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Background: Patients with advanced type B3 thymoma and thymic carcinoma resistant to chemotherapy have few treatment options. We report the efficacy and safety results of the combination of the anti-PD-L1 inhibitor avelumab with the anti-angiogenesis drug axitinib in patients with advanced type B3 thymoma and thymic carcinoma. Methods: CAVEATT was a single-arm, multicentre, phase 2 trial, conducted in two Italian centres (the European Instituteof Oncology and the Humanitas Institute, Milan) in patients with histologically confirmed type B3 thymoma or thymic carcinoma, with advanced stage of disease who had progressed after at least one line of platinum-based chemotherapy. Previous treatment with an anti-angiogenesis drug was allowed but not with immune checkpoint inhibitors. Other inclusion criteria were age 18 years or older, an Eastern Cooperative Oncology Group performance status of 0–2, progressive disease, and presence of measurable disease according to Response Evaluation Criteria In Solid Tumours (RECIST) version 1.1. Patients received avelumab 10 mg/kg intravenously every 2 weeks and axitinib 5 mg orally twice daily until disease progression or unacceptable toxicity. The primary endpoint was the centrally assessed overall response rate according to RECIST version 1.1. Patients who received at least one cycle of treatment and had at least one CT scan after treatment start at scheduled time point by protocol were judged assessable for response and were included in efficacy and safety analyses. This study is registered with EUDRACT, 2017–004048–38; enrolment is completed and follow-up is ongoing. Findings: Between April 22, 2019, and June 30, 2021, 32 patients were enrolled. 27 patients had a thymic carcinoma, three a type B3 thymoma, and two a mixed type B3 thymoma and thymic carcinoma. 29 (91%) of 32 patients had stage IVB disease and 13 (41%) of 32 had been pretreated with an anti-angiogenesis drug. 11 of 32 patients had an overall response; thus the overall

We study the nature of the two-dimensional quantum critical point separating two phases with and without long-range spin-density-wave order, which has been recently observed in cuprate superconductors. We consider the Landau-Ginzburg-Wilson Hamiltonian associated with the spin-density critical modes, perform a mean-field analysis of the phase diagram, and study the corresponding renormalization-group flow in two different perturbative schemes at five and six loops, respectively. The analysis supports the existence of a stable fixed point in the full theory whose basin of attraction includes systems with collinear spin-density-wave order, as observed in experiments. The stable fixed point is characterized by an enlarged O(4)xO(3) symmetry. The continuous transition observed in experiments is expected to belong to this universality class. The corresponding critical exponents are nu = 0.9(2) and eta = 0.15(10).

We study the nature of the Helium-3 superfluid transition from the normal to the planar phase, which is expected to be stabilized by the dipolar interactions. We determine the RG flow of the corresponding Landau-Ginzburg-Wilson theory by exploiting two fixed-dimension perturbative schemes: the massive zero-momentum scheme and the minimal-subtraction scheme without $\epsilon$ expansion. The analysis of the corresponding six-loop and five-loop series shows the presence of a stable fixed point in the relevant coupling region. Therefore, we predict the transition to be continuous. We also compute critical exponents. The specific-heat exponent $\alpha$ is estimated as $\alpha = 0.20(15)$, while the magnetic susceptibility and magnetization exponents $\gamma_H$ and $\beta_H$ for Helium 3 are $\gamma_H = -0.34(5)$, $\beta_H = 1.07(9)$.

We compute the crossover exponent associated with the spin-3 operator in three-dimensional O(N) models. A six-loop field-theoretical calculation in the fixed-dimension approach gives $\phi_3 = 0.601(10)$ for the experimentally relevant case N=2 (XY model). The corresponding exponent $\beta_3 = 1.413(10)$ is compared with the experimental estimates obtained in materials undergoing a normal-incommensurate structural transition and in liquid crystals at the smectic-A--hexatic-B phase transition, finding good agreement.

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