1. Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity
- Author
-
Massachusetts Institute of Technology. Department of Biology, Whitehead Institute for Biomedical Research, Sheppard, Hadley E, Dall’Agnese, Alessandra, Park, Woojun D, Shamim, M Hamza, Dubrulle, Julien, Johnson, Hannah L, Stossi, Fabio, Cogswell, Patricia, Sommer, Josh, Levy, Joan, Sharifnia, Tanaz, Wawer, Mathias J, Nabet, Behnam, Gray, Nathanael S, Clemons, Paul A, Schreiber, Stuart L, Workman, Paul, Young, Richard A, Lin, Charles Y, Massachusetts Institute of Technology. Department of Biology, Whitehead Institute for Biomedical Research, Sheppard, Hadley E, Dall’Agnese, Alessandra, Park, Woojun D, Shamim, M Hamza, Dubrulle, Julien, Johnson, Hannah L, Stossi, Fabio, Cogswell, Patricia, Sommer, Josh, Levy, Joan, Sharifnia, Tanaz, Wawer, Mathias J, Nabet, Behnam, Gray, Nathanael S, Clemons, Paul A, Schreiber, Stuart L, Workman, Paul, Young, Richard A, and Lin, Charles Y
- Abstract
© 2020 The Authors Sheppard et al. map the brachyury regulatory landscape in chordoma and explore its targeting using transcriptional CDK inhibition and targeted brachyury degradation. Brachyury is a highly selective transcriptional regulator of chordoma identity, and they confirm that brachyury targeting is a promising therapeutic strategy.
- Published
- 2021