1. Physical activity and brain amyloid beta: A longitudinal analysis of cognitively unimpaired older adults
- Author
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Slee, Michael G., Rainey-Smith, Stephanie R., Villemagne, Victor L., Doecke, James D., Sohrabi, Hamid R., Taddei, Kevin, Ames, David, Dore, Vincent, Maruff, Paul, Laws, Simon M., Masters, Colin L., Rowe, Christopher C., Martins, Ralph N., Erickson, Kirk I., Brown, Belinda M., Slee, Michael G., Rainey-Smith, Stephanie R., Villemagne, Victor L., Doecke, James D., Sohrabi, Hamid R., Taddei, Kevin, Ames, David, Dore, Vincent, Maruff, Paul, Laws, Simon M., Masters, Colin L., Rowe, Christopher C., Martins, Ralph N., Erickson, Kirk I., and Brown, Belinda M.
- Abstract
Introduction: The current study evaluated the relationship between habitual physical activity (PA) levels and brain amyloid beta (A ) over 15 years in a cohort of cognitively unimpaired older adults. Methods: PA and A measures were collected over multiple timepoints from 731 cognitively unimpaired older adults participating in the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study of Aging. Regression modeling examined cross-sectional and longitudinal relationships between PA and brain A . Moderation analyses examined apolipoprotein E (APOE) 4 carriage impact on the PA-A relationship. Results: PA was not associated with brain A at baseline ( = –0.001, p = 0.72) or over time ( = –0.26, p = 0.24). APOE 4 status did not moderate the PA-A relationship over time ( = 0.12, p = 0.73). Brain A levels did not predict PA trajectory ( = –54.26, p = 0.59). Discussion: Our study did not identify a relationship between habitual PA and brain A levels. Highlights: Physical activity levels did not predict brain amyloid beta (A ) levels over time in cognitively unimpaired older adults ( ≥ 60 years of age). Apolipoprotein E (APOE) 4 carrier status did not moderate the physical activity–brain A relationship over time. Physical activity trajectories were not impacted by brain A levels.
- Published
- 2023