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1. Impact of CRT-D implantation on clinical outcomes and healthcare resource utilization: an Italian cohort study

Author

Landolina, M, Madotto, F, Mantovani, L, Lunati, M, Achilli, F, Curnis, A, Marzegalli, M, Procclemer, A, Fornari, C, Cesana, G, Landolina M, Madotto F, Mantovani LG, Lunati M, Achilli F, Curnis A, Marzegalli M, Procclemer A, Fornari C, Cesana G., Landolina, M, Madotto, F, Mantovani, L, Lunati, M, Achilli, F, Curnis, A, Marzegalli, M, Procclemer, A, Fornari, C, Cesana, G, Landolina M, Madotto F, Mantovani LG, Lunati M, Achilli F, Curnis A, Marzegalli M, Procclemer A, Fornari C, and Cesana G.

Published
2016

2. Impact of ICD/CRT-D implantation on healthcare resources utilization: an Italian cohort study.

Author

Landolina, M, Lunati, M, Madotto, F, Conti, S, Chiodini, V, Mantovani, L, Achilli, F, Curnis, A, Marzegalli, M, Proclemer, A, Fornari, C, Giancarlo, G, Lunati M, Madotto F, Conti S, Chiodini V, Mantovani LG, Achilli F, Curnis A, Marzegalli M, Proclemer A, Fornari C, Giancarlo G.C., Landolina, M, Lunati, M, Madotto, F, Conti, S, Chiodini, V, Mantovani, L, Achilli, F, Curnis, A, Marzegalli, M, Proclemer, A, Fornari, C, Giancarlo, G, Lunati M, Madotto F, Conti S, Chiodini V, Mantovani LG, Achilli F, Curnis A, Marzegalli M, Proclemer A, Fornari C, and Giancarlo G.C.

Published
2016

3. Remote monitoring reduces healthcare utilization and improbe quality of care in heart failure patients with implantable defribillators: the EVOLVO (Evolution of Management Strategies of Heart Failure Patients with Implantable Defribillators) Study

Author

Landolina, M, Perego, G, Lunati, M, Curnis, A, Guenzati, G, Vicentini, A, Parati, G, Borghi, G, Zanaboni, P, Valsecchi, S, Marzegalli, M, Perego, GB, Marzegalli, M., PARATI, GIANFRANCO, Landolina, M, Perego, G, Lunati, M, Curnis, A, Guenzati, G, Vicentini, A, Parati, G, Borghi, G, Zanaboni, P, Valsecchi, S, Marzegalli, M, Perego, GB, Marzegalli, M., and PARATI, GIANFRANCO

Abstract

Background—Heart failure patients with implantable cardioverter-defibrillators (ICDs) or an ICD for resynchronization therapy often visit the hospital for unscheduled examinations, placing a great burden on healthcare providers. We hypothesized that Internet-based remote interrogation systems could reduce emergency healthcare visits. Methods and Results—This multicenter randomized trial involving 200 patients compared remote monitoring with standard patient management consisting of scheduled visits and patient response to audible ICD alerts. The primary end point was the rate of emergency department or urgent in-office visits for heart failure, arrhythmias, or ICD-related events. Over 16 months, such visits were 35% less frequent in the remote arm (75 versus 117; incidence density, 0.59 versus 0.93 events per year; P 0.005). A 21% difference was observed in the rates of total healthcare visits for heart failure, arrhythmias, or ICD-related events (4.40 versus 5.74 events per year; P 0.001). The time from an ICD alert condition to review of the data was reduced from 24.8 days in the standard arm to 1.4 days in the remote arm (P 0.001). The patients’ clinical status, as measured by the Clinical Composite Score, was similar in the 2 groups, whereas a more favorable change in quality of life (Minnesota Living With Heart Failure Questionnaire) was observed from the baseline to the 16th month in the remote arm (P 0.026). Conclusions—Remote monitoring reduces emergency department/urgent in-office visits and, in general, total healthcare use in patients with ICD or defibrillators for resynchronization therapy. Compared with standard follow-up through in-office visits and audible ICD alerts, remote monitoring results in increased efficiency for healthcare providers and improved quality of care for patients.

Published
2012

4. Continuity of care in patients with cardiac failure after acute event [Percorsi e continuità assistenziale nel paziente con scompenso cardiaco dopo evento acuto]

Author

Tridico, C, Fontana, G, Diaco, T, Oliva, F, Giordano, A, Senni, M, Filippi, A, Marzegalli, M, Fiorini, G, Ambrosetti, M, Febo, O, Commissione Cardiocerebrovascolare, Sottocommissione, Tridico C, Fontana G, Diaco T, Oliva F, Giordano A, Senni M, Filippi A, Marzegalli M, Fiorini G, Ambrosetti M, Febo O, Tridico, C, Fontana, G, Diaco, T, Oliva, F, Giordano, A, Senni, M, Filippi, A, Marzegalli, M, Fiorini, G, Ambrosetti, M, Febo, O, Commissione Cardiocerebrovascolare, Sottocommissione, Tridico C, Fontana G, Diaco T, Oliva F, Giordano A, Senni M, Filippi A, Marzegalli M, Fiorini G, Ambrosetti M, and Febo O

Published
2010

6. The Economic Impact of The use of Implantable Cardioverter Defibrillator In Primary Prevention

Author

Madotto, F, Conti, S, Chiodini, V, Mantovani, L, Achilli, F, Curnis, A, Landolina, M, Lunati, M, Marzegalli, M, Proclemer, A, Fornari, C, Cesana, G, MADOTTO, FABIANA, CONTI, SARA, MANTOVANI, LORENZO GIOVANNI, FORNARI, CARLA, CESANA, GIANCARLO, Madotto, F, Conti, S, Chiodini, V, Mantovani, L, Achilli, F, Curnis, A, Landolina, M, Lunati, M, Marzegalli, M, Proclemer, A, Fornari, C, Cesana, G, MADOTTO, FABIANA, CONTI, SARA, MANTOVANI, LORENZO GIOVANNI, FORNARI, CARLA, and CESANA, GIANCARLO

Published
2015

7. The Economic Impact of The use of Implantable Cardioverter Defibrillator In Primary Prevention

Author

Madotto, F, Conti, S, Chiodini, V, Mantovani, L, Achilli, F, Curnis, A, Landolina, M, Lunati, M, Marzegalli, M, Proclemer, A, Fornari, C, Cesana, G, MADOTTO, FABIANA, CONTI, SARA, MANTOVANI, LORENZO GIOVANNI, FORNARI, CARLA, CESANA, GIANCARLO, Madotto, F, Conti, S, Chiodini, V, Mantovani, L, Achilli, F, Curnis, A, Landolina, M, Lunati, M, Marzegalli, M, Proclemer, A, Fornari, C, Cesana, G, MADOTTO, FABIANA, CONTI, SARA, MANTOVANI, LORENZO GIOVANNI, FORNARI, CARLA, and CESANA, GIANCARLO

Published
2015

8. PREDESTINATION: PRimary vEntricular fibrillation and suDden dEath during a firST myocardIal iNfArcTION: Genetic basis

Author

Grieco, N, Marzegalli, M, Paganoni, AM, De Ferrari, G, De Regibus, V, Gionti, V, Civardi, D, Insolia, R, Pedrazzini, M, Gentilini, D, Di Blasio, A, Crotti, L, Schwartz, P, De Ferrari GM, De Regibus V, Gionti V, Civardi D, Insolia R, Pedrazzini M, Gentilini D, Di Blasio A, Crotti L, Schwartz PJ, Grieco, N, Marzegalli, M, Paganoni, AM, De Ferrari, G, De Regibus, V, Gionti, V, Civardi, D, Insolia, R, Pedrazzini, M, Gentilini, D, Di Blasio, A, Crotti, L, Schwartz, P, De Ferrari GM, De Regibus V, Gionti V, Civardi D, Insolia R, Pedrazzini M, Gentilini D, Di Blasio A, Crotti L, and Schwartz PJ

Abstract

Sudden cardiac death (SCD) is the leading cause of death in the age group 20–65 years, in the western world, with an enormous social and economic impact. The majority of the cases of ventricular fibrillation (VF) occur in patients without a preexisting structural heart disease and represent the first manifestation of coronary artery disease. In most of these cases, VF occurs in the early phase of myocardial infarction (MI) and it is then called primary VF. Although several factors have been associated in various studies with primary VF a recent metaanalysis found no evidence for risk factors other than ST elevation and time from onset of symptoms. In the past several years, few studies have found that a family history of sudden cardiac death (SCD) is a risk factor for primary VF suggesting that this dramatic event may be favored by the genetic background. To explore this possibility we designed the ongoing PREDESTINATION Study, enrolling subjects under 75 years of age with a first MI complicated by primary VF and a control group of subjects with a first uncomplicated MI. Data so far available confirm the association between a family history of SCD and primary VF and suggest that hypokalemia and prolonged QT interval may favor its occurrence. The genetic analysis has already provided some interesting suggestions that will need to be confirmed by the continuation of the enrolment and joint analysis with data deriving from similar patient populations.

Published
2013

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