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Item does not contain fulltext, Diagnostic work-up and risk stratification in patients with bladder cancer before and after treatment must be refined to optimize management and improve outcomes. MRI has been suggested as a non-invasive technique for bladder cancer staging and assessment of response to systemic therapy. The Vesical Imaging-Reporting And Data System (VI-RADS) was developed to standardize bladder MRI image acquisition, interpretation and reporting and enables accurate prediction of muscle-wall invasion of bladder cancer. MRI is available in many centres but is not yet recommended as a first-line test for bladder cancer owing to a lack of high-quality evidence. Consensus-based evidence on the use of MRI-VI-RADS for bladder cancer care is needed to serve as a benchmark for formulating guidelines and research agendas until further evidence from randomized trials becomes available., 01 april 2024

BACKGROUND: The concordance rates of transperineal (TP) versus transrectal (TR) prostate biopsies with radical prostatectomy (RP) specimen have been assessed poorly in men diagnosed with magnetic resonance imaging (MRI)-targeted biopsy (TBx). OBJECTIVE: To evaluate International Society of Urological Pathology (ISUP) concordance rates between the final pathology at RP and MRI-TBx or MRI-TBx + random biopsy (RB) according to the biopsy approach. DESIGN, SETTING, AND PARTICIPANTS: A multi-institutional database included patients diagnosed with TP or TR treated with RP. INTERVENTION: TP-TBx or TR-TBx of the prostate. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: The ISUP grade at biopsy was compared with the final pathology. A multivariable logistic regression analysis (MVA) was performed to assess the association between the biopsy approach (TP-TBx vs TR-TBx) and ISUP upgrading, downgrading, concordance, and clinically relevant increase (CRI). RESULTS AND LIMITATIONS: Overall, 752 (59%) versus 530 (41%) patients underwent TR versus TP. At the MVA, TP-TBx was an independent predictor of upgrading (odds ratio [OR] 0.6, 95% confidence interval [CI] 0.4-0.9, p < 0.01) and improved concordance relative to the final pathology (OR 1.7, 95% CI 1.2-2.5, p < 0.01) after adjusting for age, cT stage, Prostate Imaging Reporting and Data System, number of targeted cores, prostate-specific antigen, and prostate volume. Moreover, TP-TBx was associated with a lower risk of CRI than TR-TBx (OR 0.7, p < 0.01). This held true when considering patients who underwent MRI-TBx + RB (OR 0.6, p < 0.01). The inclusion of men who had RP represents a potential selection bias. CONCLUSIONS: The adoption of TP-TBx compared with TR-TBx may reduce the risk of upgrading and improve the concordance of biopsy grade with the final pathology. The TP approach decreases the odds of CRI with improved patient selection for the correct active treatment. PATIENT SUMMARY: In this report, we evaluated whether tra

Ultraluminous X-ray sources (ULXs) are extragalactic X-ray emitters located off-centre of their host galaxy and with a luminosity in excess of a few 1039 erg s−1, if emitted isotropically1,2. The discovery of periodic modulation revealed that in some ULXs the accreting compact object is a neutron star3–7, indicating luminosities substantially above their Eddington limit. The most extreme object in this respect is NGC 5907 ULX-1 (ULX1), with a peak luminosity that is 500 times its Eddington limit. During a Chandra observation to probe a low state of ULX1, we detected diffuse X-ray emission at the position of ULX1. Its diameter is 2.7 ± 1.0 arcsec and contains 25 photons, none below 0.8 keV. We interpret this extended structure as an expanding nebula powered by the wind of ULX1. Its diameter of about 200 pc, characteristic energy of ~1.9 keV and luminosity of ~2 × 1038 erg s−1 imply a mechanical power of 1.3 × 1041 erg s−1 and an age of ~7 × 104 yr. This interpretation suggests that a genuinely super-Eddington regime can be sustained for timescales much longer than the spin-up time of the neutron star powering the system. As the mechanical power from a single ULX nebula can rival the injection rate of cosmic rays of an entire galaxy8, ULX nebulae could be important cosmic ray accelerators9.

Ultraluminous X-ray sources (ULXs) are extragalactic X-ray emitters located off-centre of their host galaxy and with a luminosity in excess of a few 1039 erg s−1, if emitted isotropically1,2. The discovery of periodic modulation revealed that in some ULXs the accreting compact object is a neutron star3–7, indicating luminosities substantially above their Eddington limit. The most extreme object in this respect is NGC 5907 ULX-1 (ULX1), with a peak luminosity that is 500 times its Eddington limit. During a Chandra observation to probe a low state of ULX1, we detected diffuse X-ray emission at the position of ULX1. Its diameter is 2.7 ± 1.0 arcsec and contains 25 photons, none below 0.8 keV. We interpret this extended structure as an expanding nebula powered by the wind of ULX1. Its diameter of about 200 pc, characteristic energy of ~1.9 keV and luminosity of ~2 × 1038 erg s−1 imply a mechanical power of 1.3 × 1041 erg s−1 and an age of ~7 × 104 yr. This interpretation suggests that a genuinely super-Eddington regime can be sustained for timescales much longer than the spin-up time of the neutron star powering the system. As the mechanical power from a single ULX nebula can rival the injection rate of cosmic rays of an entire galaxy8, ULX nebulae could be important cosmic ray accelerators9.

Temporal variability in flux and spectral shape is ubiquitous in the X-ray sky and carries crucial information about the nature and emission physics of the sources. The EPIC instrument on board the XMM-Newton observatory is the most powerful tool for studying variability even in faint sources. Each day, it collects a large amount of information about hundreds of new serendipitous sources, but the resulting huge (and growing) dataset is largely unexplored in the time domain. The project called Exploring the X-ray transient and variable sky (EXTraS) systematically extracted all temporal domain information in the XMM-Newton archive. This included a search and characterisation of variability, both periodic and aperiodic, in hundreds of thousands of sources spanning more than eight orders of magnitude in timescale and six orders of magnitude in flux, and a search for fast transients that were missed by standard image analysis. All results, products, and software tools have been released to the community in a public archive. A science gateway has also been implemented to allow users to run the EXTraS analysis remotely on recent XMM datasets. We give details on the new algorithms that were designed and implemented to perform all steps of EPIC data analysis, including data preparation, source and background modelling, generation of time series and power spectra, and search for and characterisation of different types of variabilities. We describe our results and products and give information about their basic statistical properties and advice on their usage. We also describe available online resources. The EXTraS database of results and its ancillary products is a rich resource for any kind of investigation in almost all fields of astrophysics. Algorithms and lessons learnt from our project are also a very useful reference for any current and future experiment in the time domain., Comment: 39 pages; accepted for publication in Astronomy & Astrophysics

Temporal variability in flux and spectral shape is ubiquitous in the X-ray sky and carries crucial information about the nature and emission physics of the sources. The EPIC instrument on board the XMM-Newton observatory is the most powerful tool for studying variability even in faint sources. Each day, it collects a large amount of information about hundreds of new serendipitous sources, but the resulting huge (and growing) dataset is largely unexplored in the time domain. The project called Exploring the X-ray transient and variable sky (EXTraS) systematically extracted all temporal domain information in the XMM-Newton archive. This included a search and characterisation of variability, both periodic and aperiodic, in hundreds of thousands of sources spanning more than eight orders of magnitude in timescale and six orders of magnitude in flux, and a search for fast transients that were missed by standard image analysis. All results, products, and software tools have been released to the community in a public archive. A science gateway has also been implemented to allow users to run the EXTraS analysis remotely on recent XMM datasets. We give details on the new algorithms that were designed and implemented to perform all steps of EPIC data analysis, including data preparation, source and background modelling, generation of time series and power spectra, and search for and characterisation of different types of variabilities. We describe our results and products and give information about their basic statistical properties and advice on their usage. We also describe available online resources. The EXTraS database of results and its ancillary products is a rich resource for any kind of investigation in almost all fields of astrophysics. Algorithms and lessons learnt from our project are also a very useful reference for any current and future experiment in the time domain., Comment: 39 pages; accepted for publication in Astronomy & Astrophysics

We report on our observing campaign of the compact binary merger GW190814, detected by the Advanced LIGO and Advanced Virgo detectors on August 14th, 2019. This signal has the best localisation of any observed gravitational wave (GW) source, with a 90% probability area of 18.5 deg$^2$, and an estimated distance of ~ 240 Mpc. We obtained wide-field observations with the Deca-Degree Optical Transient Imager (DDOTI) covering 88% of the probability area down to a limiting magnitude of $w$ = 19.9 AB. Nearby galaxies within the high probability region were targeted with the Lowell Discovery Telescope (LDT), whereas promising candidate counterparts were characterized through multi-colour photometry with the Reionization and Transients InfraRed (RATIR) and spectroscopy with the Gran Telescopio de Canarias (GTC). We use our optical and near-infrared limits in conjunction with the upper limits obtained by the community to constrain the possible electromagnetic counterparts associated with the merger. A gamma-ray burst seen along its jet's axis is disfavoured by the multi-wavelength dataset, whereas the presence of a burst seen at larger viewing angles is not well constrained. Although our observations are not sensitive to a kilonova similar to AT2017gfo, we can rule out high-mass (> 0.1 M$_{\odot}$) fast-moving (mean velocity >= 0.3c) wind ejecta for a possible kilonova associated with this merger., Comment: 17 pages, 11 figures, 5 tables; updated acknowledgement section. Accepted for publication in MNRAS (10 September 2020)

Long-duration gamma-ray bursts (GRBs) originate from ultra-relativistic jets launched from the collapsing cores of dying massive stars. They are characterised by an initial phase of bright and highly variable radiation in the keV-MeV band that is likely produced within the jet and lasts from milliseconds to minutes, known as the prompt emission. Subsequently, the interaction of the jet with the external medium generates external shock waves, responsible for the afterglow emission, which lasts from days to months, and occurs over a broad energy range, from the radio to the GeV bands. The afterglow emission is generally well explained as synchrotron radiation by electrons accelerated at the external shock. Recently, an intense, long-lasting emission between 0.2 and 1 TeV was observed from the GRB 190114C. Here we present the results of our multi-frequency observational campaign of GRB~190114C, and study the evolution in time of the GRB emission across 17 orders of magnitude in energy, from $5\times10^{-6}$ up to $10^{12}$\,eV. We find that the broadband spectral energy distribution is double-peaked, with the TeV emission constituting a distinct spectral component that has power comparable to the synchrotron component. This component is associated with the afterglow, and is satisfactorily explained by inverse Compton upscattering of synchrotron photons by high-energy electrons. We find that the conditions required to account for the observed TeV component are not atypical, supporting the possibility that inverse Compton emission is commonly produced in GRBs.

The wealth of detections of millisecond pulsars (MSPs) in $\gamma$-rays by {\em Fermi} has spurred searches for these objects among the several unidentified $\gamma$-ray sources. Interesting targets are a sub-class of binary MSPs, dubbed "Black Widows" (BWs) and "Redbacks" (RBs), which are in orbit with low-mass non-degenerate companions fully or partially ablated by irradiation from the MSP wind. These systems can be easily missed in radio pulsar surveys owing to the eclipse of the radio signal by the intra-binary plasma from the ablated companion star photosphere, making them better targets for multi-wavelength observations. We used optical and X-ray data from public databases to carry out a systematic investigation of all the unidentified $\gamma$-ray sources from the Fermi Large Area Telescope (LAT) Third Source Catalog (3FGL), which have been pre-selected as likely MSP candidates according to a machine-learning technique analysis. We tested our procedure by recovering known binary BW/RB identifications and searched for new ones, finding possible candidates. At the same time, we investigated previously proposed BW/RB identifications and we ruled out one of them based upon the updated $\gamma$-ray source coordinates., Comment: 22 pages, 14 figures, 21 pages - This manuscript is based on the MSc Thesis work of C. Braglia, defended on April 2020 at the University of Milan, accepted for publication in MNRAS

During a search for X-ray transients in the XMM-Newton archive within the EXTraS project, we discovered a new X-ray source that is detected only during a ~5 min interval of a ~21 h-long observation performed on 2011 June 21 (EXMM 023135.0-603743, probability of a random Poissonian fluctuation: ~$1.4\times10^{-27}$). With dedicated follow-up observations, we found that its position is consistent with a star-forming galaxy (SFR = 1-2 $M_\odot$ yr$^{-1}$) at redshift $z=0.092\pm0.003$ ($d=435\pm15$ Mpc). At this redshift, the energy released during the transient event was $2.8\times10^{46}$ erg in the 0.3-10 keV energy band (in the source rest frame). The luminosity of the transient, together with its spectral and timing properties, make EXMM 023135.0-603743 a gripping analog to the X-ray transient associated to SN 2008D, which was discovered during a Swift/XRT observation of the nearby ($d=27$ Mpc) supernova-rich galaxy NGC 2770. We interpret the XMM-Newton event as a supernova shock break-out or an early cocoon, and show that our serendipitous discovery is compatible with the rate of core-collapse supernovae derived from optical observations and much higher than that of tidal disruption events., Comment: 11 pages, 6 figures; Revised version accepted for publication in The Astrophysical Journal

We present the first detection of an X-ray flare from an ultracool dwarf of spectral class L. The event was identified in the EXTraS database of XMM-Newton variable sources, and its optical counterpart, J0331-27, was found through a cross-match with the Dark Energy Survey Year 3 release. Next to an earlier four-photon detection of Kelu-1, J0331-27 is only the second L dwarf detected in X-rays, and much more distant than other ultracool dwarfs with X-ray detections (photometric distance of 240 pc). From an optical spectrum with the VIMOS instrument at the VLT, we determine the spectral type of J0331-27 to be L1. The X-ray flare has an energy of E_X,F ~ 2x10^33 erg, placing it in the regime of superflares. No quiescent emission is detected, and from 2.5 Msec of XMM data we derive an upper limit of L_X,qui < 10^27 erg/s. The flare peak luminosity L_X,peak = 6.3x10^29 erg/s, flare duration tau_decay ~ 2400 s, and plasma temperature (~16 MK) are similar to values observed in X-ray flares of M dwarfs. This shows that strong magnetic reconnection events and the ensuing plasma heating are still present even in objects with photospheres as cool as ~2100 K. However, the absence of any other flares above the detection threshold of E_X,F ~2.5x10^32 erg in a total of ~2.5 Ms of X-ray data yields a flare energy number distribution inconsistent with the canonical power law dN/dE ~ E^-2, suggesting that magnetic energy release in J0331-27 -- and possibly in all L dwarfs -- takes place predominantly in the form of giant flares., Comment: 5 pages, 3 figures. Published as a Letter to A&A

We report on our observing campaign of the compact binary merger GW190814, detected by the Advanced LIGO and Advanced Virgo detectors on August 14th, 2019. This signal has the best localisation of any observed gravitational wave (GW) source, with a 90% probability area of 18.5 deg$^2$, and an estimated distance of ~ 240 Mpc. We obtained wide-field observations with the Deca-Degree Optical Transient Imager (DDOTI) covering 88% of the probability area down to a limiting magnitude of $w$ = 19.9 AB. Nearby galaxies within the high probability region were targeted with the Lowell Discovery Telescope (LDT), whereas promising candidate counterparts were characterized through multi-colour photometry with the Reionization and Transients InfraRed (RATIR) and spectroscopy with the Gran Telescopio de Canarias (GTC). We use our optical and near-infrared limits in conjunction with the upper limits obtained by the community to constrain the possible electromagnetic counterparts associated with the merger. A gamma-ray burst seen along its jet's axis is disfavoured by the multi-wavelength dataset, whereas the presence of a burst seen at larger viewing angles is not well constrained. Although our observations are not sensitive to a kilonova similar to AT2017gfo, we can rule out high-mass (> 0.1 M$_{\odot}$) fast-moving (mean velocity >= 0.3c) wind ejecta for a possible kilonova associated with this merger., Comment: 17 pages, 11 figures, 5 tables; updated acknowledgement section. Accepted for publication in MNRAS (10 September 2020)

The wealth of detections of millisecond pulsars (MSPs) in $\gamma$-rays by {\em Fermi} has spurred searches for these objects among the several unidentified $\gamma$-ray sources. Interesting targets are a sub-class of binary MSPs, dubbed "Black Widows" (BWs) and "Redbacks" (RBs), which are in orbit with low-mass non-degenerate companions fully or partially ablated by irradiation from the MSP wind. These systems can be easily missed in radio pulsar surveys owing to the eclipse of the radio signal by the intra-binary plasma from the ablated companion star photosphere, making them better targets for multi-wavelength observations. We used optical and X-ray data from public databases to carry out a systematic investigation of all the unidentified $\gamma$-ray sources from the Fermi Large Area Telescope (LAT) Third Source Catalog (3FGL), which have been pre-selected as likely MSP candidates according to a machine-learning technique analysis. We tested our procedure by recovering known binary BW/RB identifications and searched for new ones, finding possible candidates. At the same time, we investigated previously proposed BW/RB identifications and we ruled out one of them based upon the updated $\gamma$-ray source coordinates., Comment: 22 pages, 14 figures, 21 pages - This manuscript is based on the MSc Thesis work of C. Braglia, defended on April 2020 at the University of Milan, accepted for publication in MNRAS

Long-duration gamma-ray bursts (GRBs) originate from ultra-relativistic jets launched from the collapsing cores of dying massive stars. They are characterised by an initial phase of bright and highly variable radiation in the keV-MeV band that is likely produced within the jet and lasts from milliseconds to minutes, known as the prompt emission. Subsequently, the interaction of the jet with the external medium generates external shock waves, responsible for the afterglow emission, which lasts from days to months, and occurs over a broad energy range, from the radio to the GeV bands. The afterglow emission is generally well explained as synchrotron radiation by electrons accelerated at the external shock. Recently, an intense, long-lasting emission between 0.2 and 1 TeV was observed from the GRB 190114C. Here we present the results of our multi-frequency observational campaign of GRB~190114C, and study the evolution in time of the GRB emission across 17 orders of magnitude in energy, from $5\times10^{-6}$ up to $10^{12}$\,eV. We find that the broadband spectral energy distribution is double-peaked, with the TeV emission constituting a distinct spectral component that has power comparable to the synchrotron component. This component is associated with the afterglow, and is satisfactorily explained by inverse Compton upscattering of synchrotron photons by high-energy electrons. We find that the conditions required to account for the observed TeV component are not atypical, supporting the possibility that inverse Compton emission is commonly produced in GRBs.

During a search for X-ray transients in the XMM-Newton archive within the EXTraS project, we discovered a new X-ray source that is detected only during a ~5 min interval of a ~21 h-long observation performed on 2011 June 21 (EXMM 023135.0-603743, probability of a random Poissonian fluctuation: ~$1.4\times10^{-27}$). With dedicated follow-up observations, we found that its position is consistent with a star-forming galaxy (SFR = 1-2 $M_\odot$ yr$^{-1}$) at redshift $z=0.092\pm0.003$ ($d=435\pm15$ Mpc). At this redshift, the energy released during the transient event was $2.8\times10^{46}$ erg in the 0.3-10 keV energy band (in the source rest frame). The luminosity of the transient, together with its spectral and timing properties, make EXMM 023135.0-603743 a gripping analog to the X-ray transient associated to SN 2008D, which was discovered during a Swift/XRT observation of the nearby ($d=27$ Mpc) supernova-rich galaxy NGC 2770. We interpret the XMM-Newton event as a supernova shock break-out or an early cocoon, and show that our serendipitous discovery is compatible with the rate of core-collapse supernovae derived from optical observations and much higher than that of tidal disruption events., Comment: 11 pages, 6 figures; Revised version accepted for publication in The Astrophysical Journal

We present the first detection of an X-ray flare from an ultracool dwarf of spectral class L. The event was identified in the EXTraS database of XMM-Newton variable sources, and its optical counterpart, J0331-27, was found through a cross-match with the Dark Energy Survey Year 3 release. Next to an earlier four-photon detection of Kelu-1, J0331-27 is only the second L dwarf detected in X-rays, and much more distant than other ultracool dwarfs with X-ray detections (photometric distance of 240 pc). From an optical spectrum with the VIMOS instrument at the VLT, we determine the spectral type of J0331-27 to be L1. The X-ray flare has an energy of E_X,F ~ 2x10^33 erg, placing it in the regime of superflares. No quiescent emission is detected, and from 2.5 Msec of XMM data we derive an upper limit of L_X,qui < 10^27 erg/s. The flare peak luminosity L_X,peak = 6.3x10^29 erg/s, flare duration tau_decay ~ 2400 s, and plasma temperature (~16 MK) are similar to values observed in X-ray flares of M dwarfs. This shows that strong magnetic reconnection events and the ensuing plasma heating are still present even in objects with photospheres as cool as ~2100 K. However, the absence of any other flares above the detection threshold of E_X,F ~2.5x10^32 erg in a total of ~2.5 Ms of X-ray data yields a flare energy number distribution inconsistent with the canonical power law dN/dE ~ E^-2, suggesting that magnetic energy release in J0331-27 -- and possibly in all L dwarfs -- takes place predominantly in the form of giant flares., Comment: 5 pages, 3 figures. Published as a Letter to A&A

Long-duration gamma-ray bursts (GRBs) originate from ultra-relativistic jets launched from the collapsing cores of dying massive stars. They are characterized by an initial phase of bright and highly variable radiation in the kiloelectron volt-to-mega electronvoltband, which is probably produced within the jet and lasts from milliseconds to minutes, known as the prompt emission(1,2). Subsequently, the interaction of the jet with the surrounding medium generates shock waves that are responsible for the afterglow emission, which lasts from days to months and occurs over a broad energy range from the radio to the gigaelectronvolt bands(1-6). The afterglow emission is generally well explained as synchrotron radiation emitted by electrons accelerated by the external shock(7-9). Recently, intense long-lasting emission between 0.2 and 1 teraelectronvolts was observed from GRB 190114C(10,11). Here we report multifrequency observations of GRB 190114C, and study the evolution in time of the GRB emission across 17 orders of magnitude in energy, from 5 x 10(-6) to 10(12) electronvolts. We find that the broadband spectral energy distribution is double-peaked, with the teraelectronvolt emission constituting a distinct spectral component with power comparable to the synchrotron component. This component is associated with the afterglow and is satisfactorily explained by inverse Compton up-scattering of synchrotron photons by high-energy electrons. We find that the conditions required to account for the observed teraelectronvolt component are typical for GRBs, supporting the possibility that inverse Compton emission is commonly produced in GRBs., QC 20191217

Long-duration γ-ray bursts (GRBs) originate from ultra-relativistic jets launched from the collapsing cores of dying massive stars. They are characterized by an initial phase of bright and highly variable radiation in the kiloelectronvolt-to-megaelectronvolt band, which is probably produced within the jet and lasts from milliseconds to minutes, known as the prompt emission1,2. Subsequently, the interaction of the jet with the surrounding medium generates shock waves that are responsible for the afterglow emission, which lasts from days to months and occurs over a broad energy range from the radio to the gigaelectronvolt bands1,2,3,4,5,6. The afterglow emission is generally well explained as synchrotron radiation emitted by electrons accelerated by the external shock7,8,9. Recently, intense long-lasting emission between 0.2 and 1 teraelectronvolts was observed from GRB 190114C10,11. Here we report multi-frequency observations of GRB 190114C, and study the evolution in time of the GRB emission across 17 orders of magnitude in energy, from 5 × 10−6 to 1012 electronvolts. We find that the broadband spectral energy distribution is double-peaked, with the teraelectronvolt emission constituting a distinct spectral component with power comparable to the synchrotron component. This component is associated with the afterglow and is satisfactorily explained by inverse Compton up-scattering of synchrotron photons by high-energy electrons. We find that the conditions required to account for the observed teraelectronvolt component are typical for GRBs, supporting the possibility that inverse Compton emission is commonly produced in GRBs.

Item does not contain fulltext, CONTEXT: Several drugs are approved and available for the treatment of lower urinary tract symptoms (LUTS) in men and women. However, the vast majority of available data, upon which the approval and recommendation in guidelines are based, considered only the role of the monotherapies and did not evaluate possible combination therapies. OBJECTIVE: This systematic review analyzes the efficacy and adverse events of combination therapies for male and female LUTS. EVIDENCE ACQUISITION: A systematic literature search in the PubMed/Medline, Web of Science, and Cochrane databases was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-analysis statement to identify clinical trials, randomized controlled trials, meta-analyses, and guidelines on male and female LUTS combination therapy published from March 2012 to December 2017 for men (in order to update a previous men-focused work) and from January 1988 to December 2017 for women. A total of 58 papers were identified. EVIDENCE SYNTHESIS: The most studied combination therapy for the treatment of male LUTS is the alpha1-adrenoceptor antagonist/5alpha-reductase inhibitor combination. This combination seems to be more efficacious in terms of several outcome variables, in particular in men who have moderate-to-severe LUTS and are at risk of disease progression. Also in terms of nocturia improvements, this combination is significantly more effective than the monotherapy. The other often studied combination treatment, in both male and female patients with LUTS, was the combination of antimuscarinics (in particular solifenacin) and mirabegron. This combination seems to be more effective in comparison with the monotherapies with respect to urinary incontinence and urgency urinary incontinence episodes and several other objective and subjective parameters, without relevant increase of adverse events. The combination of hormone therapy and antimuscarinics in women with LUTS does not seem to be useful.

GRB 160821B is a short duration gamma-ray burst (GRB) detected and localized by the Neil Gehrels Swift Observatory in the outskirts of a spiral galaxy at z=0.1613, at a projected physical offset of 16 kpc from the galaxy's center. We present X-ray, optical/nIR and radio observations of its counterpart and model them with two distinct components of emission: a standard afterglow, arising from the interaction of the relativistic jet with the surrounding medium, and a kilonova, powered by the radioactive decay of the sub-relativistic ejecta. Broadband modeling of the afterglow data reveals a weak reverse shock propagating backward into the jet, and a likely jet-break at 3.5 d. This is consistent with a structured jet seen slightly off-axis while expanding into a low-density medium. Analysis of the kilonova properties suggests a rapid evolution toward red colors, similar to AT2017gfo, and a low nIR luminosity, possibly due to the presence of a long-lived neutron star. The global properties of the environment, the inferred low mass (M_ej < 0.006 Msun) and velocities (v > 0.05 c) of lanthanide-rich ejecta are consistent with a binary neutron star merger progenitor., Comment: 14 pages, 6 figures, MNRAS, in press. Moderate revision, added Figure 5 and X-ray data to Table 1

Item does not contain fulltext, CONTEXT: Several drugs are approved and available for the treatment of lower urinary tract symptoms (LUTS) in men and women. However, the vast majority of available data, upon which the approval and recommendation in guidelines are based, considered only the role of the monotherapies and did not evaluate possible combination therapies. OBJECTIVE: This systematic review analyzes the efficacy and adverse events of combination therapies for male and female LUTS. EVIDENCE ACQUISITION: A systematic literature search in the PubMed/Medline, Web of Science, and Cochrane databases was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-analysis statement to identify clinical trials, randomized controlled trials, meta-analyses, and guidelines on male and female LUTS combination therapy published from March 2012 to December 2017 for men (in order to update a previous men-focused work) and from January 1988 to December 2017 for women. A total of 58 papers were identified. EVIDENCE SYNTHESIS: The most studied combination therapy for the treatment of male LUTS is the alpha1-adrenoceptor antagonist/5alpha-reductase inhibitor combination. This combination seems to be more efficacious in terms of several outcome variables, in particular in men who have moderate-to-severe LUTS and are at risk of disease progression. Also in terms of nocturia improvements, this combination is significantly more effective than the monotherapy. The other often studied combination treatment, in both male and female patients with LUTS, was the combination of antimuscarinics (in particular solifenacin) and mirabegron. This combination seems to be more effective in comparison with the monotherapies with respect to urinary incontinence and urgency urinary incontinence episodes and several other objective and subjective parameters, without relevant increase of adverse events. The combination of hormone therapy and antimuscarinics in women with LUTS does not seem to be useful.

Item does not contain fulltext, CONTEXT: Several drugs are approved and available for the treatment of lower urinary tract symptoms (LUTS) in men and women. However, the vast majority of available data, upon which the approval and recommendation in guidelines are based, considered only the role of the monotherapies and did not evaluate possible combination therapies. OBJECTIVE: This systematic review analyzes the efficacy and adverse events of combination therapies for male and female LUTS. EVIDENCE ACQUISITION: A systematic literature search in the PubMed/Medline, Web of Science, and Cochrane databases was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-analysis statement to identify clinical trials, randomized controlled trials, meta-analyses, and guidelines on male and female LUTS combination therapy published from March 2012 to December 2017 for men (in order to update a previous men-focused work) and from January 1988 to December 2017 for women. A total of 58 papers were identified. EVIDENCE SYNTHESIS: The most studied combination therapy for the treatment of male LUTS is the alpha1-adrenoceptor antagonist/5alpha-reductase inhibitor combination. This combination seems to be more efficacious in terms of several outcome variables, in particular in men who have moderate-to-severe LUTS and are at risk of disease progression. Also in terms of nocturia improvements, this combination is significantly more effective than the monotherapy. The other often studied combination treatment, in both male and female patients with LUTS, was the combination of antimuscarinics (in particular solifenacin) and mirabegron. This combination seems to be more effective in comparison with the monotherapies with respect to urinary incontinence and urgency urinary incontinence episodes and several other objective and subjective parameters, without relevant increase of adverse events. The combination of hormone therapy and antimuscarinics in women with LUTS does not seem to be useful.

GRB 160821B is a short duration gamma-ray burst (GRB) detected and localized by the Neil Gehrels Swift Observatory in the outskirts of a spiral galaxy at z=0.1613, at a projected physical offset of 16 kpc from the galaxy's center. We present X-ray, optical/nIR and radio observations of its counterpart and model them with two distinct components of emission: a standard afterglow, arising from the interaction of the relativistic jet with the surrounding medium, and a kilonova, powered by the radioactive decay of the sub-relativistic ejecta. Broadband modeling of the afterglow data reveals a weak reverse shock propagating backward into the jet, and a likely jet-break at 3.5 d. This is consistent with a structured jet seen slightly off-axis while expanding into a low-density medium. Analysis of the kilonova properties suggests a rapid evolution toward red colors, similar to AT2017gfo, and a low nIR luminosity, possibly due to the presence of a long-lived neutron star. The global properties of the environment, the inferred low mass (M_ej < 0.006 Msun) and velocities (v > 0.05 c) of lanthanide-rich ejecta are consistent with a binary neutron star merger progenitor., Comment: 14 pages, 6 figures, MNRAS, in press. Moderate revision, added Figure 5 and X-ray data to Table 1

GRB 160821B is a short duration gamma-ray burst (GRB) detected and localized by the Neil Gehrels Swift Observatory in the outskirts of a spiral galaxy at z = 0.1613, at a projected physical offset of 16 kpc from the galaxy's center. We present X-ray, optical/nIR, and radio observations of its counterpart and model them with two distinct components of emission: a standard afterglow, arising from the interaction of the relativistic jet with the surrounding medium, and a kilonova, powered by the radioactive decay of the sub-relativistic ejecta. Broadband modelling of the afterglow data reveals a weak reverse shock propagating backward into the jet, and a likely jet-break at 3.5 d. This is consistent with a structured jet seen slightly off-axis (theta(view) similar to theta(core)) while expanding into a low-density medium (n approximate to 10(-3) cm(-3)). Analysis of the kilonova properties suggests a rapid evolution towards red colours, similar to AT2017gfo, and a low-nIR luminosity, possibly due to the presence of a long-lived neutron star. The global properties of the environment, the inferred low mass (M-ej less than or similar to 0.006 M-circle dot) and velocities (v(ej) greater than or similar to 0.05c) of lanthanide-rich ejecta are consistent with a binary neutron star merger progenitor.© 2019 The Authors.

Multi-messenger observations of GW170817 have not conclusively established whether the merger remnant is a black hole (BH) or a neutron star (NS). We show that a long-lived magnetized NS with a poloidal field $B\approx 10^{12}$G is fully consistent with the electromagnetic dataset, when spin down losses are dominated by gravitational wave (GW) emission. The required ellipticity $\epsilon\gtrsim 10^{-5}$ can result from a toroidal magnetic field component much stronger than the poloidal component, a configuration expected from a NS newly formed from a merger. Abrupt magnetic dissipation of the toroidal component can lead to the appearance of X-ray flares, analogous to the one observed in gamma-ray burst (GRB) afterglows. In the X-ray afterglow of GW170817 we identify a low-significance ($\gtrsim 3\sigma$) temporal feature at 155 d, consistent with a sudden reactivation of the central NS. Energy injection from the NS spin down into the relativistic shock is negligible, and the underlying continuum is fully accounted for by a structured jet seen off-axis. Whereas radio and optical observations probe the interaction of this jet with the surrounding medium, observations at X-ray wavelengths, performed with adequate sampling, open a privileged window on to the merger remnant., Comment: 10 pages, 7 figs, MNRAS Accepted 2018 November 5

We report on the serendipitous discovery of a new transient in NGC 5907, at a peak luminosity of 6.4x10^{39} erg/s. The source was undetected in previous 2012 Chandra observations with a 3 sigma upper limit on the luminosity of 1.5x10^{38} erg/s, implying a flux increase of a factor of >35. We analyzed three recent 60ks/50ks Chandra and 50ks XMM-Newton observations, as well as all the available Swift observations performed between August 2017/March 2018. Until the first half of October 2017, Swift observations do not show any emission from the source. The transient entered the ULX regime in less than two weeks and its outburst was still on-going at the end of February 2018. The 0.3-10 keV spectrum is consistent with a single multicolour blackbody disc (kT~1.5 keV). The source might be a ~30 solar mass black hole accreting at the Eddington limit. However, although we did not find evidence of pulsations, we cannot rule-out the possibility that this ULX hosts an accreting neutron star., Comment: Accepted on MNRAS, 5 pages, 2 figure, 1 table

Multi-messenger observations of GW170817 have not conclusively established whether the merger remnant is a black hole (BH) or a neutron star (NS). We show that a long-lived magnetized NS with a poloidal field $B\approx 10^{12}$G is fully consistent with the electromagnetic dataset, when spin down losses are dominated by gravitational wave (GW) emission. The required ellipticity $\epsilon\gtrsim 10^{-5}$ can result from a toroidal magnetic field component much stronger than the poloidal component, a configuration expected from a NS newly formed from a merger. Abrupt magnetic dissipation of the toroidal component can lead to the appearance of X-ray flares, analogous to the one observed in gamma-ray burst (GRB) afterglows. In the X-ray afterglow of GW170817 we identify a low-significance ($\gtrsim 3\sigma$) temporal feature at 155 d, consistent with a sudden reactivation of the central NS. Energy injection from the NS spin down into the relativistic shock is negligible, and the underlying continuum is fully accounted for by a structured jet seen off-axis. Whereas radio and optical observations probe the interaction of this jet with the surrounding medium, observations at X-ray wavelengths, performed with adequate sampling, open a privileged window on to the merger remnant., Comment: 10 pages, 7 figs, MNRAS Accepted 2018 November 5

We report on the serendipitous discovery of a new transient in NGC 5907, at a peak luminosity of 6.4x10^{39} erg/s. The source was undetected in previous 2012 Chandra observations with a 3 sigma upper limit on the luminosity of 1.5x10^{38} erg/s, implying a flux increase of a factor of >35. We analyzed three recent 60ks/50ks Chandra and 50ks XMM-Newton observations, as well as all the available Swift observations performed between August 2017/March 2018. Until the first half of October 2017, Swift observations do not show any emission from the source. The transient entered the ULX regime in less than two weeks and its outburst was still on-going at the end of February 2018. The 0.3-10 keV spectrum is consistent with a single multicolour blackbody disc (kT~1.5 keV). The source might be a ~30 solar mass black hole accreting at the Eddington limit. However, although we did not find evidence of pulsations, we cannot rule-out the possibility that this ULX hosts an accreting neutron star., Comment: Accepted on MNRAS, 5 pages, 2 figure, 1 table

OBJECTIVES: To evaluate and compare the correlations between Preoperative Aspects and Dimensions Used for an Anatomical (PADUA) and R.E.N.A.L. [Radius (tumour size as maximal diameter), Exophytic/endophytic properties of the tumour, Nearness of tumour deepest portion to the collecting system or sinus, Anterior (a)/posterior (p) descriptor and the Location relative to the polar line] nephrometry scores and perioperative outcomes and postoperative complications in a multicentre, international series of patients undergoing robot-assisted partial nephrectomy (RAPN) for masses suspicious for renal cell carcinoma (RCC). PATIENTS AND METHODS: We retrospectively evaluated the clinical records of patients who underwent RAPN between 2010 and 2013 for clinical N0M0 renal tumours in four international centres that completed all the data required for the Vattikuti Global Quality Initiative in Robotic Urologic Surgery (GQI-RUS) database. All patients underwent preoperative computed tomography or magnetic resonance imaging to define the clinical stage and anatomical characteristics of the tumours. PADUA and R.E.N.A.L. scores were retrospectively assessed in each centre. Univariate and multivariate analyses were used to evaluate the correlations between age, gender, Charlson comorbidity index, clinical tumour size, PADUA and R.E.N.A.L. complexity group categories and warm ischaemia time (WIT) of >20 min, urinary calyceal system closure, and grade of postoperative complications. RESULTS: Overall, 277 patients were evaluated. The median (interquartile range) tumour size was 33.0 (22.0-43.0) mm. The median PADUA and R.E.N.A.L. scores were eight and seven, respectively; 112 (40.4%), 86 (31.0%) and 79 (28.5%) patients were classified in the low-, intermediate- or high-complexity group according to PADUA score, while 118 (42.5%), 139 (50.1%) and 20 (7.2%) were classified in the low-, intermediate- or high-complexity group according to R.E.N.A.L. score, respectively. Both nephrometry tool

The EXTraS project to explore the X-ray Transient and variable Sky searches for coherent signals in the X-ray archival data of XMM-Newton. XMM-Newton performed more than 400 pointed observations in the region of the Large Magellanic Cloud (LMC). We inspected the results of the EXTraS period search to systematically look for new X-ray pulsators in our neighbour galaxy. We analysed the XMM-Newton observations of two sources from the 3XMM catalogue which show significant signals for coherent pulsations. 3XMM J051259.8-682640 was detected as source with hard X-ray spectrum in two XMM-Newton observations, revealing a periodic modulation of the X-ray flux with 956~s. As optical counterpart we identify an early-type star with Halpha emission. The OGLE I-band light curve exhibits a regular pattern with three brightness dips which mark a period of ~1350 d. The X-ray spectrum of 3XMM J051034.6-670353 is dominated by a super-soft blackbody-like emission component (kT ~ 70 eV) which is modulated by nearly 100% with a period of ~1418 s. From GROND observations we suggest a star with r' = 20.9 mag as possible counterpart of the X-ray source. 3XMM J051259.8-682640 is confirmed as a new Be/X-ray binary pulsar in the Large Magellanic Cloud. We discuss the long-term optical period as likely orbital period which would be the longest known from a high-mass X-ray binary. The spectral and temporal properties of the super-soft source 3XMM J051034.6-670353 are very similar to those of RX J0806.3+1527 and RX J1914.4+2456 suggesting that it belongs to the class of double-degenerate polars and is located in our Galaxy rather than in the LMC., Comment: 10 pages, 13 figures, accepted for publication in Astronomy & Astrophysics, new version with minor corrections

Ultraluminous x-ray sources (ULXs) in nearby galaxies shine brighter than any X-ray source in our Galaxy. ULXs are usually modeled as stellar-mass black holes (BHs) accreting at very high rates or intermediate-mass BHs. We present observations showing that NGC5907 ULX is instead an x-ray accreting neutron star (NS) with a spin period evolving from 1.43~s in 2003 to 1.13~s in 2014. It has an isotropic peak luminosity of about 1000 times the Eddington limit for a NS at 17.1~Mpc. Standard accretion models fail to explain its luminosity, even assuming beamed emission, but a strong multipolar magnetic field can describe its properties. These findings suggest that other extreme ULXs (x-ray luminosity > 10^{41} erg/s) might harbor NSs., Comment: 37 pages including Supplementary Material; 7 figures

The EXTraS project to explore the X-ray Transient and variable Sky searches for coherent signals in the X-ray archival data of XMM-Newton. XMM-Newton performed more than 400 pointed observations in the region of the Large Magellanic Cloud (LMC). We inspected the results of the EXTraS period search to systematically look for new X-ray pulsators in our neighbour galaxy. We analysed the XMM-Newton observations of two sources from the 3XMM catalogue which show significant signals for coherent pulsations. 3XMM J051259.8-682640 was detected as source with hard X-ray spectrum in two XMM-Newton observations, revealing a periodic modulation of the X-ray flux with 956~s. As optical counterpart we identify an early-type star with Halpha emission. The OGLE I-band light curve exhibits a regular pattern with three brightness dips which mark a period of ~1350 d. The X-ray spectrum of 3XMM J051034.6-670353 is dominated by a super-soft blackbody-like emission component (kT ~ 70 eV) which is modulated by nearly 100% with a period of ~1418 s. From GROND observations we suggest a star with r' = 20.9 mag as possible counterpart of the X-ray source. 3XMM J051259.8-682640 is confirmed as a new Be/X-ray binary pulsar in the Large Magellanic Cloud. We discuss the long-term optical period as likely orbital period which would be the longest known from a high-mass X-ray binary. The spectral and temporal properties of the super-soft source 3XMM J051034.6-670353 are very similar to those of RX J0806.3+1527 and RX J1914.4+2456 suggesting that it belongs to the class of double-degenerate polars and is located in our Galaxy rather than in the LMC., Comment: 10 pages, 13 figures, accepted for publication in Astronomy & Astrophysics, new version with minor corrections

Ultraluminous x-ray sources (ULXs) in nearby galaxies shine brighter than any X-ray source in our Galaxy. ULXs are usually modeled as stellar-mass black holes (BHs) accreting at very high rates or intermediate-mass BHs. We present observations showing that NGC5907 ULX is instead an x-ray accreting neutron star (NS) with a spin period evolving from 1.43~s in 2003 to 1.13~s in 2014. It has an isotropic peak luminosity of about 1000 times the Eddington limit for a NS at 17.1~Mpc. Standard accretion models fail to explain its luminosity, even assuming beamed emission, but a strong multipolar magnetic field can describe its properties. These findings suggest that other extreme ULXs (x-ray luminosity > 10^{41} erg/s) might harbor NSs., Comment: 37 pages including Supplementary Material; 7 figures

During a search for coherent signals in the X-ray archival data of XMM-Newton, we discovered a modulation at 1.2 s in 3XMM J004301.4+413017 (3X J0043), a source lying in the direction of an external arm of M 31. This short period indicates a neutron star (NS). Between 2000 and 2013, the position of 3X J0043 was imaged by public XMM-Newton observations 35 times. The analysis of these data allowed us to detect an orbital modulation at 1.27 d and study the long-term properties of the source. The emission of the pulsar was rather hard (most spectra are described by a power law with $\Gamma < 1$) and, assuming the distance to M 31, the 0.3-10 keV luminosity was variable, from $\sim$$3\times10^{37}$ to $2\times10^{38}$ erg s$^{-1}$. The analysis of optical data shows that, while 3X J0043 is likely associated to a globular cluster in M 31, a counterpart with $V\gtrsim22$ outside the cluster cannot be excluded. Considering our findings, there are two main viable scenarios for 3X J0043: a peculiar low-mass X-ray binary, similar to 4U 1822-37 or 4U 1626-67, or an intermediate-mass X-ray binary resembling Her X-1. Regardless of the exact nature of the system, 3X J0043 is the first accreting NS in M 31 in which the spin period has been detected., Comment: To appear in MNRAS Letters; 2 color figures, 2 tables; 5 pages plus full Table 1 (1 page)

We report on the results of the first XMM-Newton satellite observation of the luminous and helium-rich O-type subdwarf BD +37{\deg} 1977 carried out in April 2014. X-ray emission is detected with a flux of about 4*10^(-14) erg/cm2/s (0.2-1.5 keV), corresponding to a f_X/f_bol ratio about 10^(-7); the source spectrum is very soft, and is well fit by the sum of two plasma components at different temperatures. Both characteristics are in agreement with what is observed in the main-sequence early-type stars, where the observed X-ray emission is due to turbulence and shocks in the stellar wind. A smaller but still significant stellar wind has been observed also in BD +37{\deg} 1977; therefore, we suggest that also in this case the detected X-ray flux has the same origin., Comment: 6 pages. Accepted for publication by Astronomy and Astrophysics

During a search for coherent signals in the X-ray archival data of XMM-Newton, we discovered a modulation at 1.2 s in 3XMM J004301.4+413017 (3X J0043), a source lying in the direction of an external arm of M 31. This short period indicates a neutron star (NS). Between 2000 and 2013, the position of 3X J0043 was imaged by public XMM-Newton observations 35 times. The analysis of these data allowed us to detect an orbital modulation at 1.27 d and study the long-term properties of the source. The emission of the pulsar was rather hard (most spectra are described by a power law with $\Gamma < 1$) and, assuming the distance to M 31, the 0.3-10 keV luminosity was variable, from $\sim$$3\times10^{37}$ to $2\times10^{38}$ erg s$^{-1}$. The analysis of optical data shows that, while 3X J0043 is likely associated to a globular cluster in M 31, a counterpart with $V\gtrsim22$ outside the cluster cannot be excluded. Considering our findings, there are two main viable scenarios for 3X J0043: a peculiar low-mass X-ray binary, similar to 4U 1822-37 or 4U 1626-67, or an intermediate-mass X-ray binary resembling Her X-1. Regardless of the exact nature of the system, 3X J0043 is the first accreting NS in M 31 in which the spin period has been detected., Comment: To appear in MNRAS Letters; 2 color figures, 2 tables; 5 pages plus full Table 1 (1 page)

We report on the results of the first XMM-Newton satellite observation of the luminous and helium-rich O-type subdwarf BD +37{\deg} 1977 carried out in April 2014. X-ray emission is detected with a flux of about 4*10^(-14) erg/cm2/s (0.2-1.5 keV), corresponding to a f_X/f_bol ratio about 10^(-7); the source spectrum is very soft, and is well fit by the sum of two plasma components at different temperatures. Both characteristics are in agreement with what is observed in the main-sequence early-type stars, where the observed X-ray emission is due to turbulence and shocks in the stellar wind. A smaller but still significant stellar wind has been observed also in BD +37{\deg} 1977; therefore, we suggest that also in this case the detected X-ray flux has the same origin., Comment: 6 pages. Accepted for publication by Astronomy and Astrophysics

Many of the high mass X-ray binaries (HMXRBs) discovered in recent years in our Galaxy are characterized by a high absorption, most likely intrinsic to the system, which hampers their detection at the softest X-ray energies. We have undertaken a search for highly-absorbed X-ray sources in the Small Magellanic Cloud (SMC) with a systematic analysis of 62 XMM-Newton SMC observations. We obtained a sample of 30 sources showing evidence for an equivalent hydrogen column density larger than 3x10^23 cm^-2. Five of these sources are clearly identified as HMXRBs: four were already known (including three X-ray pulsars) and one, XMM J005605.8-720012, reported here for the first time. For the latter, we present optical spectroscopy confirming the association with a Be star in the SMC. The other sources in our sample have optical counterparts fainter than magnitude ~16 in the V band, and many of them have possible NIR counterparts consistent with highly reddened early type stars in the SMC. While their number is broadly consistent with the expected population of background highly-absorbed active galactic nuclei, a few of them could be HMXRBs in which an early type companion is severely reddened by local material., Comment: 10 pages, 4 figures, 4 tables. Accepted for publication by Astronomy & Astrophysics

Many of the high mass X-ray binaries (HMXRBs) discovered in recent years in our Galaxy are characterized by a high absorption, most likely intrinsic to the system, which hampers their detection at the softest X-ray energies. We have undertaken a search for highly-absorbed X-ray sources in the Small Magellanic Cloud (SMC) with a systematic analysis of 62 XMM-Newton SMC observations. We obtained a sample of 30 sources showing evidence for an equivalent hydrogen column density larger than 3x10^23 cm^-2. Five of these sources are clearly identified as HMXRBs: four were already known (including three X-ray pulsars) and one, XMM J005605.8-720012, reported here for the first time. For the latter, we present optical spectroscopy confirming the association with a Be star in the SMC. The other sources in our sample have optical counterparts fainter than magnitude ~16 in the V band, and many of them have possible NIR counterparts consistent with highly reddened early type stars in the SMC. While their number is broadly consistent with the expected population of background highly-absorbed active galactic nuclei, a few of them could be HMXRBs in which an early type companion is severely reddened by local material., Comment: 10 pages, 4 figures, 4 tables. Accepted for publication by Astronomy & Astrophysics

On 2008 May 14, the Burst Alert Telescope aboard the Swift mission triggered on a type-I X-ray burst from the previously unclassified ROSAT object 1RXH J173523.7-354013, establishing the source as a neutron star X-ray binary. We report on X-ray, optical and near-infrared observations of this system. The X-ray burst had a duration of ~2 h and belongs to the class of rare, intermediately long type-I X-ray bursts. From the bolometric peak flux of ~3.5E-8 erg/cm^2/s, we infer a source distance of D<9.5 kpc. Photometry of the field reveals an optical counterpart that declined from R=15.9 during the X-ray burst to R=18.9 thereafter. Analysis of post-burst Swift/XRT observations, as well as archival XMM-Newton and ROSAT data suggests that the system is persistent at a 0.5-10 keV luminosity of ~2E35 (D/9.5 kpc)^2 erg/s. Optical and infrared photometry together with the detection of a narrow Halpha emission line (FWHM=292+/-9 km/s, EW=-9.0+/-0.4 Angstrom) in the optical spectrum confirms that 1RXH J173523.7-354013 is a neutron star low-mass X-ray binary. The Halpha emission demonstrates that the donor star is hydrogen-rich, which effectively rules out that this system is an ultra-compact X-ray binary., Comment: Accepted for publication in MNRAS, 13 pages, 6 figures, 5 tables

On 2008 May 14, the Burst Alert Telescope aboard the Swift mission triggered on a type-I X-ray burst from the previously unclassified ROSAT object 1RXH J173523.7-354013, establishing the source as a neutron star X-ray binary. We report on X-ray, optical and near-infrared observations of this system. The X-ray burst had a duration of ~2 h and belongs to the class of rare, intermediately long type-I X-ray bursts. From the bolometric peak flux of ~3.5E-8 erg/cm^2/s, we infer a source distance of D<9.5 kpc. Photometry of the field reveals an optical counterpart that declined from R=15.9 during the X-ray burst to R=18.9 thereafter. Analysis of post-burst Swift/XRT observations, as well as archival XMM-Newton and ROSAT data suggests that the system is persistent at a 0.5-10 keV luminosity of ~2E35 (D/9.5 kpc)^2 erg/s. Optical and infrared photometry together with the detection of a narrow Halpha emission line (FWHM=292+/-9 km/s, EW=-9.0+/-0.4 Angstrom) in the optical spectrum confirms that 1RXH J173523.7-354013 is a neutron star low-mass X-ray binary. The Halpha emission demonstrates that the donor star is hydrogen-rich, which effectively rules out that this system is an ultra-compact X-ray binary., Comment: Accepted for publication in MNRAS, 13 pages, 6 figures, 5 tables

GRB 090709A is a long gamma-ray burst (GRB) discovered by Swift, featuring a bright X-ray afterglow as well as a faint infrared transient with very red and peculiar colors. The burst attracted a large interest because of a possible quasi-periodicity at P=8.1 s in the prompt emission, suggesting that it could have a different origin with respect to standard, long GRBs. In order to understand the nature of this burst, we obtained a target of opportunity observation with XMM-Newton. X-ray spectroscopy, based on XMM-Newton and Swift data, allowed us to model the significant excess in photoelectric absorption with respect to the Galactic value as due to a large column density (about 6.5E+22 cm^-2) in the GRB host, located at z=4.2. Such a picture is also consistent with the infrared transient's properties. Re-analysis of the prompt emission, based on INTEGRAL and on Swift data, excludes any significant modulation at P=8.1 s. Thus, we conclude that GRB 090709A is a distant, standard, long GRB., Comment: 7 pages, 7 figures, 2 tables; MNRAS, in press. (V3: minor changes to match the final version.)

The radio-quiet neutron star 1E1207.4-5209 has been the target of several XMM-Newton observations, with a total exposure of ~350 ks. The source is located at intermediate galactic latitude (b~10 degrees), i.e. in a sky region with an extremely interesting mix of both galactic and extra-galactic X-ray sources. The aim of our work is to investigate the properties of both the intermediate-latitude galactic and extra-galactic X-ray source populations in the 1E1207.4-5209 field. We performed a coherent analysis of the whole XMM-Newton observation data set to build a catalogue of serendipitous X-ray sources detected with high confidence and to derive information on the source flux, spectra, and time variability. In addition, we performed a complete multi-band (UBVRI) optical coverage of the field with the Wide Field Imager (WFI) of the ESO/MPG 2.2m telescope (La Silla) to search for candidate optical counterparts to the X-ray sources, down to a V-band limiting magnitude of ~24.5. We detected a total of 144 serendipitous X-ray sources. Thanks to the refined X-ray positions and to the WFI observations, we found candidate optical counterparts for most of the X-ray sources in our compilation. For most of the brightest ones we proposed a likely classification based on both the X-ray spectra and the optical colours. Our results indicate that at intermediate galactic latitude the X-ray source population is dominated by the extra-galactic component, but with a significant contribution from the galactic component in the soft energy band, below 2 keV., Comment: 19 pages, 16 figures, 5 tables. Accepted for publication by Astronomy & Astrophysics

GRB 090709A is a long gamma-ray burst (GRB) discovered by Swift, featuring a bright X-ray afterglow as well as a faint infrared transient with very red and peculiar colors. The burst attracted a large interest because of a possible quasi-periodicity at P=8.1 s in the prompt emission, suggesting that it could have a different origin with respect to standard, long GRBs. In order to understand the nature of this burst, we obtained a target of opportunity observation with XMM-Newton. X-ray spectroscopy, based on XMM-Newton and Swift data, allowed us to model the significant excess in photoelectric absorption with respect to the Galactic value as due to a large column density (about 6.5E+22 cm^-2) in the GRB host, located at z=4.2. Such a picture is also consistent with the infrared transient's properties. Re-analysis of the prompt emission, based on INTEGRAL and on Swift data, excludes any significant modulation at P=8.1 s. Thus, we conclude that GRB 090709A is a distant, standard, long GRB., Comment: 7 pages, 7 figures, 2 tables; MNRAS, in press. (V3: minor changes to match the final version.)