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Objective: A long-term decline in health-related quality of life (HRQoL) has been reported after coronavirus disease 2019 (COVID-19). Studies with people with persistent symptoms showed inconsistent outcomes. Cognition and emotion are important determinants in HRQoL, but few studies have examined their prognostic significance for HRQoL and functionality in post-COVID patients with persisting symptoms. We aimed to describe QoL, HRQoL, and functioning in individuals post-COVID with varying COVID-19 severities and to investigate the predictive value of cognitive and emotional variables for QoL, HRQoL, and functioning. Methods: In total, 492 participants (398 post-COVID and 124 healthy controls) underwent a neurobehavioral examination that included assessments of cognition, mood, QoL/HRQoL (WHOQOL-BREF, EQ-5D), and functioning (WHODAS-II). Analysis of covariance and linear regression models were used to study intergroup differences and the relationship between cognitive and emotional variables and QoL and functioning. Results: The Physical and Psychological dimensions of WHOQoL, EQ-5D, and WHODAS Cognition, Mobility, Life Activities, and Participation dimensions were significantly lower in post-COVID groups compared with a control group. Regression models explaining 23.9%–53.9% of variance were obtained for the WHOQoL-BREF dimensions and EQ-5D, with depressive symptoms, post-COVID symptoms, employment status, income, and mental speed processing as main predictors. For the WHODAS, models explaining 17%–60.2% of the variance were obtained. Fatigue, depressive symptoms, mental speed processing, and post-COVID symptoms were the main predictors. Interpretation: QoL/HRQoL and functioning after COVID-19 in individuals with persistent symptoms were lower than in non-affected persons. Depressive symptoms, fatigue, and slower mental processing speed were predictors of lower QoL/HRQoL and functioning., This research was supported by the Agency for Management of University and Research Grants (AGAUR) from the Generalitat de Catalunya (Pandemies, 202PANDE00053) and La Marató de TV3 Foundation (202111-30-31-32)., Peer Reviewed, Membres del NAUTILUS-Project Collaborative Group: Jose A. Bernia, Servei d’Anestesia Reanimacio i Clinica del Dolor, Consorci Sanitari de Terrassa (CST) (Terrassa,Barcelona, Spain); Vanesa Arauzo, Servei de Medicina Intensiva, Consorci Sanitari de Terrassa (CST) (Terrassa, Barcelona, Spain); Marta Balague-Marmaña, Hospital Sant Joan Despı Moises Broggi, Consorci Sanitari Integral (Sant Joan Despı, Spain); Cristian Perez-Pellejero, Hospital Sant Joan Despı Moises Broggi, Consorci Sanitari Integral (Sant Joan Despı, Barcelona, Spain); Silvia Cañizares, Hospital Clinic de Barcelona (Barcelona, Spain); Jose Antonio Lopez Muñoz, Occupational Health CareService, Hospital Clınic (Barcelona, Spain); Jesus Caballero, Hospital Universitari Arnau de Vilanova (Lleida, Spain); Anna Carnes-Vendrell, Hospital Universitari de Santa Maria (Lleida, Spain); Gerard Piñol-Ripoll, Hospital Universitari de Santa Maria (Lleida, Spain); Ester Gonzalez-Aguado, Consorci Sanitari Alt Penedes-Garraf (Vilafranca de Penedes, Barcelona, Spain); Carme Tayo-Juli, Consorci Sanitari Alt Penedes-Garraf (Vilafranca de Penedes, Barcelona, Spain); Eva Forcadell-Ferreres, Hospital Verge de la Cinta,(Tortosa, Tarragona, Spain); Silvia Reverte-Vilarroya, Hospital Verge de la Cinta, (Tortosa, Tarragona, Spain); Susanna Forne, Fundacio Sant Hospital de la Seu d’Urgell (La Seu d’Urgell, Lleida, Spain); Jordina Muñoz-Padros, Consorci Hospitalari de Vic (Vic, Barcelona, Spain); Anna Bartes-Plan, Consorci Hospitalari de Vic (Vic,Barcelona, Spain); Jose A. Muñoz-Moreno, Servei de Malalties Infeccioses, Fundacio Lluita contra les Infeccions - Hospital Universitari Germans Trias i Pujol (Badalona, Barcelona, Spain); Anna Prats-Paris, Servei de Malalties Infeccioses, Fundacio Lluita contra les Infeccions - Hospital Universitari Germans Trias i Pujol (Badalona, Barcelona, Spain); Anna Gasa-Roque, Hospital Universitari de Bellvitge (L’Hospitalet de Llobregat, Barcelona, Spain); Laura Casas Valls, Hospital Universitari d, Postprint (published version)

The study aimed to assess sleep quality in PCC patients and its predictors by analysing its relationship with emotional, cognitive and functional variables, as well as possible differences based on COVID-19 severity. We included 368 individuals with PCC and 123 healthy controls (HCs) from the NAUTILUS Project (NCT05307549 and NCT05307575). We assessed sleep quality (Pittsburgh Sleep Quality Index, PSQI), anxiety (Generalized Anxiety Disorder, GAD-7), depression (Patient Health Questionnaire, PHQ-9), global cognition (Montreal Cognitive Assessment, MoCA), everyday memory failures (Memory Failures of Everyday Questionnaire, MFE-30), fatigue (Chadler Fatigue Questionnaire, CFQ), quality of life (European Quality of Life-5 Dimensions, EQ-5D), and physical activity levels (International Physical Activity Questionnaire, IPAQ). 203 were nonhospitalized, 83 were hospitalized and 82 were admitted to the intensive care unit (ICU). We found statistically significant differences in the PSQI total score between the PCC and HC groups (p < 0.0001), but there were no differences among the PCC groups. In the multiple linear regressions, the PHQ-9 score was a predictor of poor sleep quality for mild PCC patients (p = 0.003); GAD-7 (p = 0.032) and EQ-5D (p = 0.011) scores were predictors of poor sleep quality in the hospitalized PCC group; and GAD-7 (p = 0.045) and IPAQ (p = 0.005) scores were predictors of poor sleep quality in the group of ICU-PCC. These results indicate that worse sleep quality is related to higher levels of depression and anxiety, worse quality of life and less physical activity. Therapeutic strategies should focus on these factors to have a positive impact on the quality of sleep., This research was supported by: Grants from the Agency for Management of University and Research Grants (AGAUR) from the Generalitat de Catalunya (Pandemies, 202PANDE00053) and La Marató de TV3 Foundation (202111-30-31-32) to MG.- Grants from the Instituto de Salud Carlos III de Madrid (PI22/01687, ISCIII) and Agency for Management of University and Research Grants (2021SGR 00761) to GPR., Peer Reviewed, Membres del NAUTILUS-Project Collaborative Group: Vanesa Arauzo j, Jose A. Bernia j, Marta Balague-Marmaña k, Berta Valles-Pauls k, Ester Gonzalez-Aguado l, Carme Tayó-Juli l, Eva Forcadell-Ferreres m, Silvia Reverte-Vilarroya m, Susanna Forné n, Anna Bartes-Plans o, Jordina Muñoz-Padros o, Jose A. Muñoz-Moreno p, Anna Prats-Paris p, Inmaculada Rico q, Nuria Sabé q, Marta Almeria r, Laura Casas r, Maria José Ciudad s, Anna Ferré s, Tamar Garzon t, Marta Cullell u, Sonia Vega u, Sílvia Alsina v, Maria J. Maldonado-Belmonte w, Susana Vazquez-Rivera w, Eva Baillès x, Sandra Navarro x / j Consorci Sanitari de Terrassa (CST), Terrassa, Spain; k Hospital Sant Joan Despí Moisès Broggi, Consorci Sanitari Integral Jesús Caballero, Hospital Universitari Arnau de Vilanova, Lleida, Spain; l Consorci Sanitari Alt Penedès-Garraf, Vilafranca de Penedés, Barcelona, Spain; m Hospital Verge de la Cinta, Tortosa, Tarragona, Spain; n Fundació Sant Hospital de la Seu d’Urgell, La Seu d’Urgell, Lleida, Spain; o Consorci Hospitalari de Vic, Vic, Barcelona, Spain; p Servei de Malalties Infeccioses, Fundació Lluita contra les Infeccions – Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain; q Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain; r Hospital Universitari Mútua Terrassa, Terrassa, Barcelona, Spain; s Badalona Serveis Assistencials, Badalona, Barcelona, Spain; t Manuela Lozano, Institut d’Assistència Sanitària, Girona, Spain; u Fundació Salut Empordà, Figueres, Girona, Spain; v Fundació Hospital de Puigcerdà, Puigcerdà, Girona, Spain; w Hospital Universitario Central de la Cruz Roja San José y Santa Adela, Madrid, Spain; x Servei Andorrà d’Atenció Sanitària (SAAS), Andorra, Postprint (published version)

Són molts els estudis que avalen l'enfocament educatiu AICLE i els seus efectes beneficiosos sobre l'aprenentatge de les llengües estrangeres. No obstant, nombrosos experts apunten que només l'aplicació de programes ben estructurats i a llarg termini poden ajudar a obtenir bons resultats. Amb aquest treball es pretén analitzar els avantatges i inconvenients que tenen els centres educatius per aplicar l'enfocament AICLE a les programacions dels cicles formatius de la família professional de Química. Per aconseguir-ho, s'ha elaborat una enquesta dirigida al professorat de cicles formatius de Química per tal d'analitzar com s'està introduint la llengua anglesa i recollir noves propostes de millora en l'aplicació de l'enfocament AICLE a la Formació Professional. En paral·lel, s'ha elaborat material didàctic específic per al Mòdul Professional 3 de Proves Fisicoquímiques del Cicle Formatiu de Grau Mitjà d'Operacions de Laboratori i s'han inclòs activitats d'ensenyament-aprenentatge que tenen en compte la competència digital. Els resultats de l'enquesta han demostrat que gran part del professorat enquestat té un coneixement alt de la llengua anglesa però manifesten que és difícil impartir docència en anglès quan l'alumnat no té una bona base d'aquesta llengua. Han aportat propostes de millora com l'elaboració de recursos didàctics en anglès, proporcionar al professorat formació contínua en llengua anglesa i han recalcat que l'enfocament AICLE s'ha d'incorporar des de la primària.

Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature, Patients with post-coronavirus disease 2019 (COVID-19) conditions typically experience cognitive problems. Some studies have linked COVID-19 severity with long-term cognitive damage, while others did not observe such associations. This discrepancy can be attributed to methodological and sample variations. We aimed to clarify the relationship between COVID-19 severity and long-term cognitive outcomes and determine whether the initial symptomatology can predict long-term cognitive problems. Cognitive evaluations were performed on 109 healthy controls and 319 post-COVID individuals categorized into three groups according to the WHO clinical progression scale: severe-critical (n¿=¿77), moderate-hospitalized (n¿=¿73), and outpatients (n¿=¿169). Principal component analysis was used to identify factors associated with symptoms in the acute-phase and cognitive domains. Analyses of variance and regression linear models were used to study intergroup differences and the relationship between initial symptomatology and long-term cognitive problems. The severe-critical group performed significantly worse than the control group in general cognition (Montreal Cognitive Assessment), executive function (Digit symbol, Trail Making Test B, phonetic fluency), and social cognition (Reading the Mind in the Eyes test). Five components of symptoms emerged from the principal component analysis: the “Neurologic/Pain/Dermatologic” “Digestive/Headache”, “Respiratory/Fever/Fatigue/Psychiatric” and “Smell/ Taste” components were predictors of Montreal Cognitive Assessment scores; the “Neurologic/Pain/Dermatologic” component predicted attention and working memory; the “Neurologic/Pain/Dermatologic” and “Respiratory/Fever/Fatigue/Psychiatric” components predicted verbal memory, and the “Respiratory/Fever/Fatigue/Psychiatric,” “Neurologic/Pain/Dermatologic,” and “Digestive/Headache” components predicted executive function. Patients with severe COVID-19 exhibited persistent deficits in executive fun, This research was supported by the Agency for Management of University and Research Grants (AGAUR) from the Generalitat de Catalunya (Pandemies, 202PANDE00053) and La Marató de TV3 Foundation (202111-30-31-32)., Peer Reviewed, Article signat per 16 autors/es: Mar Ariza, Neus Cano, Bàrbara Segura, Ana Adan, Núria Bargalló, Xavier Caldú, Anna Campabadal, Maria Angeles Jurado, Maria Mataró, Roser Pueyo, Roser Sala‑Llonch, Cristian Barrué, Javier Bejar, Claudio Ulises Cortés on behalf of NAUTILUS Project Collaborative Group, Maite Garolera Carme Junqué, Postprint (published version)

One of the most prevalent symptoms of post-COVID condition is cognitive impairment, which results in a significant degree of disability and low quality of life. In studies with large sample sizes, attention, memory, and executive function were reported as long-term cognitive symptoms. This study aims to describe cognitive dysfunction in large post-COVID condition individuals, compare objective neuropsychological performance in those post-COVID condition individuals with and without cognitive complaints, and identify short cognitive exams that can differentiate individuals with post-COVID symptoms from controls. To address these aims, the Nautilus project was started in June 2021. During the first year, we collected 428 participants’ data, including 319 post-COVID and 109 healthy controls (18–65 years old) from those who underwent a comprehensive neuropsychological battery for cognitive assessment. Scores on tests assessing global cognition, learning and long-term memory, processing speed, language and executive functions were significantly worse in the post-COVID condition group than in healthy controls. Montreal Cognitive Assessment, digit symbol test, and phonetic verbal fluency were significant in the binomial logistic regression model and could effectively distinguish patients from controls with good overall sensitivity and accuracy. Neuropsychological test results did not differ between those with and without cognitive complaints. Our research suggests that patients with post-COVID conditions experience significant cognitive impairment and that routine tests like the Montreal Cognitive Assessment, digit symbol, and phonetic verbal fluency test might identify cognitive impairment. Thus, the administration of these tests would be helpful for all patients with post-COVID-19 symptoms, regardless of whether cognitive complaints are present or absent., Peer Reviewed, NAUTILUS-Project Collaborative Group, Postprint (published version)

Introduction: A significant proportion of patients with cancer who recover from Coronavirus Disease 2019 (COVID-19) may experience COVID-19 sequelae in the early post-infection phase, which negatively affect their continuity of care and oncological outcome. The long-term prevalence and clinical impact of the post-COVID-19 syndrome in patients with cancer are largely unknown. Methods: In this study, we describe the time course of COVID-19 sequelae in patients with non-advanced cancers enrolled in the OnCovid registry. Results: Overall, 186 patients were included, with a median observation period of 9.9 months (95%CI:8,8–11.3) post-COVID-19 resolution. After a median interval of 2.3 months post-COVID-19 (interquartile range: 1.4–3.7), 31 patients (16.6%) reported ≥1 sequelae, including respiratory complications (14, 7.6%), fatigue (13, 7.1%), neuro-cognitive sequelae (7, 3.8%). The vast majority of the patients were not vaccinated prior to COVID-19. COVID-19-related sequelae persisted in 9.8% and 8% of patients 6 and 12 months after COVID-19 resolution. Persistence of sequelae at first oncological follow-up was associated with history of complicated COVID-19 (45.2% vs 24.8%, p = 0.0223), irrespective of oncological features at COVID-19 diagnosis. Conclusion: This study confirms for the first time that, in a largely unvaccinated population, post-COVID-19 syndrome can affect a significant proportion of patients with non-advanced cancer who recovered from the acute illness. COVID-19 sequelae may persist up to 12 months in some patients, highlighting the need for dedicated prevention and supportive strategies.

Since its inception, social work has promoted the defense of human rights and social justice. Doing so has also implied having an influence in the political arena. Although, in some contexts, participation in the political arena of social workers is limited. Based on an analysis of the figure of Jane Addams, using a bibliographic analysis, this study shows the role that social work can play in changing policies and the importance of being coherent with personal values, as well as engaging in equal dialogue using human rights and social justice as a starting point. Jane Addams became a political entrepreneur in fields such as the struggle for women's rights, the rights of immigrants, the fight against child labor exploitation and the quest for peace. This positioning had negative repercussions on her public image, although she was finally awarded the Nobel Peace Prize., Desde sus inicios, el trabajo social ha promovido la defensa de los derechos humanos y la justicia social. Hacerlo ha implicado también tener una influencia en el ámbito político. Aunque, en algunos contextos, la participación en la arena política de los y las trabajadoras sociales es limitada. A partir del análisis de la figura de Jane Addams, mediante un análisis bibliográfico, este estudio muestra el papel que puede desempeñar el trabajo social en el cambio de políticas y la importancia de ser coherente con los valores personales, así como de entablar un diálogo igualitario tomando como punto de partida los derechos humanos y la justicia social. Jane Addams se convirtió en una emprendedora política en campos como la lucha por los derechos de la mujer, los derechos de los inmigrantes, la lucha contra la explotación laboral infantil y la búsqueda de la paz. Este posicionamiento repercutió negativamente en su imagen pública, aunque finalmente fue galardonada con el Premio Nobel de la Paz.

Since its inception, social work has promoted the defense of human rights and social justice. Doing so has also implied having an influence in the political arena. Although, in some contexts, participation in the political arena of social workers is limited. Based on an analysis of the figure of Jane Addams, using a bibliographic analysis, this study shows the role that social work can play in changing policies and the importance of being coherent with personal values, as well as engaging in equal dialogue using human rights and social justice as a starting point. Jane Addams became a political entrepreneur in fields such as the struggle for women's rights, the rights of immigrants, the fight against child labor exploitation and the quest for peace. This positioning had negative repercussions on her public image, although she was finally awarded the Nobel Peace Prize., Desde sus inicios, el trabajo social ha promovido la defensa de los derechos humanos y la justicia social. Hacerlo ha implicado también tener una influencia en el ámbito político. Aunque, en algunos contextos, la participación en la arena política de los y las trabajadoras sociales es limitada. A partir del análisis de la figura de Jane Addams, mediante un análisis bibliográfico, este estudio muestra el papel que puede desempeñar el trabajo social en el cambio de políticas y la importancia de ser coherente con los valores personales, así como de entablar un diálogo igualitario tomando como punto de partida los derechos humanos y la justicia social. Jane Addams se convirtió en una emprendedora política en campos como la lucha por los derechos de la mujer, los derechos de los inmigrantes, la lucha contra la explotación laboral infantil y la búsqueda de la paz. Este posicionamiento repercutió negativamente en su imagen pública, aunque finalmente fue galardonada con el Premio Nobel de la Paz.

Since its inception, social work has promoted the defense of human rights and social justice. Doing so has also implied having an influence in the political arena. Although, in some contexts, participation in the political arena of social workers is limited. Based on an analysis of the figure of Jane Addams, using a bibliographic analysis, this study shows the role that social work can play in changing policies and the importance of being coherent with personal values, as well as engaging in equal dialogue using human rights and social justice as a starting point. Jane Addams became a political entrepreneur in fields such as the struggle for women's rights, the rights of immigrants, the fight against child labor exploitation and the quest for peace. This positioning had negative repercussions on her public image, although she was finally awarded the Nobel Peace Prize., Desde sus inicios, el trabajo social ha promovido la defensa de los derechos humanos y la justicia social. Hacerlo ha implicado también tener una influencia en el ámbito político. Aunque, en algunos contextos, la participación en la arena política de los y las trabajadoras sociales es limitada. A partir del análisis de la figura de Jane Addams, mediante un análisis bibliográfico, este estudio muestra el papel que puede desempeñar el trabajo social en el cambio de políticas y la importancia de ser coherente con los valores personales, así como de entablar un diálogo igualitario tomando como punto de partida los derechos humanos y la justicia social. Jane Addams se convirtió en una emprendedora política en campos como la lucha por los derechos de la mujer, los derechos de los inmigrantes, la lucha contra la explotación laboral infantil y la búsqueda de la paz. Este posicionamiento repercutió negativamente en su imagen pública, aunque finalmente fue galardonada con el Premio Nobel de la Paz.

Since its inception, social work has promoted the defense of human rights and social justice. Doing so has also implied having an influence in the political arena. Although, in some contexts, participation in the political arena of social workers is limited. Based on an analysis of the figure of Jane Addams, using a bibliographic analysis, this study shows the role that social work can play in changing policies and the importance of being coherent with personal values, as well as engaging in equal dialogue using human rights and social justice as a starting point. Jane Addams became a political entrepreneur in fields such as the struggle for women's rights, the rights of immigrants, the fight against child labor exploitation and the quest for peace. This positioning had negative repercussions on her public image, although she was finally awarded the Nobel Peace Prize.

LRBA deficiency was first described in 2012 as an autosomal recessive disorder caused by biallelic mutations in the LRBA gene (OMIM #614700). It was initially characterized as producing early-onset hypogammaglobulinemia, autoimmune manifestations, susceptibility to inflammatory bowel disease, and recurrent infection. However, further reports expanded this phenotype (including patients without hypogammaglobulinemia) and described LRBA deficiency as a clinically variable syndrome with a wide spectrum of clinical manifestations. We present the case of a female patient who presented with type 1 diabetes, psoriasis, oral thrush, and enlarged liver and spleen at the age of 8 months. She later experienced recurrent bacterial and viral infections, including pneumococcal meningitis and Epstein Barr viremia. She underwent two consecutive stem cell transplants at the age of 8 and 9 years, and ultimately died. Samples from the patient and her parents were subjected to whole exome sequencing, which revealed a homozygous 1-bp insertion in exon 23 of the patient's LRBA gene, resulting in frameshift and premature stop codon. The patient's healthy mother was heterozygous for the mutation and her father tested wild-type. This finding suggested that either one copy of the paternal chromosome 4 bore a deletion including the LRBA locus, or the patient inherited two copies of the mutant maternal LRBA allele. The patient's sequencing data showed a 1-Mb loss of heterozygosity region in chromosome 4, including the LRBA gene. Comparative genomic hybridization array of the patient's and father's genomic DNA yielded normal findings, ruling out genomic copy number abnormalities. Here, we present the first case of LRBA deficiency due to a uniparental disomy (UPD). In contrast to classical Mendelian inheritance, UPD involves inheritance of 2 copies of a chromosomal region from only 1 parent. Specifically, our patient carried a small segmental isodisomy of maternal origin affecting 1 Mb of chromos

In families at risk from monogenic diseases affected offspring, it is fundamental the development of a suitable Double Factor Preimplantation Genetic Testing (DF-PGT) method for both single-gene analysis and chromosome complement screening. Aneuploidy is not only a major issue in advanced-maternal-age patients and balanced translocation carriers, but also the aneuploidy rate is extremely high in patients undergoing in vitro fertilization (IVF), even in young donors. To adequate NGS technology to the DF-PGT strategy four different whole genome amplification systems (Sureplex, MALBAC, and two multiple displacement amplification systems-MDA) were tested using TruSight One panel on cell lines and blastocyst trophectoderm biopsies-TE. Embryo cytogenetic status was analyzed by Nexus software. Sureplex and MALBAC DNA products were considered not suitable for PGT diagnosis due to inconsistent and poor results on Trusight one (TSO) panel. Results obtained with both MDA based methods (GEH-MDA and RG-MDA) were appropriate for direct mutation detection by TSO NGS platform. Nevertheless, RG-MDA amplification products showed better coverage and lower ADO rates than GEH-MDA. The present work also demonstrates that the same TSO sequencing data is suitable not only for the direct mutation detection, but also for the indirect mutation detection by linkage analysis of informative SNPs. The present work also demonstrates that Nexus software is competent for the detection of CNV by using with TSO sequencing data from RG-MDA products, allowing for the whole cytogenetic characterization of the embryos. In conclusion, successfully development of an innovative and promising DF-PGT strategy using TSO-NGS technology in TE biopsies, performed in-house in a single laboratory experience, has been done in the present work. Additional studies should be performed before it could be used as a diagnostic alternative in order to validate this approach for the detection of chromosomal aneuploidies.

Research on out‐of‐home child care has revealed that foster care programmes focused on educational attainment and reading have the potential to improve the academic outcomes of children in care. However, no studies have examined which elements of these programmes positively benefit children's emotional well‐being. This article presents evidence of the positive effects of implementing a successful educational action, dialogic literary gatherings, in a children's residential care institution. A qualitative study using a communicative‐oriented methodology was conducted and involved five participant observations and eight daily life stories with children in out‐of‐home care in Catalonia (Spain). The children's reflections demonstrated that reading classic books, such as Dickens' Oliver Twist, deeply influenced their feelings and self‐conceptions and created new and exciting meaning in their lives.

We present a theoretical analysis of the time-gated phase matching (ionization gating) mechanism in high-order harmonic generation for the isolation of attosecond pulses at near-infrared and mid-infrared driver wavelengths, for both few-cycle and multi-cycle driving laser pulses. Results of our high harmonic generation and three-dimensional propagation simulations show that broadband isolated pulses spanning from the extreme-ultraviolet well into the soft X-ray region of the spectrum can be generated for both few-cycle and multi-cycle laser pulses. We demonstrate the key role of absorption and group velocity matching for generating bright, isolated, attosecond pulses using long wavelength multi-cycle pulses. Finally, we show that this technique is robust against carrier-envelope phase and peak intensity variations.

There are many authors who have written from their passion for science and who have reflected in their works the progress of their time; Zola is one of them. From the analysis of a few zolian texts, in which we have studied the role of the machines, the aim of this paper is to show how literature becomes a tool for science and, at the same time, how science becomes literary subject., Son muchos los autores que han escrito desde su pasión por la ciencia y que han reflejado en sus obras los avances de su tiempo; Zola es uno de ellos. A partir del análisis de unos cuantos textos zolianos, en los que se ha estudiado el protagonismo de las máquinas, el objetivo de este artículo es mostrar de qué manera la literatura se convierte en un instrumento al servicio de la ciencia y, al mismo tiempo, de qué manera la ciencia se convierte en materia literaria..

We present a theoretical analysis of the time-gated phase matching (ionization gating) mechanism in high-order harmonic generation for the isolation of attosecond pulses at near-infrared and mid-infrared driver wavelengths, for both few-cycle and multi-cycle driving laser pulses. Results of our high harmonic generation and three-dimensional propagation simulations show that broadband isolated pulses spanning from the extreme-ultraviolet well into the soft X-ray region of the spectrum can be generated for both few-cycle and multi-cycle laser pulses. We demonstrate the key role of absorption and group velocity matching for generating bright, isolated, attosecond pulses using long wavelength multi-cycle pulses. Finally, we show that this technique is robust against carrier-envelope phase and peak intensity variations.

Muchos programas, en España o Europa, entienden al alumnado inmigrante como un colectivo homogéneo, aplicando soluciones iguales a todos, sin lograr promover su inclusión socio-educativa. Sin embargo, algunos países anglosajones observan diferencias en este grupo que influyen en su éxito educativo e inclusión social y cuyo conocimiento puede ayudar a promover actuaciones que atiendan mejor a esta población. El artículo describe y analiza el concepto de estudiante con escolaridad formal limitada o interrumpida y discute los factores que la escuela tiene en cuenta para fomentar su inclusión socio-educativa, abogando por una intervención holística que tenga en cuenta este alumnado necesita mucho más que centrar su aprendizaje únicamente el nuevo idioma, por ejemplo el apoyo social para superar los problemas socioemocionales que les acompañan. Resulta especialmente relevante para España y Europa, pues recientemente acuden cada vez más alumnos con estas características a nuestras escuelas.

Plasmon resonances are known to amplify the electromagnetic fields near metallic nanostructures, providing a promising scheme to generate extreme-ultraviolet harmonics using low power drivings. During high-order harmonic generation (HHG), the driving and harmonic fields accumulate a phase di erence as they propagate through the target. In a typical set-up –a laser focused into a gas jet– the propagation distances amount to several wavelengths, and the cumulative phase-mismatch a ects strongly the e ciency and properties of the harmonic emission. In contrast, HHG in metallic nanostructures is considered to overcome these limitations, as the common sources of phase mismatch –optical density and focusing geometry– are negligible for subwavelength propagation distances. We demonstrate that phase matching still plays a relevant role in HHG from nanostructures due to the non-perturbative character of HHG, that links the harmonic phase to the intensity distribution of the driving field. Our computations show that widely used applications of phase matching control, such as quantum path selection and the increase of contrast in attosecond pulse generation, are also feasible at the nanoscale.

There are many authors who have written from their passion for science and who have reflected in their works the progress of their time; Zola is one of them. From the analysis of a few zolian texts, in which we have studied the role of the machines, the aim of this paper is to show how literature becomes a tool for science and, at the same time, how science becomes literary subject., Son muchos los autores que han escrito desde su pasión por la ciencia y que han reflejado en sus obras los avances de su tiempo; Zola es uno de ellos. A partir del análisis de unos cuantos textos zolianos, en los que se ha estudiado el protagonismo de las máquinas, el objetivo de este artículo es mostrar de qué manera la literatura se convierte en un instrumento al servicio de la ciencia y, al mismo tiempo, de qué manera la ciencia se convierte en materia literaria..

Bright, circularly polarized, extreme ultraviolet (EUV) and soft x-ray high-harmonic beams can now be produced using counter-rotating circularly polarized driving laser fields. Although the resulting circularly polarized harmonics consist of relatively simple pairs of peaks in the spectral domain, in the time domain, the field is predicted to emerge as a complex series of rotating linearly polarized bursts, varying rapidly in amplitude, frequency, and polarization. We extend attosecond metrology techniques to circularly polarized light by simultaneously irradiating a copper surface with circularly polarized high-harmonic and linearly polarized infrared laser fields. The resulting temporal modulation of the photoelectron spectra carries essential phase information about the EUV field. Utilizing the polarization selectivity of the solid surface and by rotating the circularly polarized EUV field in space, we fully retrieve the amplitude and phase of the circularly polarized harmonics, allowing us to reconstruct one of the most complex coherent light fields produced to date.

We analyze the role of group-velocity matching (GVM) in the macroscopic build up of the high-harmonic signal generated in gas targets at high pressures. A definition of the walk-off length, associated with GVM, in the non-perturbative intensity regime of high-harmonic generation is given. Semiclassical predictions based on this definition are in excellent agreement with full quantum simulations. We demonstrate that group velocity matching is a relevant factor in high harmonic generation and the isolation of attosecond pulses driven by long wavelength lasers and preferentially selects contributions from the short quantum trajectories.

We analyze the role of group-velocity matching (GVM) in the macroscopic build up of the high-harmonic signal generated in gas targets at high pressures. A definition of the walk-off length, associated with GVM, in the non-perturbative intensity regime of high-harmonic generation is given. Semiclassical predictions based on this definition are in excellent agreement with full quantum simulations. We demonstrate that group velocity matching is a relevant factor in high harmonic generation and the isolation of attosecond pulses driven by long wavelength lasers and preferentially selects contributions from the short quantum trajectories.

We analyze the role of group-velocity matching (GVM) in the macroscopic build up of the high-harmonic signal generated in gas targets at high pressures. A definition of the walk-off length, associated with GVM, in the non-perturbative intensity regime of high-harmonic generation is given. Semiclassical predictions based on this definition are in excellent agreement with full quantum simulations. We demonstrate that group velocity matching is a relevant factor in high harmonic generation and the isolation of attosecond pulses driven by long wavelength lasers and preferentially selects contributions from the short quantum trajectories.

The following paper is part of a wider research about the different manifestations of experimental poetry, which was carried out by the POCIO group, affiliated with the University of Barcelona. The article aims to perform an analysis of three albums (or illustrated books) that move away from the concept of narrative text and, instead, use the enumeration procedure. The formal and textual characteristics of this kind of books are closer to other texts using the aforementioned rhetorical procedure, and pose a challenge of comprehension, assimilation, and enjoyment, which requires readers with a more complex and acute power of observation. Therefore, this type of books stresses the fact that illustrated works are not always addressed to young or inexpert readers. Hence, to perform this analysis it is needed, on one side, to stablish a paradigm of books based on lists and inventories, and on the other, to study the very concept of enumeration as a figure of speech and a visual procedure, following the pattern set by Umberto Eco and other researchers., Este trabajo se inscribe en una investigación más amplia sobre las diversas facetas de la poesía experimental que lleva a cabo el grupo POCIO adscrito a la Universidad de Barcelona. El artículo se propone efectuar el análisis de tres álbumes, libros ilustrados que se alejan del texto narrativo y utilizan el procedimiento de la enumeración. Estos libros, que por sus características formales y textuales se aproximan a otros textos que se construyen con este procedimiento retórico, plantean un reto de comprensión, asimilación y disfrute que requiere unos lectores dotados de una capacidad de observación más compleja y afinada. En consecuencia, este tipo de obras ilustradas recuerda que no siempre están dirigidas al lector infantil, o, más precisamente, al lector inexperto. Así pues, para llevar a cabo este análisis es necesario, por un lado, establecer un paradigma de los libros que se basan en listas e inventarios, y, por otro, estudiar el propio concepto de enumeración como figura retórica y procedimiento visual, siguiendo las pautas marcadas en este terreno por Umberto Eco y otros investigadores.

In the ANKA storage ring, a digital state-of-the-art Bunch-By-Bunch (BBB) feedback system provides damping of Coupled-Bunch-Instabilities (CBI) in order to increase the maximum storable beam current and lifetime. Performance of this feedback strongly depends on the phase advance in the digital Finite Impulse Response (FIR) filter. Especially during energy ramping, retuning of FIR filter parameters is required as the electron beam?s tune varies with changing machine optics. With this purpose, an algorithm for the automatic tuning of the filter is proposed. Tests performed during several energy rampings show an improvement in rejection of instabilities, which means robustness of the feedback system against changes in machine settings is enhanced. Beam lifetime is also a critical parameter to evaluate performance of the storage ring. It is related to bunch length in the longitudinal axis, which must not be too short to reduce beamloss. So as to increase bunch length and thus enhance beam lifetime, beam modulation at quadrupole resonance is applied in longitudinal axis. An algorithm for the automatic configuration of this modulation has been implemented and tested during injection. Results show a significant enhancement of beam lifetime, but reproducibility of these results will be discussed., En el anillo de almacenaje ANKA, un sistema de retroalimentación digital Paquete-Por-Paquete (Bunch-By-Bunch, BBB) de última generación proporciona la atenuación de inestabilidades derivadas del acoplamiento entre paquetes (Coupled-Bunch-Instabilities, CBI), con objeto de incrementar el máximo nivel de corriente almacenable y el tiempo de vida del haz de partículas. Las prestaciones de la retroalimentación dependen fuertemente del avance de fase introducido por el filtro digital de respuesta impulsional finita (Finite Impulse Response, FIR). De manera especial durante la rampa de energía, es necesario reajustar los parámetros del filtro FIR para compensar la variación de la frecuencia característica del haz de electrones, que cambia en relación a la óptica del acelerador (machine optics). Con este objetivo, el presente trabajo propone un algoritmo para la sintonía automática del filtro. En las pruebas llevadas a cabo durante diversas rampas de energía, se ha observado una mejora en el rechazo de las inestabilidades, de forma que se refuerza la robustez del sistema de retroalimentación frente a los cambios en la configuración del acelerador. El tiempo de vida del haz de partículas es otro parámetro crítico a la hora de evaluar las prestaciones del anillo de almacenaje. Está relacionado con la longitud del paquete en el eje longitudinal, que no debe ser demasiado corta para reducir la pérdida de partículas. Con el objetivo de incrementar la longitud del paquete y con ello, el tiempo de vida, se aplica una modulación a la frecuencia de resonancia de cuarto orden en el eje longitudinal. En este trabajo, se ha implementado un algoritmo para la configuración automática de la modulación, que se ha puesto a prueba durante la inyección. Los resultados muestran una mejora significativa en el tiempo de vida, pero se comentará la reproducibilidad de los mismos., A l’anell d’emmagatzematge ANKA, un sistema de retroalimentació digital Paquet-Per-Paquet (Bunch-By-Bunch, BBB) d’última generació proporciona l’esmorteïment d’inestabilitats derivades de l’acoblament entre paquets (Coupled-Bunch-Instabilities, CBI), per tal d’incrementar el màxim nivell de corrent emmagatzemable i el temps de vida del feix de partícules. Les prestacions de la retroalimentació depenen fortament de l’avançament de fase introduït pel filtre digital de resposta impulsional finita (Finite Impulse Response, FIR). De manera especial durant la rampa d’energia, és necessari reajustar els paràmetres del filtre FIR per tal de compensar la variació de la freqüència característica del feix d’electrons, que canvia amb la configuració de l’òptica de l’accelerador (machine optics). Amb aquest objectiu, en aquest treball es proposa un algorisme per a la sintonia automàtica del filtre. A les proves que s’han dut a terme durant diverses rampes d’energia, s’ha observat una millora en el rebuig de les inestabilitats, de manera que es reforça la robustesa del sistema de retroalimentació enfront als canvis en la configuració de l’accelerador. El temps de vida del feix de partícules és un altre paràmetre crític a l’hora d’avaluar les prestacions de l’anell d’emmagatzematge. Està relacionat amb la longitud del paquet de partícules en l’eix longitudinal, que no ha de ser massa curta per tal de reduir la pèrdua de partícules. Amb l’objectiu d’incrementar la longitud del paquet i amb això, el temps de vida, s’aplica una modulació a la freqüència de ressonància de quart ordre en l’eix longitudinal. En aquest treball, s’ha implementat un algorisme per a la configuració automàtica de la modulació, que s’ha provat durant la injecció. Els resultats mostren una millora significativa en el temps de vida, però es comentarà la reproductibilitat d’aquests resultats.

High-harmonic generation is a universal response of matter to strong femtosecond laser fields, coherently upconverting light to much shorter wavelengths. Optimizing the conversion of laser light into soft x-rays typically demands a trade-off between two competing factors. Because of reduced quantum diffusion of the radiating electron wave function, the emission from each species is highest when a short-wavelength ultraviolet driving laser is used. However, phase matching--the constructive addition of x-ray waves from a large number of atoms--favors longer-wavelength mid-infrared lasers. We identified a regime of high-harmonic generation driven by 40-cycle ultraviolet lasers in waveguides that can generate bright beams in the soft x-ray region of the spectrum, up to photon energies of 280 electron volts. Surprisingly, the high ultraviolet refractive indices of both neutral atoms and ions enabled effective phase matching, even in a multiply ionized plasma. We observed harmonics with very narrow linewidths, while calculations show that the x-rays emerge as nearly time-bandwidth-limited pulse trains of ~100 attoseconds.

La citogenètica convencional detecta un 3-5% dels pacients amb retard global del desenvolupament / discapacitat intel·lectual (RGD / DI) i / o malformacions congènites (MC). L'amplificació de sondes múltiples dependents de lligació (MLPA) permet incrementar la taxa diagnòstica entre 2,4-5,8%. Actualment els arrays d'hibridació genòmica comparada (aCGH) constitueixen l'eina diagnòstica amb major rendiment en pacients amb RGD / DI, MC i trastorns de l'espectre autista (TEA). L'objectiu del present treball ha estat avaluar l'eficiència de l'ús dels aCGH com a tècnica de primera opció diagnòstica en aquestes i altres indicacions (epilèpsia, talla baixa). Per assolir aquest objectiu, s'han estudiat 1.000 pacients afectats de les patologies abans esmentades mitjançant la tècnica de aCGH, utilitzant una estratègia d'hibridació pacient versus pacient i afegint el suport de la tècnica de MLPA en el 50% dels pacients estudiats. En primer lloc es va validar la tècnica i es va escollir la plataforma d'oligoarrays. Per tal de minimitzar costos i incrementar la eficiència, es va utilitzar l'estratègia d'hibridació de pacient versus pacient amb MLPA confirmatòria i es van establir criteris de diagnòstic per optimitzar la detecció de desequilibris patogènics. Per facilitar la interpretació dels resultats es va dissenyar un programa informàtic EasyArray. Es van detectar desequilibris d'efecte patogènic en un 14% dels pacients (140 / 1.000). En funció del fenotip es van diagnosticar un 18,9% dels pacients afectats de RGD / DI; un 13,7% de les MC; un 9,75% de les patologies psiquiàtriques, 1 7,01% dels casos amb epilèpsia i un 13,3% dels pacients amb talla baixa. Dins de les MC destaquen les del sistema nerviós central amb un 14,9% i les cardiopaties congènites amb un 10,6% de diagnòstics. Dins de les patologies psiquiàtriques, destaquen els pacients amb TEA amb un 8.9% de diagnòstics. Podem concloure que la tècnica d'arrayCGH té un rendiment diagnòstic molt superior al del cariotip a, Conventional cytogenetics diagnoses 3-5% of patients with unexplained developmental delay / intellectual disability (DD / ID) and / or multiple congenital Anomalies (MCA). Multiplex ligation probes Amplification (MLPA) increases diagnostic rate between 2.4 to 5.8%. Currently the array comparative genomic Hybridization (CGH) is the highest performing diagnostic tool in patients with DD / ID, MC and autism spectrum disorders. Our aim was to evaluate the efficiency of the use of aCGH as first-line test replacing the karyotype and MLPA in these and other pathological indications (epilepsy, short stature). A total of 1000 patients referred by one or more of the above mentioned disorders were analysed by aCGH using a methodology / strategy hybrid alternative patient versus patients adding support MLPA technique in 50% of patients studied. Following a validation period, an oligoarray platform was chosen. In order to minimize costs and increase efficiency, a patient versus patient hybridization strategy plus MLPA confirmation was used, and analysis criteria were set to optimise detection of pathogenic imbalances. In order to facilitate interpretation of results, a database application named Easy Array was designed. Pathogenic genomic imbalances were detected in 14% of the cases (140/1000), with a variable distribution of diagnosis according to the phenotypes: 18.9% of patients with DD / ID, 13.7% of MCAS, 9.75% of Psychiatric pathologies, 7.01% of patients with Epilepsy and 13.3% of patients with short Stature. Within the MCA, central nervous system abnormalities and congenital heart diseases accounted for 14.9% and 10.6% of diagnosis respectively. Among the Psychiatric disorders, patients with ASD accounted for 8.9% of diagnosis. We can conclude that Array-CGH provides a substantially higher diagnostic yield tan G-banded chromosomes analysis. Its use as first line test and the development of non-standard hybridization strategies reduces consumable costs considerably. Our r

La citogenètica convencional detecta un 3-5% dels pacients amb retard global del desenvolupament / discapacitat intel·lectual (RGD / DI) i / o malformacions congènites (MC). L'amplificació de sondes múltiples dependents de lligació (MLPA) permet incrementar la taxa diagnòstica entre 2,4-5,8%. Actualment els arrays d'hibridació genòmica comparada (aCGH) constitueixen l'eina diagnòstica amb major rendiment en pacients amb RGD / DI, MC i trastorns de l'espectre autista (TEA). L'objectiu del present treball ha estat avaluar l'eficiència de l'ús dels aCGH com a tècnica de primera opció diagnòstica en aquestes i altres indicacions (epilèpsia, talla baixa). Per assolir aquest objectiu, s'han estudiat 1.000 pacients afectats de les patologies abans esmentades mitjançant la tècnica de aCGH, utilitzant una estratègia d'hibridació pacient versus pacient i afegint el suport de la tècnica de MLPA en el 50% dels pacients estudiats. En primer lloc es va validar la tècnica i es va escollir la plataforma d'oligoarrays. Per tal de minimitzar costos i incrementar la eficiència, es va utilitzar l'estratègia d'hibridació de pacient versus pacient amb MLPA confirmatòria i es van establir criteris de diagnòstic per optimitzar la detecció de desequilibris patogènics. Per facilitar la interpretació dels resultats es va dissenyar un programa informàtic EasyArray. Es van detectar desequilibris d'efecte patogènic en un 14% dels pacients (140 / 1.000). En funció del fenotip es van diagnosticar un 18,9% dels pacients afectats de RGD / DI; un 13,7% de les MC; un 9,75% de les patologies psiquiàtriques, 1 7,01% dels casos amb epilèpsia i un 13,3% dels pacients amb talla baixa. Dins de les MC destaquen les del sistema nerviós central amb un 14,9% i les cardiopaties congènites amb un 10,6% de diagnòstics. Dins de les patologies psiquiàtriques, destaquen els pacients amb TEA amb un 8.9% de diagnòstics. Podem concloure que la tècnica d'arrayCGH té un rendiment diagnòstic molt superior al del cariotip a, Conventional cytogenetics diagnoses 3-5% of patients with unexplained developmental delay / intellectual disability (DD / ID) and / or multiple congenital Anomalies (MCA). Multiplex ligation probes Amplification (MLPA) increases diagnostic rate between 2.4 to 5.8%. Currently the array comparative genomic Hybridization (CGH) is the highest performing diagnostic tool in patients with DD / ID, MC and autism spectrum disorders. Our aim was to evaluate the efficiency of the use of aCGH as first-line test replacing the karyotype and MLPA in these and other pathological indications (epilepsy, short stature). A total of 1000 patients referred by one or more of the above mentioned disorders were analysed by aCGH using a methodology / strategy hybrid alternative patient versus patients adding support MLPA technique in 50% of patients studied. Following a validation period, an oligoarray platform was chosen. In order to minimize costs and increase efficiency, a patient versus patient hybridization strategy plus MLPA confirmation was used, and analysis criteria were set to optimise detection of pathogenic imbalances. In order to facilitate interpretation of results, a database application named Easy Array was designed. Pathogenic genomic imbalances were detected in 14% of the cases (140/1000), with a variable distribution of diagnosis according to the phenotypes: 18.9% of patients with DD / ID, 13.7% of MCAS, 9.75% of Psychiatric pathologies, 7.01% of patients with Epilepsy and 13.3% of patients with short Stature. Within the MCA, central nervous system abnormalities and congenital heart diseases accounted for 14.9% and 10.6% of diagnosis respectively. Among the Psychiatric disorders, patients with ASD accounted for 8.9% of diagnosis. We can conclude that Array-CGH provides a substantially higher diagnostic yield tan G-banded chromosomes analysis. Its use as first line test and the development of non-standard hybridization strategies reduces consumable costs considerably. Our r

High-harmonic generation is a universal response of matter to strong femtosecond laser fields, coherently upconverting light to much shorter wavelengths. Optimizing the conversion of laser light into soft x-rays typically demands a trade-off between two competing factors. Because of reduced quantum diffusion of the radiating electron wave function, the emission from each species is highest when a short-wavelength ultraviolet driving laser is used. However, phase matching--the constructive addition of x-ray waves from a large number of atoms--favors longer-wavelength mid-infrared lasers. We identified a regime of high-harmonic generation driven by 40-cycle ultraviolet lasers in waveguides that can generate bright beams in the soft x-ray region of the spectrum, up to photon energies of 280 electron volts. Surprisingly, the high ultraviolet refractive indices of both neutral atoms and ions enabled effective phase matching, even in a multiply ionized plasma. We observed harmonics with very narrow linewidths, while calculations show that the x-rays emerge as nearly time-bandwidth-limited pulse trains of ~100 attoseconds.

High harmonic generation driven by femtosecond lasers makes it possible to capture the fastest dynamics in molecules and materials. However, to date the shortest subfemtosecond (attosecond, 10(-18) s) pulses have been produced only in the extreme UV region of the spectrum below 100 eV, which limits the range of materials and molecular systems that can be explored. Here we experimentally demonstrate a remarkable convergence of physics: when midinfrared lasers are used to drive high harmonic generation, the conditions for optimal bright, soft X-ray generation naturally coincide with the generation of isolated attosecond pulses. The temporal window over which phase matching occurs shrinks rapidly with increasing driving laser wavelength, to the extent that bright isolated attosecond pulses are the norm for 2-µm driving lasers. Harnessing this realization, we experimentally demonstrate the generation of isolated soft X-ray attosecond pulses at photon energies up to 180 eV for the first time, to our knowledge, with a transform limit of 35 attoseconds (as), and a predicted linear chirp of 300 as. Most surprisingly, advanced theory shows that in contrast with as pulse generation in the extreme UV, long-duration, 10-cycle, driving laser pulses are required to generate isolated soft X-ray bursts efficiently, to mitigate group velocity walk-off between the laser and the X-ray fields that otherwise limit the conversion efficiency. Our work demonstrates a clear and straightforward approach for robustly generating bright isolated attosecond pulses of electromagnetic radiation throughout the soft X-ray region of the spectrum.

High harmonic generation driven by femtosecond lasers makes it possible to capture the fastest dynamics in molecules and materials. However, to date the shortest subfemtosecond (attosecond, 10(-18) s) pulses have been produced only in the extreme UV region of the spectrum below 100 eV, which limits the range of materials and molecular systems that can be explored. Here we experimentally demonstrate a remarkable convergence of physics: when midinfrared lasers are used to drive high harmonic generation, the conditions for optimal bright, soft X-ray generation naturally coincide with the generation of isolated attosecond pulses. The temporal window over which phase matching occurs shrinks rapidly with increasing driving laser wavelength, to the extent that bright isolated attosecond pulses are the norm for 2-µm driving lasers. Harnessing this realization, we experimentally demonstrate the generation of isolated soft X-ray attosecond pulses at photon energies up to 180 eV for the first time, to our knowledge, with a transform limit of 35 attoseconds (as), and a predicted linear chirp of 300 as. Most surprisingly, advanced theory shows that in contrast with as pulse generation in the extreme UV, long-duration, 10-cycle, driving laser pulses are required to generate isolated soft X-ray bursts efficiently, to mitigate group velocity walk-off between the laser and the X-ray fields that otherwise limit the conversion efficiency. Our work demonstrates a clear and straightforward approach for robustly generating bright isolated attosecond pulses of electromagnetic radiation throughout the soft X-ray region of the spectrum.

El recorregut professional d’en Salvi Plaja és sens dubte ric en experiències i inspirador pels futurs professionals, com avala la seva trajectòria professional. En l'any 1999 es gradua com Enginyer de Disseny Industrial i Desenvolupament del Producte a la UdG i comença a treballar a BRAUN, on participa en el desenvolupament d’un nou concepte propi de MINIPIMER amb la conseqüent generació de patents i prototipus funcional. Al 2000 s’incorpora a I.E.P. Il·luminació i, entre 2002 i 2007, treballa com a enginyer de producte a Troll Luxiona, on desenvolupa tasques de disseny realitzant nous productes, càlcul i disseny de reflectors i projectes especials amb Jean Nouvel (parc Poble Nou), Herzog & Demeuron (Edifici Fòrum) i David Chiperfield (Ciutat Judicial) entre d’altres. Des del 2012 en Salvi Plaja és Design Manager a Simon Tech empresa dedicada a donar servei de I+D+i a tot el grup Simon, en un període anterior, entre 2007 i 2008 ja havia sigut responsable del Grup de I+D a SIMONLighting. Entremig, entre 2008 i 2012, va ser Director Tècnic i Industrial a Santa & Cole., El recorregut professional d’en Salvi Plaja és sens dubte ric en experiències i inspirador pels futurs professionals, com avala la seva trajectòria professional. En l'any 1999 es gradua com Enginyer de Disseny Industrial i Desenvolupament del Producte a la UdG i comença a treballar a BRAUN, on participa en el desenvolupament d’un nou concepte propi de MINIPIMER amb la conseqüent generació de patents i prototipus funcional. Al 2000 s’incorpora a I.E.P. Il·luminació i, entre 2002 i 2007, treballa com a enginyer de producte a Troll Luxiona, on desenvolupa tasques de disseny realitzant nous productes, càlcul i disseny de reflectors i projectes especials amb Jean Nouvel (parc Poble Nou), Herzog & Demeuron (Edifici Fòrum) i David Chiperfield (Ciutat Judicial) entre d’altres. Des del 2012 en Salvi Plaja és Design Manager a Simon Tech empresa dedicada a donar servei de I+D+i a tot el grup Simon, en un període anterior, entre 2007 i 2008 ja havia sigut responsable del Grup de I+D a SIMONLighting. Entremig, entre 2008 i 2012, va ser Director Tècnic i Industrial a Santa & Cole.

Adaptive Energy Management front-ends for Wireless Power Transfer and frequency Optimization of Assymetric WPT Links., [ANGLÈS] Resonant Inductive Coupling Wireless Power Transfer (RIC-WPT) is a leading field of research due to the growing number of applications that can benefit from this technology: from biomedical implants to consumer electronics, fractionated spacecraft and electric vehicles amongst others. However, current applications are limited to symmetric point-to-point-links. New applications of RIC-WPT emphasize the necessity to explore these links for different configurations: asymmetrical systems and multi-point RIC-WPT networks. Prediction of their behaviour and optimization of these links are required before their deployment; and correction of performance and adaptation to operation conditions are necessary to enhance power transfer once the link is operative. Besides, application of these new configurations requires a revision of existing models to ensure that analytical description matches actual behaviour of both antennas and the complete RIC-WPT link. In this work, regarding aforementioned points, a critical comparison of antenna and link models is performed to guarantee model to actual behaviour correlation. Regarding verified models, response of a RIC-WPT link is characterized for different coupling scenarios to predict its behaviour. Then a design methodology to optimize an asymmetric RIC-WPT link is presented. Finally, an adaptive energy management system is proposed to enhance operation conditions once the link has been deployed., [CASTELLÀ] La transferencia de energía sin cables por acoplamiento resonante inductivo (RIC-WPT) es un campo de investigación líder debido al creciente número de aplicacions que se benefician de esta tecnología: desde implantes biomédicos hasta la electrónica de consumo, tecnología aeroespacial fraccionada y vehículos eléctricos entre otras. Sin embargo, las aplicaciones actuales se limitan a enlaces simétricos punto a punto. Las nuevas aplicaciones de RIC-WPT enfatizan la necesidad de explorar este tipo de enlaces para otras configuraciones: sistemas asimétricos y redes RIC-WPT multipunto. Es necesario predecir su comportamiento y optimizarlos antes de su desplegamiento; una vez el enlace está operativo, es necesario corregir su rendimiento y garantizar la adaptación a las condiciones de trabajo para mejorar la transferencia de potencia. Además, la aplicación de estas nuevas configuraciones requiere la revisión de los modelos existentes para garantizar que la descripción analítica se corresponde con el comportamiento real, tanto en el caso de la antena como el del enlace RIC-WPT al completo. En este trabajo, según los puntos anteriores, se presenta una comparación crítica de los modelos que describen la antena y el enlace RIC-WPT para garantizar su correlación con el comportamiento real. Una vez esto se ha verificado, se caracteriza la respuesta del enlace RIC-WPT en distintos escenarios de acoplamiento para predecir su comportamiento. Después, se presenta una metodología de diseño orientada a optimizar un enlace RIC-WPT asimétrico. Finalmente, se propone un sistema de gestión adaptativo de energía con el objetivo de mejorar las condiciones de operación en un enace ya implementado., [CATALÀ] La transferència d’energia sense cables per acoblament ressonant inductiu (RIC-WPT) és un camp de recerca capdavanter degut al creixent nombre d’apliacions que es beneficien d’aquesta tecnologia: des d’implants biomèdics fins a l’electrònica de consum, tecnologia aeroespacial fraccionada i vehicles elèctrics entre d’altres. Tot i així, les aplicacions actuals es limiten a enllaços simètrics punt a punt. Les noves aplicacions de RIC-WPT emfatitzen la necessitat d’explorar aquest tipus d’enllaços per a d’altres configuracions: sistemes asimètrics i xarxes RIC-WPT multipunt. És necessari predir el seu comportament i optimitzar-los abans de fer-ne el desplegament; un cop l’enllaç és operatiu, és necessari corregir-ne el rendiment i garantir-ne l’adaptació a les condicions de treball per tal de millorar la transferència de potència. A més d’això, l’aplicació d’aquestes noves configuracions requereix la revisió dels models existents per tal de garantir que la descripció analítica es correspon amb el comportament real, tant en el cas de l’antena com el de l’enllaç RIC-WPT al complet. En aquest treball, tot seguint els punts anteriors, es presenta una comparació crítica dels models per a descriure l’antena i l’enllaç RIC-WPT per tal de garantir-ne la correlació amb el comportament real. Un cop verificada, es caracteritza la resposta de l’enllaç RIC-WPT per a diferents escenaris d’acoblament per a predir-ne el comportament. Després, es presenta una metodologia de disseny per a la optimització d’un enllaç RIC-WPT asimètric. Finalment, es proposa un sistema de gestió adaptativa d’energia amb l’objectiu de millorar les condicions d’operació en un enllaç ja implementat.

We report on the analysis of the spatial beam profile of high-order harmonic radiation originating from a semi-infinite gas cell (SIGC). We experimentally assign contributions of electron trajectories to different spatial regions of the harmonic radiation beam. The angular divergence of the harmonic radiation is studied for the first time in a SIGC as a function of different phase-matching parameters. We relate the ratio of the dipole phase coefficients to the coherence time and divergence angle measurements. Simulations, including high-order-harmonic propagation, give further insight into the generation process and the influence of phase matching. The analysis reveals that the SIGC enables tuning of the cutoff frequency by altering the absorption of the generating medium. © 2013 American Physical Society.

El daño axonal difuso (DAD) en los traumatismos cráneo-encefálicos (TCE) se produce como consecuencia de daño axonal primario y secundario. Es el responsable de la mayoría de las alteraciones de atención, memoria, velocidad de procesamiento y alteraciones ejecutivas en los TCE moderados y graves. Las técnicas de resonancia magnética clínicas permiten visualizar las microhemorragias en secuencias de T2*clásicas y permiten evaluarlo de forma indirecta mediante las medidas de volumen del sistema ventricular y de superficie del cuerpo calloso. Las imágenes de tensor de difusión (ITD) son las idóneas para identificar y cuantificar el DAD. Los valores de anisotropía fraccional (AF) han demostrado ser sensibles incluso en TCE leves y a partir de las pocas horas tras el TCE y correlacionan con parámetros de gravedad tales como la escala de coma de Glasgow o la amnesia postraumática. Los decrementos de AF evolucionan con el tiempo pero parecen permanecer como secuelas definitivas de los TCE graves incluso en niños. Las correlaciones de la ITD con los trastornos neuropsicológicos han mostrado que en especial los valores de AF en el cuerpo calloso y las medidas globales de AF de todo el cerebro reflejan las secuelas clásicas de los TCE difusos., Diffuse axonal injury (DAI) in traumatic brain injury (TBI) is produced by primary and secondary mechanisms of axonal damage. DAI is the responsible of neuropsychological impairments associated to moderate and diffuse TBI such as deficits in attention, memory, speed of mental processing and executive functions. Clinical magnetic resonance imaging allows to identify traumatic microbleeds using T2* and to quantify indirect signs of DAI such as the ventricular volumes of corpus callosum surface. Diffusion tensor imaging (DTI) is the most suitable technique to identify and to quantify DAI in TBI patients. The fractional anisotropy (FA) values have been found sensitive to DAI even in mild TBI and correlate with severity parameters such as Glasgow coma scale and post-traumatic amnesia. FA values changes over time but it remains as a permanent TBI sequel even in children. The mean whole brain FA and corpus callosum measures have shown significant correlations with the classical neuropsychological deficits seen in TBI patients with DAI.

Consultable des del TDX, Títol obtingut de la portada digitalitzada, Se ha analizado la frecuencia, localización y posible significado de los dobleces presentes en los cromosomas mitóticos obtenidos con técnicas citogenéticas convencionales. No se trata de un fenómeno aleatorio y los dobleces cromosómicos pueden ser remanentes de una disposición del cromosoma interfásico, facilitando la implicación de ciertas bandas frente a otras en reorganizaciones cromosómicas tales como los fragmentos isoacéntricos y contribuyendo a la elevada frecuencia de deleciones intersticiales e inversiones duplicaciones isodicéntricas de la región 15q11q13. Se han analizado 2262 dobleces centroméricos y 2718 dobleces no centroméricos de cultivos de sangre periférica pertenecientes a 11 individuos de ambos sexos. La frecuencia de los dobleces centroméricos se correlaciona con la longitud relativa de los cromosomas y se han identificado al menos 69 bandas no centroméricas que se doblan con una frecuencia superior a la esperada por azar. El doblez no centromérico más frecuente en las metafases obtenidas a partir de cultivos de linfocitos está situado en 15q11q13, una región bien conocida por su inestabilidad y cuya deleción es una causa frecuente de los síndromes de Prader Willi y Angelman. Estudios de FISH y alta resolución demuestran que el doblez se circunscribe a la banda 15q12. El análisis de metafases obtenidas a partir de líquido amniótico (867 dobleces centroméricos y 1118 no centroméricos) y cultivos de vellosidad corial (737 dobleces centroméricos y 874 no centroméricos) confirman los hallazgos en linfocitos con dos notables discrepancias: en líquido amniótico y vellosidad corial, el doblez 15q11q13 es mucho menos frecuente y los dobleces en Xq21 y Xq22 son mucho más frecuentes, especialmente en las hembras. Un estudio adicional en 100 metafases consecutivas de sangre, líquido amniótico y vellosidad corial confirman estas diferencias entre tejidos. Nuestra hipótesis es que los cromosomas se doblan de forma invariable en el núcleo interfásico, pero q, We have investigated the frequency, localization and possible significance of bends in mitotic chromosomes in conventional cytogenetic preparations. Bends are not a random phenomena, they may be remnants of a folded chromosome state in the nucleus and may facilitate the preferential involvement of some chromosomal bands in structural reorganizations such as the isoacentric fragments or contribute to the high frequency of interstitial deletions and isodicentric inversion duplications involving the 15q11q13 region. A total of 2262 centromeric and 2718 non-centromeric bends from blood cultures of 11 individuals were recorded. Centromeric bends frequency correlates with relative chromosome length and 69 non-centromeric sites were found not to bend at random. 15q11-13, an unstable chromosome region frequently deleted in patients with Prader Willi or Angelman syndrome, shows the highest bending frequency. FISH and high-resolution cytogenetic studies localize this bend on 15q12. All these findings in lymphocyte cultures are confirmed in amniotic fluid (867 centromeric and 1118 non-centromeric bends analyzed) and corion villus cultures (737 centromeric and 874 non-centromeric bends analyzed) with two important divergences: amniotic fluid and corion villus cultures show a lower frequency of bending on 15q11-13 and a higher frequency of bending on Xq21 as compared with lymphocyte cultures. These differences were confirmed in an independent study performed on 100 consecutive metaphases of blood, amniotic fluid and corion villus cultures. We propose the hypothesis that these bends are present in all interphasic chromosomes and delayed replication regions have less time to rectify them, so having a higher probability of being observed in metaphase. Several evidences support the idea that mitotic bends may be remnants of a folded chromosome state in the nucleus: - The striking correspondence between our bending data and the model of the intranuclear arrangement of human chromosom

Consultable des del TDX, Títol obtingut de la portada digitalitzada, Se ha analizado la frecuencia, localización y posible significado de los dobleces presentes en los cromosomas mitóticos obtenidos con técnicas citogenéticas convencionales. No se trata de un fenómeno aleatorio y los dobleces cromosómicos pueden ser remanentes de una disposición del cromosoma interfásico, facilitando la implicación de ciertas bandas frente a otras en reorganizaciones cromosómicas tales como los fragmentos isoacéntricos y contribuyendo a la elevada frecuencia de deleciones intersticiales e inversiones duplicaciones isodicéntricas de la región 15q11q13. Se han analizado 2262 dobleces centroméricos y 2718 dobleces no centroméricos de cultivos de sangre periférica pertenecientes a 11 individuos de ambos sexos. La frecuencia de los dobleces centroméricos se correlaciona con la longitud relativa de los cromosomas y se han identificado al menos 69 bandas no centroméricas que se doblan con una frecuencia superior a la esperada por azar. El doblez no centromérico más frecuente en las metafases obtenidas a partir de cultivos de linfocitos está situado en 15q11q13, una región bien conocida por su inestabilidad y cuya deleción es una causa frecuente de los síndromes de Prader Willi y Angelman. Estudios de FISH y alta resolución demuestran que el doblez se circunscribe a la banda 15q12. El análisis de metafases obtenidas a partir de líquido amniótico (867 dobleces centroméricos y 1118 no centroméricos) y cultivos de vellosidad corial (737 dobleces centroméricos y 874 no centroméricos) confirman los hallazgos en linfocitos con dos notables discrepancias: en líquido amniótico y vellosidad corial, el doblez 15q11q13 es mucho menos frecuente y los dobleces en Xq21 y Xq22 son mucho más frecuentes, especialmente en las hembras. Un estudio adicional en 100 metafases consecutivas de sangre, líquido amniótico y vellosidad corial confirman estas diferencias entre tejidos. Nuestra hipótesis es que los cromosomas se doblan de forma invariable en el núcleo interfásico, pero q, We have investigated the frequency, localization and possible significance of bends in mitotic chromosomes in conventional cytogenetic preparations. Bends are not a random phenomena, they may be remnants of a folded chromosome state in the nucleus and may facilitate the preferential involvement of some chromosomal bands in structural reorganizations such as the isoacentric fragments or contribute to the high frequency of interstitial deletions and isodicentric inversion duplications involving the 15q11q13 region. A total of 2262 centromeric and 2718 non-centromeric bends from blood cultures of 11 individuals were recorded. Centromeric bends frequency correlates with relative chromosome length and 69 non-centromeric sites were found not to bend at random. 15q11-13, an unstable chromosome region frequently deleted in patients with Prader Willi or Angelman syndrome, shows the highest bending frequency. FISH and high-resolution cytogenetic studies localize this bend on 15q12. All these findings in lymphocyte cultures are confirmed in amniotic fluid (867 centromeric and 1118 non-centromeric bends analyzed) and corion villus cultures (737 centromeric and 874 non-centromeric bends analyzed) with two important divergences: amniotic fluid and corion villus cultures show a lower frequency of bending on 15q11-13 and a higher frequency of bending on Xq21 as compared with lymphocyte cultures. These differences were confirmed in an independent study performed on 100 consecutive metaphases of blood, amniotic fluid and corion villus cultures. We propose the hypothesis that these bends are present in all interphasic chromosomes and delayed replication regions have less time to rectify them, so having a higher probability of being observed in metaphase. Several evidences support the idea that mitotic bends may be remnants of a folded chromosome state in the nucleus: - The striking correspondence between our bending data and the model of the intranuclear arrangement of human chromosom

Item does not contain fulltext, We present three patients with variegated aneuploidy and premature centromere division (PCD), a rare chromosomal abnormality in humans. Comparison of these three and eight other patients with variegated aneuploidy related to PCD demonstrates a phenotype comprising most frequently microcephaly, CNS anomalies (with cerebellar affection and migration defects), mental retardation, pre-and postnatal growth retardation, flat and broad nasal bridge, apparently low-set ears, eye and skin abnormalities, and ambiguous genitalia in male patients. The occurrence of Wilms tumor in three patients, rhabdomyosarcoma in two others and acute leukemia in a fifth characterizes this condition as a chromosome or genome instability disorder with a high risk of malignancy. FISH studies in uncultured blood and buccal smear cells demonstrate that the random aneuploidies are not limited to cultured cells, but also occur in vivo.

Item does not contain fulltext, We present three patients with variegated aneuploidy and premature centromere division (PCD), a rare chromosomal abnormality in humans. Comparison of these three and eight other patients with variegated aneuploidy related to PCD demonstrates a phenotype comprising most frequently microcephaly, CNS anomalies (with cerebellar affection and migration defects), mental retardation, pre-and postnatal growth retardation, flat and broad nasal bridge, apparently low-set ears, eye and skin abnormalities, and ambiguous genitalia in male patients. The occurrence of Wilms tumor in three patients, rhabdomyosarcoma in two others and acute leukemia in a fifth characterizes this condition as a chromosome or genome instability disorder with a high risk of malignancy. FISH studies in uncultured blood and buccal smear cells demonstrate that the random aneuploidies are not limited to cultured cells, but also occur in vivo.

Item does not contain fulltext, We present three patients with variegated aneuploidy and premature centromere division (PCD), a rare chromosomal abnormality in humans. Comparison of these three and eight other patients with variegated aneuploidy related to PCD demonstrates a phenotype comprising most frequently microcephaly, CNS anomalies (with cerebellar affection and migration defects), mental retardation, pre-and postnatal growth retardation, flat and broad nasal bridge, apparently low-set ears, eye and skin abnormalities, and ambiguous genitalia in male patients. The occurrence of Wilms tumor in three patients, rhabdomyosarcoma in two others and acute leukemia in a fifth characterizes this condition as a chromosome or genome instability disorder with a high risk of malignancy. FISH studies in uncultured blood and buccal smear cells demonstrate that the random aneuploidies are not limited to cultured cells, but also occur in vivo.