Search

Background: The COVID-19 pandemic, associated with confinement and social isolation, seems to have impacted the course of many mental disorders in children and adolescents. An increase in hospital admission rates for juvenile anorexia nervosa (AN) has been documented in many regions of the world. However, data from Europe are scarce. Methods: We asked clinicians in specialized eating disorder units in hospitals of maximum care in France, Germany, Italy, Spain, Sweden, and the Netherlands to report on (i) overall (inpatient and outpatient) and (ii) inpatient admission rates for adolescents with AN during 2019 and 2020. Additionally, a modified version of the COVID Isolation Eating Scale (CIES) was used to assess the child and adolescent psychiatrists’ estimations of a possible increase in symptom severity in children and adolescents with AN during the COVID-19 pandemic and to (iii) inquire about the contributing factors perceived by the caring professionals. Results: Four out of six representatives of European hospitals described a higher rate of overall admissions during the pandemic. Three hospitals out of six reported an increase in inpatient admissions, and two centres had constant high numbers of admissions of both outpatients and inpatients. The clinicians perceived a higher symptom severity in 2020 than in 2019, especially involving more frequent use of social media, longer duration of exercising, and more restrictive eating. They supposed an increase in social media consumption, a perceived “loss of control”, and a lack of in-person assessments and weight controls as the main contributing factors for the deterioration in AN numbers and symptomatology. Conclusions: The COVID-19 pandemic seems to have had a deep impact on symptom severity in AN, which is mirrored by a large increase in admission rates across Europe. An increase in exercise, social media consumption, a perceived “loss of control”, and a lack of face-to-face health care seem to have contributed t

BACKGROUND: SARS-CoV-2 (COVID-19) elicits a T-cell antigen-mediated immune response of variable efficacy. To understand this variability, we explored transcriptomic expression of angiotensin-converting enzyme 2 (ACE2, the SARS-CoV-2 receptor) and of immunoregulatory genes in normal lung tissues from patients with non-small cell lung cancer (NSCLC). METHODS: This study used the transcriptomic and the clinical data for NSCLC patients generated during the CHEMORES study [n = 123 primary resected (early-stage) NSCLC] and the WINTHER clinical trial (n = 32 metastatic NSCLC). RESULTS: We identified patient subgroups with high and low ACE2 expression (p = 1.55 × 10-19) in normal lung tissue, presumed to be at higher and lower risk, respectively, of developing severe COVID-19 should they become infected. ACE2 transcript expression in normal lung tissues (but not in tumor tissue) of patients with NSCLC was higher in individuals with more advanced disease. High-ACE2 expressors had significantly higher levels of CD8+ cytotoxic T lymphocytes and natural killer cells but with presumably impaired function by high Thymocyte Selection-Associated High Mobility Group Box Protein TOX (TOX) expression. In addition, immune checkpoint-related molecules - PD-L1, CTLA-4, PD-1, and TIGIT - are more highly expressed in normal (but not tumor) lung tissues; these molecules might dampen immune response to either viruses or cancer. Importantly, however, high inducible T-cell co-stimulator (ICOS), which can amplify immune and cytokine reactivity, significantly correlated with high ACE2 expression in univariable analysis of normal lung (but not lung tumor tissue). CONCLUSIONS: We report a normal lung immune-tolerant state that may explain a potential comorbidity risk between two diseases - NSCLC and susceptibility to COVID-19 pneumonia. Further, a NSCLC patient subgroup has normal lung tissue expressing high ACE2 and high ICOS transcripts, the latter potentially promoting a hyperimmune response, a

Funding agency: Projekt DEAL.

Background: The COVID-19 pandemic, associated with confinement and social isolation, seems to have impacted the course of many mental disorders in children and adolescents. An increase in hospital admission rates for juvenile anorexia nervosa (AN) has been documented in many regions of the world. However, data from Europe are scarce. Methods: We asked clinicians in specialized eating disorder units in hospitals of maximum care in France, Germany, Italy, Spain, Sweden, and the Netherlands to report on (i) overall (inpatient and outpatient) and (ii) inpatient admission rates for adolescents with AN during 2019 and 2020. Additionally, a modified version of the COVID Isolation Eating Scale (CIES) was used to assess the child and adolescent psychiatrists’ estimations of a possible increase in symptom severity in children and adolescents with AN during the COVID-19 pandemic and to (iii) inquire about the contributing factors perceived by the caring professionals. Results: Four out of six representatives of European hospitals described a higher rate of overall admissions during the pandemic. Three hospitals out of six reported an increase in inpatient admissions, and two centres had constant high numbers of admissions of both outpatients and inpatients. The clinicians perceived a higher symptom severity in 2020 than in 2019, especially involving more frequent use of social media, longer duration of exercising, and more restrictive eating. They supposed an increase in social media consumption, a perceived “loss of control”, and a lack of in-person assessments and weight controls as the main contributing factors for the deterioration in AN numbers and symptomatology. Conclusions: The COVID-19 pandemic seems to have had a deep impact on symptom severity in AN, which is mirrored by a large increase in admission rates across Europe. An increase in exercise, social media consumption, a perceived “loss of control”, and a lack of face-to-face health care seem to have contributed t

This paper describes a novel method for constructing complex concrete structures from small-scale individualized elements. The method was developed through the investigation of laser cutting, folding and concrete casting in PETG plastic sheets and funicular grid shell simulations as a generator of complex geometry. In two full-scale experiments, grid shell structures have been designed and built at Aarhus School of Architecture and the University of Technology, Sydney, in 2011 and 2012. The novel design method is described as an iterative process, negotiating both physical and digital constraints. This involves consideration of the relations between geometry and technique, as well as the use of form-finding and simulation algorithms for shaping and optimising the shape of the structure. Custom-made scripts embedded in 3D-modeling tools were used for producing the information necessary for realising the construction comprised of discrete concrete elements.

This paper describes a novel method for constructing complex concrete structures from small-scale individualized elements. The method was developed through the investigation of laser cutting, folding and concrete casting in PETG plastic sheets and funicular grid shell simulations as a generator of complex geometry. In two full-scale experiments, grid shell structures have been designed and built at Aarhus School of Architecture and the University of Technology, Sydney, in 2011 and 2012. The novel design method is described as an iterative process, negotiating both physical and digital constraints. This involves consideration of the relations between geometry and technique, as well as the use of form-finding and simulation algorithms for shaping and optimising the shape of the structure. Custom-made scripts embedded in 3D-modeling tools were used for producing the information necessary for realising the construction comprised of discrete concrete elements.

p. 966-876, The new geometrical developments open new perspectives for free-form design, making it possible to escape from planar triangular or quadrilateral discretizations. Recent advances in theory algorithms allow for the discretization of any surface using only single curvature panels thus allowing the realisation of smooth double curvature glazed envelops of any form. Grid shell structures usually present a nearly in plane uniform behaviour, but previous realisations have shown that grid shells can be designed also according to an anisotropic inplane arrangement. The control of principal direction and the fine tuning of the stiffness of the different structural elements (arcs, cables etc.) is a tool for adjusting the form-finding thus controlling the resulting geometry. Moreover, the form-finding can also be performed without researching a constant stress (self weight); in this case an even wider range of forms become possible. These new geometrical and structural approaches have been coupled together and tested in re-designing, as a case study, the glazed roof of the Neumunster Abbey in Luxembourg. Such approach allowed for the conception of an efficient structure supporting a smooth double curvature glass skin, made out of only single curvature panels, perfectly coherent with the perimeter of the courtyard i.e. matching all the edges without any gaps.

p. 966-876, The new geometrical developments open new perspectives for free-form design, making it possible to escape from planar triangular or quadrilateral discretizations. Recent advances in theory algorithms allow for the discretization of any surface using only single curvature panels thus allowing the realisation of smooth double curvature glazed envelops of any form. Grid shell structures usually present a nearly in plane uniform behaviour, but previous realisations have shown that grid shells can be designed also according to an anisotropic inplane arrangement. The control of principal direction and the fine tuning of the stiffness of the different structural elements (arcs, cables etc.) is a tool for adjusting the form-finding thus controlling the resulting geometry. Moreover, the form-finding can also be performed without researching a constant stress (self weight); in this case an even wider range of forms become possible. These new geometrical and structural approaches have been coupled together and tested in re-designing, as a case study, the glazed roof of the Neumunster Abbey in Luxembourg. Such approach allowed for the conception of an efficient structure supporting a smooth double curvature glass skin, made out of only single curvature panels, perfectly coherent with the perimeter of the courtyard i.e. matching all the edges without any gaps.

p. 966-876, The new geometrical developments open new perspectives for free-form design, making it possible to escape from planar triangular or quadrilateral discretizations. Recent advances in theory algorithms allow for the discretization of any surface using only single curvature panels thus allowing the realisation of smooth double curvature glazed envelops of any form. Grid shell structures usually present a nearly in plane uniform behaviour, but previous realisations have shown that grid shells can be designed also according to an anisotropic inplane arrangement. The control of principal direction and the fine tuning of the stiffness of the different structural elements (arcs, cables etc.) is a tool for adjusting the form-finding thus controlling the resulting geometry. Moreover, the form-finding can also be performed without researching a constant stress (self weight); in this case an even wider range of forms become possible. These new geometrical and structural approaches have been coupled together and tested in re-designing, as a case study, the glazed roof of the Neumunster Abbey in Luxembourg. Such approach allowed for the conception of an efficient structure supporting a smooth double curvature glass skin, made out of only single curvature panels, perfectly coherent with the perimeter of the courtyard i.e. matching all the edges without any gaps.

In Magnetic Resonance Imaging (MRI), to achieve sufficient Signal to Noise Ratio (SNR), the electrical performance of the RF coil is critical. We developed a device (microcoil) based on the original concept of monolithic resonator. This paper presents the used fabrication process based on micromoulding. The dielectric substrates are flexible thin films of polymer, which allow the microcoil to be form fitted to none-plane surface. Electrical characterizations of the RF coils are first performed and results are compared to the attempted values. Proton MRI of a saline phantom using a flexible RF coil of 15 mm in diameter is performed. When the coil is conformed to the phantom surface, a SNR gain up to 2 is achieved as compared to identical but planar RF coil. Finally, the flexible coil is used in vivo to perform MRI with high spatial resolution on a mouse using a small animal dedicated scanner operating at in a 2.35 T., Comment: Submitted on behalf of TIMA Editions (http://irevues.inist.fr/tima-editions)

Cardiovascular and energetic responses at rest, during 30 min of exercise (mechanical output: 125 watts) and for a subsequent recovery period of 5 min were compared in two groups, each comprising 21 residents at an altitude of 2.850 m. One group was in the asymptomatic phase of Chagas' disease with positive serological tests for T. cruzi, whereas the other was without Chagas' disease (negative serological tests). The two groups were similar as regards age, weight-for-height, blood parameters, nutritional status and heart and lung functions, including heart rate and frontal plane QRS axis determinations. At rest, they differed in that maximal and minimal arterial blood pressures were slightly but significantly lower in the group with Chagas' positive serological tests than in the controls. During exercise and recovery, the only differences between them and the controls were that their minimal diastolic arterial blood pressure was significantly lower. In absolute values, the rises in arterial pressure due to exercise were exactly the same in the two groups. Maximal O2 uptake was identical in both groups, as was exercise steady state VO2. These findings indicate that the asymptomatic subjects with Chagas' disease had a normal work capacity and were not affected by high altitude., Journal Article, Research Support, Non-U.S. Gov't, info:eu-repo/semantics/published

Journal Article, Research Support, Non-U.S. Gov't, info:eu-repo/semantics/published

Cardiovascular and energetic responses at rest, during 30 min of exercise (mechanical output: 125 watts) and for a subsequent recovery period of 5 min were compared in two groups, each comprising 21 residents at an altitude of 2.850 m. One group was in the asymptomatic phase of Chagas' disease with positive serological tests for T. cruzi, whereas the other was without Chagas' disease (negative serological tests). The two groups were similar as regards age, weight-for-height, blood parameters, nutritional status and heart and lung functions, including heart rate and frontal plane QRS axis determinations. At rest, they differed in that maximal and minimal arterial blood pressures were slightly but significantly lower in the group with Chagas' positive serological tests than in the controls. During exercise and recovery, the only differences between them and the controls were that their minimal diastolic arterial blood pressure was significantly lower. In absolute values, the rises in arterial pressure due to exercise were exactly the same in the two groups. Maximal O2 uptake was identical in both groups, as was exercise steady state VO2. These findings indicate that the asymptomatic subjects with Chagas' disease had a normal work capacity and were not affected by high altitude., Journal Article, Research Support, Non-U.S. Gov't, info:eu-repo/semantics/published

Journal Article, Research Support, Non-U.S. Gov't, info:eu-repo/semantics/published

Contient une table des matières, Avec mode texte

Contient une table des matières, Avec mode texte