimed to be predominant cause of anemia in pregnant women. This study was intended to study iron deficiency anemia in pregnant women whose hemoglobin level is less than 10gm%. Methods: 100 cases of pregnant women with hemoglobin less than 10gm% were included. All the hematological parameters including RDW were obtained through analyzer. Peripheral smear stained with field stain was evaluated for morphology. Serum ferritin was done for confirmation of Iron deficiency anemia. Results: Out of 100casesofsuspectedanemia, 65 cases (65%) were diagnosed as iron deficient. Most of the cases were in the age group of 18-25 years. Conclusion: In conclusion, with increasing severity, MCV and serum ferritin decreases and it is sensitive enough to diagnose Iron Deficiency Anemia. We have found that there is statistically significant association between RDW and Serum Ferritin in diagnosing Iron Deficiency Anemia.

Introduction: Prevalence of anemia in pregnant women is most common in India and the prevalence averages 56%. Iron Deficiency Anemia has been claimed to be predominant cause of anemia in pregnant women. This study was intended to study iron deficiency anemia in pregnant women whose hemoglobin level is less than 10gm%. Methods: 100 cases of pregnant women with hemoglobin less than 10gm% were included. All the hematological parameters including RDW were obtained through analyzer. Peripheral smear stained with field stain was evaluated for morphology. Serum ferritin was done for confirmation of Iron deficiency anemia. Results: Out of 100casesofsuspectedanemia, 65 cases (65%) were diagnosed as iron deficient. Most of the cases were in the age group of 18-25 years. Conclusion: In conclusion, with increasing severity, MCV and serum ferritin decreases and it is sensitive enough to diagnose Iron Deficiency Anemia. We have found that there is statistically significant association between RDW and Serum Ferritin in diagnosing Iron Deficiency Anemia.

Latar Belakang: Stroke iskemik menyebabkan terjadinya inflamasi sel. Sitokin inflamasi menyebabkan peningkatan Red-Blood-Cell Distribution Width (RDW) dan mencegah maturasi sel darah merah. Pemeriksaan RDW rutin dan murah dikerjakan, sehingga diharapkan dapat digunakan sebagai prediksi keparahan klinis pada pasien stroke. Tujuan: Untuk mengetahui hubungan RDW terhadap skor National Institutes of Health Stroke Scale (NIHSS) pasien stroke iskemik akut di Unit Stroke Rumah Sakit Umum Pusat (RSUP) Dr. Sardjito Yogyakarta. Metode Penelitian: Studi dengan rancangan potong lintang. Subjek penelitian adalah pasien stroke iskemik yang dirawat di Unit Stroke RSUP Dr. Sardjito periode Januari 2014 hingga Desember 2015. Diagnosis stroke iskemik akut ditegakkan berdasarkan anamnesis, pemeriksaan fisik, dan pemeriksaan Computed Tomography (CT)-scan kepala. Data NIHSS dan RDW diambil saat admisi dan diuji korelasi dengan tes Pearson. Nilai p<0,05 dianggap signifikan secara statistik. Hasil: Sebanyak 51 orang subjek dimasukkan dalam penelitian. Hasil analisis menunjukkan bahwa RDW serum berkorelasi terhadap NIHSS (r= 0,296; p=0,035).Simpulan: Terdapat korelasi positif antara kadar RDW dengan nilai NIHSS pada penderita stroke iskemik akut dengan kekuatan korelasi rendah, sehingga semakin tinggi kadar RDW, maka semakin tinggi nilai NIHSS. Kata Kunci: RDW, Stroke Iskemik Akut, Keparahan, NIHSS

Latar Belakang: Stroke iskemik menyebabkan terjadinya inflamasi sel. Sitokin inflamasi menyebabkan peningkatan Red-Blood-Cell Distribution Width (RDW) dan mencegah maturasi sel darah merah. Pemeriksaan RDW rutin dan murah dikerjakan, sehingga diharapkan dapat digunakan sebagai prediksi keparahan klinis pada pasien stroke. Tujuan: Untuk mengetahui hubungan RDW terhadap skor National Institutes of Health Stroke Scale (NIHSS) pasien stroke iskemik akut di Unit Stroke Rumah Sakit Umum Pusat (RSUP) Dr. Sardjito Yogyakarta. Metode Penelitian: Studi dengan rancangan potong lintang. Subjek penelitian adalah pasien stroke iskemik yang dirawat di Unit Stroke RSUP Dr. Sardjito periode Januari 2014 hingga Desember 2015. Diagnosis stroke iskemik akut ditegakkan berdasarkan anamnesis, pemeriksaan fisik, dan pemeriksaan Computed Tomography (CT)-scan kepala. Data NIHSS dan RDW diambil saat admisi dan diuji korelasi dengan tes Pearson. Nilai p<0,05 dianggap signifikan secara statistik. Hasil: Sebanyak 51 orang subjek dimasukkan dalam penelitian. Hasil analisis menunjukkan bahwa RDW serum berkorelasi terhadap NIHSS (r= 0,296; p=0,035).Simpulan: Terdapat korelasi positif antara kadar RDW dengan nilai NIHSS pada penderita stroke iskemik akut dengan kekuatan korelasi rendah, sehingga semakin tinggi kadar RDW, maka semakin tinggi nilai NIHSS. Kata Kunci: RDW, Stroke Iskemik Akut, Keparahan, NIHSS

No-till (NT) has repeatedly been reported to result in several environmental advantages, including the reduction of soil erosion, sequestration of carbon from the atmosphere and increase of water retention in soils. However, experimental evidences to date show negative effects of NT on soil physical parameters (i.e., increasing penetration resistance and soil bulk density) and root development of plants, thus reducing crop yield. A three-year field study (2014–2016) was conducted to assess the effects of NT vs conventional tillage (CT) on root growth in maize, soybean, and winter wheat, on a silty clay soil in the Northern Italy. Root length density (RLD), diameter class length (DCL), root dry weight (RDW) and roots composition (C and N) in the top 60 cm of soil were measured. The total amount of root C (TRC) was calculated by multiplying RDW by root C content. Relationships among root traits, soil bulk density (BD) and penetration resistance (PR) were investigated using the non-parametric Spearman rank coefficient. RLD was significantly increased under NT compared to CT in the topsoil (0–5 cm) in maize (6.37 vs. 2.03 mg cm−3) and winter wheat (5.38 vs. 2.90 cm cm−3), while it was lower in NT than in CT in the deeper soil (5–15 cm) only in maize (3.19 vs. 4.53 cm cm−3). RDW was increased under NT compared to CT in the 0–5 cm layer in maize (3.86 vs.0.50 mg cm−3), soybean (4.33 vs. 0.43 mg cm−3), and winter wheat (0.96 vs. 0.38 mg cm−3). NT significantly reduced root C:N ratio of maize (-9%), increased C:N ratio of soybean (+14%), and did not affect C:N ratio of winter wheat. This was mainly related to the effect of NT on coarse roots, which decreased average roots N content. A negative correlation between root traits (RLD, RDW) and soil physical parameters (BD, PR) was found in this study under NT while no correlation occurred for CT. This corroborates the hypothesis that when tillage is abandoned roots are major drivers and detectors of soil physical conditions, wh

Red blood cell distribution width (RDW) is the coefficient of variation of red blood cell size, considered to be associated with cardiovascular disease (CVD). This study aimed to comprehensively synthesize previous studies on RDW and CVD outcomes through an overall and dose-response meta-analysis. PubMed, Embase and Web of Science were searched systematically for English and Chinese language publications up to November 30, 2015. We extracted data from publications matching our inclusion criteria for calculating pooled hazard ratio (HR), which was used to assess prognostic impact of RDW on CVD. Twenty-seven articles, consisting of 28 studies and 102,689 participants (mean age 63.9 years, 63,703 males/36,846 females, 2,140 gender-unmentioned subjects) were included in the present meta-analysis. The pooled HRs are 1.12 (95% CI = 1.09–1.15) for the association of all-cause mortality (ACM) per 1% increase of RDW, 1.12(95% CI = 1.08–1.17) for major adverse cardiac events (MACEs) per 1% increase of RDW. A dose-response curve relating RDW increase to its effect on CVD outcomes was established (pcurve < 0.001). For every 1-unit increase of RDW, there is an increased risk of occurrence of ACM (pooled HR = 1.03, 95% CI = 1.02–1.04) and MACEs (pooled HR = 1.04, 95% CI = 1.01–1.06). This study indicates RDW may be a prognostic indicator for CVD outcomes.

Red blood cell distribution width (RDW) is the coefficient of variation of red blood cell size, considered to be associated with cardiovascular disease (CVD). This study aimed to comprehensively synthesize previous studies on RDW and CVD outcomes through an overall and dose-response meta-analysis. PubMed, Embase and Web of Science were searched systematically for English and Chinese language publications up to November 30, 2015. We extracted data from publications matching our inclusion criteria for calculating pooled hazard ratio (HR), which was used to assess prognostic impact of RDW on CVD. Twenty-seven articles, consisting of 28 studies and 102,689 participants (mean age 63.9 years, 63,703 males/36,846 females, 2,140 gender-unmentioned subjects) were included in the present meta-analysis. The pooled HRs are 1.12 (95 % CI = 1.09–1.15) for the association of all-cause mortality (ACM) per 1 % increase of RDW, 1.12(95 % CI = 1.08–1.17) for major adverse cardiac events (MACEs) per 1% increase of RDW. A dose-response curve relating RDW increase to its effect on CVD outcomes was established (pcurve < 0.001). For every 1-unit increase of RDW, there is an increased risk of occurrence of ACM (pooled HR = 1.03, 95 % CI = 1.02–1.04) and MACEs (pooled HR = 1.04, 95 % CI = 1.01–1.06). This study indicates RDW may be a prognostic indicator for CVD outcomes.

Hou, H., Sun, T., Li, C., Li, Y., Guo, Z., Wang, W., & Li, D. (2017). An overall and dose-response meta-analysis of red blood cell distribution width and CVD outcomes. Sci. Rep. 7, 43420. Available here