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This paper presents a methodology for enhancing relation extraction from biomedical texts, focusing specifically on chemical-gene interactions. Leveraging the BioBERT model and a multi-layer fully connected network architecture, our approach integrates the ChemProt and DrugProt datasets using a novel merging strategy. Through extensive experimentation, we demonstrate significant performance improvements, particularly in CPR groups shared between the datasets. The findings underscore the importance of dataset merging in augmenting sample counts and improving model accuracy. Moreover, the study highlights the potential of automated information extraction in biomedical research and clinical practice.

In recent years, the increasing threat of devastating wildfires has underscored the need for effective prescribed fire management. Process-based computer simulations have traditionally been employed to plan prescribed fires for wildfire prevention. However, even simplified process models like QUIC-Fire are too compute-intensive to be used for real-time decision-making, especially when weather conditions change rapidly. Traditional ML methods used for fire modeling offer computational speedup but struggle with physically inconsistent predictions, biased predictions due to class imbalance, biased estimates for fire spread metrics (e.g., burned area, rate of spread), and generalizability in out-of-distribution wind conditions. This paper introduces a novel machine learning (ML) framework that enables rapid emulation of prescribed fires while addressing these concerns. By incorporating domain knowledge, the proposed method helps reduce physical inconsistencies in fuel density estimates in data-scarce scenarios. To overcome the majority class bias in predictions, we leverage pre-existing source domain data to augment training data and learn the spread of fire more effectively. Finally, we overcome the problem of biased estimation of fire spread metrics by incorporating a hierarchical modeling structure to capture the interdependence in fuel density and burned area. Notably, improvement in fire metric (e.g., burned area) estimates offered by our framework makes it useful for fire managers, who often rely on these fire metric estimates to make decisions about prescribed burn management. Furthermore, our framework exhibits better generalization capabilities than the other ML-based fire modeling methods across diverse wind conditions and ignition patterns.

Research has shown that climate change creates warmer temperatures and drier conditions, leading to longer wildfire seasons and increased wildfire risks in the United States. These factors have in turn led to increases in the frequency, extent, and severity of wildfires in recent years. Given the danger posed by wildland fires to people, property, wildlife, and the environment, there is an urgency to provide tools for effective wildfire management. Early detection of wildfires is essential to minimizing potentially catastrophic destruction. In this paper, we present our work on integrating multiple data sources in SmokeyNet, a deep learning model using spatio-temporal information to detect smoke from wildland fires. Camera image data is integrated with weather sensor measurements and processed by SmokeyNet to create a multimodal wildland fire smoke detection system. We present our results comparing performance in terms of both accuracy and time-to-detection for multimodal data vs. a single data source. With a time-to-detection of only a few minutes, SmokeyNet can serve as an automated early notification system, providing a useful tool in the fight against destructive wildfires.

The size and frequency of wildland fires in the western United States have dramatically increased in recent years. On high-fire-risk days, a small fire ignition can rapidly grow and become out of control. Early detection of fire ignitions from initial smoke can assist the response to such fires before they become difficult to manage. Past deep learning approaches for wildfire smoke detection have suffered from small or unreliable datasets that make it difficult to extrapolate performance to real-world scenarios. In this work, we present the Fire Ignition Library (FIgLib), a publicly available dataset of nearly 25,000 labeled wildfire smoke images as seen from fixed-view cameras deployed in Southern California. We also introduce SmokeyNet, a novel deep learning architecture using spatiotemporal information from camera imagery for real-time wildfire smoke detection. When trained on the FIgLib dataset, SmokeyNet outperforms comparable baselines and rivals human performance. We hope that the availability of the FIgLib dataset and the SmokeyNet architecture will inspire further research into deep learning methods for wildfire smoke detection, leading to automated notification systems that reduce the time to wildfire response.

The goal of this project is to use magnetic resonance imaging (MRI) data to provide an end-to-end analytics pipeline for left and right ventricle (LV and RV) segmentation. Another aim of the project is to find a model that would be generalizable across medical imaging datasets. We utilized a variety of models, datasets, and tests to determine which one is well suited to this purpose. Specifically, we implemented three models (2-D U-Net, 3-D U-Net, and DenseNet), and evaluated them on four datasets (Automated Cardiac Diagnosis Challenge, MICCAI 2009 LV, Sunnybrook Cardiac Data, MICCAI 2012 RV). While maintaining a consistent preprocessing strategy, we tested the performance of each model when trained on data from the same dataset as the test data, and when trained on data from a different dataset than the test dataset. Data augmentation was also used to increase the adaptability of the models. The results were compared to determine performance and generalizability.

Reproducibility of computational studies is a hallmark of scientific methodology. It enables researchers to build with confidence on the methods and findings of others, reuse and extend computational pipelines, and thereby drive scientific progress. Since many experimental studies rely on computational analyses, biologists need guidance on how to set up and document reproducible data analyses or simulations. In this paper, we address several questions about reproducibility. For example, what are the technical and non-technical barriers to reproducible computational studies? What opportunities and challenges do computational notebooks offer to overcome some of these barriers? What tools are available and how can they be used effectively? We have developed a set of rules to serve as a guide to scientists with a specific focus on computational notebook systems, such as Jupyter Notebooks, which have become a tool of choice for many applications. Notebooks combine detailed workflows with narrative text and visualization of results. Combined with software repositories and open source licensing, notebooks are powerful tools for transparent, collaborative, reproducible, and reusable data analyses.

Reproducibility of computational studies is a hallmark of scientific methodology. It enables researchers to build with confidence on the methods and findings of others, reuse and extend computational pipelines, and thereby drive scientific progress. Since many experimental studies rely on computational analyses, biologists need guidance on how to set up and document reproducible data analyses or simulations. In this paper, we address several questions about reproducibility. For example, what are the technical and non-technical barriers to reproducible computational studies? What opportunities and challenges do computational notebooks offer to overcome some of these barriers? What tools are available and how can they be used effectively? We have developed a set of rules to serve as a guide to scientists with a specific focus on computational notebook systems, such as Jupyter Notebooks, which have become a tool of choice for many applications. Notebooks combine detailed workflows with narrative text and visualization of results. Combined with software repositories and open source licensing, notebooks are powerful tools for transparent, collaborative, reproducible, and reusable data analyses.

In the United States, heart disease is the leading cause of death for both men and women, accounting for 610,000 deaths each year [1]. Physicians use Magnetic Resonance Imaging (MRI) scans to take images of the heart in order to non-invasively estimate its structural and functional parameters for cardiovascular diagnosis and disease management. The end-systolic volume (ESV) and end-diastolic volume (EDV) of the left ventricle (LV), and the ejection fraction (EF) are indicators of heart disease. These measures can be derived from the segmented contours of the LV; thus, consistent and accurate segmentation of the LV from MRI images are critical to the accuracy of the ESV, EDV, and EF, and to non-invasive cardiac disease detection. In this work, various image preprocessing techniques, model configurations using the U-Net deep learning architecture, postprocessing methods, and approaches for volume estimation are investigated. An end-to-end analytics pipeline with multiple stages is provided for automated LV segmentation and volume estimation. First, image data are reformatted and processed from DICOM and NIfTI formats to raw images in array format. Secondly, raw images are processed with multiple image preprocessing methods and cropped to include only the Region of Interest (ROI). Thirdly, preprocessed images are segmented using U-Net models. Lastly, post processing of segmented images to remove extra contours along with intelligent slice and frame selection are applied, followed by calculation of the ESV, EDV, and EF. This analytics pipeline is implemented and runs on a distributed computing environment with a GPU cluster at the San Diego Supercomputer Center at UCSD., Comment: 42 pages

The identification of novel endothelial-derived genes is important in the study of angiogenesis, and may have potential uses in cancer diagnosis and treatment. We performed SSH (suppression subtractive hybridization) on control HUVECs (human umbilical vein endothelial cells) versus HUVECs exposed to tumor-conditioned media. We found that a novel cDNA (Genbank accession # AF358829) is differentially expressed in endothelial cells on Northern analysis, and named it Endothelial-derived gene-1 (EG-1). This gene product is predicted to encode a 178-aa, 19.5 kD protein, and is localized to chromosome #4. It has some homology to a mouse cDNA (94%) and a Drosophila cDNA (31%). On Northern analysis, endothelial cells express two EG-1 RNA species (1.2 kb and 2.4 kb). The expression of either transcripts is upregulated by endothelial cells when exposed to tumor conditioned media. This phenomenon is observed only in sparse conditions (50% confluency). Transcripts are present abundantly in highly vascular tissues such as placenta, testis, and liver. Interestingly, both Northern analysis and in situ hybridization studies show that this gene is expressed in other cell types as well, predominantly the epithelial type. Breast cancer, prostate cancer, and colon cancer cells show elevated expression of the higher 2.4 kb RNA form. Our data suggest that EG-1 is associated with a stimulated state in endothelial and epithelial cells, and may have a role in tumor angiogenesis., The original document contains color images. All DTIC reproductions will be in black and white.