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1. Chancen und Herausforderungen hausärztlicher Fortbildung - ein europäischer Vergleich

Author

Löffler, C, Altiner, A, Blumenthal, S, Bruno, P, de Sutter, A, de Vos, B, Dinant, GJ, Duerden, M, Dunais, B, Egidi, G, Gibis, B, Melbye, H, Rouquier, F, Rosemann, T, Touboul-Lundgren, P, Feldmeier, G, Löffler, C, Altiner, A, Blumenthal, S, Bruno, P, de Sutter, A, de Vos, B, Dinant, GJ, Duerden, M, Dunais, B, Egidi, G, Gibis, B, Melbye, H, Rouquier, F, Rosemann, T, Touboul-Lundgren, P, and Feldmeier, G

Published
2022

2. Chancen und Herausforderungen hausärztlicher Fortbildung - ein europäischer Vergleich

Author

Löffler, C, Altiner, A, Blumenthal, S, Bruno, P, de Sutter, A, de Vos, B, Dinant, GJ, Duerden, M, Dunais, B, Egidi, G, Gibis, B, Melbye, H, Rouquier, F, Rosemann, T, Touboul-Lundgren, P, Feldmeier, G, Löffler, C, Altiner, A, Blumenthal, S, Bruno, P, de Sutter, A, de Vos, B, Dinant, GJ, Duerden, M, Dunais, B, Egidi, G, Gibis, B, Melbye, H, Rouquier, F, Rosemann, T, Touboul-Lundgren, P, and Feldmeier, G

Published
2022

3. Effects of internet-based training on antibiotic prescribing rates for acute respiratory-tract infections: a multinational, cluster, randomised, factorial, controlled trial.

Author

Little, P., Stuart, B., Francis, N., Douglas, E., Tonkin-Crine, S., Anthierens, S., Cals, J.W.L., Melbye, H., Santer, M., Moore, M., Coenen, S., Butler, C., Hood, K., Kelly, M., Godycki-Cwirko, M., Mierzecki, A., Torres, A., Llor, C., Davies, M, Mullee, M., O'Reilly, G., van der Velden, A.W., Geraghty, A.W.A., Goossens, H., Verheij, Th.J.M., Yardley, L., Little, P., Stuart, B., Francis, N., Douglas, E., Tonkin-Crine, S., Anthierens, S., Cals, J.W.L., Melbye, H., Santer, M., Moore, M., Coenen, S., Butler, C., Hood, K., Kelly, M., Godycki-Cwirko, M., Mierzecki, A., Torres, A., Llor, C., Davies, M, Mullee, M., O'Reilly, G., van der Velden, A.W., Geraghty, A.W.A., Goossens, H., Verheij, Th.J.M., and Yardley, L.

Published
2013

6. Effects of internet-based training on antibiotic prescribing rates for acute respiratory-tract infections: a multinational, cluster, randomised, factorial, controlled trial.

Author

Little, P., Stuart, B., Francis, N., Douglas, E., Tonkin-Crine, S., Anthierens, S., Cals, J.W.L., Melbye, H., Santer, M., Moore, M., Coenen, S., Butler, C., Hood, K., Kelly, M., Godycki-Cwirko, M., Mierzecki, A., Torres, A., Llor, C., Davies, M, Mullee, M., O'Reilly, G., van der Velden, A.W., Geraghty, A.W.A., Goossens, H., Verheij, Th.J.M., Yardley, L., Little, P., Stuart, B., Francis, N., Douglas, E., Tonkin-Crine, S., Anthierens, S., Cals, J.W.L., Melbye, H., Santer, M., Moore, M., Coenen, S., Butler, C., Hood, K., Kelly, M., Godycki-Cwirko, M., Mierzecki, A., Torres, A., Llor, C., Davies, M, Mullee, M., O'Reilly, G., van der Velden, A.W., Geraghty, A.W.A., Goossens, H., Verheij, Th.J.M., and Yardley, L.

Published
2013

7. Effects of internet-based training on antibiotic prescribing rates for acute respiratory-tract infections: a multinational, cluster, randomised, factorial, controlled trial.

Author

Little, P., Stuart, B., Francis, N., Douglas, E., Tonkin-Crine, S., Anthierens, S., Cals, J.W.L., Melbye, H., Santer, M., Moore, M., Coenen, S., Butler, C., Hood, K., Kelly, M., Godycki-Cwirko, M., Mierzecki, A., Torres, A., Llor, C., Davies, M, Mullee, M., O'Reilly, G., van der Velden, A.W., Geraghty, A.W.A., Goossens, H., Verheij, Th.J.M., Yardley, L., Little, P., Stuart, B., Francis, N., Douglas, E., Tonkin-Crine, S., Anthierens, S., Cals, J.W.L., Melbye, H., Santer, M., Moore, M., Coenen, S., Butler, C., Hood, K., Kelly, M., Godycki-Cwirko, M., Mierzecki, A., Torres, A., Llor, C., Davies, M, Mullee, M., O'Reilly, G., van der Velden, A.W., Geraghty, A.W.A., Goossens, H., Verheij, Th.J.M., and Yardley, L.

Published
2013

10. Primary care clinicians' perceptions of antibiotic resistance: a multi-country qualitative interview study.

Author

Infection & Immunity, JC onderzoeksprogramma Infectieziekten, General Practice & Nursing Science, Wood, F., Philips, C., Brookes-Howell, L., Hood, K., Verheij, Th.J.M., Coenen, S., Little, P., Melbye, H., Godycki-Cwirko, M., Jakobsen, K., Worby, P., Goossens, H., Butler, C.C., Infection & Immunity, JC onderzoeksprogramma Infectieziekten, General Practice & Nursing Science, Wood, F., Philips, C., Brookes-Howell, L., Hood, K., Verheij, Th.J.M., Coenen, S., Little, P., Melbye, H., Godycki-Cwirko, M., Jakobsen, K., Worby, P., Goossens, H., and Butler, C.C.

Published
2013

11. Effects of internet-based training on antibiotic prescribing rates for acute respiratory-tract infections: a multinational, cluster, randomised, factorial, controlled trial

Author

Infection & Immunity, JC onderzoeksprogramma Infectieziekten, General Practice & Nursing Science, Little, P., Stuart, B., Francis, N., Douglas, E., Tonkin-Crine, S., Anthierens, S., Cals, J.W.L., Melbye, H., Santer, M., Moore, M., Coenen, S., Butler, C., Hood, K., Kelly, M., Godycki-Cwirko, M., Mierzecki, A., Torres, A., Llor, C., Davies, M, Mullee, M., O'Reilly, G., van der Velden, A.W., Geraghty, A.W.A., Goossens, H., Verheij, Th.J.M., Yardley, L., Infection & Immunity, JC onderzoeksprogramma Infectieziekten, General Practice & Nursing Science, Little, P., Stuart, B., Francis, N., Douglas, E., Tonkin-Crine, S., Anthierens, S., Cals, J.W.L., Melbye, H., Santer, M., Moore, M., Coenen, S., Butler, C., Hood, K., Kelly, M., Godycki-Cwirko, M., Mierzecki, A., Torres, A., Llor, C., Davies, M, Mullee, M., O'Reilly, G., van der Velden, A.W., Geraghty, A.W.A., Goossens, H., Verheij, Th.J.M., and Yardley, L.

Published
2013

12. Are Patient Views about Antibiotics Related to Clinician Perceptions, Management and Outcome? A Multi-Country Study in Outpatients with Acute Cough

Author

Infection & Immunity, JC onderzoeksprogramma Infectieziekten, General Practice & Nursing Science, Coenen, S., Francis, N.K., Kelly, M.J., Hood, K., Nuttall, J., Little, P., Verheij, Th.J.M., Melbye, H., Goossens, H., Grace Project Group, x, Butler, C.C., Infection & Immunity, JC onderzoeksprogramma Infectieziekten, General Practice & Nursing Science, Coenen, S., Francis, N.K., Kelly, M.J., Hood, K., Nuttall, J., Little, P., Verheij, Th.J.M., Melbye, H., Goossens, H., Grace Project Group, x, and Butler, C.C.

Published
2013

13. Antibiotic prescribing for discoloured sputum in acute cough/lower respiratory tract infection

Author

Butler, C.C., Kelly, M.J., Hood, K., Schaberg, T., Melbye, H., Serra-Prat, M., Blasi, F., Little, P., Verheij, T., Mölstad, Sigvard, Godycki-Cwirko, M., Edwards, P., Almirall, J., Torres, A., Rautakorpi, U-M., Nuttall, J., Goossens, H., Coenen, S., Butler, C.C., Kelly, M.J., Hood, K., Schaberg, T., Melbye, H., Serra-Prat, M., Blasi, F., Little, P., Verheij, T., Mölstad, Sigvard, Godycki-Cwirko, M., Edwards, P., Almirall, J., Torres, A., Rautakorpi, U-M., Nuttall, J., Goossens, H., and Coenen, S.

Abstract

We investigated whether discoloured sputum and feeling unwell were associated with antibiotic prescription and benefit from antibiotic treatment for acute cough/lower respiratory tract infection (LTRI) in a prospective study of 3,402 adults in 13 countries. A two-level model investigated the association between producing discoloured sputum or feeling generally unwell and an antibiotic prescription. A three-level model investigated the association between an antibiotic prescription and symptom resolution. Patients producing discoloured sputum were prescribed antibiotics more frequently than those not producing sputum (OR 3.2, 95% CI 2.1-5.0), unlike those producing clear/white sputum (OR 0.95, 95% CI 0.61-1.48). Antibiotic prescription was not associated with a greater rate or magnitude of symptom score resolution (as measured by a 13-item questionnaire completed by patients each day) among those who: produced yellow (coefficient 0.00; p=0.68) or green (coefficient -0.01; p=0.11) sputum; reported any of three categories of feeling unwell; or produced discoloured sputum and felt generally unwell (coefficient -0.01; p=0.19). Adults with acute cough/LRTI presenting in primary care settings with discoloured sputum were prescribed antibiotics more often compared to those not producing sputum. Sputum colour, alone or together with feeling generally unwell, was not associated with recovery or benefit from antibiotic treatment.

Published
2011
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14. Variation in antibiotic prescribing and its impact on recovery in patients with acute cough in primary care : Prospective study in 13 countries

Author

Butler, C.C., Hood, K., Verheij, T., Little, P., Melbye, H., Nuttall, J., Kelly, M.J., Molstad, S., Godycki-Cwirko, M., Almirall, J., Torres, A., Gillespie, D., Rautakorpi, U., Coenen, S., Goossens, H., Butler, C.C., Hood, K., Verheij, T., Little, P., Melbye, H., Nuttall, J., Kelly, M.J., Molstad, S., Godycki-Cwirko, M., Almirall, J., Torres, A., Gillespie, D., Rautakorpi, U., Coenen, S., and Goossens, H.

Abstract

Objective: To describe variation in antibiotic prescribing for acute cough in contrasting European settings and the impact on recovery. Design: Cross sectional observational study with clinicians from 14 primary care research networks in 13 European countries who recorded symptoms on presentation and management. Patients followed up for 28 days with patient diaries. Setting: Primary care. Participants: Adults with a new or worsening cough or clinical presentation suggestive of lower respiratory tract infection. Main outcome measures: Prescribing of antibiotics by clinicians and total symptom severity scores over time. Results: 3402 patients were recruited (clinicians completed a case report form for 99% (3368) of participants and 80% (2714) returned a symptom diary). Mean symptom severity scores at presentation ranged from 19 (scale range 0 to 100) in networks based in Spain and Italy to 38 in the network based in Sweden. Antibiotic prescribing by networks ranged from 20% to nearly 90% (53% overall), with wide variation in classes of antibiotics prescribed. Amoxicillin was overall the most common antibiotic prescribed, but this ranged from 3% of antibiotics prescribed in the Norwegian network to83% in the English network. While fluoroquinolones were not prescribed at all in three networks, they were prescribed for 18% in the Milan network. After adjustment for clinical presentation and demographics, considerable differences remained in antibiotic prescribing, ranging from Norway (odds ratio 0.18, 95% confidence interval 0.11 to 0.30) to Slovakia (11.2, 6.20 to 20.27) compared with the overall mean (proportion prescribed: 0.53). The rate of recovery was similar for patients who were and were not prescribed antibiotics (coefficient -0.01, Pless than0.01) once clinical presentation was taken into account. Conclusions: Variation in clinical presentation does not explain the considerable variation in antibiotic prescribing for acute cough in Europe. Variation in antibiot

Published
2009
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15. Variation in antibiotic prescribing and its impact on recovery in patients with acute cough in primary care : Prospective study in 13 countries

Author

Butler, C.C., Hood, K., Verheij, T., Little, P., Melbye, H., Nuttall, J., Kelly, M.J., Molstad, S., Godycki-Cwirko, M., Almirall, J., Torres, A., Gillespie, D., Rautakorpi, U., Coenen, S., Goossens, H., Butler, C.C., Hood, K., Verheij, T., Little, P., Melbye, H., Nuttall, J., Kelly, M.J., Molstad, S., Godycki-Cwirko, M., Almirall, J., Torres, A., Gillespie, D., Rautakorpi, U., Coenen, S., and Goossens, H.

Abstract

Objective: To describe variation in antibiotic prescribing for acute cough in contrasting European settings and the impact on recovery. Design: Cross sectional observational study with clinicians from 14 primary care research networks in 13 European countries who recorded symptoms on presentation and management. Patients followed up for 28 days with patient diaries. Setting: Primary care. Participants: Adults with a new or worsening cough or clinical presentation suggestive of lower respiratory tract infection. Main outcome measures: Prescribing of antibiotics by clinicians and total symptom severity scores over time. Results: 3402 patients were recruited (clinicians completed a case report form for 99% (3368) of participants and 80% (2714) returned a symptom diary). Mean symptom severity scores at presentation ranged from 19 (scale range 0 to 100) in networks based in Spain and Italy to 38 in the network based in Sweden. Antibiotic prescribing by networks ranged from 20% to nearly 90% (53% overall), with wide variation in classes of antibiotics prescribed. Amoxicillin was overall the most common antibiotic prescribed, but this ranged from 3% of antibiotics prescribed in the Norwegian network to83% in the English network. While fluoroquinolones were not prescribed at all in three networks, they were prescribed for 18% in the Milan network. After adjustment for clinical presentation and demographics, considerable differences remained in antibiotic prescribing, ranging from Norway (odds ratio 0.18, 95% confidence interval 0.11 to 0.30) to Slovakia (11.2, 6.20 to 20.27) compared with the overall mean (proportion prescribed: 0.53). The rate of recovery was similar for patients who were and were not prescribed antibiotics (coefficient -0.01, Pless than0.01) once clinical presentation was taken into account. Conclusions: Variation in clinical presentation does not explain the considerable variation in antibiotic prescribing for acute cough in Europe. Variation in antibiot

Published
2009
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