Search

Your search keyword '"Ouellet, M"' showing total 10 results
Start Over Author "Ouellet, M" Database OAIster
10 results on '"Ouellet, M"'

2. The vector-apodizing phase plate coronagraph: design, current performance, and future development

Author

Doelman, D. S., Snik, F., Por, E. H., Bos, S. P., Otten, G. P. P. L., Kenworthy, M., Haffert, S. Y., Wilby, M., Bohn, A. J., Sutlieff, B. J., Miller, K., Ouellet, M., de Boer, J., Keller, C. U., Escuti, M. J., Shi, S., Warriner, N. Z., Hornburg, K. J., Birkby, J. L., Males, J., Morzinski, K. M., Close, L. M., Codona, J., Long, J., Schatz, L., Lumbres, J., Rodack, A., Van Gorkom, K., Hedglen, A, Guyon, O., Lozi, J., Groff, T., Chilcote, J., Jovanovic, N., Thibault, S., de Jonge, C., Allain, G., Vallée, C., Patel, D., Côté, O., Marois, C., Hinz, P., Stone, J., Skemer, A., Briesemeister, Z., Boehle, A., Glauser, A. M., Taylor, W., Baudoz, P., Huby, E., Absil, O., Carlomagno, B., Delacroix, C., Doelman, D. S., Snik, F., Por, E. H., Bos, S. P., Otten, G. P. P. L., Kenworthy, M., Haffert, S. Y., Wilby, M., Bohn, A. J., Sutlieff, B. J., Miller, K., Ouellet, M., de Boer, J., Keller, C. U., Escuti, M. J., Shi, S., Warriner, N. Z., Hornburg, K. J., Birkby, J. L., Males, J., Morzinski, K. M., Close, L. M., Codona, J., Long, J., Schatz, L., Lumbres, J., Rodack, A., Van Gorkom, K., Hedglen, A, Guyon, O., Lozi, J., Groff, T., Chilcote, J., Jovanovic, N., Thibault, S., de Jonge, C., Allain, G., Vallée, C., Patel, D., Côté, O., Marois, C., Hinz, P., Stone, J., Skemer, A., Briesemeister, Z., Boehle, A., Glauser, A. M., Taylor, W., Baudoz, P., Huby, E., Absil, O., Carlomagno, B., and Delacroix, C.

Abstract

Over the last decade, the vector-apodizing phase plate (vAPP) coronagraph has been developed from concept to on-sky application in many high-contrast imaging systems on 8-m class telescopes. The vAPP is an geometric-phase patterned coronagraph that is inherently broadband, and its manufacturing is enabled only by direct-write technology for liquid-crystal patterns. The vAPP generates two coronagraphic PSFs that cancel starlight on opposite sides of the point spread function (PSF) and have opposite circular polarization states. The efficiency, that is the amount of light in these PSFs, depends on the retardance offset from half-wave of the liquid-crystal retarder. Using different liquid-crystal recipes to tune the retardance, different vAPPs operate with high efficiencies ($>96\%$) in the visible and thermal infrared (0.55 $\mu$m to 5 $\mu$m). Since 2015, seven vAPPs have been installed in a total of six different instruments, including Magellan/MagAO, Magellan/MagAO-X, Subaru/SCExAO, and LBT/LMIRcam. Using two integral field spectrographs installed on the latter two instruments, these vAPPs can provide low-resolution spectra (R$\sim$30) between 1 $\mu$m and 5 $\mu$m. We review the design process, development, commissioning, on-sky performance, and first scientific results of all commissioned vAPPs. We report on the lessons learned and conclude with perspectives for future developments and applications., Comment: 38 pages, 17 figures, accepted for publication in Applied Optics, added NSF grant acknowledgement

Published
2021
Full Text
View/download PDF

3. Response to correspondence on 'Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation'.

Author

Gurumurthy, CB, O'Brien, AR, Quadros, RM, Adams, J, Alcaide, P, Ayabe, S, Ballard, J, Batra, SK, Beauchamp, M-C, Becker, KA, Bernas, G, Brough, D, Carrillo-Salinas, F, Chan, W, Chen, H, Dawson, R, DeMambro, V, D'Hont, J, Dibb, K, Eudy, JD, Gan, L, Gao, J, Gonzales, A, Guntur, A, Guo, H, Harms, DW, Harrington, A, Hentges, KE, Humphreys, N, Imai, S, Ishii, H, Iwama, M, Jonasch, E, Karolak, M, Keavney, B, Khin, N-C, Konno, M, Kotani, Y, Kunihiro, Y, Lakshmanan, I, Larochelle, C, Lawrence, CB, Li, L, Lindner, V, Liu, X-D, Lopez-Castejon, G, Loudon, A, Lowe, J, Jerome-Majeweska, L, Matsusaka, T, Miura, H, Miyasaka, Y, Morpurgo, B, Motyl, K, Nabeshima, Y-I, Nakade, K, Nakashiba, T, Nakashima, K, Obata, Y, Ogiwara, S, Ouellet, M, Oxburgh, L, Piltz, S, Pinz, I, Ponnusamy, MP, Ray, D, Redder, RJ, Rosen, CJ, Ross, N, Ruhe, MT, Ryzhova, L, Salvador, AM, Alam, SS, Sedlacek, R, Sharma, K, Smith, C, Staes, K, Starrs, L, Sugiyama, F, Takahashi, S, Tanaka, T, Trafford, A, Uno, Y, Vanhoutte, L, Vanrockeghem, F, Willis, BJ, Wright, CS, Yamauchi, Y, Yi, X, Yoshimi, K, Zhang, X, Zhang, Y, Ohtsuka, M, Das, S, Garry, DJ, Hochepied, T, Thomas, P, Parker-Thornburg, J, Adamson, AD, Yoshiki, A, Schmouth, J-F, Golovko, A, Thompson, WR, Lloyd, KCK, Wood, JA, Cowan, M, Mashimo, T, Mizuno, S, Zhu, H, Kasparek, P, Liaw, L, Miano, JM, Burgio, G, Gurumurthy, CB, O'Brien, AR, Quadros, RM, Adams, J, Alcaide, P, Ayabe, S, Ballard, J, Batra, SK, Beauchamp, M-C, Becker, KA, Bernas, G, Brough, D, Carrillo-Salinas, F, Chan, W, Chen, H, Dawson, R, DeMambro, V, D'Hont, J, Dibb, K, Eudy, JD, Gan, L, Gao, J, Gonzales, A, Guntur, A, Guo, H, Harms, DW, Harrington, A, Hentges, KE, Humphreys, N, Imai, S, Ishii, H, Iwama, M, Jonasch, E, Karolak, M, Keavney, B, Khin, N-C, Konno, M, Kotani, Y, Kunihiro, Y, Lakshmanan, I, Larochelle, C, Lawrence, CB, Li, L, Lindner, V, Liu, X-D, Lopez-Castejon, G, Loudon, A, Lowe, J, Jerome-Majeweska, L, Matsusaka, T, Miura, H, Miyasaka, Y, Morpurgo, B, Motyl, K, Nabeshima, Y-I, Nakade, K, Nakashiba, T, Nakashima, K, Obata, Y, Ogiwara, S, Ouellet, M, Oxburgh, L, Piltz, S, Pinz, I, Ponnusamy, MP, Ray, D, Redder, RJ, Rosen, CJ, Ross, N, Ruhe, MT, Ryzhova, L, Salvador, AM, Alam, SS, Sedlacek, R, Sharma, K, Smith, C, Staes, K, Starrs, L, Sugiyama, F, Takahashi, S, Tanaka, T, Trafford, A, Uno, Y, Vanhoutte, L, Vanrockeghem, F, Willis, BJ, Wright, CS, Yamauchi, Y, Yi, X, Yoshimi, K, Zhang, X, Zhang, Y, Ohtsuka, M, Das, S, Garry, DJ, Hochepied, T, Thomas, P, Parker-Thornburg, J, Adamson, AD, Yoshiki, A, Schmouth, J-F, Golovko, A, Thompson, WR, Lloyd, KCK, Wood, JA, Cowan, M, Mashimo, T, Mizuno, S, Zhu, H, Kasparek, P, Liaw, L, Miano, JM, and Burgio, G

Published
2021

4. The vector-apodizing phase plate coronagraph: design, current performance, and future development

Author

Doelman, D. S., Snik, F., Por, E. H., Bos, S. P., Otten, G. P. P. L., Kenworthy, M., Haffert, S. Y., Wilby, M., Bohn, A. J., Sutlieff, B. J., Miller, K., Ouellet, M., de Boer, J., Keller, C. U., Escuti, M. J., Shi, S., Warriner, N. Z., Hornburg, K. J., Birkby, J. L., Males, J., Morzinski, K. M., Close, L. M., Codona, J., Long, J., Schatz, L., Lumbres, J., Rodack, A., Van Gorkom, K., Hedglen, A, Guyon, O., Lozi, J., Groff, T., Chilcote, J., Jovanovic, N., Thibault, S., de Jonge, C., Allain, G., Vallée, C., Patel, D., Côté, O., Marois, C., Hinz, P., Stone, J., Skemer, A., Briesemeister, Z., Boehle, A., Glauser, A. M., Taylor, W., Baudoz, P., Huby, E., Absil, O., Carlomagno, B., Delacroix, C., Doelman, D. S., Snik, F., Por, E. H., Bos, S. P., Otten, G. P. P. L., Kenworthy, M., Haffert, S. Y., Wilby, M., Bohn, A. J., Sutlieff, B. J., Miller, K., Ouellet, M., de Boer, J., Keller, C. U., Escuti, M. J., Shi, S., Warriner, N. Z., Hornburg, K. J., Birkby, J. L., Males, J., Morzinski, K. M., Close, L. M., Codona, J., Long, J., Schatz, L., Lumbres, J., Rodack, A., Van Gorkom, K., Hedglen, A, Guyon, O., Lozi, J., Groff, T., Chilcote, J., Jovanovic, N., Thibault, S., de Jonge, C., Allain, G., Vallée, C., Patel, D., Côté, O., Marois, C., Hinz, P., Stone, J., Skemer, A., Briesemeister, Z., Boehle, A., Glauser, A. M., Taylor, W., Baudoz, P., Huby, E., Absil, O., Carlomagno, B., and Delacroix, C.

Abstract

Over the last decade, the vector-apodizing phase plate (vAPP) coronagraph has been developed from concept to on-sky application in many high-contrast imaging systems on 8-m class telescopes. The vAPP is an geometric-phase patterned coronagraph that is inherently broadband, and its manufacturing is enabled only by direct-write technology for liquid-crystal patterns. The vAPP generates two coronagraphic PSFs that cancel starlight on opposite sides of the point spread function (PSF) and have opposite circular polarization states. The efficiency, that is the amount of light in these PSFs, depends on the retardance offset from half-wave of the liquid-crystal retarder. Using different liquid-crystal recipes to tune the retardance, different vAPPs operate with high efficiencies ($>96\%$) in the visible and thermal infrared (0.55 $\mu$m to 5 $\mu$m). Since 2015, seven vAPPs have been installed in a total of six different instruments, including Magellan/MagAO, Magellan/MagAO-X, Subaru/SCExAO, and LBT/LMIRcam. Using two integral field spectrographs installed on the latter two instruments, these vAPPs can provide low-resolution spectra (R$\sim$30) between 1 $\mu$m and 5 $\mu$m. We review the design process, development, commissioning, on-sky performance, and first scientific results of all commissioned vAPPs. We report on the lessons learned and conclude with perspectives for future developments and applications., Comment: 38 pages, 17 figures, accepted for publication in Applied Optics, added NSF grant acknowledgement

Published
2021
Full Text
View/download PDF

5. Impact of the COVID-19 pandemic on older adults: rapid review

Author

Lebrasseur, A., Fortin-Bédard, N., Lettre, J., Raymond, E., Bussières, E.-L., Lapierre, N., Faieta, J., Vincent, C., Duchesne, L., Ouellet, M.-C., Gagnon, E., Tourigny, A., Lamontagne, M.-È., Routhier, F., Lebrasseur, A., Fortin-Bédard, N., Lettre, J., Raymond, E., Bussières, E.-L., Lapierre, N., Faieta, J., Vincent, C., Duchesne, L., Ouellet, M.-C., Gagnon, E., Tourigny, A., Lamontagne, M.-È., and Routhier, F.

Abstract

Background: The COVID-19 pandemic has drastically changed the lives of countless members of the general population. Older adults are known to experience loneliness, age discrimination, and excessive worry. It is therefore reasonable to anticipate that they would experience greater negative outcomes related to the COVID-19 pandemic given their increased isolation and risk for complications than younger adults. Objective: This study aims to synthesize the existing research on the impact of the COVID-19 pandemic, and associated isolation and protective measures, on older adults. The secondary objective is to investigate the impact of the COVID-19 pandemic, and associated isolation and protective measures, on older adults with Alzheimer disease and related dementias. Methods: A rapid review of the published literature was conducted on October 6, 2020, through a search of 6 online databases to synthesize results from published original studies regarding the impact of the COVID-19 pandemic on older adults. The Human Development Model conceptual framework–Disability Creation Process was used to describe and understand interactions between personal factors, environmental factors, and life habits. Methods and results are reported following the Preferred Reporting Items for Systematic Reviews and Meta-analyses Statement. Results: A total of 135 records were included from the initial search strategy of 13,452 individual studies. Of these, 113 (83.7%) studies were determined to be of level 4 according to the levels of evidence classification by the Centre for Evidence-Based Medicine. The presence of psychological symptoms, exacerbation of ageism, and physical deterioration of aged populations were reported in the included studies. Decreased social life and fewer in-person social interactions reported during the COVID-19 pandemic were occasionally associated with reduced quality of life and increased depression. Difficulties accessing services, sleep disturbances, and a reductio

Published
2021

6. Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation.

Author

Gurumurthy, CB, O'Brien, AR, Quadros, RM, Adams, J, Alcaide, P, Ayabe, S, Ballard, J, Batra, SK, Beauchamp, M-C, Becker, KA, Bernas, G, Brough, D, Carrillo-Salinas, F, Chan, W, Chen, H, Dawson, R, DeMambro, V, D'Hont, J, Dibb, KM, Eudy, JD, Gan, L, Gao, J, Gonzales, A, Guntur, AR, Guo, H, Harms, DW, Harrington, A, Hentges, KE, Humphreys, N, Imai, S, Ishii, H, Iwama, M, Jonasch, E, Karolak, M, Keavney, B, Khin, N-C, Konno, M, Kotani, Y, Kunihiro, Y, Lakshmanan, I, Larochelle, C, Lawrence, CB, Li, L, Lindner, V, Liu, X-D, Lopez-Castejon, G, Loudon, A, Lowe, J, Jerome-Majewska, LA, Matsusaka, T, Miura, H, Miyasaka, Y, Morpurgo, B, Motyl, K, Nabeshima, Y-I, Nakade, K, Nakashiba, T, Nakashima, K, Obata, Y, Ogiwara, S, Ouellet, M, Oxburgh, L, Piltz, S, Pinz, I, Ponnusamy, MP, Ray, D, Redder, RJ, Rosen, CJ, Ross, N, Ruhe, MT, Ryzhova, L, Salvador, AM, Alam, SS, Sedlacek, R, Sharma, K, Smith, C, Staes, K, Starrs, L, Sugiyama, F, Takahashi, S, Tanaka, T, Trafford, AW, Uno, Y, Vanhoutte, L, Vanrockeghem, F, Willis, BJ, Wright, CS, Yamauchi, Y, Yi, X, Yoshimi, K, Zhang, X, Zhang, Y, Ohtsuka, M, Das, S, Garry, DJ, Hochepied, T, Thomas, P, Parker-Thornburg, J, Adamson, AD, Yoshiki, A, Schmouth, J-F, Golovko, A, Thompson, WR, Lloyd, KCK, Wood, JA, Cowan, M, Mashimo, T, Mizuno, S, Zhu, H, Kasparek, P, Liaw, L, Miano, JM, Burgio, G, Gurumurthy, CB, O'Brien, AR, Quadros, RM, Adams, J, Alcaide, P, Ayabe, S, Ballard, J, Batra, SK, Beauchamp, M-C, Becker, KA, Bernas, G, Brough, D, Carrillo-Salinas, F, Chan, W, Chen, H, Dawson, R, DeMambro, V, D'Hont, J, Dibb, KM, Eudy, JD, Gan, L, Gao, J, Gonzales, A, Guntur, AR, Guo, H, Harms, DW, Harrington, A, Hentges, KE, Humphreys, N, Imai, S, Ishii, H, Iwama, M, Jonasch, E, Karolak, M, Keavney, B, Khin, N-C, Konno, M, Kotani, Y, Kunihiro, Y, Lakshmanan, I, Larochelle, C, Lawrence, CB, Li, L, Lindner, V, Liu, X-D, Lopez-Castejon, G, Loudon, A, Lowe, J, Jerome-Majewska, LA, Matsusaka, T, Miura, H, Miyasaka, Y, Morpurgo, B, Motyl, K, Nabeshima, Y-I, Nakade, K, Nakashiba, T, Nakashima, K, Obata, Y, Ogiwara, S, Ouellet, M, Oxburgh, L, Piltz, S, Pinz, I, Ponnusamy, MP, Ray, D, Redder, RJ, Rosen, CJ, Ross, N, Ruhe, MT, Ryzhova, L, Salvador, AM, Alam, SS, Sedlacek, R, Sharma, K, Smith, C, Staes, K, Starrs, L, Sugiyama, F, Takahashi, S, Tanaka, T, Trafford, AW, Uno, Y, Vanhoutte, L, Vanrockeghem, F, Willis, BJ, Wright, CS, Yamauchi, Y, Yi, X, Yoshimi, K, Zhang, X, Zhang, Y, Ohtsuka, M, Das, S, Garry, DJ, Hochepied, T, Thomas, P, Parker-Thornburg, J, Adamson, AD, Yoshiki, A, Schmouth, J-F, Golovko, A, Thompson, WR, Lloyd, KCK, Wood, JA, Cowan, M, Mashimo, T, Mizuno, S, Zhu, H, Kasparek, P, Liaw, L, Miano, JM, and Burgio, G

Abstract

BACKGROUND: CRISPR-Cas9 gene-editing technology has facilitated the generation of knockout mice, providing an alternative to cumbersome and time-consuming traditional embryonic stem cell-based methods. An earlier study reported up to 16% efficiency in generating conditional knockout (cKO or floxed) alleles by microinjection of 2 single guide RNAs (sgRNA) and 2 single-stranded oligonucleotides as donors (referred herein as "two-donor floxing" method). RESULTS: We re-evaluate the two-donor method from a consortium of 20 laboratories across the world. The dataset constitutes 56 genetic loci, 17,887 zygotes, and 1718 live-born mice, of which only 15 (0.87%) mice contain cKO alleles. We subject the dataset to statistical analyses and a machine learning algorithm, which reveals that none of the factors analyzed was predictive for the success of this method. We test some of the newer methods that use one-donor DNA on 18 loci for which the two-donor approach failed to produce cKO alleles. We find that the one-donor methods are 10- to 20-fold more efficient than the two-donor approach. CONCLUSION: We propose that the two-donor method lacks efficiency because it relies on two simultaneous recombination events in cis, an outcome that is dwarfed by pervasive accompanying undesired editing events. The methods that use one-donor DNA are fairly efficient as they rely on only one recombination event, and the probability of correct insertion of the donor cassette without unanticipated mutational events is much higher. Therefore, one-donor methods offer higher efficiencies for the routine generation of cKO animal models.

Published
2019

10. Identification of nitrogen responsive genes in poplar roots grown under two contrasting nitrogen levels

Author

Pitre, F, Cooke, J, Caron, S, Kayal, W, Ouellet, M, Lam, K, GUIDI NISSIM, W, Mackay, J, Frederic E. Pitre, Janice E. K. Cooke, Sebastien Caron, Walid E. Kayal, Mario Ouellet, Kimberley S. W. Lam, Werther Guidi Nissim, John J. MacKay, Pitre, F, Cooke, J, Caron, S, Kayal, W, Ouellet, M, Lam, K, GUIDI NISSIM, W, Mackay, J, Frederic E. Pitre, Janice E. K. Cooke, Sebastien Caron, Walid E. Kayal, Mario Ouellet, Kimberley S. W. Lam, Werther Guidi Nissim, and John J. MacKay

Abstract

We investigated the short-term response of poplar roots to low and high nitrogen availability in order to elucidate the mechanisms involved in nutrient acquisition. After 28 days of fertilization with low versus high ammonium nitrate, an increase in aboveground biomass was observed accompanied by a decrease in root biomass, reducing the root: shoot ratio after 28 days. These changes in biomass allocation were accompanied by changes in root architecture and altered gene expression. The gene expression response was evaluated after 7 days using a custom cDNA micrarray following transfer to low and high nitrogen supply. We found that 56 sequences were differentially expressed in poplar roots. Many of these 56 genes could be associated with putative roles in development or response to biotic and abiotic stress. A time course analysis of selected cell wall-related genes by RT-qPCR confirmed the expression patterns obtained by microarray and also showed the timing of this differential response. Our results show that patterns of transcript accumulation in roots of poplars are influenced by nitrogen supply, providing evidence of unique nitrogen-adaptative mechanisms.

Published
2014

Catalog

Books, media, physical & digital resources
See catalog results