1. Cognitive and emotional predictors of quality of life and functioning after COVID-19
- Author
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Universitat Politècnica de Catalunya. Departament de Ciències de la Computació, NAUTILUS Project Collaborative Group, Universitat Politècnica de Catalunya. IDEAI-UPC - Intelligent Data sciEnce and Artificial Intelligence Research Group, Ariza González, Mar, Cano Marco, Neus, Segura Fàbregas, Bàrbara, Béjar Alonso, Javier, Barrué Subirana, Cristian, Cortés García, Claudio Ulises, Junqué Plaja, Carme, Garolera Freixa, Maite, Universitat Politècnica de Catalunya. Departament de Ciències de la Computació, NAUTILUS Project Collaborative Group, Universitat Politècnica de Catalunya. IDEAI-UPC - Intelligent Data sciEnce and Artificial Intelligence Research Group, Ariza González, Mar, Cano Marco, Neus, Segura Fàbregas, Bàrbara, Béjar Alonso, Javier, Barrué Subirana, Cristian, Cortés García, Claudio Ulises, Junqué Plaja, Carme, and Garolera Freixa, Maite
- Abstract
Objective: A long-term decline in health-related quality of life (HRQoL) has been reported after coronavirus disease 2019 (COVID-19). Studies with people with persistent symptoms showed inconsistent outcomes. Cognition and emotion are important determinants in HRQoL, but few studies have examined their prognostic significance for HRQoL and functionality in post-COVID patients with persisting symptoms. We aimed to describe QoL, HRQoL, and functioning in individuals post-COVID with varying COVID-19 severities and to investigate the predictive value of cognitive and emotional variables for QoL, HRQoL, and functioning. Methods: In total, 492 participants (398 post-COVID and 124 healthy controls) underwent a neurobehavioral examination that included assessments of cognition, mood, QoL/HRQoL (WHOQOL-BREF, EQ-5D), and functioning (WHODAS-II). Analysis of covariance and linear regression models were used to study intergroup differences and the relationship between cognitive and emotional variables and QoL and functioning. Results: The Physical and Psychological dimensions of WHOQoL, EQ-5D, and WHODAS Cognition, Mobility, Life Activities, and Participation dimensions were significantly lower in post-COVID groups compared with a control group. Regression models explaining 23.9%–53.9% of variance were obtained for the WHOQoL-BREF dimensions and EQ-5D, with depressive symptoms, post-COVID symptoms, employment status, income, and mental speed processing as main predictors. For the WHODAS, models explaining 17%–60.2% of the variance were obtained. Fatigue, depressive symptoms, mental speed processing, and post-COVID symptoms were the main predictors. Interpretation: QoL/HRQoL and functioning after COVID-19 in individuals with persistent symptoms were lower than in non-affected persons. Depressive symptoms, fatigue, and slower mental processing speed were predictors of lower QoL/HRQoL and functioning., This research was supported by the Agency for Management of University and Research Grants (AGAUR) from the Generalitat de Catalunya (Pandemies, 202PANDE00053) and La Marató de TV3 Foundation (202111-30-31-32)., Peer Reviewed, Membres del NAUTILUS-Project Collaborative Group: Jose A. Bernia, Servei d’Anestesia Reanimacio i Clinica del Dolor, Consorci Sanitari de Terrassa (CST) (Terrassa,Barcelona, Spain); Vanesa Arauzo, Servei de Medicina Intensiva, Consorci Sanitari de Terrassa (CST) (Terrassa, Barcelona, Spain); Marta Balague-Marmaña, Hospital Sant Joan Despı Moises Broggi, Consorci Sanitari Integral (Sant Joan Despı, Spain); Cristian Perez-Pellejero, Hospital Sant Joan Despı Moises Broggi, Consorci Sanitari Integral (Sant Joan Despı, Barcelona, Spain); Silvia Cañizares, Hospital Clinic de Barcelona (Barcelona, Spain); Jose Antonio Lopez Muñoz, Occupational Health CareService, Hospital Clınic (Barcelona, Spain); Jesus Caballero, Hospital Universitari Arnau de Vilanova (Lleida, Spain); Anna Carnes-Vendrell, Hospital Universitari de Santa Maria (Lleida, Spain); Gerard Piñol-Ripoll, Hospital Universitari de Santa Maria (Lleida, Spain); Ester Gonzalez-Aguado, Consorci Sanitari Alt Penedes-Garraf (Vilafranca de Penedes, Barcelona, Spain); Carme Tayo-Juli, Consorci Sanitari Alt Penedes-Garraf (Vilafranca de Penedes, Barcelona, Spain); Eva Forcadell-Ferreres, Hospital Verge de la Cinta,(Tortosa, Tarragona, Spain); Silvia Reverte-Vilarroya, Hospital Verge de la Cinta, (Tortosa, Tarragona, Spain); Susanna Forne, Fundacio Sant Hospital de la Seu d’Urgell (La Seu d’Urgell, Lleida, Spain); Jordina Muñoz-Padros, Consorci Hospitalari de Vic (Vic, Barcelona, Spain); Anna Bartes-Plan, Consorci Hospitalari de Vic (Vic,Barcelona, Spain); Jose A. Muñoz-Moreno, Servei de Malalties Infeccioses, Fundacio Lluita contra les Infeccions - Hospital Universitari Germans Trias i Pujol (Badalona, Barcelona, Spain); Anna Prats-Paris, Servei de Malalties Infeccioses, Fundacio Lluita contra les Infeccions - Hospital Universitari Germans Trias i Pujol (Badalona, Barcelona, Spain); Anna Gasa-Roque, Hospital Universitari de Bellvitge (L’Hospitalet de Llobregat, Barcelona, Spain); Laura Casas Valls, Hospital Universitari d, Postprint (published version)
- Published
- 2024