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4. A quasielastic neutron scattering investigation on the molecular self-dynamics of human myelin protein P2

Author

Laulumaa, S. (Saara), Koza, M. M. (Michael Marek), Seydel, T. (Tilo), Kursula, P. (Petri), Natali, F. (Francesca), Laulumaa, S. (Saara), Koza, M. M. (Michael Marek), Seydel, T. (Tilo), Kursula, P. (Petri), and Natali, F. (Francesca)

Abstract

The human myelin protein P2 is a membrane binding protein believed to maintain correct lipid composition and organization in peripheral nerve myelin. Its function is related to its ability to stack membranes, and this function can be enhanced by the P38G mutation, whereby the overall protein structure does not change but the molecular dynamics increase. Mutations in P2 are linked to human peripheral neuropathy. Here, the dynamics of wild-type P2 and the P38G variant were studied using quasielastic neutron scattering on time scales from 10 ps to 1 ns at 300 K. The results suggest that the mutant protein dynamics are increased on both the fastest and the slowest measured time scales, by increasing the dynamics amplitude and/or the portion of atoms participating in the movement.

Published
2019

5. Flexibility and drug release features of lipid/saccharide nanoparticles

Author

Gerelli, Y, Di Bari, MT, Barbieri, S, Sonvico, F, Colombo, P, Natali, F, Deriu, A, Gerelli, Y, Di Bari, MT, Barbieri, S, Sonvico, F, Colombo, P, Natali, F, and Deriu, A

Abstract

The effect of lipophilic additives (excipients and drugs) on the behavior of lipid/saccharide nanoparticles has been investigated by incoherent elastic neutron scattering. Temperature scans from 20 K to 350 K have been performed on lecithin/chitosan particles loaded with isopropyl myristate and cetyl-stearyl alcohol, two lipophilic molecules with different melting temperatures which are commonly added to improve drug loading efficiency. In a similar way the effect of tamoxifen citrate, a lipophilic drug frequently used in breast cancer therapy, has also been studied. The different melting points of the two excipients affect mostly the low-temperature behavior of the nanoparticles. At physiological temperatures they both improve the particle flexibility. On the other hand addition of tamoxifen leads to stiffer structures and to lower amounts of released drug. The macroscopic features of the drug release appear to be correlated to the microscopic flexibility determined by neutron scattering. The data confirm also the role of chitosan as a stiffening and stabilizing agent of the lipid particles. © 2010 The Royal Society of Chemistry.

Published
2010

6. Flexibility and drug release features of lipid/saccharide nanoparticles

Author

Gerelli, Y, Di Bari, MT, Barbieri, S, Sonvico, F, Colombo, P, Natali, F, Deriu, A, Gerelli, Y, Di Bari, MT, Barbieri, S, Sonvico, F, Colombo, P, Natali, F, and Deriu, A

Abstract

The effect of lipophilic additives (excipients and drugs) on the behavior of lipid/saccharide nanoparticles has been investigated by incoherent elastic neutron scattering. Temperature scans from 20 K to 350 K have been performed on lecithin/chitosan particles loaded with isopropyl myristate and cetyl-stearyl alcohol, two lipophilic molecules with different melting temperatures which are commonly added to improve drug loading efficiency. In a similar way the effect of tamoxifen citrate, a lipophilic drug frequently used in breast cancer therapy, has also been studied. The different melting points of the two excipients affect mostly the low-temperature behavior of the nanoparticles. At physiological temperatures they both improve the particle flexibility. On the other hand addition of tamoxifen leads to stiffer structures and to lower amounts of released drug. The macroscopic features of the drug release appear to be correlated to the microscopic flexibility determined by neutron scattering. The data confirm also the role of chitosan as a stiffening and stabilizing agent of the lipid particles. © 2010 The Royal Society of Chemistry.

Published
2010

7. New sources and instrumentation for neutrons in biology

Author

Teixeira, S. C. M., Zaccai, G., Ankner, J., Bellissent-Funel, M. C., Bewley, R., Blakeley, M. P., Callow, P., Coates, L., Dahint, R., Dalgliesh, R., Dencher, N. A., Forsyth, V. T., Fragneto, G., Frick, B., Gilles, R., Gutberlet, T., Haertlein, M., Hauss, T., Haeussler, W., Heller, W. T., Herwig, K., Holderer, O., Juranyi, F., Kampmann, R., Knott, R., Krueger, S., Langan, P., Lechner, R. E., Lynn, G., Majkrzak, C., May, R. P., Meilleur, F., Mo, Y., Mortensen, Kell, Myles, D. A. A., Natali, F., Neylon, C., Niimura, N., Ollivier, J., Ostermann, A., Peters, J., Pieper, J., Ruehm, A., Schwahn, D., Shibata, K., Soper, A. K., Straessle, Th., Suzuki, J., Tanaka, I., Tehei, M., Timmins, P., Torikai, N., Unruh, T., Urban, V., Vavrin, R., Weiss, K., Teixeira, S. C. M., Zaccai, G., Ankner, J., Bellissent-Funel, M. C., Bewley, R., Blakeley, M. P., Callow, P., Coates, L., Dahint, R., Dalgliesh, R., Dencher, N. A., Forsyth, V. T., Fragneto, G., Frick, B., Gilles, R., Gutberlet, T., Haertlein, M., Hauss, T., Haeussler, W., Heller, W. T., Herwig, K., Holderer, O., Juranyi, F., Kampmann, R., Knott, R., Krueger, S., Langan, P., Lechner, R. E., Lynn, G., Majkrzak, C., May, R. P., Meilleur, F., Mo, Y., Mortensen, Kell, Myles, D. A. A., Natali, F., Neylon, C., Niimura, N., Ollivier, J., Ostermann, A., Peters, J., Pieper, J., Ruehm, A., Schwahn, D., Shibata, K., Soper, A. K., Straessle, Th., Suzuki, J., Tanaka, I., Tehei, M., Timmins, P., Torikai, N., Unruh, T., Urban, V., Vavrin, R., and Weiss, K.

Published
2008

8. New sources and instrumentation for neutrons in biology

Author

Teixeira, S. C. M., Zaccai, G., Ankner, J., Bellissent-Funel, M. C., Bewley, R., Blakeley, M. P., Callow, P., Coates, L., Dahint, R., Dalgliesh, R., Dencher, N. A., Forsyth, V. T., Fragneto, G., Frick, B., Gilles, R., Gutberlet, T., Haertlein, M., Hauss, T., Haeussler, W., Heller, W. T., Herwig, K., Holderer, O., Juranyi, F., Kampmann, R., Knott, R., Krueger, S., Langan, P., Lechner, R. E., Lynn, G., Majkrzak, C., May, R. P., Meilleur, F., Mo, Y., Mortensen, Kell, Myles, D. A. A., Natali, F., Neylon, C., Niimura, N., Ollivier, J., Ostermann, A., Peters, J., Pieper, J., Ruehm, A., Schwahn, D., Shibata, K., Soper, A. K., Straessle, Th., Suzuki, J., Tanaka, I., Tehei, M., Timmins, P., Torikai, N., Unruh, T., Urban, V., Vavrin, R., Weiss, K., Teixeira, S. C. M., Zaccai, G., Ankner, J., Bellissent-Funel, M. C., Bewley, R., Blakeley, M. P., Callow, P., Coates, L., Dahint, R., Dalgliesh, R., Dencher, N. A., Forsyth, V. T., Fragneto, G., Frick, B., Gilles, R., Gutberlet, T., Haertlein, M., Hauss, T., Haeussler, W., Heller, W. T., Herwig, K., Holderer, O., Juranyi, F., Kampmann, R., Knott, R., Krueger, S., Langan, P., Lechner, R. E., Lynn, G., Majkrzak, C., May, R. P., Meilleur, F., Mo, Y., Mortensen, Kell, Myles, D. A. A., Natali, F., Neylon, C., Niimura, N., Ollivier, J., Ostermann, A., Peters, J., Pieper, J., Ruehm, A., Schwahn, D., Shibata, K., Soper, A. K., Straessle, Th., Suzuki, J., Tanaka, I., Tehei, M., Timmins, P., Torikai, N., Unruh, T., Urban, V., Vavrin, R., and Weiss, K.

Published
2008

9. New sources and instrumentation for neutrons in biology (vol 345, pg 133, 2008)

Author

Teixeira, S. C. M., Zaccai, G., Ankner, J., Bellissent-Funel, M. C., Bewley, R., Blakeley, M. P., Callow, P., Coates, L., Dahint, R., Dalgliesh, R., Dencher, N. A., Forsyth, V. T., Fragneto, G., Frick, B., Gilles, R., Gutberlet, T., Haertlein, M., Hauss, T., Haeussler, W., Heller, W. T., Herwig, K., Holderer, O., Juranyi, F., Kampmann, R., Knott, R., Krueger, S., Langan, P., Lechner, R. E., Lynn, G., Majkrzak, C., May, R. P., Meilleur, F., Mo, Y., Mortensen, Kell, Myles, D. A. A., Natali, F., Neylon, C., Niimura, N., Ollivier, J., Ostermann, A., Peters, J., Pieper, J., Ruehm, A., Schwahn, D., Shibata, K., Soper, A. K., Straessle, Th., Suzuki, J., Tanaka, I., Tehei, M., Timmins, P., Torikai, N., Unruh, T., Urban, V., Vavrin, R., Weiss, K., Teixeira, S. C. M., Zaccai, G., Ankner, J., Bellissent-Funel, M. C., Bewley, R., Blakeley, M. P., Callow, P., Coates, L., Dahint, R., Dalgliesh, R., Dencher, N. A., Forsyth, V. T., Fragneto, G., Frick, B., Gilles, R., Gutberlet, T., Haertlein, M., Hauss, T., Haeussler, W., Heller, W. T., Herwig, K., Holderer, O., Juranyi, F., Kampmann, R., Knott, R., Krueger, S., Langan, P., Lechner, R. E., Lynn, G., Majkrzak, C., May, R. P., Meilleur, F., Mo, Y., Mortensen, Kell, Myles, D. A. A., Natali, F., Neylon, C., Niimura, N., Ollivier, J., Ostermann, A., Peters, J., Pieper, J., Ruehm, A., Schwahn, D., Shibata, K., Soper, A. K., Straessle, Th., Suzuki, J., Tanaka, I., Tehei, M., Timmins, P., Torikai, N., Unruh, T., Urban, V., Vavrin, R., and Weiss, K.

Published
2008

10. New sources and instrumentation for neutrons in biology (vol 345, pg 133, 2008)

Author

Teixeira, S. C. M., Zaccai, G., Ankner, J., Bellissent-Funel, M. C., Bewley, R., Blakeley, M. P., Callow, P., Coates, L., Dahint, R., Dalgliesh, R., Dencher, N. A., Forsyth, V. T., Fragneto, G., Frick, B., Gilles, R., Gutberlet, T., Haertlein, M., Hauss, T., Haeussler, W., Heller, W. T., Herwig, K., Holderer, O., Juranyi, F., Kampmann, R., Knott, R., Krueger, S., Langan, P., Lechner, R. E., Lynn, G., Majkrzak, C., May, R. P., Meilleur, F., Mo, Y., Mortensen, Kell, Myles, D. A. A., Natali, F., Neylon, C., Niimura, N., Ollivier, J., Ostermann, A., Peters, J., Pieper, J., Ruehm, A., Schwahn, D., Shibata, K., Soper, A. K., Straessle, Th., Suzuki, J., Tanaka, I., Tehei, M., Timmins, P., Torikai, N., Unruh, T., Urban, V., Vavrin, R., Weiss, K., Teixeira, S. C. M., Zaccai, G., Ankner, J., Bellissent-Funel, M. C., Bewley, R., Blakeley, M. P., Callow, P., Coates, L., Dahint, R., Dalgliesh, R., Dencher, N. A., Forsyth, V. T., Fragneto, G., Frick, B., Gilles, R., Gutberlet, T., Haertlein, M., Hauss, T., Haeussler, W., Heller, W. T., Herwig, K., Holderer, O., Juranyi, F., Kampmann, R., Knott, R., Krueger, S., Langan, P., Lechner, R. E., Lynn, G., Majkrzak, C., May, R. P., Meilleur, F., Mo, Y., Mortensen, Kell, Myles, D. A. A., Natali, F., Neylon, C., Niimura, N., Ollivier, J., Ostermann, A., Peters, J., Pieper, J., Ruehm, A., Schwahn, D., Shibata, K., Soper, A. K., Straessle, Th., Suzuki, J., Tanaka, I., Tehei, M., Timmins, P., Torikai, N., Unruh, T., Urban, V., Vavrin, R., and Weiss, K.

Published
2008

11. New sources and instrumentation for neutrons in biology

Author

Teixeira, S.C.M., Zaccai, G., Ankner, J., Bellissent-Funel, M.C., Bewley, R., Blakeley, M.P., Callow, P., Coates, L., Dahint, R., Dalgleish, R., Dencher, N.A., Forsyth, V.T., Fragneto, G., Frick, B., Gilles, R., Gurburlet, T., Haertlein, M., Hauss, T., Häußler, W., Heller, W.T., Herwig, K., Holderer, O., Juranyi, F., Kampmann, R., Knott, R., Krueger, S., Langan, P., Lechner, R.E., Lynn, G., Majkrzak, C., May, R.P., Meilleur, F., Mo, Y., Mortensen, Kell, Myles, D.A.A., Natali, F., Neylon, C., Niimura, N., Ollivier, J., Ostermann, A., Peters, J., Pieper, J., Rühm, A., Schwahn, D., Shibata, K., Soper, A.K., Strässle, T., Suzuki, J., Tanaka, I., Tehei, M., Timmins, P., Torikai, N., Unruh, T., Urban, V., Vavrin, R., Weiss, K., Teixeira, S.C.M., Zaccai, G., Ankner, J., Bellissent-Funel, M.C., Bewley, R., Blakeley, M.P., Callow, P., Coates, L., Dahint, R., Dalgleish, R., Dencher, N.A., Forsyth, V.T., Fragneto, G., Frick, B., Gilles, R., Gurburlet, T., Haertlein, M., Hauss, T., Häußler, W., Heller, W.T., Herwig, K., Holderer, O., Juranyi, F., Kampmann, R., Knott, R., Krueger, S., Langan, P., Lechner, R.E., Lynn, G., Majkrzak, C., May, R.P., Meilleur, F., Mo, Y., Mortensen, Kell, Myles, D.A.A., Natali, F., Neylon, C., Niimura, N., Ollivier, J., Ostermann, A., Peters, J., Pieper, J., Rühm, A., Schwahn, D., Shibata, K., Soper, A.K., Strässle, T., Suzuki, J., Tanaka, I., Tehei, M., Timmins, P., Torikai, N., Unruh, T., Urban, V., Vavrin, R., and Weiss, K.

Abstract

Neutron radiation offers significant advantages for the study of biological molecular structure and dynamics. A broad and significant effort towards instrumental and methodological development to facilitate biology experiments at neutron sources worldwide is reviewed., Neutron radiation offers significant advantages for the study of biological molecular structure and dynamics. A broad and significant effort towards instrumental and methodological development to facilitate biology experiments at neutron sources worldwide is reviewed.

Published
2008

12. New sources and instrumentation for neutrons in biology

Author

Teixeira, S.C.M., Zaccai, G., Ankner, J., Bellissent-Funel, M.C., Bewley, R., Blakeley, M.P., Callow, P., Coates, L., Dahint, R., Dalgleish, R., Dencher, N.A., Forsyth, V.T., Fragneto, G., Frick, B., Gilles, R., Gurburlet, T., Haertlein, M., Hauss, T., Häußler, W., Heller, W.T., Herwig, K., Holderer, O., Juranyi, F., Kampmann, R., Knott, R., Krueger, S., Langan, P., Lechner, R.E., Lynn, G., Majkrzak, C., May, R.P., Meilleur, F., Mo, Y., Mortensen, Kell, Myles, D.A.A., Natali, F., Neylon, C., Niimura, N., Ollivier, J., Ostermann, A., Peters, J., Pieper, J., Rühm, A., Schwahn, D., Shibata, K., Soper, A.K., Strässle, T., Suzuki, J., Tanaka, I., Tehei, M., Timmins, P., Torikai, N., Unruh, T., Urban, V., Vavrin, R., Weiss, K., Teixeira, S.C.M., Zaccai, G., Ankner, J., Bellissent-Funel, M.C., Bewley, R., Blakeley, M.P., Callow, P., Coates, L., Dahint, R., Dalgleish, R., Dencher, N.A., Forsyth, V.T., Fragneto, G., Frick, B., Gilles, R., Gurburlet, T., Haertlein, M., Hauss, T., Häußler, W., Heller, W.T., Herwig, K., Holderer, O., Juranyi, F., Kampmann, R., Knott, R., Krueger, S., Langan, P., Lechner, R.E., Lynn, G., Majkrzak, C., May, R.P., Meilleur, F., Mo, Y., Mortensen, Kell, Myles, D.A.A., Natali, F., Neylon, C., Niimura, N., Ollivier, J., Ostermann, A., Peters, J., Pieper, J., Rühm, A., Schwahn, D., Shibata, K., Soper, A.K., Strässle, T., Suzuki, J., Tanaka, I., Tehei, M., Timmins, P., Torikai, N., Unruh, T., Urban, V., Vavrin, R., and Weiss, K.

Abstract

Neutron radiation offers significant advantages for the study of biological molecular structure and dynamics. A broad and significant effort towards instrumental and methodological development to facilitate biology experiments at neutron sources worldwide is reviewed., Neutron radiation offers significant advantages for the study of biological molecular structure and dynamics. A broad and significant effort towards instrumental and methodological development to facilitate biology experiments at neutron sources worldwide is reviewed.

Published
2008

13. Was the Whirlpool (M51) a Spiral Galaxy before the Encounter with the Companion NGC 5195?

Author

Natali, F., Di Fino, L., Natali, G., Natali, F., Di Fino, L., and Natali, G.

Abstract

Using the B-I color index in the radial photometry of M51, applied to defined azimuthal sectors, we reveals asymmetries in the shape of the density pattern of the galactic arms. The anomalous shape is present only in the side close to the companion and not in the far side. Two more non-interacting check-spirals do not show similar behaviour. The anomalous sawtooth-like shape is similar to that produced by a progressive wave propagating in a preexisting density pattern. In this hypothesis we have to conclude that the galaxy M51 could be a spiral galaxy formerly, i.e. before the encounter with the companion., Comment: 8 pages, Latex2e, 7 eps_figures, added ackowledgements and minor revisions to the abstract

Published
2000

14. Was the Whirlpool (M51) a Spiral Galaxy before the Encounter with the Companion NGC 5195?

Author

Natali, F., Di Fino, L., Natali, G., Natali, F., Di Fino, L., and Natali, G.

Abstract

Using the B-I color index in the radial photometry of M51, applied to defined azimuthal sectors, we reveals asymmetries in the shape of the density pattern of the galactic arms. The anomalous shape is present only in the side close to the companion and not in the far side. Two more non-interacting check-spirals do not show similar behaviour. The anomalous sawtooth-like shape is similar to that produced by a progressive wave propagating in a preexisting density pattern. In this hypothesis we have to conclude that the galaxy M51 could be a spiral galaxy formerly, i.e. before the encounter with the companion., Comment: 8 pages, Latex2e, 7 eps_figures, added ackowledgements and minor revisions to the abstract

Published
2000

15. The Optical-UV Continuum of a Sample of QSOs

Author

Natali, F., Giallongo, E., Cristiani, S., La Franca, F., Natali, F., Giallongo, E., Cristiani, S., and La Franca, F.

Abstract

The average optical-UV continuum shape of QSOs has been investigated using spectra of 62 QSOs having good relative photometric calibrations. The QSO spectra were extracted from two complete color selected samples in the magnitude intervals B ~ 16-20. The analysis was performed fitting power-law continua (f proportional to nu^(alpha)) in well defined rest-frame wavelength intervals after removing regions of the spectrum affected by strong emission lines or weak emission bumps. The average slope in the rest-frame optical-UV region 1200 - 5500 A shows a rapid change around the 3000 A emission bump with alpha=0.15 longward of it and alpha=-0.65 at shorter wavelengths. Although these average slopes have been obtained using spectra of QSOs with different luminosities and redshifts, there are no significant correlations of the average spectral index with these quantities. For a few QSOs in the sample we were able to measure the same softening of the spectral shape within the individual spectrum. These results have significant consequences on the estimate of the cosmological evolution of the optically selected QSOs as they affect, for instance, the k-corrections. New k-corrections in the B, V, R and Gr bands were computed. The derived average spectral shape in the optical-UV band puts interesting constraints on the expected emission mechanisms., Comment: 12 pages. To appear in the Astronomical Journal

Published
1997
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16. The Optical-UV Continuum of a Sample of QSOs

Author

Natali, F., Giallongo, E., Cristiani, S., La Franca, F., Natali, F., Giallongo, E., Cristiani, S., and La Franca, F.

Abstract

The average optical-UV continuum shape of QSOs has been investigated using spectra of 62 QSOs having good relative photometric calibrations. The QSO spectra were extracted from two complete color selected samples in the magnitude intervals B ~ 16-20. The analysis was performed fitting power-law continua (f proportional to nu^(alpha)) in well defined rest-frame wavelength intervals after removing regions of the spectrum affected by strong emission lines or weak emission bumps. The average slope in the rest-frame optical-UV region 1200 - 5500 A shows a rapid change around the 3000 A emission bump with alpha=0.15 longward of it and alpha=-0.65 at shorter wavelengths. Although these average slopes have been obtained using spectra of QSOs with different luminosities and redshifts, there are no significant correlations of the average spectral index with these quantities. For a few QSOs in the sample we were able to measure the same softening of the spectral shape within the individual spectrum. These results have significant consequences on the estimate of the cosmological evolution of the optically selected QSOs as they affect, for instance, the k-corrections. New k-corrections in the B, V, R and Gr bands were computed. The derived average spectral shape in the optical-UV band puts interesting constraints on the expected emission mechanisms., Comment: 12 pages. To appear in the Astronomical Journal

Published
1997
Full Text
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17. Investigation of a Preliminary GPS Receiver Design for General Aviation.

Author

STANFORD TELECOMMUNICATIONS INC MCLEAN VA, Elrod,B D, Natali,F D, STANFORD TELECOMMUNICATIONS INC MCLEAN VA, Elrod,B D, and Natali,F D

Abstract

The preliminary design and analysis of a potentially low cost GPS receiver for general aviation navigation applications is presented. The results indicate that the receiver could meet or exceed 2D area navigation (RNAV) requirements without dependence on external altitude data. (Author)

Published
1978

18. Decay of solutions to damped Korteweg-de Vries type equation

Author

Cavalcanti M.M., Cavalcanti V.N.D., Faminskii A., Natali F., Cavalcanti M.M., Cavalcanti V.N.D., Faminskii A., and Natali F.

Abstract

In the present paper we establish results concerning the decay of the energy related to the damped Korteweg-de Vries equation posed on infinite domains. We prove the exponential decay rates of the energy when a initial value problem and a localized dissipative mechanism are in place. If this mechanism is effective in the whole line, we get a similar result in H k-level, k ∈ N. In addition, the decay of the energy regarding a initial boundary value problem posed on the right half-line, is obtained considering convenient a smallness condition on the initial data but a more general dissipative effect. © Springer Science+Business Media, LLC 2011.

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