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Hematopoietic stem cell transplantation (HSCT) is often the only curative treatment option for patients suffering from various types of malignant diseases and some non-cancerous conditions. Nevertheless, it is associated with a high risk of complications leading to transplant-related mortality and long-term morbidity. An increasing number of therapeutic and prevention strategies have been developed over the last few years to tackle the complications arising in patients receiving an HSCT. These strategies have been mainly carried out in adults and some are now being translated into children. In this manuscript, we review the recent advancements in the development and implementation of treatment options for post-HSCT non-infectious complications in pediatric patients with leukemia and other non-malignant conditions, with a special attention on the new agents available within clinical trials. We focused on the following conditions: graft failure, prevention of relapse and early interventions after detection of minimal residual disease positivity following HSCT in acute lymphoblastic and myeloid leukemia, chronic graft versus host disease, non-infectious pulmonary complications, and complications of endothelial origin.

We have a limited arsenal with which to treat invasive fungal infections caused by Aspergillus and Mucorales. The morbidity and mortality for both pathogens remains high. A triazole antifungal, isavuconazole, was recently granted approval by the US Food and Drug Administration and the European Medicines Agency for the treatment of invasive aspergillosis and mucormycosis. A randomized double-blind comparison trial for the treatment of invasive aspergillosis found isavuconazole noninferior to voriconazole. A separate, open-label study evaluating the efficacy of isavuconazole in the treatment of mucormycosis found comparable response rates to amphotericin B and posaconazole treated historical controls. The prodrug isavuconazonium sulfate is commercially available in both an oral and intravenous formulation and is generally well tolerated. Isavuconazole's broad spectrum of activity, limited side effect profile, and favorable pharmacokinetics will likely solidify its place in therapy.

We have a limited arsenal with which to treat invasive fungal infections caused by Aspergillus and Mucorales. The morbidity and mortality for both pathogens remains high. A triazole antifungal, isavuconazole, was recently granted approval by the US Food and Drug Administration and the European Medicines Agency for the treatment of invasive aspergillosis and mucormycosis. A randomized double-blind comparison trial for the treatment of invasive aspergillosis found isavuconazole noninferior to voriconazole. A separate, open-label study evaluating the efficacy of isavuconazole in the treatment of mucormycosis found comparable response rates to amphotericin B and posaconazole treated historical controls. The prodrug isavuconazonium sulfate is commercially available in both an oral and intravenous formulation and is generally well tolerated. Isavuconazole's broad spectrum of activity, limited side effect profile, and favorable pharmacokinetics will likely solidify its place in therapy.

Introduction: First and second generation tyrosine kinase inhibitors, represent a new, fully biologic and targeted approach to chronic lymphocytic leukemia and allowed to obtain high responses and acceptable tolerability even in elderly and high risk patients. On the other hand, prolonged experience with these agents has raised some questions on unexpected toxicities, response quality, treatment duration and onset of resistances. Areas covered: This review analyzes the main published studies with the aim to discuss whether, in future, new agents could become a part of standard treatments or even replace the chemo-immunotherapy in chronic lymphocytic leukemia. Expert commentary: Despite different trials has been already published and many are still ongoing, follow up times are, at present, too short. A chemo-free approach surely represents a desirable goal for chronic lymphocytic leukemia, nevertheless longer observation is warranted to better define the correct use of targeted therapies.

Actualmente en el sector vitivinícola español conviven numerosas marcas, pero se produce el fenómeno de carencia de marcas sólidas. Además, hay muchas empresas con un volumen de producción pequeño que no disponen de recursos financieros para realizar políticas de marca; por todo esto podemos decir que el sector vitivinícola es maduro y muy competitivo. El objetivo de presente estudio es determinar los factores que influyen en elección de la marca de distribuidor frente a la de fabricante a la hora de comercializar los diferentes tipos de vino, así como determinar las posibles implicaciones en la gestión de los bodegueros provocadas por la aparición de marcas de distribuidor. Las conclusiones a las que hemos llegado ponen de manifiesto que en el sector vitivinícola los distribuidores tienen más poder de mercado que los productores, lo que les permite comercializar el vino bajo su propia marca, así como posicionarse en el mercado con precios más bajos., Currently, a lot of brands coexist in the Spanish wine sector, but there aren´t strong brands. Furthermore, there are many companies with a small production volume which haven´t financial resources to carry out brand management; so, this is the reason to say that the wine sector is mature and it is very competitive. The objective of this paper is to know the main factors which affect the distributor brand choice when we comercialize different wines, as well as, to know the possible implications in the wine producers management due to the appearance of distributor brands. The main conclusions are that the distributors have the higher market-power in the wine sector, which allows them to commercialize the wine with their own brand, as well as to be positioned in the market with lower prices.

Actualmente en el sector vitivinícola español conviven numerosas marcas, pero se produce el fenómeno de carencia de marcas sólidas. Además, hay muchas empresas con un volumen de producción pequeño que no disponen de recursos financieros para realizar políticas de marca; por todo esto podemos decir que el sector vitivinícola es maduro y muy competitivo. El objetivo de presente estudio es determinar los factores que influyen en elección de la marca de distribuidor frente a la de fabricante a la hora de comercializar los diferentes tipos de vino, así como determinar las posibles implicaciones en la gestión de los bodegueros provocadas por la aparición de marcas de distribuidor. Las conclusiones a las que hemos llegado ponen de manifiesto que en el sector vitivinícola los distribuidores tienen más poder de mercado que los productores, lo que les permite comercializar el vino bajo su propia marca, así como posicionarse en el mercado con precios más bajos., Currently, a lot of brands coexist in the Spanish wine sector, but there aren´t strong brands. Furthermore, there are many companies with a small production volume which haven´t financial resources to carry out brand management; so, this is the reason to say that the wine sector is mature and it is very competitive. The objective of this paper is to know the main factors which affect the distributor brand choice when we comercialize different wines, as well as, to know the possible implications in the wine producers management due to the appearance of distributor brands. The main conclusions are that the distributors have the higher market-power in the wine sector, which allows them to commercialize the wine with their own brand, as well as to be positioned in the market with lower prices.

Actualmente en el sector vitivinícola español conviven numerosas marcas, pero se produce el fenómeno de carencia de marcas sólidas. Además, hay muchas empresas con un volumen de producción pequeño que no disponen de recursos financieros para realizar políticas de marca; por todo esto podemos decir que el sector vitivinícola es maduro y muy competitivo. El objetivo de presente estudio es determinar los factores que influyen en elección de la marca de distribuidor frente a la de fabricante a la hora de comercializar los diferentes tipos de vino, así como determinar las posibles implicaciones en la gestión de los bodegueros provocadas por la aparición de marcas de distribuidor. Las conclusiones a las que hemos llegado ponen de manifiesto que en el sector vitivinícola los distribuidores tienen más poder de mercado que los productores, lo que les permite comercializar el vino bajo su propia marca, así como posicionarse en el mercado con precios más bajos., Currently, a lot of brands coexist in the Spanish wine sector, but there aren´t strong brands. Furthermore, there are many companies with a small production volume which haven´t financial resources to carry out brand management; so, this is the reason to say that the wine sector is mature and it is very competitive. The objective of this paper is to know the main factors which affect the distributor brand choice when we comercialize different wines, as well as, to know the possible implications in the wine producers management due to the appearance of distributor brands. The main conclusions are that the distributors have the higher market-power in the wine sector, which allows them to commercialize the wine with their own brand, as well as to be positioned in the market with lower prices.

Actualmente en el sector vitivinícola español conviven numerosas marcas, pero se produce el fenómeno de carencia de marcas sólidas. Además, hay muchas empresas con un volumen de producción pequeño que no disponen de recursos financieros para realizar políticas de marca; por todo esto podemos decir que el sector vitivinícola es maduro y muy competitivo. El objetivo de presente estudio es determinar los factores que influyen en elección de la marca de distribuidor frente a la de fabricante a la hora de comercializar los diferentes tipos de vino, así como determinar las posibles implicaciones en la gestión de los bodegueros provocadas por la aparición de marcas de distribuidor. Las conclusiones a las que hemos llegado ponen de manifiesto que en el sector vitivinícola los distribuidores tienen más poder de mercado que los productores, lo que les permite comercializar el vino bajo su propia marca, así como posicionarse en el mercado con precios más bajos., Currently, a lot of brands coexist in the Spanish wine sector, but there aren´t strong brands. Furthermore, there are many companies with a small production volume which haven´t financial resources to carry out brand management; so, this is the reason to say that the wine sector is mature and it is very competitive. The objective of this paper is to know the main factors which affect the distributor brand choice when we comercialize different wines, as well as, to know the possible implications in the wine producers management due to the appearance of distributor brands. The main conclusions are that the distributors have the higher market-power in the wine sector, which allows them to commercialize the wine with their own brand, as well as to be positioned in the market with lower prices.

Actualmente en el sector vitivinícola español conviven numerosas marcas, pero se produce el fenómeno de carencia de marcas sólidas. Además, hay muchas empresas con un volumen de producción pequeño que no disponen de recursos financieros para realizar políticas de marca; por todo esto podemos decir que el sector vitivinícola es maduro y muy competitivo. El objetivo de presente estudio es determinar los factores que influyen en elección de la marca de distribuidor frente a la de fabricante a la hora de comercializar los diferentes tipos de vino, así como determinar las posibles implicaciones en la gestión de los bodegueros provocadas por la aparición de marcas de distribuidor. Las conclusiones a las que hemos llegado ponen de manifiesto que en el sector vitivinícola los distribuidores tienen más poder de mercado que los productores, lo que les permite comercializar el vino bajo su propia marca, así como posicionarse en el mercado con precios más bajos., Currently, a lot of brands coexist in the Spanish wine sector, but there aren´t strong brands. Furthermore, there are many companies with a small production volume which haven´t financial resources to carry out brand management; so, this is the reason to say that the wine sector is mature and it is very competitive. The objective of this paper is to know the main factors which affect the distributor brand choice when we comercialize different wines, as well as, to know the possible implications in the wine producers management due to the appearance of distributor brands. The main conclusions are that the distributors have the higher market-power in the wine sector, which allows them to commercialize the wine with their own brand, as well as to be positioned in the market with lower prices.