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Footprints represent a relevant vestige providing direct information on the biology, locomotion, and behaviour of the individuals who left them. However, the spatiotemporal distribution of hominin footprints is heterogeneous, particularly in North Africa, where no footprint sites were known before the Holocene. This region is important in the evolution of hominins. It notably includes the earliest currently known Homo sapiens (Jebel Irhoud) and the oldest and richest African Middle Stone Age hominin sites. In this fragmented ichnological record, we report the discovery of 85 human footprints on a Late Pleistocene now indurated beach surface of about 2800 m2 at Larache (Northwest coast of Morocco). The wide range of sizes of the footprints suggests that several individuals from different age groups made the tracks while moving landward and seaward across a semi-dissipative bar-trough sandy beach foreshore. A geological investigation and an optically stimulated luminescence dating of a rock sample extracted from the tracksite places this hominin footprint surface at 90.3 ± 7.6 ka (MIS 5, Late Pleistocene). The Larache footprints are, therefore, the oldest attributed to Homo sapiens in Northern Africa and the Southern Mediterranean.

This research is part of the TSEAS-EUCO Service Learning (ApS) project implemented by the San José-Jesuitas Schools in Valencia. Its main objective is to address the "uncertainty" of TSEAS students towards SEN students, in order to promote inclusion and equal opportunities in education through Physical Education, helping students with disabilities to break down social and cultural barriers that limit their participation in society. During two school years, the inclusive practices designed and curricularly adapted by students in the 2nd year of the TSEAS training cycle to UECO students have been analysed through participant observation, carrying out an initial and a final evaluation-diagnosis, as well as a field observation and interviews with the participating TSEAS students. The results show a curricular progress of UECO students through Physical Education and sports practice, which have improved the social interactions and communication of all students, as well as a very significant progress of TSEAS students. Through this research it has been empirically proven that education and health through Physical Education are key to social inclusion for students with disabilities, as they generate greater equality of opportunities by providing healthy habits, preventing illnesses and improving people's quality of life., Esta investigación parte del proyecto Aprendizaje de Servicio (ApS) TSEAS-UECO puesto en marcha por las Escuelas San José-Jesuitas de Valencia. Su objetivo principal pretende abordar la “incertidumbre” del alumnado TSEAS hacia el alumnado NEE, para fomentar la inclusión y la igualdad de oportunidades en el ámbito educativo a través de la Educación Física, ayudando al alumnado con discapacidad a romper barreras sociales y culturales que limitan su participación en la sociedad. Durante dos cursos escolares se han analizado a través de la observación participante las prácticas inclusivas diseñadas y adaptadas curricularmente por alumnado de 2º curso del ciclo formativo de TSEAS a alumnado UECO, realizándose una evaluación-diagnóstico inicial y otra final, así como una observación de campo y entrevistas al alumnado TSEAS participante. Los resultados señalan un progreso curricular del alumnado UECO a través de la Educación Física y la práctica deportiva, que han mejorado las interacciones sociales y la comunicación de todo el alumnado, así como un avance muy significativo del alumnado TSEAS. A través de esta investigación se ha podido comprobar empíricamente que la educación y la salud a través de la Educación Física son claves en la inclusión social para el alumnado con discapacidad, ya que generan una mayor igualdad de oportunidades al proporcionar hábitos saludables, prevenir enfermedades y mejorar la calidad de vida de las personas.

Parkinson’s disease (PD) is a complex disorder characterized by the impairment of the dopaminergic nigrostriatal system. PD has duplicated its global burden in the last few years, becoming the leading neurological disability worldwide. Therefore, there is an urgent need to develop innovative approaches that target multifactorial underlying causes to potentially prevent or limit disease progression. Accumulating evidence suggests that neuroinflammatory responses may play a pivotal role in the neurodegenerative processes that occur during the development of PD. Cortistatin is a neuropeptide that has shown potent anti-inflammatory and immunoregulatory effects in preclinical models of autoimmune and neuroinflammatory disorders. The goal of this study was to explore the therapeutic potential of cortistatin in a well-established preclinical mouse model of PD induced by acute exposure to the neurotoxin 1-methil-4-phenyl1-1,2,3,6-tetrahydropyridine (MPTP). We observed that treatment with cortistatin mitigated the MPTP-induced loss of dopaminergic neurons in the substantia nigra and their connections to the striatum. Consequently, cortistatin administration improved the locomotor activity of animals intoxicated with MPTP. In addition, cortistatin diminished the presence and activation of glial cells in the affected brain regions of MPTP-treated mice, reduced the production of immune mediators, and promoted the expression of neurotrophic factors in the striatum. In an in vitro model of PD, treatment with cortistatin also demonstrated a reduction in the cell death of dopaminergic neurons that were exposed to the neurotoxin. Taken together, these findings suggest that cortistatin could emerge as a promising new therapeutic agent that combines anti-inflammatory and neuroprotective properties to regulate the progression of PD at multiple levels.

El Grupo de Paleoantropología del Museo Nacional de Ciencias Naturales {CSIC), que lidera un equipo de investigadores españoles y ecuatoguineanos, lleva desde 2014 realizando campañas arqueo-paleontológicas en Guinea Ecuatorial con el objetivo de localizar pruebas del primer poblamiento humano en las pluvisilvas de África Central, habiéndose documentado las evidencias más antiguas de presencia humana en esa parte del planeta.

Nitric oxide (NO) is a gasotransmitter required in a broad range of mechanisms controlling plant development and stress conditions. However, little is known about the specific role of this signaling molecule during lipid storage in the seeds. Here, we show that NO is accumulated in developing embryos and regulates the fatty acid profile through the stabilization of the basic/leucine zipper transcription factor bZIP67. NO and nitro-linolenic acid target and accumulate bZIP67 to induce the downstream expression of FAD3 desaturase, which is misregulated in a non-nitrosylable version of the protein. Moreover, the post-translational modification of bZIP67 is reversible by the trans-denitrosylation activity of peroxiredoxin IIE and defines a feedback mechanism for bZIP67 redox regulation. These findings provide a molecular framework to control the seed fatty acid profile caused by NO, and evidence of the in vivo functionality of nitro-fatty acids during plant developmental signaling.

Retinitis pigmentosa is a common cause of inherited blindness in adults, which in many cases is associated with an increase in the formation of reactive oxygen species (ROS) that induces DNA damage, triggering Poly-ADP-Ribose Polymerase 1 (PARP1) activation and leading to parthanatos-mediated cell death. Previous studies have shown that resveratrol (RSV) is a promising molecule that can mitigate PARP1 overactivity, but its low bioavailability is a limitation for medical use. This study examined the impact of a synthesized new acylated RSV prodrug, piceid octanoate (PIC-OCT), in the 661W cell line against H2O2 oxidative stress and in rd10 mice. PIC-OCT possesses a better ADME profile than RSV. In response to H2O2, 661W cells pretreated with PIC-OCT preserved cell viability in more than 38% of cells by significantly promoting SIRT1 nuclear translocation, preserving NAD+/NADH ratio, and suppressing intracellular ROS formation. These effects result from expressing antioxidant genes, maintaining mitochondrial function, reducing PARP1 nuclear expression, and preventing AIF nuclear translocation. In rd10 mice, PIC-OCT inhibited PAR-polymer formation, increased SIRT1 expression, significantly reduced TUNEL-positive cells in the retinal outer nuclear layer, preserved ERGs, and enhanced light chamber activity (all p values < 0.05). Our findings corroborate that PIC-OCT protects photoreceptors by modulating the SIRT1/PARP1 axis in models of retinal degeneration.

Abridged: We measured photometric and spectroscopic $P_{\rm rot}$ for a large sample of nearby bright M dwarfs with spectral types from M0 to M9, as part of our continual effort to fully characterize the Guaranteed Time Observation programme stars of the CARMENES survey. We determine $P_{\rm rot}$ for 129 stars. Combined with the literature, we tabulate $P_{\rm rot}$ for 261 stars, or 75% of our sample. We evaluate the plausibility of all periods available for this sample by comparing them with activity signatures and checking for consistency between multiple measurements. We find that 166 of these stars have independent evidence that confirmed their $P_{\rm rot}$. There are inconsistencies in 27 periods, which we classify as debated. A further 68 periods are identified as provisional detections that could benefit from independent verification. We provide an empirical relation for the $P_{\rm rot}$ uncertainty as a function of the $P_{\rm rot}$ value, based on the dispersion of the measurements. We show that published formal errors seem to be often underestimated for periods $\gtrsim 10$ d. We highlight the importance of independent verification on $P_{\rm rot}$ measurements, especially for inactive M dwarfs. We examine rotation-activity relations with emission in X-rays, H$\alpha$, Ca II H & K, and surface magnetic field strengths. We find overall agreement with previous works, as well as tentative differences in the partially versus fully convective subsamples. We show $P_{\rm rot}$ as a function of stellar mass, age, and galactic kinematics. With the notable exception of three transiting planet systems and TZ Ari, all known planet hosts in this sample have $P_{\rm rot} \gtrsim 15$ d. This indicates that important limitations need to be overcome before the radial velocity technique can be routinely used to detect and study planets around young and active stars., Comment: Accepted for publication in A&A

Prostate cancer is the second most frequent cancer in men worldwide after lung cancer. Its diagnosis is based on the identification of the Gleason score that evaluates the abnormality of cells in glands through the analysis of the different Gleason patterns within tissue samples. The recent advancements in computational pathology, a domain aiming at developing algorithms to automatically analyze digitized histopathology images, lead to a large variety and availability of datasets and algorithms for Gleason grading and scoring. However, there is no clear consensus on which methods are best suited for each problem in relation to the characteristics of data and labels. This paper provides a systematic comparison on nine datasets with state-of-the-art training approaches for deep neural networks (including fully-supervised learning, weakly-supervised learning, semi-supervised learning, Additive-MIL, Attention-Based MIL, Dual-Stream MIL, TransMIL and CLAM) applied to Gleason grading and scoring tasks. The nine datasets are collected from pathology institutes and openly accessible repositories. The results show that the best methods for Gleason grading and Gleason scoring tasks are fully supervised learning and CLAM, respectively, guiding researchers to the best practice to adopt depending on the task to solve and the labels that are available.

For some years now, the locomotion mechanisms used by vertebrate animals have been a major inspiration for the improvement of robotic systems. These mechanisms range from adapting their movements to move through the environment to the ability to chase prey, all thanks to senses such as sight, hearing, and touch. Neuromorphic engineering is inspired by brain problem-solving techniques with the goal of implementing models that take advantage of the characteristics of biological neural systems. While this is a well-defined and explored area in this field, there is no previous work that fuses analog and neuromorphic sensors to control and modify robotic behavior in real time. Herein, a system is presented based on spiking neural networks implemented on the SpiNNaker hardware platform that receives information from both analog (force-sensing resistor) and digital (neuromorphic retina) sensors and is able to adapt the speed and orientation of a hexapod robot depending on the stability of the terrain where it is located and the position of the target. These sensors are used to modify the behavior of different spiking central pattern generators, which in turn will adapt the speed and orientation of the robotic platform, all in real time. In particular, experiments show that the network is capable of correctly adapting to the stimuli received from the sensors, modifying the speed and heading of the robotic platform.

Este documento esboza una propuesta de un parque biblioteca en Medellín, Colombia, con el objetivo global de lograr una transformación social construyendo nuevos puntos de referencia para la integración de la comunidad logrando un sentido de identidad y de pertenencia, conectando los espacios interiores y exteriores. El proyecto explora y se basa en los principios de la flexibilidad arquitectónica, garantizando que el espacio pueda adaptarse a las necesidades cambiantes de sus usuarios. La flexibilidad emerge como una solución prometedora para abordar los desafíos que enfrentan las bibliotecas en la actualidad. Al adoptar un enfoque más flexible en el diseño y la operación de las bibliotecas, estas instituciones pueden mantener su relevancia y utilidad en un mundo en constante cambio, sirviendo como centros dinámicos de aprendizaje, colaboración y comunidad.

Este documento esboza una propuesta de un parque biblioteca en Medellín, Colombia, con el objetivo global de lograr una transformación social construyendo nuevos puntos de referencia para la integración de la comunidad logrando un sentido de identidad y de pertenencia, conectando los espacios interiores y exteriores. El proyecto explora y se basa en los principios de la flexibilidad arquitectónica, garantizando que el espacio pueda adaptarse a las necesidades cambiantes de sus usuarios. La flexibilidad emerge como una solución prometedora para abordar los desafíos que enfrentan las bibliotecas en la actualidad. Al adoptar un enfoque más flexible en el diseño y la operación de las bibliotecas, estas instituciones pueden mantener su relevancia y utilidad en un mundo en constante cambio, sirviendo como centros dinámicos de aprendizaje, colaboración y comunidad.

Computational pathology targets the automatic analysis of Whole Slide Images (WSI). WSIs are high-resolution digitized histopathology images, stained with chemical reagents to highlight specific tissue structures and scanned via whole slide scanners. The application of different parameters during WSI acquisition may lead to stain color heterogeneity, especially considering samples collected from several medical centers. Dealing with stain color heterogeneity often limits the robustness of methods developed to analyze WSIs, in particular Convolutional Neural Networks (CNN), the state-of-the-art algorithm for most computational pathology tasks. Stain color heterogeneity is still an unsolved problem, although several methods have been developed to alleviate it, such as Hue-Saturation-Contrast (HSC) color augmentation and stain augmentation methods. The goal of this paper is to present Data-Driven Color Augmentation (DDCA), a method to improve the efficiency of color augmentation methods by increasing the reliability of the samples used for training computational pathology models. During CNN training, a database including over 2 million H&E color variations collected from private and public datasets is used as a reference to discard augmented data with color distributions that do not correspond to realistic data. DDCA is applied to HSC color augmentation, stain augmentation and H&E-adversarial networks in colon and prostate cancer classification tasks. DDCA is then compared with 11 state-of-the-art baseline methods to handle color heterogeneity, showing that it can substantially improve classification performance on unseen data including heterogeneous color variations.

New methodological approaches focused on studying the reduction and use-life of stone tools have emerged in recent years, enabling researchers to move beyond strict technical and technological characterizations and explore specific aspects of occupation dynamics and economic management of resources. Previous studies have shown the importance of reduction distributions of individual measurements rather than averaged values. In this sense, survival analysis, and more specifically Weibull distributions, are one of the main inferential tools used in reduction studies. However, the resolution of Weibull distribution obtained from different methods has not been tested experimentally. In this paper, we present an evaluation of some of the main methods used in the study of core reduction intensity, such as the Volumetric Reconstruction Method, the Scar Density Index, and the non-cortical surface percentage. Our results show 1) strong and positive correlations between these approaches and actual reduction intensity, 2) similar Weibull distributions for non-cortical surface percentage, Volumetric Reconstruction Method, and logarithmic transformation of Scar Density Index. In addition, 3) the results from each method show a similar intra-assemblage variation, with a high percentage of agreement between them. As a result, all the evaluated proposals are useful and reliable methods for estimating the degree of reduction. Finally, a workflow is proposed for approaching reduction in archaeological assemblages by integrating different methods in the same study.

Bakgrund: Demenssjukdom förväntas öka i framtiden vilket kan komma att påverkaröntgenkliniker samt avdelningar som möter patientkategorin. Det finns svårigheter att undersöka patienter med demenssjukdom på grund av beteendeförändringar, agitation samt röntgensjuksköterskans korta möte. Det är därför av vikt att sammanställa den forskning som finns inom ämnet idag. Syfte: Att beskriva röntgensjuksköterskors, röntgensjuksköterskestudenters samt sjuksköterskors erfarenheter av att vårda patienter med demenssjukdom. Metod:En litteraturstudie vars resultat är uppbyggt på åtta kvalitativa studier. Databaserna som användes vid artikelsökning var Cinahl, Pubmed och Scopus. Analysen har varit inspirerad av Fribergs metod. Resultat:Tre huvudkategorier och nio underkategorier skapades efter analys av samtliga studier. Huvudkategorierna omfattar: Uppfatta orsaker till olämplig vård för personer med demenssjukdom, erfara svåra utmaningar vid behandling av patienter med demenssjukdom och uppleva faktorer som påverkar personcentrerad vård av patienter med demenssjukdom. Konklusion:Det korta vårdmötet begränsar möjligheten för vårdare att ge patienter med demenssjukdom god vård, vilket indikerar behovet av att avsätta mer tid till patienter med demenssjukdom. Kunskapsbrist har visats vara ett återkommande problem vid vård av demenssjukdom och ökad utbildning kan vara en adekvat åtgärd. Nyckelord: Radiografi, personcentrerad vård, beteendemässiga utmaningar, individuell erfarenhet, Background: Dementia will increase in the future which can affect radiology clinics and hospital departments caring for patients with dementia. There are difficulties examining patients with dementia due to behavioral changes, agitation and the limited time radiology nurses spend with patients. Therefore it is important to summarize current research on the subject. Aim: Describe the experiences of diagnostic radiology nurses, students in radiology nursing programs and general nurses when caring for patients with dementia Method:A literature review of eight qualitative studies using Cinahl, Pubmed and Scopus databases to discover articles. The analysis was inspired by Friberg’s method. Results:Three main categories and nine subcategories were identified after analysis. The main categories were; caregiver perceived reasons for inappropriate care of patients with dementia, difficult challenges experienced while treating patients with dementia, and perceived elements that affect personalized patient-centered care for those with dementia. Conclusion:The limited time allocated to attend to patients, limits the ability of caregivers to provide good care. This indicates a need to devote additional time for patients with dementia. A lack of knowledge was identified in dementia care, where increased education can be an adequate measure. Keywords: Radiography, patient-centred care, behavioural challenges encountered, individual experiences

Bakgrund: Demenssjukdom förväntas öka i framtiden vilket kan komma att påverkaröntgenkliniker samt avdelningar som möter patientkategorin. Det finns svårigheter att undersöka patienter med demenssjukdom på grund av beteendeförändringar, agitation samt röntgensjuksköterskans korta möte. Det är därför av vikt att sammanställa den forskning som finns inom ämnet idag. Syfte: Att beskriva röntgensjuksköterskors, röntgensjuksköterskestudenters samt sjuksköterskors erfarenheter av att vårda patienter med demenssjukdom. Metod:En litteraturstudie vars resultat är uppbyggt på åtta kvalitativa studier. Databaserna som användes vid artikelsökning var Cinahl, Pubmed och Scopus. Analysen har varit inspirerad av Fribergs metod. Resultat:Tre huvudkategorier och nio underkategorier skapades efter analys av samtliga studier. Huvudkategorierna omfattar: Uppfatta orsaker till olämplig vård för personer med demenssjukdom, erfara svåra utmaningar vid behandling av patienter med demenssjukdom och uppleva faktorer som påverkar personcentrerad vård av patienter med demenssjukdom. Konklusion:Det korta vårdmötet begränsar möjligheten för vårdare att ge patienter med demenssjukdom god vård, vilket indikerar behovet av att avsätta mer tid till patienter med demenssjukdom. Kunskapsbrist har visats vara ett återkommande problem vid vård av demenssjukdom och ökad utbildning kan vara en adekvat åtgärd. Nyckelord: Radiografi, personcentrerad vård, beteendemässiga utmaningar, individuell erfarenhet, Background: Dementia will increase in the future which can affect radiology clinics and hospital departments caring for patients with dementia. There are difficulties examining patients with dementia due to behavioral changes, agitation and the limited time radiology nurses spend with patients. Therefore it is important to summarize current research on the subject. Aim: Describe the experiences of diagnostic radiology nurses, students in radiology nursing programs and general nurses when caring for patients with dementia Method:A literature review of eight qualitative studies using Cinahl, Pubmed and Scopus databases to discover articles. The analysis was inspired by Friberg’s method. Results:Three main categories and nine subcategories were identified after analysis. The main categories were; caregiver perceived reasons for inappropriate care of patients with dementia, difficult challenges experienced while treating patients with dementia, and perceived elements that affect personalized patient-centered care for those with dementia. Conclusion:The limited time allocated to attend to patients, limits the ability of caregivers to provide good care. This indicates a need to devote additional time for patients with dementia. A lack of knowledge was identified in dementia care, where increased education can be an adequate measure. Keywords: Radiography, patient-centred care, behavioural challenges encountered, individual experiences

Computational pathology targets the automatic analysis of Whole Slide Images (WSI). WSIs are high-resolution digitized histopathology images, stained with chemical reagents to highlight specific tissue structures and scanned via whole slide scanners. The application of different parameters during WSI acquisition may lead to stain color heterogeneity, especially considering samples collected from several medical centers. Dealing with stain color heterogeneity often limits the robustness of methods developed to analyze WSIs, in particular Convolutional Neural Networks (CNN), the state-of-the-art algorithm for most computational pathology tasks. Stain color heterogeneity is still an unsolved problem, although several methods have been developed to alleviate it, such as Hue-Saturation-Contrast (HSC) color augmentation and stain augmentation methods. The goal of this paper is to present Data-Driven Color Augmentation (DDCA), a method to improve the efficiency of color augmentation methods by increasing the reliability of the samples used for training computational pathology models. During CNN training, a database including over 2 million H&E color variations collected from private and public datasets is used as a reference to discard augmented data with color distributions that do not correspond to realistic data. DDCA is applied to HSC color augmentation, stain augmentation and H&E-adversarial networks in colon and prostate cancer classification tasks. DDCA is then compared with 11 state-of-the-art baseline methods to handle color heterogeneity, showing that it can substantially improve classification performance on unseen data including heterogeneous color variations.

Most processing of the human diet occurs in the small intestine. Metabolites in the small intestine originate from host secretions, plus the ingested exposome1 and microbial transformations. Here we probe the spatiotemporal variation of upper intestinal luminal contents during routine daily digestion in 15 healthy male and female participants. For this, we use a non-invasive, ingestible sampling device to collect and analyse 274 intestinal samples and 60 corresponding stool homogenates by combining five mass spectrometry assays2,3 and 16S rRNA sequencing. We identify 1,909 metabolites, including sulfonolipids and fatty acid esters of hydroxy fatty acids (FAHFA) lipids. We observe that stool and intestinal metabolomes differ dramatically. Food metabolites display trends in dietary biomarkers, unexpected increases in dicarboxylic acids along the intestinal tract and a positive association between luminal keto acids and fruit intake. Diet-derived and microbially linked metabolites account for the largest inter-individual differences. Notably, two individuals who had taken antibiotics within 6 months before sampling show large variation in levels of bioactive FAHFAs and sulfonolipids and other microbially related metabolites. From inter-individual variation, we identify Blautia species as a candidate to be involved in FAHFA metabolism. In conclusion, non-invasive, in vivo sampling of the human small intestine and ascending colon under physiological conditions reveals links between diet, host and microbial metabolism.

Introduction: Endocannabinoids are a target in obesity treatment and they are produced from the essential fatty acids, the metabolites of linoleic acid act as agonists of the cannabinoid receptors type 1 (CB1), likewise, the metabolites of the linolenic acid act as inverse agonists of such receptors, hence, it is proposed that modifying the dietary intake of the essential fatty acids (Omega 6 and 3) may modulate the activation of the endocannabinoid system, this could be favorable for people with food addiction, considering how this system promotes the activity of the dopaminergic pathways that are altered in the psychoactive substances addiction. Objective: To analyze the correlation between the food addiction score and plasmatic levels of arachidonic acid in adults with obesity following a modulation of the dietary intake of essential fatty acids n-6 and n-3 food sources. Methods: A pilot study was carried out with a two-period crossover clinical trial design, in which the participants received standard and experimental treatments, in these programs, plans were provided following guidelines for the nutritional management of obesity, in addition, the experimental treatment included recommendations to reduce the intake of linoleic acid and to increase the intake of linolenic acid to obtain a ratio lower to 5:1 between these fatty acids. Results: A significant decrease in the food addiction score and plasmatic levels of arachidonic acid was observed in the participants exposed to the experimental treatment, showing a directly proportional correlation, moreover, the standard treatment was associated to inverse correlations between these variables. Conclusion: The decrease in plasmatic arachidonic acid levels was associated with lower scores on the mYFAS 2.0 of food addiction in the participants of this study following their exposure to the experimental treatment, Introducción: los endocannabinoides son una diana en el tratamiento de la obesidad y se producen a partir de ácidos grasos esenciales, los derivados del ácido linoleico actúan como agonistas de los receptores cannabinoides tipo 1 (CB1), asimismo, los derivados del ácido linolénico ejercen efectos de antagonistas de dichos receptores, por lo cual se plantea que modificar el consumo dietario de los ácidos grasos omega 3 y 6 podría modular la activación del sistema endocannabinoide, lo que podría ser favorable para personas con adicción a la comida, considerando cómo este sistema promueve la actividad de las vías dopaminérgicas que se alteran en la adicción a sustancias psicoactivas. Objetivo: analizar la correlación entre el puntaje de adicción a la comida por la escala mYFAS 2.0 y los niveles plasmáticos de ácido araquidónico en adultos con obesidad tras modular la ingesta de alimentos fuente de ácidos grasos esenciales. Metodología: se desarrolló un estudio piloto con diseño de ensayo clínico cruzado en dos tiempos, en donde los participantes recibieron los tratamientos estándar y experimental, en estos se brindaron planes siguiendo recomendaciones para el manejo nutricional de la obesidad, adicionalmente, el tratamiento experimental contó con pautas para disminuir el consumo del Omega 6 y aumentar el consumo de Omega 3 para obtener una relación menor a 5:1 entre estos ácidos grasos. Resultados: se observó una disminución significativa en el puntaje de adicción a la comida y los niveles plasmáticos de ácido araquidónico en los participantes tras recibir el tratamiento experimental, presentando una correlación directamente proporcional entre estas, por otro lado, el tratamiento estándar estuvo asociado a una correlación inversamente proporcional entre estos. Conclusiones: el descenso en las concentraciones plasmáticas del ácido araquidónico fue asociado a un menor puntaje en la escala mYFAS 2.0 de adicción a la comida en los participantes de este estudio tras su expo

Introduction. Hyperglycemia and hyperlipidemia contribute to the endogenous formation of advanced glycation end products (AGEs), and diet constitutes one of the exogenous sources. The binding of AGEs to receptor for glycation end products (RAGE) induces signaling pathways that activate the transcription of inflammatory and oxidative stress markers. Soluble RAGE (sRAGE) levels have been proposed as a biomarker in inflammatory diseases. Several studies describe the role of RAGE in obesity, so it has been discussed whether there is a differential pattern between children with normal weight and obesity. Several studies describe the role of RAGE in obesity, so it has been discussed whether there is a differential pattern between children with normal weight and obesity. Aim. Describe the relationship between RAGE, its isoforms, ligands, biological functions, and comorbidities related to childhood obesity. To determine if decreased sRAGE levels represent a biomarker of childhood obesity based on the results of clinical, observational, and cross-sectional studies. Methodology. Descriptive review of studies published in the period from 2016 to 2022 in the PubMed and Google Scholar databases using the terms “AGEs”, “RAGE”, “sRAGE”, “childhood obesity”. Results and conclusion. A total of 141 articles related to the keywords were consulted. The elimination criteria consisted of references published before 2015, except for classic references. 63 articles from 2016 to 2022 were reviewed, six represent cross-sectional studies on sRAGE levels in the pediatric population, finding differences in the expression of RAGE according to nutritional status, Introducción. La hiperglucemia e hiperlipidemia contribuyen a la formación endógena de productos finales de glicación avanzada (AGEs), y la dieta constituye parte de las fuentes exógenas. La unión de AGEs al receptor de los productos finales de glicación (RAGE), induce vías de señalización que culminan en la activación de factores de transcripción que promueven la expresión de marcadores inflamatorios y de estrés oxidativo. Los niveles de RAGE soluble (sRAGE) han sido propuestos como biomarcador en enfermedades que cursan con un proceso inflamatorio. Diversos estudios describen el papel de RAGE en la obesidad, por lo que se ha discutido si existe un patrón diferencial entre niños con normo peso y obesidad. Objetivo. Describir la relación entre RAGE, sus isoformas, ligandos, funciones biológicas, y las comorbilidades relacionadas con la obesidad infantil. Determinar si los niveles disminuidos de sRAGE representan un biomarcador de la obesidad infantil con base en los resultados de estudios clínicos, observacionales y transversales. Metodología. Revisión descriptiva de estudios publicados en el periodo del año 2016 al 2022 en las bases de datos PubMed y Google Académico empleando los términos “AGEs”, “RAGE”, “sRAGE”, y “obesidad infantil”. Resultados y conclusiones. Fueron consultados un total de 141 artículos relacionados con las palabras clave. El criterio de eliminación consistió en referencias publicadas antes del 2015, con excepción de las referencias clásicas. Se revisaron 63 artículos de 2016 a 2022, 6 representan estudios transversales sobre los niveles de sRAGE en población pediátrica, encontrando diferencias en la expresión de RAGE de acuerdo con el estado nutricional.

La exitosa realización del “III Congreso Internacional de Ética en Cuenca, Ciudad Universitaria”, los días 23, 24 y 25 de noviembre del año dos mil veinte y dos, bajo la responsabilidad de la Universidad Católica de Cuenca y en el marco institucional de la Red Universitaria y Ciudadana de Ética y Bioética, RUCEB, de la cual esta distinguida institución forma parte junto a la Universidad del Azuay, Universidad de Cuenca y Universidad Politécnica Salesiana, fue el momento propicio para que el ya sostenido trabajo reflexivo sobre la ética en diferentes ámbitos del quehacer social sea presentado por estudiantes y profesores, locales, nacionales y extranjeros.

El objetivo de este trabajo fue estudiar la relación entre la matutinidad-vespertinidad y la ansiedad rasgo en adolescentes. La muestra estaba formada por 638 adolescentes de 12 a 14 años. Se midió la matutinidadvespertinidad mediante la Escala de Matutinidad-Vespertinidad para Niños, MESC (Carskadon, Vieira y Acebo, 1993) y la ansiedad rasgo mediante el Inventario de Ansiedad Estado-Rasgo para niños, STAIC (Spielberger, Edwards, Lushene, Montuori y Platzek, 1973; Spielberger, Edwards y Lushene, 1990). Los resultados indicaron que las chicas eran más vespertinas, que la vespertinidad aumentaba con la edad y una relación negativa entre matutinidad y ansiedad rasgo. Aquellos adolescentes más vespertinos obtuvieron una mayor ansiedad rasgo, posiblemente debido a un mayor desajusteentre los ritmos biológicos y sociales (horarios escolares matutinos, The relationship between morningness-eveningness and anxiety trait among adolescents was studied. Six hundred thirty eight adolescents between 12 and 14 years old participated in this study. Morningness-eveningness was measured by the Morningness-Eveningness Scale for Children, MESC (Carskadon, Vieira & Acebo, 1993) and anxiety trait was measured by the State-Trait Anxiety Inventory for Children, STAIC (Spielberger, Edwards, Lushene, Montuori & Platzek, 1973; Spielberger, Edwards & Lushene, 1990). Results showed higher eveningness among girls, eveningness increased with age and anxiety trait was higher as morningness diminished. Therefore, evening-oriented adolescents claimed higher anxiety trait, which was waited since they would have a greater misalignment between both biological and social rhythms (school morning schedules)., Ministerio de Ciencia e Innovación (MICINN), Depto. de Psicología Social, del Trabajo y Diferencial, Fac. de Psicología, TRUE, pub

Adolescents in high school suffer from circadian misalignment, undersleeping on weekdays and oversleeping on weekends. Since high schools usually impose early schedules, adolescents suffer from permanent social jetlag and thus are a suitable population to study the effects of social jetlag on both academic and cognitive performance. In this study, 796 adolescents aged 12 to 16 reported information about their sleep habits, morningness-eveningness, cognitive abilities and grade point average. Time in bed on both weekdays and weekends were not related to cognitive abilities, and only time in bed on weekdays was related to academic achievement. Social jetlag was negatively related to academic achievement, cognitive abilities (except for vocabulary and verbal fluency abilities) and general cognitive ability (g), whereas morningness-eveningness was slightly positively related to academic achievement and marginally negatively related to inductive reasoning. Results separated by sex/gender indicated that social jetlag may be more detrimental to girls’ performance, as it was negatively related to a greater number of cognitive abilities and grade point average., Ministerio de Ciencia e Innovación (MICINN), Ministerio de Economía y Competitividad (MINECO), Depto. de Psicología Social, del Trabajo y Diferencial, Fac. de Psicología, TRUE, pub

The study aimed at testing chronotype and gender differences in the time of day when humans feel the greatest need for sex and the time of day they actually undertake sexual activity. A Polish sample of 565 participants aged between 18 and 57 was tested. In females, regardless of chronotype, the greatest need for sex occurred between 18:00 and 24:00, but a secondary peak appeared in morning types at 6:00-9:00. In males, the greatest need for sex occurred either in the morning or evening: in evening types at 9:00-12:00 and 18:00-3:00; in neither types at 6:00-9:00 and 18:00-24:00; in morning types at 6:00-12:00 and 18:00-24:00. Considering time of day when subjects were undertaking sexual activity most frequently, this appeared between 18:00-24:00 for all the participants, and prolonged until 3:00 at night in evening type males. Morningness preference was more strongly related to the timing of need for sex than to the timing of actual sexual activity (r = -.275 vs. r = -.174), while the timing of desire and the timing of sexual activity were positively, but moderately related (r = .320)., Depto. de Psicología Social, del Trabajo y Diferencial, Fac. de Psicología, TRUE, pub

This study presents an exceptional collection of 54 Late Pleistocene human remains that correspond to at least three Neanderthal individuals from Simanya Gran, the main gallery of Cova Simanya, located in the northeastern Iberian Peninsula. The collection comprised 53 unpublished remains that were unearthed during the 1970s and an additional tooth discovered during 2021 excavations. The specimens represent an adult with a small stature, a periadolescent aged approximately 11.5 years, and an immature individual aged approximately 7.7 years, thus offering a more complete demographic perspective. The collection encompasses diverse anatomical parts including upper and lower dentition, mandible, vertebrae, and limb bones from both the upper and lower extremities. Attempts to extract aDNA were unsuccessful. Renewed archaeological investigations at Cova Simanya have facilitated the reevaluation of the original stratigraphic context of these remains, leading to the discovery of the additional tooth, aligning with the periadolescent individual. This assemblage is currently the most extensive Neanderthal collection from the northeastern Mediterranean Iberia, offering invaluable insights into the morphology and evolutionary trajectory of Late Pleistocene hominins. Hence, Simanya Neanderthals will enhance our understanding of Neanderthal demographics and evolution, paving the way for an in-depth examination of the morphological diversity and evolutionary context of Iberian Neanderthals., Ministerio de Ciencia e Innovación, Generalitat de Catalunya, Diputació de Barcelona, Fundación Palarq, UAM Tomás y Valiente Program, European Union, Ministerio de Universidades, Xunta de Galicia, European Research Council, Depto. de Geodinámica, Estratigrafía y Paleontología, Fac. de Ciencias Geológicas, TRUE, pub

The aim of this study is to offer preliminary results about the validity of the composite morningness scale (CS) and the early/late preferences scale (PS) in a Peruvian sample. The relationship of both scales with the preferred rising and retiring times was analysed, along with the level of self-reported alertness. In Bohle et al.'s (2001) work, the relationship between morningness and preferred rising and retiring times was higher over the weekend than on weekdays. This difference explained the dispositional nature of morningness, due to the possible lesser influence of time schedules over the weekend in individuals' preferences. This result is replicated in a group of 139 Peruvian undergraduates, aged between 18 and 29 years (M = 21.73), of whom 78.4% were women. The relationship between morningness and (actual) normal rising and retiring times on weekdays and over the weekend is considered. The results partially confirm Bohle et al.'s (2001) hypothesis about preferred rising and retiring times and their relationship with the PS, and actual rising time and its relationship with the CS and PS. The differences in the level of self-reported alertness between morning, intermediate and evening-oriented groups provide support for the validity of both scales. Finally, the scores of CS and PS in Peruvian undergraduates are similar to those found by Smith et al. (2002) in university students from six countries., Fac. de Psicología, TRUE, pub

Existing evidence suggests an association between mood, time-of-day and Morningness-Eveningness (M-E). Since few studies have been carried out among adolescents, in this study daily mood fluctuations were analyzed in the naturalistic school context during two days in order to test how chronotype and time-of-day are related to mood during the school schedule period and check if sleep length is involved in the above relation. A sample of 655 adolescents (12-16 years) reported mood levels (current level of pleasantness) three times during school day (8:10-8:30 h, 10:20-11:40 h, 13:50-14:10 h). They also reported M-E preference and time in bed. Neither age nor sex was related to mood. However, the results indicated that regardless of chronotype mood increased throughout the school day from the lowest morning levels. Moreover, morning types showed better mood compared to other chronotypes, while evening types exhibited the lowest mood. Evening oriented students slept less than other chronotypes, but time in bed was not involved in the relationship between chronotype and mood. These results suggest that it is not shortened sleep duration responsible for decreased mood in evening oriented students., Ministerio Economía y Competitividad (MINECO), Ministerio Ciencia e Innovación (MICINN), National Science Centre (Polonia), Depto. de Personalidad, Evaluación y Psicología Clínica, Fac. de Psicología, TRUE, pub

El presente proyecto es la FASE 2 de continuación del proyecto nº 151 titulado: Innovaciones prácticas y recursos educativos en Psicología Diferencial (FASE 1), que se desarrolló durante el curso académico 2021-22, que dirigió el profesor Juan Francisco Díaz Morales y del que formaban parte como PDI los/as profesores/as: Inmaculada López, Pandelis Perakakis y Mª Dolores Merino. Los objetivos de dicho proyecto fueron: Desarrollar a) innovaciones prácticas y/o aplicadas en la enseñanza de los cinco grandes temas de la asignatura de Psicología Diferencial y b) crear un banco de recursos docentes accesibles en abierto. Dichos objetivos se alcanzaron con éxito. Esta segunda parte del proyecto de innovación está dirigida a la ampliación y utilización de dichos materiales dentro de la dinámica de la clase y a la evaluación de la eficacia de los mismos. Los resultados indican que la implantación de este modelo de aprendizaje activo es eficaz.

Antimicrobial resistance is a global concern, far from being resolved. The need of new drugs against new targets is imminent. In this work, we present a family of aminoalkyl resveratrol derivatives with antibacterial activity inspired by the properties of cationic amphipathic antimicrobial peptides. Surprisingly, the newly designed molecules display modest activity against aerobically growing bacteria but show surprisingly good antimicrobial activity against anaerobic bacteria (Gram-negative and Gram-positive) suggesting specificity towards this bacterial group. Preliminary studies into the action mechanism suggest that activity takes place at the membrane level, while no cross-resistance with traditional antibiotics is observed. Actually, some good synergistic relations with existing antibiotics were found against Gram-negative pathogens. However, some cytotoxicity was observed, despite their low haemolytic activity. Our results show the importance of the balance between positively charged moieties and hydrophobicity to improve antimicrobial activity, setting the stage for the design of new drugs based on these molecules.

Introducción: Compartir “eventos de la bebida” se ha convertido en una práctica habitual entre las personas jóvenes en redes como Instagram. La pandemia por el Covid-19 ha reestructurado tanto sus pautas de consumo de alcohol, como los usos que hacen de las redes sociales. Objetivos y Métodos: Describir en profundidad las pautas de consumo de alcohol y los efectos de este consumo que se muestran en Instagram en unamuestra de 118 jóvenes y adolescentes en España a través de la etnografía digital. Resultados y Conclusiones: Instagram es parte de la fiesta, parte imbricada en la vida cotidiana de las personasjóvenes, en la que se comparten regularmente imágenes deseables de las pautas de consumo de alcohol y sus efectos. Adolescentes y jóvenes construyen un modelo online idealizado de pautas de consumo de alcohol en el que sólo son visibleslos efectos de la fase de desinhibición tras el consumo y se obvian el resto de lasfases de los efectos del alcohol en el organismo. Esfundamental incluir estas nuevasformas de transmisión de las pautas de consumo de alcohol en la normativa española que regula la venta y uso de alcohol., Introduction: Sharing “drinking events” has become a common practice among young people on Instagram. The Covid-19 pandemic hasrestructured both their alcohol consumption patterns and their use of social networks. Objective and Methods: To describe in depth the patterns of alcohol consumption and the effects of this consumption shown on Instagram in a sample of 118 young people and adolescentsin Spain through digital ethnography. Results and Conclusions: Instagram is part of the party, part embedded in the daily lives of young people, in which desirable images of drinking patterns and their effects are regularly shared. Adolescents and young people build an idealized online model of alcohol consumption patterns in which only the effects of the disinhibition phase after consumption are visible and the rest of the phases of the effects of alcohol on the body are ignored. Itis essential to include these new forms of transmission of alcohol consumption patternsin the Spanish regulations that regulate the sale and use of alcohol.

The brain has great capacity for computation and efficient resolution of complex problems, far surpassing modern computers. Neuromorphic engineering seeks to mimic the basic principles of the brain to develop systems capable of achieving such capabilities. In the neuromorphic field, navigation systems are of great interest due to their potential applicability to robotics, although these systems are still a challenge to be solved. This work proposes a spike-based robotic navigation and environment pseudomapping system formed by a bioinspired hippocampal memory model connected to a posterior parietal cortex (PPC) model. The hippocampus is in charge of maintaining a representation of an environment state map, and the PPC is in charge of local decision-making. This system is implemented on the SpiNNaker hardware platform using spiking neural networks. A set of real-time experiments are applied to demonstrate the correct functioning of the system in virtual and physical environments on a robotic platform. The system is able to navigate through the environment to reach a goal position starting from an initial position, avoiding obstacles and mapping the environment. To the best of the authors’ knowledge, this is the first implementation of an environment pseudomapping system with dynamic learning based on a bioinspired hippocampal memory. © 2023 The Authors. Advanced Intelligent Systems published by Wiley-VCH GmbH.

Background: Among all the cancers known today, prostate cancer is one of the most commonly diagnosed in men. With modern advances in medicine, its mortality has been considerably reduced. However, it is still a leading type of cancer in terms of deaths.The diagnosis of prostate cancer is mainly conducted by biopsy test. From this test, Whole Slide Images are obtained, from which pathologists diagnose the cancer according to the Gleason scale. Within this scale from 1 to 5, grade 3and above is considered malignant tissue. Several studies have shown an inter- observer discrepancy between pathologists in assigning the value of the Gleason scale. Due to the recent advances in artificial intelligence, its application to the computational pathology field with the aim of supporting and providing a second opinion to the professional is of great interest. Method:In this work, the inter-observer variability of a local dataset of 80 whole-slide images annotated by a team of 5 pathologists from the same group was analyzed at both area and label level. Four approaches were followed to train six different Convolutional Neural Network architectures, which were evaluated on the same data set on which the inter-observer variability was analyzed. Results: An inter-observer variability of 0.6946k was obtained, with 46% discrepancy in terms of area size of the annotations performed by the pathologists. The best trained models achieved 0.826±0.014k on the test set when trained with data from the same source. Conclusions: The obtained results show that deep learning-based automatic diagnosi s systems could help reduce the widely-known inter-observer variability that is present among pathologists and support them in their decision, serving as a second opinion or as a triage tool for medical centers.

This study presents an exceptional collection of 54 Late Pleistocene human remains that correspond to at least three Neanderthal individuals from Simanya Gran, the main gallery of Cova Simanya, located in the northeastern Iberian Peninsula. The collection comprised 53 unpublished remains that were unearthed during the 1970s and an additional tooth discovered during 2021 excavations. The specimens represent an adult with a small stature, a periadolescent aged approximately 11.5 years, and an immature individual aged approximately 7.7 years, thus offering a more complete demographic perspective. The collection encompasses diverse anatomical parts including upper and lower dentition, mandible, vertebrae, and limb bones from both the upper and lower extremities. Attempts to extract aDNA were unsuccessful. Renewed archaeological investigations at Cova Simanya have facilitated the reevaluation of the original stratigraphic context of these remains, leading to the discovery of the additional tooth, aligning with the periadolescent individual. This assemblage is currently the most extensive Neanderthal collection from the northeastern Mediterranean Iberia, offering invaluable insights into the morphology and evolutionary trajectory of Late Pleistocene hominins. Hence, Simanya Neanderthals will enhance our understanding of Neanderthal demographics and evolution, paving the way for an in-depth examination of the morphological diversity and evolutionary context of Iberian Neanderthals.

Este artículo presenta una práctica de laboratorio impartida en el contexto de la asignatura Sistemas de Rehabilitación y Ayuda a la Discapacidad, la cual se imparte como optativa en el Grado en Ingeniería de la Salud – Mención en Ingeniería Biomédica. El objetivo principal de dicha práctica es la de adquirir la capacidad de desarrollar un dispositivo enfocado a la accesibilidad, el cual permita controlar el ratón del ordenador únicamente mediante gestos realizados con las manos. Los dispositivos y herramientas empleados para dicho fin son el hardware Leap Motion, que recoge los movimientos de las manos y los dedos gracias a los sensores de los que se compone, junto con el entorno de desarrollo Visual Studio, en el que se desarrolla una aplicación de escritorio mediante Windows Forms, .NET y C#. El proceso de desarrollo está guiado y documentado, aportando al alumno todo un entorno base sobre el que construir e ir aprendiendo mientras se avanza en el desarrollo. El proyecto a desarrollar por el alumno abarca competencias clave propias del grado en el que se lleva a cabo, incluyendo la resolución de problemas de carácter multidisciplinar, además de la programación orientada al desarrollo de dispositivos asistenciales., This article presents a laboratory practice given in the context of the course Rehabilitation Systems and Disability Assistance, which is taught as an elective in the Degree in Health Engineering - Mention in Biomedical Engineering. The main objective of this practice is to acquire the ability to develop a device focused on accessibility, which allows to control the computer mouse using only hand gestures. The devices and tolos used for this purpose are the Leap Motion hardware, which collects the movements of the hands and fingers thanks to the sensors of which it is composed, along with the Visual Studio development environment, in which a desktop application is developed using Windows Forms, .NET and C#. The development process is guided and documented, providing the student with a base environment on which to build and learn as the development progresses. The project to be developed by the student covers key competences of the degree in which it is carried out, including the resolution of multidisciplinary problems, as well as programming oriented to the development of assistance devices.

La exitosa realización del “III Congreso Internacional de Ética en Cuenca, Ciudad Universitaria”, los días 23, 24 y 25 de noviembre del año dos mil veinte y dos, bajo la responsabilidad de la Universidad Católica de Cuenca y en el marco institucional de la Red Universitaria y Ciudadana de Ética y Bioética, RUCEB, de la cual esta distinguida institución forma parte junto a la Universidad del Azuay, Universidad de Cuenca y Universidad Politécnica Salesiana, fue el momento propicio para que el ya sostenido trabajo reflexivo sobre la ética en diferentes ámbitos del quehacer social sea presentado por estudiantes y profesores, locales, nacionales y extranjeros.

La exitosa realización del “III Congreso Internacional de Ética en Cuenca, Ciudad Universitaria”, los días 23, 24 y 25 de noviembre del año dos mil veinte y dos, bajo la responsabilidad de la Universidad Católica de Cuenca y en el marco institucional de la Red Universitaria y Ciudadana de Ética y Bioética, RUCEB, de la cual esta distinguida institución forma parte junto a la Universidad del Azuay, Universidad de Cuenca y Universidad Politécnica Salesiana, fue el momento propicio para que el ya sostenido trabajo reflexivo sobre la ética en diferentes ámbitos del quehacer social sea presentado por estudiantes y profesores, locales, nacionales y extranjeros.

This paper aims to assess the opinions of Physical Education teachers (PET) about their teaching intervention at a coeducational level. A further objective was to analyse PETs self-perceptions of their mixed and training interventions to describe possible training gaps. The qualitative study involved 191 high school PET from Andalusia (Spain). Some questions were conducted about three dimensions: gender stereotypes and attitudes in PE; teaching performance in coeducation, and coeducational teachers’ professional development in PE. The study's main results indicated that most teachers had neither different expectations of boys and girls nor a different way of treating them and, more than half of the participants considered themselves to be competent in coeducation. They preferred to receive training other than coeducational training. However, almost three-quarters of the sample had not received any coeducation training, or it was self-taught. The main conclusion is that PET consider that they have proper coeducational behaviour. The results showed that current teachers had improved their teaching intervention regarding gender equality compared to previous studies. The present study has had a contribution to the Sustainable Development Goals (SDG )goals 4 and 5, quality education and gender equality, respectively and can be a reference for future research related to coeducation for teachers., Este trabajo tiene como objetivo evaluar la opinión de profesorado de Educación Física (PET) sobre su intervención docente en un nivel coeducativo. Otro de los objetivos fue analizar las autopercepciones de los PET (del inglés Physical Education Teacher, “PET") sobre sus intervenciones coeducativas y formativas para describir posibles lagunas formativas. En este estudio cualitativo han participado 191 PET de secundaria y bachillerato de Andalucía (España). Se realizaron preguntas sobre tres dimensiones: estereotipos y actitudes de género en EF; desempeño docente en coeducación y desarrollo profesional del profesorado coeducativo en EF. Los principales resultados del estudio indicaron que la mayoría de los docentes no tenían expectativas diferentes entre niños y niñas ni una forma diferente de tratarlos y más de la mitad de los participantes se consideraban competentes en coeducación. Preferían recibir cursos de especialización distintos a cursos de coeducación. Sin embargo, casi las tres cuartas partes de la muestra no había recibido ninguna formación en coeducación o era autodidacta. La principal conclusión es que los PET consideran que tienen un comportamiento coeducativo adecuado. Los resultados mostraron que los docentes actuales habían mejorado su intervención docente en materia de igualdad de género en comparación con estudios previos. El presente estudio pretende contribuir a las metas de los Objetivos del Desarrollo Sostenible (ODS) 4 y 5, educación de calidad e igualdad de género respectivamente y puede ser un referente para futuras investigaciones relacionadas con la coeducación en docentes.

Antimicrobial resistance is a global concern, far from being resolved. The need of new drugs against new targets is imminent. In this work, we present a family of aminoalkyl resveratrol derivatives with antibacterial activity inspired by the properties of cationic amphipathic antimicrobial peptides. Surprisingly, the newly designed molecules display modest activity against aerobically growing bacteria but show surprisingly good antimicrobial activity against anaerobic bacteria (Gram-negative and Gram-positive) suggesting specificity towards this bacterial group. Preliminary studies into the action mechanism suggest that activity takes place at the membrane level, while no cross-resistance with traditional antibiotics is observed. Actually, some good synergistic relations with existing antibiotics were found against Gram-negative pathogens. However, some cytotoxicity was observed, despite their low haemolytic activity. Our results show the importance of the balance between positively charged moieties and hydrophobicity to improve antimicrobial activity, setting the stage for the design of new drugs based on these molecules.

The brain has great capacity for computation and efficient resolution of complex problems, far surpassing modern computers. Neuromorphic engineering seeks to mimic the basic principles of the brain to develop systems capable of achieving such capabilities. In the neuromorphic field, navigation systems are of great interest due to their potential applicability to robotics, although these systems are still a challenge to be solved. This work proposes a spike-based robotic navigation and environment pseudomapping system formed by a bioinspired hippocampal memory model connected to a posterior parietal cortex (PPC) model. The hippocampus is in charge of maintaining a representation of an environment state map, and the PPC is in charge of local decision-making. This system is implemented on the SpiNNaker hardware platform using spiking neural networks. A set of real-time experiments are applied to demonstrate the correct functioning of the system in virtual and physical environments on a robotic platform. The system is able to navigate through the environment to reach a goal position starting from an initial position, avoiding obstacles and mapping the environment. To the best of the authors’ knowledge, this is the first implementation of an environment pseudomapping system with dynamic learning based on a bioinspired hippocampal memory. © 2023 The Authors. Advanced Intelligent Systems published by Wiley-VCH GmbH.

Computational pathology targets the automatic analysis of Whole Slide Images (WSI). WSIs are high-resolution digitized histopathology images, stained with chemical reagents to highlight specific tissue structures and scanned via whole slide scanners. The application of different parameters during WSI acquisition may lead to stain color heterogeneity, especially considering samples collected from several medical centers. Dealing with stain color heterogeneity often limits the robustness of methods developed to analyze WSIs, in particular Convolutional Neural Networks (CNN), the state-of-the-art algorithm for most computational pathology tasks. Stain color heterogeneity is still an unsolved problem, although several methods have been developed to alleviate it, such as Hue-Saturation-Contrast (HSC) color augmentation and stain augmentation methods. The goal of this paper is to present Data-Driven Color Augmentation (DDCA), a method to improve the efficiency of color augmentation methods by increasing the reliability of the samples used for training computational pathology models. During CNN training, a database including over 2 million H&E color variations collected from private and public datasets is used as a reference to discard augmented data with color distributions that do not correspond to realistic data. DDCA is applied to HSC color augmentation, stain augmentation and H&E-adversarial networks in colon and prostate cancer classification tasks. DDCA is then compared with 11 state-of-the-art baseline methods to handle color heterogeneity, showing that it can substantially improve classification performance on unseen data including heterogeneous color variations.

This article aims to identify the incidence of educational leadership in the teaching and learning processes demanded by 21st-century education, applied to students in grades 10-11 of official institutions located in the Andean region of Colombia. The study has a qualitative focus, descriptive scope, and cross-sectional design. 62 individuals participated, including 25 teachers and 37 students from official educational institutions in the departments of Cundinamarca, Antioquia, Tolima, and Huila. The influence of leadership in the classroom was assessed through semi-structured interviews. The data analysis was conducted using Atlas.ti software version 2023 for Windows. The results indicated that teachers considered as educational leaders are aware of improving teaching and learning processes to produce significant results. However, there is a tendency to focus on content delivery, with little attention to the development of students' leadership skills. In conclusion, students in official educational institutions in the Andean region of Colombia are not developing the skills demanded by 21st-century education in the teaching and learning processes., Este artículo tiene como objetivo identificar la incidencia del liderazgo educativo en los procesos de enseñanza y aprendizaje que demanda la educación del siglo XXI, aplicados a estudiantes de los niveles 10-11 de las instituciones oficiales, ubicadas en la región andina de Colombia. El estudio es de enfoque cualitativo, alcance descriptivo y diseño transversal. Participaron 62 personas, (n =25 docentes y n =37 estudiantes) de instituciones educativas oficiales de los departamentos de Cundinamarca, Antioquia, Tolima y Huila, a quienes se les evaluó la influencia del liderazgo en el aula de clase, a través de entrevistas semiestructuradas. Para el análisis de los datos se usó el software Atlas.ti versión 2023 para Windows. El resultado indicó, que los docentes considerados líderes educativos son consientes de mejorar los procesos de enseñanza y aprendizaje para producir resultados significativos, además, se evidencia una inclinación por la enseñanza de contenido y prestan poco interés al desarrollo de las capacidades de liderazgo de los estudiantes. Se concluye que los estudiantes de las instituciones educativas oficiales de la región Andina de Colombia, no desarrollan las habilidades que demanda la educación del siglo XXI en los procesos de enseñanza y aprendizaje.

Introducción: Compartir “eventos de la bebida” se ha convertido en una práctica habitual entre las personas jóvenes en redes como Instagram. La pandemia por el Covid-19 ha reestructurado tanto sus pautas de consumo de alcohol, como los usos que hacen de las redes sociales. Objetivos y Métodos: Describir en profundidad las pautas de consumo de alcohol y los efectos de este consumo que se muestran en Instagram en unamuestra de 118 jóvenes y adolescentes en España a través de la etnografía digital. Resultados y Conclusiones: Instagram es parte de la fiesta, parte imbricada en la vida cotidiana de las personasjóvenes, en la que se comparten regularmente imágenes deseables de las pautas de consumo de alcohol y sus efectos. Adolescentes y jóvenes construyen un modelo online idealizado de pautas de consumo de alcohol en el que sólo son visibleslos efectos de la fase de desinhibición tras el consumo y se obvian el resto de lasfases de los efectos del alcohol en el organismo. Esfundamental incluir estas nuevasformas de transmisión de las pautas de consumo de alcohol en la normativa española que regula la venta y uso de alcohol., Introduction: Sharing “drinking events” has become a common practice among young people on Instagram. The Covid-19 pandemic hasrestructured both their alcohol consumption patterns and their use of social networks. Objective and Methods: To describe in depth the patterns of alcohol consumption and the effects of this consumption shown on Instagram in a sample of 118 young people and adolescentsin Spain through digital ethnography. Results and Conclusions: Instagram is part of the party, part embedded in the daily lives of young people, in which desirable images of drinking patterns and their effects are regularly shared. Adolescents and young people build an idealized online model of alcohol consumption patterns in which only the effects of the disinhibition phase after consumption are visible and the rest of the phases of the effects of alcohol on the body are ignored. Itis essential to include these new forms of transmission of alcohol consumption patternsin the Spanish regulations that regulate the sale and use of alcohol.

Background: Among all the cancers known today, prostate cancer is one of the most commonly diagnosed in men. With modern advances in medicine, its mortality has been considerably reduced. However, it is still a leading type of cancer in terms of deaths.The diagnosis of prostate cancer is mainly conducted by biopsy test. From this test, Whole Slide Images are obtained, from which pathologists diagnose the cancer according to the Gleason scale. Within this scale from 1 to 5, grade 3and above is considered malignant tissue. Several studies have shown an inter- observer discrepancy between pathologists in assigning the value of the Gleason scale. Due to the recent advances in artificial intelligence, its application to the computational pathology field with the aim of supporting and providing a second opinion to the professional is of great interest. Method:In this work, the inter-observer variability of a local dataset of 80 whole-slide images annotated by a team of 5 pathologists from the same group was analyzed at both area and label level. Four approaches were followed to train six different Convolutional Neural Network architectures, which were evaluated on the same data set on which the inter-observer variability was analyzed. Results: An inter-observer variability of 0.6946k was obtained, with 46% discrepancy in terms of area size of the annotations performed by the pathologists. The best trained models achieved 0.826±0.014k on the test set when trained with data from the same source. Conclusions: The obtained results show that deep learning-based automatic diagnosi s systems could help reduce the widely-known inter-observer variability that is present among pathologists and support them in their decision, serving as a second opinion or as a triage tool for medical centers.

Bis(indolyl)methanes (BIMs) are a class of compounds that have been recognized as an important core in the design of drugs with important pharmacological properties, such as promising anticancer and antiparasitic activities. Here, we explored the biological activity of the BIM core functionalized with different (hetero)aromatic moieties. We synthesized substituted BIM derivatives with triphenylamine, N,N-dimethyl-1-naphthylamine and 8-hydroxylquinolyl groups, studied their photophysical properties and evaluated their in vitro antiproliferative and antiparasitic activities. The triphenylamine BIM derivative 2a displayed an IC50 of 3.21, 3.30 and 3.93 μM against Trypanosoma brucei, Leishmania major and HT-29 cancer cell line, respectively. The selectivity index demonstrated that compound 2a was up to eight-fold more active against the parasites and HT-29 than against the healthy cell line MRC-5. Fluorescence microscopy studies with MRC-5 cells and T. brucei parasites incubated with derivative 2a indicate that the compound seems to accumulate in the cell’s mitochondria and in the parasite’s nucleus. In conclusion, the BIM scaffold functionalized with the triphenylamine moiety proved to be the most promising antiparasitic and anticancer agent of this series.

Antimicrobial resistance is a global concern, far from being resolved. The need of new drugs against new targets is imminent. In this work, we present a family of aminoalkyl resveratrol derivatives with antibacterial activity inspired by the properties of cationic amphipathic antimicrobial peptides. Surprisingly, the newly designed molecules display modest activity against aerobically growing bacteria but show surprisingly good antimicrobial activity against anaerobic bacteria (Gram-negative and Gram-positive) suggesting specificity towards this bacterial group. Preliminary studies into the action mechanism suggest that activity takes place at the membrane level, while no cross-resistance with traditional antibiotics is observed. Actually, some good synergistic relations with existing antibiotics were found against Gram-negative pathogens. However, some cytotoxicity was observed, despite their low haemolytic activity. Our results show the importance of the balance between positively charged moieties and hydrophobicity to improve antimicrobial activity, setting the stage for the design of new drugs based on these molecules.

This study presents an exceptional collection of 54 Late Pleistocene human remains that correspond to at least three Neanderthal individuals from Simanya Gran, the main gallery of Cova Simanya, located in the northeastern Iberian Peninsula. The collection comprised 53 unpublished remains that were unearthed during the 1970s and an additional tooth discovered during 2021 excavations. The specimens represent an adult with a small stature, a periadolescent aged approximately 11.5 years, and an immature individual aged approximately 7.7 years, thus offering a more complete demographic perspective. The collection encompasses diverse anatomical parts including upper and lower dentition, mandible, vertebrae, and limb bones from both the upper and lower extremities. Attempts to extract aDNA were unsuccessful. Renewed archaeological investigations at Cova Simanya have facilitated the reevaluation of the original stratigraphic context of these remains, leading to the discovery of the additional tooth, aligning with the periadolescent individual. This assemblage is currently the most extensive Neanderthal collection from the northeastern Mediterranean Iberia, offering invaluable insights into the morphology and evolutionary trajectory of Late Pleistocene hominins. Hence, Simanya Neanderthals will enhance our understanding of Neanderthal demographics and evolution, paving the way for an in-depth examination of the morphological diversity and evolutionary context of Iberian Neanderthals., This study presents an exceptional collection of 54 Late Pleistocene human remains that correspond to at least three Neanderthal individuals from Simanya Gran, the main gallery of Cova Simanya, located in the northeastern Iberian Peninsula. The collection comprised 53 unpublished remains that were unearthed during the 1970s and an additional tooth discovered during 2021 excavations. The specimens represent an adult with a small stature, a periadolescent aged approximately 11.5 years, and an immature individual aged approximately 7.7 years, thus offering a more complete demographic perspective. The collection encompasses diverse anatomical parts including upper and lower dentition, mandible, vertebrae, and limb bones from both the upper and lower extremities. Attempts to extract aDNA were unsuccessful. Renewed archaeological investigations at Cova Simanya have facilitated the reevaluation of the original stratigraphic context of these remains, leading to the discovery of the additional tooth, aligning with the periadolescent individual. This assemblage is currently the most extensive Neanderthal collection from the northeastern Mediterranean Iberia, offering invaluable insights into the morphology and evolutionary trajectory of Late Pleistocene hominins. Hence, Simanya Neanderthals will enhance our understanding of Neanderthal demographics and evolution, paving the way for an in-depth examination of the morphological diversity and evolutionary context of Iberian Neanderthals., This study presents an exceptional collection of 54 Late Pleistocene human remains that correspond to at least three Neanderthal individuals from Simanya Gran, the main gallery of Cova Simanya, located in the northeastern Iberian Peninsula. The collection comprised 53 unpublished remains that were unearthed during the 1970s and an additional tooth discovered during 2021 excavations. The specimens represent an adult with a small stature, a periadolescent aged approximately 11.5 years, and an immature individual aged approximately 7.7 years, thus offering a more complete demographic perspective. The collection encompasses diverse anatomical parts including upper and lower dentition, mandible, vertebrae, and limb bones from both the upper and lower extremities. Attempts to extract aDNA were unsuccessful. Renewed archaeological investigations at Cova Simanya have facilitated the reevaluation of the original stratigraphic context of these remains, leading to the discovery of the additional tooth, aligning with the periadolescent individual. This assemblage is currently the most extensive Neanderthal collection from the northeastern Mediterranean Iberia, offering invaluable insights into the morphology and evolutionary trajectory of Late Pleistocene hominins. Hence, Simanya Neanderthals will enhance our understanding of Neanderthal demographics and evolution, paving the way for an in-depth examination of the morphological diversity and evolutionary context of Iberian Neanderthals.

Background: The distinction between in situ melanoma (MIS) and invasive melanoma is challenging even for expert dermatologists. The use of pretrained convolutional neural networks (CNNs) as ancillary decision systems needs further research. Aim To develop, validate and compare three deep transfer learning (DTL) algorithms to predict MIS vs. invasive melanoma and melanoma with a Breslow thickness (BT) of < 0.8 mm vs. ≥ 0.8 mm. Methods: A dataset of 1315 dermoscopic images of histopathologically confirmed melanomas was created from Virgen del Rocio University Hospital and open repositories of the International Skin Imaging Collaboration archive and Polesie S et al. (Dermatol Pract Concept 2021; 11:e2021079). The images were labelled as MIS or invasive melanoma and < 0.8 mm or ≥ 0.8 mm of BT. We conducted three trainings, and overall means for receiver operating characteristic (ROC) curves, sensitivity, specificity, positive and negative predictive value, and balanced diagnostic accuracy outcomes were evaluated on the test set with ResNetV2, EfficientNetB6 and InceptionV3. The results of 10 dermatologists were compared with the algorithms. Grad-CAM gradient maps were generated, highlighting relevant areas considered by the CNNs within the images. Results: EfficientNetB6 achieved the highest diagnostic accuracy for the comparison between MIS vs. invasive melanoma (61%) and BT < 0.8 mm vs. ≥ 0.8 mm (75%). For the BT comparison, ResNetV2 with an area under the ROC curve of 0.76 and InceptionV3 with an area under the ROC curve of 0.75, outperformed the results obtained by the dermatologist group with an area under the ROC curve of 0.70. Conclusion: EfficientNetB6 recorded the best prediction results, outperforming the dermatologists for the comparison of 0.8 mm of BT. DTL could be an ancillary aid to support dermatologists’ decisions in the near future.

La exitosa realización del “III Congreso Internacional de Ética en Cuenca, Ciudad Universitaria”, los días 23, 24 y 25 de noviembre del año dos mil veinte y dos, bajo la responsabilidad de la Universidad Católica de Cuenca y en el marco institucional de la Red Universitaria y Ciudadana de Ética y Bioética, RUCEB, de la cual esta distinguida institución forma parte junto a la Universidad del Azuay, Universidad de Cuenca y Universidad Politécnica Salesiana, fue el momento propicio para que el ya sostenido trabajo reflexivo sobre la ética en diferentes ámbitos del quehacer social sea presentado por estudiantes y profesores, locales, nacionales y extranjeros.

La exitosa realización del “III Congreso Internacional de Ética en Cuenca, Ciudad Universitaria”, los días 23, 24 y 25 de noviembre del año dos mil veinte y dos, bajo la responsabilidad de la Universidad Católica de Cuenca y en el marco institucional de la Red Universitaria y Ciudadana de Ética y Bioética, RUCEB, de la cual esta distinguida institución forma parte junto a la Universidad del Azuay, Universidad de Cuenca y Universidad Politécnica Salesiana, fue el momento propicio para que el ya sostenido trabajo reflexivo sobre la ética en diferentes ámbitos del quehacer social sea presentado por estudiantes y profesores, locales, nacionales y extranjeros.

The large amounts of astrophysical data being provided by existing and future instrumentation require efficient and fast analysis tools. Transfer learning is a new technique promising higher accuracy in the derived data products, with information from one domain being transferred to improve the accuracy of a neural network model in another domain. In this work, we demonstrate the feasibility of applying the deep transfer learning (DTL) approach to high-resolution spectra in the framework of photospheric stellar parameter determination. To this end, we used 14 stars of the CARMENES survey sample with interferometric angular diameters to calculate the effective temperature, as well as six M dwarfs that are common proper motion companions to FGK-type primaries with known metallicity. After training a deep learning (DL) neural network model on synthetic PHOENIX-ACES spectra, we used the internal feature representations together with those 14+6 stars with independent parameter measurements as a new input for the transfer process. We compare the derived stellar parameters of a small sample of M dwarfs kept out of the training phase with results from other methods in the literature. Assuming that temperatures from bolometric luminosities and interferometric radii and metallicities from FGK+M binaries are sufficiently accurate, DTL provides a higher accuracy than our previous state-of-the-art DL method (mean absolute differences improve by 20 K for temperature and 0.2 dex for metallicity from DL to DTL when compared with reference values from interferometry and FGK+M binaries). Furthermore, the machine learning (internal) precision of DTL also improves as uncertainties are five times smaller on average. These results indicate that DTL is a robust tool for obtaining M-dwarf stellar parameters comparable to those obtained from independent estimations for well-known stars.