Literature review written by University of Scranton undergraduate students Christina Gavalas and Marjorie Toron, as part of their coursework for Occupational Therapy 494: Evidence-Based Research. Gavalas and Toron were selected by a panel of faculty and staff as the winners of the University's 2016 undergraduate Library Research Prize., Proprioceptive interventions apply deep pressure to the body through weighted instruments or devices that deliver pressure, such as weighted vests, weighted blankets, and the Hug Machine. This project aims to present occupational therapists with an analysis of current proprioceptive interventions for children with autism and attention-deficit/hyperactivity disorder (ADHD) as well as an evidence-based protocol for the implementation of specific proprioceptive intervention tools. Following the development of a PICO question, a search strategy was initiated using databases including OT Search, CINAHL, ProQuest Central, SpringerLink, Google Scholar, ERIC, OT Seeker, PubMed, and Science Direct. After a search of the literature, 45 articles from 22 journals were reviewed, and 12 articles met the inclusion criteria for this project. All 12 studies included in the matrix are Level III evidence or higher, published after the year 2000 (except articles on the Hug Machine), and conducted on children under the age of 18 with autism or ADHD focusing on outcomes of decreased stereotypical behaviors, increased attention, or decreased arousal. All 12 articles were analyzed to detect trends in the data, and four articles were carefully selected for critical appraisal. Data were synthesized following this analysis, and clinical implications and areas for future research were discussed. Findings indicate that weighted vests are the most practical to use in conjunction with academic activities, and a preliminary evidence-based protocol for weighted vest interventions was derived. Due to the little available evidence on the efficacy of weighted blankets and the Hug Machine, more research should be conducted on these intervention tools before a determination can be made about their usefulness in practice.