23 results on '"Park, SJ"'
Search Results
2. Role of helicity in the nonenzymatic template-directed primer extension of DNA
- Author
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Park, SJ, Callaghan, KL, Ellis, AV, Park, SJ, Callaghan, KL, and Ellis, AV
- Abstract
Complexing a DNA primer with an RNA template showed improved nonenzymatic template-directed primer extension, attributed to a shift in the DNA helicity from a B-type towards an A-type helix. A 2-fold (deoxyadenosine) and 4.5-fold (deoxycytidine) increase in conversion from initial DNA primer to a primer + 1 nucleotide product was observed.
- Published
- 2023
3. Acceptance and Perception of Artificial Intelligence Usability in Eye Care (APPRAISE) for Ophthalmologists: A Multinational Perspective
- Author
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Gunasekeran, DVV, Zheng, F, Lim, GYS, Chong, CCY, Zhang, S, Ng, WY, Keel, S, Xiang, Y, Park, KH, Park, SJ, Chandra, A, Wu, L, Campbel, JP, Lee, AYY, Keane, PAA, Denniston, A, Lam, DSC, Fung, ATT, Chan, PRV, Sadda, SR, Loewenstein, A, Grzybowski, A, Fong, KCS, Wu, W-C, Bachmann, LM, Zhang, X, Yam, JC, Cheung, CYY, Pongsachareonnont, P, Ruamviboonsuk, P, Raman, R, Sakamoto, T, Habash, R, Girard, M, Milea, D, Ang, M, Tan, GSW, Schmetterer, L, Cheng, C-Y, Lamoureux, E, Lin, H, van Wijngaarden, P, Wong, TYY, Ting, DSW, Gunasekeran, DVV, Zheng, F, Lim, GYS, Chong, CCY, Zhang, S, Ng, WY, Keel, S, Xiang, Y, Park, KH, Park, SJ, Chandra, A, Wu, L, Campbel, JP, Lee, AYY, Keane, PAA, Denniston, A, Lam, DSC, Fung, ATT, Chan, PRV, Sadda, SR, Loewenstein, A, Grzybowski, A, Fong, KCS, Wu, W-C, Bachmann, LM, Zhang, X, Yam, JC, Cheung, CYY, Pongsachareonnont, P, Ruamviboonsuk, P, Raman, R, Sakamoto, T, Habash, R, Girard, M, Milea, D, Ang, M, Tan, GSW, Schmetterer, L, Cheng, C-Y, Lamoureux, E, Lin, H, van Wijngaarden, P, Wong, TYY, and Ting, DSW
- Abstract
BACKGROUND: Many artificial intelligence (AI) studies have focused on development of AI models, novel techniques, and reporting guidelines. However, little is understood about clinicians' perspectives of AI applications in medical fields including ophthalmology, particularly in light of recent regulatory guidelines. The aim for this study was to evaluate the perspectives of ophthalmologists regarding AI in 4 major eye conditions: diabetic retinopathy (DR), glaucoma, age-related macular degeneration (AMD) and cataract. METHODS: This was a multi-national survey of ophthalmologists between March 1st, 2020 to February 29th, 2021 disseminated via the major global ophthalmology societies. The survey was designed based on microsystem, mesosystem and macrosystem questions, and the software as a medical device (SaMD) regulatory framework chaired by the Food and Drug Administration (FDA). Factors associated with AI adoption for ophthalmology analyzed with multivariable logistic regression random forest machine learning. RESULTS: One thousand one hundred seventy-six ophthalmologists from 70 countries participated with a response rate ranging from 78.8 to 85.8% per question. Ophthalmologists were more willing to use AI as clinical assistive tools (88.1%, n = 890/1,010) especially those with over 20 years' experience (OR 3.70, 95% CI: 1.10-12.5, p = 0.035), as compared to clinical decision support tools (78.8%, n = 796/1,010) or diagnostic tools (64.5%, n = 651). A majority of Ophthalmologists felt that AI is most relevant to DR (78.2%), followed by glaucoma (70.7%), AMD (66.8%), and cataract (51.4%) detection. Many participants were confident their roles will not be replaced (68.2%, n = 632/927), and felt COVID-19 catalyzed willingness to adopt AI (80.9%, n = 750/927). Common barriers to implementation include medical liability from errors (72.5%, n = 672/927) whereas enablers include improving access (94.5%, n = 876/927). Machine learning modeling predicted acceptance from par
- Published
- 2022
4. Stroke After Coronary Artery Bypass Grafting and Percutaneous Coronary Intervention: Incidence, Pathogenesis, and Outcomes
- Author
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Gaudino, M, Angiolillo, DJ, Di Franco, A, Capodanno, D, Bakaeen, F, Farkouh, ME, Fremes, SE, Holmes, D, Girardi, LN, Nakamura, S, Head, Stuart, Park, SJ, Mack, M, Serruys, PWJC, Ruel, M, Stone, GW, Tam, DY, Vallely, M, Taggart, DP, Gaudino, M, Angiolillo, DJ, Di Franco, A, Capodanno, D, Bakaeen, F, Farkouh, ME, Fremes, SE, Holmes, D, Girardi, LN, Nakamura, S, Head, Stuart, Park, SJ, Mack, M, Serruys, PWJC, Ruel, M, Stone, GW, Tam, DY, Vallely, M, and Taggart, DP
- Published
- 2019
5. Compliance With Guideline-Directed Medical Therapy in Contemporary Coronary Revascularization Trials
- Author
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Pinho-Gomes, AC, Azevedo, L, Ahn, J M, Park, SJ, Hamza, TH, Farkouh, ME, Serruys, PWJC, Milojevic, Milan, Kappetein, Arie-Pieter, Stone, GW, Lamy, A, Fuster, V, Taggart, DP, Pinho-Gomes, AC, Azevedo, L, Ahn, J M, Park, SJ, Hamza, TH, Farkouh, ME, Serruys, PWJC, Milojevic, Milan, Kappetein, Arie-Pieter, Stone, GW, Lamy, A, Fuster, V, and Taggart, DP
- Published
- 2018
6. Processing issues in top-down approaches to quantum computer development in silicon
- Author
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Park, SJ, Park, SJ, Persaud, A, Liddle, JA, Nilsson, J, Bokor, J, Schneider, DH, Rangelow, IW, Schenkel, T, Park, SJ, Park, SJ, Persaud, A, Liddle, JA, Nilsson, J, Bokor, J, Schneider, DH, Rangelow, IW, and Schenkel, T
- Abstract
We describe critical processing issues in our development of single-atom devices for solid-state quantum information processing. Integration of single 31P atoms with control gates and single electron transistor (SET) readout structures is addressed in a silicon-based approach. Results on electrical activation of low-energy (15 keV) P implants in silicon show a strong dose effect on the electrical activation fractions. We identify dopant segregation to the SiO2/Si interface during rapid thermal annealing as a dopant loss mechanism and discuss means to minimize it. Silicon nanowire SET pairs with nanowire width of 10-20 nm are formed by electron-beam lithography in SOI. We present initial results from Coulomb blockade experiments and discuss issues of control gate integration for sub-40 nm gate pitches. © 2004 Elsevier B.V. All rights reserved.
- Published
- 2004
7. Processing issues in top-down approaches to quantum computer development in silicon
- Author
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Park, SJ, Park, SJ, Persaud, A, Liddle, JA, Nilsson, J, Bokor, J, Schneider, DH, Rangelow, IW, Schenkel, T, Park, SJ, Park, SJ, Persaud, A, Liddle, JA, Nilsson, J, Bokor, J, Schneider, DH, Rangelow, IW, and Schenkel, T
- Abstract
We describe critical processing issues in our development of single-atom devices for solid-state quantum information processing. Integration of single 31P atoms with control gates and single electron transistor (SET) readout structures is addressed in a silicon-based approach. Results on electrical activation of low-energy (15 keV) P implants in silicon show a strong dose effect on the electrical activation fractions. We identify dopant segregation to the SiO2/Si interface during rapid thermal annealing as a dopant loss mechanism and discuss means to minimize it. Silicon nanowire SET pairs with nanowire width of 10-20 nm are formed by electron-beam lithography in SOI. We present initial results from Coulomb blockade experiments and discuss issues of control gate integration for sub-40 nm gate pitches. © 2004 Elsevier B.V. All rights reserved.
- Published
- 2004
8. A sector-based dosimetric analysis of dose heterogeneity in high-dose-rate prostate brachytherapy
- Author
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Mesko, S, Mesko, S, Park, SJ, Kishan, AU, Demanes, DJ, Kamrava, M, Mesko, S, Mesko, S, Park, SJ, Kishan, AU, Demanes, DJ, and Kamrava, M
- Abstract
Purpose: High-dose-rate (HDR) prostate brachytherapy delivers a heterogeneous dose distribution throughout the prostate gland. There is however limited information regarding the spatial distribution of this dose heterogeneity. To this end, we analyzed the magnitude and location of intraprostatic dose heterogeneity in HDR prostate brachytherapy. Methods and Materials: Five consecutive prostate cancer patients treated with HDR were analyzed. Based on CT-simulation images, each prostate was divided into three sections (apex, base, and mid-gland). These were further subdivided into eight symmetrical sections to give a total of 24 sections. Dose-volume histograms were analyzed from V100-V200% for these 24 sections comparing the means of individual regions, left vs right, apex vs base vs mid-gland, lateral vs medial, and anterior vs posterior. A separate analysis on dose as a function of individual region volume was also performed. Results: Analyses comparing the 24 regions showed a maximum 62% difference (range, 21.9-83.9%) at V130% and 19.9% (1.9-20.8%) at V200%. Seven regions were significantly decreased and one significantly elevated from V130-V180% when compared with the mean. The means for lateral sections were 1.57-fold higher than medial sections from V110-V200% (. p < 0.0001). The dose at the base was significantly higher than the rest of the gland from V120-V200 (V150, 35.6±16.2% vs 20.9±13.1%, p < 0.0001). Conclusions: There is significant intra-prostatic dose heterogeneity in prostate HDR brachytherapy. This is most notable in the increased dose to base and lateral portions of the gland. Further studies are needed to determine the impact of heterogeneity on clinical outcomes.
- Published
- 2015
9. From whole gland to hemigland to ultra-focal high-dose-rate prostate brachytherapy: A dosimetric analysis
- Author
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Banerjee, R, Banerjee, R, Park, SJ, Anderson, E, Demanes, DJ, Wang, J, Kamrava, M, Banerjee, R, Banerjee, R, Park, SJ, Anderson, E, Demanes, DJ, Wang, J, and Kamrava, M
- Abstract
Purpose: To assess the magnitude of dosimetric reductions of a focal and ultra-focal high-dose-rate (HDR) prostate brachytherapy treatment strategy relative to standard whole gland (WG) treatment. Methods and Materials: HDR brachytherapy plans for five patients treated with WG HDR monotherapy were optimized to assess different treatment strategies. Plans were generated to treat the hemigland (HG), one-third gland (1/3G), and one-sixth gland (1/6G), as well as to assess treating the WG with a boost to one of those sub-volumes (WG+HG, WG+1/3G, WG+1/6G). Dosimetric parameters analyzed included Target D90%, V100%, V150%, Bladder (B), Rectal (R), Urethral (U) D0.1, 1 and 2cc, Urethral V75%, and the V50% to the contralateral HG. Two-tailed t tests were used for comparison of means, and p-values less than 0.05 were considered statistically significant. Results: Target objectives (D90>100% and V100>97%) were met in all cases. Significant organs at risk dose reductions were achieved for all approaches compared with WG plans. 1/6G vs WG plans resulted in the greatest reduction in dose with a mean bladder D2cc 24.7 vs 64.8%, rectal D2cc 32.8 vs 65.3%, urethral D1cc 52.1 vs 103.8%, and V75 14.5 vs 75% (p < 0.05 for all comparisons). Conclusion: Significant dose reductions to organs at risk can be achieved using HDR focal brachytherapy. The magnitude of the reductions achievable with treating progressively smaller sub-volumes suggests the potential to reduce morbidity, but the clinical impact on morbidity and tumor control remain to be investigated.
- Published
- 2015
10. Ureteral stent insertion for gynecologic interstitial high-dose-rate brachytherapy
- Author
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Demanes, DJ, Demanes, DJ, Banerjee, R, Cahan, BL, Lee, SP, Park, SJ, Fallon, JM, Reyes, P, Van, TQ, Steinberg, ML, Kamrava, MR, Demanes, DJ, Demanes, DJ, Banerjee, R, Cahan, BL, Lee, SP, Park, SJ, Fallon, JM, Reyes, P, Van, TQ, Steinberg, ML, and Kamrava, MR
- Abstract
Purpose: To determine the utility of ureteral stents in interstitial gynecological brachytherapy. Methods and Materials: We reviewed 289 patients with cervix cancer treated with high-dose-rate interstitial brachytherapy who did not have pretreatment hydronephrosis to determine the relative incidence of benign ureteral strictures after treatment. We also did comparative dosimetry analysis in five cases of high-dose-rate brachytherapy. Bilateral ureteral stents were placed during the procedure. Three dosimetry plans were created to determine the impact of modifying clinical target volume (CTV) and applying ureteral dose constraints. In Plan 1, the ureters were contoured and excluded from the CTV and 120% dose constraints were applied. In Plan 2, the ureters were contoured and excluded, but no dose constraints were applied to the ureter. In Plan 3, the CTV was created as if the location of the ureters was unknown and then ureteral dose was determined. Results: There were 11 ureteral strictures observed in 255 nonstented cases and 0 ureteral strictures in 34 stented cases. Plan 1 reduced the ureter dose (D0.1cc) by a median 22% (7.0-53.8%) compared with Plan 2 and by a median of 30.9% (12.3-65%). compared with Plan3. Conclusions: Placement of stents and ureteral dose constraints facilitates dosimetry and reduces the dose to ureters. Temporary ureteral stents prevent obstruction during interstitial gynecologic brachytherapy and allows the ureters to be addressed as an organ at risk.
- Published
- 2015
11. New loci and coding variants confer risk for age-related macular degeneration in East Asians.
- Author
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Cheng, C-Y, Yamashiro, K, Chen, LJ, Ahn, J, Huang, L, Cheung, CMG, Miyake, M, Cackett, PD, Yeo, IY, Laude, A, Mathur, R, Pang, J, Sim, KS, Koh, AH, Chen, P, Lee, SY, Wong, D, Chan, CM, Loh, BK, Sun, Y, Davila, S, Nakata, I, Nakanishi, H, Akagi-Kurashige, Y, Gotoh, N, Tsujikawa, A, Matsuda, F, Mori, K, Yoneya, S, Sakurada, Y, Iijima, H, Iida, T, Honda, S, Lai, TYY, Tam, POS, Chen, H, Tang, S, Ding, X, Wen, F, Lu, F, Zhang, X, Shi, Y, Zhao, P, Zhao, B, Sang, J, Gong, B, Dorajoo, R, Yuan, J-M, Koh, W-P, van Dam, RM, Friedlander, Y, Lin, Y, Hibberd, ML, Foo, JN, Wang, N, Wong, CH, Tan, GS, Park, SJ, Bhargava, M, Gopal, L, Naing, T, Liao, J, Ong, PG, Mitchell, P, Zhou, P, Xie, X, Liang, J, Mei, J, Jin, X, Saw, S-M, Ozaki, M, Mizoguchi, T, Kurimoto, Y, Woo, SJ, Chung, H, Yu, H-G, Shin, JY, Park, DH, Kim, IT, Chang, W, Sagong, M, Lee, S-J, Kim, HW, Lee, JE, Li, Y, Liu, J, Teo, YY, Heng, CK, Lim, TH, Yang, S-K, Song, K, Vithana, EN, Aung, T, Bei, JX, Zeng, YX, Tai, ES, Li, XX, Yang, Z, Park, K-H, Pang, CP, Yoshimura, N, Wong, TY, Khor, CC, Cheng, C-Y, Yamashiro, K, Chen, LJ, Ahn, J, Huang, L, Cheung, CMG, Miyake, M, Cackett, PD, Yeo, IY, Laude, A, Mathur, R, Pang, J, Sim, KS, Koh, AH, Chen, P, Lee, SY, Wong, D, Chan, CM, Loh, BK, Sun, Y, Davila, S, Nakata, I, Nakanishi, H, Akagi-Kurashige, Y, Gotoh, N, Tsujikawa, A, Matsuda, F, Mori, K, Yoneya, S, Sakurada, Y, Iijima, H, Iida, T, Honda, S, Lai, TYY, Tam, POS, Chen, H, Tang, S, Ding, X, Wen, F, Lu, F, Zhang, X, Shi, Y, Zhao, P, Zhao, B, Sang, J, Gong, B, Dorajoo, R, Yuan, J-M, Koh, W-P, van Dam, RM, Friedlander, Y, Lin, Y, Hibberd, ML, Foo, JN, Wang, N, Wong, CH, Tan, GS, Park, SJ, Bhargava, M, Gopal, L, Naing, T, Liao, J, Ong, PG, Mitchell, P, Zhou, P, Xie, X, Liang, J, Mei, J, Jin, X, Saw, S-M, Ozaki, M, Mizoguchi, T, Kurimoto, Y, Woo, SJ, Chung, H, Yu, H-G, Shin, JY, Park, DH, Kim, IT, Chang, W, Sagong, M, Lee, S-J, Kim, HW, Lee, JE, Li, Y, Liu, J, Teo, YY, Heng, CK, Lim, TH, Yang, S-K, Song, K, Vithana, EN, Aung, T, Bei, JX, Zeng, YX, Tai, ES, Li, XX, Yang, Z, Park, K-H, Pang, CP, Yoshimura, N, Wong, TY, and Khor, CC
- Abstract
Age-related macular degeneration (AMD) is a major cause of blindness, but presents differently in Europeans and Asians. Here, we perform a genome-wide and exome-wide association study on 2,119 patients with exudative AMD and 5,691 controls, with independent replication in 4,226 patients and 10,289 controls, all of East Asian descent, as part of The Genetics of AMD in Asians (GAMA) Consortium. We find a strong association between CETP Asp442Gly (rs2303790), an East Asian-specific mutation, and increased risk of AMD (odds ratio (OR)=1.70, P=5.60 × 10(-22)). The AMD risk allele (442Gly), known to protect from coronary heart disease, increases HDL cholesterol levels by 0.17 mmol l(-1) (P=5.82 × 10(-21)) in East Asians (n=7,102). We also identify three novel AMD loci: C6orf223 Ala231Ala (OR=0.78, P=6.19 × 10(-18)), SLC44A4 Asp47Val (OR=1.27, P=1.08 × 10(-11)) and FGD6 Gln257Arg (OR=0.87, P=2.85 × 10(-8)). Our findings suggest that some of the genetic loci conferring AMD susceptibility in East Asians are shared with Europeans, yet AMD in East Asians may also have a distinct genetic signature.
- Published
- 2015
12. From whole gland to hemigland to ultra-focal high-dose-rate prostate brachytherapy: A dosimetric analysis
- Author
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Banerjee, R, Banerjee, R, Park, SJ, Anderson, E, Demanes, DJ, Wang, J, Kamrava, M, Banerjee, R, Banerjee, R, Park, SJ, Anderson, E, Demanes, DJ, Wang, J, and Kamrava, M
- Abstract
Purpose: To assess the magnitude of dosimetric reductions of a focal and ultra-focal high-dose-rate (HDR) prostate brachytherapy treatment strategy relative to standard whole gland (WG) treatment. Methods and Materials: HDR brachytherapy plans for five patients treated with WG HDR monotherapy were optimized to assess different treatment strategies. Plans were generated to treat the hemigland (HG), one-third gland (1/3G), and one-sixth gland (1/6G), as well as to assess treating the WG with a boost to one of those sub-volumes (WG+HG, WG+1/3G, WG+1/6G). Dosimetric parameters analyzed included Target D90%, V100%, V150%, Bladder (B), Rectal (R), Urethral (U) D0.1, 1 and 2cc, Urethral V75%, and the V50% to the contralateral HG. Two-tailed t tests were used for comparison of means, and p-values less than 0.05 were considered statistically significant. Results: Target objectives (D90>100% and V100>97%) were met in all cases. Significant organs at risk dose reductions were achieved for all approaches compared with WG plans. 1/6G vs WG plans resulted in the greatest reduction in dose with a mean bladder D2cc 24.7 vs 64.8%, rectal D2cc 32.8 vs 65.3%, urethral D1cc 52.1 vs 103.8%, and V75 14.5 vs 75% (p < 0.05 for all comparisons). Conclusion: Significant dose reductions to organs at risk can be achieved using HDR focal brachytherapy. The magnitude of the reductions achievable with treating progressively smaller sub-volumes suggests the potential to reduce morbidity, but the clinical impact on morbidity and tumor control remain to be investigated.
- Published
- 2015
13. Ureteral stent insertion for gynecologic interstitial high-dose-rate brachytherapy
- Author
-
Demanes, DJ, Demanes, DJ, Banerjee, R, Cahan, BL, Lee, SP, Park, SJ, Fallon, JM, Reyes, P, Van, TQ, Steinberg, ML, Kamrava, MR, Demanes, DJ, Demanes, DJ, Banerjee, R, Cahan, BL, Lee, SP, Park, SJ, Fallon, JM, Reyes, P, Van, TQ, Steinberg, ML, and Kamrava, MR
- Abstract
Purpose: To determine the utility of ureteral stents in interstitial gynecological brachytherapy. Methods and Materials: We reviewed 289 patients with cervix cancer treated with high-dose-rate interstitial brachytherapy who did not have pretreatment hydronephrosis to determine the relative incidence of benign ureteral strictures after treatment. We also did comparative dosimetry analysis in five cases of high-dose-rate brachytherapy. Bilateral ureteral stents were placed during the procedure. Three dosimetry plans were created to determine the impact of modifying clinical target volume (CTV) and applying ureteral dose constraints. In Plan 1, the ureters were contoured and excluded from the CTV and 120% dose constraints were applied. In Plan 2, the ureters were contoured and excluded, but no dose constraints were applied to the ureter. In Plan 3, the CTV was created as if the location of the ureters was unknown and then ureteral dose was determined. Results: There were 11 ureteral strictures observed in 255 nonstented cases and 0 ureteral strictures in 34 stented cases. Plan 1 reduced the ureter dose (D0.1cc) by a median 22% (7.0-53.8%) compared with Plan 2 and by a median of 30.9% (12.3-65%). compared with Plan3. Conclusions: Placement of stents and ureteral dose constraints facilitates dosimetry and reduces the dose to ureters. Temporary ureteral stents prevent obstruction during interstitial gynecologic brachytherapy and allows the ureters to be addressed as an organ at risk.
- Published
- 2015
14. A sector-based dosimetric analysis of dose heterogeneity in high-dose-rate prostate brachytherapy
- Author
-
Mesko, S, Mesko, S, Park, SJ, Kishan, AU, Demanes, DJ, Kamrava, M, Mesko, S, Mesko, S, Park, SJ, Kishan, AU, Demanes, DJ, and Kamrava, M
- Abstract
Purpose: High-dose-rate (HDR) prostate brachytherapy delivers a heterogeneous dose distribution throughout the prostate gland. There is however limited information regarding the spatial distribution of this dose heterogeneity. To this end, we analyzed the magnitude and location of intraprostatic dose heterogeneity in HDR prostate brachytherapy. Methods and Materials: Five consecutive prostate cancer patients treated with HDR were analyzed. Based on CT-simulation images, each prostate was divided into three sections (apex, base, and mid-gland). These were further subdivided into eight symmetrical sections to give a total of 24 sections. Dose-volume histograms were analyzed from V100-V200% for these 24 sections comparing the means of individual regions, left vs right, apex vs base vs mid-gland, lateral vs medial, and anterior vs posterior. A separate analysis on dose as a function of individual region volume was also performed. Results: Analyses comparing the 24 regions showed a maximum 62% difference (range, 21.9-83.9%) at V130% and 19.9% (1.9-20.8%) at V200%. Seven regions were significantly decreased and one significantly elevated from V130-V180% when compared with the mean. The means for lateral sections were 1.57-fold higher than medial sections from V110-V200% (. p < 0.0001). The dose at the base was significantly higher than the rest of the gland from V120-V200 (V150, 35.6±16.2% vs 20.9±13.1%, p < 0.0001). Conclusions: There is significant intra-prostatic dose heterogeneity in prostate HDR brachytherapy. This is most notable in the increased dose to base and lateral portions of the gland. Further studies are needed to determine the impact of heterogeneity on clinical outcomes.
- Published
- 2015
15. First report of the global SYMPLICITY registry on the effect of renal artery denervation in patients with uncontrolled hypertension
- Author
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Böhm, M, Mahfoud, F, Ukena, C, Hoppe, U, Narkiewicz, K, Negoita, M, Ruilope, L, Schlaich, M, Schmieder, R, Whitbourn, R, Williams, B, Zeymer, U, Zirlik, A, Mancia, G, Aguirre, L, Ahn, T, Al Habib, K, Al Jarallah, M, Alimbaev, S, Ammerer, M, Andersson, B, Andersson, J, Andresen, D, Anné, W, Baumgartner, I, Bergmann, M, Berland, J, Bilger, J, Blumenstein, M, Brachmann, J, Branny, M, Brussee, H, Clifford, P, Cornelis, K, Cunnington, M, Cyrne de Carvalho, H, Dandona, S, Danilov, N, Dasgupta, I, Dong Ju, C, Dorsch, M, Drieghe, B, Ebrahim, I, Echeverri, D, Eckert, S, Fajadet, J, Fichtlscherer, S, Fleck, E, Frey, N, Gahnim, D, Galyavich, A, Giannattasio, C, Göing, O, Gomes, M, Goncalves, P, Grossman, E, Grund, M, Gutierrez, E, Gwon, H, Hausberg, M, Hoffmann, E, Ibrahim, R, Jardine, A, Jung, W, Jung, J, Katritsis, D, Kerschbaum, J, Kim, C, Kim, H, Konradi, A, Krasowski, W, Kuznetsov, V, Kwok, O, Kwon, H, Leong, G, Lotan, C, Lurz, P, Luscher, T, Mackinnon, M, Malik, F, Mangos, G, Martinez, C, Mccann, A, Misonis, N, Mölmann, H, Mordovin, V, Mortensen, K, Mueller, O, Muller, O, Münzel, T, Ntsekhe, M, Oliveira, E, Ong, T, Ong, P, Ormiston, J, Oswald, H, Park, S, Park, C, Plehn, A, Pressley, L, Reith, S, Reuter, H, Rosenschein, U, Rottbauer, W, Rump, L, Scheinert, D, Schillinger, S, M, Schultheiss, H, Sechtem, U, Seung, K, Sharif, F, Sharpe, A, Shetty, S, Sievert, H, Soo, J, Teik, L, Stefanadis, C, Stellbrink, C, Sticherling, C, Stoel, M, Strasser, R, Thambar, S, Tonino, P, Udayachalerm, W, Unterseeh, T, Vaclavik, J, von Scheidt, W, Voskuil, M, Wan Ahmad, W, Weber, T, Wedekind, H, Weil, J, Werner, N, Winkens, M, Winter, K, Witkowski, A, Wyffels, E, Yip, T, Zambahari, R, Zeller, T, Zürn, C, MANCIA, GIUSEPPE, Ahn, TH, Ebrahim, IO, GIANNATTASIO, CRISTINA, Gwon, HC, Kim, CJ, Kim, HS, Kwok, OH, Kwon, HM, MacKinnon, M, Malik, FT, McCann, A, Ong, TK, Park, SJ, Park, CG, Rump, LC, Schillinger, Schlaich, Schultheiss, HP, Seung, KB, Soo, JY, Teik, LS, Wan Ahmad, WA, Winter, KD, Zürn, C., Böhm, M, Mahfoud, F, Ukena, C, Hoppe, U, Narkiewicz, K, Negoita, M, Ruilope, L, Schlaich, M, Schmieder, R, Whitbourn, R, Williams, B, Zeymer, U, Zirlik, A, Mancia, G, Aguirre, L, Ahn, T, Al Habib, K, Al Jarallah, M, Alimbaev, S, Ammerer, M, Andersson, B, Andersson, J, Andresen, D, Anné, W, Baumgartner, I, Bergmann, M, Berland, J, Bilger, J, Blumenstein, M, Brachmann, J, Branny, M, Brussee, H, Clifford, P, Cornelis, K, Cunnington, M, Cyrne de Carvalho, H, Dandona, S, Danilov, N, Dasgupta, I, Dong Ju, C, Dorsch, M, Drieghe, B, Ebrahim, I, Echeverri, D, Eckert, S, Fajadet, J, Fichtlscherer, S, Fleck, E, Frey, N, Gahnim, D, Galyavich, A, Giannattasio, C, Göing, O, Gomes, M, Goncalves, P, Grossman, E, Grund, M, Gutierrez, E, Gwon, H, Hausberg, M, Hoffmann, E, Ibrahim, R, Jardine, A, Jung, W, Jung, J, Katritsis, D, Kerschbaum, J, Kim, C, Kim, H, Konradi, A, Krasowski, W, Kuznetsov, V, Kwok, O, Kwon, H, Leong, G, Lotan, C, Lurz, P, Luscher, T, Mackinnon, M, Malik, F, Mangos, G, Martinez, C, Mccann, A, Misonis, N, Mölmann, H, Mordovin, V, Mortensen, K, Mueller, O, Muller, O, Münzel, T, Ntsekhe, M, Oliveira, E, Ong, T, Ong, P, Ormiston, J, Oswald, H, Park, S, Park, C, Plehn, A, Pressley, L, Reith, S, Reuter, H, Rosenschein, U, Rottbauer, W, Rump, L, Scheinert, D, Schillinger, S, M, Schultheiss, H, Sechtem, U, Seung, K, Sharif, F, Sharpe, A, Shetty, S, Sievert, H, Soo, J, Teik, L, Stefanadis, C, Stellbrink, C, Sticherling, C, Stoel, M, Strasser, R, Thambar, S, Tonino, P, Udayachalerm, W, Unterseeh, T, Vaclavik, J, von Scheidt, W, Voskuil, M, Wan Ahmad, W, Weber, T, Wedekind, H, Weil, J, Werner, N, Winkens, M, Winter, K, Witkowski, A, Wyffels, E, Yip, T, Zambahari, R, Zeller, T, Zürn, C, MANCIA, GIUSEPPE, Ahn, TH, Ebrahim, IO, GIANNATTASIO, CRISTINA, Gwon, HC, Kim, CJ, Kim, HS, Kwok, OH, Kwon, HM, MacKinnon, M, Malik, FT, McCann, A, Ong, TK, Park, SJ, Park, CG, Rump, LC, Schillinger, Schlaich, Schultheiss, HP, Seung, KB, Soo, JY, Teik, LS, Wan Ahmad, WA, Winter, KD, and Zürn, C.
- Abstract
This study aimed to assess the safety and effectiveness of renal denervation using the Symplicity system in real-world patients with uncontrolled hypertension (NCT01534299). The Global SYMPLICITY Registry is a prospective, open-label, multicenter registry. Office and 24-hour ambulatory blood pressures (BPs) were measured. Change from baseline to 6 months was analyzed for all patients and for subgroups based on baseline office systolic BP, diabetic status, and renal function; a cohort with severe hypertension (office systolic pressure, ≥160 mm Hg; 24-hour systolic pressure, ≥135 mm Hg; and ≥3 antihypertensive medication classes) was also included. The analysis included protocol-defined safety events. Six-month outcomes for 998 patients, including 323 in the severe hypertension cohort, are reported. Mean baseline office systolic BP was 163.5±24.0 mm Hg for all patients and 179.3±16.5 mm Hg for the severe cohort; the corresponding baseline 24-hour mean systolic BPs were 151.5±17.0 and 159.0±15.6 mm Hg. At 6 months, the changes in office and 24-hour systolic BPs were -11.6±25.3 and -6.6±18.0 mm Hg for all patients (P<0.001 for both) and -20.3±22.8 and -8.9±16.9 mm Hg for those with severe hypertension (P<0.001 for both). Renal denervation was associated with low rates of adverse events. After the procedure through 6 months, there was 1 new renal artery stenosis >70% and 5 cases of hospitalization for a hypertensive emergency. In clinical practice, renal denervation resulted in significant reductions in office and 24-hour BPs with a favorable safety profile. Greater BP-lowering effects occurred in patients with higher baseline pressures. Clinical Trial Registration - URL: www.clinicaltrials.gov. Unique identifier: NCT01534299.
- Published
- 2015
16. Propylene carbonate (PC)-based electrolytes with high coulombic efficiency for lithium-ion batteries
- Author
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Zhao, H, Zhao, H, Park, SJ, Shi, F, Fu, Y, Battaglia, V, Ross, PN, Liu, G, Zhao, H, Zhao, H, Park, SJ, Shi, F, Fu, Y, Battaglia, V, Ross, PN, and Liu, G
- Abstract
A homologous series of propylene carbonate (PC) analog solvents with increasing length of linear alkyl substitutes were synthesized and used as co-solvents with PC for graphite-based lithium-ion half cells. A graphite anode reaches a capacity of around 310 mAh/g in PC and its analog co-solvents, with 99.95 percent Coulombic efficiency, similar to the values obtained with ethylene carbonate-based electrolytes. Solvent interaction with the graphite anode and subsequent decomposition determines the graphite anode performance. Gaseous products from cyclic carbonates with short alkyl chains cause exfoliation of the graphite anode; solvents with longer alkyl chains are able to prevent graphite exfoliation when used as co-solvents with PC. The PC co-solvents compete for solvation of the Li ion with the PC solvent, delaying PC co-intercalation. Reduction products of PC on a graphite surface via a single-electron path form a stable Solid Electrolyte Interphase (SEI), which allows the reversible cycling of graphite. © 2013 The Electrochemical Society.
- Published
- 2014
17. Propylene carbonate (PC)-based electrolytes with high coulombic efficiency for lithium-ion batteries
- Author
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Zhao, H, Zhao, H, Park, SJ, Shi, F, Fu, Y, Battaglia, V, Ross, PN, Liu, G, Zhao, H, Zhao, H, Park, SJ, Shi, F, Fu, Y, Battaglia, V, Ross, PN, and Liu, G
- Abstract
A homologous series of propylene carbonate (PC) analog solvents with increasing length of linear alkyl substitutes were synthesized and used as co-solvents with PC for graphite-based lithium-ion half cells. A graphite anode reaches a capacity of around 310 mAh/g in PC and its analog co-solvents, with 99.95 percent Coulombic efficiency, similar to the values obtained with ethylene carbonate-based electrolytes. Solvent interaction with the graphite anode and subsequent decomposition determines the graphite anode performance. Gaseous products from cyclic carbonates with short alkyl chains cause exfoliation of the graphite anode; solvents with longer alkyl chains are able to prevent graphite exfoliation when used as co-solvents with PC. The PC co-solvents compete for solvation of the Li ion with the PC solvent, delaying PC co-intercalation. Reduction products of PC on a graphite surface via a single-electron path form a stable Solid Electrolyte Interphase (SEI), which allows the reversible cycling of graphite. © 2013 The Electrochemical Society.
- Published
- 2014
18. This title is unavailable for guests, please login to see more information.
- Author
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Park, NM, Kim, TY, Kim, KH, Sung, GY, Kim, BH, Park, SJ, Cho, KS, Shin, JH, Lee, JK, Nastasi, M, Park, NM, Kim, TY, Kim, KH, Sung, GY, Kim, BH, Park, SJ, Cho, KS, Shin, JH, Lee, JK, and Nastasi, M
- Published
- 2005
19. Effect of rapid thermal annealing on Al doped n-ZnO films grown by RF-magnetron sputtering
- Author
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Kim, KK, Tampo, H, Song, JO, Seong, TY, Park, SJ, Lee, JM, Kim, SW, Fujita, S, Niki, S, Kim, KK, Tampo, H, Song, JO, Seong, TY, Park, SJ, Lee, JM, Kim, SW, Fujita, S, and Niki, S
- Published
- 2005
20. High electron concentration and mobility in Al-doped n-ZnO epilayer achieved via dopant activation using rapid-thermal annealing
- Author
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Kim, KK, Niki, S, Oh, JY, Song, JO, Seong, TY, Park, SJ, Fujita, S, Kim, SW, Kim, KK, Niki, S, Oh, JY, Song, JO, Seong, TY, Park, SJ, Fujita, S, and Kim, SW
- Published
- 2005
21. High electron concentration and mobility in Al-doped n-ZnO epilayer achieved via dopant activation using rapid-thermal annealing
- Author
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Kim, KK, Niki, S, Oh, JY, Song, JO, Seong, TY, Park, SJ, Fujita, S, Kim, SW, Kim, KK, Niki, S, Oh, JY, Song, JO, Seong, TY, Park, SJ, Fujita, S, and Kim, SW
- Published
- 2005
22. Effect of rapid thermal annealing on Al doped n-ZnO films grown by RF-magnetron sputtering
- Author
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20135536, Kim, KK, Tampo, H, Song, JO, Seong, TY, Park, SJ, Lee, JM, Kim, SW, Fujita, S, Niki, S, 20135536, Kim, KK, Tampo, H, Song, JO, Seong, TY, Park, SJ, Lee, JM, Kim, SW, Fujita, S, and Niki, S
- Published
- 2005
23. Readiness of the ATLAS liquid argon calorimeter for LHC collisions
- Author
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ATLAS Collaboration, Aad, G, Abbott, B, Abdallah, J, Abdelalim, AA, Abdesselam, A, Abdinov, O, Abi, B, Abolins, M, Abramowicz, H, Abreu, H, Acharya, BS, Adams, DL, Addy, TN, Adelman, J, Adorisio, C, Adragna, P, Adye, T, Aefsky, S, Aguilar-Saavedra, JA, Aharrouche, M, Ahlen, SP, Ahles, F, Ahmad, A, Ahmed, H, Ahsan, M, Aielli, G, Akdogan, T, Åkesson, TPA, Akimoto, G, Akimov, AV, Aktas, A, Alam, MS, Alam, MA, Albert, J, Albrand, S, Aleksa, M, Aleksandrov, IN, Alessandria, F, Alexa, C, Alexander, G, Alexandre, G, Alexopoulos, T, Alhroob, M, Aliev, M, Alimonti, G, Alison, J, Aliyev, M, Allport, PP, Allwood-Spiers, SE, Almond, J, Aloisio, A, Alon, R, Alonso, A, Alviggi, MG, Amako, K, Amelung, C, Ammosov, VV, Amorim, A, Amorós, G, Amram, N, Anastopoulos, C, Andeen, T, Anders, CF, Anderson, KJ, Andreazza, A, Andrei, V, Anduaga, XS, Angerami, A, Anghinolfi, F, Anjos, N, Antonaki, A, Antonelli, M, Antonelli, S, Antunovic, B, Anulli, F, Aoun, S, Arabidze, G, Aracena, I, Arai, Y, Arce, ATH, Archambault, JP, Arfaoui, S, Arguin, J, Argyropoulos, T, Arik, E, Arik, M, Armbruster, AJ, Arnaez, O, Arnault, C, Artamonov, A, Arutinov, D, Asai, M, Asai, S, Asfandiyarov, R, Ask, S, Åsman, B, Asner, D, Asquith, L, Assamagan, K, Astbury, A, Astvatsatourov, A, Atoian, G, Auerbach, B, Auge, E, Augsten, K, Aurousseau, M, Austin, N, Avolio, G, Avramidou, R, Axen, D, Ay, C, Azuelos, G, Azuma, Y, Baak, MA, Baccaglioni, G, Bacci, C, Bach, A, Bachacou, H, Bachas, K, Backes, M, Badescu, E, Bagnaia, P, Bai, Y, Bailey, DC, Bain, T, Baines, JT, Baker, OK, Baker, MD, Dos Santos Pedrosa, FB, Banas, E, Banerjee, P, Banerjee, S, Banfi, D, Bangert, A, Bansal, V, Baranov, SP, Baranov, S, Barashkou, A, Barber, T, Barberio, EL, Barberis, D, Barbero, M, Bardin, DY, Barillari, T, Barisonzi, M, Barklow, T, Barlow, N, Barnett, BM, Barnett, RM, Baron, S, Baroncelli, A, Barr, AJ, Barreiro, F, Barreiro Guimarães da Costa, J, Barrillon, P, Barros, N, Bartoldus, R, Bartsch, D, Bastos, J, Bates, RL, Bathe, S, Batkova, L, Batley, JR, Battaglia, A, Battistin, M, Bauer, F, Bawa, HS, Bazalova, M, Beare, B, Beau, T, Beauchemin, PH, Beccherle, R, Becerici, N, Bechtle, P, Beck, GA, Beck, HP, Beckingham, M, Becks, KH, Bedajanek, I, Beddall, AJ, Beddall, A, Bednár, P, Bednyakov, VA, Bee, C, Begel, M, Behar Harpaz, S, Behera, PK, Beimforde, M, Belanger-Champagne, C, Bell, PJ, Bell, WH, Bella, G, Bellagamba, L, Bellina, F, Bellomo, M, Belloni, A, Belotskiy, K, Beltramello, O, Ben Ami, S, Benary, O, Benchekroun, D, Bendel, M, Benedict, BH, Benekos, N, Benhammou, Y, Benincasa, GP, Benjamin, DP, Benoit, M, Bensinger, JR, Benslama, K, Bentvelsen, S, Beretta, M, Berge, D, Bergeaas Kuutmann, E, Berger, N, Berghaus, F, Berglund, E, Beringer, J, Bernardet, K, Bernat, P, Bernhard, R, Bernius, C, Berry, T, Bertin, A, Besson, N, Bethke, S, Bianchi, RM, Bianco, M, Biebel, O, Biesiada, J, Biglietti, M, Bilokon, H, Bindi, M, Binet, S, Bingul, A, Bini, C, Biscarat, C, Bitenc, U, Black, KM, Blair, RE, Blanchard, J, Blanchot, G, Blocker, C, Blocki, J, Blondel, A, Blum, W, Blumenschein, U, Bobbink, GJ, Bocci, A, Boehler, M, Boek, J, Boelaert, N, Böser, S, Bogaerts, JA, Bogouch, A, Bohm, C, Bohm, J, Boisvert, V, Bold, T, Boldea, V, Boldyrev, A, Bondarenko, VG, Bondioli, M, Boonekamp, M, Booth, JRA, Bordoni, S, Borer, C, Borisov, A, Borissov, G, Borjanovic, I, Borroni, S, Bos, K, Boscherini, D, Bosman, M, Bosteels, M, Boterenbrood, H, Bouchami, J, Boudreau, J, Bouhova-Thacker, EV, Boulahouache, C, Bourdarios, C, Boyd, J, Boyko, IR, Bozovic-Jelisavcic, I, Bracinik, J, Braem, A, Branchini, P, Brandenburg, GW, Brandt, A, Brandt, G, Brandt, O, Bratzler, U, Brau, B, Brau, JE, Braun, HM, Brelier, B, Bremer, J, Brenner, R, Bressler, S, Breton, D, Brett, ND, Britton, D, Brochu, FM, Brock, I, Brock, R, Brodbeck, TJ, Brodet, E, Broggi, F, Bromberg, C, Brooijmans, G, Brooks, WK, Brown, G, Brubaker, E, Bruckman de Renstrom, PA, Bruncko, D, Bruneliere, R, Brunet, S, Bruni, A, Bruni, G, Bruschi, M, Buanes, T, Bucci, F, Buchanan, J, Buchholz, P, Buckley, AG, Budagov, IA, Budick, B, Büscher, V, Bugge, L, Bulekov, O, Bunse, M, Buran, T, Burckhart, H, Burdin, S, Burgess, T, Burke, S, Busato, E, Bussey, P, Buszello, CP, Butin, F, Butler, B, Butler, JM, Buttar, CM, Butterworth, JM, Byatt, T, Caballero, J, Cabrera Urbán, S, Caforio, D, Cakir, O, Calafiura, P, Calderini, G, Calfayan, P, Calkins, R, Caloba, LP, Caloi, R, Calvet, D, Camarri, P, Cambiaghi, M, Cameron, D, Campabadal Segura, F, Campana, S, Campanelli, M, Canale, V, Canelli, F, Canepa, A, Cantero, J, Capasso, L, Capeans Garrido, MDM, Caprini, I, Caprini, M, Capua, M, Caputo, R, Caracinha, D, Caramarcu, C, Cardarelli, R, Carli, T, Carlino, G, Carminati, L, Caron, B, Caron, S, Carrillo Montoya, GD, Carron Montero, S, Carter, AA, Carter, JR, Carvalho, J, Casadei, D, Casado, MP, Cascella, M, Caso, C, Castaneda Hernadez, AM, Castaneda-Miranda, E, Castillo Gimenez, V, Castro, N, Cataldi, G, Catinaccio, A, Catmore, JR, Cattai, A, Cattani, G, Caughron, S, Cauz, D, Cavalleri, P, Cavalli, D, Cavalli-Sforza, M, Cavasinni, V, Ceradini, F, Cerqueira, AS, Cerri, A, Cerrito, L, Cerutti, F, Cetin, SA, Cevenini, F, Chafaq, A, Chakraborty, D, Chan, K, Chapman, JD, Chapman, JW, Chareyre, E, Charlton, DG, Chavda, V, Cheatham, S, Chekanov, S, Chekulaev, SV, Chelkov, GA, Chen, H, Chen, S, Chen, T, Chen, X, Cheng, S, Cheplakov, A, Chepurnov, VF, Cherkaoui El Moursli, R, Tcherniatine, V, Chesneanu, D, Cheu, E, Cheung, SL, Chevalier, L, Chevallier, F, Chiarella, V, Chiefari, G, Chikovani, L, Childers, JT, Chilingarov, A, Chiodini, G, Chizhov, M, Choudalakis, G, Chouridou, S, Chren, D, Christidi, IA, Christov, A, Chromek-Burckhart, D, Chu, ML, Chudoba, J, Ciapetti, G, Ciftci, AK, Ciftci, R, Cinca, D, Cindro, V, Ciobotaru, MD, Ciocca, C, Ciocio, A, Cirilli, M, Citterio, M, Clark, A, Cleland, W, Clemens, JC, Clement, B, Clement, C, Clements, D, Coadou, Y, Cobal, M, Coccaro, A, Cochran, J, Coelli, S, Coggeshall, J, Cogneras, E, Cojocaru, CD, Colas, J, Cole, B, Colijn, AP, Collard, C, Collins, NJ, Collins-Tooth, C, Collot, J, Colon, G, Coluccia, R, Conde Muiño, P, Coniavitis, E, Consonni, M, Constantinescu, S, Conta, C, Conventi, F, Cook, J, Cooke, M, Cooper, BD, Cooper-Sarkar, AM, Cooper-Smith, NJ, Copic, K, Cornelissen, T, Corradi, M, Corriveau, F, Corso-Radu, A, Cortes-Gonzalez, A, Cortiana, G, Costa, G, Costa, MJ, Costanzo, D, Costin, T, Côté, D, Coura Torres, R, Courneyea, L, Cowan, G, Cowden, C, Cox, BE, Cranmer, K, Cranshaw, J, Cristinziani, M, Crosetti, G, Crupi, R, Crépé-Renaudin, S, Cuenca Almenar, C, Cuhadar Donszelmann, T, Curatolo, M, Curtis, CJ, Cwetanski, P, Czyczula, Z, D¿Auria, S, D¿Onofrio, M, D¿Orazio, A, Da Silva, PVM, Da Via, C, Dabrowski, W, Dai, T, Dallapiccola, C, Dallison, SJ, Daly, CH, Dam, M, Danielsson, HO, Dannheim, D, Dao, V, Darbo, G, Darlea, GL, Davey, W, Davidek, T, Davidson, N, Davidson, R, Davison, AR, Dawson, I, Dawson, JW, Daya, RK, De, K, Asmundis, R, Castro, S, Castro Faria Salgado, 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