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1. Cruciferous Vegetable Intake and Bulky DNA Damage within Non-Smokers and Former Smokers in the Gen-Air Study (EPIC Cohort)

Author

Peluso, Marco, Munnia, Armelle, Russo, Valentina, Galli, Andrea, Pala, Valeria, van der Schouw, Yvonne T., Schulze, Matthias B., Weiderpass, Elisabete, Tumino, Rosario, Saieva, Calogero, Exezarreta Pilar, Amiano, Aune, Dagfinn, Heath, Alicia K., Aglago, Elom, Agudo, Antonio, Panico, Salvatore, Petersen, Kristina Elin Nielsen, Tjonneland, Anne, Cirera, Lluis, Rodriguez-Barranco, Miguel, Katzke, Verena, Kaaks, Rudolf, Ricceri, Fulvio, Milani, Lorenzo, Vineis, Paolo, Sacerdote, Carlotta, Peluso, Marco, Munnia, Armelle, Russo, Valentina, Galli, Andrea, Pala, Valeria, van der Schouw, Yvonne T., Schulze, Matthias B., Weiderpass, Elisabete, Tumino, Rosario, Saieva, Calogero, Exezarreta Pilar, Amiano, Aune, Dagfinn, Heath, Alicia K., Aglago, Elom, Agudo, Antonio, Panico, Salvatore, Petersen, Kristina Elin Nielsen, Tjonneland, Anne, Cirera, Lluis, Rodriguez-Barranco, Miguel, Katzke, Verena, Kaaks, Rudolf, Ricceri, Fulvio, Milani, Lorenzo, Vineis, Paolo, and Sacerdote, Carlotta

Abstract

Epidemiologic studies have indicated that cruciferous vegetables can influence the cancer risk; therefore, we examined with a cross-sectional approach the correlation between the frequent consumption of the total cruciferous vegetables and the formation of bulky DNA damage, a biomarker of carcinogen exposure and cancer risk, in the Gen-Air study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. DNA damage measurements were performed in the peripheral blood of 696 of those apparently healthy without cancer controls, including 379 never-smokers and 317 former smokers from seven European countries by the P-32-postlabeling assay. In the Gen-Air controls, the median intake of cruciferous vegetables was 6.16 (IQR 1.16-13.66) g/day, ranging from 0.37 (IQR 0-6.00) g/day in Spain to 11.34 (IQR 6.02-16.07) g/day in the UK. Based on this information, participants were grouped into: (a) high consumers (>20 g/day), (b) medium consumers (3-20 g/day) and (c) low consumers (

Published
2022

2. Cruciferous Vegetable Intake and Bulky DNA Damage within Non-Smokers and Former Smokers in the Gen-Air Study (EPIC Cohort)

Author

Peluso, Marco, Munnia, Armelle, Russo, Valentina, Galli, Andrea, Pala, Valeria, van der Schouw, Yvonne T., Schulze, Matthias B., Weiderpass, Elisabete, Tumino, Rosario, Saieva, Calogero, Exezarreta Pilar, Amiano, Aune, Dagfinn, Heath, Alicia K., Aglago, Elom, Agudo, Antonio, Panico, Salvatore, Petersen, Kristina Elin Nielsen, Tjonneland, Anne, Cirera, Lluis, Rodriguez-Barranco, Miguel, Katzke, Verena, Kaaks, Rudolf, Ricceri, Fulvio, Milani, Lorenzo, Vineis, Paolo, Sacerdote, Carlotta, Peluso, Marco, Munnia, Armelle, Russo, Valentina, Galli, Andrea, Pala, Valeria, van der Schouw, Yvonne T., Schulze, Matthias B., Weiderpass, Elisabete, Tumino, Rosario, Saieva, Calogero, Exezarreta Pilar, Amiano, Aune, Dagfinn, Heath, Alicia K., Aglago, Elom, Agudo, Antonio, Panico, Salvatore, Petersen, Kristina Elin Nielsen, Tjonneland, Anne, Cirera, Lluis, Rodriguez-Barranco, Miguel, Katzke, Verena, Kaaks, Rudolf, Ricceri, Fulvio, Milani, Lorenzo, Vineis, Paolo, and Sacerdote, Carlotta

Abstract

Epidemiologic studies have indicated that cruciferous vegetables can influence the cancer risk; therefore, we examined with a cross-sectional approach the correlation between the frequent consumption of the total cruciferous vegetables and the formation of bulky DNA damage, a biomarker of carcinogen exposure and cancer risk, in the Gen-Air study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. DNA damage measurements were performed in the peripheral blood of 696 of those apparently healthy without cancer controls, including 379 never-smokers and 317 former smokers from seven European countries by the P-32-postlabeling assay. In the Gen-Air controls, the median intake of cruciferous vegetables was 6.16 (IQR 1.16-13.66) g/day, ranging from 0.37 (IQR 0-6.00) g/day in Spain to 11.34 (IQR 6.02-16.07) g/day in the UK. Based on this information, participants were grouped into: (a) high consumers (>20 g/day), (b) medium consumers (3-20 g/day) and (c) low consumers (

Published
2022

3. Cruciferous Vegetable Intake and Bulky DNA Damage within Non-Smokers and Former Smokers in the Gen-Air Study (EPIC Cohort)

Author

Cardiovasculaire Epi Team 1, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Peluso, Marco, Munnia, Armelle, Russo, Valentina, Galli, Andrea, Pala, Valeria, Schouw, Yvonne T van der, Schulze, Matthias B, Weiderpass, Elisabete, Tumino, Rosario, Saieva, Calogero, Exezarreta Pilar, Amiano, Aune, Dagfinn, Heath, Alicia K, Aglago, Elom, Agudo, Antonio, Panico, Salvatore, Petersen, Kristina Elin Nielsen, Tjønneland, Anne, Cirera, Lluís, Rodriguez-Barranco, Miguel, Katzke, Verena, Kaaks, Rudolf, Ricceri, Fulvio, Milani, Lorenzo, Vineis, Paolo, Sacerdote, Carlotta, Cardiovasculaire Epi Team 1, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Peluso, Marco, Munnia, Armelle, Russo, Valentina, Galli, Andrea, Pala, Valeria, Schouw, Yvonne T van der, Schulze, Matthias B, Weiderpass, Elisabete, Tumino, Rosario, Saieva, Calogero, Exezarreta Pilar, Amiano, Aune, Dagfinn, Heath, Alicia K, Aglago, Elom, Agudo, Antonio, Panico, Salvatore, Petersen, Kristina Elin Nielsen, Tjønneland, Anne, Cirera, Lluís, Rodriguez-Barranco, Miguel, Katzke, Verena, Kaaks, Rudolf, Ricceri, Fulvio, Milani, Lorenzo, Vineis, Paolo, and Sacerdote, Carlotta

Published
2022

4. Decreased nucleotide excision repair in steatotic livers associates with myeloperoxidase-immunoreactivity.

Author

Schults, M.A.C., Schults, M.A.C., Nagle, P.W., Rensen, S.S.M., Godschalk, R.W.L., Munnia, A., Peluso, M., Claessen, S. M., Greve, J.W., Driessen, A.L.C., Verdam, F.J., Buurman, W.A., van Schooten, F.J., Chiu, R.K., Schults, M.A.C., Schults, M.A.C., Nagle, P.W., Rensen, S.S.M., Godschalk, R.W.L., Munnia, A., Peluso, M., Claessen, S. M., Greve, J.W., Driessen, A.L.C., Verdam, F.J., Buurman, W.A., van Schooten, F.J., and Chiu, R.K.

Abstract

Chronic inflammation is characterized by the influx of neutrophils and is associated with an increased production of reactive oxygen species that can damage DNA. Oxidative DNA damage is generally thought to be involved in the increased risk of cancer in inflamed tissues. We previously demonstrated that activated neutrophil mediated oxidative stress results in a reduction in nucleotide excision repair (NER) capacity, which could further enhance mutagenesis. Inflammation and oxidative stress are critical factors in the progression of nonalcoholic fatty liver disease that is linked with enhanced liver cancer risk. In this report, we therefore evaluated the role of neutrophils and the associated oxidative stress in damage recognition and DNA repair in steatotic livers of 35 severely obese subjects with either nonalcoholic steatohepatitis (NASH) (n=17) or steatosis alone (n=18). The neutrophilic influx in liver was assessed by myeloperoxidase (MPO) staining and the amount of oxidative DNA damage by measuring M(1)dG adducts. No differences in M(1)dG adduct levels were observed between patients with or without NASH and also not between individuals with high or low MPO immunoreactivity. However, we found that high expression of MPO in the liver, irrespective of disease status, reduced the damage recognition capacity as determined by staining for histone 2AX phosphorylation (gammaH2AX). This reduction in gammaH2AX formation in individuals with high MPO immunoreactivity was paralleled by a significant decrease in NER capacity as assessed by a functional repair assay, and was not related to cell proliferation. Thus, the observed reduction in NER capacity upon hepatic inflammation is associated with and may be a consequence of reduced damage recognition. These findings suggest a novel mechanism of liver cancer development in patients with nonalcoholic fatty liver disease.

Published
2012

5. Decreased nucleotide excision repair in steatotic livers associates with myeloperoxidase-immunoreactivity.

Author

Schults, M.A.C., Nagle, P.W., Rensen, S.S.M., Godschalk, R.W.L., Munnia, A., Peluso, M., Claessen, S. M., Greve, J.W., Driessen, A.L.C., Verdam, F.J., Buurman, W.A., van Schooten, F.J., Chiu, R.K., Schults, M.A.C., Nagle, P.W., Rensen, S.S.M., Godschalk, R.W.L., Munnia, A., Peluso, M., Claessen, S. M., Greve, J.W., Driessen, A.L.C., Verdam, F.J., Buurman, W.A., van Schooten, F.J., and Chiu, R.K.

Abstract

Chronic inflammation is characterized by the influx of neutrophils and is associated with an increased production of reactive oxygen species that can damage DNA. Oxidative DNA damage is generally thought to be involved in the increased risk of cancer in inflamed tissues. We previously demonstrated that activated neutrophil mediated oxidative stress results in a reduction in nucleotide excision repair (NER) capacity, which could further enhance mutagenesis. Inflammation and oxidative stress are critical factors in the progression of nonalcoholic fatty liver disease that is linked with enhanced liver cancer risk. In this report, we therefore evaluated the role of neutrophils and the associated oxidative stress in damage recognition and DNA repair in steatotic livers of 35 severely obese subjects with either nonalcoholic steatohepatitis (NASH) (n=17) or steatosis alone (n=18). The neutrophilic influx in liver was assessed by myeloperoxidase (MPO) staining and the amount of oxidative DNA damage by measuring M(1)dG adducts. No differences in M(1)dG adduct levels were observed between patients with or without NASH and also not between individuals with high or low MPO immunoreactivity. However, we found that high expression of MPO in the liver, irrespective of disease status, reduced the damage recognition capacity as determined by staining for histone 2AX phosphorylation (gammaH2AX). This reduction in gammaH2AX formation in individuals with high MPO immunoreactivity was paralleled by a significant decrease in NER capacity as assessed by a functional repair assay, and was not related to cell proliferation. Thus, the observed reduction in NER capacity upon hepatic inflammation is associated with and may be a consequence of reduced damage recognition. These findings suggest a novel mechanism of liver cancer development in patients with nonalcoholic fatty liver disease.

Published
2012

6. Bulky DNA adducts in white blood cells: a pooled analysis of 3,600 subjects.

Author

Risk Assessment of Toxic and Immunomodulatory Agents, Dep IRAS, Ricceri, F., Godschalk, R.W., Peluso, M., Phillips, D.H., Agudo, A, Georgiadis, P., Loft, S., Tjonneland, A., Raaschou-Nielsen, O., Palli, D., Perera, F., Vermeulen, R., Taioli, E., Sram, R.J., Munnia, A., Rosa, F., Allione, A., Matullo, G., Vineis, P., Risk Assessment of Toxic and Immunomodulatory Agents, Dep IRAS, Ricceri, F., Godschalk, R.W., Peluso, M., Phillips, D.H., Agudo, A, Georgiadis, P., Loft, S., Tjonneland, A., Raaschou-Nielsen, O., Palli, D., Perera, F., Vermeulen, R., Taioli, E., Sram, R.J., Munnia, A., Rosa, F., Allione, A., Matullo, G., and Vineis, P.

Published
2010

7. Bulky DNA adducts in white blood cells: a pooled analysis of 3,600 subjects.

Author

Risk Assessment of Toxic and Immunomodulatory Agents, Dep IRAS, Ricceri, F., Godschalk, R.W., Peluso, M., Phillips, D.H., Agudo, A, Georgiadis, P., Loft, S., Tjonneland, A., Raaschou-Nielsen, O., Palli, D., Perera, F., Vermeulen, R., Taioli, E., Sram, R.J., Munnia, A., Rosa, F., Allione, A., Matullo, G., Vineis, P., Risk Assessment of Toxic and Immunomodulatory Agents, Dep IRAS, Ricceri, F., Godschalk, R.W., Peluso, M., Phillips, D.H., Agudo, A, Georgiadis, P., Loft, S., Tjonneland, A., Raaschou-Nielsen, O., Palli, D., Perera, F., Vermeulen, R., Taioli, E., Sram, R.J., Munnia, A., Rosa, F., Allione, A., Matullo, G., and Vineis, P.

Published
2010

8. Bulky DNA adducts in white blood cells: a pooled analysis of 3,600 subjects.

Author

Risk Assessment of Toxic and Immunomodulatory Agents, Dep IRAS, Ricceri, F., Godschalk, R.W., Peluso, M., Phillips, D.H., Agudo, A, Georgiadis, P., Loft, S., Tjonneland, A., Raaschou-Nielsen, O., Palli, D., Perera, F., Vermeulen, R., Taioli, E., Sram, R.J., Munnia, A., Rosa, F., Allione, A., Matullo, G., Vineis, P., Risk Assessment of Toxic and Immunomodulatory Agents, Dep IRAS, Ricceri, F., Godschalk, R.W., Peluso, M., Phillips, D.H., Agudo, A, Georgiadis, P., Loft, S., Tjonneland, A., Raaschou-Nielsen, O., Palli, D., Perera, F., Vermeulen, R., Taioli, E., Sram, R.J., Munnia, A., Rosa, F., Allione, A., Matullo, G., and Vineis, P.

Published
2010

9. Bulky DNA adducts in white blood cells: a pooled analysis of 3,600 subjects

Author

Ricceri, Fulvio, Godschalk, Roger W, Peluso, Marco, Phillips, David H, Agudo, Antonio, Georgiadis, Panagiotis, Loft, Steffen, Tjønneland, Anne, Raaschou-Nielsen, Ole, Palli, Domenico, Perera, Frederica, Vermeulen, Roel, Taioli, Emanuela, Sram, Radim J, Munnia, Armelle, Rosa, Fabio, Allione, Alessandra, Matullo, Giuseppe, Vineis, Paolo, Ricceri, Fulvio, Godschalk, Roger W, Peluso, Marco, Phillips, David H, Agudo, Antonio, Georgiadis, Panagiotis, Loft, Steffen, Tjønneland, Anne, Raaschou-Nielsen, Ole, Palli, Domenico, Perera, Frederica, Vermeulen, Roel, Taioli, Emanuela, Sram, Radim J, Munnia, Armelle, Rosa, Fabio, Allione, Alessandra, Matullo, Giuseppe, and Vineis, Paolo

Abstract

Bulky DNA adducts are markers of exposure to genotoxic aromatic compounds, which reflect the ability of an individual to metabolically activate carcinogens and to repair DNA damage. Polycyclic aromatic hydrocarbons (PAHs) represent a major class of carcinogens that are capable of forming such adducts. Factors that have been reported to be related to DNA adduct levels include smoking, diet, body mass index (BMI), genetic polymorphisms, the season of collection of biologic material, and air pollutants.

Published
2010

10. Bulky DNA adducts in white blood cells: a pooled analysis of 3,600 subjects

Author

Ricceri, Fulvio, Godschalk, Roger W, Peluso, Marco, Phillips, David H, Agudo, Antonio, Georgiadis, Panagiotis, Loft, Steffen, Tjønneland, Anne, Raaschou-Nielsen, Ole, Palli, Domenico, Perera, Frederica, Vermeulen, Roel, Taioli, Emanuela, Sram, Radim J, Munnia, Armelle, Rosa, Fabio, Allione, Alessandra, Matullo, Giuseppe, Vineis, Paolo, Ricceri, Fulvio, Godschalk, Roger W, Peluso, Marco, Phillips, David H, Agudo, Antonio, Georgiadis, Panagiotis, Loft, Steffen, Tjønneland, Anne, Raaschou-Nielsen, Ole, Palli, Domenico, Perera, Frederica, Vermeulen, Roel, Taioli, Emanuela, Sram, Radim J, Munnia, Armelle, Rosa, Fabio, Allione, Alessandra, Matullo, Giuseppe, and Vineis, Paolo

Abstract

Bulky DNA adducts are markers of exposure to genotoxic aromatic compounds, which reflect the ability of an individual to metabolically activate carcinogens and to repair DNA damage. Polycyclic aromatic hydrocarbons (PAHs) represent a major class of carcinogens that are capable of forming such adducts. Factors that have been reported to be related to DNA adduct levels include smoking, diet, body mass index (BMI), genetic polymorphisms, the season of collection of biologic material, and air pollutants.

Published
2010

11. Bulky DNA adducts, 4-aminobiphenyl-haemoglobin adducts and diet in the European Prospective Investigation into Cancer and Nutrition (EPIC) prospective study.

Author

Peluso, Marco, Airoldi, Luisa, Munnia, Armelle, Colombi, Alessandro, Veglia, Fabrizio, Autrup, Herman, Dunning, Alison, Garte, Seymour, Gormally, Emmanuelle, Malaveille, Christian, Matullo, Giuseppe, Overvad, Kim, Raaschou-Nielsen, Ole, Clavel-Chapelon, Francoise, Linseisen, Jacob, Boeing, Heiner, Trichopoulou, Antonia, Palli, Domenico, Krogh, Vittorio, Tumino, Rosario, Panico, Salvatore, Bueno-De-Mesquita, Bas H, Peeters, Petra H, Kumle, Merethe, Agudo, Antonio, Martinez, Carmen, Dorronsoro, Miren, Barricarte, Aurelio, Tormo, Marìa Jose, Quiros, José Ramón, Berglund, Goran, Jarvholm, Bengt, Day, Nicholas E, Key, Timothy J, Saracci, Rodolfo, Kaaks, Rudolf, Riboli, Elio, Bingham, Shelia, Vineis, Paolo, Peluso, Marco, Airoldi, Luisa, Munnia, Armelle, Colombi, Alessandro, Veglia, Fabrizio, Autrup, Herman, Dunning, Alison, Garte, Seymour, Gormally, Emmanuelle, Malaveille, Christian, Matullo, Giuseppe, Overvad, Kim, Raaschou-Nielsen, Ole, Clavel-Chapelon, Francoise, Linseisen, Jacob, Boeing, Heiner, Trichopoulou, Antonia, Palli, Domenico, Krogh, Vittorio, Tumino, Rosario, Panico, Salvatore, Bueno-De-Mesquita, Bas H, Peeters, Petra H, Kumle, Merethe, Agudo, Antonio, Martinez, Carmen, Dorronsoro, Miren, Barricarte, Aurelio, Tormo, Marìa Jose, Quiros, José Ramón, Berglund, Goran, Jarvholm, Bengt, Day, Nicholas E, Key, Timothy J, Saracci, Rodolfo, Kaaks, Rudolf, Riboli, Elio, Bingham, Shelia, and Vineis, Paolo

Abstract

In contrast to some extensively examined food mutagens, for example, aflatoxins, N-nitrosamines and heterocyclic amines, some other food contaminants, in particular polycyclic aromatic hydrocarbons (PAH) and other aromatic compounds, have received less attention. Therefore, exploring the relationships between dietary habits and the levels of biomarkers related to exposure to aromatic compounds is highly relevant. We have investigated in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort the association between dietary items (food groups and nutrients) and aromatic DNA adducts and 4-aminobiphenyl-Hb adducts. Both types of adducts are biomarkers of carcinogen exposure and possibly of cancer risk, and were measured, respectively, in leucocytes and erythrocytes of 1086 (DNA adducts) and 190 (Hb adducts) non-smokers. An inverse, statistically significant, association has been found between DNA adduct levels and dietary fibre intake (P = 0.02), vitamin E (P = 0.04) and alcohol (P = 0.03) but not with other nutrients or food groups. Also, an inverse association between fibre and fruit intake, and BMI and 4-aminobiphenyl-Hb adducts (P = 0.03, 0.04, and 0.03 respectively) was observed. After multivariate regression analysis these inverse correlations remained statistically significant, except for the correlation adducts v. fruit intake. The present study suggests that fibre intake in the usual range can modify the level of DNA or Hb aromatic adducts, but such role seems to be quantitatively modest. Fibres could reduce the formation of DNA adducts in different manners, by diluting potential food mutagens and carcinogens in the gastrointestinal tract, by speeding their transit through the colon and by binding carcinogenic substances.

Published
2008
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12. DNA adducts and cancer risk in prospective studies: a pooled analysis and a meta-analysis

Author

Veglia, Fabrizio, Loft, Steffen, Matullo, Giuseppe, Peluso, Marco, Munnia, Armelle, Perera, Frederica, Phillips, David H, Tang, Deliang, Autrup, Herman, Raaschou-Nielsen, Ole, Tjønneland, Anne, Vineis, Paolo, Veglia, Fabrizio, Loft, Steffen, Matullo, Giuseppe, Peluso, Marco, Munnia, Armelle, Perera, Frederica, Phillips, David H, Tang, Deliang, Autrup, Herman, Raaschou-Nielsen, Ole, Tjønneland, Anne, and Vineis, Paolo

Abstract

Udgivelsesdato: 2008-May, Bulky DNA adducts are biomarkers of exposure to aromatic compounds and of the ability of the individual to metabolically activate carcinogens and to repair DNA damage. Their ability to predict cancer onset is uncertain. We have performed a pooled analysis of three prospective studies on cancer risk in which bulky DNA adducts have been measured in blood samples collected from healthy subjects (N = 1947; average follow-up 51-137 months). In addition, we have performed a meta-analysis by identifying all articles on the same subject published up to the end of 2006, including case-control studies. In the pooled analysis, a weakly statistically significant increase in the risk of lung cancer was apparent (14% per unit standard deviation change in adduct levels, 95% confidence interval 1-28%; using the weighted mean difference method, 0.15 SD, units higher adducts in cases than in controls). The association was evident only in current smokers and was absent in former smokers. Also the meta-analysis, which included both lung and bladder cancers, showed a statistically significant association in current smokers, whereas the results in never smokers were equivocal; in former smokers, no association was detected. The results of our pooled and meta-analyses suggest that bulky DNA adducts are associated with lung cancer arising in current smokers after a follow-up of several years.

Published
2008

13. DNA adducts and cancer risk in prospective studies: a pooled analysis and a meta-analysis

Author

Veglia, Fabrizio, Loft, Steffen, Matullo, Giuseppe, Peluso, Marco, Munnia, Armelle, Perera, Frederica, Phillips, David H, Tang, Deliang, Autrup, Herman, Raaschou-Nielsen, Ole, Tjønneland, Anne, Vineis, Paolo, Veglia, Fabrizio, Loft, Steffen, Matullo, Giuseppe, Peluso, Marco, Munnia, Armelle, Perera, Frederica, Phillips, David H, Tang, Deliang, Autrup, Herman, Raaschou-Nielsen, Ole, Tjønneland, Anne, and Vineis, Paolo

Abstract

Udgivelsesdato: 2008-May, Bulky DNA adducts are biomarkers of exposure to aromatic compounds and of the ability of the individual to metabolically activate carcinogens and to repair DNA damage. Their ability to predict cancer onset is uncertain. We have performed a pooled analysis of three prospective studies on cancer risk in which bulky DNA adducts have been measured in blood samples collected from healthy subjects (N = 1947; average follow-up 51-137 months). In addition, we have performed a meta-analysis by identifying all articles on the same subject published up to the end of 2006, including case-control studies. In the pooled analysis, a weakly statistically significant increase in the risk of lung cancer was apparent (14% per unit standard deviation change in adduct levels, 95% confidence interval 1-28%; using the weighted mean difference method, 0.15 SD, units higher adducts in cases than in controls). The association was evident only in current smokers and was absent in former smokers. Also the meta-analysis, which included both lung and bladder cancers, showed a statistically significant association in current smokers, whereas the results in never smokers were equivocal; in former smokers, no association was detected. The results of our pooled and meta-analyses suggest that bulky DNA adducts are associated with lung cancer arising in current smokers after a follow-up of several years.

Published
2008

14. TP53 and KRAS2 mutations in plasma DNA of healthy subjects and subsequent cancer occurrence : a prospective study.

Author

Gormally, Emmanuelle, Vineis, Paolo, Matullo, Giuseppe, Veglia, Fabrizio, Caboux, Elodie, Le Roux, Emilie, Peluso, Marco, Garte, Seymour, Guarrera, Simonetta, Munnia, Armelle, Airoldi, Luisa, Autrup, Herman, Malaveille, Christian, Dunning, Alison, Overvad, Kim, Tjønneland, Anne, Lund, Eiliv, Clavel-Chapelon, Françoise, Boeing, Heiner, Trichopoulou, Antonia, Palli, Domenico, Krogh, Vittorio, Tumino, Rosario, Panico, Salvatore, Bueno-de-Mesquita, H Bas, Peeters, Petra H, Pera, Guillem, Martinez, Carmen, Dorronsoro, Miren, Barricarte, Aurelio, Navarro, Carmen, Quirós, José Ramón, Hallmans, Göran, Day, Nicholas E, Key, Timothy J, Saracci, Rodolfo, Kaaks, Rudolf, Riboli, Elio, Hainaut, Pierre, Gormally, Emmanuelle, Vineis, Paolo, Matullo, Giuseppe, Veglia, Fabrizio, Caboux, Elodie, Le Roux, Emilie, Peluso, Marco, Garte, Seymour, Guarrera, Simonetta, Munnia, Armelle, Airoldi, Luisa, Autrup, Herman, Malaveille, Christian, Dunning, Alison, Overvad, Kim, Tjønneland, Anne, Lund, Eiliv, Clavel-Chapelon, Françoise, Boeing, Heiner, Trichopoulou, Antonia, Palli, Domenico, Krogh, Vittorio, Tumino, Rosario, Panico, Salvatore, Bueno-de-Mesquita, H Bas, Peeters, Petra H, Pera, Guillem, Martinez, Carmen, Dorronsoro, Miren, Barricarte, Aurelio, Navarro, Carmen, Quirós, José Ramón, Hallmans, Göran, Day, Nicholas E, Key, Timothy J, Saracci, Rodolfo, Kaaks, Rudolf, Riboli, Elio, and Hainaut, Pierre

Published
2006

15. DNA adducts and lung cancer risk: a prospective study.

Author

Peluso, M., Munnia, A., Hoek, G., Krzyzanowski, M., Veglia, F., Airoldi, L., Autrup, H., Dunning, A., Garte, S., Hainaut, P., Malaveille, C., Gormally, E., Matullo, G., Overvad, K., Raaschou-Nielsen, O., Clavel-Chapelon, F., Linseisen, J., Boeing, H.H., Trichopoulou, A., Trichopoulos, D., Kaladidi, A., Palli, D., Krogh, V., Tumino, R., Panico, S., Bueno de Mesquita, H.B., Peeters, P.H.M., Kumle, M., Gonzalez, C.A., Martinez, C., Dorronsoro, M., Barricarte, A., Navarro, C., Quiros, J.R., Berglund, G., Janzon, L., Jarvholm, B., Day, N.E., Key, T.J., Saracci, R., Kaaks, R., Riboli, E., Vineis, P., Peluso, M., Munnia, A., Hoek, G., Krzyzanowski, M., Veglia, F., Airoldi, L., Autrup, H., Dunning, A., Garte, S., Hainaut, P., Malaveille, C., Gormally, E., Matullo, G., Overvad, K., Raaschou-Nielsen, O., Clavel-Chapelon, F., Linseisen, J., Boeing, H.H., Trichopoulou, A., Trichopoulos, D., Kaladidi, A., Palli, D., Krogh, V., Tumino, R., Panico, S., Bueno de Mesquita, H.B., Peeters, P.H.M., Kumle, M., Gonzalez, C.A., Martinez, C., Dorronsoro, M., Barricarte, A., Navarro, C., Quiros, J.R., Berglund, G., Janzon, L., Jarvholm, B., Day, N.E., Key, T.J., Saracci, R., Kaaks, R., Riboli, E., and Vineis, P.

Published
2005

16. DNA adducts and lung cancer risk : a prospective study.

Author

Peluso, Marco, Munnia, Armelle, Hoek, Gerard, Krzyzanowski, Michal, Veglia, Fabrizio, Airoldi, Luisa, Autrup, Herman, Dunning, Alison, Garte, Seymour, Hainaut, Pierre, Malaveille, Christian, Gormally, Emmanuelle, Matullo, Giuseppe, Overvad, Kim, Raaschou-Nielsen, Ole, Clavel-Chapelon, Francoise, Linseisen, Jacob, Boeing, Heiner, Trichopoulou, Antonia, Trichopoulos, Dimitrios, Kaladidi, Anna, Palli, Domenico, Krogh, Vittorio, Tumino, Rosario, Panico, Salvatore, Bueno-De-Mesquita, H Bas, Peeters, Petra H, Kumle, Merethe, Gonzalez, Carlos A, Martinez, Carmen, Dorronsoro, Miren, Barricarte, Aurelio, Navarro, Carmen, Quiros, J Ramón, Berglund, Goran, Janzon, Lars, Jarvholm, Bengt, Day, Nicholas E, Key, Tim J, Saracci, Rodolfo, Kaaks, Rudolf, Riboli, Elio, Vineis, Paolo, Peluso, Marco, Munnia, Armelle, Hoek, Gerard, Krzyzanowski, Michal, Veglia, Fabrizio, Airoldi, Luisa, Autrup, Herman, Dunning, Alison, Garte, Seymour, Hainaut, Pierre, Malaveille, Christian, Gormally, Emmanuelle, Matullo, Giuseppe, Overvad, Kim, Raaschou-Nielsen, Ole, Clavel-Chapelon, Francoise, Linseisen, Jacob, Boeing, Heiner, Trichopoulou, Antonia, Trichopoulos, Dimitrios, Kaladidi, Anna, Palli, Domenico, Krogh, Vittorio, Tumino, Rosario, Panico, Salvatore, Bueno-De-Mesquita, H Bas, Peeters, Petra H, Kumle, Merethe, Gonzalez, Carlos A, Martinez, Carmen, Dorronsoro, Miren, Barricarte, Aurelio, Navarro, Carmen, Quiros, J Ramón, Berglund, Goran, Janzon, Lars, Jarvholm, Bengt, Day, Nicholas E, Key, Tim J, Saracci, Rodolfo, Kaaks, Rudolf, Riboli, Elio, and Vineis, Paolo

Published
2005

17. DNA adducts and lung cancer risk: a prospective study.

Author

Faculteit Diergeneeskunde, Peluso, M., Munnia, A., Hoek, G., Krzyzanowski, M., Veglia, F., Airoldi, L., Autrup, H., Dunning, A., Garte, S., Hainaut, P., Malaveille, C., Gormally, E., Matullo, G., Overvad, K., Raaschou-Nielsen, O., Clavel-Chapelon, F., Linseisen, J., Boeing, H.H., Trichopoulou, A., Trichopoulos, D., Kaladidi, A., Palli, D., Krogh, V., Tumino, R., Panico, S., Bueno de Mesquita, H.B., Peeters, P.H.M., Kumle, M., Gonzalez, C.A., Martinez, C., Dorronsoro, M., Barricarte, A., Navarro, C., Quiros, J.R., Berglund, G., Janzon, L., Jarvholm, B., Day, N.E., Key, T.J., Saracci, R., Kaaks, R., Riboli, E., Vineis, P., Faculteit Diergeneeskunde, Peluso, M., Munnia, A., Hoek, G., Krzyzanowski, M., Veglia, F., Airoldi, L., Autrup, H., Dunning, A., Garte, S., Hainaut, P., Malaveille, C., Gormally, E., Matullo, G., Overvad, K., Raaschou-Nielsen, O., Clavel-Chapelon, F., Linseisen, J., Boeing, H.H., Trichopoulou, A., Trichopoulos, D., Kaladidi, A., Palli, D., Krogh, V., Tumino, R., Panico, S., Bueno de Mesquita, H.B., Peeters, P.H.M., Kumle, M., Gonzalez, C.A., Martinez, C., Dorronsoro, M., Barricarte, A., Navarro, C., Quiros, J.R., Berglund, G., Janzon, L., Jarvholm, B., Day, N.E., Key, T.J., Saracci, R., Kaaks, R., Riboli, E., and Vineis, P.

Published
2005

18. DNA adducts and lung cancer risk: a prospective study.

Author

Faculteit Diergeneeskunde, Peluso, M., Munnia, A., Hoek, G., Krzyzanowski, M., Veglia, F., Airoldi, L., Autrup, H., Dunning, A., Garte, S., Hainaut, P., Malaveille, C., Gormally, E., Matullo, G., Overvad, K., Raaschou-Nielsen, O., Clavel-Chapelon, F., Linseisen, J., Boeing, H.H., Trichopoulou, A., Trichopoulos, D., Kaladidi, A., Palli, D., Krogh, V., Tumino, R., Panico, S., Bueno de Mesquita, H.B., Peeters, P.H.M., Kumle, M., Gonzalez, C.A., Martinez, C., Dorronsoro, M., Barricarte, A., Navarro, C., Quiros, J.R., Berglund, G., Janzon, L., Jarvholm, B., Day, N.E., Key, T.J., Saracci, R., Kaaks, R., Riboli, E., Vineis, P., Faculteit Diergeneeskunde, Peluso, M., Munnia, A., Hoek, G., Krzyzanowski, M., Veglia, F., Airoldi, L., Autrup, H., Dunning, A., Garte, S., Hainaut, P., Malaveille, C., Gormally, E., Matullo, G., Overvad, K., Raaschou-Nielsen, O., Clavel-Chapelon, F., Linseisen, J., Boeing, H.H., Trichopoulou, A., Trichopoulos, D., Kaladidi, A., Palli, D., Krogh, V., Tumino, R., Panico, S., Bueno de Mesquita, H.B., Peeters, P.H.M., Kumle, M., Gonzalez, C.A., Martinez, C., Dorronsoro, M., Barricarte, A., Navarro, C., Quiros, J.R., Berglund, G., Janzon, L., Jarvholm, B., Day, N.E., Key, T.J., Saracci, R., Kaaks, R., Riboli, E., and Vineis, P.

Published
2005

19. DNA adducts and lung cancer risk: a prospective study.

Author

Faculteit Diergeneeskunde, Peluso, M., Munnia, A., Hoek, G., Krzyzanowski, M., Veglia, F., Airoldi, L., Autrup, H., Dunning, A., Garte, S., Hainaut, P., Malaveille, C., Gormally, E., Matullo, G., Overvad, K., Raaschou-Nielsen, O., Clavel-Chapelon, F., Linseisen, J., Boeing, H.H., Trichopoulou, A., Trichopoulos, D., Kaladidi, A., Palli, D., Krogh, V., Tumino, R., Panico, S., Bueno de Mesquita, H.B., Peeters, P.H.M., Kumle, M., Gonzalez, C.A., Martinez, C., Dorronsoro, M., Barricarte, A., Navarro, C., Quiros, J.R., Berglund, G., Janzon, L., Jarvholm, B., Day, N.E., Key, T.J., Saracci, R., Kaaks, R., Riboli, E., Vineis, P., Faculteit Diergeneeskunde, Peluso, M., Munnia, A., Hoek, G., Krzyzanowski, M., Veglia, F., Airoldi, L., Autrup, H., Dunning, A., Garte, S., Hainaut, P., Malaveille, C., Gormally, E., Matullo, G., Overvad, K., Raaschou-Nielsen, O., Clavel-Chapelon, F., Linseisen, J., Boeing, H.H., Trichopoulou, A., Trichopoulos, D., Kaladidi, A., Palli, D., Krogh, V., Tumino, R., Panico, S., Bueno de Mesquita, H.B., Peeters, P.H.M., Kumle, M., Gonzalez, C.A., Martinez, C., Dorronsoro, M., Barricarte, A., Navarro, C., Quiros, J.R., Berglund, G., Janzon, L., Jarvholm, B., Day, N.E., Key, T.J., Saracci, R., Kaaks, R., Riboli, E., and Vineis, P.

Published
2005

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