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INTRODUCTION: The objective of this study was to investigate the diagnostic potential of bacterial biomarkers by comparing the performance of molecular detection assays with clinical assessments of dogs oral health performed by veterinarians. METHODS: Supragingival and subgingival plaque samples were collected from 127 client-owned dogs, pre-booked for procedures under general anesthesia, visiting veterinary practices in the United States. DNA was extracted and bacterial biomarkers quantified using quantitative polymerase chain reaction. Gingivitis and periodontitis were recorded by a trained clinician using the Weighted Gingivitis Periodontitis Score which involved assessing the buccal surfaces of 18 teeth while under general anesthesia. Intraoral dental radiographs of the left and right mandibular first molar teeth were also obtained. These data were then used to establish the diagnostic performance of the molecular assay to detect periodontitis. RESULTS: An initial conscious, visual oral examination performed by the veterinarian identified 67.7% of dogs as having periodontitis, but examination under general anesthesia indicated a higher proportion (86.6%). Analysis of supragingival plaque samples collected by veterinarians from conscious and unconscious dogs demonstrated the assay had an accuracy of 77.7 to 80.9%, a sensitivity of 77.6 to 81.0%, and a specificity of 80.0%. DISCUSSION: Use of this molecular screening tool in conscious dogs has the potential to improve early periodontal disease detection and support veterinary decision making, ultimately improving the oral health of dogs and consequently their quality of life.

Antimicrobial resistance is a global health threat and there is an urgent need to manage antibiotic use to slow its development. However, antimicrobial stewardship interventions in low- and middle-income countries (LMIC) have been limited in terms of their resourcing, feasibility and effectiveness in the face of greater challenges in child mortality. We sought to gather together examples of antibiotic use problems faced by clinicians in LMIC, many of which are unique to these settings, and real-world antimicrobial stewardship solutions identified, with the goal of learning broader lessons that might be applicable across LMIC.

OBJECTIVE: The introduction of a new clinical pharmacist workforce via Primary Care Networks (PCNs) is a recent national policy development in the National Health Service in England. This study elicits the perspectives of people with responsibility for local implementation of this national policy package. Attention to local delivery is necessary to understand the contextual factors shaping the integration of the new clinical pharmacy workforce, and thus can be expected to influence future role development. DESIGN: A qualitative, interview study SETTING AND PARTICIPANTS: PCN Clinical Directors and senior pharmacists across 17 PCNs in England (n=28) ANALYSIS: Interviews were transcribed, coded and organised using the framework method. Thematic analysis and complex systems modelling were then undertaken iteratively to develop the themes. RESULTS: Findings were organised into two overarching themes: (1) local organisational innovations of a national policy under conditions of uncertainty; and (2) local multiprofessional decision-making on clinical pharmacy workforce integration and initial task assignment. Although a phased implementation of the PCN package was planned, the findings suggest that processes of PCN formation and clinical pharmacist workforce integration were closely intertwined, with underpinning decisions taking place under conditions of considerable uncertainty and workforce pressures. CONCLUSIONS: National policy decisions that required General Practitioners to form PCNs at the same time as they integrated a new workforce risked undermining the potential of both PCNs and the new workforce. PCNs require time and support to fully form and integrate clinical pharmacists if successful role development is to occur. Efforts to incentivise delivery of PCN pharmacy services in future must be responsive to local capacity.

OBJECTIVE: The introduction of a new clinical pharmacist workforce via Primary Care Networks (PCNs) is a recent national policy development in the National Health Service in England. This study elicits the perspectives of people with responsibility for local implementation of this national policy package. Attention to local delivery is necessary to understand the contextual factors shaping the integration of the new clinical pharmacy workforce, and thus can be expected to influence future role development. DESIGN: A qualitative, interview study SETTING AND PARTICIPANTS: PCN Clinical Directors and senior pharmacists across 17 PCNs in England (n=28) ANALYSIS: Interviews were transcribed, coded and organised using the framework method. Thematic analysis and complex systems modelling were then undertaken iteratively to develop the themes. RESULTS: Findings were organised into two overarching themes: (1) local organisational innovations of a national policy under conditions of uncertainty; and (2) local multiprofessional decision-making on clinical pharmacy workforce integration and initial task assignment. Although a phased implementation of the PCN package was planned, the findings suggest that processes of PCN formation and clinical pharmacist workforce integration were closely intertwined, with underpinning decisions taking place under conditions of considerable uncertainty and workforce pressures. CONCLUSIONS: National policy decisions that required General Practitioners to form PCNs at the same time as they integrated a new workforce risked undermining the potential of both PCNs and the new workforce. PCNs require time and support to fully form and integrate clinical pharmacists if successful role development is to occur. Efforts to incentivise delivery of PCN pharmacy services in future must be responsive to local capacity.

Well characterised cognitive and perceptual impairments in schizophrenia may not be diagnostically specific with some studies suggesting no significant differences between psychotic disorders. This transdiagnostic ambiguity is paralleled in the boundary distinctions between psychotic disorders and the sub-threshold symptomatology of schizotypy. The current study used the CNTRACS test battery to explore if performance deficits in visual integration, relational memory and goal maintenance were specific to schizophrenia or extend to other psychotic disorders; and if task performance varied between individuals with schizophrenia and schizotypy in healthy adults. The sample consisted of healthy controls, and patients who met DSM-IV criteria for schizophrenia, other psychotic disorders and non-psychotic disorders who were tested in person; and an online sample of self-assessed healthy adults. No significant differences were found in performance between patients with schizophrenia and other psychotic disorders in contrast to non-psychotic disorders and healthy controls. The high schizotypy group performed better on the tasks compared to the other psychoses and schizophrenia groups. There were no differences in the healthy control group between individuals with high versus low schizotypy or between in-person and online task performance. These findings support the notion that cognitive and perceptual impairments in schizophrenia extend to other psychotic disorders but are discontinuous with schizotypy. This study provides insights into similarities between schizophrenia and other psychotic disorders with regards to the potential neural substrates underpinning these functions and supports the use of online tools for assessing domains of cognition and perception.

We present the technical design, construction and testing of the Colibri telescope array at Elginfield Observatory near London, Ontario, Canada. Three 50-cm telescopes are arranged in a triangular array and are separated by 110-160 metres. During operation, they will monitor field stars at the intersections of the ecliptic and galactic plane for serendipitous stellar occultations (SSOs) by trans-Neptunian objects (TNOs). At a frame rate of 40 frames per second (fps), Fresnel diffraction in the occultation light curve can be resolved and, with coincident detections, be used to estimate basic properties of the occulting object. Using off-the-shelf components, the Colibri system streams imagery to disk at a rate of 1.5 GB/s for next-day processing by a custom occultation detection pipeline. The imaging system has been tested and is found to perform well, given the moderate site conditions. Limiting magnitudes at 40 fps are found to be about 12.1 (temporal SNR=5, visible light Gaia G band) with time-series standard deviations ranging from about 0.035 mag to >0.2 mag. SNR is observed to decrease linearly with magnitude for stars fainter than about G = 9.5 mag. Brighter than this limit, SNR is constant, suggesting that atmospheric scintillation is the dominant noise source. Astrometric solutions show errors typically less than approximately 0.3 pixels (0.8 arc seconds) without a need for high-order corrections., Comment: 17 pages, 8 figures, submitted to Frontiers in Astronomy and Space Sciences

The mass ranges of meteors, imaged by electro-optical (EO) cameras and backscatter radar receivers, for the most part do not overlap. Typical EO systems detect meteoroid masses down to 10$^{-5}$ kg or roughly magnitude +2 meteors when using moderate field of view optics, un-intensified optical components, and meteor entry velocities around 45 km/sec. This is near the high end of the mass range of typical meteor radar observations. Having the same mass meteor measured by different sensor wavelength bands would be a benefit in terms of calibrating mass estimations for both EO and radar. To that end, the University of Western Ontario (UWO) has acquired and deployed a very low light imaging system based on an electron-multiplying CCD camera technology. This embeds a very low noise, per pixel intensifier chip in a cooled camera setup with various options for frame rate, region of interest and binning. The EO system of optics and sensor was optimally configured to collect 32 frames per second in a square field of view 14.7 degrees on a side, achieving a single-frame stellar limiting magnitude of m$_G$ = +10.5. The system typically observes meteors of +6.5. A key development in this pipeline has been the first true application of matched filter processing to process the faintest meteors possible in the EMCCD system while also yielding high quality automated metric measurements of meteor focal plane positions. With pairs of EMCCD systems deployed at two sites, triangulation and high accuracy orbits are one of the many products being generated by this system. These measurements will be coupled to observations from the Canadian Meteor Orbit Radar (CMOR) used for meteor plasma characterization and the Canadian Automated Meteor Observatory (CAMO) high resolution mirror tracking system., Comment: 50 pages, 19 figures, accepted to Experimental Astronomy

Australia and New Zealand have achieved excellent community control of COVID-19 infection. In light of the imminent COVID-19 vaccination roll out in both countries, representatives of all adult and paediatric allogeneic bone marrow transplant and cellular therapy (TCT) centres as well as representatives from autologous transplant only centres in Australia and New Zealand collaborated with infectious diseases specialists with expertise in TCT on this consensus position statement regarding COVID-19 vaccination in TCT patients in Australia and New Zealand. It is our recommendation that TCT patients, should have expedited access to high-efficacy COVID-19 vaccines given that these patients are at high risk of morbidity and mortality from COVID-19 infection. We also recommend prioritising vaccination of TCT healthcare workers and household members of TCT patients. Vaccination should not replace other public health measures in TCT patients given the effectiveness of COVID-19 vaccination in TCT patients is unknown. Furthermore, given the limited available data, prospective collection of safety and efficacy data of COVID-19 vaccination in this patient group is a priority.

In order to effectively evaluate complex interventions, there have been calls for the further integration of qualitative methods. Qualitative process studies of brief alcohol interventions and medicines reviews are notably lacking. This article provides a grounded example through the presentation of findings from an embedded qualitative process evaluation of a multi-site, pilot cluster RCT of a new intervention: the Medicines and Alcohol Consultation (MAC). MAC is designed to increase the capacity of community pharmacists (CPs) to conduct person-centred medicines reviews in which the subject of alcohol consumption is raised in connection with medications and associated health conditions. Participant-focused qualitative studies (interviews, observations, recorded consultations) sought to understand how CPs engaged with and implemented MAC in context. This article documents effects of the intervention on developing person-centred consultation practice and highlights how qualitative process studies can be used formatively to develop middle range programme theory and to optimise intervention design for testing in a definitive RCT.

The current interest in individualized food through additive manufacturing has identified a need for more information on the formulation and printability of potential ingredients. Here, the effect of formulation parameters of casein–whey protein suspensions like the pH (4.8–5.4) as well as the casein content (8.0–12.0% (w/w)) mixed with whey protein (2.0–3.0% (w/w)) and the effect of pre-processing parameters including the denaturation of whey proteins (80 °C, 10 min; adjusted pH 6.55, 6.9 and 7.1) on the gel formation via the pH–temperature (T)-route was studied. Rheological measurements showed that the sol–gel transition temperature (G’ = 1 Pa) decreased and the aggregation rate of the casein–whey protein suspensions increased with increasing heating pH value. The aggregation rate was considered to be a key parameter predicting the printability of formulations. By exceeding a certain aggregation rate (250 Pa/10 K), casein–whey protein suspensions were found to be printable resulting in firm and stable gels.

The mass ranges of meteors, imaged by electro-optical (EO) cameras and backscatter radar receivers, for the most part do not overlap. Typical EO systems detect meteoroid masses down to 10$^{-5}$ kg or roughly magnitude +2 meteors when using moderate field of view optics, un-intensified optical components, and meteor entry velocities around 45 km/sec. This is near the high end of the mass range of typical meteor radar observations. Having the same mass meteor measured by different sensor wavelength bands would be a benefit in terms of calibrating mass estimations for both EO and radar. To that end, the University of Western Ontario (UWO) has acquired and deployed a very low light imaging system based on an electron-multiplying CCD camera technology. This embeds a very low noise, per pixel intensifier chip in a cooled camera setup with various options for frame rate, region of interest and binning. The EO system of optics and sensor was optimally configured to collect 32 frames per second in a square field of view 14.7 degrees on a side, achieving a single-frame stellar limiting magnitude of m$_G$ = +10.5. The system typically observes meteors of +6.5. A key development in this pipeline has been the first true application of matched filter processing to process the faintest meteors possible in the EMCCD system while also yielding high quality automated metric measurements of meteor focal plane positions. With pairs of EMCCD systems deployed at two sites, triangulation and high accuracy orbits are one of the many products being generated by this system. These measurements will be coupled to observations from the Canadian Meteor Orbit Radar (CMOR) used for meteor plasma characterization and the Canadian Automated Meteor Observatory (CAMO) high resolution mirror tracking system., Comment: 50 pages, 19 figures, accepted to Experimental Astronomy

Acquired aplastic anaemia is a rare, serious, immunologically mediated bone marrow failure syndrome, characterised by marrow hypoplasia of varying severity and significant pancytopenia. Careful attention and investigation, including molecular testing, is required to confirm the diagnosis and exclude other mimicking conditions, such as inherited bone marrow failure syndromes. In a proportion of patients, the disease evolves to myelodysplasia or acute myeloid leukaemia and in some there is an association with paroxysmal nocturnal haemoglobinuria. The disease has a major impact on patient quality of life. Haemopoietic stem/progenitor cell transplantation for eligible patients with an available donor is the only current curative therapy. Other patients may receive immunosuppression, most commonly with anti-thymocyte globulin and cyclosporin. An initial response to immunosuppression is often encouraging, but relapse is common. Supportive care, including management of transfusion requirements and infections, is central to management. Promising new diagnostic tools and emerging therapies will likely transform approaches to this important, chronic and life-threatening condition.

Culturally and linguistically diverse (CALD) students enrolled in a Masters programs at an Australian university are often invisible or less visible in class; however, what is visible is their academic practice, which is often viewed as a deficit. Instead of comprehending how CALD students can become productive members of a community, research regularly examines ways to upgrade their academic literacy practices. This study contends that these students have much to offer, and if these students are to be considered valuable members of the higher education context, the learning community needs to perceive their difference as positive. This implies going beyond the institutional assessment of their academic practice as deficit and examining spaces of learning as rhizomatic. Drawing on the theory of Deleuze and Guattari, this study highlights how the process of becoming for the students and the teacher teaching them is never static, but is one constituted of deterritorialization and subsequent reterritorialization, resulting in the rhizomatic principle of variegated subjectivity. Data collected over two years illustrated how, for the researcher/ teacher, molecular level difference was possible within the molar level academic expectations. Themes of being and becoming and rhizomatic reimaginations demonstrated the desire of the students to achieve as a positive attempt to celebrate their difference, and, for the researcher, her academic positionality as a fluid, ongoing process where the molar and the molecular interact to illustrate teaching as a productive venture.

Objective: To assess the frequency of additional care, and parents' perceptions of quality, respectful care, in pregnancies subsequent to stillbirth. Design: Multi‐language web‐based survey. Setting: International. Population: A total of 2716 parents, from 40 high‐ and middle‐income countries. Methods: Data were obtained from a broader survey of parents' experiences following stillbirth. Data were analysed using descriptive statistics and stratified by geographic region. Subgroup analyses explored variation in additional care by gestational age at index stillbirth. Main outcome measures: Frequency of additional care, and perceptions of quality, respectful care. Results: The majority (66%) of parents conceived their subsequent pregnancy within 1 year of stillbirth. Additional antenatal care visits and ultrasound scans were provided for 67% and 70% of all parents, respectively, although there was wide variation across geographic regions. Care addressing psychosocial needs was less frequently provided, such as additional visits to a bereavement counsellor (10%) and access to named care provider's phone number (27%). Compared with parents whose stillbirth occurred at ≤ 29 weeks of gestation, parents whose stillbirth occurred at ≥ 30 weeks of gestation were more likely to receive various forms of additional care, particularly the option for early delivery after 37 weeks. Around half (47-63%) of all parents felt that elements of quality, respectful care were consistently applied, such as spending enough time with parents and involving parents in decision‐making. Conclusions: Greater attention is required to providing thoughtful, empathic and collaborative care in all pregnancies following stillbirth. Specific education and training for health professionals is needed.

BACKGROUND: Multiple sclerosis (MS) is a complex, demyelinating disease of the central nervous system. Fatigue is commonly reported by people with MS (PwMS). MS-related fatigue severely affects daily activities, employment, socioeconomic status, and quality of life. OBJECTIVE: We conducted this systematic review and meta-analysis to determine whether psychological interventions are effective in managing fatigue in PwMS. DATA SOURCES: We performed systematic searches of Medline, EMBASE, PsycINFO, and CINAHL to identify relevant articles published from database inception to April 5, 2017. Reference lists from relevant reviews were also searched. STUDY SELECTION AND DESIGN: Two independent reviewers screened the papers, extracted data, and appraised the included studies. A clinical psychologist verified whether interventions were psychological approaches. A narrative synthesis was conducted for all included studies. For relevant randomized controlled trials that reported sufficient information to determine standardized mean differences (SMDs) and 95% confidence intervals (CIs), meta-analyses were conducted using a random-effects model. RESULTS: Of the 353 identified articles, 20 studies with 1,249 PwMS were included in this systematic review. Narrative synthesis revealed that psychological interventions reduced fatigue in PwMS. Meta-analyses revealed that cognitive behavioral therapy decreased levels of fatigue compared with non-active controls (SMD = -0.32; 95% CI: -0.63 to -0.01) and compared with active controls (relaxation or psychotherapy) (SMD = -0.71; 95% CI: -1.05 to -0.37). Meta-analyses further showed that both relaxation (SMD = -0.90; 95% CI: -1.30 to -0.51), and mindfulness interventions (SMD = -0.62; 95% CI: -1.12 to -0.12), compared with non-active control, decreased fatigue levels. The estimates of heterogeneity for the four meta-analyses varied between none and moderate. CONCLUSION: This study found that the use of psychological interventions for MS-rel

Objective: To assess the frequency of additional care, and parents' perceptions of quality, respectful care, in pregnancies subsequent to stillbirth. Design: Multi‐language web‐based survey. Setting: International. Population: A total of 2716 parents, from 40 high‐ and middle‐income countries. Methods: Data were obtained from a broader survey of parents' experiences following stillbirth. Data were analysed using descriptive statistics and stratified by geographic region. Subgroup analyses explored variation in additional care by gestational age at index stillbirth. Main outcome measures: Frequency of additional care, and perceptions of quality, respectful care. Results: The majority (66%) of parents conceived their subsequent pregnancy within 1 year of stillbirth. Additional antenatal care visits and ultrasound scans were provided for 67% and 70% of all parents, respectively, although there was wide variation across geographic regions. Care addressing psychosocial needs was less frequently provided, such as additional visits to a bereavement counsellor (10%) and access to named care provider's phone number (27%). Compared with parents whose stillbirth occurred at ≤ 29 weeks of gestation, parents whose stillbirth occurred at ≥ 30 weeks of gestation were more likely to receive various forms of additional care, particularly the option for early delivery after 37 weeks. Around half (47-63%) of all parents felt that elements of quality, respectful care were consistently applied, such as spending enough time with parents and involving parents in decision‐making. Conclusions: Greater attention is required to providing thoughtful, empathic and collaborative care in all pregnancies following stillbirth. Specific education and training for health professionals is needed.

The availability of allergen molecules ('components') from several protein families has advanced our understanding of immunoglobulin E (IgE)-mediated responses and enabled 'component-resolved diagnosis' (CRD). The European Academy of Allergy and Clinical Immunology (EAACI) Molecular Allergology User's Guide (MAUG) provides comprehensive information on important allergens and describes the diagnostic options using CRD. Part A of the EAACI MAUG introduces allergen molecules, families, composition of extracts, databases, and diagnostic IgE, skin, and basophil tests. Singleplex and multiplex IgE assays with components improve both sensitivity for low-abundance allergens and analytical specificity; IgE to individual allergens can yield information on clinical risks and distinguish cross-reactivity from true primary sensitization. Part B discusses the clinical and molecular aspects of IgE-mediated allergies to foods (including nuts, seeds, legumes, fruits, vegetables, cereal grains, milk, egg, meat, fish, and shellfish), inhalants (pollen, mold spores, mites, and animal dander), and Hymenoptera venom. Diagnostic algorithms and short case histories provide useful information for the clinical workup of allergic individuals targeted for CRD. Part C covers protein families containing ubiquitous, highly cross-reactive panallergens from plant (lipid transfer proteins, polcalcins, PR-10, profilins) and animal sources (lipocalins, parvalbumins, serum albumins, tropomyosins) and explains their diagnostic and clinical utility. Part D lists 100 important allergen molecules. In conclusion, IgE-mediated reactions and allergic diseases, including allergic rhinoconjunctivitis, asthma, food reactions, and insect sting reactions, are discussed from a novel molecular perspective. The EAACI MAUG documents the rapid progression of molecular allergology from basic research to its integration into clinical practice, a quantum leap in the management of allergic patients.

BACKGROUND: Consistent performance of allergen assays is essential to ensure reproducibility of exposure assessments for investigations of asthma and occupational allergic disease. This study evaluated intra- and inter-laboratory reproducibility of a fluorescent multiplex array, which simultaneously measures eight indoor allergens in a single reaction well. METHODS: A multi-center study was performed in nine laboratories in the US and Europe to determine the inter-laboratory variability of an 8-plex array for dust mite, cat, dog, rat, mouse and cockroach allergens. Aliquots of 151 dust extract samples were sent to participating centers and analyzed by each laboratory on three separate occasions. Agreement within and between laboratories was calculated by the concordance correlation coefficient (CCC). RESULTS: Results were obtained for over 32,000 individual allergen measurements. Levels covered a wide range for all allergens from below the lower limit of detection (LLOD = 0.1-9.8 ng/ml) to higher than 6800 ng/ml for all allergens except Mus m 1, which was up to 1700 ng/ml. Results were reproducible within as well as between laboratories. Within laboratories, 94% of CCC were ≥ 0.90, and 80% of intra-laboratory results fell within a 10% coefficient of variance (CV%). Results between laboratories also showed highly significant positive correlations for all allergens (~0.95, p

We report the first evidence of artificial ionospheric plasmas reaching sufficient density to sustain interaction with a high-power HF pump beam produced by the 3.6 MW High-Frequency Active Auroral Program (HAARP) transmitter in Gakona, Alaska. The HF-driven ionization process is initiated near the 2nd electron gyroharmonic at 220 km altitude in the ionospheric F region. Once the artificial plasma reaches sufficient density to support interaction with the transmitter beam it rapidly descends as an ionization wave to approximately 150 km altitude. Although these initial artificial layers appear to be dynamic and highly structured, this new ability to produce significant artificial plasma in the upper atmosphere opens the door to a new regime in ionospheric radio wave propagation where transmitter-produced plasmas dominate over the natural ionospheric plasma and may eventually be employed as active components of communications, radar, and other systems., Published in Geophysical Research Letters, v37 L02106, 30 Jan 2010. Sponsored in part AFOSR.

The multitask objectives of the plan discussed in this proposal are to research the role and effects of fretting on structural life of components; develop and demonstrate the feasibility of integrating candidate fretting fatigue predictive analytic model(s) into structural integrity methods; integrate and implement the techniques for applications to present and future U.S. military weapons programs, commercial aviation, automotive, and mechanical equipment; and provide industry access to the predictive tools and information for commercialization., Report contains color, The original document contains color images.

In this report, an Equivalent Crack Size (ECS) approach is assessed and implemented for corrosion pittIng in D6ac steel. Relationships between physical corrosion morphology and fatigue life of laboratory coupons were established that allowed corrosion pits to be described as cracks to provide input for durability and damage tolerance analyses. Using the ECS relationship, fatigue lives were accurately predicted in complex coupons tested under spectrum loading. Details are provided on all the corrosion procedures, the developmental testing program, and the validation testing program. So far, the ECS model for corrosion pitting is only valid for areas of the structure that do not experience yielding. Examination of the application of ECS to cases that experience compressive and tensile yield, awaits final development of the appropriate analysis software. The impact of this research on F-ill fleet management can be quite positive by helping avoid unnecessary maintenance and helping to reach a life-of-type goal of 2020.

Purpose: The purpose of the study is to develop an outcome measurement tool to investigate functional performance of consumers using seating and wheelchair systems as their primary seating and mobility device. The instrument is undergoing systematic development in three phases. The results of Phase 1 will be reported. Method: Manual and power wheelchair users were interviewed using a modified version of a client-centred outcome measure. An item bank was derived based on the interview data. Subjects were then asked to validate item categories of the new instrument, and finally to self-administer the first version of the instrument. Results: Subjects reported 154 self-care, productivity, and leisure occupational performance issues related to their current seating-mobility system. Based on their input, 10 categories (i.e. transfers, reach, accessing task surfaces, transportation-portability, human-machine interface, architectural barriers, transportation-accessibility, transportation-securement, natural barriers and accessories) were validated for inclusion in the new outcome measure, Functional Evaluation in a Wheelchair (FEW). Conclusion: The items on the FEW focus on the interaction between the consumer, the technology, and the milieu. Consumers viewed the overall importance of FEW categories for seating-mobility system users differently than when they self-administered the FEW.

Purpose: The purpose of the study is to develop an outcome measurement tool to investigate functional performance of consumers using seating and wheelchair systems as their primary seating and mobility device. The instrument is undergoing systematic development in three phases. The results of Phase 1 will be reported. Method: Manual and power wheelchair users were interviewed using a modified version of a client-centred outcome measure. An item bank was derived based on the interview data. Subjects were then asked to validate item categories of the new instrument, and finally to self-administer the first version of the instrument. Results: Subjects reported 154 self-care, productivity, and leisure occupational performance issues related to their current seating-mobility system. Based on their input, 10 categories (i.e. transfers, reach, accessing task surfaces, transportation-portability, human-machine interface, architectural barriers, transportation-accessibility, transportation-securement, natural barriers and accessories) were validated for inclusion in the new outcome measure, Functional Evaluation in a Wheelchair (FEW). Conclusion: The items on the FEW focus on the interaction between the consumer, the technology, and the milieu. Consumers viewed the overall importance of FEW categories for seating-mobility system users differently than when they self-administered the FEW.

The RAAF is now the sole operator of the F-111 and current plans for the fleet will keep the aircraft in service until 2020. The F-111 is a structurally complex aircraft, and its swing-wing geometry in particular requires materials of ultra high strength to handle expected loadings. In particular, the D6ac steel used in most of the critical components in the aircraft was subjected to rigorous research efforts in the early 1970s to better characterise material performance in fatigue. This report summarises many of these efforts to characterise the main alloys in the airframe, namely: D6ac steel and aluminium alloys 2024-T851, 7079-T651, and 7075-T6. The major goal is to study the available data for these critical F-111 materials, evaluate the completeness of the existing data sets and make recommendations for research efforts necessary to ensure that the F-111 fleet is operated as safely and economically as possible until retired. Particular attention is payed to the fact that the RAAF now uses JP-8 fuel rather than the original JP-4 fuel. Short crack behaviour from corrosion damage will likely be a concern for the F-111, particularly in the D6ac steel. Stress corrosion cracking is likely to continue to be the biggest problem for the 7xxx-series aluminium alloy components and will have to be monitored carefully.

Nine projects were established by the Army through the University Research Initiative (URI) Program and two projects were established by the Army outside the URI Program. Six projects were established by the Congress as set-asides in DOD appropriations laws and are administered by the Army, Defense Nuclear Agency, or the Defense Advanced Research Projects Agency. These 17 projects were funded in three major areas: (1) research, (2) equipment, and (3) fellowships. Research-related costs comprised the majority of funding for 15 projects. Expenditure data was not available for the other two projects that were recently established by congressional set-asides. Total cumulative expenditures identified by the universities for 15 of the 17 projects as of September 30, 1989, were approximately $62 million. The amount of funding provided to universities for fellowship and equipment grants was approximately $22 million. A primary purpose of DOD's oversight of university research is to examine the relevance of research to its needs and to minimize or prevent duplication. The Army, for example, questioned the relevance of some of the research topics being pursued under one URI project and recommended refocusing certain research on another project., Report to Subcommittee on Research and Development and Committee on Armed Services, House of Representatives.

The objective of this work is to develop a high speed (gigasampling rate per second range) multibit A/D converter based on the characteristics of GaAs transferred-electron logic devices (TELD) and the monolithic GaAs IC technology developed at TRW. The TELD is a threshold device which has been used in conjunction with a FET comparator circuit in a successive approximation or serial A/D converter. In orde to make consideration of the delay path in the matching between the A/D cells manageable, a low frequency direct coupling approach was adopted for a 5-bit three gigasample per second A/D converter. Following this approach, an optimized computer-aided design and a complete circuit layout has been accomplished. (Author)

Parabolic rate constants of the reaction of chromium with nitrogen gas under oxygen-free conditions have been determined over a range of temperature (1000-1250 C) and nitrogen pressure (0.265-101.33 kPa). The growth rate of the subnitride was measured by a thermogravimetric technique using a single specimen. Wagner's oxidation theory is used to calculate the self-diffusivity and intrinsic diffusivity of nitrogen in the subnitride from a theoretical analysis of the parabolic rate constant. The calculated diffusivities varied with the composition of the subnitride, having minimum values at intermediate compositions of the non-stoichiometric chromium nitride Cr2N.

A slow-speed high frequency reciprocating test rig was used to investigate the behavior of a lubricated sliding contact when subjected to repeated slow-speed passes within times comparable to the reaction rates of chemically acting lubricant additives. Such conditions are similar to the working environment of a lubircant and tests carried out using this test rig are shown to reveal more information than may be obtained otherwise. The report presents a brief description of the test rig and the results of tests made on a series of ammeline and teflon greases using this new method. The results of tests on a commercial mineral oil are also included. (Author)

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This research was carried out to build on previous work regarding the drivers and diffusion patterns of ISO 9001/14001 global standards, designed by the International Organisation for Standardisation to set a benchmark for quality and environmental management systems respectively. The research looks to identify a link between total GDP growth in chosen economies and what affect this has on the uptake of the ISO 9001/14001 certifications and if successful will aid in the prediction of future ISO standards’ growth or decline. The economies focused on are those that are listed by ISO as the countries with the top ten highest numbers of ISO 9001 and ISO 14001 certifications, with China, Italy, Japan, Spain, Germany, UK, USA and South Korea appearing in both lists, Russia and India in the ISO 9001 top ten only, and Romania and the Czech Republic in the ISO 14001 top ten only. The countries were analysed using a combination of visual graphical evidence and Pearson’s correlation coefficients estimates and it was found that those countries with developing economies showed a trend towards a relationship between increased total GDP growth and increased certifications, whereas developed economies with slower total GDP growth showed a propensity for saturating or falling levels of certifications. The results of this study aid as an introduction to a new area of research and can be used as the basis for research of greater scope in terms of time-frame and economies analysed. Keywords: ISO 9001, ISO 14001, GDP, certification, growth