1. Toward a comprehensive view of cancer immune responsiveness: a synopsis from the SITC workshop
- Author
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Massachusetts Institute of Technology. Department of Biology, Koch Institute for Integrative Cancer Research at MIT, Bedognetti, Davide, Ceccarelli, Michele, Galluzzi, Lorenzo, Lu, Rongze, Palucka, Karolina, Samayoa, Josue, Spranger-Zimmermann, Stefani, Warren, Sarah, Wong, Kwok-Kin, Ziv, Elad, Chowell, Diego, Coussens, Lisa M., De Carvalho, Daniel D., DeNardo, David G., Galon, Jérôme, Kaufman, Howard L., Kirchhoff, Tomas, Lotze, Michael T., Luke, Jason J., Minn, Andy J., Politi, Katerina, Shultz, Leonard D., Simon, Richard, Thórsson, Vésteinn, Weidhaas, Joanne B., Ascierto, Maria Libera, Ascierto, Paolo Antonio, Barnes, James M., Barsan, Valentin, Bommareddy, Praveen K., Bot, Adrian, Church, Sarah E., Ciliberto, Gennaro, De Maria, Andrea, Draganov, Dobrin, Ho, Winson S., McGee, Heather M., Monette, Anne, Murphy, Joseph F., Nisticò, Paola, Park, Wungki, Patel, Maulik, Quigley, Michael, Radvanyi, Laszlo, Raftopoulos, Harry, Rudqvist, Nils-Petter, Snyder, Alexandra, Sweis, Randy F., Valpione, Sara, Zappasodi, Roberta, Butterfield, Lisa H., Disis, Mary L., Fox, Bernard A., Cesano, Alessandra, Marincola, Francesco M., Massachusetts Institute of Technology. Department of Biology, Koch Institute for Integrative Cancer Research at MIT, Bedognetti, Davide, Ceccarelli, Michele, Galluzzi, Lorenzo, Lu, Rongze, Palucka, Karolina, Samayoa, Josue, Spranger-Zimmermann, Stefani, Warren, Sarah, Wong, Kwok-Kin, Ziv, Elad, Chowell, Diego, Coussens, Lisa M., De Carvalho, Daniel D., DeNardo, David G., Galon, Jérôme, Kaufman, Howard L., Kirchhoff, Tomas, Lotze, Michael T., Luke, Jason J., Minn, Andy J., Politi, Katerina, Shultz, Leonard D., Simon, Richard, Thórsson, Vésteinn, Weidhaas, Joanne B., Ascierto, Maria Libera, Ascierto, Paolo Antonio, Barnes, James M., Barsan, Valentin, Bommareddy, Praveen K., Bot, Adrian, Church, Sarah E., Ciliberto, Gennaro, De Maria, Andrea, Draganov, Dobrin, Ho, Winson S., McGee, Heather M., Monette, Anne, Murphy, Joseph F., Nisticò, Paola, Park, Wungki, Patel, Maulik, Quigley, Michael, Radvanyi, Laszlo, Raftopoulos, Harry, Rudqvist, Nils-Petter, Snyder, Alexandra, Sweis, Randy F., Valpione, Sara, Zappasodi, Roberta, Butterfield, Lisa H., Disis, Mary L., Fox, Bernard A., Cesano, Alessandra, and Marincola, Francesco M.
- Abstract
Tumor immunology has changed the landscape of cancer treatment. Yet, not all patients benefit as cancer immune responsiveness (CIR) remains a limitation in a considerable proportion of cases. The multifactorial determinants of CIR include the genetic makeup of the patient, the genomic instability central to cancer development, the evolutionary emergence of cancer phenotypes under the influence of immune editing, and external modifiers such as demographics, environment, treatment potency, co-morbidities and cancer-independent alterations including immune homeostasis and polymorphisms in the major and minor histocompatibility molecules, cytokines, and chemokines. Based on the premise that cancer is fundamentally a disorder of the genes arising within a cell biologic process, whose deviations from normality determine the rules of engagement with the host's response, the Society for Immunotherapy of Cancer (SITC) convened a task force of experts from various disciplines including, immunology, oncology, biophysics, structural biology, molecular and cellular biology, genetics, and bioinformatics to address the complexity of CIR from a holistic view. The task force was launched by a workshop held in San Francisco on May 14-15, 2018 aimed at two preeminent goals: 1) to identify the fundamental questions related to CIR and 2) to create an interactive community of experts that could guide scientific and research priorities by forming a logical progression supported by multiple perspectives to uncover mechanisms of CIR. This workshop was a first step toward a second meeting where the focus would be to address the actionability of some of the questions identified by working groups. In this event, five working groups aimed at defining a path to test hypotheses according to their relevance to human cancer and identifying experimental models closest to human biology, which include: 1) Germline-Genetic, 2) Somatic-Genetic and 3) Genomic-Transcriptional contributions to CIR, 4) Dete
- Published
- 2020