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2 results on '"Papay, Pavol"'

1. H1N1 vaccines in a large observational cohort of patients with inflammatory bowel disease treated with immunomodulators and biological therapy.

Author

UCL - (MGD) Service de gastro-entérologie, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - SSS/IREC/GAEN - Pôle d'Hépato-gastro-entérologie, Rahier, Jean-François, Papay, Pavol, Salleron, Julia, Sebastian, Shaji, Marzo, Manuela, Peyrin-Biroulet, Laurent, Garcia-Sanchez, Valle, Fries, Walter, van Asseldonk, Dirk P, Farkas, Klaudia, de Boer, Nanne K, Sipponen, Taina, Ellul, Pierre, Louis, Edouard, Peake, Simon T C, Kopylov, Uri, Maul, Jochen, Makhoul, Badira, Fiorino, Gionata, Yazdanpanah, Yazdan, Chaparro, Maria, UCL - (MGD) Service de gastro-entérologie, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - SSS/IREC/GAEN - Pôle d'Hépato-gastro-entérologie, Rahier, Jean-François, Papay, Pavol, Salleron, Julia, Sebastian, Shaji, Marzo, Manuela, Peyrin-Biroulet, Laurent, Garcia-Sanchez, Valle, Fries, Walter, van Asseldonk, Dirk P, Farkas, Klaudia, de Boer, Nanne K, Sipponen, Taina, Ellul, Pierre, Louis, Edouard, Peake, Simon T C, Kopylov, Uri, Maul, Jochen, Makhoul, Badira, Fiorino, Gionata, Yazdanpanah, Yazdan, and Chaparro, Maria

Abstract

Influenza A (H1N1)v vaccines are well tolerated in patients with IBD. Non-adjuvanted vaccines are associated with fewer local reactions. The risk of IBD flare is probably not increased after H1N1 vaccination.

Published
2011

2. Severe Skin Lesions Cause Patients with Inflammatory Bowel Disease to Discontinue Anti-Tumor Necrosis Factor Therapy.

Author

UCL - (MGD) Service de gastro-entérologie, UCL - SSS/IREC/GAEN - Pôle d'Hépato-gastro-entérologie, Rahier, Jean-François, Buche, Sébastien, Biroulet, Laurent Peyrin, Bouhnik, Yoram, Duclos, Bernard, Louis, Edouard, Papay, Pavol, Allez, Matthieu, Cosnes, Jacques, Cortot, Antoine, Laharie, David, Reimund, Jean-Marie, Lémann, Marc, Delaporte, Emmanuel, Colombel, Jean-Frédéric, Groupe d’Etude Thérapeutique des Affections Inflammatoires du Tube Digestif (GETAID), UCL - (MGD) Service de gastro-entérologie, UCL - SSS/IREC/GAEN - Pôle d'Hépato-gastro-entérologie, Rahier, Jean-François, Buche, Sébastien, Biroulet, Laurent Peyrin, Bouhnik, Yoram, Duclos, Bernard, Louis, Edouard, Papay, Pavol, Allez, Matthieu, Cosnes, Jacques, Cortot, Antoine, Laharie, David, Reimund, Jean-Marie, Lémann, Marc, Delaporte, Emmanuel, Colombel, Jean-Frédéric, and Groupe d’Etude Thérapeutique des Affections Inflammatoires du Tube Digestif (GETAID)

Abstract

BACKGROUND & AIMS:: Psoriasiform and eczematiform lesions are associated with anti-tumor necrosis factor (TNF)-alpha therapies. We assessed clinical characteristics, risk factors, and outcomes of skin disease in patients with inflammatory bowel diseases that presented with psoriasiform and eczematiform lesions induced by anti-TNFalpha agents. METHODS:: We studied 85 patients (69 with Crohn's disease, 15 with ulcerative colitis, and 1 with indeterminate colitis; 62 women) with inflammatory skin lesions (62 psoriasiform and 23 eczematiform lesions). RESULTS:: Twenty-four patients had a history of inflammatory skin lesions and 15 had a familial history of inflammatory skin disease. Locations of eczematiform lesions varied whereas scalp and flexural varieties were mostly psoriasiform. Skin lesions emerged but inflammatory bowel disease was quiescent in 69 patients following treatment with any type of anti-TNFalpha agent (60 with infliximab, 20 with adalimumab, and 5 with certolizumab). Topical therapy resulted in partial or total remission in 41 patients. Patients with psoriasifom lesions that were resistant to topical therapy and that changed anti-TNFalpha therapies once or twice developed recurring lesions. Overall, uncontrolled skin lesions caused 29 patients to stop taking TNFalpha inhibitors. CONCLUSION:: Inflammatory skin lesions following therapy with TNFalpha inhibitors occurred most frequently among women and patients with a personal or familial history of inflammatory skin disease; lesions did not correlate with intestinal disease activity. Recurring and intense skin lesions caused 34% of patients in this study to discontinue use of anti-TNFalpha agents.

Published
2010

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