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Enhancing smallholder chicken production and productivity is an integral component of agricultural development strategies in sub-Saharan Africa. The African Chicken Genetic Gain (ACGG) project has been testing, identifying, and disseminating tropically adapted improved breeds (TAIBs) in Africa to improve the production and productivity of the sector. We applied a multimethod approach and integrated analysis to explore the overall feasibility of TAIBs under smallholder management conditions and documented evidence for sustained adoption. We used data from a baseline survey, on-farm experiment, cluster-randomized study, and market assessment survey to analyse the technical, economic, social, and environmental feasibility of TAIBs adoption under smallholder management conditions. The multimethod approach attests TAIBs as a sustainable technological alternative to smallholder chicken producers in the region. Most smallholder farmers prefer TAIBs to indigenous breeds, and TAIBs-based production enhance producers’ consumption and income generation goals. Moreover, adopting these breeds generates higher economic gains, is socially viable, is technically feasible, and has mitigable environmental risks. However, sustained adoption requires delivery models, capacity building, marketing and financial models, and integrated risks reduction strategies. We argue that demonstrating innovations’ economic, social, technical, and ecological viability and enhancing access to efficient input and output markets are vital for sustained agricultural technology adoption.

Increasing poultry product consumption trends have attracted researchers and development practitioners to look for interventions that transform the low-input low-output-based village chicken production to a high yielding production system. However, due to the intricate nature of the production system, there is a dearth of evidence that helps design comprehensive interventions at the smallholder level. Using national-level representative data collected from 3555 village chicken producers in Ethiopia, Nigeria, and Tanzania, this study examines the technical efficiency of village chicken production and investigates the main factors that explain the level of inefficiency. We applied a stochastic frontier analysis to simultaneously quantify the level of technical efficiency and identify factors associated with heterogeneity in inefficiency. We found that the level of technical efficiency is extremely low in the three countries, suggesting enormous opportunities to enhance productivity using available resources. The heterogeneity in technical efficiency is strongly associated with producers’ experience in breed improvements and flock management, limited technical knowledge and skills, limited access to institutions and markets, smaller flock size, gender dispari-ties, and household livelihood orientation. We argue the need to adopt an integrated approach to enhance village producers’ productivity and transform the traditional subsistence-based production system into a commercially oriented semi-intensive production system.

Drug dosing in neonates should be based on integrated knowledge concerning the disease to be treated, the physiological characteristics of the neonate, and the pharmacokinetics (PK) and pharmacodynamics (PD) of a given drug. It is critically important that all sources of information be leveraged to optimize dose selection for neonates. Sources may include data from adult studies, pediatric studies, non-clinical (juvenile) animal models, in vitro studies, and in silico models. Depending on the drug development program, each of these modalities could be used to varying degrees and with varying levels of confidence to guide dosing. This paper aims to illustrate the variability between neonatal drug development programs for neonatal diseases that are similar to those seen in other populations (meropenem), neonatal diseases related but not similar to pediatric or adult populations (clopidogrel, thyroid hormone), and diseases unique to neonates (caffeine, surfactant). Extrapolation of efficacy from older children or adults to neonates is infrequently used. Even if a disease process is similar between neonates and children or adults, such as with anti-infectives, additional dosing and safety information will be necessary for labeling, recognizing that dosing in neonates is confounded by maturational PK in addition to body size.

The issues of measurement of technical efficiency in the production of matoke in Uganda are investigated. A Cobb-Douglas functional form is used to represent the underlying production technology and corrected least squares procedure to estimate the model and the farm-specific measures of technical efficiency. The data consists of a crossection of 288 matoke-producing family farms during the crop year 1990-1991. The productive performance of farms are compared according to the size of land. The impact of various production characteristics on the production structure of the farms is also tested. The empirical results from a comparison of different farm sizes show very small variations in mean efficiency between the different size classes. Some variations in the distribution of farms within each size-class are observed. The mean technical efficiency is found to be 65%.