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Human non-small cell lung cancers (NSCLCs) with activating mutations in EGFR frequently respond to treatment with EGFR-targeted tyrosine kinase inhibitors (TKIs), such as erlotinib, but responses are not durable, as tumors acquire resistance. Secondary mut

Human non-small cell lung cancers (NSCLCs) with activating mutations in EGFR frequently respond to treatment with EGFR-targeted tyrosine kinase inhibitors (TKIs), such as erlotinib, but responses are not durable, as tumors acquire resistance. Secondary mut

Drop weight tests (DWT) and rubber wheel abrasion tests (RWAT) were carried out on an ore containing haematite and quartz and a synthetic ore containing grout, epoxy and glass beads. The data were fitted to the parameters of the t(10)) model, where t(10) represents particles finer than one tenth of their particle size and is related to specific communication energy using an equation which includes the curve fitting parameters A and b. The product of A and b can be used to provide a single measure of the resistance to breakage by impact for a reasonable broad range of particle sizes. The t(10) model curves were also obtained from dry SWAT tests by finding the A and b values which minimise the least square of the objective function using Excel solver routines. Comparison of the A and b values for the two types of test showed considerable differences due to the large rocks and pebbles used in DWT and the small granular ores in SWAT. A modified t(10) model taking into account particle size was applied to the dry SWAT results and showed improved predictability. SWAT results obtained under wet conditions were fitted to the modified t(10) model and the model fitted the data more suitably than under dry conditions. The specific rate of breakage values were higher than for dry grinding. The SWAT results showed that the t(10) model can be fitted to data obtained from experimental tests using the modified t(10) model. SWAT requires significantly less test material than DWT., Drop weight tests (DWT) and rubber wheel abrasion tests (RWAT) were carried out on an ore containing haematite and quartz and a synthetic ore containing grout, epoxy and glass beads. The data were fitted to the parameters of the t(10)) model, where t(10) represents particles finer than one tenth of their particle size and is related to specific communication energy using an equation which includes the curve fitting parameters A and b. The product of A and b can be used to provide a single measure of the resistance to breakage by impact for a reasonable broad range of particle sizes. The t(10) model curves were also obtained from dry SWAT tests by finding the A and b values which minimise the least square of the objective function using Excel solver routines. Comparison of the A and b values for the two types of test showed considerable differences due to the large rocks and pebbles used in DWT and the small granular ores in SWAT. A modified t(10) model taking into account particle size was applied to the dry SWAT results and showed improved predictability. SWAT results obtained under wet conditions were fitted to the modified t(10) model and the model fitted the data more suitably than under dry conditions. The specific rate of breakage values were higher than for dry grinding. The SWAT results showed that the t(10) model can be fitted to data obtained from experimental tests using the modified t(10) model. SWAT requires significantly less test material than DWT.

The abrasion wheel test used to determine the contribution of abrasive wear and friction to the total wear of steel grinding media provides an opportunity to study ore breakage as well. Tests were carried out using standard Ottawa foundry sand. It is shown that the abrasive wheel test produces fine particles, that it can be used to determine the operating work index, the locked cycle work index and the t10 function for a given ore, that the amount of prepared ore to determine the breakage parameters varies with the test method used, that in conjunction with these tests steel media abrasive wear and friction can be determined, and that all test results indicate a relationship between steel wear, friction, and abrasive ore breakage. Implications of the work and further directions it may take are considered., The abrasion wheel test used to determine the contribution of abrasive wear and friction to the total wear of steel grinding media provides an opportunity to study ore breakage as well. Tests were carried out using standard Ottawa foundry sand. It is shown that the abrasive wheel test produces fine particles, that it can be used to determine the operating work index, the locked cycle work index and the t10 function for a given ore, that the amount of prepared ore to determine the breakage parameters varies with the test method used, that in conjunction with these tests steel media abrasive wear and friction can be determined, and that all test results indicate a relationship between steel wear, friction, and abrasive ore breakage. Implications of the work and further directions it may take are considered.