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1. Colorectal neoplastic emergencies in immunocompromised patients: preliminary result from the Web-based International Register of Emergency Surgery and Trauma (WIRES-T trial)

Author

Coccolini, F, Mazzoni, A, Cremonini, C, Cobuccio, L, Pucciarelli, M, Vetere, G, Borelli, B, Strambi, S, Musetti, S, Miccoli, M, Cremolini, C, Salvetti, F, Fugazzola, P, Ceresoli, M, Elisa, N, Litvin, A, Lostoridis, E, Ahmed, A, Manatakis, D, Negoi, I, Ioannidis, O, Uzunoglu, M, Tochie, J, Cillara, N, Tomadze, G, Bala, M, Isik, A, Fonseca, V, Bellanova, G, Ghannam, W, Yalkin, O, Garcia, F, Altintoprak, F, Hadzhiev, D, Chirica, M, Zese, M, Balalis, D, Cui, Y, Luppi, D, Romeo, L, Muratore, A, Lunghi, E, Yovtchev, Y, Nikolopoulos, I, Omerovic, M, Zizzo, M, Ugoletti, L, Costa, G, Scalzone, R, Perrone, S, Occhionorelli, S, Nardi, M, Gubbiotti, F, Catena, F, Muhtaroglu, A, Scaramuzzo, R, Corte, H, Yanez, C, Zakaria, A, Seretis, C, Gelmini, R, Pappalardo, V, Paratore, F, Sydorchuk, R, Mulita, F, Kara, Y, Toma, E, Vailas, M, Sotiropoulou, M, Benedetti, F, Elbahnasawy, M, Sibilla, M, Martines, G, Goksoy, B, Parini, D, Zaghi, C, Podda, M, Osipov, A, Brisinda, G, Gambino, G, Akhmeteli, L, Doklestic, K, Loncar, Z, Micic, D, Lesevic, I, D'Agostino, F, Garzali, I, Caicedo, Y, Marcela, L, Marin, P, Perivoliotis, K, Ntentas, I, Kuptsov, A, Dimitrov, E, Chowdhury, S, Patel, T, Sartelli, M, Tartaglia, D, Chiarugi, M, Coccolini F., Mazzoni A., Cremonini C., Cobuccio L., Pucciarelli M., Vetere G., Borelli B., Strambi S., Musetti S., Miccoli M., Cremolini C., Salvetti F., Fugazzola P., Ceresoli M., Elisa N. G., Litvin A., Lostoridis E., Ahmed A. Y. Y. M., Manatakis D., Negoi I., Ioannidis O., Uzunoglu M. Y., Tochie J. N., Cillara N., Tomadze G., Bala M., Isik A., Fonseca V. C., Bellanova G., Ghannam W., Yalkin O., Garcia F. H., Altintoprak F., Hadzhiev D., Chirica M., Zese M., Balalis D., Cui Y., Luppi D., Romeo L., Muratore A., Lunghi E. G., Yovtchev Y., Nikolopoulos I., Omerovic M., Zizzo M., Ugoletti L., Costa G., Scalzone R., Perrone S., Occhionorelli S., Nardi M., Gubbiotti F., Catena F., Muhtaroglu A., Scaramuzzo R., Corte H., Yanez C., Zakaria A. D., Seretis C., Gelmini R., Pappalardo V., Paratore F., Sydorchuk R., Mulita F., Kara Y., Toma E. A., Vailas M., Sotiropoulou M., Benedetti F., Elbahnasawy M., Sibilla M. G., Martines G., Goksoy B., Parini D., Zaghi C., Podda M., Osipov A., Brisinda G., Gambino G., Akhmeteli L., Doklestic K., Loncar Z., Micic D., Lesevic I., D'Agostino F., Garzali I. U., Caicedo Y., Marcela L., Marin P. A. G., Perivoliotis K., Ntentas I., Kuptsov A., Dimitrov E., Chowdhury S., Patel T., Sartelli M., Tartaglia D., Chiarugi M., Coccolini, F, Mazzoni, A, Cremonini, C, Cobuccio, L, Pucciarelli, M, Vetere, G, Borelli, B, Strambi, S, Musetti, S, Miccoli, M, Cremolini, C, Salvetti, F, Fugazzola, P, Ceresoli, M, Elisa, N, Litvin, A, Lostoridis, E, Ahmed, A, Manatakis, D, Negoi, I, Ioannidis, O, Uzunoglu, M, Tochie, J, Cillara, N, Tomadze, G, Bala, M, Isik, A, Fonseca, V, Bellanova, G, Ghannam, W, Yalkin, O, Garcia, F, Altintoprak, F, Hadzhiev, D, Chirica, M, Zese, M, Balalis, D, Cui, Y, Luppi, D, Romeo, L, Muratore, A, Lunghi, E, Yovtchev, Y, Nikolopoulos, I, Omerovic, M, Zizzo, M, Ugoletti, L, Costa, G, Scalzone, R, Perrone, S, Occhionorelli, S, Nardi, M, Gubbiotti, F, Catena, F, Muhtaroglu, A, Scaramuzzo, R, Corte, H, Yanez, C, Zakaria, A, Seretis, C, Gelmini, R, Pappalardo, V, Paratore, F, Sydorchuk, R, Mulita, F, Kara, Y, Toma, E, Vailas, M, Sotiropoulou, M, Benedetti, F, Elbahnasawy, M, Sibilla, M, Martines, G, Goksoy, B, Parini, D, Zaghi, C, Podda, M, Osipov, A, Brisinda, G, Gambino, G, Akhmeteli, L, Doklestic, K, Loncar, Z, Micic, D, Lesevic, I, D'Agostino, F, Garzali, I, Caicedo, Y, Marcela, L, Marin, P, Perivoliotis, K, Ntentas, I, Kuptsov, A, Dimitrov, E, Chowdhury, S, Patel, T, Sartelli, M, Tartaglia, D, Chiarugi, M, Coccolini F., Mazzoni A., Cremonini C., Cobuccio L., Pucciarelli M., Vetere G., Borelli B., Strambi S., Musetti S., Miccoli M., Cremolini C., Salvetti F., Fugazzola P., Ceresoli M., Elisa N. G., Litvin A., Lostoridis E., Ahmed A. Y. Y. M., Manatakis D., Negoi I., Ioannidis O., Uzunoglu M. Y., Tochie J. N., Cillara N., Tomadze G., Bala M., Isik A., Fonseca V. C., Bellanova G., Ghannam W., Yalkin O., Garcia F. H., Altintoprak F., Hadzhiev D., Chirica M., Zese M., Balalis D., Cui Y., Luppi D., Romeo L., Muratore A., Lunghi E. G., Yovtchev Y., Nikolopoulos I., Omerovic M., Zizzo M., Ugoletti L., Costa G., Scalzone R., Perrone S., Occhionorelli S., Nardi M., Gubbiotti F., Catena F., Muhtaroglu A., Scaramuzzo R., Corte H., Yanez C., Zakaria A. D., Seretis C., Gelmini R., Pappalardo V., Paratore F., Sydorchuk R., Mulita F., Kara Y., Toma E. A., Vailas M., Sotiropoulou M., Benedetti F., Elbahnasawy M., Sibilla M. G., Martines G., Goksoy B., Parini D., Zaghi C., Podda M., Osipov A., Brisinda G., Gambino G., Akhmeteli L., Doklestic K., Loncar Z., Micic D., Lesevic I., D'Agostino F., Garzali I. U., Caicedo Y., Marcela L., Marin P. A. G., Perivoliotis K., Ntentas I., Kuptsov A., Dimitrov E., Chowdhury S., Patel T., Sartelli M., Tartaglia D., and Chiarugi M.

Abstract

Association of advanced age, neoplastic disease and immunocompromission (IC) may lead to surgical emergencies. Few data exist about this topic. Present study reports the preliminary data from the WIRES-T trial about patients managed for colorectal neoplastic emergencies in immunocompromised patients. The required data were taken from a prospective observational international register. The study was approved by the Ethical Committee with approval n. 17575; ClinicalTrials.gov Identifier: NCT03643718. 839 patients were collected; 753 (80.7%) with mild–moderate IC and 86 (10.3%) with severe. Median age was 71.9 years and 73 years, respectively, in the two groups. The causes of mild–moderate IC were reported such malignancy (753–100%), diabetes (103–13.7%), malnutrition (26–3.5%) and uremia (1–0.1%), while severe IC causes were steroids treatment (14–16.3%); neutropenia (7–8.1%), malignancy on chemotherapy (71–82.6%). Preoperative risk classification were reported as follow: mild–moderate: ASA 1–14 (1.9%); ASA 2–202 (26.8%); ASA 3–341 (45.3%); ASA 4–84 (11.2%); ASA 5–7 (0.9%); severe group: ASA 1-1 patient (1.2%); ASA 2–16 patients (18.6%); ASA 3–41 patients (47.7%); ASA 4–19 patients (22.1%); ASA 5–3 patients (3.5%); lastly, ASA score was unavailable for 105 cases (13.9%) in mild–moderate group and in 6 cases (6.9%) in severe group. All the patients enrolled underwent urgent/emergency surgery Damage control approach with open abdomen was adopted in 18 patients. Mortality was 5.1% and 12.8%, respectively, in mild–moderate and severe groups. Long-term survival data: in mild–moderate disease-free survival (median, IQR) is 28 (10–91) and in severe IC, it is 21 (10–94). Overall survival (median, IQR) is 44 (18–99) and 26 (20–90) in mild–moderate and severe, respectively; the same is for post-progression survival (median, IQR) 29 (16–81) and 28, respectively. Univariate and multivariate analyses showed as the only factor influencing mortality in mild–moderate and severe IC is

Published
2023

2. Acute diverticulitis in immunocompromised patients: evidence from an international multicenter observational registry (Web-based International Register of Emergency Surgery and Trauma, Wires-T)

Author

Tartaglia, D, Cremonini, C, Annunziata, E, Catena, F, Sartelli, M, Kirkpatrick, A, Musetti, S, Strambi, S, Chiarugi, M, Coccolini, F, Salvetti, F, Fugazzola, P, Ceresoli, M, Benedetti, F, Elisa, N, Litvin, A, Lostoridis, E, Ahmed, A, Manatakis, D, Negoi, I, Ioannidis, O, Uzunoglu, M, Tochie, J, Cillara, N, Tomadze, G, Bala, M, Isik, A, Fonseca, V, Bellanova, G, Ghannam, W, Yalkin, O, Garcia, F, Altintoprak, F, Hadzhiev, D, Chirica, M, Zese, M, Balalis, D, Cui, Y, Luppi, D, Romeo, L, Muratore, A, Lunghi, E, Yovtchev, Y, Dimitrov, E, Nikolopoulos, I, Omerovic, M, Zizzo, M, Ugoletti, L, Costa, G, Scalzone, R, Perrone, S, Occhionorelli, S, Nardi, M, Gubbiotti, F, Muhtaroglu, A, Scaramuzzo, R, Corte, H, Yanez, C, Zakaria, A, Seretis, C, Gelmini, R, Pappalardo, V, Paratore, F, Sydorchuk, R, Mulita, F, Kara, Y, Toma, E, Vailas, M, Sotiropoulou, M, Elbahnasawy, M, Sibilla, M, Martines, G, Goksoy, B, Parini, D, Zaghi, C, Podda, M, Osipov, A, Brisinda, G, Gambino, G, Doklestic, L, Loncar, Z, Micic, D, Lesevic, I, D'Agostino, F, Garzali, I, Caicedo, Y, Marcela, L, Marin, P, Perivoliotis, K, Ntentas, I, Kuptsov, A, Chowdhury, S, Patel, T, Tartaglia D., Cremonini C., Annunziata E., Catena F., Sartelli M., Kirkpatrick A. W., Musetti S., Strambi S., Chiarugi M., Coccolini F., Salvetti F., Fugazzola P., Ceresoli M., Benedetti F., Elisa N. G., Litvin A., Lostoridis E., Ahmed A. Y. Y. M., Manatakis D., Negoi I., Ioannidis O., Uzunoglu M. Y., Tochie J. N., Cillara N., Tomadze G., Bala M., Isik A., Fonseca V. C., Bellanova G., Ghannam W., Yalkin O., Garcia F. H., Altintoprak F., Hadzhiev D., Chirica M., Zese M., Balalis D., Cui Y., Luppi D., Romeo L., Muratore A., Lunghi E. G., Yovtchev Y., Dimitrov E., Nikolopoulos I., Omerovic M., Zizzo M., Ugoletti L., Costa G., Scalzone R., Perrone S., Occhionorelli S., Nardi M., Gubbiotti F., Muhtaroglu A., Scaramuzzo R., Corte H., Yanez C., Zakaria A. D., Seretis C., Gelmini R., Pappalardo V., Paratore F., Sydorchuk R., Mulita F., Kara Y., Toma E. A., Vailas M., Sotiropoulou M., Elbahnasawy M., Sibilla M. G., Martines G., Goksoy B., Parini D., Zaghi C., Podda M., Osipov A., Brisinda G., Gambino G., Doklestic L. A. K., Loncar Z., Micic D., Lesevic I., D'Agostino F., Garzali I. U., Caicedo Y., Marcela L., Marin P. A. G., Perivoliotis K., Ntentas I., Kuptsov A., Chowdhury S., Patel T., Tartaglia, D, Cremonini, C, Annunziata, E, Catena, F, Sartelli, M, Kirkpatrick, A, Musetti, S, Strambi, S, Chiarugi, M, Coccolini, F, Salvetti, F, Fugazzola, P, Ceresoli, M, Benedetti, F, Elisa, N, Litvin, A, Lostoridis, E, Ahmed, A, Manatakis, D, Negoi, I, Ioannidis, O, Uzunoglu, M, Tochie, J, Cillara, N, Tomadze, G, Bala, M, Isik, A, Fonseca, V, Bellanova, G, Ghannam, W, Yalkin, O, Garcia, F, Altintoprak, F, Hadzhiev, D, Chirica, M, Zese, M, Balalis, D, Cui, Y, Luppi, D, Romeo, L, Muratore, A, Lunghi, E, Yovtchev, Y, Dimitrov, E, Nikolopoulos, I, Omerovic, M, Zizzo, M, Ugoletti, L, Costa, G, Scalzone, R, Perrone, S, Occhionorelli, S, Nardi, M, Gubbiotti, F, Muhtaroglu, A, Scaramuzzo, R, Corte, H, Yanez, C, Zakaria, A, Seretis, C, Gelmini, R, Pappalardo, V, Paratore, F, Sydorchuk, R, Mulita, F, Kara, Y, Toma, E, Vailas, M, Sotiropoulou, M, Elbahnasawy, M, Sibilla, M, Martines, G, Goksoy, B, Parini, D, Zaghi, C, Podda, M, Osipov, A, Brisinda, G, Gambino, G, Doklestic, L, Loncar, Z, Micic, D, Lesevic, I, D'Agostino, F, Garzali, I, Caicedo, Y, Marcela, L, Marin, P, Perivoliotis, K, Ntentas, I, Kuptsov, A, Chowdhury, S, Patel, T, Tartaglia D., Cremonini C., Annunziata E., Catena F., Sartelli M., Kirkpatrick A. W., Musetti S., Strambi S., Chiarugi M., Coccolini F., Salvetti F., Fugazzola P., Ceresoli M., Benedetti F., Elisa N. G., Litvin A., Lostoridis E., Ahmed A. Y. Y. M., Manatakis D., Negoi I., Ioannidis O., Uzunoglu M. Y., Tochie J. N., Cillara N., Tomadze G., Bala M., Isik A., Fonseca V. C., Bellanova G., Ghannam W., Yalkin O., Garcia F. H., Altintoprak F., Hadzhiev D., Chirica M., Zese M., Balalis D., Cui Y., Luppi D., Romeo L., Muratore A., Lunghi E. G., Yovtchev Y., Dimitrov E., Nikolopoulos I., Omerovic M., Zizzo M., Ugoletti L., Costa G., Scalzone R., Perrone S., Occhionorelli S., Nardi M., Gubbiotti F., Muhtaroglu A., Scaramuzzo R., Corte H., Yanez C., Zakaria A. D., Seretis C., Gelmini R., Pappalardo V., Paratore F., Sydorchuk R., Mulita F., Kara Y., Toma E. A., Vailas M., Sotiropoulou M., Elbahnasawy M., Sibilla M. G., Martines G., Goksoy B., Parini D., Zaghi C., Podda M., Osipov A., Brisinda G., Gambino G., Doklestic L. A. K., Loncar Z., Micic D., Lesevic I., D'Agostino F., Garzali I. U., Caicedo Y., Marcela L., Marin P. A. G., Perivoliotis K., Ntentas I., Kuptsov A., Chowdhury S., and Patel T.

Abstract

Background: Immunocompromised patients with acute diverticulitis are at increased risk of morbidity and mortality. The aim of this study was to compare clinical presentations, types of treatment, and outcomes between immunocompromised and immunocompetent patients with acute diverticulitis. Methods: We compared the data of patients with acute diverticulitis extracted from the Web-based International Registry of Emergency Surgery and Trauma (WIRES-T) from January 2018 to December 2021. First, two groups were identified: medical therapy (A) and surgical therapy (B). Each group was divided into three subgroups: nonimmunocompromised (grade 0), mildly to moderately (grade 1), and severely immunocompromised (grade 2). Results: Data from 482 patients were analyzed—229 patients (47.5%) [M:F = 1:1; median age: 60 (24–95) years] in group A and 253 patients (52.5%) [M:F = 1:1; median age: 71 (26–94) years] in group B. There was a significant difference between the two groups in grade distribution: 69.9% versus 38.3% for grade 0, 26.6% versus 51% for grade 1, and 3.5% versus 10.7% for grade 2 (p < 0.00001). In group A, severe sepsis (p = 0.027) was more common in higher grades of immunodeficiency. Patients with grade 2 needed longer hospitalization (p = 0.005). In group B, a similar condition was found in terms of severe sepsis (p = 0.002), quick Sequential Organ Failure Assessment score > 2 (p = 0.0002), and Mannheim Peritonitis Index (p = 0.010). A Hartmann’s procedure is mainly performed in grades 1–2 (p < 0.0001). Major complications increased significantly after a Hartmann’s procedure (p = 0.047). Mortality was higher in the immunocompromised patients (p = 0.002). Conclusions: Immunocompromised patients with acute diverticulitis present with a more severe clinical picture. When surgery is required, immunocompromised patients mainly undergo a Hartmann’s procedure. Postoperative morbidity and mortality are, however, higher in immunocompromised patients, who also requ

Published
2023

3. Restructuring surgical training after COVID-19 pandemic: A nationwide survey on the Italian scenario on behalf of the Italian polyspecialistic young surgeons society (SPIGC)

Author

Gaetano, G., Guaitoli, E., Barra, F., Picciariello, A., Pasculli, A., Coppola, A., Pertile, D., Meniconi, R. L., Berton, F., Conti, L., Formisano, G., Iossa, A., Maruccia, M., Mazzari, Mario Attilio, Oragano, L., Ratti, F., Serenari, M., Settembrini, A., Sirignano, P., Soriero, D., Vallicelli, C., Vizzielli, Giuseppe, Dimonte, R., Cianci, Stefano, Giovenzana, M., Palmieri, G., Pasqui, E., Petrillo, Marco, Portigliotti, L., Sambucci, D., Sena, G., Sparavigna, M., Bettini, G., Fanello, G., Mendogni, P., Monteleone, L., Ardo, N. P., Tomaiuolo, P., Tomasicchio, G., Paradiso, N., Dibra, R., Trigiante, G., Dezi, A., Carbone, Luigi, Negrello, S., Di Bartolomeo, M., Patini, Romeo, Marcuzzo, A. V., Campione, A., Comacchio, G., Murana, G., Antonio, M., Manitto, M., Galzerano, G., Di Marco, Carmine, Velluti, F., Berardi, Giulia, Romboli, A., Perelli, F., Weindelmejer, J., Tamburrino, D., Calarco, Alessandro, Losco, L., Nacchiero, E., Elia, R., Torto, F. L., Vicenti, G., Pappalardo, V., Pisani, D., Palmisano, Gerardo, Brascia, D., Troisi, L., Renzi, F., Melandro, F., Pecere, Silvia, Gazia, C., Di Franco, G., Romano, G., Bolletta, A., Botteri, E., Di Meo, G., Chiappetta, S., Sgaramella, I., Pennestri, F., Girardi, A., Mariniello, D., Marcasciano, M., Telegrafo, M., Fracomeni, S., De Paoli, F., Mazzari A. (ORCID:0000-0002-7301-6834), Vizzielli G., Cianci S., Petrillo M., Carbone L., Patini R. (ORCID:0000-0001-7358-8763), Di Marco C., Berardi G., Calarco A., Palmisano G., Pecere S., Gaetano, G., Guaitoli, E., Barra, F., Picciariello, A., Pasculli, A., Coppola, A., Pertile, D., Meniconi, R. L., Berton, F., Conti, L., Formisano, G., Iossa, A., Maruccia, M., Mazzari, Mario Attilio, Oragano, L., Ratti, F., Serenari, M., Settembrini, A., Sirignano, P., Soriero, D., Vallicelli, C., Vizzielli, Giuseppe, Dimonte, R., Cianci, Stefano, Giovenzana, M., Palmieri, G., Pasqui, E., Petrillo, Marco, Portigliotti, L., Sambucci, D., Sena, G., Sparavigna, M., Bettini, G., Fanello, G., Mendogni, P., Monteleone, L., Ardo, N. P., Tomaiuolo, P., Tomasicchio, G., Paradiso, N., Dibra, R., Trigiante, G., Dezi, A., Carbone, Luigi, Negrello, S., Di Bartolomeo, M., Patini, Romeo, Marcuzzo, A. V., Campione, A., Comacchio, G., Murana, G., Antonio, M., Manitto, M., Galzerano, G., Di Marco, Carmine, Velluti, F., Berardi, Giulia, Romboli, A., Perelli, F., Weindelmejer, J., Tamburrino, D., Calarco, Alessandro, Losco, L., Nacchiero, E., Elia, R., Torto, F. L., Vicenti, G., Pappalardo, V., Pisani, D., Palmisano, Gerardo, Brascia, D., Troisi, L., Renzi, F., Melandro, F., Pecere, Silvia, Gazia, C., Di Franco, G., Romano, G., Bolletta, A., Botteri, E., Di Meo, G., Chiappetta, S., Sgaramella, I., Pennestri, F., Girardi, A., Mariniello, D., Marcasciano, M., Telegrafo, M., Fracomeni, S., De Paoli, F., Mazzari A. (ORCID:0000-0002-7301-6834), Vizzielli G., Cianci S., Petrillo M., Carbone L., Patini R. (ORCID:0000-0001-7358-8763), Di Marco C., Berardi G., Calarco A., Palmisano G., and Pecere S.

Abstract

Introduction: The COVID-19 pandemic has led to the disruption of surgical training. Lack of communication, guidelines for managing clinical activity as well as concerns for safety in the workplace appeared to be relevant issues. This study aims to investigate how surgical training has been reorganized in Italy, almost 2 years after the outbreak of COVID-19 pandemic. Materials and methods: A 16-item-electronic anonymous questionnaire was designed through SurveyMonkey© web application. This survey was composed of different sections concerning demographic characteristics and impacts of the second COVID-19 pandemic wave on surgical and research/didactic activities. Changes applied in the training programme and activities carried out were also investigated. The survey was carried out in the period between June and October 2021. Results: Four hundred and thirty responses were collected, and 399 were considered eligible to be included in the study analysis. Three hundred and thirty-five respondents continued working in Surgical Units, with a significant reduction (less than one surgical session per week) of surgical sessions in 49.6% of them. With concern to didactic and research activities, 140 residents maintained their usual activity, while 116 reported a reduction. A sub-group analysis on resident moved to COVID-19 departments showed a reduction of research activities in 35% of them. During the period considered in this survey, the surgical training program was not substantially modified for most of participants (74.6%). Conclusion: Our survey demonstrated that surgical residency programs haven't improved 2 years after the beginning of the pandemic. Further improvements are needed to guarantee completeness of surgical training, even in emergency conditions.

Published
2023

4. Open abdomen management for severe peritonitis in elderly. Results from the prospective International Register of Open Abdomen (IROA): Cohort study

Author

Rausei, S, Pappalardo, V, Ceresoli, M, Catena, F, Sartelli, M, Chiarugi, M, Kluger, Y, Kirkpatrick, A, Ansaloni, L, Coccolini, F, Montori, G, Salvetti, F, Fugazzola, P, Negoi, I, Zese, M, Occhionorelli, S, Shlyapnikov, S, Demetrashvili, Z, Dondossola, D, Ioannidis, O, Novelli, G, Nacoti, M, Khor, D, Inaba, K, Demetriades, D, Kaussen, T, Jusoh, A, Ghannam, W, Sakakushev, B, Guetta, O, Dogjani, A, Costa, S, Singh, S, Damaskos, D, Isik, A, Yuan, K, Trotta, F, Martinez-Perez, A, Bellanova, G, Fonseca, V, Hernandez, F, Marinis, A, Fernandes, W, Quiodettis, M, Bala, M, Vereczkei, A, Curado, R, Fraga, G, Pereira, B, Gachabayov, M, Chagerben, G, Arellano, M, Ozyazici, S, Costa, G, Tezcaner, T, Porta, M, Li, Y, Karateke, F, Manatakis, D, Mariani, F, Lora, F, Sahderov, I, Atanasov, B, Zegarra, S, Fattori, L, Ivatury, R, Xiao, J, Lippi, A, Improta, M, Gubbiotti, F, Zharikov, A, Dubuisson, V, Sugrue, M, Rausei S., Pappalardo V., Ceresoli M., Catena F., Sartelli M., Chiarugi M., Kluger Y., Kirkpatrick A., Ansaloni L., Coccolini F., Montori G., Salvetti F., Fugazzola P., Negoi I., Zese M., Occhionorelli S., Shlyapnikov S., Demetrashvili Z., Dondossola D., Ioannidis O., Novelli G., Nacoti M., Khor D., Inaba K., Demetriades D., Kaussen T., Jusoh A. C., Ghannam W., Sakakushev B., Guetta O., Dogjani A., Costa S., Singh S., Damaskos D., Isik A., Yuan K. -C., Trotta F., Martinez-Perez A., Bellanova G., Fonseca V. C., Hernandez F., Marinis A., Fernandes W., Quiodettis M., Bala M., Vereczkei A., Curado R., Fraga G. P., Pereira B. M., Gachabayov M., Chagerben G. P., Arellano M. L., Ozyazici S., Costa G., Tezcaner T., Porta M., Li Y., Karateke F., Manatakis D., Mariani F., Lora F., Sahderov I., Atanasov B., Zegarra S., Fattori L., Ivatury R., Xiao J., Lippi A., Improta M., Gubbiotti F., Zharikov A., Dubuisson V., Sugrue M., Rausei, S, Pappalardo, V, Ceresoli, M, Catena, F, Sartelli, M, Chiarugi, M, Kluger, Y, Kirkpatrick, A, Ansaloni, L, Coccolini, F, Montori, G, Salvetti, F, Fugazzola, P, Negoi, I, Zese, M, Occhionorelli, S, Shlyapnikov, S, Demetrashvili, Z, Dondossola, D, Ioannidis, O, Novelli, G, Nacoti, M, Khor, D, Inaba, K, Demetriades, D, Kaussen, T, Jusoh, A, Ghannam, W, Sakakushev, B, Guetta, O, Dogjani, A, Costa, S, Singh, S, Damaskos, D, Isik, A, Yuan, K, Trotta, F, Martinez-Perez, A, Bellanova, G, Fonseca, V, Hernandez, F, Marinis, A, Fernandes, W, Quiodettis, M, Bala, M, Vereczkei, A, Curado, R, Fraga, G, Pereira, B, Gachabayov, M, Chagerben, G, Arellano, M, Ozyazici, S, Costa, G, Tezcaner, T, Porta, M, Li, Y, Karateke, F, Manatakis, D, Mariani, F, Lora, F, Sahderov, I, Atanasov, B, Zegarra, S, Fattori, L, Ivatury, R, Xiao, J, Lippi, A, Improta, M, Gubbiotti, F, Zharikov, A, Dubuisson, V, Sugrue, M, Rausei S., Pappalardo V., Ceresoli M., Catena F., Sartelli M., Chiarugi M., Kluger Y., Kirkpatrick A., Ansaloni L., Coccolini F., Montori G., Salvetti F., Fugazzola P., Negoi I., Zese M., Occhionorelli S., Shlyapnikov S., Demetrashvili Z., Dondossola D., Ioannidis O., Novelli G., Nacoti M., Khor D., Inaba K., Demetriades D., Kaussen T., Jusoh A. C., Ghannam W., Sakakushev B., Guetta O., Dogjani A., Costa S., Singh S., Damaskos D., Isik A., Yuan K. -C., Trotta F., Martinez-Perez A., Bellanova G., Fonseca V. C., Hernandez F., Marinis A., Fernandes W., Quiodettis M., Bala M., Vereczkei A., Curado R., Fraga G. P., Pereira B. M., Gachabayov M., Chagerben G. P., Arellano M. L., Ozyazici S., Costa G., Tezcaner T., Porta M., Li Y., Karateke F., Manatakis D., Mariani F., Lora F., Sahderov I., Atanasov B., Zegarra S., Fattori L., Ivatury R., Xiao J., Lippi A., Improta M., Gubbiotti F., Zharikov A., Dubuisson V., and Sugrue M.

Abstract

Background: Analyzing the data of the International Register of Open Abdomen (IROA), the feasibility of open abdomen treatment has been demonstrated at every age. This new analysis on the IROA database investigates the risk factors for mortality in elderly patients treated with open abdomen for intra-abdominal infection. Methods: Data were derived from the IROA, a prospective observational international cohort study that enrolled patients treated with open abdomen worldwide. A univariate analysis of potential risk factors was performed. Inclusion criteria were patients older than 65 years and treated with open abdomen for intra-abdominal infection. End point was overall mortality, calculated within 30 days after open abdomen management, after 1-month and 1-year follow-up. Results: A total of 116 patients was analyzed with mean age of 76 ± 7 years. Definitive closure was achieved in 93 patients (93/116, 80.2%) for a mean open abdomen duration of 5.0 ± 5.0 days. Complicated patients were 101 (101/116, 87.1%) for a total of 201 complications. Overall, 62 out of 116 patients (53.4%) died: 23 patients (23/62, 37.1%) during open abdomen management, 29 patients (46.8%) within 30 days after abdominal closure, 9 patients (14.5%) after 1-month follow-up, and 1 patient (1.6%) after 1-year follow-up. Age did not affect mortality (75 ± 6 years in alive patients versus 77 ± 7 years in dead patients, p = 0.773). Definitive abdominal closure was the most important factor to prevent mortality. Conclusions: This study confirmed that age alone cannot be considered a determinant for death, even in elderly patients managed with open abdomen for severe intra-abdominal infection.

Published
2020

5. Consensus Statement of the Italian Polispecialistic Society of Young Surgeons (SPIGC): Diagnosis and Treatment of Acute Appendicitis

Author

Guaitoli, E., Gallo, G., Cardone, E., Conti, L., Famularo, S., Formisano, G., Galli, F., Giuliani, G., Martino, A., Pasculli, A., Patini, Romeo, Soriero, D., Pappalardo, V., Casoni Pattacini, G., Sparavigna, M., Meniconi, R., Mazzari, A., Barra, F., Orsenigo, E., Pertile, D., Patini R. (ORCID:0000-0001-7358-8763), Guaitoli, E., Gallo, G., Cardone, E., Conti, L., Famularo, S., Formisano, G., Galli, F., Giuliani, G., Martino, A., Pasculli, A., Patini, Romeo, Soriero, D., Pappalardo, V., Casoni Pattacini, G., Sparavigna, M., Meniconi, R., Mazzari, A., Barra, F., Orsenigo, E., Pertile, D., and Patini R. (ORCID:0000-0001-7358-8763)

Abstract

Background: Acute appendicitis (AA) is one of the most common causes of abdominal pain requiring surgical intervention. Approximately 20% of AA cases are characterized by complications such as gangrene, abscesses, perforation, or diffuse peritonitis, which increase patients’ morbidity and mortality. Diagnosis of AA can be difficult, and evaluation of clinical signs, laboratory index and imaging should be part of the management of patients with suspicion of AA. Methods: This consensus statement was written in relation to the most recent evidence for diagnosis and treatment of AA, performing a literature review on the most largely adopted scientific sources. The members of the SPIGC (Italian Polispecialistic Society of Young Surgeons) worked jointly to draft it. The recommendations were defined and graded based on the current levels of evidence and in accordance with the criteria adopted by the American College of Chest Physicians (CHEST) for the strength of the recommendations. Results: Fever and migratory pain tend to be present in patients with suspicion of AA. Laboratory and radiological examinations are commonly employed in the clinical practice, but today also scoring systems based on clinical signs and laboratory data have slowly been adopted for diagnostic purpose. The clinical presentation of AA in children, pregnant and elderly patients can be unusual, leading to more difficult and delayed diagnosis. Surgery is the best option in case of complicated AA, whereas it is not mandatory in case of uncomplicated AA. Laparoscopic surgical treatment is feasible and recommended. Postoperative antibiotic treatment is recommended only in patients with complicated AA.

Published
2020

6. Measurement of the atmospheric muon flux with the NEMO Phase-1 detector

Author

Aiello, S., Ameli, F., Amore, I., Anghinolfi, M., Anzalone, A., Barbarino, G., Battaglieri, M., Bazzotti, M., Bersani, A., Beverini, N., Biagi, S., Bonori, M., Bouhadef, B., Brunoldi, M., Cacopardo, G., Capone, A., Caponetto, L., Carminati, G., Chiarusi, T., Circella, M., Cocimano, R., Coniglione, R., Cordelli, M., Costa, M., D'Amico, A., De Bonis, G., De Marzo, C., De Rosa, G., De Ruvo, G., De Vita, R., Distefano, C., Falchini, E., Flaminio, V., Fratini, K., Gabrielli, A., Galatà, S., Gandolfi, E., Giacomelli, G., Giorgi, F., Giovanetti, G., Grimaldi, A., Habel, R., Imbesi, M., Kulikovsky, V., Lattuada, D., Leonora, E., Lonardo, A., Presti, D. Lo, Lucarelli, F., Marinelli, A., Margiotta, A., Martini, A., Masullo, R., Migneco, E., Minutoli, S., Morganti, M., Musico, P., Musumeci, M., Nicolau, C. A., Orlando, A., Osipenko, M., Papaleo, R., Pappalardo, V., Piattelli, P., Piombo, D., Raia, G., Randazzo, N., Reito, S., Ricco, G., Riccobene, G., Ripani, M., Rovelli, A., Ruppi, M., Russo, G. V., Russo, S., Sapienza, P., Sciliberto, D., Sedita, M., Shirokov, E., Simeone, F., Sipala, V., Spurio, M., Taiuti, M., Trasatti, L., Urso, S., Vecchi, M., Vicini, P., Wischnewski, R., Aiello, S., Ameli, F., Amore, I., Anghinolfi, M., Anzalone, A., Barbarino, G., Battaglieri, M., Bazzotti, M., Bersani, A., Beverini, N., Biagi, S., Bonori, M., Bouhadef, B., Brunoldi, M., Cacopardo, G., Capone, A., Caponetto, L., Carminati, G., Chiarusi, T., Circella, M., Cocimano, R., Coniglione, R., Cordelli, M., Costa, M., D'Amico, A., De Bonis, G., De Marzo, C., De Rosa, G., De Ruvo, G., De Vita, R., Distefano, C., Falchini, E., Flaminio, V., Fratini, K., Gabrielli, A., Galatà, S., Gandolfi, E., Giacomelli, G., Giorgi, F., Giovanetti, G., Grimaldi, A., Habel, R., Imbesi, M., Kulikovsky, V., Lattuada, D., Leonora, E., Lonardo, A., Presti, D. Lo, Lucarelli, F., Marinelli, A., Margiotta, A., Martini, A., Masullo, R., Migneco, E., Minutoli, S., Morganti, M., Musico, P., Musumeci, M., Nicolau, C. A., Orlando, A., Osipenko, M., Papaleo, R., Pappalardo, V., Piattelli, P., Piombo, D., Raia, G., Randazzo, N., Reito, S., Ricco, G., Riccobene, G., Ripani, M., Rovelli, A., Ruppi, M., Russo, G. V., Russo, S., Sapienza, P., Sciliberto, D., Sedita, M., Shirokov, E., Simeone, F., Sipala, V., Spurio, M., Taiuti, M., Trasatti, L., Urso, S., Vecchi, M., Vicini, P., and Wischnewski, R.

Abstract

The NEMO Collaboration installed and operated an underwater detector including prototypes of the critical elements of a possible underwater km3 neutrino telescope: a four-floor tower (called Mini-Tower) and a Junction Box. The detector was developed to test some of the main systems of the km3 detector, including the data transmission, the power distribution, the timing calibration and the acoustic positioning systems as well as to verify the capabilities of a single tridimensional detection structure to reconstruct muon tracks. We present results of the analysis of the data collected with the NEMO Mini-Tower. The position of photomultiplier tubes (PMTs) is determined through the acoustic position system. Signals detected with PMTs are used to reconstruct the tracks of atmospheric muons. The angular distribution of atmospheric muons was measured and results compared with Monte Carlo simulations., Comment: Astrop. Phys., accepted

Published
2009
Full Text
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7. Measurement of the atmospheric muon flux with the NEMO Phase-1 detector

Author

Aiello, S., Ameli, F., Amore, I., Anghinolfi, M., Anzalone, A., Barbarino, G., Battaglieri, M., Bazzotti, M., Bersani, A., Beverini, N., Biagi, S., Bonori, M., Bouhadef, B., Brunoldi, M., Cacopardo, G., Capone, A., Caponetto, L., Carminati, G., Chiarusi, T., Circella, M., Cocimano, R., Coniglione, R., Cordelli, M., Costa, M., D'Amico, A., De Bonis, G., De Marzo, C., De Rosa, G., De Ruvo, G., De Vita, R., Distefano, C., Falchini, E., Flaminio, V., Fratini, K., Gabrielli, A., Galatà, S., Gandolfi, E., Giacomelli, G., Giorgi, F., Giovanetti, G., Grimaldi, A., Habel, R., Imbesi, M., Kulikovsky, V., Lattuada, D., Leonora, E., Lonardo, A., Presti, D. Lo, Lucarelli, F., Marinelli, A., Margiotta, A., Martini, A., Masullo, R., Migneco, E., Minutoli, S., Morganti, M., Musico, P., Musumeci, M., Nicolau, C. A., Orlando, A., Osipenko, M., Papaleo, R., Pappalardo, V., Piattelli, P., Piombo, D., Raia, G., Randazzo, N., Reito, S., Ricco, G., Riccobene, G., Ripani, M., Rovelli, A., Ruppi, M., Russo, G. V., Russo, S., Sapienza, P., Sciliberto, D., Sedita, M., Shirokov, E., Simeone, F., Sipala, V., Spurio, M., Taiuti, M., Trasatti, L., Urso, S., Vecchi, M., Vicini, P., Wischnewski, R., Aiello, S., Ameli, F., Amore, I., Anghinolfi, M., Anzalone, A., Barbarino, G., Battaglieri, M., Bazzotti, M., Bersani, A., Beverini, N., Biagi, S., Bonori, M., Bouhadef, B., Brunoldi, M., Cacopardo, G., Capone, A., Caponetto, L., Carminati, G., Chiarusi, T., Circella, M., Cocimano, R., Coniglione, R., Cordelli, M., Costa, M., D'Amico, A., De Bonis, G., De Marzo, C., De Rosa, G., De Ruvo, G., De Vita, R., Distefano, C., Falchini, E., Flaminio, V., Fratini, K., Gabrielli, A., Galatà, S., Gandolfi, E., Giacomelli, G., Giorgi, F., Giovanetti, G., Grimaldi, A., Habel, R., Imbesi, M., Kulikovsky, V., Lattuada, D., Leonora, E., Lonardo, A., Presti, D. Lo, Lucarelli, F., Marinelli, A., Margiotta, A., Martini, A., Masullo, R., Migneco, E., Minutoli, S., Morganti, M., Musico, P., Musumeci, M., Nicolau, C. A., Orlando, A., Osipenko, M., Papaleo, R., Pappalardo, V., Piattelli, P., Piombo, D., Raia, G., Randazzo, N., Reito, S., Ricco, G., Riccobene, G., Ripani, M., Rovelli, A., Ruppi, M., Russo, G. V., Russo, S., Sapienza, P., Sciliberto, D., Sedita, M., Shirokov, E., Simeone, F., Sipala, V., Spurio, M., Taiuti, M., Trasatti, L., Urso, S., Vecchi, M., Vicini, P., and Wischnewski, R.

Abstract

The NEMO Collaboration installed and operated an underwater detector including prototypes of the critical elements of a possible underwater km3 neutrino telescope: a four-floor tower (called Mini-Tower) and a Junction Box. The detector was developed to test some of the main systems of the km3 detector, including the data transmission, the power distribution, the timing calibration and the acoustic positioning systems as well as to verify the capabilities of a single tridimensional detection structure to reconstruct muon tracks. We present results of the analysis of the data collected with the NEMO Mini-Tower. The position of photomultiplier tubes (PMTs) is determined through the acoustic position system. Signals detected with PMTs are used to reconstruct the tracks of atmospheric muons. The angular distribution of atmospheric muons was measured and results compared with Monte Carlo simulations., Comment: Astrop. Phys., accepted

Published
2009
Full Text
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8. Multifragmentation and Flow: peripheral vs. central collisions

Author

Pochodzalla, J., Aiello, S., Begemann-Blaich, M., Bowman, D. R., Charity, R. J., Cosmo, A., Ferrero, A., Gelbke, C. K., Hsi, W. C., Hubele, J., Imme, G., Iori, I., Kempter, J., Kreutz, P., Kunde, G. J., Kunze, W. D., Lindenstruth, V., Lisa, M. A., Lynch, W. G., Lynen, U., Mang, M., Moretto, L. G., Moroni, A., Müller, W. F. J., Neumann, M., Ocker, B., Ogilvie, C. A., Pappalardo, V., Peaslee, G. F., Raciti, G., Rosenberger, F., Rubehn, T., Sann, H., Scardaoni, R., Schüttauf, A., Seidel, W., Serfling, V., Sobotka, L. G., Stroth, J., Stuttge, L., Trautmann, W., Tsang, M. B., Tucholski, A., Williams, C. W., Wörner, A., Zude, E., Zwieglinski, B., Blaich, T., Pochodzalla, J., Aiello, S., Begemann-Blaich, M., Bowman, D. R., Charity, R. J., Cosmo, A., Ferrero, A., Gelbke, C. K., Hsi, W. C., Hubele, J., Imme, G., Iori, I., Kempter, J., Kreutz, P., Kunde, G. J., Kunze, W. D., Lindenstruth, V., Lisa, M. A., Lynch, W. G., Lynen, U., Mang, M., Moretto, L. G., Moroni, A., Müller, W. F. J., Neumann, M., Ocker, B., Ogilvie, C. A., Pappalardo, V., Peaslee, G. F., Raciti, G., Rosenberger, F., Rubehn, T., Sann, H., Scardaoni, R., Schüttauf, A., Seidel, W., Serfling, V., Sobotka, L. G., Stroth, J., Stuttge, L., Trautmann, W., Tsang, M. B., Tucholski, A., Williams, C. W., Wörner, A., Zude, E., Zwieglinski, B., and Blaich, T.

Published
1995

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