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1. The consequences of the new European reclassification of non-invasive brain stimulation devices and the medical device regulations pose an existential threat to research and treatment: An invited opinion paper

Author

Antal, Andrea, Antal, Andrea, Ganho-Ávila, Ana, Assecondi, Sara, Barbour, Tracy, Bjekić, Jovana, Blumberger, Daniel M., Bolognini, Nadia, Brunelin, Jerome, Chanes, Lorena, Dale, Matthew, Dubbioso, Raffaele, D'Urso, Giordano, Filipčić, Igor, Filipović, Saša, Hirnstein, Marco, Konings, Femke, Langguth, Berthold, Leocani, Letizia, Sorkhabi, Majid Memarian, Mulder, Marc, Nikander, Mika, Nowak, Rafal, Oliviero, Antonio, Onarheim, Balder, O'Shea, Jacinta, Pallanti, Stefano, Rachid, Fady, Rajão-Saraiva, Joana, Rossi, Simone, Sack, Alexander T., Sauvaget, Anne, van der Scheer, Rik, Schellhorn, Klaus, Soria-Frisch, Aureli, Szekely, David, Tankisi, Hatice, Taylor, Paul CJ., Tendolkar, Indira, Uusitalo, Susanne, Baeken, Chris, Antal, Andrea, Antal, Andrea, Ganho-Ávila, Ana, Assecondi, Sara, Barbour, Tracy, Bjekić, Jovana, Blumberger, Daniel M., Bolognini, Nadia, Brunelin, Jerome, Chanes, Lorena, Dale, Matthew, Dubbioso, Raffaele, D'Urso, Giordano, Filipčić, Igor, Filipović, Saša, Hirnstein, Marco, Konings, Femke, Langguth, Berthold, Leocani, Letizia, Sorkhabi, Majid Memarian, Mulder, Marc, Nikander, Mika, Nowak, Rafal, Oliviero, Antonio, Onarheim, Balder, O'Shea, Jacinta, Pallanti, Stefano, Rachid, Fady, Rajão-Saraiva, Joana, Rossi, Simone, Sack, Alexander T., Sauvaget, Anne, van der Scheer, Rik, Schellhorn, Klaus, Soria-Frisch, Aureli, Szekely, David, Tankisi, Hatice, Taylor, Paul CJ., Tendolkar, Indira, Uusitalo, Susanne, and Baeken, Chris

Abstract

A significant amount of European basic and clinical neuroscience research includes the use of transcranial magnetic stimulation (TMS) and low intensity transcranial electrical stimulation (tES), mainly transcranial direct current stimulation (tDCS). Two recent changes in the EU regulations, the introduction of the Medical Device Regulation (MDR) (2017/745) and the Annex XVI have caused significant problems and confusions in the brain stimulation field. The negative consequences of the MDR for non-invasive brain stimulation (NIBS) have been largely overlooked and until today, have not been consequently addressed by National Competent Authorities, local ethical committees, politicians and by the scientific communities. In addition, a rushed bureaucratic decision led to seemingly wrong classification of NIBS products without an intended medical purpose into the same risk group III as invasive stimulators. Overregulation is detrimental for any research and for future developments, therefore researchers, clinicians, industry, patient representatives and an ethicist were invited to contribute to this document with the aim of starting a constructive dialogue and enacting positive changes in the regulatory environment.

Published
2024

2. The consequences of the new European reclassification of non-invasive brain stimulation devices and the medical device regulations pose an existential threat to research and treatment: An invited opinion paper

Author

Antal, Andrea, Ganho-Ávila, Ana, Assecondi, Sara, Barbour, Tracy, Bjekić, Jovana, Blumberger, Daniel M, Bolognini, Nadia, Brunelin, Jerome, Chanes, Lorena, Dale, Matthew, Dubbioso, Raffaele, D'Urso, Giordano, Filipcic, Igor, Filipović, Saša R, Hirnstein, Marco, Konings, Femke, Langguth, Berthold, Leocani, Letizia, Sorkhabi, Majid Memarian, Mulder, Marc, Nikander, Mika, Nowak, Rafal, Oliviero, Antonio, Onarheim, Balder, O'Shea, Jacinta, Pallanti, Stefano, Rachid, Fady, Rajão-Saraiva, Joana, Rossi, Simone, Sack, Alexander T, Sauvaget, Anne, van der Scheer, Rik, Schellhorn, Klaus, Soria-Frisch, Aureli, Szekely, David, Tankisi, Hatice, Cj Taylor, Paul, Tendolkar, Indira, Uusitalo, Susanne, Baeken, Chris, Antal, Andrea, Ganho-Ávila, Ana, Assecondi, Sara, Barbour, Tracy, Bjekić, Jovana, Blumberger, Daniel M, Bolognini, Nadia, Brunelin, Jerome, Chanes, Lorena, Dale, Matthew, Dubbioso, Raffaele, D'Urso, Giordano, Filipcic, Igor, Filipović, Saša R, Hirnstein, Marco, Konings, Femke, Langguth, Berthold, Leocani, Letizia, Sorkhabi, Majid Memarian, Mulder, Marc, Nikander, Mika, Nowak, Rafal, Oliviero, Antonio, Onarheim, Balder, O'Shea, Jacinta, Pallanti, Stefano, Rachid, Fady, Rajão-Saraiva, Joana, Rossi, Simone, Sack, Alexander T, Sauvaget, Anne, van der Scheer, Rik, Schellhorn, Klaus, Soria-Frisch, Aureli, Szekely, David, Tankisi, Hatice, Cj Taylor, Paul, Tendolkar, Indira, Uusitalo, Susanne, and Baeken, Chris

Abstract

A significant amount of European basic and clinical neuroscience research includes the use of transcranial magnetic stimulation (TMS) and low intensity transcranial electrical stimulation (tES), mainly transcranial direct current stimulation (tDCS). Two recent changes in the EU regulations, the introduction of the Medical Device Regulation (MDR) (2017/745) and the Annex XVI have caused significant problems and confusions in the brain stimulation field. The negative consequences of the MDR for non-invasive brain stimulation (NIBS) have been largely overlooked and until today, have not been consequently addressed by National Competent Authorities, local ethical committees, politicians and by the scientific communities. In addition, a rushed bureaucratic decision led to seemingly wrong classification of NIBS products without an intended medical purpose into the same risk group III as invasive stimulators. Overregulation is detrimental for any research and for future developments, therefore researchers, clinicians, industry, patient representatives and an ethicist were invited to contribute to this document with the aim of starting a constructive dialogue and enacting positive changes in the regulatory environment. [Abstract copyright: Copyright © 2024 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.]

Published
2024

3. The consequences of the new European reclassification of non-invasive brain stimulation devices and the medical device regulations pose an existential threat to research and treatment: An invited opinion paper

Author

Antal, Andrea, Ganho-Ávila, Ana, Assecondi, Sara, Barbour, Tracy, Bjekić, Jovana, Blumberger, Daniel M, Bolognini, Nadia, Brunelin, Jerome, Chanes, Lorena, Dale, Matthew, Dubbioso, Raffaele, D'Urso, Giordano, Filipcic, Igor, Filipović, Saša R, Hirnstein, Marco, Konings, Femke, Langguth, Berthold, Leocani, Letizia, Sorkhabi, Majid Memarian, Mulder, Marc, Nikander, Mika, Nowak, Rafal, Oliviero, Antonio, Onarheim, Balder, O'Shea, Jacinta, Pallanti, Stefano, Rachid, Fady, Rajão-Saraiva, Joana, Rossi, Simone, Sack, Alexander T, Sauvaget, Anne, van der Scheer, Rik, Schellhorn, Klaus, Soria-Frisch, Aureli, Szekely, David, Tankisi, Hatice, Cj Taylor, Paul, Tendolkar, Indira, Uusitalo, Susanne, Baeken, Chris, Antal, Andrea, Ganho-Ávila, Ana, Assecondi, Sara, Barbour, Tracy, Bjekić, Jovana, Blumberger, Daniel M, Bolognini, Nadia, Brunelin, Jerome, Chanes, Lorena, Dale, Matthew, Dubbioso, Raffaele, D'Urso, Giordano, Filipcic, Igor, Filipović, Saša R, Hirnstein, Marco, Konings, Femke, Langguth, Berthold, Leocani, Letizia, Sorkhabi, Majid Memarian, Mulder, Marc, Nikander, Mika, Nowak, Rafal, Oliviero, Antonio, Onarheim, Balder, O'Shea, Jacinta, Pallanti, Stefano, Rachid, Fady, Rajão-Saraiva, Joana, Rossi, Simone, Sack, Alexander T, Sauvaget, Anne, van der Scheer, Rik, Schellhorn, Klaus, Soria-Frisch, Aureli, Szekely, David, Tankisi, Hatice, Cj Taylor, Paul, Tendolkar, Indira, Uusitalo, Susanne, and Baeken, Chris

Abstract

A significant amount of European basic and clinical neuroscience research includes the use of transcranial magnetic stimulation (TMS) and low intensity transcranial electrical stimulation (tES), mainly transcranial direct current stimulation (tDCS). Two recent changes in the EU regulations, the introduction of the Medical Device Regulation (MDR) (2017/745) and the Annex XVI have caused significant problems and confusions in the brain stimulation field. The negative consequences of the MDR for non-invasive brain stimulation (NIBS) have been largely overlooked and until today, have not been consequently addressed by National Competent Authorities, local ethical committees, politicians and by the scientific communities. In addition, a rushed bureaucratic decision led to seemingly wrong classification of NIBS products without an intended medical purpose into the same risk group III as invasive stimulators. Overregulation is detrimental for any research and for future developments, therefore researchers, clinicians, industry, patient representatives and an ethicist were invited to contribute to this document with the aim of starting a constructive dialogue and enacting positive changes in the regulatory environment. [Abstract copyright: Copyright © 2024 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.]

Published
2024

4. World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for treatment of anxiety, obsessive-compulsive and posttraumatic stress disorders - Version 3. Part II : OCD and PTSD

Author

Bandelow, Borwin, Allgulander, Christer, Baldwin, David S., da Conceicao Costa, Daniel Lucas, Denys, Damiaan, Dilbaz, Nesrin, Domschke, Katharina, Hollander, Eric, Kasper, Siegfried, Moeller, Hans-Juergen, Eriksson, Elias, Fineberg, Naomi A., Haettenschwiler, Josef, Kaiya, Hisanobu, Karavaeva, Tatiana, Katzman, Martin A., Kim, Yong-Ku, Inoue, Takeshi, Lim, Leslie, Masdrakis, Vasilios, Menchon, Jose M., Miguel, Euripedes C., Nardi, Antonio E., Pallanti, Stefano, Perna, Giampaolo, Rujescu, Dan, Starcevic, Vladan, Stein, Dan J., Tsai, Shih-Jen, Van Ameringen, Michael, Vasileva, Anna, Wang, Zhen, Zohar, Joseph, Bandelow, Borwin, Allgulander, Christer, Baldwin, David S., da Conceicao Costa, Daniel Lucas, Denys, Damiaan, Dilbaz, Nesrin, Domschke, Katharina, Hollander, Eric, Kasper, Siegfried, Moeller, Hans-Juergen, Eriksson, Elias, Fineberg, Naomi A., Haettenschwiler, Josef, Kaiya, Hisanobu, Karavaeva, Tatiana, Katzman, Martin A., Kim, Yong-Ku, Inoue, Takeshi, Lim, Leslie, Masdrakis, Vasilios, Menchon, Jose M., Miguel, Euripedes C., Nardi, Antonio E., Pallanti, Stefano, Perna, Giampaolo, Rujescu, Dan, Starcevic, Vladan, Stein, Dan J., Tsai, Shih-Jen, Van Ameringen, Michael, Vasileva, Anna, Wang, Zhen, and Zohar, Joseph

Abstract

Aim: This is the third version of the guideline of the World Federation of Societies of Biological Psychiatry (WFSBP) Task Force for the Pharmacological Treatment of Anxiety, Obsessive-Compulsive and Posttraumatic Stress Disorders which was published in 2002 and revised in 2008. Method: A consensus panel of 34 international experts representing 22 countries developed recommendations based on efficacy and acceptability of the treatments. In this version, not only medications but also psychotherapies and other non-pharmacological interventions were evaluated, applying the same rigorous methods that are standard for the assessment of medication treatments. Result: The present paper (Part II) contains recommendations based on published randomised controlled trials (RCTs) for the treatment of OCD (n = 291) and PTSD (n = 234) in children, adolescents, and adults. The accompanying paper (Part I) contains the recommendations for the treatment of anxiety disorders. For OCD, first-line treatments are selective serotonin reuptake inhibitors (SSRIs) and cognitive behavioural therapy (CBT). Internet-CBT was also superior to active controls. Several second-line medications are available, including clomipramine. For treatment-resistant cases, several options are available, including augmentation of SSRI treatment with antipsychotics and other drugs. Other non-pharmacological treatments, including repetitive transcranial magnetic stimulation (rTMS), deep brain stimulation (DBS) and others were also evaluated. For PTSD, SSRIs and the SNRI venlafaxine are first-line treatments. CBT is the psychotherapy modality with the best body of evidence. For treatment-unresponsive patients, augmentation of SSRI treatment with antipsychotics may be an option. Conclusion: OCD and PTSD can be effectively treated with CBT and medications.

Published
2023
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5. World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for treatment of anxiety, obsessive-compulsive and posttraumatic stress disorders : Version 3. Part I: Anxiety disorders

Author

Bandelow, Borwin, Allgulander, Christer, Baldwin, David S., da Conceicao Costa, Daniel Lucas, Denys, Damiaan, Dilbaz, Nesrin, Domschke, Katharina, Eriksson, Elias, Fineberg, Naomi A., Hättenschwiler, Josef, Hollander, Eric, Kaiya, Hisanobu, Karavaeva, Tatiana, Kasper, Siegfried, Katzman, Martin, Kim, Yong-Ku, Inoue, Takeshi, Lim, Leslie, Masdrakis, Vasilios, Menchon, Jose M., Miguel, Euripedes C., Moller, Hans-Jürgen, Nardi, Antonio E., Pallanti, Stefano, Perna, Giampaolo, Rujescu, Dan, Starcevic, Vladan, Stein, Dan J., Tsai, Shih-Jen, Van Ameringen, Michael, Vasileva, Anna, Wang, Zhen, Zohar, Joseph, Bandelow, Borwin, Allgulander, Christer, Baldwin, David S., da Conceicao Costa, Daniel Lucas, Denys, Damiaan, Dilbaz, Nesrin, Domschke, Katharina, Eriksson, Elias, Fineberg, Naomi A., Hättenschwiler, Josef, Hollander, Eric, Kaiya, Hisanobu, Karavaeva, Tatiana, Kasper, Siegfried, Katzman, Martin, Kim, Yong-Ku, Inoue, Takeshi, Lim, Leslie, Masdrakis, Vasilios, Menchon, Jose M., Miguel, Euripedes C., Moller, Hans-Jürgen, Nardi, Antonio E., Pallanti, Stefano, Perna, Giampaolo, Rujescu, Dan, Starcevic, Vladan, Stein, Dan J., Tsai, Shih-Jen, Van Ameringen, Michael, Vasileva, Anna, Wang, Zhen, and Zohar, Joseph

Abstract

Aim This is the third version of the guideline of the World Federation of Societies of Biological Psychiatry (WFSBP) Task Force for the Pharmacological Treatment of Anxiety, Obsessive-Compulsive and Posttraumatic Stress Disorders (published in 2002, revised in 2008). Method A consensus panel of 33 international experts representing 22 countries developed recommendations based on efficacy and acceptability of available treatments. In total, 1007 RCTs for the treatment of these disorders in adults, adolescents, and children with medications, psychotherapy and other non-pharmacological interventions were evaluated, applying the same rigorous methods that are standard for the assessment of medications. Result This paper, Part I, contains recommendations for the treatment of panic disorder/agoraphobia (PDA), generalised anxiety disorder (GAD), social anxiety disorder (SAD), specific phobias, mixed anxiety disorders in children and adolescents, separation anxiety and selective mutism. Selective serotonin reuptake inhibitors (SSRI) and serotonin-norepinephrine reuptake inhibitors (SNRIs) are first-line medications. Cognitive behavioural therapy (CBT) is the first-line psychotherapy for anxiety disorders. The expert panel also made recommendations for patients not responding to standard treatments and recommendations against interventions with insufficient evidence. Conclusion It is the goal of this initiative to provide treatment guidance for these disorders that has validity throughout the world.

Published
2023
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6. A Delphi-method-based consensus guideline for definition of treatment-resistant depression for clinical trials.

Author

Sforzini, Luca, Sforzini, Luca, Worrell, Courtney, Kose, Melisa, Anderson, Ian M, Aouizerate, Bruno, Arolt, Volker, Bauer, Michael, Baune, Bernhard T, Blier, Pierre, Cleare, Anthony J, Cowen, Philip J, Dinan, Timothy G, Fagiolini, Andrea, Ferrier, I Nicol, Hegerl, Ulrich, Krystal, Andrew D, Leboyer, Marion, McAllister-Williams, R Hamish, McIntyre, Roger S, Meyer-Lindenberg, Andreas, Miller, Andrew H, Nemeroff, Charles B, Normann, Claus, Nutt, David, Pallanti, Stefano, Pani, Luca, Penninx, Brenda WJH, Schatzberg, Alan F, Shelton, Richard C, Yatham, Lakshmi N, Young, Allan H, Zahn, Roland, Aislaitner, Georgios, Butlen-Ducuing, Florence, Fletcher, Christine, Haberkamp, Marion, Laughren, Thomas, Mäntylä, Fanni-Laura, Schruers, Koen, Thomson, Andrew, Arteaga-Henríquez, Gara, Benedetti, Francesco, Cash-Gibson, Lucinda, Chae, Woo Ri, De Smedt, Heidi, Gold, Stefan M, Hoogendijk, Witte JG, Mondragón, Valeria Jordán, Maron, Eduard, Martynowicz, Jadwiga, Melloni, Elisa, Otte, Christian, Perez-Fuentes, Gabriela, Poletti, Sara, Schmidt, Mark E, van de Ketterij, Edwin, Woo, Katherine, Flossbach, Yanina, Ramos-Quiroga, J Antoni, Savitz, Adam J, Pariante, Carmine M, Sforzini, Luca, Sforzini, Luca, Worrell, Courtney, Kose, Melisa, Anderson, Ian M, Aouizerate, Bruno, Arolt, Volker, Bauer, Michael, Baune, Bernhard T, Blier, Pierre, Cleare, Anthony J, Cowen, Philip J, Dinan, Timothy G, Fagiolini, Andrea, Ferrier, I Nicol, Hegerl, Ulrich, Krystal, Andrew D, Leboyer, Marion, McAllister-Williams, R Hamish, McIntyre, Roger S, Meyer-Lindenberg, Andreas, Miller, Andrew H, Nemeroff, Charles B, Normann, Claus, Nutt, David, Pallanti, Stefano, Pani, Luca, Penninx, Brenda WJH, Schatzberg, Alan F, Shelton, Richard C, Yatham, Lakshmi N, Young, Allan H, Zahn, Roland, Aislaitner, Georgios, Butlen-Ducuing, Florence, Fletcher, Christine, Haberkamp, Marion, Laughren, Thomas, Mäntylä, Fanni-Laura, Schruers, Koen, Thomson, Andrew, Arteaga-Henríquez, Gara, Benedetti, Francesco, Cash-Gibson, Lucinda, Chae, Woo Ri, De Smedt, Heidi, Gold, Stefan M, Hoogendijk, Witte JG, Mondragón, Valeria Jordán, Maron, Eduard, Martynowicz, Jadwiga, Melloni, Elisa, Otte, Christian, Perez-Fuentes, Gabriela, Poletti, Sara, Schmidt, Mark E, van de Ketterij, Edwin, Woo, Katherine, Flossbach, Yanina, Ramos-Quiroga, J Antoni, Savitz, Adam J, and Pariante, Carmine M

Abstract

Criteria for treatment-resistant depression (TRD) and partially responsive depression (PRD) as subtypes of major depressive disorder (MDD) are not unequivocally defined. In the present document we used a Delphi-method-based consensus approach to define TRD and PRD and to serve as operational criteria for future clinical studies, especially if conducted for regulatory purposes. We reviewed the literature and brought together a group of international experts (including clinicians, academics, researchers, employees of pharmaceutical companies, regulatory bodies representatives, and one person with lived experience) to evaluate the state-of-the-art and main controversies regarding the current classification. We then provided recommendations on how to design clinical trials, and on how to guide research in unmet needs and knowledge gaps. This report will feed into one of the main objectives of the EUropean Patient-cEntric clinicAl tRial pLatforms, Innovative Medicines Initiative (EU-PEARL, IMI) MDD project, to design a protocol for platform trials of new medications for TRD/PRD.

Published
2022

7. A Delphi-method-based consensus guideline for definition of treatment-resistant depression for clinical trials.

Author

Sforzini, Luca, Sforzini, Luca, Worrell, Courtney, Kose, Melisa, Anderson, Ian M, Aouizerate, Bruno, Arolt, Volker, Bauer, Michael, Baune, Bernhard T, Blier, Pierre, Cleare, Anthony J, Cowen, Philip J, Dinan, Timothy G, Fagiolini, Andrea, Ferrier, I Nicol, Hegerl, Ulrich, Krystal, Andrew D, Leboyer, Marion, McAllister-Williams, R Hamish, McIntyre, Roger S, Meyer-Lindenberg, Andreas, Miller, Andrew H, Nemeroff, Charles B, Normann, Claus, Nutt, David, Pallanti, Stefano, Pani, Luca, Penninx, Brenda WJH, Schatzberg, Alan F, Shelton, Richard C, Yatham, Lakshmi N, Young, Allan H, Zahn, Roland, Aislaitner, Georgios, Butlen-Ducuing, Florence, Fletcher, Christine, Haberkamp, Marion, Laughren, Thomas, Mäntylä, Fanni-Laura, Schruers, Koen, Thomson, Andrew, Arteaga-Henríquez, Gara, Benedetti, Francesco, Cash-Gibson, Lucinda, Chae, Woo Ri, De Smedt, Heidi, Gold, Stefan M, Hoogendijk, Witte JG, Mondragón, Valeria Jordán, Maron, Eduard, Martynowicz, Jadwiga, Melloni, Elisa, Otte, Christian, Perez-Fuentes, Gabriela, Poletti, Sara, Schmidt, Mark E, van de Ketterij, Edwin, Woo, Katherine, Flossbach, Yanina, Ramos-Quiroga, J Antoni, Savitz, Adam J, Pariante, Carmine M, Sforzini, Luca, Sforzini, Luca, Worrell, Courtney, Kose, Melisa, Anderson, Ian M, Aouizerate, Bruno, Arolt, Volker, Bauer, Michael, Baune, Bernhard T, Blier, Pierre, Cleare, Anthony J, Cowen, Philip J, Dinan, Timothy G, Fagiolini, Andrea, Ferrier, I Nicol, Hegerl, Ulrich, Krystal, Andrew D, Leboyer, Marion, McAllister-Williams, R Hamish, McIntyre, Roger S, Meyer-Lindenberg, Andreas, Miller, Andrew H, Nemeroff, Charles B, Normann, Claus, Nutt, David, Pallanti, Stefano, Pani, Luca, Penninx, Brenda WJH, Schatzberg, Alan F, Shelton, Richard C, Yatham, Lakshmi N, Young, Allan H, Zahn, Roland, Aislaitner, Georgios, Butlen-Ducuing, Florence, Fletcher, Christine, Haberkamp, Marion, Laughren, Thomas, Mäntylä, Fanni-Laura, Schruers, Koen, Thomson, Andrew, Arteaga-Henríquez, Gara, Benedetti, Francesco, Cash-Gibson, Lucinda, Chae, Woo Ri, De Smedt, Heidi, Gold, Stefan M, Hoogendijk, Witte JG, Mondragón, Valeria Jordán, Maron, Eduard, Martynowicz, Jadwiga, Melloni, Elisa, Otte, Christian, Perez-Fuentes, Gabriela, Poletti, Sara, Schmidt, Mark E, van de Ketterij, Edwin, Woo, Katherine, Flossbach, Yanina, Ramos-Quiroga, J Antoni, Savitz, Adam J, and Pariante, Carmine M

Abstract

Criteria for treatment-resistant depression (TRD) and partially responsive depression (PRD) as subtypes of major depressive disorder (MDD) are not unequivocally defined. In the present document we used a Delphi-method-based consensus approach to define TRD and PRD and to serve as operational criteria for future clinical studies, especially if conducted for regulatory purposes. We reviewed the literature and brought together a group of international experts (including clinicians, academics, researchers, employees of pharmaceutical companies, regulatory bodies representatives, and one person with lived experience) to evaluate the state-of-the-art and main controversies regarding the current classification. We then provided recommendations on how to design clinical trials, and on how to guide research in unmet needs and knowledge gaps. This report will feed into one of the main objectives of the EUropean Patient-cEntric clinicAl tRial pLatforms, Innovative Medicines Initiative (EU-PEARL, IMI) MDD project, to design a protocol for platform trials of new medications for TRD/PRD.

Published
2022

8. A Delphi-method-based consensus guideline for definition of treatment-resistant depression for clinical trials

Author

Sforzini, Luca, Worrell, Courtney, Kose, Melisa, Anderson, Ian M., Aouizerate, Bruno, Arolt, Volker, Bauer, Michael, Baune, Bernhard T., Blier, Pierre, Cleare, Anthony J., Cowen, Philip J., Dinan, Timothy G., Fagiolini, Andrea, Ferrier, I. Nicol, Hegerl, Ulrich, Krystal, Andrew D., Leboyer, Marion, McAllister-Williams, R. Hamish, McIntyre, Roger S., Meyer-Lindenberg, Andreas, Miller, Andrew H., Nemeroff, Charles B., Normann, Claus, Nutt, David, Pallanti, Stefano, Pani, Luca, Penninx, Brenda W.J.H., Schatzberg, Alan F., Shelton, Richard C., Yatham, Lakshmi N., Young, Allan H., Zahn, Roland, Aislaitner, Georgios, Butlen-Ducuing, Florence, Fletcher, Christine, Haberkamp, Marion, Laughren, Thomas, Mäntylä, Fanni Laura, Schruers, Koen, Thomson, Andrew, Arteaga-Henríquez, Gara, Benedetti, Francesco, Cash-Gibson, Lucinda, Chae, Woo Ri, De Smedt, Heidi, Gold, Stefan M., Hoogendijk, Witte J.G., Mondragón, Valeria Jordán, Maron, Eduard, Martynowicz, Jadwiga, Melloni, Elisa, Otte, Christian, Perez-Fuentes, Gabriela, Poletti, Sara, Schmidt, Mark E., van de Ketterij, Edwin, Woo, Katherine, Flossbach, Yanina, Ramos-Quiroga, J. Antoni, Savitz, Adam J., Pariante, Carmine M., Sforzini, Luca, Worrell, Courtney, Kose, Melisa, Anderson, Ian M., Aouizerate, Bruno, Arolt, Volker, Bauer, Michael, Baune, Bernhard T., Blier, Pierre, Cleare, Anthony J., Cowen, Philip J., Dinan, Timothy G., Fagiolini, Andrea, Ferrier, I. Nicol, Hegerl, Ulrich, Krystal, Andrew D., Leboyer, Marion, McAllister-Williams, R. Hamish, McIntyre, Roger S., Meyer-Lindenberg, Andreas, Miller, Andrew H., Nemeroff, Charles B., Normann, Claus, Nutt, David, Pallanti, Stefano, Pani, Luca, Penninx, Brenda W.J.H., Schatzberg, Alan F., Shelton, Richard C., Yatham, Lakshmi N., Young, Allan H., Zahn, Roland, Aislaitner, Georgios, Butlen-Ducuing, Florence, Fletcher, Christine, Haberkamp, Marion, Laughren, Thomas, Mäntylä, Fanni Laura, Schruers, Koen, Thomson, Andrew, Arteaga-Henríquez, Gara, Benedetti, Francesco, Cash-Gibson, Lucinda, Chae, Woo Ri, De Smedt, Heidi, Gold, Stefan M., Hoogendijk, Witte J.G., Mondragón, Valeria Jordán, Maron, Eduard, Martynowicz, Jadwiga, Melloni, Elisa, Otte, Christian, Perez-Fuentes, Gabriela, Poletti, Sara, Schmidt, Mark E., van de Ketterij, Edwin, Woo, Katherine, Flossbach, Yanina, Ramos-Quiroga, J. Antoni, Savitz, Adam J., and Pariante, Carmine M.

Abstract

Criteria for treatment-resistant depression (TRD) and partially responsive depression (PRD) as subtypes of major depressive disorder (MDD) are not unequivocally defined. In the present document we used a Delphi-method-based consensus approach to define TRD and PRD and to serve as operational criteria for future clinical studies, especially if conducted for regulatory purposes. We reviewed the literature and brought together a group of international experts (including clinicians, academics, researchers, employees of pharmaceutical companies, regulatory bodies representatives, and one person with lived experience) to evaluate the state-of-the-art and main controversies regarding the current classification. We then provided recommendations on how to design clinical trials, and on how to guide research in unmet needs and knowledge gaps. This report will feed into one of the main objectives of the EUropean Patient-cEntric clinicAl tRial pLatforms, Innovative Medicines Initiative (EU-PEARL, IMI) MDD project, to design a protocol for platform trials of new medications for TRD/PRD.

Published
2022

9. Expert appraisal of criteria for assessing gaming disorder: an international Delphi study

Author

UCL - SSS/IONS/NEUR - Clinical Neuroscience, Castro‐Calvo, Jesús, King, Daniel L., Stein, Dan J., Brand, Matthias, Carmi, Lior, Chamberlain, Samuel R., Demetrovics, Zsolt, Fineberg, Naomi A., Rumpf, Hans‐Jürgen, Yücel, Murat, Achab, Sophia, Ambekar, Atul, Bahar, Norharlina, Blaszczynski, Alexander, Bowden‐Jones, Henrietta, Carbonell, Xavier, Chan, Elda Mei Lo, Ko, Chih‐Hung, Timary, Philippe, Dufour, Magali, Grall‐Bronnec, Marie, Lee, Hae Kook, Higuchi, Susumu, Jimenez‐Murcia, Susana, Király, Orsolya, Kuss, Daria J., Long, Jiang, Müller, Astrid, Pallanti, Stefano, Potenza, Marc N., Rahimi‐Movaghar, Afarin, Saunders, John B., Schimmenti, Adriano, Lee, Seung‐Yup, Siste, Kristiana, Spritzer, Daniel T., Starcevic, Vladan, Weinstein, Aviv M., Wölfling, Klaus, Billieux, Joël, UCL - SSS/IONS/NEUR - Clinical Neuroscience, Castro‐Calvo, Jesús, King, Daniel L., Stein, Dan J., Brand, Matthias, Carmi, Lior, Chamberlain, Samuel R., Demetrovics, Zsolt, Fineberg, Naomi A., Rumpf, Hans‐Jürgen, Yücel, Murat, Achab, Sophia, Ambekar, Atul, Bahar, Norharlina, Blaszczynski, Alexander, Bowden‐Jones, Henrietta, Carbonell, Xavier, Chan, Elda Mei Lo, Ko, Chih‐Hung, Timary, Philippe, Dufour, Magali, Grall‐Bronnec, Marie, Lee, Hae Kook, Higuchi, Susumu, Jimenez‐Murcia, Susana, Király, Orsolya, Kuss, Daria J., Long, Jiang, Müller, Astrid, Pallanti, Stefano, Potenza, Marc N., Rahimi‐Movaghar, Afarin, Saunders, John B., Schimmenti, Adriano, Lee, Seung‐Yup, Siste, Kristiana, Spritzer, Daniel T., Starcevic, Vladan, Weinstein, Aviv M., Wölfling, Klaus, and Billieux, Joël

Published
2021

10. Expert appraisal of criteria for assessing gaming disorder: an international Delphi study.

Author

UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (SLuc) Service de psychiatrie adulte, Castro-Calvo, Jesús, King, Daniel L, Stein, Dan J, Brand, Matthias, Carmi, Lior, Chamberlain, Samuel R, Demetrovics, Zsolt, Fineberg, Naomi A, Rumpf, Hans-Jürgen, Yücel, Murat, Achab, Sophia, Ambekar, Atul, Bahar, Norharlina, Blaszczynski, Alexander, Bowden-Jones, Henrietta, Carbonell, Xavier, Chan, Elda Mei Lo, Ko, Chih-Hung, De Timary, Philippe, Dufour, Magali, Grall-Bronnec, Marie, Lee, Hae Kook, Higuchi, Susumu, Jimenez-Murcia, Susana, Király, Orsolya, Kuss, Daria J, Long, Jiang, Müller, Astrid, Pallanti, Stefano, Potenza, Marc N, Rahimi-Movaghar, Afarin, Saunders, John B, Schimmenti, Adriano, Lee, Seung-Yup, Siste, Kristiana, Spritzer, Daniel T, Starcevic, Vladan, Weinstein, Aviv M, Wölfling, Klaus, Billieux, Joël, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (SLuc) Service de psychiatrie adulte, Castro-Calvo, Jesús, King, Daniel L, Stein, Dan J, Brand, Matthias, Carmi, Lior, Chamberlain, Samuel R, Demetrovics, Zsolt, Fineberg, Naomi A, Rumpf, Hans-Jürgen, Yücel, Murat, Achab, Sophia, Ambekar, Atul, Bahar, Norharlina, Blaszczynski, Alexander, Bowden-Jones, Henrietta, Carbonell, Xavier, Chan, Elda Mei Lo, Ko, Chih-Hung, De Timary, Philippe, Dufour, Magali, Grall-Bronnec, Marie, Lee, Hae Kook, Higuchi, Susumu, Jimenez-Murcia, Susana, Király, Orsolya, Kuss, Daria J, Long, Jiang, Müller, Astrid, Pallanti, Stefano, Potenza, Marc N, Rahimi-Movaghar, Afarin, Saunders, John B, Schimmenti, Adriano, Lee, Seung-Yup, Siste, Kristiana, Spritzer, Daniel T, Starcevic, Vladan, Weinstein, Aviv M, Wölfling, Klaus, and Billieux, Joël

Abstract

Following the recognition of 'internet gaming disorder' (IGD) as a condition requiring further study by the DSM-5, 'gaming disorder' (GD) was officially included as a diagnostic entity by the World Health Organization (WHO) in the 11th revision of the International Classification of Diseases (ICD-11). However, the proposed diagnostic criteria for gaming disorder remain the subject of debate, and there has been no systematic attempt to integrate the views of different groups of experts. To achieve a more systematic agreement on this new disorder, this study employed the Delphi expert consensus method to obtain expert agreement on the diagnostic validity, clinical utility and prognostic value of the DSM-5 criteria and ICD-11 clinical guidelines for GD. A total of 29 international experts with clinical and/or research experience in GD completed three iterative rounds of a Delphi survey. Experts rated proposed criteria in progressive rounds until a pre-determined level of agreement was achieved. For DSM-5 IGD criteria, there was an agreement both that a subset had high diagnostic validity, clinical utility and prognostic value and that some (e.g. tolerance, deception) had low diagnostic validity, clinical utility and prognostic value. Crucially, some DSM-5 criteria (e.g. escapism/mood regulation, tolerance) were regarded as incapable of distinguishing between problematic and non-problematic gaming. In contrast, ICD-11 diagnostic guidelines for GD (except for the criterion relating to diminished non-gaming interests) were judged as presenting high diagnostic validity, clinical utility and prognostic value. This Delphi survey provides a foundation for identifying the most diagnostically valid and clinically useful criteria for GD. There was expert agreement that some DSM-5 criteria were not clinically relevant and may pathologize non-problematic patterns of gaming, whereas ICD-11 diagnostic guidelines are likely to diagnose GD adequately and avoid pathologizing.

Published
2021

17. Clinical advances in obsessive-compulsive disorder: a position statement by the International College of Obsessive-Compulsive Spectrum Disorders

Author

Fineberg, Naomi A, Hollander, Eric, Pallanti, Stefano, Walitza, Susanne, Grünblatt, Edna, Dell'Osso, Bernardo Maria, Albert, Umberto, Geller, Daniel A, Brakoulias, Vlasios, Janardhan Reddy, Y C, Arumugham, Shyam Sundar, Shavitt, Roseli G, Drummond, Lynne, Grancini, Benedetta, De Carlo, Vera, Cinosi, Eduardo, Chamberlain, Samuel R, Ioannidis, Konstantinos, Rodriguez, Carolyn I, Garg, Kabir, Castle, David, Van Ameringen, Michael, Stein, Dan J, Carmi, Lior, Zohar, Joseph, Menchon, Jose M, Fineberg, Naomi A, Hollander, Eric, Pallanti, Stefano, Walitza, Susanne, Grünblatt, Edna, Dell'Osso, Bernardo Maria, Albert, Umberto, Geller, Daniel A, Brakoulias, Vlasios, Janardhan Reddy, Y C, Arumugham, Shyam Sundar, Shavitt, Roseli G, Drummond, Lynne, Grancini, Benedetta, De Carlo, Vera, Cinosi, Eduardo, Chamberlain, Samuel R, Ioannidis, Konstantinos, Rodriguez, Carolyn I, Garg, Kabir, Castle, David, Van Ameringen, Michael, Stein, Dan J, Carmi, Lior, Zohar, Joseph, and Menchon, Jose M

Abstract

In this position statement, developed by The International College of Obsessive-Compulsive Spectrum Disorders, a group of international experts responds to recent developments in the evidence-based management of obsessive-compulsive disorder (OCD). The article presents those selected therapeutic advances judged to be of utmost relevance to the treatment of OCD, based on new and emerging evidence from clinical and translational science. Areas covered include refinement in the methods of clinical assessment, the importance of early intervention based on new staging models and the need to provide sustained well-being involving effective relapse prevention. The relative benefits of psychological, pharmacological and somatic treatments are reviewed and novel treatment strategies for difficult to treat OCD, including neurostimulation, as well as new areas for research such as problematic internet use, novel digital interventions, immunological therapies, pharmacogenetics and novel forms of psychotherapy are discussed.

Published
2020

19. Manifesto for a European research network into Problematic Usage of the Internet

Author

Fineberg, Naomi A., Demetrovics, Zsolt, Stein, Dan J., Loannidis, Konstantinos, Potenza, Marc N., Grünblatt, Edna, Brand, Matthias, Billieux, Joël, Carmi, Lior, King, Daniel Luke, Grant, Jon E., Yücel, Murat, Dell'Osso, Bernardo, Rumpf, Hans-Jürgen, Hall, Natalie, Hollander, Eric, Goudriaan, Anna, Menchon, Jose M, Zohar, Joseph, Burkauskas, Julius, Martinotti, Giovanni, Van Ameringen, Michael, Corazza, Ornella, Pallanti, Stefano, COST ACTION NETWORK, Chamberlain, Samuel Robin, Fineberg, Naomi A., Demetrovics, Zsolt, Stein, Dan J., Loannidis, Konstantinos, Potenza, Marc N., Grünblatt, Edna, Brand, Matthias, Billieux, Joël, Carmi, Lior, King, Daniel Luke, Grant, Jon E., Yücel, Murat, Dell'Osso, Bernardo, Rumpf, Hans-Jürgen, Hall, Natalie, Hollander, Eric, Goudriaan, Anna, Menchon, Jose M, Zohar, Joseph, Burkauskas, Julius, Martinotti, Giovanni, Van Ameringen, Michael, Corazza, Ornella, Pallanti, Stefano, COST ACTION NETWORK, and Chamberlain, Samuel Robin

Abstract

The Internet is now all-pervasive across much of the globe. While it has positive uses (e.g. prompt access to information, rapid news dissemination), many individuals develop Problematic Use of the Internet (PUI), an umbrella term incorporating a range of repetitive impairing behaviours. The Internet can act as a conduit for, and may contribute to, functionally impairing behaviours including excessive and compulsive video gaming, compulsive sexual behaviour, buying, gambling, streaming or social networks use. There is growing public and National health authority concern about the health and societal costs of PUI across the lifespan. Gaming Disorder is being considered for inclusion as a mental disorder in diagnostic classification systems, and was listed in the ICD-11 version released for consideration by Member States ( http://www.who.int/classifications/icd/revision/timeline/en/ ). More research is needed into disorder definitions, validation of clinical tools, prevalence, clinical parameters, brain-based biology, socio-health-economic impact, and empirically validated intervention and policy ap- proaches. Potential cultural differences in the magnitudes and natures of types and patterns of PUI need to be better understood, to inform optimal health policy and service development. To this end, the EU under Horizon 2020 has launched a new four-year European Cooperation in Science and Technology (COST) Action Programme (CA 16207), bringing together scientists and clinicians from across the fields of impulsive, compulsive, and addictive disorders, to advance networked interdisciplinary research into PUI across Europe and beyond, ultimately seeking to inform regulatory policies and clinical practice. This paper describes nine critical and achievable research priorities identified by the Network, needed in order to advance understanding of PUI, with a view towards identifying vulnerable individuals for early intervention. The network shall enable collaborative research

Published
2018

20. Manifesto for a European research network into Problematic Usage of the Internet

Author

Fineberg, Naomi A., Demetrovics, Zsolt, Stein, Dan J., Loannidis, Konstantinos, Potenza, Marc N., Grünblatt, Edna, Brand, Matthias, Billieux, Joël, Carmi, Lior, King, Daniel Luke, Grant, Jon E., Yücel, Murat, Dell'Osso, Bernardo, Rumpf, Hans-Jürgen, Hall, Natalie, Hollander, Eric, Goudriaan, Anna, Menchon, Jose M, Zohar, Joseph, Burkauskas, Julius, Martinotti, Giovanni, Van Ameringen, Michael, Corazza, Ornella, Pallanti, Stefano, COST ACTION NETWORK, Chamberlain, Samuel Robin, Fineberg, Naomi A., Demetrovics, Zsolt, Stein, Dan J., Loannidis, Konstantinos, Potenza, Marc N., Grünblatt, Edna, Brand, Matthias, Billieux, Joël, Carmi, Lior, King, Daniel Luke, Grant, Jon E., Yücel, Murat, Dell'Osso, Bernardo, Rumpf, Hans-Jürgen, Hall, Natalie, Hollander, Eric, Goudriaan, Anna, Menchon, Jose M, Zohar, Joseph, Burkauskas, Julius, Martinotti, Giovanni, Van Ameringen, Michael, Corazza, Ornella, Pallanti, Stefano, COST ACTION NETWORK, and Chamberlain, Samuel Robin

Abstract

The Internet is now all-pervasive across much of the globe. While it has positive uses (e.g. prompt access to information, rapid news dissemination), many individuals develop Problematic Use of the Internet (PUI), an umbrella term incorporating a range of repetitive impairing behaviours. The Internet can act as a conduit for, and may contribute to, functionally impairing behaviours including excessive and compulsive video gaming, compulsive sexual behaviour, buying, gambling, streaming or social networks use. There is growing public and National health authority concern about the health and societal costs of PUI across the lifespan. Gaming Disorder is being considered for inclusion as a mental disorder in diagnostic classification systems, and was listed in the ICD-11 version released for consideration by Member States ( http://www.who.int/classifications/icd/revision/timeline/en/ ). More research is needed into disorder definitions, validation of clinical tools, prevalence, clinical parameters, brain-based biology, socio-health-economic impact, and empirically validated intervention and policy ap- proaches. Potential cultural differences in the magnitudes and natures of types and patterns of PUI need to be better understood, to inform optimal health policy and service development. To this end, the EU under Horizon 2020 has launched a new four-year European Cooperation in Science and Technology (COST) Action Programme (CA 16207), bringing together scientists and clinicians from across the fields of impulsive, compulsive, and addictive disorders, to advance networked interdisciplinary research into PUI across Europe and beyond, ultimately seeking to inform regulatory policies and clinical practice. This paper describes nine critical and achievable research priorities identified by the Network, needed in order to advance understanding of PUI, with a view towards identifying vulnerable individuals for early intervention. The network shall enable collaborative research

Published
2018

21. Transcranial magnetic stimulation in the treatment of obsessive–compulsive disorder: current perspectives

Author

Lusicic,Ana, Schruers,Koen RJ, Pallanti,Stefano, Castle,David J, Lusicic,Ana, Schruers,Koen RJ, Pallanti,Stefano, and Castle,David J

Abstract

Ana Lusicic,1 Koen RJ Schruers,2 Stefano Pallanti,3,4 David J Castle5,6 1PACE Clinic, Orygen Youth Health, Melbourne, VIC, Australia; 2Research Institute for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands; 3Institute of Neurosciences, Florence, Italy; 4Stanford University, Palo Alto, CA, USA; 5St Vincent’s Hospital, 6University of Melbourne, Melbourne, VIC, Australia Abstract: Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive neurostimulation technique receiving increasing attention in the treatment of different psychiatric disorders. Evidence for rTMS use in obsessive–compulsive disorder (OCD) is accumulating and informing further developments in the neurostimulation field, the latest being deep transcranial magnetic stimulation (dTMS). dTMS allows direct stimulation of deeper subcortical structures and larger brain volume than conventional rTMS. Underlying neurobiological mechanisms related to transcranial magnetic stimulation are still under evaluation, but appear to offer a novel “third” way of addressing symptoms via localized electrical stimulation compared to pharmacotherapy and psychotherapy approaches. This systematic review focuses on the effects of rTMS and dTMS stimulation on different brain targets in OCD. Brain areas included are the dorsolateral prefrontal cortex, supplementary motor area, orbitofrontal cortex/medial prefrontal cortex, and anterior cingulate cortex (ACC). Improved understanding of the therapeutic effects of rTMS in OCD will support fine-tuning of the method and help determine how we can best optimize the approach via rTMS or dTMS to achieve clinically relevant results. Keywords: repetitive transcranial magnetic stimulation, rTMS, deep TMS, obsessive–compulsive disorder, OCD, noninvasive neurostimulation

Published
2018

22. Standards of care for obsessive-compulsive disorder centres

Author

Menchón, José M, van Ameringen, Michael, Dell'Osso, Bernardo, Denys, Damiaan, Figee, Martijn, Grant, Jon E, Hollander, Eric, Marazziti, Donatella, Nicolini, Humberto, Pallanti, Stefano, Ruck, Christian, Shavitt, Roseli, Stein, Dan J, Andersson, Erik, Bipeta, Rajshekhar, Cath, Danielle C, Drummond, Lynne, Feusner, Jamie, Geller, Daniel A, Hranov, Georgi, Lochner, Christine, Matsunaga, Hisato, McCabe, Randy E, Mpavaenda, Davis, Nakamae, Takashi, O'Kearney, Richard, Pasquini, Massimo, Pérez Rivera, Ricardo, Poyurovsky, Michael, Real, Eva, do Rosário, Maria Conceição, Soreni, Noam, Swinson, Richard P, Vulink, Nienke, Zohar, Joseph, Fineberg, Naomi, Menchón, José M, van Ameringen, Michael, Dell'Osso, Bernardo, Denys, Damiaan, Figee, Martijn, Grant, Jon E, Hollander, Eric, Marazziti, Donatella, Nicolini, Humberto, Pallanti, Stefano, Ruck, Christian, Shavitt, Roseli, Stein, Dan J, Andersson, Erik, Bipeta, Rajshekhar, Cath, Danielle C, Drummond, Lynne, Feusner, Jamie, Geller, Daniel A, Hranov, Georgi, Lochner, Christine, Matsunaga, Hisato, McCabe, Randy E, Mpavaenda, Davis, Nakamae, Takashi, O'Kearney, Richard, Pasquini, Massimo, Pérez Rivera, Ricardo, Poyurovsky, Michael, Real, Eva, do Rosário, Maria Conceição, Soreni, Noam, Swinson, Richard P, Vulink, Nienke, Zohar, Joseph, and Fineberg, Naomi

Abstract

In recent years, many assessment and care units for obsessive-compulsive disorder (OCD) have been set up in order to detect, diagnose and to properly manage this complex disorder, but there is no consensus regarding the key functions that these units should perform. The International College of Obsessive-Compulsive Spectrum Disorders (ICOCS) together with the Obsessive Compulsive and Related Disorders Network (OCRN) of the European College of Neuropsychopharmacology (ECNP) and the Anxiety and Obsessive Compulsive Disorders Section of the World Psychiaric Association (WPA) has developed a standards of care programme for OCD centres. The goals of this collaborative initiative are promoting basic standards, improving the quality of clinical care and enhance the validity and reliability of research results provided by different facilities and countries.

Published
2016

23. New treatment models for compulsive disorders

Author

Grant, Jon E, Fineberg, Naomi, van Ameringen, Michael, Cath, Danielle, Visser, Henny, Carmi, Lior, Pallanti, Stefano, Hollander, Eric, van Balkom, Anton J L M, Grant, Jon E, Fineberg, Naomi, van Ameringen, Michael, Cath, Danielle, Visser, Henny, Carmi, Lior, Pallanti, Stefano, Hollander, Eric, and van Balkom, Anton J L M

Abstract

Obsessive compulsive disorder (OCD) as well as related disorders such as body dysmorphic disorder, tic disorder, and trichotillomania are all common and often debilitating. Although treatments are available, more effective approaches to these problems are needed. Thus this review article presents what is currently known about OCD and related disorders and suggests that understanding OCD more broadly as a compulsive disorder may allow for more effective treatment options. Toward that goal, the review presents new models of psychopharmacology and psychotherapy, as well as new brain stimulation strategies. Treatment advances, grounded in the neuroscience, have promise in advancing treatment response for OCD as well as other disorders of compulsivity.

Published
2016

24. Standards of care for obsessive-compulsive disorder centres

Author

Menchón, José M, van Ameringen, Michael, Dell'Osso, Bernardo, Denys, D., Figee, Martijn, Grant, Jon E, Hollander, Eric, Marazziti, Donatella, Nicolini, Humberto, Pallanti, Stefano, Ruck, Christian, Shavitt, Roseli, Stein, Dan J, Andersson, Erik, Bipeta, Rajshekhar, Cath, Danielle C, Drummond, Lynne, Feusner, Jamie, Geller, Daniel A, Hranov, Georgi, Lochner, Christine, Matsunaga, Hisato, McCabe, Randy E, Mpavaenda, Davis, Nakamae, Takashi, O'Kearney, Richard, Pasquini, Massimo, Pérez Rivera, Ricardo, Poyurovsky, Michael, Real, Eva, do Rosário, Maria Conceição, Soreni, Noam, Swinson, Richard P, Vulink, Nienke, Zohar, Joseph, Fineberg, Naomi, Menchón, José M, van Ameringen, Michael, Dell'Osso, Bernardo, Denys, D., Figee, Martijn, Grant, Jon E, Hollander, Eric, Marazziti, Donatella, Nicolini, Humberto, Pallanti, Stefano, Ruck, Christian, Shavitt, Roseli, Stein, Dan J, Andersson, Erik, Bipeta, Rajshekhar, Cath, Danielle C, Drummond, Lynne, Feusner, Jamie, Geller, Daniel A, Hranov, Georgi, Lochner, Christine, Matsunaga, Hisato, McCabe, Randy E, Mpavaenda, Davis, Nakamae, Takashi, O'Kearney, Richard, Pasquini, Massimo, Pérez Rivera, Ricardo, Poyurovsky, Michael, Real, Eva, do Rosário, Maria Conceição, Soreni, Noam, Swinson, Richard P, Vulink, Nienke, Zohar, Joseph, and Fineberg, Naomi

Abstract

In recent years, many assessment and care units for obsessive-compulsive disorder (OCD) have been set up in order to detect, diagnose and to properly manage this complex disorder, but there is no consensus regarding the key functions that these units should perform. The International College of Obsessive-Compulsive Spectrum Disorders (ICOCS) together with the Obsessive Compulsive and Related Disorders Network (OCRN) of the European College of Neuropsychopharmacology (ECNP) and the Anxiety and Obsessive Compulsive Disorders Section of the World Psychiaric Association (WPA) has developed a standards of care programme for OCD centres. The goals of this collaborative initiative are promoting basic standards, improving the quality of clinical care and enhance the validity and reliability of research results provided by different facilities and countries.

Published
2016

25. Standards of care for obsessive-compulsive disorder centres

Author

Menchón, José M, van Ameringen, Michael, Dell'Osso, Bernardo, Denys, D., Figee, Martijn, Grant, Jon E, Hollander, Eric, Marazziti, Donatella, Nicolini, Humberto, Pallanti, Stefano, Ruck, Christian, Shavitt, Roseli, Stein, Dan J, Andersson, Erik, Bipeta, Rajshekhar, Cath, Danielle C, Drummond, Lynne, Feusner, Jamie, Geller, Daniel A, Hranov, Georgi, Lochner, Christine, Matsunaga, Hisato, McCabe, Randy E, Mpavaenda, Davis, Nakamae, Takashi, O'Kearney, Richard, Pasquini, Massimo, Pérez Rivera, Ricardo, Poyurovsky, Michael, Real, Eva, do Rosário, Maria Conceição, Soreni, Noam, Swinson, Richard P, Vulink, Nienke, Zohar, Joseph, Fineberg, Naomi, Menchón, José M, van Ameringen, Michael, Dell'Osso, Bernardo, Denys, D., Figee, Martijn, Grant, Jon E, Hollander, Eric, Marazziti, Donatella, Nicolini, Humberto, Pallanti, Stefano, Ruck, Christian, Shavitt, Roseli, Stein, Dan J, Andersson, Erik, Bipeta, Rajshekhar, Cath, Danielle C, Drummond, Lynne, Feusner, Jamie, Geller, Daniel A, Hranov, Georgi, Lochner, Christine, Matsunaga, Hisato, McCabe, Randy E, Mpavaenda, Davis, Nakamae, Takashi, O'Kearney, Richard, Pasquini, Massimo, Pérez Rivera, Ricardo, Poyurovsky, Michael, Real, Eva, do Rosário, Maria Conceição, Soreni, Noam, Swinson, Richard P, Vulink, Nienke, Zohar, Joseph, and Fineberg, Naomi

Abstract

In recent years, many assessment and care units for obsessive-compulsive disorder (OCD) have been set up in order to detect, diagnose and to properly manage this complex disorder, but there is no consensus regarding the key functions that these units should perform. The International College of Obsessive-Compulsive Spectrum Disorders (ICOCS) together with the Obsessive Compulsive and Related Disorders Network (OCRN) of the European College of Neuropsychopharmacology (ECNP) and the Anxiety and Obsessive Compulsive Disorders Section of the World Psychiaric Association (WPA) has developed a standards of care programme for OCD centres. The goals of this collaborative initiative are promoting basic standards, improving the quality of clinical care and enhance the validity and reliability of research results provided by different facilities and countries.

Published
2016

26. Standards of care for obsessive-compulsive disorder centres

Author

Leerstoel Hout, Experimental psychopathology, Menchón, José M, van Ameringen, Michael, Dell'Osso, Bernardo, Denys, Damiaan, Figee, Martijn, Grant, Jon E, Hollander, Eric, Marazziti, Donatella, Nicolini, Humberto, Pallanti, Stefano, Ruck, Christian, Shavitt, Roseli, Stein, Dan J, Andersson, Erik, Bipeta, Rajshekhar, Cath, Danielle C, Drummond, Lynne, Feusner, Jamie, Geller, Daniel A, Hranov, Georgi, Lochner, Christine, Matsunaga, Hisato, McCabe, Randy E, Mpavaenda, Davis, Nakamae, Takashi, O'Kearney, Richard, Pasquini, Massimo, Pérez Rivera, Ricardo, Poyurovsky, Michael, Real, Eva, do Rosário, Maria Conceição, Soreni, Noam, Swinson, Richard P, Vulink, Nienke, Zohar, Joseph, Fineberg, Naomi, Leerstoel Hout, Experimental psychopathology, Menchón, José M, van Ameringen, Michael, Dell'Osso, Bernardo, Denys, Damiaan, Figee, Martijn, Grant, Jon E, Hollander, Eric, Marazziti, Donatella, Nicolini, Humberto, Pallanti, Stefano, Ruck, Christian, Shavitt, Roseli, Stein, Dan J, Andersson, Erik, Bipeta, Rajshekhar, Cath, Danielle C, Drummond, Lynne, Feusner, Jamie, Geller, Daniel A, Hranov, Georgi, Lochner, Christine, Matsunaga, Hisato, McCabe, Randy E, Mpavaenda, Davis, Nakamae, Takashi, O'Kearney, Richard, Pasquini, Massimo, Pérez Rivera, Ricardo, Poyurovsky, Michael, Real, Eva, do Rosário, Maria Conceição, Soreni, Noam, Swinson, Richard P, Vulink, Nienke, Zohar, Joseph, and Fineberg, Naomi

Published
2016

27. New treatment models for compulsive disorders

Author

Leerstoel Hout, Experimental psychopathology, Grant, Jon E, Fineberg, Naomi, van Ameringen, Michael, Cath, Danielle, Visser, Henny, Carmi, Lior, Pallanti, Stefano, Hollander, Eric, van Balkom, Anton J L M, Leerstoel Hout, Experimental psychopathology, Grant, Jon E, Fineberg, Naomi, van Ameringen, Michael, Cath, Danielle, Visser, Henny, Carmi, Lior, Pallanti, Stefano, Hollander, Eric, and van Balkom, Anton J L M

Published
2016

28. Standards of care for obsessive-compulsive disorder centres

Author

Leerstoel Hout, Experimental psychopathology, Menchón, José M, van Ameringen, Michael, Dell'Osso, Bernardo, Denys, Damiaan, Figee, Martijn, Grant, Jon E, Hollander, Eric, Marazziti, Donatella, Nicolini, Humberto, Pallanti, Stefano, Ruck, Christian, Shavitt, Roseli, Stein, Dan J, Andersson, Erik, Bipeta, Rajshekhar, Cath, Danielle C, Drummond, Lynne, Feusner, Jamie, Geller, Daniel A, Hranov, Georgi, Lochner, Christine, Matsunaga, Hisato, McCabe, Randy E, Mpavaenda, Davis, Nakamae, Takashi, O'Kearney, Richard, Pasquini, Massimo, Pérez Rivera, Ricardo, Poyurovsky, Michael, Real, Eva, do Rosário, Maria Conceição, Soreni, Noam, Swinson, Richard P, Vulink, Nienke, Zohar, Joseph, Fineberg, Naomi, Leerstoel Hout, Experimental psychopathology, Menchón, José M, van Ameringen, Michael, Dell'Osso, Bernardo, Denys, Damiaan, Figee, Martijn, Grant, Jon E, Hollander, Eric, Marazziti, Donatella, Nicolini, Humberto, Pallanti, Stefano, Ruck, Christian, Shavitt, Roseli, Stein, Dan J, Andersson, Erik, Bipeta, Rajshekhar, Cath, Danielle C, Drummond, Lynne, Feusner, Jamie, Geller, Daniel A, Hranov, Georgi, Lochner, Christine, Matsunaga, Hisato, McCabe, Randy E, Mpavaenda, Davis, Nakamae, Takashi, O'Kearney, Richard, Pasquini, Massimo, Pérez Rivera, Ricardo, Poyurovsky, Michael, Real, Eva, do Rosário, Maria Conceição, Soreni, Noam, Swinson, Richard P, Vulink, Nienke, Zohar, Joseph, and Fineberg, Naomi

Published
2016

29. New treatment models for compulsive disorders

Author

Leerstoel Hout, Experimental psychopathology, Grant, Jon E, Fineberg, Naomi, van Ameringen, Michael, Cath, Danielle, Visser, Henny, Carmi, Lior, Pallanti, Stefano, Hollander, Eric, van Balkom, Anton J L M, Leerstoel Hout, Experimental psychopathology, Grant, Jon E, Fineberg, Naomi, van Ameringen, Michael, Cath, Danielle, Visser, Henny, Carmi, Lior, Pallanti, Stefano, Hollander, Eric, and van Balkom, Anton J L M

Published
2016

30. Standards of care for obsessive-compulsive disorder centres

Author

Leerstoel Hout, Experimental psychopathology, Menchón, José M, van Ameringen, Michael, Dell'Osso, Bernardo, Denys, Damiaan, Figee, Martijn, Grant, Jon E, Hollander, Eric, Marazziti, Donatella, Nicolini, Humberto, Pallanti, Stefano, Ruck, Christian, Shavitt, Roseli, Stein, Dan J, Andersson, Erik, Bipeta, Rajshekhar, Cath, Danielle C, Drummond, Lynne, Feusner, Jamie, Geller, Daniel A, Hranov, Georgi, Lochner, Christine, Matsunaga, Hisato, McCabe, Randy E, Mpavaenda, Davis, Nakamae, Takashi, O'Kearney, Richard, Pasquini, Massimo, Pérez Rivera, Ricardo, Poyurovsky, Michael, Real, Eva, do Rosário, Maria Conceição, Soreni, Noam, Swinson, Richard P, Vulink, Nienke, Zohar, Joseph, Fineberg, Naomi, Leerstoel Hout, Experimental psychopathology, Menchón, José M, van Ameringen, Michael, Dell'Osso, Bernardo, Denys, Damiaan, Figee, Martijn, Grant, Jon E, Hollander, Eric, Marazziti, Donatella, Nicolini, Humberto, Pallanti, Stefano, Ruck, Christian, Shavitt, Roseli, Stein, Dan J, Andersson, Erik, Bipeta, Rajshekhar, Cath, Danielle C, Drummond, Lynne, Feusner, Jamie, Geller, Daniel A, Hranov, Georgi, Lochner, Christine, Matsunaga, Hisato, McCabe, Randy E, Mpavaenda, Davis, Nakamae, Takashi, O'Kearney, Richard, Pasquini, Massimo, Pérez Rivera, Ricardo, Poyurovsky, Michael, Real, Eva, do Rosário, Maria Conceição, Soreni, Noam, Swinson, Richard P, Vulink, Nienke, Zohar, Joseph, and Fineberg, Naomi

Published
2016

31. New treatment models for compulsive disorders

Author

Leerstoel Hout, Experimental psychopathology, Grant, Jon E, Fineberg, Naomi, van Ameringen, Michael, Cath, Danielle, Visser, Henny, Carmi, Lior, Pallanti, Stefano, Hollander, Eric, van Balkom, Anton J L M, Leerstoel Hout, Experimental psychopathology, Grant, Jon E, Fineberg, Naomi, van Ameringen, Michael, Cath, Danielle, Visser, Henny, Carmi, Lior, Pallanti, Stefano, Hollander, Eric, and van Balkom, Anton J L M

Published
2016

32. Standards of care for obsessive-compulsive disorder centres

Author

Menchón, José M, van Ameringen, Michael, Dell'Osso, Bernardo, Denys, D., Figee, Martijn, Grant, Jon E, Hollander, Eric, Marazziti, Donatella, Nicolini, Humberto, Pallanti, Stefano, Ruck, Christian, Shavitt, Roseli, Stein, Dan J, Andersson, Erik, Bipeta, Rajshekhar, Cath, Danielle C, Drummond, Lynne, Feusner, Jamie, Geller, Daniel A, Hranov, Georgi, Lochner, Christine, Matsunaga, Hisato, McCabe, Randy E, Mpavaenda, Davis, Nakamae, Takashi, O'Kearney, Richard, Pasquini, Massimo, Pérez Rivera, Ricardo, Poyurovsky, Michael, Real, Eva, do Rosário, Maria Conceição, Soreni, Noam, Swinson, Richard P, Vulink, Nienke, Zohar, Joseph, Fineberg, Naomi, Menchón, José M, van Ameringen, Michael, Dell'Osso, Bernardo, Denys, D., Figee, Martijn, Grant, Jon E, Hollander, Eric, Marazziti, Donatella, Nicolini, Humberto, Pallanti, Stefano, Ruck, Christian, Shavitt, Roseli, Stein, Dan J, Andersson, Erik, Bipeta, Rajshekhar, Cath, Danielle C, Drummond, Lynne, Feusner, Jamie, Geller, Daniel A, Hranov, Georgi, Lochner, Christine, Matsunaga, Hisato, McCabe, Randy E, Mpavaenda, Davis, Nakamae, Takashi, O'Kearney, Richard, Pasquini, Massimo, Pérez Rivera, Ricardo, Poyurovsky, Michael, Real, Eva, do Rosário, Maria Conceição, Soreni, Noam, Swinson, Richard P, Vulink, Nienke, Zohar, Joseph, and Fineberg, Naomi

Abstract

In recent years, many assessment and care units for obsessive-compulsive disorder (OCD) have been set up in order to detect, diagnose and to properly manage this complex disorder, but there is no consensus regarding the key functions that these units should perform. The International College of Obsessive-Compulsive Spectrum Disorders (ICOCS) together with the Obsessive Compulsive and Related Disorders Network (OCRN) of the European College of Neuropsychopharmacology (ECNP) and the Anxiety and Obsessive Compulsive Disorders Section of the World Psychiaric Association (WPA) has developed a standards of care programme for OCD centres. The goals of this collaborative initiative are promoting basic standards, improving the quality of clinical care and enhance the validity and reliability of research results provided by different facilities and countries.

Published
2016

33. Comorbidity in obsessive-compulsive disorder (OCD): a report from the International College of Obsessive-Compulsive Spectrum Disorders (ICOCS)

Author

Lochner, Christine, Fineberg, Naomi A, Zohar, Joseph, van Ameringen, Michael, Juven-Wetzler, Alzbeta, Altamura, Alfredo Carlo, Cuzen, Natalie L, Hollander, Eric, Denys, D., Nicolini, Humberto, Dell'Osso, Bernardo, Pallanti, Stefano, Stein, Dan J, Lochner, Christine, Fineberg, Naomi A, Zohar, Joseph, van Ameringen, Michael, Juven-Wetzler, Alzbeta, Altamura, Alfredo Carlo, Cuzen, Natalie L, Hollander, Eric, Denys, D., Nicolini, Humberto, Dell'Osso, Bernardo, Pallanti, Stefano, and Stein, Dan J

Abstract

BACKGROUND: Obsessive-compulsive disorder (OCD) is often associated with significant psychiatric comorbidity. Comorbid disorders include mood and anxiety disorders as well as obsessive-compulsive spectrum disorders (OCSDs). This paper aims to investigate comorbidity of DSM Axis I-disorders, including OCSDs, in patients with OCD from 10 centers affiliated with the International College of Obsessive-Compulsive Spectrum Disorders (ICOCS).METHODS: This is a cross-sectional study of comorbidity of Axis I disorders including OCSDs in 457 outpatients with primary OCD (37% male; 63% female), with ages ranging from 12 to 88years (mean: 39.8±13). Treating clinicians assessed Axis I disorders using the Mini International Neuropsychiatric Interview and assessed OCSDs using the Structured Clinical Interview for OCD related/spectrum disorders (SCID-OCSD).RESULTS: In terms of the OCSDs, highest comorbidity rates were found for tic disorder (12.5%), BDD (8.71%) and self-injurious behavior (7.43%). In terms of the other Axis I-disorders, major depressive disorder (MDD; 15%), social anxiety disorder (SAD; 14%), generalized anxiety disorder (GAD; 13%) and dysthymic disorder (13%) were most prevalent.DISCUSSION: High comorbidity of some OCSDs in OCD supports the formal recognition of these conditions in a separate chapter of the nosology. Rates of other Axis I disorders are high in both the general population and in OCSDs, indicating that these may often also need to be the focus of intervention in OCD.

Published
2014

34. Comorbidity in obsessive-compulsive disorder (OCD): a report from the International College of Obsessive-Compulsive Spectrum Disorders (ICOCS)

Author

Lochner, Christine, Fineberg, Naomi A, Zohar, Joseph, van Ameringen, Michael, Juven-Wetzler, Alzbeta, Altamura, Alfredo Carlo, Cuzen, Natalie L, Hollander, Eric, Denys, D., Nicolini, Humberto, Dell'Osso, Bernardo, Pallanti, Stefano, Stein, Dan J, Lochner, Christine, Fineberg, Naomi A, Zohar, Joseph, van Ameringen, Michael, Juven-Wetzler, Alzbeta, Altamura, Alfredo Carlo, Cuzen, Natalie L, Hollander, Eric, Denys, D., Nicolini, Humberto, Dell'Osso, Bernardo, Pallanti, Stefano, and Stein, Dan J

Abstract

BACKGROUND: Obsessive-compulsive disorder (OCD) is often associated with significant psychiatric comorbidity. Comorbid disorders include mood and anxiety disorders as well as obsessive-compulsive spectrum disorders (OCSDs). This paper aims to investigate comorbidity of DSM Axis I-disorders, including OCSDs, in patients with OCD from 10 centers affiliated with the International College of Obsessive-Compulsive Spectrum Disorders (ICOCS).METHODS: This is a cross-sectional study of comorbidity of Axis I disorders including OCSDs in 457 outpatients with primary OCD (37% male; 63% female), with ages ranging from 12 to 88years (mean: 39.8±13). Treating clinicians assessed Axis I disorders using the Mini International Neuropsychiatric Interview and assessed OCSDs using the Structured Clinical Interview for OCD related/spectrum disorders (SCID-OCSD).RESULTS: In terms of the OCSDs, highest comorbidity rates were found for tic disorder (12.5%), BDD (8.71%) and self-injurious behavior (7.43%). In terms of the other Axis I-disorders, major depressive disorder (MDD; 15%), social anxiety disorder (SAD; 14%), generalized anxiety disorder (GAD; 13%) and dysthymic disorder (13%) were most prevalent.DISCUSSION: High comorbidity of some OCSDs in OCD supports the formal recognition of these conditions in a separate chapter of the nosology. Rates of other Axis I disorders are high in both the general population and in OCSDs, indicating that these may often also need to be the focus of intervention in OCD.

Published
2014

37. European consensus statement on diagnosis and treatment of adult ADHD : The European Network Adult ADHD

Author

Kooij, Sandra JJ, Bejerot, Susanne, Blackwell, Andrew, Caci, Herve, Casas-Brugué, Miquel, Carpentier, Pieter J, Edvinsson, Dan, Fayyad, John, Foeken, Karin, Fitzgerald, Michael, Gaillac, Veronique, Ginsberg, Ylva, Henry, Chantal, Krause, Johanna, Lensing, Michael B, Manor, Iris, Niederhofer, Helmut, Nunes-Filipe, Carlos, Ohlmeier, Martin D, Oswald, Pierre, Pallanti, Stefano, Pehlivanidis, Artemios, Ramos-Quiroga, Josep A, Rastam, Maria, Ryffel-Rawak, Doris, Stes, Steven, Asherson, Philip, Kooij, Sandra JJ, Bejerot, Susanne, Blackwell, Andrew, Caci, Herve, Casas-Brugué, Miquel, Carpentier, Pieter J, Edvinsson, Dan, Fayyad, John, Foeken, Karin, Fitzgerald, Michael, Gaillac, Veronique, Ginsberg, Ylva, Henry, Chantal, Krause, Johanna, Lensing, Michael B, Manor, Iris, Niederhofer, Helmut, Nunes-Filipe, Carlos, Ohlmeier, Martin D, Oswald, Pierre, Pallanti, Stefano, Pehlivanidis, Artemios, Ramos-Quiroga, Josep A, Rastam, Maria, Ryffel-Rawak, Doris, Stes, Steven, and Asherson, Philip

Abstract

BACKGROUND: Attention deficit hyperactivity disorder (ADHD) is among the most common psychiatric disorders of childhood that persists into adulthood in the majority of cases. The evidence on persistence poses several difficulties for adult psychiatry considering the lack of expertise for diagnostic assessment, limited treatment options and patient facilities across Europe. METHODS: The European Network Adult ADHD, founded in 2003, aims to increase awareness of this disorder and improve knowledge and patient care for adults with ADHD across Europe. This Consensus Statement is one of the actions taken by the European Network Adult ADHD in order to support the clinician with research evidence and clinical experience from 18 European countries in which ADHD in adults is recognised and treated. RESULTS: Besides information on the genetics and neurobiology of ADHD, three major questions are addressed in this statement: (1) What is the clinical picture of ADHD in adults? (2) How can ADHD in adults be properly diagnosed? (3) How should ADHD in adults be effectively treated? CONCLUSIONS: ADHD often presents as an impairing lifelong condition in adults, yet it is currently underdiagnosed and treated in many European countries, leading to ineffective treatment and higher costs of illness. Expertise in diagnostic assessment and treatment of ADHD in adults must increase in psychiatry. Instruments for screening and diagnosis of ADHD in adults are available and appropriate treatments exist, although more research is needed in this age group.

Published
2010
Full Text
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38. European consensus statement on diagnosis and treatment of adult ADHD : The European Network Adult ADHD

Author

Kooij, Sandra JJ, Bejerot, Susanne, Blackwell, Andrew, Caci, Herve, Casas-Brugué, Miquel, Carpentier, Pieter J, Edvinsson, Dan, Fayyad, John, Foeken, Karin, Fitzgerald, Michael, Gaillac, Veronique, Ginsberg, Ylva, Henry, Chantal, Krause, Johanna, Lensing, Michael B, Manor, Iris, Niederhofer, Helmut, Nunes-Filipe, Carlos, Ohlmeier, Martin D, Oswald, Pierre, Pallanti, Stefano, Pehlivanidis, Artemios, Ramos-Quiroga, Josep A, Rastam, Maria, Ryffel-Rawak, Doris, Stes, Steven, Asherson, Philip, Kooij, Sandra JJ, Bejerot, Susanne, Blackwell, Andrew, Caci, Herve, Casas-Brugué, Miquel, Carpentier, Pieter J, Edvinsson, Dan, Fayyad, John, Foeken, Karin, Fitzgerald, Michael, Gaillac, Veronique, Ginsberg, Ylva, Henry, Chantal, Krause, Johanna, Lensing, Michael B, Manor, Iris, Niederhofer, Helmut, Nunes-Filipe, Carlos, Ohlmeier, Martin D, Oswald, Pierre, Pallanti, Stefano, Pehlivanidis, Artemios, Ramos-Quiroga, Josep A, Rastam, Maria, Ryffel-Rawak, Doris, Stes, Steven, and Asherson, Philip

Abstract

BACKGROUND: Attention deficit hyperactivity disorder (ADHD) is among the most common psychiatric disorders of childhood that persists into adulthood in the majority of cases. The evidence on persistence poses several difficulties for adult psychiatry considering the lack of expertise for diagnostic assessment, limited treatment options and patient facilities across Europe. METHODS: The European Network Adult ADHD, founded in 2003, aims to increase awareness of this disorder and improve knowledge and patient care for adults with ADHD across Europe. This Consensus Statement is one of the actions taken by the European Network Adult ADHD in order to support the clinician with research evidence and clinical experience from 18 European countries in which ADHD in adults is recognised and treated. RESULTS: Besides information on the genetics and neurobiology of ADHD, three major questions are addressed in this statement: (1) What is the clinical picture of ADHD in adults? (2) How can ADHD in adults be properly diagnosed? (3) How should ADHD in adults be effectively treated? CONCLUSIONS: ADHD often presents as an impairing lifelong condition in adults, yet it is currently underdiagnosed and treated in many European countries, leading to ineffective treatment and higher costs of illness. Expertise in diagnostic assessment and treatment of ADHD in adults must increase in psychiatry. Instruments for screening and diagnosis of ADHD in adults are available and appropriate treatments exist, although more research is needed in this age group.

Published
2010
Full Text
View/download PDF

39. European consensus statement on diagnosis and treatment of adult ADHD: The European Network Adult ADHD

Author

Kooij, Sandra J J, Bejerot, Susanne, Blackwell, Andrew, Caci, Herve, Casas-Brugué, Miquel, Carpentier, Pieter Jan, Edvinsson, Dan, Fayyad, John, Foeken, Karin, Fitzgerald, Michael, Gaillac, Veronique, Ginsberg, Ylva, Henry, Chantal, Krause, Johanna, Lensing, Michael M.B., Manor, Iris, Niederhofer, Helmut, Nunes-Filipe, Carlos, Ohlmeier, Martin Detlef, Oswald, Pierre, Pallanti, Stefano, Pehlivanidis, Artemios, Ramos-Quiroga, Josep Antoni, Rastam, Maria, Ryffel-Rawak, Doris, Stes, Steven, Asherson, Philip, Kooij, Sandra J J, Bejerot, Susanne, Blackwell, Andrew, Caci, Herve, Casas-Brugué, Miquel, Carpentier, Pieter Jan, Edvinsson, Dan, Fayyad, John, Foeken, Karin, Fitzgerald, Michael, Gaillac, Veronique, Ginsberg, Ylva, Henry, Chantal, Krause, Johanna, Lensing, Michael M.B., Manor, Iris, Niederhofer, Helmut, Nunes-Filipe, Carlos, Ohlmeier, Martin Detlef, Oswald, Pierre, Pallanti, Stefano, Pehlivanidis, Artemios, Ramos-Quiroga, Josep Antoni, Rastam, Maria, Ryffel-Rawak, Doris, Stes, Steven, and Asherson, Philip

Abstract

Background: Attention deficit hyperactivity disorder (ADHD) is among the most common psychiatric disorders of childhood that persists into adulthood in the majority of cases. The evidence on persistence poses several difficulties for adult psychiatry considering the lack of expertise for diagnostic assessment, limited treatment options and patient facilities across Europe.Methods: The European Network Adult ADHD, founded in 2003, aims to increase awareness of this disorder and improve knowledge and patient care for adults with ADHD across Europe. This Consensus Statement is one of the actions taken by the European Network Adult ADHD in order to support the clinician with research evidence and clinical experience from 18 European countries in which ADHD in adults is recognised and treated.Results: Besides information on the genetics and neurobiology of ADHD, three major questions are addressed in this statement: (1) What is the clinical picture of ADHD in adults? (2) How can ADHD in adults be properly diagnosed? (3) How should ADHD in adults be effectively treated?Conclusions: ADHD often presents as an impairing lifelong condition in adults, yet it is currently underdiagnosed and treated in many European countries, leading to ineffective treatment and higher costs of illness. Expertise in diagnostic assessment and treatment of ADHD in adults must increase in psychiatry. Instruments for screening and diagnosis of ADHD in adults are available and appropriate treatments exist, although more research is needed in this age group. © 2010 Kooij et al; licensee BioMed Central Ltd., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2010

40. European consensus statement on diagnosis and treatment of adult ADHD : The European Network Adult ADHD

Author

Kooij, Sandra JJ, Bejerot, Susanne, Blackwell, Andrew, Caci, Herve, Casas-Brugué, Miquel, Carpentier, Pieter J, Edvinsson, Dan, Fayyad, John, Foeken, Karin, Fitzgerald, Michael, Gaillac, Veronique, Ginsberg, Ylva, Henry, Chantal, Krause, Johanna, Lensing, Michael B, Manor, Iris, Niederhofer, Helmut, Nunes-Filipe, Carlos, Ohlmeier, Martin D, Oswald, Pierre, Pallanti, Stefano, Pehlivanidis, Artemios, Ramos-Quiroga, Josep A, Rastam, Maria, Ryffel-Rawak, Doris, Stes, Steven, Asherson, Philip, Kooij, Sandra JJ, Bejerot, Susanne, Blackwell, Andrew, Caci, Herve, Casas-Brugué, Miquel, Carpentier, Pieter J, Edvinsson, Dan, Fayyad, John, Foeken, Karin, Fitzgerald, Michael, Gaillac, Veronique, Ginsberg, Ylva, Henry, Chantal, Krause, Johanna, Lensing, Michael B, Manor, Iris, Niederhofer, Helmut, Nunes-Filipe, Carlos, Ohlmeier, Martin D, Oswald, Pierre, Pallanti, Stefano, Pehlivanidis, Artemios, Ramos-Quiroga, Josep A, Rastam, Maria, Ryffel-Rawak, Doris, Stes, Steven, and Asherson, Philip

Abstract

BACKGROUND: Attention deficit hyperactivity disorder (ADHD) is among the most common psychiatric disorders of childhood that persists into adulthood in the majority of cases. The evidence on persistence poses several difficulties for adult psychiatry considering the lack of expertise for diagnostic assessment, limited treatment options and patient facilities across Europe. METHODS: The European Network Adult ADHD, founded in 2003, aims to increase awareness of this disorder and improve knowledge and patient care for adults with ADHD across Europe. This Consensus Statement is one of the actions taken by the European Network Adult ADHD in order to support the clinician with research evidence and clinical experience from 18 European countries in which ADHD in adults is recognised and treated. RESULTS: Besides information on the genetics and neurobiology of ADHD, three major questions are addressed in this statement: (1) What is the clinical picture of ADHD in adults? (2) How can ADHD in adults be properly diagnosed? (3) How should ADHD in adults be effectively treated? CONCLUSIONS: ADHD often presents as an impairing lifelong condition in adults, yet it is currently underdiagnosed and treated in many European countries, leading to ineffective treatment and higher costs of illness. Expertise in diagnostic assessment and treatment of ADHD in adults must increase in psychiatry. Instruments for screening and diagnosis of ADHD in adults are available and appropriate treatments exist, although more research is needed in this age group.

Published
2010
Full Text
View/download PDF

41. European consensus statement on diagnosis and treatment of adult ADHD: The European Network Adult ADHD

Author

Kooij, Sandra J J, Bejerot, Susanne, Blackwell, Andrew, Caci, Herve, Casas-Brugué, Miquel, Carpentier, Pieter Jan, Edvinsson, Dan, Fayyad, John, Foeken, Karin, Fitzgerald, Michael, Gaillac, Veronique, Ginsberg, Ylva, Henry, Chantal, Krause, Johanna, Lensing, Michael M.B., Manor, Iris, Niederhofer, Helmut, Nunes-Filipe, Carlos, Ohlmeier, Martin Detlef, Oswald, Pierre, Pallanti, Stefano, Pehlivanidis, Artemios, Ramos-Quiroga, Josep Antoni, Rastam, Maria, Ryffel-Rawak, Doris, Stes, Steven, Asherson, Philip, Kooij, Sandra J J, Bejerot, Susanne, Blackwell, Andrew, Caci, Herve, Casas-Brugué, Miquel, Carpentier, Pieter Jan, Edvinsson, Dan, Fayyad, John, Foeken, Karin, Fitzgerald, Michael, Gaillac, Veronique, Ginsberg, Ylva, Henry, Chantal, Krause, Johanna, Lensing, Michael M.B., Manor, Iris, Niederhofer, Helmut, Nunes-Filipe, Carlos, Ohlmeier, Martin Detlef, Oswald, Pierre, Pallanti, Stefano, Pehlivanidis, Artemios, Ramos-Quiroga, Josep Antoni, Rastam, Maria, Ryffel-Rawak, Doris, Stes, Steven, and Asherson, Philip

Abstract

Background: Attention deficit hyperactivity disorder (ADHD) is among the most common psychiatric disorders of childhood that persists into adulthood in the majority of cases. The evidence on persistence poses several difficulties for adult psychiatry considering the lack of expertise for diagnostic assessment, limited treatment options and patient facilities across Europe.Methods: The European Network Adult ADHD, founded in 2003, aims to increase awareness of this disorder and improve knowledge and patient care for adults with ADHD across Europe. This Consensus Statement is one of the actions taken by the European Network Adult ADHD in order to support the clinician with research evidence and clinical experience from 18 European countries in which ADHD in adults is recognised and treated.Results: Besides information on the genetics and neurobiology of ADHD, three major questions are addressed in this statement: (1) What is the clinical picture of ADHD in adults? (2) How can ADHD in adults be properly diagnosed? (3) How should ADHD in adults be effectively treated?Conclusions: ADHD often presents as an impairing lifelong condition in adults, yet it is currently underdiagnosed and treated in many European countries, leading to ineffective treatment and higher costs of illness. Expertise in diagnostic assessment and treatment of ADHD in adults must increase in psychiatry. Instruments for screening and diagnosis of ADHD in adults are available and appropriate treatments exist, although more research is needed in this age group. © 2010 Kooij et al; licensee BioMed Central Ltd., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2010

42. European consensus statement on diagnosis and treatment of adult ADHD : The European Network Adult ADHD

Author

Kooij, Sandra J. J., Bejerot, Susanne, Blackwell, Andrew, Caci, Herve, Casas-Brugué, Miquel, Carpentier, Pieter J., Edvinsson, Dan, Fayyad, John, Foeken, Karin, Fitzgerald, Michael, Gaillac, Veronique, Ginsberg, Ylva, Henry, Chantal, Krause, Johanna, Lensing, Michael B., Manor, Iris, Niederhofer, Helmut, Nunes-Filipe, Carlos, Ohlmeier, Martin D., Oswald, Pierre, Pallanti, Stefano, Pehlivanidis, Artemios, Ramos-Quiroga, Josep A., Rastam, Maria, Ryffel-Rawak, Doris, Stes, Steven, Asherson, Philip, Kooij, Sandra J. J., Bejerot, Susanne, Blackwell, Andrew, Caci, Herve, Casas-Brugué, Miquel, Carpentier, Pieter J., Edvinsson, Dan, Fayyad, John, Foeken, Karin, Fitzgerald, Michael, Gaillac, Veronique, Ginsberg, Ylva, Henry, Chantal, Krause, Johanna, Lensing, Michael B., Manor, Iris, Niederhofer, Helmut, Nunes-Filipe, Carlos, Ohlmeier, Martin D., Oswald, Pierre, Pallanti, Stefano, Pehlivanidis, Artemios, Ramos-Quiroga, Josep A., Rastam, Maria, Ryffel-Rawak, Doris, Stes, Steven, and Asherson, Philip

Abstract

Background: Attention deficit hyperactivity disorder (ADHD) is among the most common psychiatric disorders of childhood that persists into adulthood in the majority of cases. The evidence on persistence poses several difficulties for adult psychiatry considering the lack of expertise for diagnostic assessment, limited treatment options and patient facilities across Europe. Methods: The European Network Adult ADHD, founded in 2003, aims to increase awareness of this disorder and improve knowledge and patient care for adults with ADHD across Europe. This Consensus Statement is one of the actions taken by the European Network Adult ADHD in order to support the clinician with research evidence and clinical experience from 18 European countries in which ADHD in adults is recognised and treated. Results: Besides information on the genetics and neurobiology of ADHD, three major questions are addressed in this statement: (1) What is the clinical picture of ADHD in adults? (2) How can ADHD in adults be properly diagnosed? (3) How should ADHD in adults be effectively treated? Conclusions: ADHD often presents as an impairing lifelong condition in adults, yet it is currently underdiagnosed and treated in many European countries, leading to ineffective treatment and higher costs of illness. Expertise in diagnostic assessment and treatment of ADHD in adults must increase in psychiatry. Instruments for screening and diagnosis of ADHD in adults are available and appropriate treatments exist, although more research is needed in this age group.

Published
2010
Full Text
View/download PDF

43. European consensus statement on diagnosis and treatment of adult ADHD : The European Network Adult ADHD

Author

Kooij, Sandra JJ, Bejerot, Susanne, Blackwell, Andrew, Caci, Herve, Casas-Brugué, Miquel, Carpentier, Pieter J, Edvinsson, Dan, Fayyad, John, Foeken, Karin, Fitzgerald, Michael, Gaillac, Veronique, Ginsberg, Ylva, Henry, Chantal, Krause, Johanna, Lensing, Michael B, Manor, Iris, Niederhofer, Helmut, Nunes-Filipe, Carlos, Ohlmeier, Martin D, Oswald, Pierre, Pallanti, Stefano, Pehlivanidis, Artemios, Ramos-Quiroga, Josep A, Rastam, Maria, Ryffel-Rawak, Doris, Stes, Steven, Asherson, Philip, Kooij, Sandra JJ, Bejerot, Susanne, Blackwell, Andrew, Caci, Herve, Casas-Brugué, Miquel, Carpentier, Pieter J, Edvinsson, Dan, Fayyad, John, Foeken, Karin, Fitzgerald, Michael, Gaillac, Veronique, Ginsberg, Ylva, Henry, Chantal, Krause, Johanna, Lensing, Michael B, Manor, Iris, Niederhofer, Helmut, Nunes-Filipe, Carlos, Ohlmeier, Martin D, Oswald, Pierre, Pallanti, Stefano, Pehlivanidis, Artemios, Ramos-Quiroga, Josep A, Rastam, Maria, Ryffel-Rawak, Doris, Stes, Steven, and Asherson, Philip

Abstract

BACKGROUND: Attention deficit hyperactivity disorder (ADHD) is among the most common psychiatric disorders of childhood that persists into adulthood in the majority of cases. The evidence on persistence poses several difficulties for adult psychiatry considering the lack of expertise for diagnostic assessment, limited treatment options and patient facilities across Europe. METHODS: The European Network Adult ADHD, founded in 2003, aims to increase awareness of this disorder and improve knowledge and patient care for adults with ADHD across Europe. This Consensus Statement is one of the actions taken by the European Network Adult ADHD in order to support the clinician with research evidence and clinical experience from 18 European countries in which ADHD in adults is recognised and treated. RESULTS: Besides information on the genetics and neurobiology of ADHD, three major questions are addressed in this statement: (1) What is the clinical picture of ADHD in adults? (2) How can ADHD in adults be properly diagnosed? (3) How should ADHD in adults be effectively treated? CONCLUSIONS: ADHD often presents as an impairing lifelong condition in adults, yet it is currently underdiagnosed and treated in many European countries, leading to ineffective treatment and higher costs of illness. Expertise in diagnostic assessment and treatment of ADHD in adults must increase in psychiatry. Instruments for screening and diagnosis of ADHD in adults are available and appropriate treatments exist, although more research is needed in this age group.

Published
2010
Full Text
View/download PDF

44. European consensus statement on diagnosis and treatment of adult ADHD : The European Network Adult ADHD

Author

Kooij, Sandra JJ, Bejerot, Susanne, Blackwell, Andrew, Caci, Herve, Casas-Brugué, Miquel, Carpentier, Pieter J, Edvinsson, Dan, Fayyad, John, Foeken, Karin, Fitzgerald, Michael, Gaillac, Veronique, Ginsberg, Ylva, Henry, Chantal, Krause, Johanna, Lensing, Michael B, Manor, Iris, Niederhofer, Helmut, Nunes-Filipe, Carlos, Ohlmeier, Martin D, Oswald, Pierre, Pallanti, Stefano, Pehlivanidis, Artemios, Ramos-Quiroga, Josep A, Rastam, Maria, Ryffel-Rawak, Doris, Stes, Steven, Asherson, Philip, Kooij, Sandra JJ, Bejerot, Susanne, Blackwell, Andrew, Caci, Herve, Casas-Brugué, Miquel, Carpentier, Pieter J, Edvinsson, Dan, Fayyad, John, Foeken, Karin, Fitzgerald, Michael, Gaillac, Veronique, Ginsberg, Ylva, Henry, Chantal, Krause, Johanna, Lensing, Michael B, Manor, Iris, Niederhofer, Helmut, Nunes-Filipe, Carlos, Ohlmeier, Martin D, Oswald, Pierre, Pallanti, Stefano, Pehlivanidis, Artemios, Ramos-Quiroga, Josep A, Rastam, Maria, Ryffel-Rawak, Doris, Stes, Steven, and Asherson, Philip

Abstract

BACKGROUND: Attention deficit hyperactivity disorder (ADHD) is among the most common psychiatric disorders of childhood that persists into adulthood in the majority of cases. The evidence on persistence poses several difficulties for adult psychiatry considering the lack of expertise for diagnostic assessment, limited treatment options and patient facilities across Europe. METHODS: The European Network Adult ADHD, founded in 2003, aims to increase awareness of this disorder and improve knowledge and patient care for adults with ADHD across Europe. This Consensus Statement is one of the actions taken by the European Network Adult ADHD in order to support the clinician with research evidence and clinical experience from 18 European countries in which ADHD in adults is recognised and treated. RESULTS: Besides information on the genetics and neurobiology of ADHD, three major questions are addressed in this statement: (1) What is the clinical picture of ADHD in adults? (2) How can ADHD in adults be properly diagnosed? (3) How should ADHD in adults be effectively treated? CONCLUSIONS: ADHD often presents as an impairing lifelong condition in adults, yet it is currently underdiagnosed and treated in many European countries, leading to ineffective treatment and higher costs of illness. Expertise in diagnostic assessment and treatment of ADHD in adults must increase in psychiatry. Instruments for screening and diagnosis of ADHD in adults are available and appropriate treatments exist, although more research is needed in this age group.

Published
2010
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45. European consensus statement on diagnosis and treatment of adult ADHD: The European Network Adult ADHD

Author

Kooij, Sandra J. J., Bejerot, Susanne, Blackwell, Andrew, Caci, Herve, Casas-Brugue, Miquel, Carpentier, Pieter J., Edvinsson, Dan, Fayyad, John, Foeken, Karin, Fitzgerald, Michael, Gaillac, Veronique, Ginsberg, Ylva, Henry, Chantal, Krause, Johanna, Lensing, Michael B., Manor, Iris, Niederhofer, Helmut, Nunes-Filipe, Carlos, Ohlmeier, Martin D., Oswald, Pierre, Pallanti, Stefano, Pehlivanidis, Artemios, Ramos-Quiroga, Josep A., Råstam, Maria, Ryffel-Rawak, Doris, Stes, Steven, Asherson, Philip, Kooij, Sandra J. J., Bejerot, Susanne, Blackwell, Andrew, Caci, Herve, Casas-Brugue, Miquel, Carpentier, Pieter J., Edvinsson, Dan, Fayyad, John, Foeken, Karin, Fitzgerald, Michael, Gaillac, Veronique, Ginsberg, Ylva, Henry, Chantal, Krause, Johanna, Lensing, Michael B., Manor, Iris, Niederhofer, Helmut, Nunes-Filipe, Carlos, Ohlmeier, Martin D., Oswald, Pierre, Pallanti, Stefano, Pehlivanidis, Artemios, Ramos-Quiroga, Josep A., Råstam, Maria, Ryffel-Rawak, Doris, Stes, Steven, and Asherson, Philip

Abstract

Background: Attention deficit hyperactivity disorder (ADHD) is among the most common psychiatric disorders of childhood that persists into adulthood in the majority of cases. The evidence on persistence poses several difficulties for adult psychiatry considering the lack of expertise for diagnostic assessment, limited treatment options and patient facilities across Europe. Methods: The European Network Adult ADHD, founded in 2003, aims to increase awareness of this disorder and improve knowledge and patient care for adults with ADHD across Europe. This Consensus Statement is one of the actions taken by the European Network Adult ADHD in order to support the clinician with research evidence and clinical experience from 18 European countries in which ADHD in adults is recognised and treated. Results: Besides information on the genetics and neurobiology of ADHD, three major questions are addressed in this statement: (1) What is the clinical picture of ADHD in adults? (2) How can ADHD in adults be properly diagnosed? (3) How should ADHD in adults be effectively treated? Conclusions: ADHD often presents as an impairing lifelong condition in adults, yet it is currently underdiagnosed and treated in many European countries, leading to ineffective treatment and higher costs of illness. Expertise in diagnostic assessment and treatment of ADHD in adults must increase in psychiatry. Instruments for screening and diagnosis of ADHD in adults are available and appropriate treatments exist, although more research is needed in this age group.

Published
2010

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