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Negative ions are unique quantum systems where electron correlation plays a decisive role in determining their properties. The lack of optically allowed transitions prevents traditional optical spectroscopy and the electron affinity is, therefore, for most elements, the only atomic quantity that can be determined with high accuracy. In this work, we present a high-precision experimental determination of the electron affinity of cesium. A collinear laser-ion beam apparatus was used to investigate the partial photodetachment cross section for the cesium anion, leaving the neutral atom in the 6p2P3/2 excited state. A resonance ionization scheme was used to obtain final-state selectivity, which enabled the investigation of a sharp onset of the cross section associated with a Wigner s-wave threshold behavior. The electron affinity was determined to be 0.471 598 3(38) eV.

Negative ions are unique quantum systems where electron correlation plays a decisive role in determining their properties. The lack of optically allowed transitions prevents traditional optical spectroscopy and the electron affinity is, therefore, for most elements, the only atomic quantity that can be determined with high accuracy. In this work, we present a high-precision experimental determination of the electron affinity of cesium. A collinear laser-ion beam apparatus was used to investigate the partial photodetachment cross section for the cesium anion, leaving the neutral atom in the 6p2P3/2 excited state. A resonance ionization scheme was used to obtain final-state selectivity, which enabled the investigation of a sharp onset of the cross section associated with a Wigner s-wave threshold behavior. The electron affinity was determined to be 0.471 598 3(38) eV.

Negative ions are unique quantum systems where electron correlation plays a decisive role in determining their properties. The lack of optically allowed transitions prevents traditional optical spectroscopy and the electron affinity is, therefore, for most elements, the only atomic quantity that can be determined with high accuracy. In this work, we present a high-precision experimental determination of the electron affinity of cesium. A collinear laser-ion beam apparatus was used to investigate the partial photodetachment cross section for the cesium anion, leaving the neutral atom in the 6p2P3/2 excited state. A resonance ionization scheme was used to obtain final-state selectivity, which enabled the investigation of a sharp onset of the cross section associated with a Wigner s-wave threshold behavior. The electron affinity was determined to be 0.471 598 3(38) eV.

In this work we have performed Laser Photodetachment Threshold Spectroscopy (LPTS) to determine the electron affinities of the atomic species $^{133}$Cs and $^{16}$O with high precision. The negative ion of Cesium has been produced and investigated at the Gothenburg University Negative Ion and Laser LAboratory (GUNILLA) while the Oxygen anion have been studied in the Double ElectroStatic Ion Ring ExpEriment (DESIREE) at Stockholm University. Pilot studies have also been carried out to measure the electron affinity of complex molecular systems in DESIREE. Specifically, we have studied the beautifully symmetric fullerene C$_{60}^-$ negative ion and its spontaneous and laser induced decays. A preliminary analysis suggests that DESIREE's internal temperature of $\unit{13}{\kelvin}$ may allow an efficient cooling of these initially created hot molecules on time scales of a few seconds. This is a key aspect in measuring detachment thresholds as cooling suppresses hot band contributions associated with vibrationally excited states. Therefore, photodetachment techniques of the types successfully used for atomic species can be implemented for molecules. The preliminary results appear to settle a matter of disagreement in the literature concerning the most precise method to measure the EA of C$_{60}$, that is, LPTS or Photodetachment Electron Spectroscopy (PES).

In this work we have performed Laser Photodetachment Threshold Spectroscopy (LPTS) to determine the electron affinities of the atomic species $^{133}$Cs and $^{16}$O with high precision. The negative ion of Cesium has been produced and investigated at the Gothenburg University Negative Ion and Laser LAboratory (GUNILLA) while the Oxygen anion have been studied in the Double ElectroStatic Ion Ring ExpEriment (DESIREE) at Stockholm University. Pilot studies have also been carried out to measure the electron affinity of complex molecular systems in DESIREE. Specifically, we have studied the beautifully symmetric fullerene C$_{60}^-$ negative ion and its spontaneous and laser induced decays. A preliminary analysis suggests that DESIREE's internal temperature of $\unit{13}{\kelvin}$ may allow an efficient cooling of these initially created hot molecules on time scales of a few seconds. This is a key aspect in measuring detachment thresholds as cooling suppresses hot band contributions associated with vibrationally excited states. Therefore, photodetachment techniques of the types successfully used for atomic species can be implemented for molecules. The preliminary results appear to settle a matter of disagreement in the literature concerning the most precise method to measure the EA of C$_{60}$, that is, LPTS or Photodetachment Electron Spectroscopy (PES).

In this work we have performed Laser Photodetachment Threshold Spectroscopy (LPTS) to determine the electron affinities of the atomic species $^{133}$Cs and $^{16}$O with high precision. The negative ion of Cesium has been produced and investigated at the Gothenburg University Negative Ion and Laser LAboratory (GUNILLA) while the Oxygen anion have been studied in the Double ElectroStatic Ion Ring ExpEriment (DESIREE) at Stockholm University. Pilot studies have also been carried out to measure the electron affinity of complex molecular systems in DESIREE. Specifically, we have studied the beautifully symmetric fullerene C$_{60}^-$ negative ion and its spontaneous and laser induced decays. A preliminary analysis suggests that DESIREE's internal temperature of $\unit{13}{\kelvin}$ may allow an efficient cooling of these initially created hot molecules on time scales of a few seconds. This is a key aspect in measuring detachment thresholds as cooling suppresses hot band contributions associated with vibrationally excited states. Therefore, photodetachment techniques of the types successfully used for atomic species can be implemented for molecules. The preliminary results appear to settle a matter of disagreement in the literature concerning the most precise method to measure the EA of C$_{60}$, that is, LPTS or Photodetachment Electron Spectroscopy (PES).

In this work we have performed Laser Photodetachment Threshold Spectroscopy (LPTS) to determine the electron affinities of the atomic species $^{133}$Cs and $^{16}$O with high precision. The negative ion of Cesium has been produced and investigated at the Gothenburg University Negative Ion and Laser LAboratory (GUNILLA) while the Oxygen anion have been studied in the Double ElectroStatic Ion Ring ExpEriment (DESIREE) at Stockholm University. Pilot studies have also been carried out to measure the electron affinity of complex molecular systems in DESIREE. Specifically, we have studied the beautifully symmetric fullerene C$_{60}^-$ negative ion and its spontaneous and laser induced decays. A preliminary analysis suggests that DESIREE's internal temperature of $\unit{13}{\kelvin}$ may allow an efficient cooling of these initially created hot molecules on time scales of a few seconds. This is a key aspect in measuring detachment thresholds as cooling suppresses hot band contributions associated with vibrationally excited states. Therefore, photodetachment techniques of the types successfully used for atomic species can be implemented for molecules. The preliminary results appear to settle a matter of disagreement in the literature concerning the most precise method to measure the EA of C$_{60}$, that is, LPTS or Photodetachment Electron Spectroscopy (PES).

Negative ions are important in many areas of science and technology, e.g., in interstellar chemistry, for accelerator-based radionuclide dating, and in anti-matter research. They are unique quantum systems where electron-correlation effects govern their properties. Atomic anions are loosely bound systems, which with very few exceptions lack optically allowed transitions. This limits prospects for high-resolution spectroscopy, and related negative-ion detection methods. Here, we present a method to measure negative ion binding energies with an order of magnitude higher precision than what has been possible before. By laser-manipulation of quantum-state populations, we are able to strongly reduce the background from photodetachment of excited states using a cryogenic electrostatic ion-beam storage ring where keV ion beams can circulate for up to hours. The method is applicable to negative ions in general and here we report an electron affinity of 1.461 112 972(87) eV for O-16. High-precision measurements are useful to find isotopic shifts and electron correlation. Here the authors measure electron affinity and hyperfine splitting of atomic oxygen with higher precision than previous studies.

Negative ions are important in many areas of science and technology, e.g., in interstellar chemistry, for accelerator-based radionuclide dating, and in anti-matter research. They are unique quantum systems where electron-correlation effects govern their properties. Atomic anions are loosely bound systems, which with very few exceptions lack optically allowed transitions. This limits prospects for high-resolution spectroscopy, and related negative-ion detection methods. Here, we present a method to measure negative ion binding energies with an order of magnitude higher precision than what has been possible before. By laser-manipulation of quantum-state populations, we are able to strongly reduce the background from photodetachment of excited states using a cryogenic electrostatic ion-beam storage ring where keV ion beams can circulate for up to hours. The method is applicable to negative ions in general and here we report an electron affinity of 1.461 112 972(87) eV for O-16. High-precision measurements are useful to find isotopic shifts and electron correlation. Here the authors measure electron affinity and hyperfine splitting of atomic oxygen with higher precision than previous studies.

Negative ions are important in many areas of science and technology, e.g., in interstellar chemistry, for accelerator-based radionuclide dating, and in anti-matter research. They are unique quantum systems where electron-correlation effects govern their properties. Atomic anions are loosely bound systems, which with very few exceptions lack optically allowed transitions. This limits prospects for high-resolution spectroscopy, and related negative-ion detection methods. Here, we present a method to measure negative ion binding energies with an order of magnitude higher precision than what has been possible before. By laser-manipulation of quantum-state populations, we are able to strongly reduce the background from photodetachment of excited states using a cryogenic electrostatic ion-beam storage ring where keV ion beams can circulate for up to hours. The method is applicable to negative ions in general and here we report an electron affinity of 1.461 112 972(87) eV for O-16. High-precision measurements are useful to find isotopic shifts and electron correlation. Here the authors measure electron affinity and hyperfine splitting of atomic oxygen with higher precision than previous studies.

Negative ions are important in many areas of science and technology, e.g., in interstellar chemistry, for accelerator-based radionuclide dating, and in anti-matter research. They are unique quantum systems where electron-correlation effects govern their properties. Atomic anions are loosely bound systems, which with very few exceptions lack optically allowed transitions. This limits prospects for high-resolution spectroscopy, and related negative-ion detection methods. Here, we present a method to measure negative ion binding energies with an order of magnitude higher precision than what has been possible before. By laser-manipulation of quantum-state populations, we are able to strongly reduce the background from photodetachment of excited states using a cryogenic electrostatic ion-beam storage ring where keV ion beams can circulate for up to hours. The method is applicable to negative ions in general and here we report an electron affinity of 1.461 112 972(87) eV for O-16. High-precision measurements are useful to find isotopic shifts and electron correlation. Here the authors measure electron affinity and hyperfine splitting of atomic oxygen with higher precision than previous studies.

Negative ions are important in many areas of science and technology, e.g., in interstellar chemistry, for accelerator-based radionuclide dating, and in anti-matter research. They are unique quantum systems where electron-correlation effects govern their properties. Atomic anions are loosely bound systems, which with very few exceptions lack optically allowed transitions. This limits prospects for high-resolution spectroscopy, and related negative-ion detection methods. Here, we present a method to measure negative ion binding energies with an order of magnitude higher precision than what has been possible before. By laser-manipulation of quantum-state populations, we are able to strongly reduce the background from photodetachment of excited states using a cryogenic electrostatic ion-beam storage ring where keV ion beams can circulate for up to hours. The method is applicable to negative ions in general and here we report an electron affinity of 1.461 112 972(87) eV for O-16. High-precision measurements are useful to find isotopic shifts and electron correlation. Here the authors measure electron affinity and hyperfine splitting of atomic oxygen with higher precision than previous studies.

BACKGROUND: Emory Dialysis serves an urban and predominantly African American population at its four outpatient dialysis facilities. We describe COVID-19 infection control measures implemented and clinical characteristics of patients with COVID-19 in the Emory Dialysis facilities. METHODS: Implementation of COVID-19 infection procedures commenced in February 2020. Subsequently, COVID-19 preparedness assessments were conducted at each facility. Patients with COVID-19 from March 1-May 31, 2020 were included; with a follow-up period spanning March-June 30, 2020. Percentages of patients diagnosed with COVID-19 were calculated, and characteristics of COVID-19 patients were summarized as medians or percentage. Baseline characteristics of all patients receiving care at Emory Dialysis (i.e. Emory general dialysis population) were presented as medians and percentages. RESULTS: Of 751 dialysis patients, 23 (3.1%) were diagnosed with COVID-19. The median age was 67.0 years and 13 patients (56.6%) were female. Eleven patients (47.8%) were residents of nursing homes. Nineteen patients (82.6%) required hospitalization and 6 patients (26.1%) died; the average number of days from a positive SARS-CoV-2 (COVID) test to death was 16.8 days (range 1-34). Two patients dialyzing at adjacent dialysis stations and a dialysis staff who cared for them, were diagnosed with COVID-19 in a time frame that may suggest transmission in the dialysis facility. In response, universal masking in the facility was implemented (prior to national guidelines recommending universal masking), infection control audits and re-trainings of PPE were also done to bolster infection control practices. CONCLUSION: We successfully implemented recommended COVID-19 infection control measures aimed at mitigating the spread of SARS-CoV-2. Most of the patients with COVID-19 required hospitalizations. Dialysis facilities should remain vigilant and monitor for possible transmission of COVID-19 in the facility.

When illuminated with visible light, nanostructured noble metals exhibit a strongplasmon resonance at wavelength, p, that has been shown to be sensitive to its size,structure, the dielectric properties of the surrounding medium, and charge density. Thetunability of the plasmon resonance has allowed metal nanosystems to be fabricated withresonances matching the solar spectrum for us in plasmon promoted catalysis, plasmonicphotovoltaics, and surface-enhanced raman spectroscopy. Here we use UV-Visible spectroscopyto track the shifts of the plasmon resonances from an array of gold nanoparticlesburied under metal oxide layers of varying thickness when in contact with one of two bulkmetals: aluminum or silver. By assuming the array of gold nanoparticles and metal-oxidelayers to be an optically homogenous lm of core-shell particles on a substrate, we developeda Maxwell-Garnett effective medium approximation to extract reliable opticalparameters for the gold nanoparticles, yielding their charge state before and after contactwith the bulk metal.Based on the optical parameters extracted from our model, we nd the magnitude ofcharge transfer from the bulk metal to the gold nanoparticle is independent of the workfunction of the bulk metal. Furthermore, when gold is used as the bulk layer in contactwith the gold nanoparticles, we measured an appreciable amount of charge transfer to thegold nanoparticles, failing to support the well-established model for electrostatic contactelectrication. Instead, we attribute the charge transfer to the so called plasmoelectriceffect, an optically induced charge transfer mechanism, in which the gold nanoparticlemodifes its charge density to allow its resonant wavelength to match that of the incidentlight. We show, however, that in our devices the Schottky barriers between the metalsand the metal oxide layers create a rectication effect that favors electron transfer fromthe bulk metal to the nanoparticles over the reverse effect.

When illuminated with visible light, nanostructured noble metals exhibit a strongplasmon resonance at wavelength, p, that has been shown to be sensitive to its size,structure, the dielectric properties of the surrounding medium, and charge density. Thetunability of the plasmon resonance has allowed metal nanosystems to be fabricated withresonances matching the solar spectrum for us in plasmon promoted catalysis, plasmonicphotovoltaics, and surface-enhanced raman spectroscopy. Here we use UV-Visible spectroscopyto track the shifts of the plasmon resonances from an array of gold nanoparticlesburied under metal oxide layers of varying thickness when in contact with one of two bulkmetals: aluminum or silver. By assuming the array of gold nanoparticles and metal-oxidelayers to be an optically homogenous lm of core-shell particles on a substrate, we developeda Maxwell-Garnett effective medium approximation to extract reliable opticalparameters for the gold nanoparticles, yielding their charge state before and after contactwith the bulk metal.Based on the optical parameters extracted from our model, we nd the magnitude ofcharge transfer from the bulk metal to the gold nanoparticle is independent of the workfunction of the bulk metal. Furthermore, when gold is used as the bulk layer in contactwith the gold nanoparticles, we measured an appreciable amount of charge transfer to thegold nanoparticles, failing to support the well-established model for electrostatic contactelectrication. Instead, we attribute the charge transfer to the so called plasmoelectriceffect, an optically induced charge transfer mechanism, in which the gold nanoparticlemodifes its charge density to allow its resonant wavelength to match that of the incidentlight. We show, however, that in our devices the Schottky barriers between the metalsand the metal oxide layers create a rectication effect that favors electron transfer fromthe bulk metal to the nanoparticles over the reverse effect.

A growing demand for global information has weakened financial statements importance as sources of information for the outside world. In their stead, the market demands for information on social and environmental issues. In this scenario, the Integrated Reporting appears as a relevant actor, given that, in a single document, it encompasses financial and non-financial information, showing a global image of the reporting company, with an emphasis on strategic, governance and creation of value. There is enough evidence to consider integrated reporting as a key component of corporate reporting. So, the academy is called upon to investigate this phenomenon along with promoting good business practices. There is no doubt that we are at the onset of a great revolution in terms of corporate transparency and social responsibility., La creciente demanda por información global ha hecho que la importancia de los estados financieros, como vehículos de información hacia el exterior, haya perdido fuerza. En su lugar, el mercado está solicitando información sobre diversos aspectos, tales como sociales y medioambientales. En este escenario, el Reporte Integrado aparece como un actor relevante, dado que, en un solo documento, engloba información financiera y no financiera, mostrando una imagen global de la compañía que informa, haciendo énfasis en aspectos estratégicos, de gobierno y creación de valor. La evidencia indica que este tipo de información será el futuro del reporting corporativo, por lo que la academia está llamada a investigar este fenómeno y en conjunto fomentar las buenas prácticas empresariales. Sin duda, se está frente al inicio de una gran revolución en términos de transparencia empresarial y responsabilidad social.

A growing demand for global information has weakened financial statements importance as sources of information for the outside world. In their stead, the market demands for information on social and environmental issues. In this scenario, the Integrated Reporting appears as a relevant actor, given that, in a single document, it encompasses financial and non-financial information, showing a global image of the reporting company, with an emphasis on strategic, governance and creation of value. There is enough evidence to consider integrated reporting as a key component of corporate reporting. So, the academy is called upon to investigate this phenomenon along with promoting good business practices. There is no doubt that we are at the onset of a great revolution in terms of corporate transparency and social responsibility., La creciente demanda por información global ha hecho que la importancia de los estados financieros, como vehículos de información hacia el exterior, haya perdido fuerza. En su lugar, el mercado está solicitando información sobre diversos aspectos, tales como sociales y medioambientales. En este escenario, el Reporte Integrado aparece como un actor relevante, dado que, en un solo documento, engloba información financiera y no financiera, mostrando una imagen global de la compañía que informa, haciendo énfasis en aspectos estratégicos, de gobierno y creación de valor. La evidencia indica que este tipo de información será el futuro del reporting corporativo, por lo que la academia está llamada a investigar este fenómeno y en conjunto fomentar las buenas prácticas empresariales. Sin duda, se está frente al inicio de una gran revolución en términos de transparencia empresarial y responsabilidad social.

[EN] This paper presents the design of the didactic strategy modeling language (DSML) according to the principles of Physics of Notations (PoN). The DSML is a visual and activity-oriented language for learning design characterized by the representation of different activities according to the nature of the task. Once the language is designed, a blind interpretation study is conducted to validate the semantic transparency of the learning activity iconography. The results of the paper allow to refine the icons. In addition to this, an authoring tool for DSML, which is integrated to an LMS, is presented. As a result, a model driven course was designed as a DSML pre-validation.

[EN] The Big Data domain offers valuable opportunities to gain valuable knowledge. The User Interface (UI), the place where the user interacts to extract knowledge from data, must be adapted to address the domain complexities. Designing UIs for Big Data becomes a challenge that involves identifying and designing the user-data interaction implicated in the knowledge extraction. To design such an interaction, one widely used approach is design patterns. Design Patterns describe solutions to common interaction design problems. This paper proposes a set of patterns to design UIs aimed at extracting knowledge from the Big Data systems data conceptual schemas. As a practical example, we apply the patterns to design UI s for the Diagnosis of Genetic Diseases domain since it is a clear case of extracting knowledge from a complex set of genetic data. Our patterns provide valuable design guidelines for Big Data UIs.

[EN] This paper presents the design of the didactic strategy modeling language (DSML) according to the principles of Physics of Notations (PoN). The DSML is a visual and activity-oriented language for learning design characterized by the representation of different activities according to the nature of the task. Once the language is designed, a blind interpretation study is conducted to validate the semantic transparency of the learning activity iconography. The results of the paper allow to refine the icons. In addition to this, an authoring tool for DSML, which is integrated to an LMS, is presented. As a result, a model driven course was designed as a DSML pre-validation.

[EN] The Big Data domain offers valuable opportunities to gain valuable knowledge. The User Interface (UI), the place where the user interacts to extract knowledge from data, must be adapted to address the domain complexities. Designing UIs for Big Data becomes a challenge that involves identifying and designing the user-data interaction implicated in the knowledge extraction. To design such an interaction, one widely used approach is design patterns. Design Patterns describe solutions to common interaction design problems. This paper proposes a set of patterns to design UIs aimed at extracting knowledge from the Big Data systems data conceptual schemas. As a practical example, we apply the patterns to design UI s for the Diagnosis of Genetic Diseases domain since it is a clear case of extracting knowledge from a complex set of genetic data. Our patterns provide valuable design guidelines for Big Data UIs.

[EN] Any knowledge generation process involves raw data comprehension, evaluation and inferential reasoning. These practices, common to different disciplines, are known as data analysis, and represent the most important set of activities in research contexts. Researchers use data analysis software methods and tools for generating new knowledge in their daily data analysis. In recent years, data analysis software has been incorporating explicit references in modelling of cognitive processes, in order to improve the assistance offered in data analysis tasks. However, data analysis software commercial suites are still resisting this inclusion, and there is little empirical work done in knowing more about how cognitive aspects inclusion in software helps researchers in analyzing data. In this paper, we evaluate the impact produced by the explicit inclusion of cognitive processes in the assistance logic of software tools design and development. We conducted an empirical experiment comparing data analysis performance using traditional software versus data analysis performance using software-assistance tools which incorporate cognitive processes in their design. The experiment is designed in terms of accuracy, efficiency, productivity and user satisfaction during the data analysis made by researchers. It allowed us to find some clear benefits of the cognitive inclusion in the software designed for research contexts, with statistically significant differences in terms of accuracy, productivity and researcher's satisfaction in support of this explicit inclusion, although some efficiency weaknesses are detected. We also discuss the implications of these results for the priority of cognitive inclusion in the software tools design for research contexts data analysis.

[EN] Any knowledge generation process involves raw data comprehension, evaluation and inferential reasoning. These practices, common to different disciplines, are known as data analysis, and represent the most important set of activities in research contexts. Researchers use data analysis software methods and tools for generating new knowledge in their daily data analysis. In recent years, data analysis software has been incorporating explicit references in modelling of cognitive processes, in order to improve the assistance offered in data analysis tasks. However, data analysis software commercial suites are still resisting this inclusion, and there is little empirical work done in knowing more about how cognitive aspects inclusion in software helps researchers in analyzing data. In this paper, we evaluate the impact produced by the explicit inclusion of cognitive processes in the assistance logic of software tools design and development. We conducted an empirical experiment comparing data analysis performance using traditional software versus data analysis performance using software-assistance tools which incorporate cognitive processes in their design. The experiment is designed in terms of accuracy, efficiency, productivity and user satisfaction during the data analysis made by researchers. It allowed us to find some clear benefits of the cognitive inclusion in the software designed for research contexts, with statistically significant differences in terms of accuracy, productivity and researcher's satisfaction in support of this explicit inclusion, although some efficiency weaknesses are detected. We also discuss the implications of these results for the priority of cognitive inclusion in the software tools design for research contexts data analysis.

[EN] Both the degree in Telematic Engineering and the degree in Multimedia Engineering have a subject of Software Engineering. One competence of this subject is to train students as professionals for the real world. For this aim, we have applied two versions of a role-playing game where there are both clients, who ask for a system development project, and developers. In the degree in Telematic Ingineering, the teacher plays the role of client, while students play the role of developers. Regarding the degree of Multimedia Engineering, students play both the role of client and developer at the same time (for different projects). In this paper, we tackle both experiences and we show a comparative of results. For Telematic Engineering, we ensure that the workload is the same for all the students. Moreover, the teacher can control directly the work of the students since he/she knows perfectly the project that needs to be developed. Regarding Multimedia Engineering, we try to enhance the students’ creativity since they must devise themselves a project to develop. Moreover, the students learn how to develop both roles, which can be useful for the real world., [ES] Dentro de los grados de Ingeniería Telemática e Ingeniería Multimedia se imparte la asignatura de Ingeniería del Software. Una de las competencias de esta asignatura es formar a los alumnos como profesionales para el mundo real. Para ello, hemos aplicado dos variantes de un juego de rol donde hay clientes, que solicitan un proyecto informático, y desarrolladores. En el Grado de Ingeniería Telemática (GIT), el rol de usuario final lo tomaba un único profesor, mientras que los usuarios jugaban el rol de desarrolladores. En el Grado de Ingeniería Multimedia (GIM), los estudiantes jugaban a la vez el rol de cliente y de desarrolladores (para proyectos distintos). En este artículo se abordan ambas experiencias y se presenta una comparativa de los resultados obtenidos con ellas. En el caso de GIT se garantiza que la carga de trabajo es para todos los estudiantes la misma. Además, el profesor puede llevar un seguimiento más directo al conocer de primera mano el caso a desarrollar. En el caso de GIM se potencia la creatividad de los alumnos, ya que deben inventarse el proyecto a desarrollar. Además, los alumnos aprenden a desempeñar dos roles que les pueden ser útiles en el mundo real.

[EN] Both the degree in Telematic Engineering and the degree in Multimedia Engineering have a subject of Software Engineering. One competence of this subject is to train students as professionals for the real world. For this aim, we have applied two versions of a role-playing game where there are both clients, who ask for a system development project, and developers. In the degree in Telematic Ingineering, the teacher plays the role of client, while students play the role of developers. Regarding the degree of Multimedia Engineering, students play both the role of client and developer at the same time (for different projects). In this paper, we tackle both experiences and we show a comparative of results. For Telematic Engineering, we ensure that the workload is the same for all the students. Moreover, the teacher can control directly the work of the students since he/she knows perfectly the project that needs to be developed. Regarding Multimedia Engineering, we try to enhance the students’ creativity since they must devise themselves a project to develop. Moreover, the students learn how to develop both roles, which can be useful for the real world., [ES] Dentro de los grados de Ingeniería Telemática e Ingeniería Multimedia se imparte la asignatura de Ingeniería del Software. Una de las competencias de esta asignatura es formar a los alumnos como profesionales para el mundo real. Para ello, hemos aplicado dos variantes de un juego de rol donde hay clientes, que solicitan un proyecto informático, y desarrolladores. En el Grado de Ingeniería Telemática (GIT), el rol de usuario final lo tomaba un único profesor, mientras que los usuarios jugaban el rol de desarrolladores. En el Grado de Ingeniería Multimedia (GIM), los estudiantes jugaban a la vez el rol de cliente y de desarrolladores (para proyectos distintos). En este artículo se abordan ambas experiencias y se presenta una comparativa de los resultados obtenidos con ellas. En el caso de GIT se garantiza que la carga de trabajo es para todos los estudiantes la misma. Además, el profesor puede llevar un seguimiento más directo al conocer de primera mano el caso a desarrollar. En el caso de GIM se potencia la creatividad de los alumnos, ya que deben inventarse el proyecto a desarrollar. Además, los alumnos aprenden a desempeñar dos roles que les pueden ser útiles en el mundo real.

[EN] Both the degree in Telematic Engineering and the degree in Multimedia Engineering have a subject of Software Engineering. One competence of this subject is to train students as professionals for the real world. For this aim, we have applied two versions of a role-playing game where there are both clients, who ask for a system development project, and developers. In the degree in Telematic Ingineering, the teacher plays the role of client, while students play the role of developers. Regarding the degree of Multimedia Engineering, students play both the role of client and developer at the same time (for different projects). In this paper, we tackle both experiences and we show a comparative of results. For Telematic Engineering, we ensure that the workload is the same for all the students. Moreover, the teacher can control directly the work of the students since he/she knows perfectly the project that needs to be developed. Regarding Multimedia Engineering, we try to enhance the students’ creativity since they must devise themselves a project to develop. Moreover, the students learn how to develop both roles, which can be useful for the real world., [ES] Dentro de los grados de Ingeniería Telemática e Ingeniería Multimedia se imparte la asignatura de Ingeniería del Software. Una de las competencias de esta asignatura es formar a los alumnos como profesionales para el mundo real. Para ello, hemos aplicado dos variantes de un juego de rol donde hay clientes, que solicitan un proyecto informático, y desarrolladores. En el Grado de Ingeniería Telemática (GIT), el rol de usuario final lo tomaba un único profesor, mientras que los usuarios jugaban el rol de desarrolladores. En el Grado de Ingeniería Multimedia (GIM), los estudiantes jugaban a la vez el rol de cliente y de desarrolladores (para proyectos distintos). En este artículo se abordan ambas experiencias y se presenta una comparativa de los resultados obtenidos con ellas. En el caso de GIT se garantiza que la carga de trabajo es para todos los estudiantes la misma. Además, el profesor puede llevar un seguimiento más directo al conocer de primera mano el caso a desarrollar. En el caso de GIM se potencia la creatividad de los alumnos, ya que deben inventarse el proyecto a desarrollar. Además, los alumnos aprenden a desempeñar dos roles que les pueden ser útiles en el mundo real.

[EN] Both the degree in Telematic Engineering and the degree in Multimedia Engineering have a subject of Software Engineering. One competence of this subject is to train students as professionals for the real world. For this aim, we have applied two versions of a role-playing game where there are both clients, who ask for a system development project, and developers. In the degree in Telematic Ingineering, the teacher plays the role of client, while students play the role of developers. Regarding the degree of Multimedia Engineering, students play both the role of client and developer at the same time (for different projects). In this paper, we tackle both experiences and we show a comparative of results. For Telematic Engineering, we ensure that the workload is the same for all the students. Moreover, the teacher can control directly the work of the students since he/she knows perfectly the project that needs to be developed. Regarding Multimedia Engineering, we try to enhance the students’ creativity since they must devise themselves a project to develop. Moreover, the students learn how to develop both roles, which can be useful for the real world., [ES] Dentro de los grados de Ingeniería Telemática e Ingeniería Multimedia se imparte la asignatura de Ingeniería del Software. Una de las competencias de esta asignatura es formar a los alumnos como profesionales para el mundo real. Para ello, hemos aplicado dos variantes de un juego de rol donde hay clientes, que solicitan un proyecto informático, y desarrolladores. En el Grado de Ingeniería Telemática (GIT), el rol de usuario final lo tomaba un único profesor, mientras que los usuarios jugaban el rol de desarrolladores. En el Grado de Ingeniería Multimedia (GIM), los estudiantes jugaban a la vez el rol de cliente y de desarrolladores (para proyectos distintos). En este artículo se abordan ambas experiencias y se presenta una comparativa de los resultados obtenidos con ellas. En el caso de GIT se garantiza que la carga de trabajo es para todos los estudiantes la misma. Además, el profesor puede llevar un seguimiento más directo al conocer de primera mano el caso a desarrollar. En el caso de GIM se potencia la creatividad de los alumnos, ya que deben inventarse el proyecto a desarrollar. Además, los alumnos aprenden a desempeñar dos roles que les pueden ser útiles en el mundo real.

[EN] Both the degree in Telematic Engineering and the degree in Multimedia Engineering have a subject of Software Engineering. One competence of this subject is to train students as professionals for the real world. For this aim, we have applied two versions of a role-playing game where there are both clients, who ask for a system development project, and developers. In the degree in Telematic Ingineering, the teacher plays the role of client, while students play the role of developers. Regarding the degree of Multimedia Engineering, students play both the role of client and developer at the same time (for different projects). In this paper, we tackle both experiences and we show a comparative of results. For Telematic Engineering, we ensure that the workload is the same for all the students. Moreover, the teacher can control directly the work of the students since he/she knows perfectly the project that needs to be developed. Regarding Multimedia Engineering, we try to enhance the students’ creativity since they must devise themselves a project to develop. Moreover, the students learn how to develop both roles, which can be useful for the real world., [ES] Dentro de los grados de Ingeniería Telemática e Ingeniería Multimedia se imparte la asignatura de Ingeniería del Software. Una de las competencias de esta asignatura es formar a los alumnos como profesionales para el mundo real. Para ello, hemos aplicado dos variantes de un juego de rol donde hay clientes, que solicitan un proyecto informático, y desarrolladores. En el Grado de Ingeniería Telemática (GIT), el rol de usuario final lo tomaba un único profesor, mientras que los usuarios jugaban el rol de desarrolladores. En el Grado de Ingeniería Multimedia (GIM), los estudiantes jugaban a la vez el rol de cliente y de desarrolladores (para proyectos distintos). En este artículo se abordan ambas experiencias y se presenta una comparativa de los resultados obtenidos con ellas. En el caso de GIT se garantiza que la carga de trabajo es para todos los estudiantes la misma. Además, el profesor puede llevar un seguimiento más directo al conocer de primera mano el caso a desarrollar. En el caso de GIM se potencia la creatividad de los alumnos, ya que deben inventarse el proyecto a desarrollar. Además, los alumnos aprenden a desempeñar dos roles que les pueden ser útiles en el mundo real.

Coiled-coil domain-containing 80 (CCDC80) is an adipocyte-secreted protein that modulates glucose homeostasis in response to diet-induced obesity in mice. The objective of this study was to analyze the link between human CCDC80 and obesity. CCDC80 protein expression was assessed in paired visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) from 10 patients (body mass index range 22.4-38.8 kg/m(2)). Circulating CCDC80 levels were quantified in serum samples from two independent cross-sectional cohorts comprising 33 lean and 15 obese (cohort 1) and 32 morbidly obese (cohort 2) male patients. Insulin sensitivity, insulin secretion and blood neutrophil count were quantified in serum samples from both cohorts. Additionally, circulating free insulin-like growth factor (IGF)-1 levels and oral glucose tolerance tests were assessed in cohort 1, whereas C-reactive protein levels and degree of atherosclerosis and hepatic steatosis were studied in cohort 2. In lean patients, total CCDC80 protein content assessed by immunoblotting was lower in VAT than in SAT. In obese patients, CCDC80 was increased in VAT (P < 0.05) but equivalent in SAT compared with lean counterparts. In cohort 1, serum CCDC80 correlated negatively with the acute insulin response to glucose and IGF-1 levels and positively with blood neutrophil count independent of BMI, but not with insulin sensitivity. In cohort 2, serum CCDC80 was positively linked to the inflammatory biomarker C-reactive protein (r = 0.46; P = 0.009), atherosclerosis (carotid intima-media thickness, r = 0.62; P < 0.001) and hepatic steatosis (analysis of variance P = 0.025). Overall, these results suggest for the first time that CCDC80 may be a component of the obesity-altered secretome in VAT and could act as an adipokine whose

INTRODUCTION: Lupus nephritis (LN) is a serious organ manifestation of systemic lupus erythematosus. Histologic overlap is relatively common in the six pathologic classes (I to VI) of LN. For example, mixed proliferative LN (MPLN) often includes features of classes III & V or classes IV & V combined. We performed a comparative evaluation of renal outcomes in patients with MPLN to patients with pure proliferative LN (PPLN) against pre-specified renal outcomes, and we also identified predictor of clinical outcomes among those with PPLN and MPLN. HYPOTHESIS: Individuals with MPLN will have worse short-term renal outcomes compared to those with PPLN. METHODS: We retrospectively reviewed 278 adult LN patients (≥18 years old) identified from an Emory University Hospital registry of native renal biopsies performed between January 2000 and December 2011. The final analytic sample consisted of individuals with a diagnosis of PPLN (n = 60) and MPLN (n = 96). We analyzed differences in clinical and laboratory characteristics at baseline. We also assessed associations between LN category and renal outcomes (complete remission and time to ESRD) with logistic and Cox proportional hazards models within two years of baseline. RESULTS: The study population was predominantly female (83.97%) and African American (71.8%) with a mean age of 33.4 years at baseline. Over a median follow up of 1.02 years, we did not find any statistically significant associations between MPLN and the development of ESRD or remission when compared to patients with PPLN (adjusted HR = 0.30, 95% CI = 0.07, 1.26). CONCLUSION: There was no association between mixed or pure histopathologic features of LN at presentation and rate of complete or partial remission but higher baseline eGFR was associated with a lower probability of complete remission among patients with lupus nephritis.

Cultivation of spinach requires high amounts of nitrogen (N), which puts a strain on the environment. A sustainable solution to this problem is to breed for crops with higher N use efficiency (NUE). The aim of this study was to provide tools for molecular breeding and to elucidate the genetic variation of factors contributing to NUE in spinach. A cross was made between two F1 hybrid cultivars contrasting in NUE. Several F1 progeny were self-pollinated and based on evaluation of the F2 generation, a mapping F2 population (335 individuals) of a single F1 was selected. SNP markers for the genetic map were discovered by RNA sequencing of the two parent cultivars, and 283 SNP markers were used to produce a genetic map comprising of six linkage groups (P01–P06), ranging in size from 46 to 116 cM. NUE related traits were determined for a set of F2:3 families grown under low and high N conditions in a hydroponics system under an Ingestad N-addition model. Interval mapping analysis detected 39 trait-specific QTLs, with several QTLs accumulating on P01 and P02 of the linkage map. The QTLs and in particular the P01 and P02 regions provide potential targets for the improvement of NUE in spinach.

[EN] The HCI community has developed guidelines and recommendations for improving the usability system that are usually applied at the last stages of the software development process. On the other hand, the SE community has developed sound methods to elicit functional requirements in the early stages, but usability has been relegated to the last stages together with other nonfunctional requirements. Therefore, there are no methods of usability requirements elicitation to develop software within both communities. An example of this problem arises if we focus on the Model-Driven Development paradigm, where the methods and tools that are used to develop software do not support usability requirements elicitation. In order to study the existing publications that deal with usability requirements from the first steps of the software development process, this work presents a mapping study. Our aim is to compare usability requirements methods and to identify the strong points of each one

[EN] The HCI community has developed guidelines and recommendations for improving the usability system that are usually applied at the last stages of the software development process. On the other hand, the SE community has developed sound methods to elicit functional requirements in the early stages, but usability has been relegated to the last stages together with other nonfunctional requirements. Therefore, there are no methods of usability requirements elicitation to develop software within both communities. An example of this problem arises if we focus on the Model-Driven Development paradigm, where the methods and tools that are used to develop software do not support usability requirements elicitation. In order to study the existing publications that deal with usability requirements from the first steps of the software development process, this work presents a mapping study. Our aim is to compare usability requirements methods and to identify the strong points of each one

[EN] The HCI community has developed guidelines and recommendations for improving the usability system that are usually applied at the last stages of the software development process. On the other hand, the SE community has developed sound methods to elicit functional requirements in the early stages, but usability has been relegated to the last stages together with other nonfunctional requirements. Therefore, there are no methods of usability requirements elicitation to develop software within both communities. An example of this problem arises if we focus on the Model-Driven Development paradigm, where the methods and tools that are used to develop software do not support usability requirements elicitation. In order to study the existing publications that deal with usability requirements from the first steps of the software development process, this work presents a mapping study. Our aim is to compare usability requirements methods and to identify the strong points of each one

peer-reviewed, Adiponectin is an adipokine secreted by white adipocytes involved in regulating insulin sensitivity in peripheral tissues. Secretion of adiponectin in adipocytes relies on the endosomal system, however, the intracellular machinery involved in mediating adiponectin release is unknown. We have previously reported that intracellular adiponectin partially compartmentalizes with rab 5 and rab11, markers for the early/sorting and recycling compartments respectively. Here we have examined the role of several rab11 downstream effector proteins (rab11 FIPs) in regulating adiponectin trafficking and secretion. Overexpression of wild type rab11 FIP1, FIP3 and FIP5 decreased the amount of secreted adiponectin expressed in HEK293 cells, whereas overexpression of rab11 FIP2 or FIP4 had no effect. Furthermore shRNA-mediated depletion of FIP1 enhanced adiponectin release whereas knock down of FIP5 decreased adiponectin secretion. Knock down of FIP3 had no effect. In 3T3L1 adipocytes, endogenous FIP1 co-distributed intracellularly with endogenous adiponectin and FIP1 depletion enhanced adiponectin release without altering insulin-mediated trafficking of the glucose transporter Glut4. While adiponectin receptors internalized with transferrin receptors, there were no differences in transferrin receptor recycling between wild type and FIP1 depleted adipocytes. Consistent with its inhibitory role, FIP1 expression was decreased during adipocyte differentiation, by treatment with thiazolidinediones, and with increased BMI in humans. In contrast, FIP1 expression increased upon exposure of adipocytes to TNFα. In all, our findings identify FIP1 as a novel protein involved in the regulation of adiponectin trafficking and release., PUBLISHED, peer-reviewed

The Software Engineering (SE) community has historically focused on working with models to represent functionality and persistence, pushing interaction modelling into the background, which has been covered by the Human Computer Interaction (HCI) community. Recently, adequately modelling interaction, and specifically usability, is being considered as a key factor for success in user acceptance, making the integration of the SE and HCI communities more necessary. If we focus on the Model-Driven Development (MDD) paradigm, we notice that there is a lack of proposals to deal with usability features from the very first steps of software development process. In general, usability features are manually implemented once the code has been generated from models. This contradicts the MDD paradigm, which claims that all the analysts? effort must be focused on building models, and the code generation is relegated to model to code transformations. Moreover, usability features related to functionality may involve important changes in the system architecture if they are not considered from the early steps. We state that these usability features related to functionality can be represented abstractly in a conceptual model, and their implementation can be carried out automatically.

The Software Engineering (SE) community has historically focused on working with models to represent functionality and persistence, pushing interaction modelling into the background, which has been covered by the Human Computer Interaction (HCI) community. Recently, adequately modelling interaction, and specifically usability, is being considered as a key factor for success in user acceptance, making the integration of the SE and HCI communities more necessary. If we focus on the Model-Driven Development (MDD) paradigm, we notice that there is a lack of proposals to deal with usability features from the very first steps of software development process. In general, usability features are manually implemented once the code has been generated from models. This contradicts the MDD paradigm, which claims that all the analysts? effort must be focused on building models, and the code generation is relegated to model to code transformations. Moreover, usability features related to functionality may involve important changes in the system architecture if they are not considered from the early steps. We state that these usability features related to functionality can be represented abstractly in a conceptual model, and their implementation can be carried out automatically.

Optimal lipid storage and mobilization are essential for efficient adipose tissue. Nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ) regulates adipocyte differentiation and lipid deposition, but its role in lipolysis and dysregulation in obesity is not well defined. This investigation aimed to understand the molecular impact of dysfunctional PPARγ on the lipolytic axis and to explore whether these defects are also confirmed in common forms of human obesity. For this purpose, we used the P465L PPARγ mouse as a model of dysfunctional PPARγ that recapitulates the human pparγ mutation (P467L). We demonstrated that defective PPARγ impairs catecholamine-induced lipolysis. This abnormal lipolytic response is exacerbated by a state of positive energy balance in leptin-deficient ob/ob mice. We identified the protein kinase A (PKA) network as a PPARγ-dependent regulatory node of the lipolytic response. Specifically, defective PPARγ is associated with decreased basal expression of prkaca (PKAcatα) and d-akap1, the lipase genes Pnplaz (ATGL) and Lipe (HSL), and lipid droplet protein genes fsp27 and adrp in vivo and in vitro. Our data indicate that PPARγ is required for activation of the lipolytic regulatory network, dysregulation of which is an important feature of obesity-induced insulin resistance in humans., Funding agencies:Diabetes UKMRCMITINCambridge NIHR Biomedical Research CentreFP6 HEPADIPHuman Frontier Science ProgrammeJunta de Andalucia P08-CTS-04369Fondo de Investigacion Sanitaria PS09/00997Ministerio de Educacion y Ciencia SAF2008-02073Instituto de Salud Carlos III-CIBERobn

El presente trabajo aborda la importancia de la puesta en escena fotográfica como presentación exacta de la élite y su proyecto de modernidad en América Latina, en medio de un proceso de continuación del modelo establecido por la tradición europea. Uno de los discursos más eficaces para este fin lo constituye el Manual de urbanidad y buenas maneras del venezolano Manuel Antonio Carreño. La fotografía de retrato se une a la complacencia burguesa que resuelve necesidades sociales concretas puestas al servicio de la conciencia nacional y del 'buen ciudadano'.

El presente trabajo aborda la importancia de la puesta en escena fotográfica como presentación exacta de la élite y su proyecto de modernidad en América Latina, en medio de un proceso de continuación del modelo establecido por la tradición europea. Uno de los discursos más eficaces para este fin lo constituye el Manual de urbanidad y buenas maneras del venezolano Manuel Antonio Carreño. La fotografía de retrato se une a la complacencia burguesa que resuelve necesidades sociales concretas puestas al servicio de la conciencia nacional y del 'buen ciudadano'.

Definir el concepto de realidad y como este se ve afectado por las vivencias y percepciones de cada individuo fue el punto de partido de esta investigación. En una búsqueda llegué a la noción de Bardo que, para los budistas tibetanos, corresponde a la transición entre la vida y la muerte. Con el fin de manifestar mi aproximación individual a esta noción, usé como recurso el lenguaje de la ilustración y el libro álbum. A través de este medio, realidad y fantasía dejan de contraponerse y pueden ser un complemento que logra, de alguna manera, sustentar esas problemáticas tan complejas.

Antep, Las h. pleg. de lám. son mapas. El primero del estrecho de Gibraltar y la bahía de Algeciras ; el segundo de Tarifa y la isla de las Palomas y el tercero de Ceuta y su campo

As f. de map. preg.: "Lit. Viuda de Roldán Madrid, P. Peñas grabó"