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71 results on '"Moiseev S."'

1. Eosinophilic granulomatosis with polyangiitis onset in severe asthma patients on monoclonal antibodies targeting type 2 inflammation: Report from the European EGPA study group

Author: Caminati, M, Fassio, A, Alberici, F, Baldini, C, Bello, F, Cameli, P, Conticini, E, Cottin, V, Crimi, C, Dagna, L, Delvino, P, Deroux, A, Duran, E, Espigol-Frigole, G, Karadag, O, Maule, M, Moiseev, S, Monti, S, Moroni, L, Padoan, R, Pugnet, G, Taille, C, Toniati, P, Vaglio, A, Emmi, G, Caminati, M, Fassio, A, Alberici, F, Baldini, C, Bello, F, Cameli, P, Conticini, E, Cottin, V, Crimi, C, Dagna, L, Delvino, P, Deroux, A, Duran, E, Espigol-Frigole, G, Karadag, O, Maule, M, Moiseev, S, Monti, S, Moroni, L, Padoan, R, Pugnet, G, Taille, C, Toniati, P, Vaglio, A, and Emmi, G
Published: 2024

2. Evidence-Based Guideline for the diagnosis and management of eosinophilic granulomatosis with polyangiitis

Author: Emmi, G, Bettiol, A, Gelain, E, Bajema, I, Berti, A, Burns, S, Cid, M, Cohen Tervaert, J, Cottin, V, Durante, E, Holle, J, Mahr, A, Del Pero, M, Marvisi, C, Mills, J, Moiseev, S, Moosig, F, Mukhtyar, C, Neumann, T, Olivotto, I, Salvarani, C, Seeliger, B, Sinico, R, Taillé, C, Terrier, B, Venhoff, N, Bertsias, G, Guillevin, L, Jayne, D, Vaglio, A, Emmi G., Bettiol A., Gelain E., Bajema I. M., Berti A., Burns S., Cid M. C., Cohen Tervaert J. W., Cottin V., Durante E., Holle J. U., Mahr A. D., Del Pero M. M., Marvisi C., Mills J., Moiseev S., Moosig F., Mukhtyar C., Neumann T., Olivotto I., Salvarani C., Seeliger B., Sinico R. A., Taillé C., Terrier B., Venhoff N., Bertsias G., Guillevin L., Jayne D. R. W., Vaglio A., Emmi, G, Bettiol, A, Gelain, E, Bajema, I, Berti, A, Burns, S, Cid, M, Cohen Tervaert, J, Cottin, V, Durante, E, Holle, J, Mahr, A, Del Pero, M, Marvisi, C, Mills, J, Moiseev, S, Moosig, F, Mukhtyar, C, Neumann, T, Olivotto, I, Salvarani, C, Seeliger, B, Sinico, R, Taillé, C, Terrier, B, Venhoff, N, Bertsias, G, Guillevin, L, Jayne, D, Vaglio, A, Emmi G., Bettiol A., Gelain E., Bajema I. M., Berti A., Burns S., Cid M. C., Cohen Tervaert J. W., Cottin V., Durante E., Holle J. U., Mahr A. D., Del Pero M. M., Marvisi C., Mills J., Moiseev S., Moosig F., Mukhtyar C., Neumann T., Olivotto I., Salvarani C., Seeliger B., Sinico R. A., Taillé C., Terrier B., Venhoff N., Bertsias G., Guillevin L., Jayne D. R. W., and Vaglio A.
Abstract: Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis, characterized by asthma, eosinophilia and granulomatous or vasculitic involvement of several organs. The diagnosis and management of EGPA are often challenging and require an integrated, multidisciplinary approach. Current practice relies on recommendations and guidelines addressing the management of ANCA-associated vasculitis and not specifically developed for EGPA. Here, we present evidence-based, cross-discipline guidelines for the diagnosis and management of EGPA that reflect the substantial advances that have been made in the past few years in understanding the pathogenesis, clinical subphenotypes and differential diagnosis of the disease, as well as the availability of new treatment options. Developed by a panel of European experts on the basis of literature reviews and, where appropriate, expert opinion, the 16 statements and five overarching principles cover the diagnosis and staging, treatment, outcome and follow-up of EGPA. These recommendations are primarily intended to be used by healthcare professionals, pharmaceutical industries and drug regulatory authorities, to guide clinical practice and decision-making in EGPA. These guidelines are not intended to limit access to medications by healthcare agencies, nor to impose a fixed order on medication use.
Published: 2023

3. Rituximab in Membranous Nephropathy

Author: Gauckler, P., Shin, J.I., Alberici, F., Audard, V., Bruchfeld, A., Busch, M., Cheung, C.K., Crnogorac, M., Delbarba, E., Eller, K., Faguer, S., Galesic, K., Griffin, Sian, Hoogen, M.W.F. van den, Hrušková, Z., Jeyabalan, A., Karras, A., King, C., Kohli, H.S., Mayer, G., Maas, R.J.H., Muto, M., Moiseev, S., Odler, B., Pepper, R.J., Quintana, L.F., Radhakrishnan, J., Ramachandran, R., Salama, A.D., Schönermarck, U., Segelmark, M., Smith, L., Tesař, V., Wetzels, J., Willcocks, L., Windpessl, M., Zand, L., Zonozi, R., Kronbichler, A., Gauckler, P., Shin, J.I., Alberici, F., Audard, V., Bruchfeld, A., Busch, M., Cheung, C.K., Crnogorac, M., Delbarba, E., Eller, K., Faguer, S., Galesic, K., Griffin, Sian, Hoogen, M.W.F. van den, Hrušková, Z., Jeyabalan, A., Karras, A., King, C., Kohli, H.S., Mayer, G., Maas, R.J.H., Muto, M., Moiseev, S., Odler, B., Pepper, R.J., Quintana, L.F., Radhakrishnan, J., Ramachandran, R., Salama, A.D., Schönermarck, U., Segelmark, M., Smith, L., Tesař, V., Wetzels, J., Willcocks, L., Windpessl, M., Zand, L., Zonozi, R., and Kronbichler, A.
Abstract: Contains fulltext : 245229.pdf (Publisher’s version ) (Open Access), Membranous nephropathy (MN) is the most common cause of primary nephrotic syndrome among adults. The identification of phospholipase A2 receptor (PLA2R) as target antigen in most patients changed the management of MN dramatically, and provided a rationale for B-cell depleting agents such as rituximab. The efficacy of rituximab in inducing remission has been investigated in several studies, including 3 randomized controlled trials, in which complete and partial remission of proteinuria was achieved in approximately two-thirds of treated patients. Due to its favorable safety profile, rituximab is now considered a first-line treatment option for MN, especially in patients at moderate and high risk of deterioration in kidney function. However, questions remain about how to best use rituximab, including the optimal dosing regimen, a potential need for maintenance therapy, and assessment of long-term safety and efficacy outcomes. In this review, we provide an overview of the current literature and discuss both strengths and limitations of "the new standard."
Published: 2021

4. Rituximab in Membranous Nephropathy

Author: Gauckler, P., Shin, J.I., Alberici, F., Audard, V., Bruchfeld, A., Busch, M., Cheung, C.K., Crnogorac, M., Delbarba, E., Eller, K., Faguer, S., Galesic, K., Griffin, Sian, Hoogen, M.W.F. van den, Hrušková, Z., Jeyabalan, A., Karras, A., King, C., Kohli, H.S., Mayer, G., Maas, R.J.H., Muto, M., Moiseev, S., Odler, B., Pepper, R.J., Quintana, L.F., Radhakrishnan, J., Ramachandran, R., Salama, A.D., Schönermarck, U., Segelmark, M., Smith, L., Tesař, V., Wetzels, J., Willcocks, L., Windpessl, M., Zand, L., Zonozi, R., Kronbichler, A., Gauckler, P., Shin, J.I., Alberici, F., Audard, V., Bruchfeld, A., Busch, M., Cheung, C.K., Crnogorac, M., Delbarba, E., Eller, K., Faguer, S., Galesic, K., Griffin, Sian, Hoogen, M.W.F. van den, Hrušková, Z., Jeyabalan, A., Karras, A., King, C., Kohli, H.S., Mayer, G., Maas, R.J.H., Muto, M., Moiseev, S., Odler, B., Pepper, R.J., Quintana, L.F., Radhakrishnan, J., Ramachandran, R., Salama, A.D., Schönermarck, U., Segelmark, M., Smith, L., Tesař, V., Wetzels, J., Willcocks, L., Windpessl, M., Zand, L., Zonozi, R., and Kronbichler, A.
Abstract: Contains fulltext : 245229.pdf (Publisher’s version ) (Open Access), Membranous nephropathy (MN) is the most common cause of primary nephrotic syndrome among adults. The identification of phospholipase A2 receptor (PLA2R) as target antigen in most patients changed the management of MN dramatically, and provided a rationale for B-cell depleting agents such as rituximab. The efficacy of rituximab in inducing remission has been investigated in several studies, including 3 randomized controlled trials, in which complete and partial remission of proteinuria was achieved in approximately two-thirds of treated patients. Due to its favorable safety profile, rituximab is now considered a first-line treatment option for MN, especially in patients at moderate and high risk of deterioration in kidney function. However, questions remain about how to best use rituximab, including the optimal dosing regimen, a potential need for maintenance therapy, and assessment of long-term safety and efficacy outcomes. In this review, we provide an overview of the current literature and discuss both strengths and limitations of "the new standard."
Published: 2021

5. Rituximab in Membranous Nephropathy

Author: Gauckler, P., Shin, J.I., Alberici, F., Audard, V., Bruchfeld, A., Busch, M., Cheung, C.K., Crnogorac, M., Delbarba, E., Eller, K., Faguer, S., Galesic, K., Griffin, Sian, Hoogen, M.W.F. van den, Hrušková, Z., Jeyabalan, A., Karras, A., King, C., Kohli, H.S., Mayer, G., Maas, R.J.H., Muto, M., Moiseev, S., Odler, B., Pepper, R.J., Quintana, L.F., Radhakrishnan, J., Ramachandran, R., Salama, A.D., Schönermarck, U., Segelmark, M., Smith, L., Tesař, V., Wetzels, J., Willcocks, L., Windpessl, M., Zand, L., Zonozi, R., Kronbichler, A., Gauckler, P., Shin, J.I., Alberici, F., Audard, V., Bruchfeld, A., Busch, M., Cheung, C.K., Crnogorac, M., Delbarba, E., Eller, K., Faguer, S., Galesic, K., Griffin, Sian, Hoogen, M.W.F. van den, Hrušková, Z., Jeyabalan, A., Karras, A., King, C., Kohli, H.S., Mayer, G., Maas, R.J.H., Muto, M., Moiseev, S., Odler, B., Pepper, R.J., Quintana, L.F., Radhakrishnan, J., Ramachandran, R., Salama, A.D., Schönermarck, U., Segelmark, M., Smith, L., Tesař, V., Wetzels, J., Willcocks, L., Windpessl, M., Zand, L., Zonozi, R., and Kronbichler, A.
Abstract: Contains fulltext : 245229.pdf (Publisher’s version ) (Open Access), Membranous nephropathy (MN) is the most common cause of primary nephrotic syndrome among adults. The identification of phospholipase A2 receptor (PLA2R) as target antigen in most patients changed the management of MN dramatically, and provided a rationale for B-cell depleting agents such as rituximab. The efficacy of rituximab in inducing remission has been investigated in several studies, including 3 randomized controlled trials, in which complete and partial remission of proteinuria was achieved in approximately two-thirds of treated patients. Due to its favorable safety profile, rituximab is now considered a first-line treatment option for MN, especially in patients at moderate and high risk of deterioration in kidney function. However, questions remain about how to best use rituximab, including the optimal dosing regimen, a potential need for maintenance therapy, and assessment of long-term safety and efficacy outcomes. In this review, we provide an overview of the current literature and discuss both strengths and limitations of "the new standard."
Published: 2021

6. Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): a double-blind, randomised placebo-controlled trial

Author: Hernandez, A, Green, J, Janmohamed, S, D'Agostino, R, Granger, C, Jones, N, Leiter, L, Rosenberg, A, Sigmon, K, Somerville, M, Thorpe, K, Mcmurray, J, Del Prato, S, Califf, R, Holman, R, Demets, D, Riddle, M, Goodman, S, Mcguire, D, Alexander, K, Devore, A, Melloni, C, Patel, C, Kong, D, Bloomfield, G, Roe, M, Tricoci, P, Harrison, R, Lopes, R, Mathews, R, Mehta, R, Schuyler Jones, W, Vemulapalli, S, Povsic, T, Eapen, Z, Dombrowski, K, Kolls, B, Jordan, D, Ambrosy, A, Greene, S, Mandawat, A, Shavadia, J, Cooper, L, Sharma, A, Guimaraes, P, Friedman, D, Wilson, M, Endsley, P, Gentry, T, Collier, J, Perez, K, James, K, Roush, J, Pope, C, Howell, C, Johnson, M, Bailey, M, Cole, J, Akers, T, Vandyne, B, Thomas, B, Rich, J, Bartone, S, Beaulieu, G, Brown, K, Chau, T, Christian, T, Coker, R, Greene, D, Haddock, T, Jenkins, W, Haque, G, Marquess, M, Pesarchick, J, Rethaford, R, Stone, A, Al Kawas, F, Anderson, M, Enns, R, Sinay, I, Mathieu, C, Yordanov, V, Hramiak, I, Haluzik, M, Galatius, S, Guerci, B, Nauck, M, Migdalis, I, Tan, C, Kocsis, G, Giaccari, A, Lee, M, Munoz, E, Cornel, J, Birkeland, K, Pinto, M, Tirador, L, Olesinska-Mader, M, Shestakova, M, Distiller, L, Lopez-Sendon, J, Eliasson, B, Chiang, C, Srimahachota, S, Mankovsky, B, Bethel, M, Dungan, K, Kosiborod, M, Alvarisqueta, A, Baldovino, J, Besada, D, Calella, P, Cantero, M, Castano, P, Chertkoff, A, Cuadrado, J, De Loredo, L, Dominguez, A, Espanol, M, Finkelstein, H, Frechtel, G, Fretes, J, Garrido Santos, N, Gonzalez, J, Litvak, M, Loureyro, J, Maffei, L, Maldonado, N, Mohr Gasparini, D, Orio, S, Perez Manghi, F, Rodriguez Papini, N, Sala, J, Schygiel, P, Sposetti, G, Ulla, M, Verra, F, Zabalua, S, Zaidman, C, Crenier, L, Debroye, C, Duyck, F, Scheen, A, Van Gaal, L, Vercammen, C, Damyanova, V, Dimitrov, S, Kovacheva, S, Lozanov, L, Margaritov, V, Mihaylova-Shumkova, R, Nikolaeva, A, Stoyanova, Z, Akhras, R, Beaudry, Y, Bedard, J, Berlingieri, J, Chehayeb, R, Cheung, S, Conway, J, Cusson, J, Della Siega, A, Dumas, R, Dzongowski, P, Ferguson, M, Gaudet, D, Grondin, F, Gupta, A, Gupta, M, Halperin, F, Houle, P, Jones, M, Kouz, S, Kovacs, C, Landry, D, Lonn, E, O'Mahony, W, Peterson, S, Reich, D, Rosenbloom, A, St-Maurice, F, Tugwell, B, Vizel, S, Woo, V, Brychta, T, Cech, V, Dvorakova, E, Edelsberger, T, Halciakova, K, Krizova, J, Lastuvka, J, Piperek, M, Prymkova, V, Raclavska, L, Silhova, E, Urbanek, R, Vrkoc, J, Andersen, U, Bronnum-Schou, J, Hove, J, Jensen, J, Kober, L, Kristiansen, O, Lund, P, Melchior, T, Nyvad, O, Schou, M, Boye, A, Cadinot, D, Gouet, D, Henry, P, Kessler, L, Lalau, J, Petit, C, Thuan, J, Voinot, C, Vouillarmet, J, Axthelm, C, Berger, D, Bieler, T, Birkenfeld, A, Bott, J, Busch, K, Caca, K, Chevts, J, Donaubauer, T, Erlinger, R, Funke, K, Grosskopf, J, Hagenow, A, Hamann, M, Hartard, M, Heymer, P, Huppertz, W, Illies, G, Jacob, S, Jung, T, Kahrmann, G, Kast, P, Kellerer, M, Kempe, H, Khariouzov, A, Klausmann, G, Klein, C, Kleinecke-Pohl, U, Kleinertz, K, Koch, T, Kosch, C, Lorra, B, Luedemann, J, Luttermann, M, Maxeiner, S, Milek, K, Moelle, A, Neumann, G, Nischik, R, Oehrig-Pohl, E, Plassmann, G, Pohlmeier, L, Proepper, F, Regner, S, Rieker, W, Rose, L, Samer, H, Sauter, J, Schaper, F, Schiffer, C, Schmidt, J, Scholz, B, Schulze, J, Segner, A, Seufert, J, Sigal, H, Steindorf, J, Stockhausen, J, Stuebler, P, Taeschner, H, Tews, D, Tschoepe, D, Wilhelm, K, Zeller-Stefan, H, Avramidis, I, Bousboulas, S, Bristianou, M, Dimitriadis, G, Elisaf, M, Kotsa, K, Melidonis, A, Mitrakou, A, Pagkalos, E, Papanas, N, Pappas, A, Sampanis, C, Tentolouris, N, Tsapas, A, Tzatzagou, G, Ozaki, R, Hajdu, C, Harcsa, E, Konyves, L, Mucsi, J, Pauker, Z, Petro, G, Ples, Z, Revesz, K, Sandor, V, Vass, V, Avogaro, A, Boemi, M, Bonadonna, R, Consoli, A, De Cosmo, S, Di Bartolo, P, Dotta, F, Frontoni, S, Galetta, M, Gambineri, A, Gazzaruso, C, Giorgino, F, Lauro, D, Orsi, E, Paolisso, G, Perriello, G, Piatti, P, Pontiroli, A, Ponzani, P, Rivellese, A, Sesti, G, Tonolo, G, Trevisan, R, Ahn, C, Baik, S, Cha, B, Chung, C, Jang, H, Kim, C, Kim, H, Kim, I, Lee, E, Lee, H, Lee, K, Moon, K, Namgung, J, Park, K, Yoo, S, Yu, J, Llamas, E, Cervantes-Escarcega, J, Flota-Cervera, L, Gonzalez-Gonzalez, J, Pascoe-Gonzalez, S, Pelayo-Orozco, E, Ramirez-Diaz, S, Saldana-Mendoza, A, Jerjes-Diaz, C, Torres-Colores, J, Vidrio-Velazquez, M, Villagordoa-Mesa, J, Beijerbacht, H, Groutars, R, Hoek, B, Hoogslag, P, Kooy, A, Kragten, J, Lieverse, A, Swart, H, Viergever, E, Ahlqvist, J, Cooper, J, Gulseth, H, Guttormsen, G, Wium, C, Arbanil, H, Calderon, J, Camacho, L, Espinoza, A, Garrido, E, Luna, A, Manrique, H, Revoredo, F, Gonzales, R, Rincon, L, Zubiate, C, Ebo, G, Morales-Palomares, E, Arciszewska, M, Banach, M, Bijata-Bronisz, R, Derezinski, T, Gadzinski, W, Gajek, J, Klodawska, K, Krzyzagorska, E, Madej, A, Miekus, P, Opiela, J, Romanczuk, P, Siegel, A, Skokowska, E, Stankiewicz, A, Stasinska, T, Trznadel-Morawska, I, Witek, R, Aksentyev, S, Bondar, I, Demidova, I, Dreval, A, Ershova, O, Galstyan, G, Garganeeva, A, Izmozherova, N, Karetnikova, V, Kharakhulakh, M, Khokhlov, A, Kobalava, Z, Koshelskaya, O, Kosmacheva, E, Kostin, V, Koziolova, N, Kuzin, A, Lesnov, V, Lysenko, T, Markov, V, Mayorov, A, Moiseev, S, Myasoedova, S, Petunina, N, Rebrov, A, Ruyatkina, L, Samoylova, J, Sazonova, O, Shilkina, N, Sokolova, N, Vasilevskaya, O, Verbovaya, N, Vishneva, E, Vorobyev, S, Vorokhobina, N, Zanozina, O, Zhdanova, E, Zykova, T, Burgess, L, Coetzee, K, Dawood, S, Lombard, L, Makotoko, E, Moodley, R, Oosthuysen, W, Sarvan, M, Calvo Gomez, C, Cano Rodriguez, I, Castro Conde, A, Cequier Fillat, A, Cuatrecasas Cambra, G, de Alvaro Moreno, F, De Teresa Parreno, L, Delgado Lista, J, Dominguez Escribano, J, Duran Garcia, S, Elvira Gonzalez, J, Fernandez Rodriguez, J, Goday Arno, A, Gomez Huelgas, R, Gonzalez Juanatey, J, Hernandez Mijares, A, Jimenez Diaz, V, Jodar Gimeno, E, Lucas Morante, T, Marazuela, M, Martell Claros, N, Mauricio Puente, D, Mena Ribas, E, Merino Torres, J, Mezquita Raya, P, Nubiola Calonge, A, Ordonez Sanchez, X, Pascual Izuel, J, Perea Castilla, V, Perez Perez, A, Perez Soto, I, Quesada Charneco, M, Quesada Simon, A, Redon Mas, J, Rego Iraeta, A, Rodriguez Alvarez, M, Rodriguez Rodriguez, I, Saban Ruiz, J, Soto Gonzalez, A, Tinahones Madueno, F, Trescoli Serrano, C, Ulied Arminana, A, Bachus, E, Berndtsson Blom, K, Eliasson, K, Koskinen, P, Larnefeldt, H, Lif-Tiberg, C, Linderfalk, C, Lund, G, Lundman, P, Moris, L, Olsson, A, Salmonsson, S, Sanmartin Berglund, J, Sjoberg, F, Soderberg, S, Torstensson, I, Chen, J, Tien, K, Tseng, S, Tu, S, Wang, C, Wang, J, Phrommintikul, A, Yamwong, S, Jintapakorn, W, Hutayanon, P, Sansanayudh, N, Bazhan, L, Fushtey, I, Grachova, M, Katerenchuk, V, Korpachev, V, Kravchun, N, Larin, O, Mykhalchyshyn, G, Myshanych, H, Oleksyk, O, Orlenko, V, Pashkovska, N, Pertseva, N, Petrosyan, O, Smirnov, I, Vlasenko, M, Zlova, T, Aye, M, Baksi, A, Balasubramani, M, Beboso, R, Blagden, M, Bundy, C, Cookson, T, Copland, A, Emslie-Smith, A, Green, F, Gunstone, A, Issa, B, Jackson-Voyzey, E, Johnson, A, Maclean, M, Mcknight, J, Muzulu, S, O'Connell, I, Oyesile, B, Patterson, C, Pearson, E, Philip, S, Smith, P, Sukumaran, U, Abbas, J, Aggarwala, G, Akhter, F, Andersen, J, Anglade, M, Argoud, G, Ariani, M, Ashdji, R, Bakhtari, L, Banerjee, S, Bartlett, A, Baum, H, Bays, H, Beasley, R, Belfort de Aguiar, R, Benjamin, S, Bhagwat, R, Bhargava, A, Bode, B, Bratcher, C, Briskin, T, Brockmyre, A, Broughton, R, Brown, J, Budhraja, M, Cannon, K, Carr, J, Cathcart, H, Cavale, A, Chaykin, L, Cheung, D, Childress, R, Cohen, A, Condit, J, Cooksey, E, Cornett, G, Dauber, I, Davila, W, De Armas, L, Dean, J, Detweiler, R, Diaz, E, Di Giovanna, M, Dor, I, Drummond, W, Eagerton, D, Earl, J, Eaton, C, Ellison, H, Farris, N, Fiel, T, Firek, A, First, B, Forgosh, L, French, W, Gandy, W, Garcia, R, Gill, S, Gordon, M, Guice, M, Gummadi, S, Hackenyos, J, Hairston, K, Hanson, L, Harrison, L, Hartman, I, Heitner, J, Hejeebu, S, Hermany, P, Hernandez-Cassis, C, Hidalgo, H, Higgins, A, Ibrahim, H, Jacobs, S, Johnson, D, Joshi, P, Kaster, S, Kellum, D, Kim, E, Kirby, W, Knouse, A, Kulback, S, Kumar, M, Kuruvanka, T, Labroo, A, Lasswell, W, Lentz, J, Lenzmeier, T, Lewis, D, Li, Z, Lillestol, M, Little, R, Lorraine, R, McKeown-Biagas, C, Mcneill, R, Mehta, A, Miller, A, Moran, J, Morawski, E, Nadar, V, O'Connor, T, Odio, A, Parker, R, Patel, R, Phillips, L, Raad, G, Rahman, A, Raikhel, M, Raisinghani, A, Rajan, R, Rasouli, N, Rauzi, F, Rohr, K, Roseman, H, Rovner, S, Saba, F, Sachson, R, Schabauer, A, Schneider, R, Schuchard, T, Sensenbrenner, J, Shlesinger, Y, Singh, N, Sivalingam, K, Stonesifer, L, Storey, D, Suh, D, Tahir, M, Tan, A, Tan, M, Taylon, A, Thakkar, M, Tripathy, D, Uwaifo, G, Vedere, A, Venugopal, C, Vo, A, Welch, M, Welker, J, White, A, Willis, J, Wynne, A, Yazdani, S, Price, L, Lokhngina, Y, Xing, W, Overton, R, Stewart, M, Stead, J, Lindsay, A, Patel, V, Ross, J, Soffer, J, Daga, S, Sowell, M, Patel, P, Garvey, L, Ackert, J, Abraham, S, Sabol, M, Altobelli, D, Ha, J, Kulkarni, M, Noronha, D, Casson, E, Zang, E, Sandhu, C, Kumar, R, Chen, D, Taft, L, Ye, J, Shannon, J, Wilson, T, Babi, C, Miller, D, Russell, R, Bull, G, Hereghty, B, Fernandez-Salazar, E, Longley, T, Donaldson, J, Jarosz, M, Murphy, K, Adams, P, James, R, Richards, J, Sedani, S, Althouse, D, Watson, D, Lorimer, J, Lauder, S, Schultheis, R, Womer, T, Wraight, E, Li, W, Price-Olsen, E, Watson, A, Kelly, A, Mclaughlin, P, Fleming, J, Schubert, J, Schleiden, D, Harris, T, Prakash, R, Breneman, J, Deshpande, S, Saswadkar, A, Kumari, A, Shitut, A, Raorane, A, Karmalkar, A, Mhambrey, A, Bhosale, A, Vaphare, A, Patil, A, Khandelwal, C, Shaik, F, Nadar, M, Karka, M, Kadgaonkar, N, Gupta, N, Aher, N, Potnis, O, Naicker, P, Shinde, R, Sharma, R, Godse, R, Solanki, S, Sahu, S, Dumbre, S, Kumar, S, Patil, S, Mandal, T, Hernandez A. F., Green J. B., Janmohamed S., D'Agostino R. B., Granger C. B., Jones N. P., Leiter L. A., Rosenberg A. E., Sigmon K. N., Somerville M. C., Thorpe K. M., McMurray J. J. V., Del Prato S., Califf R. M., Holman R., DeMets D., Riddle M., Goodman S., McGuire D., Alexander K., Devore A., Melloni C., Patel C., Kong D., Bloomfield G., Roe M., Tricoci P., Harrison R., Lopes R., Mathews R., Mehta R., Schuyler Jones W., Vemulapalli S., Povsic T., Eapen Z., Dombrowski K., Kolls B., Jordan D., Ambrosy A., Greene S., Mandawat A., Shavadia J., Cooper L., Sharma A., Guimaraes P., Friedman D., Wilson M., Endsley P., Gentry T., Collier J., Perez K., James K., Roush J., Pope C., Howell C., Johnson M., Bailey M., Cole J., Akers T., Vandyne B., Thomas B., Rich J., Bartone S., Beaulieu G., Brown K., Chau T., Christian T., Coker R., Greene D., Haddock T., Jenkins W., Haque G., Marquess M., Pesarchick J., Rethaford R., Stone A., Al Kawas F., Anderson M., Enns R., Sinay I., Mathieu C., Yordanov V., Hramiak I., Haluzik M., Galatius S., Guerci B., Nauck M., Migdalis I., Tan C. B. K., Kocsis G., Giaccari A., Lee M. K., Munoz E. G. C., Cornel J., Birkeland K., Pinto M., Tirador L., Olesinska-Mader M., Shestakova M., Distiller L., Lopez-Sendon J., Eliasson B., Chiang C. -E., Srimahachota S., Mankovsky B., Bethel M. A., Dungan K., Kosiborod M., Alvarisqueta A., Baldovino J., Besada D., Calella P., Cantero M. C., Castano P., Chertkoff A., Cuadrado J., De Loredo L., Dominguez A., Espanol M. V., Finkelstein H., Frechtel G., Fretes J., Garrido Santos N., Gonzalez J., Litvak M., Loureyro J., Maffei L., Maldonado N., Mohr Gasparini D., Orio S., Perez Manghi F., Rodriguez Papini N., Sala J., Schygiel P., Sposetti G., Ulla M., Verra F., Zabalua S., Zaidman C., Crenier L., Debroye C., Duyck F., Scheen A., Van Gaal L., Vercammen C., Damyanova V., Dimitrov S., Kovacheva S., Lozanov L., Margaritov V., Mihaylova-Shumkova R., Nikolaeva A., Stoyanova Z., Akhras R., Beaudry Y., Bedard J., Berlingieri J., Chehayeb R., Cheung S., Conway J., Cusson J., Della Siega A., Dumas R., Dzongowski P., Ferguson M., Gaudet D., Grondin F., Gupta A., Gupta M., Halperin F., Houle P. -A., Jones M., Kouz S., Kovacs C., Landry D., Lonn E., O'Mahony W., Peterson S., Reich D., Rosenbloom A., St-Maurice F., Tugwell B., Vizel S., Woo V., Brychta T., Cech V., Dvorakova E., Edelsberger T., Halciakova K., Krizova J., Lastuvka J., Piperek M., Prymkova V., Raclavska L., Silhova E., Urbanek R., Vrkoc J., Andersen U., Bronnum-Schou J., Hove J., Jensen J. S., Kober L., Kristiansen O. P., Lund P., Melchior T., Nyvad O., Schou M., Boye A., Cadinot D., Gouet D., Henry P., Kessler L., Lalau J. -D., Petit C., Thuan J. -F., Voinot C., Vouillarmet J., Axthelm C., Berger D., Bieler T., Birkenfeld A., Bott J., Busch K., Caca K., Chevts J., Donaubauer T., Erlinger R., Funke K., Grosskopf J., Hagenow A., Hamann M., Hartard M., Heymer P., Huppertz W., Illies G., Jacob S., Jung T., Kahrmann G., Kast P., Kellerer M., Kempe H. -P., Khariouzov A., Klausmann G., Klein C., Kleinecke-Pohl U., Kleinertz K., Koch T., Kosch C., Lorra B., Luedemann J., Luttermann M., Maxeiner S., Milek K., Moelle A., Neumann G., Nischik R., Oehrig-Pohl E., Plassmann G., Pohlmeier L., Proepper F., Regner S., Rieker W., Rose L., Samer H., Sauter J., Schaper F., Schiffer C., Schmidt J., Scholz B. -M., Schulze J., Segner A., Seufert J., Sigal H., Steindorf J., Stockhausen J., Stuebler P., Taeschner H., Tews D., Tschoepe D., Wilhelm K., Zeller-Stefan H., Avramidis I., Bousboulas S., Bristianou M., Dimitriadis G., Elisaf M., Kotsa K., Melidonis A., Mitrakou A., Pagkalos E., Papanas N., Pappas A., Sampanis C., Tentolouris N., Tsapas A., Tzatzagou G., Ozaki R., Hajdu C., Harcsa E., Konyves L., Mucsi J., Pauker Z., Petro G., Ples Z., Revesz K., Sandor V., Vass V., Avogaro A., Boemi M., Bonadonna R., Consoli A., De Cosmo S., Di Bartolo P., Dotta F., Frontoni S., Galetta M., Gambineri A., Gazzaruso C., Giorgino F., Lauro D., Orsi E., Paolisso G., Perriello G., Piatti P., Pontiroli A., Ponzani P., Rivellese A. A., Sesti G., Tonolo G., Trevisan R., Ahn C. W., Baik S. -H., Cha B. -S., Chung C. -H., Jang H. C., Kim C. -J., Kim H. S., Kim I. J., Lee E. Y., Lee H. W., Lee K. -W., Moon K. -W., Namgung J., Park K. S., Yoo S. J., Yu J., Llamas E. -A. B., Cervantes-Escarcega J. -L., Flota-Cervera L. F., Gonzalez-Gonzalez J. G., Pascoe-Gonzalez S., Pelayo-Orozco E. S., Ramirez-Diaz S. -P., Saldana-Mendoza A., Jerjes-Diaz C. S., Torres-Colores J. J., Vidrio-Velazquez M., Villagordoa-Mesa J., Beijerbacht H. P., Groutars R. G. E. J., Hoek B. A., Hoogslag P. A. M., Kooy A., Kragten J. A., Lieverse A. G., Swart H. P., Viergever E. P., Ahlqvist J., Cooper J., Gulseth H., Guttormsen G., Wium C., Arbanil H., Calderon J., Camacho L., Espinoza A. D., Garrido E., Luna A., Manrique H., Revoredo F. M., Gonzales R. V., Rincon L. Z., Zubiate C., Ebo G., Morales-Palomares E., Arciszewska M., Banach M., Bijata-Bronisz R., Derezinski T., Gadzinski W., Gajek J., Klodawska K., Krzyzagorska E., Madej A., Miekus P., Opiela J., Romanczuk P., Siegel A., Skokowska E., Stankiewicz A., Stasinska T., Trznadel-Morawska I., Witek R., Aksentyev S., Bondar I., Demidova I., Dreval A., Ershova O., Galstyan G., Garganeeva A., Izmozherova N., Karetnikova V., Kharakhulakh M., Khokhlov A., Kobalava Z., Koshelskaya O., Kosmacheva E., Kostin V., Koziolova N., Kuzin A., Lesnov V., Lysenko T., Markov V., Mayorov A., Moiseev S., Myasoedova S., Petunina N., Rebrov A., Ruyatkina L., Samoylova J., Sazonova O., Shilkina N., Sokolova N., Vasilevskaya O., Verbovaya N., Vishneva E., Vorobyev S., Vorokhobina N., Zanozina O., Zhdanova E., Zykova T., Burgess L., Coetzee K., Dawood S., Lombard L., Makotoko E., Moodley R., Oosthuysen W., Sarvan M., Calvo Gomez C., Cano Rodriguez I., Castro Conde A., Cequier Fillat A., Cuatrecasas Cambra G., de Alvaro Moreno F., De Teresa Parreno L., Delgado Lista J., Dominguez Escribano J. R., Duran Garcia S., Elvira Gonzalez J., Fernandez Rodriguez J. M., Goday Arno A., Gomez Huelgas R., Gonzalez Juanatey J. R., Hernandez Mijares A., Jimenez Diaz V. A., Jodar Gimeno E., Lucas Morante T., Marazuela M., Martell Claros N., Mauricio Puente D., Mena Ribas E., Merino Torres J. F., Mezquita Raya P., Nubiola Calonge A., Ordonez Sanchez X., Pascual Izuel J. M., Perea Castilla V., Perez Perez A., Perez Soto I., Quesada Charneco M., Quesada Simon A., Redon Mas J., Rego Iraeta A., Rodriguez Alvarez M., Rodriguez Rodriguez I., Saban Ruiz J., Soto Gonzalez A., Tinahones Madueno F., Trescoli Serrano C., Ulied Arminana A., Bachus E., Berndtsson Blom K., Eliasson K., Koskinen P., Larnefeldt H., Lif-Tiberg C., Linderfalk C., Lund G., Lundman P., Moris L., Olsson A., Salmonsson S., Sanmartin Berglund J., Sjoberg F., Soderberg S., Torstensson I., Chen J. -F., Tien K. J., Tseng S. -T., Tu S. -T., Wang C. -Y., Wang J. -H., Phrommintikul A., Yamwong S., Jintapakorn W., Hutayanon P., Sansanayudh N., Bazhan L., Fushtey I., Grachova M., Katerenchuk V., Korpachev V., Kravchun N., Larin O., Mykhalchyshyn G., Myshanych H., Oleksyk O., Orlenko V., Pashkovska N., Pertseva N., Petrosyan O., Smirnov I., Vlasenko M., Zlova T., Aye M., Baksi A., Balasubramani M., Beboso R., Blagden M., Bundy C., Cookson T., Copland A., Emslie-Smith A., Green F., Gunstone A., Issa B., Jackson-Voyzey E., Johnson A., Maclean M., McKnight J., Muzulu S., O'Connell I., Oyesile B., Patterson C., Pearson E., Philip S., Smith P., Sukumaran U., Abbas J., Aggarwala G., Akhter F., Andersen J., Anglade M., Argoud G., Ariani M., Ashdji R., Bakhtari L., Banerjee S., Bartlett A., Baum H., Bays H., Beasley R., Belfort de Aguiar R., Benjamin S., Bhagwat R., Bhargava A., Bode B., Bratcher C., Briskin T., Brockmyre A., Broughton R., Brown J., Budhraja M., Cannon K., Carr J., Cathcart H., Cavale A., Chaykin L., Cheung D., Childress R., Cohen A., Condit J., Cooksey E., Cornett G. M., Dauber I., Davila W., De Armas L., Dean J., Detweiler R., Diaz E., Di Giovanna M., Dor I., Drummond W., Eagerton D., Earl J., Eaton C., Ellison H., Farris N., Fiel T., Firek A., First B., Forgosh L., French W., Gandy W., Garcia R., Gill S., Gordon M., Guice M., Gummadi S., Hackenyos J., Hairston K., Hanson L., Harrison L., Hartman I., Heitner J., Hejeebu S., Hermany P., Hernandez-Cassis C., Hidalgo H., Higgins A., Ibrahim H., Jacobs S., Johnson D., Joshi P., Kaster S., Kellum D., Kim C., Kim E., Kirby W., Knouse A., Kulback S., Kumar M., Kuruvanka T., Labroo A., Lasswell W., Lentz J., Lenzmeier T., Lewis D., Li Z., Lillestol M., Little R., Lorraine R., McKeown-Biagas C., McNeill R., Mehta A., Miller A., Moran J., Morawski E., Nadar V., O'Connor T., Odio A., Parker R., Patel R., Phillips L., Raad G., Rahman A., Raikhel M., Raisinghani A., Rajan R., Rasouli N., Rauzi F., Rohr K., Roseman H., Rovner S., Saba F., Sachson R., Schabauer A., Schneider R., Schuchard T., Sensenbrenner J., Shlesinger Y., Singh N., Sivalingam K., Stonesifer L., Storey D., Suh D., Tahir M., Tan A., Tan M., Taylon A., Thakkar M., Tripathy D., Uwaifo G., Vedere A., Venugopal C., Vo A., Welch M., Welker J., White A., Willis J., Wynne A., Yazdani S., Price L., Lokhngina Y., Xing W., Overton R., Stewart M., Stead J., Lindsay A., Patel V., Ross J., Soffer J., Daga S., Sowell M., Patel P., Garvey L., Ackert J., Abraham S., Sabol M. B., Altobelli D., Ha J., Kulkarni M., Noronha D., Casson E., Zang E., Sandhu C., Kumar R., Chen D., Taft L., Ye J., Shannon J., Wilson T., Babi C., Miller D., Russell R., Bull G., Hereghty B., Fernandez-Salazar E., Longley T., Donaldson J., Jarosz M., Murphy K., Adams P., James R., Richards J., Sedani S., Althouse D., Watson D., Lorimer J., Lauder S., Schultheis R., Womer T., Wraight E., Li W., Price-Olsen E., Watson A., Kelly A., McLaughlin P., Fleming J., Schubert J., Schleiden D., Harris T., Prakash R., Breneman J., Deshpande S., Saswadkar A., Kumari A., Shitut A., Raorane A., Karmalkar A., Mhambrey A., Bhosale A., Vaphare A., Patil A. P., Khandelwal C., Shaik F., Nadar M., Karka M., Kadgaonkar N., Gupta N., Aher N., Potnis O., Naicker P., Shinde R., Sharma R., Godse R., Solanki S., Sahu S., Dumbre S., Kumar S., Patil S., Mandal T., Hernandez, A, Green, J, Janmohamed, S, D'Agostino, R, Granger, C, Jones, N, Leiter, L, Rosenberg, A, Sigmon, K, Somerville, M, Thorpe, K, Mcmurray, J, Del Prato, S, Califf, R, Holman, R, Demets, D, Riddle, M, Goodman, S, Mcguire, D, Alexander, K, Devore, A, Melloni, C, Patel, C, Kong, D, Bloomfield, G, Roe, M, Tricoci, P, Harrison, R, Lopes, R, Mathews, R, Mehta, R, Schuyler Jones, W, Vemulapalli, S, Povsic, T, Eapen, Z, Dombrowski, K, Kolls, B, Jordan, D, Ambrosy, A, Greene, S, Mandawat, A, Shavadia, J, Cooper, L, Sharma, A, Guimaraes, P, Friedman, D, Wilson, M, Endsley, P, Gentry, T, Collier, J, Perez, K, James, K, Roush, J, Pope, C, Howell, C, Johnson, M, Bailey, M, Cole, J, Akers, T, Vandyne, B, Thomas, B, Rich, J, Bartone, S, Beaulieu, G, Brown, K, Chau, T, Christian, T, Coker, R, Greene, D, Haddock, T, Jenkins, W, Haque, G, Marquess, M, Pesarchick, J, Rethaford, R, Stone, A, Al Kawas, F, Anderson, M, Enns, R, Sinay, I, Mathieu, C, Yordanov, V, Hramiak, I, Haluzik, M, Galatius, S, Guerci, B, Nauck, M, Migdalis, I, Tan, C, Kocsis, G, Giaccari, A, Lee, M, Munoz, E, Cornel, J, Birkeland, K, Pinto, M, Tirador, L, Olesinska-Mader, M, Shestakova, M, Distiller, L, Lopez-Sendon, J, Eliasson, B, Chiang, C, Srimahachota, S, Mankovsky, B, Bethel, M, Dungan, K, Kosiborod, M, Alvarisqueta, A, Baldovino, J, Besada, D, Calella, P, Cantero, M, Castano, P, Chertkoff, A, Cuadrado, J, De Loredo, L, Dominguez, A, Espanol, M, Finkelstein, H, Frechtel, G, Fretes, J, Garrido Santos, N, Gonzalez, J, Litvak, M, Loureyro, J, Maffei, L, Maldonado, N, Mohr Gasparini, D, Orio, S, Perez Manghi, F, Rodriguez Papini, N, Sala, J, Schygiel, P, Sposetti, G, Ulla, M, Verra, F, Zabalua, S, Zaidman, C, Crenier, L, Debroye, C, Duyck, F, Scheen, A, Van Gaal, L, Vercammen, C, Damyanova, V, Dimitrov, S, Kovacheva, S, Lozanov, L, Margaritov, V, Mihaylova-Shumkova, R, Nikolaeva, A, Stoyanova, Z, Akhras, R, Beaudry, Y, Bedard, J, Berlingieri, J, Chehayeb, R, Cheung, S, Conway, J, Cusson, J, Della Siega, A, Dumas, R, Dzongowski, P, Ferguson, M, Gaudet, D, Grondin, F, Gupta, A, Gupta, M, Halperin, F, Houle, P, Jones, M, Kouz, S, Kovacs, C, Landry, D, Lonn, E, O'Mahony, W, Peterson, S, Reich, D, Rosenbloom, A, St-Maurice, F, Tugwell, B, Vizel, S, Woo, V, Brychta, T, Cech, V, Dvorakova, E, Edelsberger, T, Halciakova, K, Krizova, J, Lastuvka, J, Piperek, M, Prymkova, V, Raclavska, L, Silhova, E, Urbanek, R, Vrkoc, J, Andersen, U, Bronnum-Schou, J, Hove, J, Jensen, J, Kober, L, Kristiansen, O, Lund, P, Melchior, T, Nyvad, O, Schou, M, Boye, A, Cadinot, D, Gouet, D, Henry, P, Kessler, L, Lalau, J, Petit, C, Thuan, J, Voinot, C, Vouillarmet, J, Axthelm, C, Berger, D, Bieler, T, Birkenfeld, A, Bott, J, Busch, K, Caca, K, Chevts, J, Donaubauer, T, Erlinger, R, Funke, K, Grosskopf, J, Hagenow, A, Hamann, M, Hartard, M, Heymer, P, Huppertz, W, Illies, G, Jacob, S, Jung, T, Kahrmann, G, Kast, P, Kellerer, M, Kempe, H, Khariouzov, A, Klausmann, G, Klein, C, Kleinecke-Pohl, U, Kleinertz, K, Koch, T, Kosch, C, Lorra, B, Luedemann, J, Luttermann, M, Maxeiner, S, Milek, K, Moelle, A, Neumann, G, Nischik, R, Oehrig-Pohl, E, Plassmann, G, Pohlmeier, L, Proepper, F, Regner, S, Rieker, W, Rose, L, Samer, H, Sauter, J, Schaper, F, Schiffer, C, Schmidt, J, Scholz, B, Schulze, J, Segner, A, Seufert, J, Sigal, H, Steindorf, J, Stockhausen, J, Stuebler, P, Taeschner, H, Tews, D, Tschoepe, D, Wilhelm, K, Zeller-Stefan, H, Avramidis, I, Bousboulas, S, Bristianou, M, Dimitriadis, G, Elisaf, M, Kotsa, K, Melidonis, A, Mitrakou, A, Pagkalos, E, Papanas, N, Pappas, A, Sampanis, C, Tentolouris, N, Tsapas, A, Tzatzagou, G, Ozaki, R, Hajdu, C, Harcsa, E, Konyves, L, Mucsi, J, Pauker, Z, Petro, G, Ples, Z, Revesz, K, Sandor, V, Vass, V, Avogaro, A, Boemi, M, Bonadonna, R, Consoli, A, De Cosmo, S, Di Bartolo, P, Dotta, F, Frontoni, S, Galetta, M, Gambineri, A, Gazzaruso, C, Giorgino, F, Lauro, D, Orsi, E, Paolisso, G, Perriello, G, Piatti, P, Pontiroli, A, Ponzani, P, Rivellese, A, Sesti, G, Tonolo, G, Trevisan, R, Ahn, C, Baik, S, Cha, B, Chung, C, Jang, H, Kim, C, Kim, H, Kim, I, Lee, E, Lee, H, Lee, K, Moon, K, Namgung, J, Park, K, Yoo, S, Yu, J, Llamas, E, Cervantes-Escarcega, J, Flota-Cervera, L, Gonzalez-Gonzalez, J, Pascoe-Gonzalez, S, Pelayo-Orozco, E, Ramirez-Diaz, S, Saldana-Mendoza, A, Jerjes-Diaz, C, Torres-Colores, J, Vidrio-Velazquez, M, Villagordoa-Mesa, J, Beijerbacht, H, Groutars, R, Hoek, B, Hoogslag, P, Kooy, A, Kragten, J, Lieverse, A, Swart, H, Viergever, E, Ahlqvist, J, Cooper, J, Gulseth, H, Guttormsen, G, Wium, C, Arbanil, H, Calderon, J, Camacho, L, Espinoza, A, Garrido, E, Luna, A, Manrique, H, Revoredo, F, Gonzales, R, Rincon, L, Zubiate, C, Ebo, G, Morales-Palomares, E, Arciszewska, M, Banach, M, Bijata-Bronisz, R, Derezinski, T, Gadzinski, W, Gajek, J, Klodawska, K, Krzyzagorska, E, Madej, A, Miekus, P, Opiela, J, Romanczuk, P, Siegel, A, Skokowska, E, Stankiewicz, A, Stasinska, T, Trznadel-Morawska, I, Witek, R, Aksentyev, S, Bondar, I, Demidova, I, Dreval, A, Ershova, O, Galstyan, G, Garganeeva, A, Izmozherova, N, Karetnikova, V, Kharakhulakh, M, Khokhlov, A, Kobalava, Z, Koshelskaya, O, Kosmacheva, E, Kostin, V, Koziolova, N, Kuzin, A, Lesnov, V, Lysenko, T, Markov, V, Mayorov, A, Moiseev, S, Myasoedova, S, Petunina, N, Rebrov, A, Ruyatkina, L, Samoylova, J, Sazonova, O, Shilkina, N, Sokolova, N, Vasilevskaya, O, Verbovaya, N, Vishneva, E, Vorobyev, S, Vorokhobina, N, Zanozina, O, Zhdanova, E, Zykova, T, Burgess, L, Coetzee, K, Dawood, S, Lombard, L, Makotoko, E, Moodley, R, Oosthuysen, W, Sarvan, M, Calvo Gomez, C, Cano Rodriguez, I, Castro Conde, A, Cequier Fillat, A, Cuatrecasas Cambra, G, de Alvaro Moreno, F, De Teresa Parreno, L, Delgado Lista, J, Dominguez Escribano, J, Duran Garcia, S, Elvira Gonzalez, J, Fernandez 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V., Finkelstein H., Frechtel G., Fretes J., Garrido Santos N., Gonzalez J., Litvak M., Loureyro J., Maffei L., Maldonado N., Mohr Gasparini D., Orio S., Perez Manghi F., Rodriguez Papini N., Sala J., Schygiel P., Sposetti G., Ulla M., Verra F., Zabalua S., Zaidman C., Crenier L., Debroye C., Duyck F., Scheen A., Van Gaal L., Vercammen C., Damyanova V., Dimitrov S., Kovacheva S., Lozanov L., Margaritov V., Mihaylova-Shumkova R., Nikolaeva A., Stoyanova Z., Akhras R., Beaudry Y., Bedard J., Berlingieri J., Chehayeb R., Cheung S., Conway J., Cusson J., Della Siega A., Dumas R., Dzongowski P., Ferguson M., Gaudet D., Grondin F., Gupta A., Gupta M., Halperin F., Houle P. -A., Jones M., Kouz S., Kovacs C., Landry D., Lonn E., O'Mahony W., Peterson S., Reich D., Rosenbloom A., St-Maurice F., Tugwell B., Vizel S., Woo V., Brychta T., Cech V., Dvorakova E., Edelsberger T., Halciakova K., Krizova J., Lastuvka J., Piperek M., Prymkova V., Raclavska L., Silhova E., Urbanek R., Vrkoc J., Andersen U., Bronnum-Schou J., Hove J., Jensen J. 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A., Sesti G., Tonolo G., Trevisan R., Ahn C. W., Baik S. -H., Cha B. -S., Chung C. -H., Jang H. C., Kim C. -J., Kim H. S., Kim I. J., Lee E. Y., Lee H. W., Lee K. -W., Moon K. -W., Namgung J., Park K. S., Yoo S. J., Yu J., Llamas E. -A. B., Cervantes-Escarcega J. -L., Flota-Cervera L. F., Gonzalez-Gonzalez J. G., Pascoe-Gonzalez S., Pelayo-Orozco E. S., Ramirez-Diaz S. -P., Saldana-Mendoza A., Jerjes-Diaz C. S., Torres-Colores J. J., Vidrio-Velazquez M., Villagordoa-Mesa J., Beijerbacht H. P., Groutars R. G. E. J., Hoek B. A., Hoogslag P. A. M., Kooy A., Kragten J. A., Lieverse A. G., Swart H. P., Viergever E. P., Ahlqvist J., Cooper J., Gulseth H., Guttormsen G., Wium C., Arbanil H., Calderon J., Camacho L., Espinoza A. D., Garrido E., Luna A., Manrique H., Revoredo F. M., Gonzales R. V., Rincon L. 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R., Duran Garcia S., Elvira Gonzalez J., Fernandez Rodriguez J. M., Goday Arno A., Gomez Huelgas R., Gonzalez Juanatey J. R., Hernandez Mijares A., Jimenez Diaz V. A., Jodar Gimeno E., Lucas Morante T., Marazuela M., Martell Claros N., Mauricio Puente D., Mena Ribas E., Merino Torres J. F., Mezquita Raya P., Nubiola Calonge A., Ordonez Sanchez X., Pascual Izuel J. M., Perea Castilla V., Perez Perez A., Perez Soto I., Quesada Charneco M., Quesada Simon A., Redon Mas J., Rego Iraeta A., Rodriguez Alvarez M., Rodriguez Rodriguez I., Saban Ruiz J., Soto Gonzalez A., Tinahones Madueno F., Trescoli Serrano C., Ulied Arminana A., Bachus E., Berndtsson Blom K., Eliasson K., Koskinen P., Larnefeldt H., Lif-Tiberg C., Linderfalk C., Lund G., Lundman P., Moris L., Olsson A., Salmonsson S., Sanmartin Berglund J., Sjoberg F., Soderberg S., Torstensson I., Chen J. -F., Tien K. 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B., Altobelli D., Ha J., Kulkarni M., Noronha D., Casson E., Zang E., Sandhu C., Kumar R., Chen D., Taft L., Ye J., Shannon J., Wilson T., Babi C., Miller D., Russell R., Bull G., Hereghty B., Fernandez-Salazar E., Longley T., Donaldson J., Jarosz M., Murphy K., Adams P., James R., Richards J., Sedani S., Althouse D., Watson D., Lorimer J., Lauder S., Schultheis R., Womer T., Wraight E., Li W., Price-Olsen E., Watson A., Kelly A., McLaughlin P., Fleming J., Schubert J., Schleiden D., Harris T., Prakash R., Breneman J., Deshpande S., Saswadkar A., Kumari A., Shitut A., Raorane A., Karmalkar A., Mhambrey A., Bhosale A., Vaphare A., Patil A. P., Khandelwal C., Shaik F., Nadar M., Karka M., Kadgaonkar N., Gupta N., Aher N., Potnis O., Naicker P., Shinde R., Sharma R., Godse R., Solanki S., Sahu S., Dumbre S., Kumar S., Patil S., and Mandal T.
Abstract: Background: Glucagon-like peptide 1 receptor agonists differ in chemical structure, duration of action, and in their effects on clinical outcomes. The cardiovascular effects of once-weekly albiglutide in type 2 diabetes are unknown. We aimed to determine the safety and efficacy of albiglutide in preventing cardiovascular death, myocardial infarction, or stroke. Methods: We did a double-blind, randomised, placebo-controlled trial in 610 sites across 28 countries. We randomly assigned patients aged 40 years and older with type 2 diabetes and cardiovascular disease (at a 1:1 ratio) to groups that either received a subcutaneous injection of albiglutide (30–50 mg, based on glycaemic response and tolerability) or of a matched volume of placebo once a week, in addition to their standard care. Investigators used an interactive voice or web response system to obtain treatment assignment, and patients and all study investigators were masked to their treatment allocation. We hypothesised that albiglutide would be non-inferior to placebo for the primary outcome of the first occurrence of cardiovascular death, myocardial infarction, or stroke, which was assessed in the intention-to-treat population. If non-inferiority was confirmed by an upper limit of the 95% CI for a hazard ratio of less than 1·30, closed testing for superiority was prespecified. This study is registered with ClinicalTrials.gov, number NCT02465515. Findings: Patients were screened between July 1, 2015, and Nov 24, 2016. 10 793 patients were screened and 9463 participants were enrolled and randomly assigned to groups: 4731 patients were assigned to receive albiglutide and 4732 patients to receive placebo. On Nov 8, 2017, it was determined that 611 primary endpoints and a median follow-up of at least 1·5 years had accrued, and participants returned for a final visit and discontinuation from study treatment; the last patient visit was on March 12, 2018. These 9463 patients, the intention-to-treat population, were
Published: 2018

7. International Consensus on ANCA Testing in Eosinophilic Granulomatosis with Polyangiitis

Author: Moiseev, S, Bossuyt, X, Arimura, Y, Blockmans, D, Csernok, E, Damoiseaux, J, Emmi, G, Flores-Suárez, L, Hellmich, B, Jayne, D, Jennette, J, Little, M, Mohammad, A, Moosig, F, Novikov, P, Pagnoux, C, Radice, A, Sada, K, Segelmark, M, Shoenfeld, Y, Sinico, R, Specks, U, Terrier, B, Tzioufas, A, Vaglio, A, Zhao, M, Cohen Tervaert, J, Moiseev, Sergey, Bossuyt, Xavier, Arimura, Yoshihiro, Blockmans, Daniel, Csernok, Elena, Damoiseaux, Jan, Emmi, Giacomo, Flores-Suárez, Luis Felipe, Hellmich, Bernhard, Jayne, David, Jennette, J Charles, Little, Mark A, Mohammad, Aladdin J, Moosig, Frank, Novikov, Pavel, Pagnoux, Christian, Radice, Antonella, Sada, Ken-Ei, Segelmark, Mårten, Shoenfeld, Yehuda, Sinico, Renato A, Specks, Ulrich, Terrier, Benjamin, Tzioufas, Athanasios G, Vaglio, Augusto, Zhao, Ming-Hui, Cohen Tervaert, Jan Willem, Moiseev, S, Bossuyt, X, Arimura, Y, Blockmans, D, Csernok, E, Damoiseaux, J, Emmi, G, Flores-Suárez, L, Hellmich, B, Jayne, D, Jennette, J, Little, M, Mohammad, A, Moosig, F, Novikov, P, Pagnoux, C, Radice, A, Sada, K, Segelmark, M, Shoenfeld, Y, Sinico, R, Specks, U, Terrier, B, Tzioufas, A, Vaglio, A, Zhao, M, Cohen Tervaert, J, Moiseev, Sergey, Bossuyt, Xavier, Arimura, Yoshihiro, Blockmans, Daniel, Csernok, Elena, Damoiseaux, Jan, Emmi, Giacomo, Flores-Suárez, Luis Felipe, Hellmich, Bernhard, Jayne, David, Jennette, J Charles, Little, Mark A, Mohammad, Aladdin J, Moosig, Frank, Novikov, Pavel, Pagnoux, Christian, Radice, Antonella, Sada, Ken-Ei, Segelmark, Mårten, Shoenfeld, Yehuda, Sinico, Renato A, Specks, Ulrich, Terrier, Benjamin, Tzioufas, Athanasios G, Vaglio, Augusto, Zhao, Ming-Hui, and Cohen Tervaert, Jan Willem
Abstract: An international consensus on anti-neutrophil cytoplasm antibodies (ANCA) testing in eosinophilic granulomatosis with polyangiitis (EGPA) is presented. ANCA, specific for myeloperoxidase (MPO), can be detected in 30-35% of EGPA patients. MPO-ANCA should be tested with antigen-specific immunoassays in any patient with eosinophilic asthma and clinical features suggesting EGPA, including constitutional symptoms, purpura, polyneuropathy, unexplained heart, gastrointestinal or kidney disease, and/or pulmonary infiltrates or hemorrhage. A positive MPO-ANCA result contributes to the diagnostic work‐up for EGPA. Patients with MPO-ANCA associated EGPA have more frequently vasculitis features, such as glomerulonephritis, neuropathy, and skin manifestations than patients with ANCA negative EGPA. However, the presence of MPO-ANCA is neither sensitive nor specific enough to identify whether a patient should be subclassified as having "vasculitic" or "eosinophilic" EGPA. At present, ANCA status cannot guide treatment decisions, that is, whether cyclophosphamide, rituximab or mepolizumab should be added to conventional glucocorticoid treatment. In EGPA, monitoring of ANCA is only useful when MPO-ANCA was tested positive at disease onset.
Published: 2020

8. 2020 international consensus on ANCA testing beyond systemic vasculitis

Author: Moiseev, S, Tervaert, J, Arimura, Y, Bogdanos, D, Csernok, E, Damoiseaux, J, Ferrante, M, Flores-Suárez, L, Fritzler, M, Invernizzi, P, Jayne, D, Jennette, J, Little, M, Mcadoo, S, Novikov, P, Pusey, C, Radice, A, Salama, A, Savige, J, Segelmark, M, Shoenfeld, Y, Sinico, R, Sousa, M, Specks, U, Terrier, B, Tzioufas, A, Vermeire, S, Zhao, M, Bossuyt, X, Moiseev, Sergey, Tervaert, Jan Willem Cohen, Arimura, Yoshihiro, Bogdanos, Dimitrios P., Csernok, Elena, Damoiseaux, Jan, Ferrante, Marc, Flores-Suárez, Luis Felipe, Fritzler, Marvin J., Invernizzi, Pietro, Jayne, David, Jennette, J. Charles, Little, Mark, McAdoo, Stephen P., Novikov, Pavel, Pusey, Charles D., Radice, Antonella, Salama, Alan D., Savige, Judith A., Segelmark, Mårten, Shoenfeld, Yehuda, Sinico, Renato A., Sousa, Maria-José, Specks, Ulrich, Terrier, Benjamin, Tzioufas, Athanasios G., Vermeire, Severine, Zhao, Ming-Hui, Bossuyt, Xavier, Moiseev, S, Tervaert, J, Arimura, Y, Bogdanos, D, Csernok, E, Damoiseaux, J, Ferrante, M, Flores-Suárez, L, Fritzler, M, Invernizzi, P, Jayne, D, Jennette, J, Little, M, Mcadoo, S, Novikov, P, Pusey, C, Radice, A, Salama, A, Savige, J, Segelmark, M, Shoenfeld, Y, Sinico, R, Sousa, M, Specks, U, Terrier, B, Tzioufas, A, Vermeire, S, Zhao, M, Bossuyt, X, Moiseev, Sergey, Tervaert, Jan Willem Cohen, Arimura, Yoshihiro, Bogdanos, Dimitrios P., Csernok, Elena, Damoiseaux, Jan, Ferrante, Marc, Flores-Suárez, Luis Felipe, Fritzler, Marvin J., Invernizzi, Pietro, Jayne, David, Jennette, J. Charles, Little, Mark, McAdoo, Stephen P., Novikov, Pavel, Pusey, Charles D., Radice, Antonella, Salama, Alan D., Savige, Judith A., Segelmark, Mårten, Shoenfeld, Yehuda, Sinico, Renato A., Sousa, Maria-José, Specks, Ulrich, Terrier, Benjamin, Tzioufas, Athanasios G., Vermeire, Severine, Zhao, Ming-Hui, and Bossuyt, Xavier
Abstract: This document follows up on a 2017 revised international consensus on anti-neutrophil cytoplasm antibodies (ANCA) testing in granulomatosis with polyangiitis and microscopic polyangiitis and focuses on the clinical and diagnostic value of ANCA detection in patients with connective tissue diseases, idiopathic interstitial pneumonia, autoimmune liver diseases, inflammatory bowel diseases, anti-glomerular basement membrane (GBM) disease, infections, malignancy, and during drug treatment. Current evidence suggests that in certain settings beyond systemic vasculitis, ANCA may have clinical, pathogenic and/or diagnostic relevance. Antigen-specific ANCA targeting proteinase-3 and myeloperoxidase should be tested by solid phase immunoassays in any patient with clinical features suggesting ANCA-associated vasculitis and in all patients with anti-GBM disease, idiopathic interstitial pneumonia, and infective endocarditis associated with nephritis, whereas in patients with other aforementioned disorders routine ANCA testing is not recommended. Among patients with autoimmune liver diseases or inflammatory bowel diseases, ANCA testing may be justified in patients with suspected autoimmune hepatitis type 1 who do not have conventional autoantibodies or in case of diagnostic uncertainty to discriminate ulcerative colitis from Crohn's disease. In these cases, ANCA should be tested by indirect immunofluorescence as the target antigens are not yet well characterized. Many questions concerning the optimal use of ANCA testing in patients without ANCA-associated vasculitis remain to be answered.
Published: 2020

9. AB0511 International Consensus on ANCA Testing and Interpretation Beyond Systemic Vasculitis

Author: Moiseev, S, Cohen Tervaert, J, Arimura, Y, Bogdanos, D, Elena, C, Damoiseaux, J, Ferrante, M, Flores-Suárez, L, Fritzler, M, Invernizzi, P, Jayne, D, Jennette, J, Little, M, Mcadoo, S, Novikov, P, Pusey, C, Radice, A, Salama, A, Savige, J, Segelmark, M, Shoenfeld, Y, Sinico, R, De Sousa, M, Specks, U, Terrier, B, Tzioufas, A, Vermeire, S, Zhao, M, Bossuyt, X, S Moiseev, JW Cohen Tervaert, Y Arimura, D Bogdanos, C Elena, J Damoiseaux, M Ferrante, LF Flores-Suárez, M Fritzler, P Invernizzi, D Jayne, JC Jennette, M Little, SP Mcadoo, P Novikov, CD Pusey, A Radice, AD Salama, J Savige, M Segelmark, Y Shoenfeld, RA Sinico, MJR De Sousa, U Specks, B Terrier, A Tzioufas, S Vermeire, MH Zhao, X Bossuyt, Moiseev, S, Cohen Tervaert, J, Arimura, Y, Bogdanos, D, Elena, C, Damoiseaux, J, Ferrante, M, Flores-Suárez, L, Fritzler, M, Invernizzi, P, Jayne, D, Jennette, J, Little, M, Mcadoo, S, Novikov, P, Pusey, C, Radice, A, Salama, A, Savige, J, Segelmark, M, Shoenfeld, Y, Sinico, R, De Sousa, M, Specks, U, Terrier, B, Tzioufas, A, Vermeire, S, Zhao, M, Bossuyt, X, S Moiseev, JW Cohen Tervaert, Y Arimura, D Bogdanos, C Elena, J Damoiseaux, M Ferrante, LF Flores-Suárez, M Fritzler, P Invernizzi, D Jayne, JC Jennette, M Little, SP Mcadoo, P Novikov, CD Pusey, A Radice, AD Salama, J Savige, M Segelmark, Y Shoenfeld, RA Sinico, MJR De Sousa, U Specks, B Terrier, A Tzioufas, S Vermeire, MH Zhao, and X Bossuyt
Abstract: Background: ANCA can be detected in sera from patients with autoimmune, inflammatory, infectious or neoplastic diseases. Objectives: To issue a Consensus Statement on ANCA testing and interpretation beyond systemic vasculitis. Methods: This Statement was prepared by a group of experts, based on the results of a comprehensive search in PubMed. Results: In certain settings beyond systemic vasculitis, ANCA may have diagnostic, clinical, and/or prognostic relevance. Testing for PR3- and MPO-ANCA by specific immunoassays should be performed in any patient with clinical features suggesting ANCA-associated vasculitis and in patients with anti-GBM disease and idiopathic interstitial pneumonia. Routine ANCA testing is not recommended in patients with connective tissue diseases (CTD), autoimmune liver diseases, inflammatory bowel diseases, infections, and/or malignancy unless there is evidence for small vessel vasculitis. ANCA testing by specific immunoassays may be useful in patients with rheumatoid arthritis, systemic sclerosis or primary Sjögren’s syndrome who have kidney disease with a nephritic sediment or in patients with systemic lupus erythematosus if a kidney biopsy shows prominent necrotizing and crescentic lesions or proliferative lupus nephritis. ANCA testing may be justified in patients with suspected autoimmune hepatitis type 1, who do not have conventional disease-related autoantibodies, or in patients with inflammatory bowel diseases in case of diagnostic uncertainty to discriminate ulcerative colitis from Crohn’s disease. In these cases, ANCA should be tested by indirect immunofluorescence since target antigens are not well characterized. ANCA against bactericidal/permeability-increasing protein may be a biomarker for deteriorating lung function and a poor prognosis in patients with cystic fibrosis. Conclusion: ANCA testing is clinically relevant not only in patients with manifestations suggesting systemic vasculitis, but also in patients with certain other
Published: 2020

10. Nintedanib in patients with progressive fibrosing interstitial lung diseases—subgroup analyses by interstitial lung disease diagnosis in the INBUILD trial: a randomised, double-blind, placebo-controlled, parallel-group trial

Author: Wells, A. U., Flaherty, K. R., Brown, K. K., Inoue, Y., Devaraj, A., Richeldi, Luca, Moua, T., Crestani, B., Wuyts, W. A., Stowasser, S., Quaresma, M., Goeldner, R. -G., Schlenker-Herceg, R., Kolb, M., Abe, S., Aburto, M., Acosta, O., Andrews, C., Antin-Ozerkis, D., Arce, G., Arias, M., Avdeev, S., Barczyk, A., Bascom, R., Bazdyrev, E., Beirne, P., Belloli, E., Bergna, M. A., Bergot, E., Bhatt, N., Blaas, S., Bondue, B., Bonella, F., Britt, E., Buch, K., Burk, J., Cai, H., Cantin, A., Castillo Villegas, D. M., Cazaux, A., Cerri, S., Chaaban, S., Chaudhuri, N., Cottin, V., Criner, G., Dahlqvist, C., Danoff, S., Dematte D'Amico, J., Dilling, D., Elias, P., Ettinger, N., Falk, J., Fernandez Perez, E. R., Gamez-Dubuis, A., Giessel, G., Gifford, A., Glassberg, M., Glazer, C., Golden, J., Gomez Carrera, L., Guiot, J., Hallowell, R., Hayashi, H., Hetzel, J., Hirani, N., Homik, L., Hope-Gill, B., Hotchkin, D., Ichikado, K., Ilkovich, M., Izumi, S., Jassem, E., Jones, L., Jouneau, S., Kaner, R., Kang, J., Kawamura, T., Kessler, R., Kim, Y., Kishi, K., Kitamura, H., Kondoh, Y., Kono, C., Koschel, D., Kreuter, M., Kulkarni, T., Kus, J., Lebargy, F., Leon Jimenez, A., Luo, Q., Mageto, Y., Maher, T. M., Makino, S., Marchand-Adam, S., Marquette, C., Martinez, Sara, Martinez, M., Maturana Rozas, R., Miyazaki, Y., Moiseev, S., Molina-Molina, M., Malcolm, Joan Morrison, Morrow, L., Nambiar, A., Nishioka, Y., Nunes, H., Okamoto, M., Oldham, J., Otaola, M., Padilla, M., Park, J. S., Patel, N., Pesci, Riccardo, Piotrowski, W., Pitts, L., Poonyagariyagorn, H., Prasse, A., Quadrelli, S., Randerath, W., Refini, R., Reynaud-Gaubert, M., Riviere, F., Rodriguez Portal, J. A., Rosas, I., Rossman, M., Safdar, Z., Saito, T., Sakamoto, N., Salinas Fenero, M., Sauleda, J., Schmidt, S., Scholand, M. B., Schwartz, M., Shapera, S., Shlobin, O., Sigal, B., Silva Orellana, A., Skowasch, D., Song, J. W., Stieglitz, S., Stone, H., Strek, M., Suda, T., Sugiura, H., Takahashi, H., Takaya, H., Takeuchi, T., Thavarajah, K., Tolle, L., Tomassetti, S., Tomii, K., Valenzuela, C., Vancheri, C., Varone, Francesco, Veeraraghavan, S., Villar, A., Weigt, S., Wemeau, L., Wuyts, W., Xu, Z., Yakusevich, V., Yamada, Y., Yamauchi, H., Ziora, D., Richeldi L. (ORCID:0000-0001-8594-1448), Martinez R., Morrison L., Pesci A., Varone F., Wells, A. U., Flaherty, K. R., Brown, K. K., Inoue, Y., Devaraj, A., Richeldi, Luca, Moua, T., Crestani, B., Wuyts, W. A., Stowasser, S., Quaresma, M., Goeldner, R. -G., Schlenker-Herceg, R., Kolb, M., Abe, S., Aburto, M., Acosta, O., Andrews, C., Antin-Ozerkis, D., Arce, G., Arias, M., Avdeev, S., Barczyk, A., Bascom, R., Bazdyrev, E., Beirne, P., Belloli, E., Bergna, M. A., Bergot, E., Bhatt, N., Blaas, S., Bondue, B., Bonella, F., Britt, E., Buch, K., Burk, J., Cai, H., Cantin, A., Castillo Villegas, D. M., Cazaux, A., Cerri, S., Chaaban, S., Chaudhuri, N., Cottin, V., Criner, G., Dahlqvist, C., Danoff, S., Dematte D'Amico, J., Dilling, D., Elias, P., Ettinger, N., Falk, J., Fernandez Perez, E. R., Gamez-Dubuis, A., Giessel, G., Gifford, A., Glassberg, M., Glazer, C., Golden, J., Gomez Carrera, L., Guiot, J., Hallowell, R., Hayashi, H., Hetzel, J., Hirani, N., Homik, L., Hope-Gill, B., Hotchkin, D., Ichikado, K., Ilkovich, M., Izumi, S., Jassem, E., Jones, L., Jouneau, S., Kaner, R., Kang, J., Kawamura, T., Kessler, R., Kim, Y., Kishi, K., Kitamura, H., Kondoh, Y., Kono, C., Koschel, D., Kreuter, M., Kulkarni, T., Kus, J., Lebargy, F., Leon Jimenez, A., Luo, Q., Mageto, Y., Maher, T. M., Makino, S., Marchand-Adam, S., Marquette, C., Martinez, Sara, Martinez, M., Maturana Rozas, R., Miyazaki, Y., Moiseev, S., Molina-Molina, M., Malcolm, Joan Morrison, Morrow, L., Nambiar, A., Nishioka, Y., Nunes, H., Okamoto, M., Oldham, J., Otaola, M., Padilla, M., Park, J. S., Patel, N., Pesci, Riccardo, Piotrowski, W., Pitts, L., Poonyagariyagorn, H., Prasse, A., Quadrelli, S., Randerath, W., Refini, R., Reynaud-Gaubert, M., Riviere, F., Rodriguez Portal, J. A., Rosas, I., Rossman, M., Safdar, Z., Saito, T., Sakamoto, N., Salinas Fenero, M., Sauleda, J., Schmidt, S., Scholand, M. B., Schwartz, M., Shapera, S., Shlobin, O., Sigal, B., Silva Orellana, A., Skowasch, D., Song, J. W., Stieglitz, S., Stone, H., Strek, M., Suda, T., Sugiura, H., Takahashi, H., Takaya, H., Takeuchi, T., Thavarajah, K., Tolle, L., Tomassetti, S., Tomii, K., Valenzuela, C., Vancheri, C., Varone, Francesco, Veeraraghavan, S., Villar, A., Weigt, S., Wemeau, L., Wuyts, W., Xu, Z., Yakusevich, V., Yamada, Y., Yamauchi, H., Ziora, D., Richeldi L. (ORCID:0000-0001-8594-1448), Martinez R., Morrison L., Pesci A., and Varone F.
Abstract: Background: The INBUILD trial investigated the efficacy and safety of nintedanib versus placebo in patients with progressive fibrosing interstitial lung diseases (ILDs) other than idiopathic pulmonary fibrosis (IPF). We aimed to establish the effects of nintedanib in subgroups based on ILD diagnosis. Methods: The INBUILD trial was a randomised, double-blind, placebo-controlled, parallel group trial done at 153 sites in 15 countries. Participants had an investigator-diagnosed fibrosing ILD other than IPF, with chest imaging features of fibrosis of more than 10% extent on high resolution CT (HRCT), forced vital capacity (FVC) of 45% or more predicted, and diffusing capacity of the lung for carbon monoxide (DLco) of at least 30% and less than 80% predicted. Participants fulfilled protocol-defined criteria for ILD progression in the 24 months before screening, despite management considered appropriate in clinical practice for the individual ILD. Participants were randomly assigned 1:1 by means of a pseudo-random number generator to receive nintedanib 150 mg twice daily or placebo for at least 52 weeks. Participants, investigators, and other personnel involved in the trial and analysis were masked to treatment assignment until after database lock. In this subgroup analysis, we assessed the rate of decline in FVC (mL/year) over 52 weeks in patients who received at least one dose of nintedanib or placebo in five prespecified subgroups based on the ILD diagnoses documented by the investigators: hypersensitivity pneumonitis, autoimmune ILDs, idiopathic non-specific interstitial pneumonia, unclassifiable idiopathic interstitial pneumonia, and other ILDs. The trial has been completed and is registered with ClinicalTrials.gov, number NCT02999178. Findings: Participants were recruited between Feb 23, 2017, and April 27, 2018. Of 663 participants who received at least one dose of nintedanib or placebo, 173 (26%) had chronic hypersensitivity pneumonitis, 170 (26%) an autoimmune IL
Published: 2020

11. Electrical spinal stimulation, and imagining of lower limb movements to modulate brain-spinal connectomes that control locomotor-like behavior

Author: Gerasimenko, Y, Sayenko, D, Gad, P, Kozesnik, J, Moshonkina, T, Grishin, A, Pukhov, A, Moiseev, S, Gorodnichev, R, Selionov, V, Kozlovskaya, I, Edgerton, VR, Gerasimenko, Y, Sayenko, D, Gad, P, Kozesnik, J, Moshonkina, T, Grishin, A, Pukhov, A, Moiseev, S, Gorodnichev, R, Selionov, V, Kozlovskaya, I, and Edgerton, VR
Abstract: © 2018 Gerasimenko, Sayenko, Gad, Kozesnik, Moshonkina, Grishin, Pukhov, Moiseev, Gorodnichev, Selionov, Kozlovskaya and Edgerton. Neuronal control of stepping movement in healthy human is based on integration between brain, spinal neuronal networks, and sensory signals. It is generally recognized that there are continuously occurring adjustments in the physiological states of supraspinal centers during all routines movements. For example, visual as well as all other sources of information regarding the subject's environment. These multimodal inputs to the brain normally play an important role in providing a feedforward source of control. We propose that the brain routinely uses these continuously updated assessments of the environment to provide additional feedforward messages to the spinal networks, which provides a synergistic feedforwardness for the brain and spinal cord. We tested this hypothesis in 8 non-injured individuals placed in gravity neutral position with the lower limbs extended beyond the edge of the table, but supported vertically, to facilitate rhythmic stepping. The experiment was performed while visualizing on the monitor a stick figure mimicking bilateral stepping or being motionless. Non-invasive electrical stimulation was used to neuromodulate a wide range of excitabilities of the lumbosacral spinal segments that would trigger rhythmic stepping movements. We observed that at the same intensity level of transcutaneous electrical spinal cord stimulation (tSCS), the presence or absence of visualizing a stepping-like movement of a stick figure immediately initiated or terminated the tSCS-induced rhythmic stepping motion, respectively. We also demonstrated that during both voluntary and imagined stepping, the motor potentials in leg muscles were facilitated when evoked cortically, using transcranial magnetic stimulation (TMS), and inhibited when evoked spinally, using tSCS. These data suggest that the ongoing assessment of the environment within th
Published: 2018

12. Electrical spinal stimulation, and imagining of lower limb movements to modulate brain-spinal connectomes that control locomotor-like behavior

Author: Gerasimenko, Y, Sayenko, D, Gad, P, Kozesnik, J, Moshonkina, T, Grishin, A, Pukhov, A, Moiseev, S, Gorodnichev, R, Selionov, V, Kozlovskaya, I, Edgerton, VR, Gerasimenko, Y, Sayenko, D, Gad, P, Kozesnik, J, Moshonkina, T, Grishin, A, Pukhov, A, Moiseev, S, Gorodnichev, R, Selionov, V, Kozlovskaya, I, and Edgerton, VR
Abstract: © 2018 Gerasimenko, Sayenko, Gad, Kozesnik, Moshonkina, Grishin, Pukhov, Moiseev, Gorodnichev, Selionov, Kozlovskaya and Edgerton. Neuronal control of stepping movement in healthy human is based on integration between brain, spinal neuronal networks, and sensory signals. It is generally recognized that there are continuously occurring adjustments in the physiological states of supraspinal centers during all routines movements. For example, visual as well as all other sources of information regarding the subject's environment. These multimodal inputs to the brain normally play an important role in providing a feedforward source of control. We propose that the brain routinely uses these continuously updated assessments of the environment to provide additional feedforward messages to the spinal networks, which provides a synergistic feedforwardness for the brain and spinal cord. We tested this hypothesis in 8 non-injured individuals placed in gravity neutral position with the lower limbs extended beyond the edge of the table, but supported vertically, to facilitate rhythmic stepping. The experiment was performed while visualizing on the monitor a stick figure mimicking bilateral stepping or being motionless. Non-invasive electrical stimulation was used to neuromodulate a wide range of excitabilities of the lumbosacral spinal segments that would trigger rhythmic stepping movements. We observed that at the same intensity level of transcutaneous electrical spinal cord stimulation (tSCS), the presence or absence of visualizing a stepping-like movement of a stick figure immediately initiated or terminated the tSCS-induced rhythmic stepping motion, respectively. We also demonstrated that during both voluntary and imagined stepping, the motor potentials in leg muscles were facilitated when evoked cortically, using transcranial magnetic stimulation (TMS), and inhibited when evoked spinally, using tSCS. These data suggest that the ongoing assessment of the environment within th
Published: 2018

13. Revised 2017 international consensus on testing of ANCAs in granulomatosis with polyangiitis and microscopic polyangiitis [Position paper]

Author: Bossuyt, X, Cohen Tervaert, J, Arimura, Y, Blockmans, D, Flores Suárez, L, Guillevin, L, Hellmich, B, Jayne, D, Jennette, J, Kallenberg, C, Moiseev, S, Novikov, P, Radice, A, Savige, J, Sinico, R, Specks, U, van Paassen, P, Zhao, M, Rasmussen, N, Damoiseaux, J, Csernok, E, SINICO, RENATO ALBERTO, Csernok, E., Bossuyt, X, Cohen Tervaert, J, Arimura, Y, Blockmans, D, Flores Suárez, L, Guillevin, L, Hellmich, B, Jayne, D, Jennette, J, Kallenberg, C, Moiseev, S, Novikov, P, Radice, A, Savige, J, Sinico, R, Specks, U, van Paassen, P, Zhao, M, Rasmussen, N, Damoiseaux, J, Csernok, E, SINICO, RENATO ALBERTO, and Csernok, E.
Abstract: Anti-neutrophil cytoplasmic antibodies (ANCAs) are valuable laboratory markers used for the diagnosis of well-defined types of small-vessel vasculitis, including granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA). According to the 1999 international consensus on ANCA testing, indirect immunofluorescence (IIF) should be used to screen for ANCAs, and samples containing ANCAs should then be tested by immunoassays for proteinase 3 (PR3)-ANCAs and myeloperoxidase (MPO)-ANCAs. The distinction between PR3-ANCAs and MPO-ANCAs has important clinical and pathogenic implications. As dependable immunoassays for PR3-ANCAs and MPO-ANCAs have become broadly available, there is increasing international agreement that high-quality immunoassays are the preferred screening method for the diagnosis of ANCA-associated vasculitis. The present Consensus Statement proposes that high-quality immunoassays can be used as the primary screening method for patients suspected of having the ANCA-associated vaculitides GPA and MPA without the categorical need for IIF, and presents and discusses evidence to support this recommendation.
Published: 2017

14. Phase retrieval radio holography for large reflector antennas

Author: Kalinin, A. V.; Nizhny Novgorod State University, Moiseev, S. P.; Nizhny Novgorod State University, Kalinin, A. V.; Nizhny Novgorod State University, and Moiseev, S. P.; Nizhny Novgorod State University
Abstract: This article describes and implements an approach to the problem of determining the antenna aperture field distribution from only amplitude measurements of far-field pattern. We apply the quadratic approach for recovering the complex aperture field function from measurements of the pattern at different feed locations. The phase-retrieval procedure consists of minimizing a nonquadratic functional and a reliable iterative algorithm converging on the solution, regardless of the starting point, is thus obtained. This approach to phase-retrieval problem has been compared with well-known Misell algorithm. Also, the effectiveness of both algorithms has been verified by results of conventional with-phase holography with using the experimental data obtained on 70-meter mirror antenna.
Published: 2014

15. Complete reconstruction of the quantum state of a single-photon wave packet absorbed by a Doppler-broadened transition

Author: Moiseev, S. A., Kröll, Stefan, Moiseev, S. A., and Kröll, Stefan
Abstract: An idea for how to reconstruct the quantum state of a nonstationary single-photon wave packet absorbed in a macroscopic medium with inhomogeneously broadened lines is presented. An analytical treatment of the problem is performed and the requirements on the proposed scheme for complete recovery of the recorded nonstationary quantum state with a probability close to unity is described. The physical nature of the present scheme is also discussed.
Published: 2001

16. Observation of the Vertical Distribution and Behavior of Nektonic Squids Using Manned Submersibles

Author: Moiseev, S. I. and Moiseev, S. I.
Published: 1991

17. Observation of the Vertical Distribution and Behavior of Nektonic Squids Using Manned Submersibles

Author: Moiseev, S. I. and Moiseev, S. I.
Published: 1991

18. Broadband multiresonator quantum memory-interface

Author: Moiseev S., Gerasimov K., Latypov R., Perminov N., Petrovnin K., Sherstyukov O., Moiseev S., Gerasimov K., Latypov R., Perminov N., Petrovnin K., and Sherstyukov O.
Abstract: © 2018 The Author(s). In this paper we experimentally demonstrated a broadband scheme of the multiresonator quantum memory-interface. The microwave photonic scheme consists of the system of mini-resonators strongly interacting with a common broadband resonator coupled with the external waveguide. We have implemented the impedance matched quantum storage in this scheme via controllable tuning of the mini-resonator frequencies and coupling of the common resonator with the external waveguide. Proof-of-principal experiment has been demonstrated for broadband microwave pulses when the quantum efficiency of 16.3% was achieved at room temperature. By using the obtained experimental spectroscopic data, the dynamics of the signal retrieval has been simulated and promising results were found for high-Q mini-resonators in microwave and optical frequency ranges. The results pave the way for the experimental implementation of broadband quantum memory-interface with quite high efficiency η > 0.99 on the basis of modern technologies, including optical quantum memory at room temperature.

19. All-optical photon echo on a chip

Author: Moiseev E., Moiseev S., Moiseev E., and Moiseev S.
Abstract: © 2016 Astro Ltd.We demonstrate that a photon echo can be implemented by all-optical means using an array of on-chip high-finesse ring cavities whose parameters are chirped in such a way as to support equidistant spectra of cavity modes. When launched into such a system, a classical or quantum optical signal - even a single-photon field - becomes distributed between individual cavities, giving rise to prominent coherence echo revivals at well-defined delay times, controlled by the chirp of cavity parameters. This effect enables long storage times for high-throughput broadband optical delay and quantum memory.

20. Stationary and quasistationary light pulses in three-level cold atomic systems

Author: Moiseev S., Sidorova A., Ham B., Moiseev S., Sidorova A., and Ham B.
Abstract: We have studied stationary and quasistationary signal light pulses in cold Λ-type atomic media driven by counterpropagating control laser fields at the condition of electromagnetically induced transparency. By deriving a dispersion relation we present spectral and temporal properties of the signal light pulse and a significant influence of atomic decoherence on the coupled stationary light pulses for spatial splitting. Finally we discuss quasistationary light pulse evolution characterized by frozen spatial spreading for a robust coherent control of slow light pulses. © 2014 American Physical Society.

21. Light propagation in scanning nearfield optical microscopy probe

Author: Arslanov N., Moiseev S., Arslanov N., and Moiseev S.
Abstract: Katzenellenbaum method of cross sections is developed to the calculation of the light field parameters in nearfield microscopy probe. The dynamics of the modes propagation in the narrowing probe is studied when the probe aperture size is less than the wavelength λ of light. The analytical expressions for the modes wave numbers in the taper probe have been obtained, which essentially facilitate the analysis of the field parameters in the probe and allow to save the computing time considerably. The influence of walls inclination corner of the probe on modes amplitudes behavior is determined for the excitation of the probe by the monochromatic light. We demonstrate that the variation of the wall inclination corner can result to essential changing of the spatial field structure in the output probe aperture. Using the cross sections method we have studied the propagation and decreasing of the femtosecond pulse of light with 50 fs pulse duration in the taper probe.

22. Stationary and quasistationary light pulses in three-level cold atomic systems

Author: Moiseev S., Sidorova A., Ham B., Moiseev S., Sidorova A., and Ham B.
Abstract: We have studied stationary and quasistationary signal light pulses in cold Λ-type atomic media driven by counterpropagating control laser fields at the condition of electromagnetically induced transparency. By deriving a dispersion relation we present spectral and temporal properties of the signal light pulse and a significant influence of atomic decoherence on the coupled stationary light pulses for spatial splitting. Finally we discuss quasistationary light pulse evolution characterized by frozen spatial spreading for a robust coherent control of slow light pulses. © 2014 American Physical Society.

23. Light propagation in scanning nearfield optical microscopy probe

Author: Arslanov N., Moiseev S., Arslanov N., and Moiseev S.
Abstract: Katzenellenbaum method of cross sections is developed to the calculation of the light field parameters in nearfield microscopy probe. The dynamics of the modes propagation in the narrowing probe is studied when the probe aperture size is less than the wavelength λ of light. The analytical expressions for the modes wave numbers in the taper probe have been obtained, which essentially facilitate the analysis of the field parameters in the probe and allow to save the computing time considerably. The influence of walls inclination corner of the probe on modes amplitudes behavior is determined for the excitation of the probe by the monochromatic light. We demonstrate that the variation of the wall inclination corner can result to essential changing of the spatial field structure in the output probe aperture. Using the cross sections method we have studied the propagation and decreasing of the femtosecond pulse of light with 50 fs pulse duration in the taper probe.

24. All-optical photon echo on a chip

Author: Moiseev E., Moiseev S., Moiseev E., and Moiseev S.
Abstract: © 2016 Astro Ltd.We demonstrate that a photon echo can be implemented by all-optical means using an array of on-chip high-finesse ring cavities whose parameters are chirped in such a way as to support equidistant spectra of cavity modes. When launched into such a system, a classical or quantum optical signal - even a single-photon field - becomes distributed between individual cavities, giving rise to prominent coherence echo revivals at well-defined delay times, controlled by the chirp of cavity parameters. This effect enables long storage times for high-throughput broadband optical delay and quantum memory.

25. Efficacy of long-term treatment with TNF inhibitors in patients with refractory Takayasu arteritis

Author: Novikov P., Smitienko I., Moiseev S., Novikov P., Smitienko I., and Moiseev S.

26. CLINICAL MANIFESTATIONS AND FEATURES OF CRYOFIBRINOGENEMIA: RUSSIAN EXPERIENCE

Author: Shevtsova T., Smitienko I., Moiseev S., Novikov P., Shevtsova T., Smitienko I., Moiseev S., and Novikov P.

27. SAFETY AND EFFICACY OF SHORT-TERM TREATMENT WITH TOCILIZUMAB IN PATIENTS WITH REFRACTORY TAKAYASU ARTERITIS

Author: Novikov P., Smitienko I., Elonakov A., Koilubaeva G., Moiseev S., Novikov P., Smitienko I., Elonakov A., Koilubaeva G., and Moiseev S.

28. SHORT-TERM RESULTS OF THE NEW ANTI-TNF TREATMENT WITH CERTOLIZUMAB PEGOL IN REFRACTORY TAKAYASU'S ARTERITIS

Author: Novikov P., Smitienko I., Zhiliaev E., Elonakov A., Moiseev S., Novikov P., Smitienko I., Zhiliaev E., Elonakov A., and Moiseev S.

29. Rituximab as induction therapy in relapsing eosinophilic granulomatosis with polyangiitis: A report of 6 cases

Author: Novikov P., Moiseev S., Smitienko I., Zagvozdkina E., Novikov P., Moiseev S., Smitienko I., and Zagvozdkina E.
Abstract: Objective: Recently few reports have suggested a potential benefit of rituximab in patients with eosinophilic granulomatosis with polyangiitis (EGPA). However, the current evidence is limited. We describe the efficacy and safety of rituximab in six patients with relapsing EGPA. Methods: Candidates for rituximab therapy were selected from a cohort of 118 patients with EGPA. The main indication for B-cells depletion was moderately severe or severe relapsing disease that was refractory to conventional immunosuppression. A primary end-point was a complete or partial remission within 3 to 6 months after rituximab administration. Results: All six patients (four ANCA-positive and two ANCA-negative) had active EGPA manifesting by severe lung disease and/or deteriorating peripheral neuropathy. The median duration of follow-up after the first rituximab dose administration was 10 months. All patients rapidly responded to rituximab treatment, e.g. disappearance of lung infiltrates, improvement of asthmatic symptoms, at least partial recovery of motor and sensory function. Within 3 to 6 months, complete (4/6) or partial (2/6) remission was achieved in all patients. After switching to rituximab all patients except one discontinued cyclophosphamide or other immunomodulators. Four patients continued maintenance treatment with rituximab. One patient developed severe bronchospasm during infusion and two patients presented with moderately severe purulent bronchitis that was successfully treated with intravenous antibiotics. Conclusion: Our retrospective case series suggest that rituximab may be effective for induction of remission in selected EGPA patients. These data warrant further studies to evaluate safety and efficacy of rituximab in EGPA. (C) 2015 Societe francaise de rhumatologie. Published by Elsevier Masson SAS. All rights reserved.

30. Testing for antineutrophil cytoplasmic antibodies (ANCAs) in patients with systemic vasculitides and other diseases

Author: Novikov P., Smitienko I., Bulanov N., Zykova A., Moiseev S., Novikov P., Smitienko I., Bulanov N., Zykova A., and Moiseev S.
Abstract: [No abstract available]

31. Giant cell arteritis, infections and biologics

Author: Moiseev S., Novikov P., Smitienko I., Shchegoleva E., Moiseev S., Novikov P., Smitienko I., and Shchegoleva E.
Abstract: [No abstract available]

32. Biological agents for giant cell arteritis: Treat to target

Author: Moiseev S., Novikov P., Meshkov A., Smitienko I., Moiseev S., Novikov P., Meshkov A., and Smitienko I.
Abstract: [No abstract available]

33. Crystal field and hyperfine structure of Er 3+ 167 in YP O4:Er single crystals: High-resolution optical and EPR spectroscopy

Author: Popova M., Klimin S., Moiseev S., Gerasimov K., Minnegaliev M., Baibekov E., Shakurov G., Bettinelli M., Chou M., Popova M., Klimin S., Moiseev S., Gerasimov K., Minnegaliev M., Baibekov E., Shakurov G., Bettinelli M., and Chou M.
Abstract: © 2019 American Physical Society. We report on a high-resolution optical and magneto-optical spectroscopy, luminescence, and electron paramagnetic resonance (EPR) studies of yttrium orthophosphate single crystals doped with erbium, which are promising telecom-wavelength materials for applications in quantum electronics and quantum information processing. An observation of the hyperfine structure in optical spectra of Er167 isotope in Er:YPO4 is presented. Energies and symmetries of 40 crystal-field levels of Er3+ in Er:YPO4 and g factors of some of them were determined and successfully modeled on the basis of crystal-field calculations. The obtained set of crystal-field parameters was used in modeling the hyperfine structure observed in the optical and EPR spectra of Er:YPO4 single crystals.

34. Quantum random numbers from a fiber-optic photon-pair source

Author: Smirnov M., Petrovnin K., Fedotov I., Moiseev S., Zheltikov A., Smirnov M., Petrovnin K., Fedotov I., Moiseev S., and Zheltikov A.
Abstract: © 2019 Astro Ltd. We demonstrate a fiber-optic source of random numbers in which random-number generation (RNG) is implemented via an inherently quantum process-detection of correlated photon pairs produced by spontaneous four-wave mixing (FWM) inside an optical fiber. The detection times of individual photon pairs, generated in our RNG scheme via phase-matched FWM in a highly nonlinear photonic-crystal fiber with a suitable dispersion profile, are converted into megabit-size binary sequences, serving as strings of random numbers. The randomness of these bit strings is verified by the National Institute of Standards and Technology Statistical Test Suite. We identify FWM regimes in which mode-locked short-pulse laser sources can provide a high peak power needed to drive photon-pair generation in optical fibers without an excessive loss of randomness due to unwanted patterns in the RNG photon-pair output.

35. Broadband quantum light on a fiber-optic platform: From biphotons and heralded single photons to bright squeezed vacuum

Author: Petrovnin K., Smirnov M., Fedotov I., Voronin A., Latypov I., Shmelev A., Talipov A., Matveeva T., Fedotov A., Moiseev S., Zheltikov A., Petrovnin K., Smirnov M., Fedotov I., Voronin A., Latypov I., Shmelev A., Talipov A., Matveeva T., Fedotov A., Moiseev S., and Zheltikov A.
Abstract: © 2019 Astro Ltd. Four-wave mixing (FWM) of ultrashort laser pulses in a highly nonlinear photonic-crystal fiber is shown to provide a multimodal source of broadband quantum states of light. In the regime of low pump powers, generation of two-photon states and heralded single photons with a bandwidth up to ≈6 THz is demonstrated within an FWM-sideband tunability range of ≈55 THz. In the modality of heralded single-photon generation, three-detector measurements of the conditional second-order correlation function reveal a strong antibunching in the signal-photon channel, with more than 99.2% of the signal counts identified as truly single-photon states. At high pump powers, two-detector signal-idler correlation function measurements indicate broadband bright squeezed vacuum generation.

36. Merging and Repulsion of Eigenmodes in Multiresonator Memory

Author: Petrovnin K., Perminov N., Sherstyukov O., Moiseev S., Petrovnin K., Perminov N., Sherstyukov O., and Moiseev S.
Abstract: © 2019, Allerton Press, Inc. Abstract: The merging and repulsion of eigenmodes in a multiresonator microwave memory integrated into a waveguide-resonator system are investigated. The merging of eigenmodes is explained on the basis of theoretical modeling and experimental data, and the possibility of controlling the spectral characteristics of the memory is demonstrated.

37. Quantum computer based on triangular atom-photon molecule

Author: Moiseev S., Ablayev F., Andrianov S., Vasiliev A., Moiseev S., Ablayev F., Andrianov S., and Vasiliev A.
Abstract: © 2019 SPIE. Configuration of three resonators connected located in triangular scheme is considered for implementation of single and two-qubit gates. Each of the resonators can be coupled with its three-level atom and with neighbor resonator in defined moment of time. The regimes for coherent control of atom-photonic molecule states in the studied scheme and realization of single- A nd two qubit gates on this basis are theoretically investigated. The two qubit gate is considered in two various regimes: At the sequential switching on the interactions with step by step transfer of excitation and when central resonator is coupled simultaneously with two side resonators and excitation is transferring in the course of single process. Comparison of these two approaches is performed and recommendations for the construction of quantum computers on the atom-photon molecular states are presented.

38. Broadband impedance matching in white cavity

Author: Moiseev E., Gerasimov K., Sabooni M., Tashchilina A., Moiseev S., Moiseev E., Gerasimov K., Sabooni M., Tashchilina A., and Moiseev S.
Abstract: © 2019 SPIE. We propose a mechanism for increasing the bandwidth of impedance matching in an optical cavity. We demonstrate that placing a compensating medium with abnormal dispersion inside the cavity stretches an optical range by an order of magnitude. As a specific physical system, we consider a double-lambda scheme, where reversible absorption and compensating dispersion could be implemented via two-photon Raman absorption and gain respectively. To prove experimental feasibility of our proposal we study the application of the scheme for an optical quantum storage and provide thorough analysis of possible experimental realizations.

39. Electrical spinal stimulation, and imagining of lower limb movements to modulate brain-spinal connectomes that control locomotor-like behavior

Author: Gerasimenko Y., Sayenko D., Gad P., Kozesnik J., Moshonkina T., Grishin A., Pukhov A., Moiseev S., Gorodnichev R., Selionov V., Kozlovskaya I., Edgerton V., Gerasimenko Y., Sayenko D., Gad P., Kozesnik J., Moshonkina T., Grishin A., Pukhov A., Moiseev S., Gorodnichev R., Selionov V., Kozlovskaya I., and Edgerton V.
Abstract: © 2018 Gerasimenko, Sayenko, Gad, Kozesnik, Moshonkina, Grishin, Pukhov, Moiseev, Gorodnichev, Selionov, Kozlovskaya and Edgerton. Neuronal control of stepping movement in healthy human is based on integration between brain, spinal neuronal networks, and sensory signals. It is generally recognized that there are continuously occurring adjustments in the physiological states of supraspinal centers during all routines movements. For example, visual as well as all other sources of information regarding the subject's environment. These multimodal inputs to the brain normally play an important role in providing a feedforward source of control. We propose that the brain routinely uses these continuously updated assessments of the environment to provide additional feedforward messages to the spinal networks, which provides a synergistic feedforwardness for the brain and spinal cord. We tested this hypothesis in 8 non-injured individuals placed in gravity neutral position with the lower limbs extended beyond the edge of the table, but supported vertically, to facilitate rhythmic stepping. The experiment was performed while visualizing on the monitor a stick figure mimicking bilateral stepping or being motionless. Non-invasive electrical stimulation was used to neuromodulate a wide range of excitabilities of the lumbosacral spinal segments that would trigger rhythmic stepping movements. We observed that at the same intensity level of transcutaneous electrical spinal cord stimulation (tSCS), the presence or absence of visualizing a stepping-like movement of a stick figure immediately initiated or terminated the tSCS-induced rhythmic stepping motion, respectively. We also demonstrated that during both voluntary and imagined stepping, the motor potentials in leg muscles were facilitated when evoked cortically, using transcranial magnetic stimulation (TMS), and inhibited when evoked spinally, using tSCS. These data suggest that the ongoing assessment of the environment within th

40. Spectroscopy of cascade multiresonator quantum memory

Author: Perminov N., Petrovnin K., Gerasimov K., Kirillov R., Latypov R., Sherstyukov O., Moiseev S., Perminov N., Petrovnin K., Gerasimov K., Kirillov R., Latypov R., Sherstyukov O., and Moiseev S.
Abstract: © 2018, Institution of Russian Academy of Sciences. All rights reserved. We study spectral properties of a cascaded multiresonator microwave quantum memory integrated into a waveguide-resonator system. On the basis of experimental data, we reconstruct the internal parameters of the circuit under study, give estimates of quantum efficiency, and show the possibility of achieving optimal conditions for its realization.

41. High-resolution magneto-optical spectroscopy of LiYF4 7: Er 3+ 167, Er 3+ 166 and analysis of hyperfine structure of ultranarrow optical transitions

Author: Gerasimov K., Minnegaliev M., Malkin B., Baibekov E., Moiseev S., Gerasimov K., Minnegaliev M., Malkin B., Baibekov E., and Moiseev S.
Abstract: © 2016 American Physical Society.We performed high-resolution magneto-optical spectroscopy of the hyperfine transitions from I15/24 to the I13/24 and I9/24 multiplets of Er3+167 and Er3+166 in an isotopically purified LiYF47 crystal in various external magnetic fields up to 0.7 T. The obtained experimental results are interpreted in the framework of the generalized theoretical approach. The derived model successfully explains all the experimentally observed optical hyperfine transitions by using a single set of basic parameters found for the crystal-field interaction, magnetic dipole and electric quadrupole hyperfine interactions, together with Zeeman interactions at different orientations of the external magnetic field. A number of the studied quantum transitions appears to be promising for use in Raman quantum storage at optical telecommunication wavelengths.

42. Time-bin quantum RAM

Author: Moiseev E., Moiseev S., Moiseev E., and Moiseev S.
Abstract: © 2016 Informa UK Limited, trading as Taylor & Francis Group.We have proposed a compact scheme of quantum random access memory (qRAM) based on the impedance matched multi-qubit photon echo quantum memory incorporated with the control four-level atom in two coupled QED cavities. A set of matching conditions for basic physical parameters of the qRAM scheme that provides an efficient quantum control of the fast single photon storage and readout has been found. In particular, it has been discovered that the efficient qRAM operations are determined by the specific properties of the excited photonic molecule coupling the two QED cavities. Herein, the maximal efficiency of the qRAM is realized when the cooperativity parameter of the photonic molecule equals to unity that can be experimentally achievable. We have also elaborated upon the new quantum address scheme where the multi-time-bin photon state is used for the control of the four-level atom during the readout of the photonic qubits from the quantum memory. The scheme reduces the required number of logical elements to one. Experimental implementation by means of current quantum technologies in the optical and microwave domains is also discussed.

43. Defect modes of one-dimensional photonic-crystal structure with a resonance nanocomposite layer

Author: Moiseev S., Ostatochnikov V., Moiseev S., and Ostatochnikov V.
Abstract: © 2016 Kvantovaya Elektronika and Turpion Ltd.We have studied the defect modes of a structure of Fabry-Perot interferometer type, in which the layer separating Bragg mirrors is made of a heterogeneous composite material with metallic nanoscale inclusions. Effective optical characteristics of the nanocomposite material have resonance singularities in the visible region of the spectrum, which are conditioned by the surface plasmon resonance of metallic nanoparticles. It is shown that the spectral profile of the energy bandgap of the photonic structure can be modified by varying the volume fraction and size of nanoparticles. The interrelation of splitting and shift of defect modes with structural parameters of a nanocomposite layer is studied by means of a numerical-graphical method with allowance for the frequency dependences of phases and amplitudes of reflectances in Bragg mirrors.

44. High-resolution magneto-optical spectroscopy of LiYF4 7: Er 3+ 167, Er 3+ 166 and analysis of hyperfine structure of ultranarrow optical transitions

Author: Gerasimov K., Minnegaliev M., Malkin B., Baibekov E., Moiseev S., Gerasimov K., Minnegaliev M., Malkin B., Baibekov E., and Moiseev S.
Abstract: © 2016 American Physical Society.We performed high-resolution magneto-optical spectroscopy of the hyperfine transitions from I15/24 to the I13/24 and I9/24 multiplets of Er3+167 and Er3+166 in an isotopically purified LiYF47 crystal in various external magnetic fields up to 0.7 T. The obtained experimental results are interpreted in the framework of the generalized theoretical approach. The derived model successfully explains all the experimentally observed optical hyperfine transitions by using a single set of basic parameters found for the crystal-field interaction, magnetic dipole and electric quadrupole hyperfine interactions, together with Zeeman interactions at different orientations of the external magnetic field. A number of the studied quantum transitions appears to be promising for use in Raman quantum storage at optical telecommunication wavelengths.

45. A quantum computer in the scheme of an atomic quantum transistor with logical encoding of qubits

Author: Moiseev S., Andrianov S., Moiseev E., Moiseev S., Andrianov S., and Moiseev E.
Abstract: A scheme of a multiqubit quantum computer on atomic ensembles using a quantum transistor implementing two qubit gates is proposed. We demonstrate how multiatomic ensembles permit one to work with a large number of qubits that are represented in a logical encoding in which each qubit is recorded on a superposition of single-particle states of two atomic ensembles. The access to qubits is implemented by appropriate phasing of quantum states of each of atomic ensembles. An atomic quantum transistor is proposed for use when executing two qubit operations. The quantum transistor effect appears when an excitation quantum is exchanged between two multiatomic ensembles located in two closely positioned QED cavities connected with each other by a gate atom. The dynamics of quantum transfer between atomic ensembles can be different depending on one of two states of the gate atom. Using the possibilities of control for of state of the gate atom, we show the possibility of quantum control for the state of atomic ensembles and, based on this, implementation of basic single and two qubit gates. Possible implementation schemes for a quantum computer on an atomic quantum transistor and their advantages in practical implementation are discussed. © 2013 Pleiades Publishing, Ltd.

46. Quantum computer with atomic logical qubits encoded on macroscopic three-level systems in common quantum electrodynamic cavity

Author: Ablayev F., Andrianov S., Moiseev S., Vasiliev A., Ablayev F., Andrianov S., Moiseev S., and Vasiliev A.
Abstract: We propose an effective realization of the universal set of elementary quantum gates in solid state quantum computer based on macroscopic (or mesoscopic) resonance systems - multiatomic coherent ensembles, squids or quantum dots in quantum electrodynamic cavity. We exploit an encoding of logical qubits by the pairs of the macroscopic two- or three-level atoms that is working in a Hilbert subspace of all states inherent to these atomic systems. In this subspace, logical single qubit gates are realized by the controlled reversible transfer of single atomic excitation in the pair via the exchange of virtual photons and by the frequency shift of one of the atomic ensembles in a pair. In the case of two-level systems, the logical two-qubit gates are performed by the controlling of Lamb shift magnitude in one atomic ensemble, allowing/blocking the excitation transfer in a pair, respectively, that is controlled by the third atomic system of another pair. When using three-level systems, we describe the NOT-gate in the atomic pair controlled by the transfer of working atomic excitation to the additional third level caused by direct impact of the control pair excitation. Finally, we discuss advantages of the proposed physical system for accelerated computation of some useful quantum gates. © 2013 Pleiades Publishing, Ltd.

47. Kinetics of pulse-induced magnon Bose-Einstein condensate

Author: Andrianov S., Bochkarev V., Moiseev S., Andrianov S., Bochkarev V., and Moiseev S.
Abstract: © 2014, EDP Sciences, SIF, Springer-Verlag Berlin Heidelberg. We have analysed the kinetics of Bose-Einstein condensed (BEC) magnons after pulsed excitation in a ferromagnet at room and low temperatures. For this purpose, we have derived the kinetic equations using the nonequilibrium statistical operator method to describe the general form of the interactions in the magnon system. On the basis of this approach, we have analysed the nonlinear properties of the magnon BEC kinetics caused by interactions with magnon reservoir modes and phonons. We have found that formation of a quasi-stationary BEC magnon state is possible not only at room temperature but also at low temperatures, where the magnon-phonon interaction leads to formation of a residual BEC state with magnon population much larger than at room temperature. It was also observed that a moderately strong four-particle part of the magnon-magnon interaction violating the number of magnons is sufficient to facilitate magnon BEC formation. The predicted long-lived magnon BEC state could be promising for realisation of macroscopic qubits.

48. Scalable time reversal of Raman echo quantum memory and quantum waveform conversion of light pulse

Author: Moiseev E., Moiseev S., Moiseev E., and Moiseev S.
Abstract: We have found a new hidden symmetry of time reversal light-atom interaction in the photon echo quantum memory with Raman atomic transition. The time-reversed quantum memory creates generalized conditions for the ideal compression/decompression of time duration of the input light pulses and its wavelength. Based on a general analytical approach to this scheme, we have studied the optimal conditions for the light field compression/decompression in resonant atomic systems characterized by realistic spectral properties. The demonstrated necessary conditions for the effective quantum conversion of the light waveform and wavelength are also discussed for various possible realizations of the quantum memory scheme. The performed study promises new capabilities for fundamental study of the light-atom interaction and deterministic quantum manipulation of the light field, significant for quantum communication and quantum computing. © IOP Publishing and Deutsche Physikalische Gesellschaft.

49. Solid state multi-ensemble quantum computer in cavity quantum electrodynamics model

Author: Moiseev S., Andrianov S., Gubaidullin F., Moiseev S., Andrianov S., and Gubaidullin F.
Abstract: The first realization of solid state quantum computer was demonstrated recently by using artificial atoms - transmons in superconducting resonator. Here, we propose a novel quantum computer based on quantum electrodynamic cavity coupling many quantum nodes of controlled atomic ensembles. The quantum computer contains quantum memory and processing nodes. For the first time, we find the optimal practically attainable parameters of the atoms and optical scheme of the computer for realization of the multimode quantum memory for the photonic qubits with efficiency close to 100%. Then we reveal self modes for reversible transfer of the qubits between the quantum memory node and the processing nodes. Also, we find a realization of iSWAP gate via direct coupling of two processing nodes with an operation rate accelerated proportionally to the number of atoms in the nodes. Collective dynamic and static blockade mechanisms are proposed for realization of $\sqrt {iSWAP} $ quantum gate in multi atomic ensembles. A large number of the two-qubit gates can be simultaneously realized that opens a possibility for parallel quantum processing in the proposed quantum computer. © 2011 Pleiades Publishing, Ltd.

50. Efficiency and fidelity of photon-echo quantum memory in an atomic system with longitudinal inhomogeneous broadening

Author: Moiseev S., Arslanov N., Moiseev S., and Arslanov N.
Abstract: We have performed a theoretical analysis of the photon-echo-based quantum memory realized recently in A. L. Alexander, Phys. Rev. Lett. 96, 043602 (2006) in the medium with linear correlation between atomic spatial coordinates and frequency detunings of the inhomogeneously broadened transition. A more general vision on the physical picture of temporal and spatial light-atoms dynamics has been obtained in the analytical solutions, taking into account the atomic phase relaxation, inhomogeneous broadening, and arbitrary parameters of the probe light pulses. We have evaluated preferable experimental conditions for the storage of incoming data light field modes where quantum memory efficiency and fidelity have been found. Physics of high efficiency in the forward geometry of the quantum memory and advantages for the realization of more universal long-lived storage on this basis are clarified. © 2008 The American Physical Society.

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