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1. Hyperkalaemia in Cardiological Patients: New Solutions for an Old Problem

Author

Abrignani, M, Gronda, E, Marini, M, Gori, M, Iacoviello, M, Temporelli, P, Benvenuto, M, Binaghi, G, Cesaro, A, Maloberti, A, Tinti, M, Riccio, C, Colivicchi, F, Grimaldi, M, Gabrielli, D, Oliva, F, Abrignani M. G., Gronda E., Marini M., Gori M., Iacoviello M., Temporelli P. L., Benvenuto M., Binaghi G., Cesaro A., Maloberti A., Tinti M. D., Riccio C., Colivicchi F., Grimaldi M., Gabrielli D., Oliva F., Abrignani, M, Gronda, E, Marini, M, Gori, M, Iacoviello, M, Temporelli, P, Benvenuto, M, Binaghi, G, Cesaro, A, Maloberti, A, Tinti, M, Riccio, C, Colivicchi, F, Grimaldi, M, Gabrielli, D, Oliva, F, Abrignani M. G., Gronda E., Marini M., Gori M., Iacoviello M., Temporelli P. L., Benvenuto M., Binaghi G., Cesaro A., Maloberti A., Tinti M. D., Riccio C., Colivicchi F., Grimaldi M., Gabrielli D., and Oliva F.

Abstract

Hyperkalaemia is one of the most common electrolyte disorders in patients with cardiovascular disease (CVD). The true burden of hyperkalaemia in the real-world setting can be difficult to assess, but in population-based cohort studies up to 4 in 10 patients developed hyperkalaemia. In addition to drugs interfering with potassium metabolism and food intake, several conditions can cause or worsen hyperkalaemia, such as advanced age, diabetes, and chronic kidney disease. Mortality, cardiovascular morbidity, and hospitalisation are higher in patients with hyperkalaemia. Hyperkalaemia represents a major contraindication or a withholding cause for disease-modifying therapies like renin–angiotensin–aldosterone inhibitors (RAASi), mainly mineralocorticoid receptor antagonists. Hyperkalaemia can be also classified as acute and chronic, according to the onset. Acute hyperkalaemia is often a life-threatening emergency requiring immediate treatment to avoid lethal arrhythmias. Therapy goal is cell membrane stabilisation by calcium administration, cellular intake, shift of extracellular potassium to the intracellular space (insulin, beta-adrenergic agents, sodium bicarbonate), and increased elimination with diuretics or dialysis. Chronic hyperkalaemia was often managed with dietary counselling to prevent potassium-rich food intake and tapering of potassium-increasing drugs, mostly RAASi. Sodium polystyrene sulphonate, a potassium binder, was the only therapeutic option. Recently, new drugs such as patiromer and sodium zirconium cyclosilicate give new opportunities for the treatment of hyperkalaemia, as they proved to be safe, well tolerated, and effective. Aim of this review is to describe the burden of hyperkalaemia in cardiovascular patients, its direct and indirect effects, and the therapeutic options now available in the acute and chronic setting.

Published
2024

2. Non-linear excitation microscopy of live cells by using an implantable microscope objective-on-a-chip

Author

Tarnok, A, Houston, JP, Nardini, A, Vázquez, R, Conci, C, Grassi, M, Marini, M, Bouzin, M, Collini, M, Osellame, R, Cerullo, G, Kariman, B, Raimondi, M, Chirico, G, Nardini A., Vázquez R. M., Conci C., Grassi M., Marini M., Bouzin M., Collini M., Osellame R., Cerullo G. N., Kariman B. S., Raimondi M. T., Chirico G., Tarnok, A, Houston, JP, Nardini, A, Vázquez, R, Conci, C, Grassi, M, Marini, M, Bouzin, M, Collini, M, Osellame, R, Cerullo, G, Kariman, B, Raimondi, M, Chirico, G, Nardini A., Vázquez R. M., Conci C., Grassi M., Marini M., Bouzin M., Collini M., Osellame R., Cerullo G. N., Kariman B. S., Raimondi M. T., and Chirico G.

Abstract

In the context of biomaterials, small-molecules and drugs testing, intravital microscopy allows to quantify in-vivo the immune reaction, reducing the number of laboratory animals required to statistically validate the product. However, fluorescence microscopy is affected by limited tissue penetration due to light scattering and by optical aberrations, induced on focused beams, by the animal tissue surrounding the implant. In this framework, we developed a system of microlenses coupled to microscaffolds, both incorporated in a miniaturized imaging window. The chip is designed to act as an in-situ microscope objective with the aim to overcome the restrictions of in-vivo imaging (i.e. spherical aberrations) and to allow multiple biological observations in the same animal (by including fluorescent beacons). The device is fabricated by two-photon polymerizing a biocompatible photoresist called SZ2080. The microlenses are manufactured by the concentric polar scanning of the laser beam to realize their outer surface, followed by the UV bulk polymerization of their inner SZ2080. We preliminarily characterized the imaging capabilities of our implantable system on live cells cultured on flat substrates and 3D microscaffolds by coupling it to low magnification objectives. The microlenses optical quality is sufficient to induce non-linear excitation and collect two-photon excitation images with the same level of laser intensity and signal-to-noise ratio. Remarkably, they allow to efficiently excite the fluorescence of labelled human fibroblasts collecting high resolution magnified images. These results will open the way to the application of implanted micro-optics for the real-time and continuous in-vivo observation of complex biological processes.

Published
2024

3. Laser microfabrication for optical sensing and imaging in vivo

Author

Bianchini, P, Diaspro, A, Sheppard, CJR, Bouzin, M, Sironi, L, Marini, M, D'Alfonso, L, Collini, M, Chirico, G, Conci, C, Jacchetti, E, Raimondi, M, Nardini, A, Cerullo, G, Martinez Vazquez, R, Osellame, R, Sironi L., Marini M., Bouzin M., D'Alfonso L., Collini M., Chirico G., Conci C., Jacchetti E., Raimondi M. T., Nardini A., Cerullo G., Martinez Vazquez R., Osellame R., Bianchini, P, Diaspro, A, Sheppard, CJR, Bouzin, M, Sironi, L, Marini, M, D'Alfonso, L, Collini, M, Chirico, G, Conci, C, Jacchetti, E, Raimondi, M, Nardini, A, Cerullo, G, Martinez Vazquez, R, Osellame, R, Sironi L., Marini M., Bouzin M., D'Alfonso L., Collini M., Chirico G., Conci C., Jacchetti E., Raimondi M. T., Nardini A., Cerullo G., Martinez Vazquez R., and Osellame R.

Abstract

The possibility to fabricate microstructures to be used in the medical field is a reality. Further steps in this direction consist in the fabrication of active microstructures for implants and/or for cellular treatments. Two major areas of interest will be briefly treated here. The first is the one of stimulus-responsive optical polymers, especially hydrogels, that can be shaped by means of laser 3D printing and ablation. These can be used for thermal stimulation, energy transduction and sensing. The composition of these polymeric blends is an essential parameter to tune their properties as actuators and/or sensing platforms and to determine the elasto-mechanical characteristics of the printed hydrogel. A second field of interest is the microfabrication of rigid microstructures that can stand the tissue-induced stresses in implants. The increasing demand of microdevices for nanomedicine and personalized medicine has fostered the quest for an efficient combination of composite and hybrid photo-responsive materials and digital micro/nano-manufacturing. Existing works have exploited multiphoton laser photo-polymerization to obtain fine 3D microstructures in hydrogels in an additive manufacturing approach or exploited laser ablation of preformed hydrogels to carve 3D cavities. The aim of this report is to provide a short overview of the basics of photo-polymerization induced by two-photon excitation and to discuss two case studies. In the first one, we discuss the most recent and prominent results in the field of multiphoton laser direct writing of biocompatible hydrogels that embed active nanomaterials not interfering with the writing process and endowing the biocompatible microstructures with physically or chemically activable features such as photo-thermal activity, chemical swelling and chemical sensing. In the second case, we outline the fabrication steps and the first tests of a novel chip which aims at enabling longitudinal studies of the reaction to the biomater

Published
2023

4. Two-Photon Polymerization of an In-Vivo Multiphoton Imaging Window

Author

Vazquez, R, Nardini, A, Marini, M, Conci, C, Kariman, B, Bouzin, M, Collini, M, Chirico, G, Raimondi, M, Osellame, R, Cerullo, G, Vazquez R. M., Nardini A., Marini M., Conci C., Kariman B. S., Bouzin M., Collini M., Chirico G., Raimondi M. T., Osellame R., Cerullo G., Vazquez, R, Nardini, A, Marini, M, Conci, C, Kariman, B, Bouzin, M, Collini, M, Chirico, G, Raimondi, M, Osellame, R, Cerullo, G, Vazquez R. M., Nardini A., Marini M., Conci C., Kariman B. S., Bouzin M., Collini M., Chirico G., Raimondi M. T., Osellame R., and Cerullo G.

Abstract

Intravital microscopy windows for in vivo observation of tissue are desirable in many biomedical fields, from immunology to the assessment of the foreign body reaction to biomaterials. Moreover, they allow one to reduce the number of animals required to statistically validate biomaterials if compared with traditional histopathological analyses of animal biopsies [1,2].

Published
2023

5. Micro-Fabricated Optics for Multiphoton Microscopy

Author

Jaworski, M, Marciniak, M, Vazquez, R, Nardini, A, Conci, C, Jacchetti, E, Marini, M, Panzeri, D, Sironi, L, Bouzin, M, Collini, M, Inverso, D, Kariman, B, Kabouraki, E, Farsari, M, Osellame, R, Cerullo, G, Raimondi, M, Chirico, G, Vazquez R. M., Nardini A., Conci C., Jacchetti E., Marini M., Panzeri D., Sironi L., Bouzin M., Collini M., Inverso D., Kariman B. S., Kabouraki E., Farsari M., Osellame R., Cerullo G., Raimondi M. T., Chirico G., Jaworski, M, Marciniak, M, Vazquez, R, Nardini, A, Conci, C, Jacchetti, E, Marini, M, Panzeri, D, Sironi, L, Bouzin, M, Collini, M, Inverso, D, Kariman, B, Kabouraki, E, Farsari, M, Osellame, R, Cerullo, G, Raimondi, M, Chirico, G, Vazquez R. M., Nardini A., Conci C., Jacchetti E., Marini M., Panzeri D., Sironi L., Bouzin M., Collini M., Inverso D., Kariman B. S., Kabouraki E., Farsari M., Osellame R., Cerullo G., Raimondi M. T., and Chirico G.

Abstract

We report new methods of 2 photon polymerization of microlenses with high numerical aperture, large diameter and good optical quality. We characterize the aberrations of these lenses that, coupled to raster scanning optical microscopes, allow two-photon excitation imaging of cells. In-vivo non-linear imaging will be also discussed, opening the possibility to use these micro-lenses in implants for the continuous inspection of biological dynamics in vivo.

Published
2023

6. Microlenses Fabricated by Two‐Photon Laser Polymerization for Cell Imaging with Non‐Linear Excitation Microscopy

Author

Marini, M, Nardini, A, Martínez Vázquez, R, Conci, C, Bouzin, M, Collini, M, Osellame, R, Cerullo, G, Kariman, B, Farsari, M, Kabouraki, E, Raimondi, M, Chirico, G, Marini, M., Nardini, A., Martínez Vázquez, R., Conci, C., Bouzin, M., Collini, M., Osellame, R., Cerullo, G., Kariman, B. S., Farsari, M., Kabouraki, E., Raimondi, M. T., Chirico, G., Marini, M, Nardini, A, Martínez Vázquez, R, Conci, C, Bouzin, M, Collini, M, Osellame, R, Cerullo, G, Kariman, B, Farsari, M, Kabouraki, E, Raimondi, M, Chirico, G, Marini, M., Nardini, A., Martínez Vázquez, R., Conci, C., Bouzin, M., Collini, M., Osellame, R., Cerullo, G., Kariman, B. S., Farsari, M., Kabouraki, E., Raimondi, M. T., and Chirico, G.

Abstract

Non-linear excitation microscopy offers several advantages for in-vivo imaging compared to conventional confocal techniques. However, tissue penetration can still be an issue due to scattering and spherical aberrations induced on focused beams by the tissue. The use of low numerical aperture objectives to pass through the outer layers of the skin, together with high dioptric power microlenses implanted in-vivo close to the observation volume, can be beneficial to the reduction of optical aberrations. Here, Fibroblast cell culture plano-convex microlenses to be used for non-linear imaging of biological tissue are developed and tested. The microlenses can be used as single lenses or multiplexed in an array. A thorough test of the lenses wavefront is reported together with the modulation transfer function and wavefront profile. Magnified fluorescence images can be retrieved through the microlenses coupled to commercial confocal and two-photon excitation scanning microscopes. The signal-to-noise ratio of the images is not substantially affected by the use of the microlenses and the magnification can be adjusted by changing the relative position of the microlens array to the microscope objective and the immersion medium. These results are opening the way to the application of implanted micro-optics for optical in-vivo inspection of biological processes.

Published
2023

7. Two-photon laser polymerized microlenses for non-linear excitation microscopy of biological samples

Author

Ferraro, P, Psaltis, D, Grilli, S, Nardini, A, Vazquez, R, Marini, M, Conci, C, Bouzin, M, Collini, M, Osellame, R, Cerullo, G, Kariman, B, Farsari, M, Kabouraki, E, Chirico, G, Raimondi, M, Nardini A., Vazquez R. M., Marini M., Conci C., Bouzin M., Collini M., Osellame R., Cerullo G., Kariman B. S., Farsari M., Kabouraki E., Chirico G., Raimondi M. T., Ferraro, P, Psaltis, D, Grilli, S, Nardini, A, Vazquez, R, Marini, M, Conci, C, Bouzin, M, Collini, M, Osellame, R, Cerullo, G, Kariman, B, Farsari, M, Kabouraki, E, Chirico, G, Raimondi, M, Nardini A., Vazquez R. M., Marini M., Conci C., Bouzin M., Collini M., Osellame R., Cerullo G., Kariman B. S., Farsari M., Kabouraki E., Chirico G., and Raimondi M. T.

Abstract

We report new methods of 2 photon polymerization of microlenses with high numerical aperture, large diameter and good optical quality. We characterize the aberrations of these lenses that, coupled to raster scanning optical microscopes, allow two-photon excitation imaging of cells. In-vivo non-linear imaging will be also discussed, opening the possibility to use these micro-lenses in implants for the continuous inspection of biological dynamics in vivo.

Published
2023

8. Melanin concentration maps by label-free super-resolution photo-thermal imaging on melanoma biopsies

Author

Bouzin, M, Marini, M, Chirico, G, Granucci, F, Mingozzi, F, Colombo, R, D'Alfonso, L, Sironi, L, Collini, M, Bouzin M., Marini M., Chirico G., Granucci F., Mingozzi F., Colombo R., D'Alfonso L., Sironi L., Collini M., Bouzin, M, Marini, M, Chirico, G, Granucci, F, Mingozzi, F, Colombo, R, D'Alfonso, L, Sironi, L, Collini, M, Bouzin M., Marini M., Chirico G., Granucci F., Mingozzi F., Colombo R., D'Alfonso L., Sironi L., and Collini M.

Abstract

Surgical excision followed by histopathological examination is the gold standard for melanoma screening. However, the color-based inspection of hematoxylin-and-eosin-stained biopsies does not provide a space-resolved quantification of the melanin content in melanocytic lesions. We propose a non-destructive photo-thermal imaging method capable of characterizing the microscopic distribution and absolute concentration of melanin pigments in excised melanoma biopsies. By exploiting the photo-thermal effect primed by melanin absorption of visible laser light we obtain label-free super-resolution far-infrared thermal images of tissue sections where melanin is spatially mapped at sub-diffraction 40-µm resolution. Based on the finite-element simulation of the full 3D heat transfer model, we are able to convert temperature maps into quantitative images of the melanin molar concentration on B16 murine melanoma biopsies, with 4·10−4 M concentration sensitivity. Being readily applicable to human melanoma biopsies in combination with hematoxylin-and-eosin staining, the proposed approach could complement traditional histopathology in the characterization of pigmented lesions ex-vivo.

Published
2022

9. A miniaturized chip for 3D optical imaging of tissue regeneration in vivo

Author

Popp, J, Gergely, C, Conci, C, Jacchetti, E, Sironi, L, Gentili, L, Cerullo, G, Martinez, R, Osellame, R, Marini, M, Bouzin, M, Collini, M, D'Alfonso, L, Kabouraki, E, Farsari, M, Ranella, A, Kehagias, N, Chirico, G, Raimondi, M, Conci C., Jacchetti E., Sironi L., Gentili L., Cerullo G., Martinez R., Osellame R., Marini M., Bouzin M., Collini M., D'Alfonso L., Kabouraki E., Farsari M., Ranella A., Kehagias N., Chirico G., Raimondi M. T., Popp, J, Gergely, C, Conci, C, Jacchetti, E, Sironi, L, Gentili, L, Cerullo, G, Martinez, R, Osellame, R, Marini, M, Bouzin, M, Collini, M, D'Alfonso, L, Kabouraki, E, Farsari, M, Ranella, A, Kehagias, N, Chirico, G, Raimondi, M, Conci C., Jacchetti E., Sironi L., Gentili L., Cerullo G., Martinez R., Osellame R., Marini M., Bouzin M., Collini M., D'Alfonso L., Kabouraki E., Farsari M., Ranella A., Kehagias N., Chirico G., and Raimondi M. T.

Abstract

The current protocols for biocompatibility assessment of biomaterials, based on histopathology, require the sacrifice of a huge number of laboratory animals with an unsustainable ethical burden and remarkable cost. Intravital microscopy techniques can be used to study implantation outcomes in real time though with limited capabilities of quantification in longitudinal studies, mainly restricted by the light penetration and the spatial resolution in deep tissues. We present the outline and first tests of a novel chip which aims to enable longitudinal studies of the reaction to the biomaterial implant. The chip is composed of a regular reference microstructure fabricated via two-photon polymerization in the SZ2080 resist. The geometrical design and the planar raster spacing largely determine the mechanical and spectroscopic features of the microstructures. The development, in-vitro characterization and in vivo validation of the Microatlas is performed in living chicken embryos by fluorescence microscopy 3 and 4 days after the implant; the quantification of cell infiltration inside the Microatlas demonstrates its potential as novel scaffold for tissue regeneration.

Published
2022

10. Prevalence, Characteristics, and Outcomes of COVID-19-Associated Acute Myocarditis

Author

Ammirati, E, Lupi, L, Palazzini, M, Hendren, N, Grodin, J, Cannistraci, C, Schmidt, M, Hekimian, G, Peretto, G, Bochaton, T, Hayek, A, Piriou, N, Leonardi, S, Guida, S, Turco, A, Sala, S, Uribarri, A, Van De Heyning, C, Mapelli, M, Campodonico, J, Pedrotti, P, Barrionuevo Sanchez, M, Ariza Sole, A, Marini, M, Matassini, M, Vourc'H, M, Cannata, A, Bromage, D, Briguglia, D, Salamanca, J, Diez-Villanueva, P, Lehtonen, J, Huang, F, Russel, S, Soriano, F, Turrini, F, Cipriani, M, Bramerio, M, Di Pasquale, M, Grosu, A, Senni, M, Farina, D, Agostoni, P, Rizzo, S, De Gaspari, M, Marzo, F, Duran, J, Adler, E, Giannattasio, C, Basso, C, Mcdonagh, T, Kerneis, M, Combes, A, Camici, P, De Lemos, J, Metra, M, Ammirati E., Lupi L., Palazzini M., Hendren N. S., Grodin J. L., Cannistraci C. V., Schmidt M., Hekimian G., Peretto G., Bochaton T., Hayek A., Piriou N., Leonardi S., Guida S., Turco A., Sala S., Uribarri A., Van De Heyning C. M., Mapelli M., Campodonico J., Pedrotti P., Barrionuevo Sanchez M. I., Ariza Sole A., Marini M., Matassini M. V., Vourc'H M., Cannata A., Bromage D. I., Briguglia D., Salamanca J., Diez-Villanueva P., Lehtonen J., Huang F., Russel S., Soriano F., Turrini F., Cipriani M., Bramerio M., Di Pasquale M., Grosu A., Senni M., Farina D., Agostoni P., Rizzo S., De Gaspari M., Marzo F., Duran J. M., Adler E. D., Giannattasio C., Basso C., McDonagh T., Kerneis M., Combes A., Camici P. G., De Lemos J. A., Metra M., Ammirati, E, Lupi, L, Palazzini, M, Hendren, N, Grodin, J, Cannistraci, C, Schmidt, M, Hekimian, G, Peretto, G, Bochaton, T, Hayek, A, Piriou, N, Leonardi, S, Guida, S, Turco, A, Sala, S, Uribarri, A, Van De Heyning, C, Mapelli, M, Campodonico, J, Pedrotti, P, Barrionuevo Sanchez, M, Ariza Sole, A, Marini, M, Matassini, M, Vourc'H, M, Cannata, A, Bromage, D, Briguglia, D, Salamanca, J, Diez-Villanueva, P, Lehtonen, J, Huang, F, Russel, S, Soriano, F, Turrini, F, Cipriani, M, Bramerio, M, Di Pasquale, M, Grosu, A, Senni, M, Farina, D, Agostoni, P, Rizzo, S, De Gaspari, M, Marzo, F, Duran, J, Adler, E, Giannattasio, C, Basso, C, Mcdonagh, T, Kerneis, M, Combes, A, Camici, P, De Lemos, J, Metra, M, Ammirati E., Lupi L., Palazzini M., Hendren N. S., Grodin J. L., Cannistraci C. V., Schmidt M., Hekimian G., Peretto G., Bochaton T., Hayek A., Piriou N., Leonardi S., Guida S., Turco A., Sala S., Uribarri A., Van De Heyning C. M., Mapelli M., Campodonico J., Pedrotti P., Barrionuevo Sanchez M. I., Ariza Sole A., Marini M., Matassini M. V., Vourc'H M., Cannata A., Bromage D. I., Briguglia D., Salamanca J., Diez-Villanueva P., Lehtonen J., Huang F., Russel S., Soriano F., Turrini F., Cipriani M., Bramerio M., Di Pasquale M., Grosu A., Senni M., Farina D., Agostoni P., Rizzo S., De Gaspari M., Marzo F., Duran J. M., Adler E. D., Giannattasio C., Basso C., McDonagh T., Kerneis M., Combes A., Camici P. G., De Lemos J. A., and Metra M.

Abstract

Background: Acute myocarditis (AM) is thought to be a rare cardiovascular complication of COVID-19, although minimal data are available beyond case reports. We aim to report the prevalence, baseline characteristics, in-hospital management, and outcomes for patients with COVID-19-associated AM on the basis of a retrospective cohort from 23 hospitals in the United States and Europe. Methods: A total of 112 patients with suspected AM from 56 963 hospitalized patients with COVID-19 were evaluated between February 1, 2020, and April 30, 2021. Inclusion criteria were hospitalization for COVID-19 and a diagnosis of AM on the basis of endomyocardial biopsy or increased troponin level plus typical signs of AM on cardiac magnetic resonance imaging. We identified 97 patients with possible AM, and among them, 54 patients with definite/probable AM supported by endomyocardial biopsy in 17 (31.5%) patients or magnetic resonance imaging in 50 (92.6%). We analyzed patient characteristics, treatments, and outcomes among all COVID-19-associated AM. Results: AM prevalence among hospitalized patients with COVID-19 was 2.4 per 1000 hospitalizations considering definite/probable and 4.1 per 1000 considering also possible AM. The median age of definite/probable cases was 38 years, and 38.9% were female. On admission, chest pain and dyspnea were the most frequent symptoms (55.5% and 53.7%, respectively). Thirty-one cases (57.4%) occurred in the absence of COVID-19-associated pneumonia. Twenty-one (38.9%) had a fulminant presentation requiring inotropic support or temporary mechanical circulatory support. The composite of in-hospital mortality or temporary mechanical circulatory support occurred in 20.4%. At 120 days, estimated mortality was 6.6%, 15.1% in patients with associated pneumonia versus 0% in patients without pneumonia (P=0.044). During hospitalization, left ventricular ejection fraction, assessed by echocardiography, improved from a median of 40% on admission to 55% at discharge

Published
2022

11. Frames and Inferences

Author

Ansani, A., Marini, M., Paglieri, F., Fairclough, Isabela, Ansani, A., Marini, M., Paglieri, F., and Fairclough, Isabela

Abstract

I argue that framing works via an inferential process, by ‘inviting’ a conclusion which an audience may accept or reject, from premises they may accept or reject (resulting in a successful or failed ‘framing effect’). I take framing to be, covertly, a directive speech act, with two main mechanisms: the audience is either being ‘invited’ to see a situation as X (not as Y) or is being ‘invited’ to take a reason Z as one that ought to outweigh all other reasons in deciding what to believe or do. I will draw on the Argumentum Model of Topics to represent a few arguments where framing occurs either in the minor or major premise, which may be either accepted or rejected; in the latter case, the ‘invited inference’ is replaced by an alternative counter-inference. The AMT seems very well placed to account both for how a framing source intends an argument to be reconstructed and accepted by an audience, and for how the audience may reject the invited inference and draw another conclusion.

Published
2023

12. Frames and Inferences

Author

Ansani, A., Marini, M., Paglieri, F., Fairclough, Isabela, Ansani, A., Marini, M., Paglieri, F., and Fairclough, Isabela

Abstract

I argue that framing works via an inferential process, by ‘inviting’ a conclusion which an audience may accept or reject, from premises they may accept or reject (resulting in a successful or failed ‘framing effect’). I take framing to be, covertly, a directive speech act, with two main mechanisms: the audience is either being ‘invited’ to see a situation as X (not as Y) or is being ‘invited’ to take a reason Z as one that ought to outweigh all other reasons in deciding what to believe or do. I will draw on the Argumentum Model of Topics to represent a few arguments where framing occurs either in the minor or major premise, which may be either accepted or rejected; in the latter case, the ‘invited inference’ is replaced by an alternative counter-inference. The AMT seems very well placed to account both for how a framing source intends an argument to be reconstructed and accepted by an audience, and for how the audience may reject the invited inference and draw another conclusion.

Published
2023

13. Multiphoton laser fabrication of hybrid photo-activable biomaterials

Author

Bouzin, M, Zeynali, A, Marini, M, Sironi, L, Scodellaro, R, D'Alfonso, L, Collini, M, Chirico, G, Bouzin M., Zeynali A., Marini M., Sironi L., Scodellaro R., D'alfonso L., Collini M., Chirico G., Bouzin, M, Zeynali, A, Marini, M, Sironi, L, Scodellaro, R, D'Alfonso, L, Collini, M, Chirico, G, Bouzin M., Zeynali A., Marini M., Sironi L., Scodellaro R., D'alfonso L., Collini M., and Chirico G.

Abstract

The possibility to shape stimulus-responsive optical polymers, especially hydrogels, by means of laser 3D printing and ablation is fostering a new concept of “smart” micro-devices that can be used for imaging, thermal stimulation, energy transducing and sensing. The composition of these polymeric blends is an essential parameter to tune their properties as actuators and/or sensing platforms and to determine the elasto-mechanical characteristics of the printed hydrogel. In light of the increasing demand for micro-devices for nanomedicine and personalized medicine, interest is growing in the combination of composite and hybrid photo-responsive materials and digital micro-/nano-manufacturing. Existing works have exploited multiphoton laser photo-polymerization to obtain fine 3D microstructures in hydrogels in an additive manufacturing approach or exploited laser ablation of preformed hydrogels to carve 3D cavities. Less often, the two approaches have been combined and active nanomaterials have been embedded in the microstructures. The aim of this review is to give a short overview of the most recent and prominent results in the field of multiphoton laser direct writing of biocompatible hydrogels that embed active nanomaterials not interfering with the writing process and endowing the biocompatible microstructures with physically or chemically activable features such as photothermal activity, chemical swelling and chemical sensing.

Published
2021

14. Multiphoton laser fabrication of hybrid photo-activable biomaterials

Author

Bouzin, M, Zeynali, A, Marini, M, Sironi, L, Scodellaro, R, D'Alfonso, L, Collini, M, Chirico, G, Bouzin M., Zeynali A., Marini M., Sironi L., Scodellaro R., D'alfonso L., Collini M., Chirico G., Bouzin, M, Zeynali, A, Marini, M, Sironi, L, Scodellaro, R, D'Alfonso, L, Collini, M, Chirico, G, Bouzin M., Zeynali A., Marini M., Sironi L., Scodellaro R., D'alfonso L., Collini M., and Chirico G.

Abstract

The possibility to shape stimulus-responsive optical polymers, especially hydrogels, by means of laser 3D printing and ablation is fostering a new concept of “smart” micro-devices that can be used for imaging, thermal stimulation, energy transducing and sensing. The composition of these polymeric blends is an essential parameter to tune their properties as actuators and/or sensing platforms and to determine the elasto-mechanical characteristics of the printed hydrogel. In light of the increasing demand for micro-devices for nanomedicine and personalized medicine, interest is growing in the combination of composite and hybrid photo-responsive materials and digital micro-/nano-manufacturing. Existing works have exploited multiphoton laser photo-polymerization to obtain fine 3D microstructures in hydrogels in an additive manufacturing approach or exploited laser ablation of preformed hydrogels to carve 3D cavities. Less often, the two approaches have been combined and active nanomaterials have been embedded in the microstructures. The aim of this review is to give a short overview of the most recent and prominent results in the field of multiphoton laser direct writing of biocompatible hydrogels that embed active nanomaterials not interfering with the writing process and endowing the biocompatible microstructures with physically or chemically activable features such as photothermal activity, chemical swelling and chemical sensing.

Published
2021

15. Multiphoton fabrication of flexible photo-thermally active proteinaceous microstructures

Author

Zeynali, A, Marini, M, Collini, M, Bouzin, M, Sironi, L, D'Alfonso, L, Pallavicini, P, Chirico, G, Zeynali A., Marini M., Collini M., Bouzin M., Sironi L., D'Alfonso L., Pallavicini P., Chirico G., Zeynali, A, Marini, M, Collini, M, Bouzin, M, Sironi, L, D'Alfonso, L, Pallavicini, P, Chirico, G, Zeynali A., Marini M., Collini M., Bouzin M., Sironi L., D'Alfonso L., Pallavicini P., and Chirico G.

Abstract

Two-photon and single photon laser writing are used here to fabricate 3D proteinaceous microstructures with photothermal functionality in the near-infrared spectral region and tunable elasticity. The photo-cross-linking is initiated in bovine serum albumin (BSA) by Rose Bengal and the photo-thermal effect arises from gold nanostars dispersed in the ink. Massive energy transfer of the plasmonic resonances of the gold nanostars to the photo-initiator is avoided by employing an anionic photo-initiator, allowing to obtain effective photo-crosslinking of BSA and to retrieve a substantial photo-thermal efficiency of the fabricated structures. On these microstructures, with a gold atom concentration as low as 1% w/w, a highly localized temperature increase can be quickly (≅1 s) reached and maintained under continuous wave laser irradiation at 800 nm. The photothermal efficiency under continuous wave laser irradiation depends on the thickness of the microstructure and can reach 12.2 +/- 0.4 °C/W. The Young modulus of the fabricated structures is estimated from the measurement of their bending under steady flow and falls in the range of most typical tissues, suggesting that they can be adopted as promising platform for future applications in regenerative nanomedicine.

Published
2021

16. Changes in surgicaL behaviOrs dUring the CoviD-19 pandemic. The SICE CLOUD19 Study

Author

Bracale, U, Podda, M, Castiglioni, S, Peltrini, R, Sartori, A, Arezzo, A, Corcione, F, Agresta, F, Antonucci, A, Zanframundo, C, Cavallo, F, Mazzarolo, G, Agrusa, A, Di Buono, G, Aldrighetti, L, Fiorentini, G, Lucianetti, A, Magnone, S, Alfieri, S, Rosa, F, Altomare, D, Picciariello, A, Parisi, A, Di Cintio, A, Amisano, M, Cravero, F, Ammendola, M, Ammerata, G, Anastasi, A, Canonico, G, Gattolin, A, Travaglio, E, De Palma, M, Angelini, P, Galante, F, Benevento, A, Rausei, S, Serao, A, Abbatini, F, Annecchiarico, M, Varricchio, A, Annessi, V, Tumiati, D, Annicchiarico, A, Mirabella, A, Marino, M, Spinelli, A, Braun, A, Santi, H, Romano, L, Antoniutti, M, Armellino, M, Argenio, G, Verzelli, A, Budassi, A, Baiocchi, G, Alfano, M, Balani, A, Barone, M, Baldazzi, G, Cassini, D, Canger, R, Zabbialini, G, Belli, A, Izzo, F, Bertolino, F, Brunetti, M, Bianco, F, Cappiello, A, Boccia, L, Boffi, B, Perna, F, Bonilauri, S, Frazzetta, G, Bordoni, P, Fleres, F, Borghi, F, Giraudo, G, Bottino, V, Canfora, A, Piccoli, F, Calligaris, L, Nipote, B, Nasti, A, Bufalari, A, Bettarini, F, Buononato, M, Greco, M, Calo, P, Medas, F, Cardamone, E, Castaldo, P, Carlini, M, Spoletini, D, De Nisco, C, Pulighe, F, Feo, C, Fabbri, N, Antropoli, C, Foroni, F, Carnazza, M, Ragazzi, S, Cassinotti, E, Boni, L, Catena, F, Giuffrida, M, Perrone, G, Ccotsoglou, C, Granieri, S, Ceccarelli, G, Bugiantella, W, Cedolini, C, Seriau, L, Cesari, M, Contine, A, Chiara, O, Cimbanassi, S, Cocozza, E, Berselli, M, Fantini, C, Costi, R, Casali, L, Morini, A, Crafa, F, Vanela, S, Curro, G, Orsini, V, Da Lio, C, Biral, M, Danelli, P, Guerci, C, Scala, D, Marino, G, De Carlis, L, Lauterio, A, De Giorgi, D, Sciannamea, G, De Manzini, N, Losurdo, P, Sangiuliano, N, Degiuli, M, Caterina, F, Del Rio, P, Bonati, E, Di Lernia, S, Ardizzone, M, Di Saverio, S, Franchi, C, Di Venere, B, Miglio, R, Cuccurullo, D, Sagnelli, C, Docimo, L, Tolone, S, Longoni, M, Faillace, G, Rondelli, F, Pennella, F, Colucci, V, Carfora, T, Muttillo, I, Picardi, B, Stefano, R, Campagnacci, R, Maurizi, A, Tricarico, F, Montagna, M, Amedeo, E, Scollica, M, Lauro, E, Laterza, E, Molinari, E, Berta, G, Bono, D, Fabozzi, M, Romano, M, Facci, E, Parini, D, Farfaglia, R, Arizzi, V, Farsi, M, Miranda, E, Fei, L, Flavio, G, Pirozzi, F, Sciuto, A, Ferrero, A, Palisi, M, Filauro, M, Barberis, A, Azzinnaro, A, Fiscon, V, Vigna, S, D'Ambra, M, Pontecorvi, E, Anania, G, Bombardini, C, Galizia, G, Auricchio, A, Cardella, F, Genna, M, Gentilli, S, Herald, N, Castagnoli, G, Bartoli, A, Gianotti, L, Garancini, M, Bellanova, G, Palazzo, P, De Palma, G, Milone, M, Ferrari, G, Magistro, C, Giuliani, A, Di Natale, G, Brisinda, G, Cavallaro, G, Sammarco, G, Gallo, G, Goletti, O, Macchini, D, Greco, V, Amoroso, V, Guercioni, G, Benedetti, M, Guzzo, G, Pata, F, Scandroglio, I, Roscio, F, Jovine, E, Lombardi, R, La Rocca, F, Di Capua, F, Lanci, C, Leli, R, Borasi, A, Lepiane, P, Balla, A, Liberatore, E, Morelli, L, Di Franco, G, Lucchi, A, Vittori, L, Bonavina, L, Asti, E, Maggioni, D, Martino, G, Manca, G, Delvecchio, A, Tedesco, M, Gambardella, D, Marafioti, S, De Marco, M, Guicciardi, M, Motta, M, Calgaro, M, Adamo, V, Guerrieri, M, Coletta, P, Ortenzi, M, Martines, G, Lantone, G, Martinotti, M, Fassardi, G, Castriconi, M, Squillante, S, De Luca, M, Pavanello, M, Di Marco, C, Ronconi, M, Casiraghi, S, Mazzaferro, V, Battiston, C, Perrotta, M, Ripa, C, Giancarlo, M, Panizzo, V, Millo, P, Contul, R, Ferraro, V, Molino, C, Crolla, E, Moretto, G, Bacchion, M, Morino, M, Allaix, M, Motterlini, E, Petracca, M, Muratore, A, Musella, M, Vitiello, A, Nardo, B, Crocco, V, Navarra, G, Lazzara, S, Cuoghi, M, Olmi, S, Oldani, A, Uccelli, M, Opocher, E, Giovenzana, M, De Paolis, P, Santarelli, M, Delrio, P, Carbone, F, Bianchi, P, Formisano, Capelli, P, Baldini, E, Festa, P, Mottola, A, Merola, G, Perrotta, N, Celiento, M, Personnettaz, E, Muzio, S, Petitti, T, Melchiorre, A, Piccoli, M, Pecchini, F, Frontali, A, Maffioli, A, Maida, P, Tammaro, P, Pignata, G, Andreuccetti, J, Pilone, V, Renzulli, M, Pintaldi, S, Ceretti, A, Mariani, N, Pisanu, A, Polastri, R, Maiello, F, Porcu, A, Perra, T, Mucilli, F, Troisi, R, Montalti, R, Scognamillo, F, Delogu, D, Galleano, R, Malerba, M, Salfi, R, Pisano, M, Sechi, R, Cillara, N, Ramuscello, S, De Leo, E, Restini, E, Tumolo, R, Cianci, P, Capuzzolo, S, Rizzo, M, Recordare, A, Santoro, R, Amodio, P, Rocca, A, Cecere, G, Romito, R, Portigliotti, L, Rosati, R, Elmore, U, Russello, D, Latteri, S, Costarella, S, Massa, S, Capasso, L, Santangelo, M, Sodo, M, Sarro, G, Rivolta, U, Scabini, S, Pertile, D, Selvaggi, F, Rossi, S, Pellino, G, Sganga, G, Fransvea, P, Testa, S, De Rosa, C, Siquini, W, Trana, C, Solej, M, Bolzon, S, Guerra, E, Stella, M, Ferrara, F, Stipa, F, Stringhi, E, Celotti, A, Taglietti, L, Del Giudice, R, Talarico, C, Ruggiero, M, Tirone, G, Romario, U, Petz, W, Caracino, V, Rossetti, V, Verza, L, Vescovi, L, Marini, M, Vettoretto, N, Botteri, E, Vincenti, L, Giannandrea, G, Viora, T, Maganuco, L, Veronesi, P, Zani, B, Zanus, G, Brizzolari, M, Zanzi, F, Guariniello, A, Zappa, M, Galfrascoli, E, Zonta, S, Oragano, L, Zuliani, W, Chiari, D, Bracale U., Podda M., Castiglioni S., Peltrini R., Sartori A., Arezzo A., Corcione F., Agresta F., Antonucci A., Zanframundo C., Cavallo F., Mazzarolo G., Agrusa A., Di Buono G., Aldrighetti L., Fiorentini G., Lucianetti A., Magnone S., Alfieri S., Rosa F., Altomare D. F., Picciariello A., Parisi A., Di Cintio A., Amisano M. F., Cravero F., Ammendola M., Ammerata G., Anastasi A., Canonico G., Gattolin A., Travaglio E., De Palma M., Angelini P., Galante F., Benevento A., Rausei S., Serao A., Abbatini F., Annecchiarico M., Varricchio A., Annessi V., Tumiati D., Annicchiarico A., Mirabella A., Marino M. V., Spinelli A., Braun A., Santi H. T., Romano L., Antoniutti M., Armellino M. F., Argenio G., Verzelli A., Budassi A., Baiocchi G., Alfano M. S., Balani A., Barone M., Baldazzi G., Cassini D., Canger R. C. B., Zabbialini G., Belli A., Izzo F., Bertolino F., Brunetti M., Bianco F., Cappiello A., Boccia L., Boffi B., Perna F., Bonilauri S., Frazzetta G., Bordoni P., Fleres F., Borghi F., Giraudo G., Bottino V., Canfora A., Piccoli F. B., Calligaris L., Nipote B., Nasti A. G., Bufalari A., Bettarini F., Buononato M., Greco M., Calo P. G., Medas F., Cardamone E., Castaldo P., Carlini M., Spoletini D., De Nisco C., Pulighe F., Feo C. V., Fabbri N., Antropoli C., Foroni F., Carnazza M., Ragazzi S., Cassinotti E., Boni L., Catena F., Giuffrida M., Perrone G., Ccotsoglou C., Granieri S., Ceccarelli G., Bugiantella W., Cedolini C., Seriau L., Cesari M., Contine A., Chiara O., Cimbanassi S., Cocozza E., Berselli M., Fantini C., Costi R., Casali L., Morini A., Crafa F., Vanela S., Curro G., Orsini V., Da Lio C., Biral M., Danelli P., Guerci C., Scala D., Marino G., De Carlis L., Lauterio A., De Giorgi D., Sciannamea G., De Manzini N., Losurdo P., Sangiuliano N., Degiuli M., Caterina F., Del Rio P., Bonati E., Di Lernia S., Ardizzone M. V. R., Di Saverio S., Franchi C., Di Venere B., Miglio R., Cuccurullo D., Sagnelli C., Docimo L., Tolone S., Longoni M., Faillace G., Rondelli F., Pennella F. P., Colucci V., Carfora T., Muttillo I. A., Picardi B., Stefano R., Campagnacci R., Maurizi A., Tricarico F., Montagna M., Amedeo E., Scollica M. C., Lauro E., Laterza E., Molinari E., Berta G., Bono D., Fabozzi M., Romano M., Facci E., Parini D., Farfaglia R., Arizzi V., Farsi M., Miranda E., Fei L., Flavio G., Pirozzi F., Sciuto A., Ferrero A., Palisi M., Filauro M., Barberis A., Azzinnaro A., Fiscon V., Vigna S., D'ambra M., Pontecorvi E., Anania G., Bombardini C., Galizia G., Auricchio A., Cardella F., Genna M., Gentilli S., Herald N., Castagnoli G., Bartoli A., Gianotti L., Garancini M., Bellanova G., Palazzo P., De Palma G., Milone M., Ferrari G., Magistro C., Giuliani A., Di Natale G., Brisinda G., Cavallaro G., Sammarco G., Gallo G., Goletti O., Macchini D., Greco V., Amoroso V., Guercioni G., Benedetti M., Guzzo G., Pata F., Scandroglio I., Roscio F., Jovine E., Lombardi R., La Rocca F., Di Capua F., Lanci C., Leli R., Borasi A., Lepiane P., Balla A., Liberatore E., Morelli L., Di Franco G., Lucchi A., Vittori L., Bonavina L., Asti E., Maggioni D., Martino G., Manca G., Delvecchio A., Tedesco M., Gambardella D., Marafioti S., De Marco M. L., Guicciardi M. A., Motta M., Calgaro M., Adamo V., Guerrieri M., Coletta P., Ortenzi M., Martines G., Lantone G., Martinotti M., Fassardi G., Castriconi M., Squillante S., De Luca M., Pavanello M., Di Marco C., Ronconi M., Casiraghi S., Mazzaferro V., Battiston C., Perrotta M., Ripa C., Giancarlo M., Panizzo V., Millo P., Contul R. B., Ferraro V., Molino C., Crolla E., Moretto G., Bacchion M., Morino M., Allaix M. E., Motterlini E., Petracca M., Muratore A., Musella M., Vitiello A., Nardo B., Crocco V., Navarra G., Lazzara S., Navarra G. G., Cuoghi M., Olmi S., Oldani A., Uccelli M., Opocher E., Giovenzana M., De Paolis P., Santarelli M., Delrio P., Carbone F., Bianchi P. P. G., Capelli P., Baldini E., Festa P., Mottola A., Merola G., Perrotta N., Celiento M., Personnettaz E., Muzio S., Petitti T., Melchiorre A., Piccoli M., Pecchini F., Frontali A., Maffioli A., Maida P., Tammaro P., Pignata G., Andreuccetti J., Pilone V., Renzulli M., Pintaldi S., Ceretti A. P., Mariani N. M., Pisanu A., Polastri R., Maiello F., Porcu A., Perra T., Mucilli F., Troisi R., Montalti R., Scognamillo F., Delogu D., Galleano R., Malerba M., Salfi R., Pisano M., Sechi R., Cillara N., Ramuscello S., De Leo E., Restini E., Tumolo R., Cianci P., Capuzzolo S., Rizzo M., Recordare A., Santoro R., Amodio P. M., Rocca A., Cecere G., Romito R., Portigliotti L., Rosati R., Elmore U., Russello D., Latteri S., Costarella S. M., Massa S., Capasso L., Santangelo M., Sodo M., Sarro G., Rivolta U., Scabini S., Pertile D., Selvaggi F., Rossi S., Pellino G., Sganga G., Fransvea P., Testa S., De Rosa C., Siquini W., Trana C., Solej M., Bolzon S., Guerra E., Stella M., Ferrara F., Stipa F., Stringhi E., Celotti A., Taglietti L., Del Giudice R., Talarico C. A., Ruggiero M., Tirone G., Romario U. F., Petz W., Caracino V., Rossetti V., Verza L. 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A., Galfrascoli E., Zonta S., Oragano L., Zuliani W., Chiari D., Bracale, U, Podda, M, Castiglioni, S, Peltrini, R, Sartori, A, Arezzo, A, Corcione, F, Agresta, F, Antonucci, A, Zanframundo, C, Cavallo, F, Mazzarolo, G, Agrusa, A, Di Buono, G, Aldrighetti, L, Fiorentini, G, Lucianetti, A, Magnone, S, Alfieri, S, Rosa, F, Altomare, D, Picciariello, A, Parisi, A, Di Cintio, A, Amisano, M, Cravero, F, Ammendola, M, Ammerata, G, Anastasi, A, Canonico, G, Gattolin, A, Travaglio, E, De Palma, M, Angelini, P, Galante, F, Benevento, A, Rausei, S, Serao, A, Abbatini, F, Annecchiarico, M, Varricchio, A, Annessi, V, Tumiati, D, Annicchiarico, A, Mirabella, A, Marino, M, Spinelli, A, Braun, A, Santi, H, Romano, L, Antoniutti, M, Armellino, M, Argenio, G, Verzelli, A, Budassi, A, Baiocchi, G, Alfano, M, Balani, A, Barone, M, Baldazzi, G, Cassini, D, Canger, R, Zabbialini, G, Belli, A, Izzo, F, Bertolino, F, Brunetti, M, Bianco, F, Cappiello, A, Boccia, L, Boffi, B, Perna, F, Bonilauri, S, Frazzetta, G, Bordoni, P, Fleres, F, Borghi, F, Giraudo, G, Bottino, V, Canfora, A, Piccoli, F, Calligaris, L, Nipote, B, Nasti, A, Bufalari, A, Bettarini, F, Buononato, M, Greco, M, Calo, P, Medas, F, Cardamone, E, Castaldo, P, Carlini, M, Spoletini, D, De Nisco, C, Pulighe, F, Feo, C, Fabbri, N, Antropoli, C, Foroni, F, Carnazza, M, Ragazzi, S, Cassinotti, E, Boni, L, Catena, F, Giuffrida, M, Perrone, G, Ccotsoglou, C, Granieri, S, Ceccarelli, G, Bugiantella, W, Cedolini, C, Seriau, L, Cesari, M, Contine, A, Chiara, O, Cimbanassi, S, Cocozza, E, Berselli, M, Fantini, C, Costi, R, Casali, L, Morini, A, Crafa, F, Vanela, S, Curro, G, Orsini, V, Da Lio, C, Biral, M, Danelli, P, Guerci, C, Scala, D, Marino, G, De Carlis, L, Lauterio, A, De Giorgi, D, Sciannamea, G, De Manzini, N, Losurdo, P, Sangiuliano, N, Degiuli, M, Caterina, F, Del Rio, P, Bonati, E, Di Lernia, S, Ardizzone, M, Di Saverio, S, Franchi, C, Di Venere, B, Miglio, R, Cuccurullo, D, Sagnelli, C, Docimo, L, Tolone, S, Longoni, M, Faillace, G, Rondelli, F, Pennella, F, Colucci, V, Carfora, T, Muttillo, I, Picardi, B, Stefano, R, Campagnacci, R, Maurizi, A, Tricarico, F, Montagna, M, Amedeo, E, Scollica, M, Lauro, E, Laterza, E, Molinari, E, Berta, G, Bono, D, Fabozzi, M, Romano, M, Facci, E, Parini, D, Farfaglia, R, Arizzi, V, Farsi, M, Miranda, E, Fei, L, Flavio, G, Pirozzi, F, Sciuto, A, Ferrero, A, Palisi, M, Filauro, M, Barberis, A, Azzinnaro, A, Fiscon, V, Vigna, S, D'Ambra, M, Pontecorvi, E, Anania, G, Bombardini, C, Galizia, G, Auricchio, A, Cardella, F, Genna, M, Gentilli, S, Herald, N, Castagnoli, G, Bartoli, A, Gianotti, L, Garancini, M, Bellanova, G, Palazzo, P, De Palma, G, Milone, M, Ferrari, G, Magistro, C, Giuliani, A, Di Natale, G, Brisinda, G, Cavallaro, G, Sammarco, G, Gallo, G, Goletti, O, Macchini, D, Greco, V, Amoroso, V, Guercioni, G, Benedetti, M, Guzzo, G, Pata, F, Scandroglio, I, Roscio, F, Jovine, E, Lombardi, R, La Rocca, F, Di Capua, F, Lanci, C, Leli, R, Borasi, A, Lepiane, P, Balla, A, Liberatore, E, Morelli, L, Di Franco, G, Lucchi, A, Vittori, L, Bonavina, L, Asti, E, Maggioni, D, Martino, G, Manca, G, Delvecchio, A, Tedesco, M, Gambardella, D, Marafioti, S, De Marco, M, Guicciardi, M, Motta, M, Calgaro, M, Adamo, V, Guerrieri, M, Coletta, P, Ortenzi, M, Martines, G, Lantone, G, Martinotti, M, Fassardi, G, Castriconi, M, Squillante, S, De Luca, M, Pavanello, M, Di Marco, C, Ronconi, M, Casiraghi, S, Mazzaferro, V, Battiston, C, Perrotta, M, Ripa, C, Giancarlo, M, Panizzo, V, Millo, P, Contul, R, Ferraro, V, Molino, C, Crolla, E, Moretto, G, Bacchion, M, Morino, M, Allaix, M, Motterlini, E, Petracca, M, Muratore, A, Musella, M, Vitiello, A, Nardo, B, Crocco, V, Navarra, G, Lazzara, S, Cuoghi, M, Olmi, S, Oldani, A, Uccelli, M, Opocher, E, Giovenzana, M, De Paolis, P, Santarelli, M, Delrio, P, Carbone, F, Bianchi, P, Formisano, Capelli, P, Baldini, E, Festa, P, Mottola, A, Merola, G, Perrotta, N, Celiento, M, Personnettaz, E, Muzio, S, Petitti, T, Melchiorre, A, Piccoli, M, Pecchini, F, Frontali, A, Maffioli, A, Maida, P, Tammaro, P, Pignata, G, Andreuccetti, J, Pilone, V, Renzulli, M, Pintaldi, S, Ceretti, A, Mariani, N, Pisanu, A, Polastri, R, Maiello, F, Porcu, A, Perra, T, Mucilli, F, Troisi, R, Montalti, R, Scognamillo, F, Delogu, D, Galleano, R, Malerba, M, Salfi, R, Pisano, M, Sechi, R, Cillara, N, Ramuscello, S, De Leo, E, Restini, E, Tumolo, R, Cianci, P, Capuzzolo, S, Rizzo, M, Recordare, A, Santoro, R, Amodio, P, Rocca, A, Cecere, G, Romito, R, Portigliotti, L, Rosati, R, Elmore, U, Russello, D, Latteri, S, Costarella, S, Massa, S, Capasso, L, Santangelo, M, Sodo, M, Sarro, G, Rivolta, U, Scabini, S, Pertile, D, Selvaggi, F, Rossi, S, Pellino, G, Sganga, G, Fransvea, P, Testa, S, De Rosa, C, Siquini, W, Trana, C, Solej, M, Bolzon, S, Guerra, E, Stella, M, Ferrara, F, Stipa, F, Stringhi, E, Celotti, A, Taglietti, L, Del Giudice, R, Talarico, C, Ruggiero, M, Tirone, G, Romario, U, Petz, W, Caracino, V, Rossetti, V, Verza, L, Vescovi, L, Marini, M, Vettoretto, N, Botteri, E, Vincenti, L, Giannandrea, G, Viora, T, Maganuco, L, Veronesi, P, Zani, B, Zanus, G, Brizzolari, M, Zanzi, F, Guariniello, A, Zappa, M, Galfrascoli, E, Zonta, S, Oragano, L, Zuliani, W, Chiari, D, Bracale U., Podda M., Castiglioni S., Peltrini R., Sartori A., Arezzo A., Corcione F., Agresta F., Antonucci A., Zanframundo C., Cavallo F., Mazzarolo G., Agrusa A., Di Buono G., Aldrighetti L., Fiorentini G., Lucianetti A., Magnone S., Alfieri S., Rosa F., Altomare D. F., Picciariello A., Parisi A., Di Cintio A., Amisano M. F., Cravero F., Ammendola M., Ammerata G., Anastasi A., Canonico G., Gattolin A., Travaglio E., De Palma M., Angelini P., Galante F., Benevento A., Rausei S., Serao A., Abbatini F., Annecchiarico M., Varricchio A., Annessi V., Tumiati D., Annicchiarico A., Mirabella A., Marino M. V., Spinelli A., Braun A., Santi H. T., Romano L., Antoniutti M., Armellino M. F., Argenio G., Verzelli A., Budassi A., Baiocchi G., Alfano M. S., Balani A., Barone M., Baldazzi G., Cassini D., Canger R. C. B., Zabbialini G., Belli A., Izzo F., Bertolino F., Brunetti M., Bianco F., Cappiello A., Boccia L., Boffi B., Perna F., Bonilauri S., Frazzetta G., Bordoni P., Fleres F., Borghi F., Giraudo G., Bottino V., Canfora A., Piccoli F. B., Calligaris L., Nipote B., Nasti A. G., Bufalari A., Bettarini F., Buononato M., Greco M., Calo P. G., Medas F., Cardamone E., Castaldo P., Carlini M., Spoletini D., De Nisco C., Pulighe F., Feo C. V., Fabbri N., Antropoli C., Foroni F., Carnazza M., Ragazzi S., Cassinotti E., Boni L., Catena F., Giuffrida M., Perrone G., Ccotsoglou C., Granieri S., Ceccarelli G., Bugiantella W., Cedolini C., Seriau L., Cesari M., Contine A., Chiara O., Cimbanassi S., Cocozza E., Berselli M., Fantini C., Costi R., Casali L., Morini A., Crafa F., Vanela S., Curro G., Orsini V., Da Lio C., Biral M., Danelli P., Guerci C., Scala D., Marino G., De Carlis L., Lauterio A., De Giorgi D., Sciannamea G., De Manzini N., Losurdo P., Sangiuliano N., Degiuli M., Caterina F., Del Rio P., Bonati E., Di Lernia S., Ardizzone M. V. R., Di Saverio S., Franchi C., Di Venere B., Miglio R., Cuccurullo D., Sagnelli C., Docimo L., Tolone S., Longoni M., Faillace G., Rondelli F., Pennella F. P., Colucci V., Carfora T., Muttillo I. A., Picardi B., Stefano R., Campagnacci R., Maurizi A., Tricarico F., Montagna M., Amedeo E., Scollica M. C., Lauro E., Laterza E., Molinari E., Berta G., Bono D., Fabozzi M., Romano M., Facci E., Parini D., Farfaglia R., Arizzi V., Farsi M., Miranda E., Fei L., Flavio G., Pirozzi F., Sciuto A., Ferrero A., Palisi M., Filauro M., Barberis A., Azzinnaro A., Fiscon V., Vigna S., D'ambra M., Pontecorvi E., Anania G., Bombardini C., Galizia G., Auricchio A., Cardella F., Genna M., Gentilli S., Herald N., Castagnoli G., Bartoli A., Gianotti L., Garancini M., Bellanova G., Palazzo P., De Palma G., Milone M., Ferrari G., Magistro C., Giuliani A., Di Natale G., Brisinda G., Cavallaro G., Sammarco G., Gallo G., Goletti O., Macchini D., Greco V., Amoroso V., Guercioni G., Benedetti M., Guzzo G., Pata F., Scandroglio I., Roscio F., Jovine E., Lombardi R., La Rocca F., Di Capua F., Lanci C., Leli R., Borasi A., Lepiane P., Balla A., Liberatore E., Morelli L., Di Franco G., Lucchi A., Vittori L., Bonavina L., Asti E., Maggioni D., Martino G., Manca G., Delvecchio A., Tedesco M., Gambardella D., Marafioti S., De Marco M. L., Guicciardi M. A., Motta M., Calgaro M., Adamo V., Guerrieri M., Coletta P., Ortenzi M., Martines G., Lantone G., Martinotti M., Fassardi G., Castriconi M., Squillante S., De Luca M., Pavanello M., Di Marco C., Ronconi M., Casiraghi S., Mazzaferro V., Battiston C., Perrotta M., Ripa C., Giancarlo M., Panizzo V., Millo P., Contul R. B., Ferraro V., Molino C., Crolla E., Moretto G., Bacchion M., Morino M., Allaix M. E., Motterlini E., Petracca M., Muratore A., Musella M., Vitiello A., Nardo B., Crocco V., Navarra G., Lazzara S., Navarra G. G., Cuoghi M., Olmi S., Oldani A., Uccelli M., Opocher E., Giovenzana M., De Paolis P., Santarelli M., Delrio P., Carbone F., Bianchi P. P. G., Capelli P., Baldini E., Festa P., Mottola A., Merola G., Perrotta N., Celiento M., Personnettaz E., Muzio S., Petitti T., Melchiorre A., Piccoli M., Pecchini F., Frontali A., Maffioli A., Maida P., Tammaro P., Pignata G., Andreuccetti J., Pilone V., Renzulli M., Pintaldi S., Ceretti A. P., Mariani N. M., Pisanu A., Polastri R., Maiello F., Porcu A., Perra T., Mucilli F., Troisi R., Montalti R., Scognamillo F., Delogu D., Galleano R., Malerba M., Salfi R., Pisano M., Sechi R., Cillara N., Ramuscello S., De Leo E., Restini E., Tumolo R., Cianci P., Capuzzolo S., Rizzo M., Recordare A., Santoro R., Amodio P. M., Rocca A., Cecere G., Romito R., Portigliotti L., Rosati R., Elmore U., Russello D., Latteri S., Costarella S. M., Massa S., Capasso L., Santangelo M., Sodo M., Sarro G., Rivolta U., Scabini S., Pertile D., Selvaggi F., Rossi S., Pellino G., Sganga G., Fransvea P., Testa S., De Rosa C., Siquini W., Trana C., Solej M., Bolzon S., Guerra E., Stella M., Ferrara F., Stipa F., Stringhi E., Celotti A., Taglietti L., Del Giudice R., Talarico C. A., Ruggiero M., Tirone G., Romario U. F., Petz W., Caracino V., Rossetti V., Verza L. A., Vescovi L., Marini M., Vettoretto N., Botteri E., Vincenti L., Giannandrea G., Viora T., Maganuco L., Veronesi P., Zani B., Zanus G., Brizzolari M., Zanzi F., Guariniello A., Zappa M. A., Galfrascoli E., Zonta S., Oragano L., Zuliani W., and Chiari D.

Abstract

Background: The spread of the SARS-CoV2 virus, which causes COVID-19 disease, profoundly impacted the surgical community. Recommendations have been published to manage patients needing surgery during the COVID-19 pandemic. This survey, under the aegis of the Italian Society of Endoscopic Surgery, aims to analyze how Italian surgeons have changed their practice during the pandemic. Methods: The authors designed an online survey that was circulated for completion to the Italian departments of general surgery registered in the Italian Ministry of Health database in December 2020. Questions were divided into three sections: hospital organization, screening policies, and safety profile of the surgical operation. The investigation periods were divided into the Italian pandemic phases I (March–May 2020), II (June–September 2020), and III (October–December 2020). Results: Of 447 invited departments, 226 answered the survey. Most hospitals were treating both COVID-19-positive and -negative patients. The reduction in effective beds dedicated to surgical activity was significant, affecting 59% of the responding units. 12.4% of the respondents in phase I, 2.6% in phase II, and 7.7% in phase III reported that their surgical unit had been closed. 51.4%, 23.5%, and 47.8% of the respondents had at least one colleague reassigned to non-surgical COVID-19 activities during the three phases. There has been a reduction in elective (> 200 procedures: 2.1%, 20.6% and 9.9% in the three phases, respectively) and emergency (< 20 procedures: 43.3%, 27.1%, 36.5% in the three phases, respectively) surgical activity. The use of laparoscopy also had a setback in phase I (25.8% performed less than 20% of elective procedures through laparoscopy). 60.6% of the respondents used a smoke evacuation device during laparoscopy in phase I, 61.6% in phase II, and 64.2% in phase III. Almost all responders (82.8% vs. 93.2% vs. 92.7%) in each analyzed period did not modify or reduce the use of high-energ

Published
2021

17. Italian contact lens practitioners’ perspective on providing and adapting contact lens practice during the COVID-19 pandemic

Author

Zeri, F, Rizzo, G, Desiato, A, Livi, S, Scarci, F, Cecalupo, A, Marini, M, Tavazzi, S, Naroo, S, Zeri F, Rizzo GC, Desiato A, Livi S, Scarci F, Cecalupo A, Marini M, Tavazzi S, Naroo SA., Zeri, F, Rizzo, G, Desiato, A, Livi, S, Scarci, F, Cecalupo, A, Marini, M, Tavazzi, S, Naroo, S, Zeri F, Rizzo GC, Desiato A, Livi S, Scarci F, Cecalupo A, Marini M, Tavazzi S, and Naroo SA.

Abstract

Purpose: In Italy, as a result of the COVID-19 pandemic, optical practices were partially closed during the first lockdown. When practices fully reopened there were changes in the way contact lens (CL) clinical practice was conducted. This study investigates the opinions of CL practitioners (CLPs) at the end of lockdown about the changes they implemented. Methods: An online survey was conducted amongst Italian CLPs after the first lockdown had ended. The anonymised questionnaire included details of demographics, clinical practice, implementation of personal protective measures and reasons for continuing or ceasing to undertake new CL fittings or aftercare visits after lockdown. Results: A total of 104 CLPs completed the questionnaire. Practitioners reported an average reduction of new CL fittings (24.8%) and aftercare visits (17.9%) compared to pre-pandemic numbers. Of the protective measures tested, the use of facemasks and an increased frequency of disinfection of instruments and working spaces were implemented more frequently; these measures were correlated with a lower level of reduction in new fittings and aftercare visits (all P < 0.001). ‘The importance of CLs to patients’ and the ‘professional duty to guarantee access to the service’ were the most important reasons for continuing to conduct new CL fittings and aftercare visits, whilst lack of demand and severity of COVID-19 were the main deterrents against conducting CL practice. In addition, the opportunity to reinforce compliance during aftercare visits was given high importance. Conclusion: The COVID-19 pandemic reduced the frequency of new CL fittings and aftercare visits following lockdown. CLPs acknowledged the importance of CLs for patients and their role in providing access to CLs, even during the challenging circumstances of the pandemic

Published
2021

18. Correction to: Changes in surgicaL behaviOrs dUring the CoviD-19 pandemic. The SICE CLOUD19 Study (Updates in Surgery, (2021), 73, 2, (731-744), 10.1007/s13304-021-01010-w)

Author

Bracale U., Bracale, U, Podda, M, Castiglioni, S, Peltrini, R, Sartori, A, Arezzo, A, Corcione, F, Agresta, F, Antonucci, A, Zanframundo, C, Cavallo, F, Mazzarolo, G, Agrusa, A, Di Buono, G, Aldrighetti, L, Fiorentini, G, Lucianetti, A, Magnone, S, Alfieri, S, Rosa, F, Altomare, D, Picciariello, A, Parisi, A, Di Cintio, A, Amisano, M, Cravero, F, Ammendola, M, Ammerata, G, Anastasi, A, Canonico, G, Gattolin, A, Travaglio, E, De Palma, M, Angelini, P, Galante, F, Benevento, A, Rausei, S, Serao, A, Abbatini, F, Annecchiarico, M, Varricchio, A, Annessi, V, Tumiati, D, Annicchiarico, A, Mirabella, A, Marino, M, Spinelli, A, Braun, A, Santi, H, Romano, L, Antoniutti, M, Armellino, M, Argenio, G, Verzelli, A, Budassi, A, Baiocchi, G, Alfano, M, Balani, A, Barone, M, Baldazzi, G, Cassini, D, Canger, R, Zabbialini, G, Belli, A, Izzo, F, Bertolino, F, Brunetti, M, Bianco, F, Cappiello, A, Boccia, L, Boffi, B, Perna, F, Bonilauri, S, Frazzetta, G, Bordoni, P, Fleres, F, Borghi, F, Giraudo, G, Bottino, V, Canfora, A, Piccoli, F, Calligaris, L, Nipote, B, Nasti, A, Bufalari, A, Bettarini, F, Buononato, M, Greco, M, Calo, P, Medas, F, Cardamone, E, Castaldo, P, Carlini, M, Spoletini, D, De Nisco, C, Pulighe, F, Feo, C, Fabbri, N, Antropoli, C, Foroni, F, Carnazza, M, Ragazzi, S, Cassinotti, E, Boni, L, Catena, F, Giuffrida, M, Perrone, G, Ccotsoglou, C, Granieri, S, Ceccarelli, G, Bugiantella, W, Cedolini, C, Seriau, L, Cesari, M, Contine, A, Chiara, O, Cimbanassi, S, Cocozza, E, Berselli, M, Fantini, C, Costi, R, Casali, L, Morini, A, Crafa, F, Vanela, S, Curro, G, Orsini, V, Da Lio, C, Biral, M, Danelli, P, Guerci, C, Scala, D, Marino, G, De Carlis, L, Lauterio, A, De Giorgi, D, Sciannamea, G, De Manzini, N, Losurdo, P, Sangiuliano, N, Degiuli, M, Caterina, F, Del Rio, P, Bonati, E, Di Lernia, S, Ardizzone, M, Di Saverio, S, Franchi, C, Di Venere, B, Miglio, R, Cuccurullo, D, Sagnelli, C, Docimo, L, Tolone, S, Longoni, M, Faillace, G, Rondelli, F, Pennella, F, Colucci, V, Carfora, T, Muttillo, I, Picardi, B, Stefano, R, Campagnacci, R, Maurizi, A, Tricarico, F, Montagna, M, Amedeo, E, Scollica, M, Lauro, E, Laterza, E, Molinari, E, Berta, G, Bono, D, Fabozzi, M, Romano, M, Facci, E, Parini, D, Farfaglia, R, Arizzi, V, Farsi, M, Miranda, E, Fei, L, Flavio, G, Pirozzi, F, Sciuto, A, Ferrero, A, Palisi, M, Filauro, M, Barberis, A, Azzinnaro, A, Fiscon, V, Vigna, S, D'Ambra, M, Pontecorvi, E, Anania, G, Bombardini, C, Galizia, G, Auricchio, A, Cardella, F, Genna, M, Gentilli, S, Herald, N, Castagnoli, G, Bartoli, A, Gianotti, L, Garancini, M, Bellanova, G, Palazzo, P, De Palma, G, Milone, M, Ferrari, G, Magistro, C, Giuliani, A, Di Natale, G, Brisinda, G, Cavallaro, G, Sammarco, G, Gallo, G, Goletti, O, Macchini, D, Greco, V, Amoroso, V, Guercioni, G, Benedetti, M, Guzzo, G, Pata, F, Scandroglio, I, Roscio, F, Jovine, E, Lombardi, R, La Rocca, F, Di Capua, F, Lanci, C, Leli, R, Borasi, A, Lepiane, P, Balla, A, Liberatore, E, Morelli, L, Di Franco, G, Lucchi, A, Vittori, L, Bonavina, L, Asti, E, Maggioni, D, Martino, G, Manca, G, Delvecchio, A, Tedesco, M, Gambardella, D, Marafioti, S, De Marco, M, Guicciardi, M, Motta, M, Calgaro, M, Adamo, V, Guerrieri, M, Coletta, P, Ortenzi, M, Martines, G, Lantone, G, Martinotti, M, Fassardi, G, Castriconi, M, Squillante, S, De Luca, M, Pavanello, M, Di Marco, C, Ronconi, M, Casiraghi, S, Mazzaferro, V, Battiston, C, Perrotta, M, Ripa, C, Giancarlo, M, Panizzo, V, Millo, P, Contul, R, Ferraro, V, Molino, C, Crolla, E, Moretto, G, Bacchion, M, Morino, M, Allaix, M, Motterlini, E, Petracca, M, Muratore, A, Musella, M, Vitiello, A, Nardo, B, Crocco, V, Navarra, G, Lazzara, S, Cuoghi, M, Olmi, S, Oldani, A, Uccelli, M, Opocher, E, Giovenzana, M, De Paolis, P, Santarelli, M, Delrio, P, Carbone, F, Bianchi, P, Formisano, G, Capelli, P, Baldini, E, Festa, P, Mottola, A, Merola, G, Perrotta, N, Celiento, M, Personnettaz, E, Muzio, S, Petitti, T, Melchiorre, A, Piccoli, M, Pecchini, F, Frontali, A, Maffioli, A, Maida, P, Tammaro, P, Pignata, G, Andreuccetti, J, Pilone, V, Renzulli, M, Pintaldi, S, Ceretti, A, Mariani, N, Pisanu, A, Polastri, R, Maiello, F, Porcu, A, Perra, T, Mucilli, F, Troisi, R, Montalti, R, Scognamillo, F, Delogu, D, Galleano, R, Malerba, M, Salfi, R, Pisano, M, Sechi, R, Cillara, N, Ramuscello, S, De Leo, E, Restini, E, Tumolo, R, Cianci, P, Capuzzolo, S, Rizzo, M, Recordare, A, Santoro, R, Amodio, P, Rocca, A, Cecere, G, Romito, R, Portigliotti, L, Rosati, R, Elmore, U, Russello, D, Latteri, S, Costarella, S, Massa, S, Capasso, L, Santangelo, M, Sodo, M, Sarro, G, Rivolta, U, Scabini, S, Pertile, D, Selvaggi, F, Rossi, S, Pellino, G, Sganga, G, Fransvea, P, Testa, S, De Rosa, C, Siquini, W, Trana, C, Solej, M, Bolzon, S, Guerra, E, Stella, M, Ferrara, F, Stipa, F, Stringhi, E, Celotti, A, Taglietti, L, Del Giudice, R, Talarico, C, Ruggiero, M, Tirone, G, Romario, U, Petz, W, Caracino, V, Rossetti, V, Verza, L, Vescovi, L, Marini, M, Vettoretto, N, Botteri, E, Vincenti, L, Giannandrea, G, Viora, T, Maganuco, L, Veronesi, P, Zani, B, Zanus, G, Brizzolari, M, Zanzi, F, Guariniello, A, Zappa, M, Galfrascoli, E, Zonta, S, Oragano, L, Zuliani, W, Chiari, D, Bracale U., Podda M., Castiglioni S., Peltrini R., Sartori A., Arezzo A., Corcione F., Agresta F., Antonucci A., Zanframundo C., Cavallo F., Mazzarolo G., Agrusa A., Di Buono G., Aldrighetti L., Fiorentini G., Lucianetti A., Magnone S., Alfieri S., Rosa F., Altomare D. F., Picciariello A., Parisi A., Di Cintio A., Amisano M. F., Cravero F., Ammendola M., Ammerata G., Anastasi A., Canonico G., Gattolin A., Travaglio E., De Palma M., Angelini P., Galante F., Benevento A., Rausei S., Serao A., Abbatini F., Annecchiarico M., Varricchio A., Annessi V., Tumiati D., Annicchiarico A., Mirabella A., Marino M. V., Spinelli A., Braun A., Santi H. T., Romano L., Antoniutti M., Armellino M. F., Argenio G., Verzelli A., Budassi A., Baiocchi G., Alfano M. S., Balani A., Barone M., Baldazzi G., Cassini D., Canger R. C. B., Zabbialini G., Belli A., Izzo F., Bertolino F., Brunetti M., Bianco F., Cappiello A., Boccia L., Boffi B., Perna F., Bonilauri S., Frazzetta G., Bordoni P., Fleres F., Borghi F., Giraudo G., Bottino V., Canfora A., Piccoli F. B., Calligaris L., Nipote B., Nasti A. G., Bufalari A., Bettarini F., Buononato M., Greco M., Calo P. G., Medas F., Cardamone E., Castaldo P., Carlini M., Spoletini D., De Nisco C., Pulighe F., Feo C. V., Fabbri N., Antropoli C., Foroni F., Carnazza M., Ragazzi S., Cassinotti E., Boni L., Catena F., Giuffrida M., Perrone G., Ccotsoglou C., Granieri S., Ceccarelli G., Bugiantella W., Cedolini C., Seriau L., Cesari M., Contine A., Chiara O., Cimbanassi S., Cocozza E., Berselli M., Fantini C., Costi R., Casali L., Morini A., Crafa F., Vanela S., Curro G., Orsini V., Da Lio C., Biral M., Danelli P., Guerci C., Scala D., Marino G., De Carlis L., Lauterio A., De Giorgi D., Sciannamea G., De Manzini N., Losurdo P., Sangiuliano N., Degiuli M., Caterina F., Del Rio P., Bonati E., Di Lernia S., Ardizzone M. V. R., Di Saverio S., Franchi C., Di Venere B., Miglio R., Cuccurullo D., Sagnelli C., Docimo L., Tolone S., Longoni M., Faillace G., Rondelli F., Pennella F. P., Colucci V., Carfora T., Muttillo I. A., Picardi B., Stefano R., Campagnacci R., Maurizi A., Tricarico F., Montagna M., Amedeo E., Scollica M. C., Lauro E., Laterza E., Molinari E., Berta G., Bono D., Fabozzi M., Romano M., Facci E., Parini D., Farfaglia R., Arizzi V., Farsi M., Miranda E., Fei L., Flavio G., Pirozzi F., Sciuto A., Ferrero A., Palisi M., Filauro M., Barberis A., Azzinnaro A., Fiscon V., Vigna S., D'ambra M., Pontecorvi E., Anania G., Bombardini C., Galizia G., Auricchio A., Cardella F., Genna M., Gentilli S., Herald N., Castagnoli G., Bartoli A., Gianotti L., Garancini M., Bellanova G., Palazzo P., De Palma G., Milone M., Ferrari G., Magistro C., Giuliani A., Di Natale G., Brisinda G., Cavallaro G., Sammarco G., Gallo G., Goletti O., Macchini D., Greco V., Amoroso V., Guercioni G., Benedetti M., Guzzo G., Pata F., Scandroglio I., Roscio F., Jovine E., Lombardi R., La Rocca F., Di Capua F., Lanci C., Leli R., Borasi A., Lepiane P., Balla A., Liberatore E., Morelli L., Di Franco G., Lucchi A., Vittori L., Bonavina L., Asti E., Maggioni D., Martino G., Manca G., Delvecchio A., Tedesco M., Gambardella D., Marafioti S., De Marco M. L., Guicciardi M. A., Motta M., Calgaro M., Adamo V., Guerrieri M., Coletta P., Ortenzi M., Martines G., Lantone G., Martinotti M., Fassardi G., Castriconi M., Squillante S., De Luca M., Pavanello M., Di Marco C., Ronconi M., Casiraghi S., Mazzaferro V., Battiston C., Perrotta M., Ripa C., Giancarlo M., Panizzo V., Millo P., Contul R. B., Ferraro V., Molino C., Crolla E., Moretto G., Bacchion M., Morino M., Allaix M. E., Motterlini E., Petracca M., Muratore A., Musella M., Vitiello A., Nardo B., Crocco V., Navarra G., Lazzara S., Navarra G. G., Cuoghi M., Olmi S., Oldani A., Uccelli M., Opocher E., Giovenzana M., De Paolis P., Santarelli M., Delrio P., Carbone F., Bianchi P. P., Formisano G., Capelli P., Baldini E., Festa P., Mottola A., Merola G., Perrotta N., Celiento M., Personnettaz E., Muzio S., Petitti T., Melchiorre A., Piccoli M., Pecchini F., Frontali A., Maffioli A., Maida P., Tammaro P., Pignata G., Andreuccetti J., Pilone V., Renzulli M., Pintaldi S., Ceretti A. P., Mariani N. M., Pisanu A., Polastri R., Maiello F., Porcu A., Perra T., Mucilli F., Troisi R., Montalti R., Scognamillo F., Delogu D., Galleano R., Malerba M., Salfi R., Pisano M., Sechi R., Cillara N., Ramuscello S., De Leo E., Restini E., Tumolo R., Cianci P., Capuzzolo S., Rizzo M., Recordare A., Santoro R., Amodio P. M., Rocca A., Cecere G., Romito R., Portigliotti L., Rosati R., Elmore U., Russello D., Latteri S., Costarella S. M., Massa S., Capasso L., Santangelo M., Sodo M., Sarro G., Rivolta U., Scabini S., Pertile D., Selvaggi F., Rossi S., Pellino G., Sganga G., Fransvea P., Testa S., De Rosa C., Siquini W., Trana C., Solej M., Bolzon S., Guerra E., Stella M., Ferrara F., Stipa F., Stringhi E., Celotti A., Taglietti L., Del Giudice R., Talarico C. A., Ruggiero M., Tirone G., Romario U. F., Petz W., Caracino V., Rossetti V., Verza L. A., Vescovi L., Marini M., Vettoretto N., Botteri E., Vincenti L., Giannandrea G., Viora T., Maganuco L., Veronesi P., Zani B., Zanus G., Brizzolari M., Zanzi F., Guariniello A., Zappa M. A., Galfrascoli E., Zonta S., Oragano L., Zuliani W., Chiari D., Bracale U., Bracale, U, Podda, M, Castiglioni, S, Peltrini, R, Sartori, A, Arezzo, A, Corcione, F, Agresta, F, Antonucci, A, Zanframundo, C, Cavallo, F, Mazzarolo, G, Agrusa, A, Di Buono, G, Aldrighetti, L, Fiorentini, G, Lucianetti, A, Magnone, S, Alfieri, S, Rosa, F, Altomare, D, Picciariello, A, Parisi, A, Di Cintio, A, Amisano, M, Cravero, F, Ammendola, M, Ammerata, G, Anastasi, A, Canonico, G, Gattolin, A, Travaglio, E, De Palma, M, Angelini, P, Galante, F, Benevento, A, Rausei, S, Serao, A, Abbatini, F, Annecchiarico, M, Varricchio, A, Annessi, V, Tumiati, D, Annicchiarico, A, Mirabella, A, Marino, M, Spinelli, A, Braun, A, Santi, H, Romano, L, Antoniutti, M, Armellino, M, Argenio, G, Verzelli, A, Budassi, A, Baiocchi, G, Alfano, M, Balani, A, Barone, M, Baldazzi, G, Cassini, D, Canger, R, Zabbialini, G, Belli, A, Izzo, F, Bertolino, F, Brunetti, M, Bianco, F, Cappiello, A, Boccia, L, Boffi, B, Perna, F, Bonilauri, S, Frazzetta, G, Bordoni, P, Fleres, F, Borghi, F, Giraudo, G, Bottino, V, Canfora, A, Piccoli, F, Calligaris, L, Nipote, B, Nasti, A, Bufalari, A, Bettarini, F, Buononato, M, Greco, M, Calo, P, Medas, F, Cardamone, E, Castaldo, P, Carlini, M, Spoletini, D, De Nisco, C, Pulighe, F, Feo, C, Fabbri, N, Antropoli, C, Foroni, F, Carnazza, M, Ragazzi, S, Cassinotti, E, Boni, L, Catena, F, Giuffrida, M, Perrone, G, Ccotsoglou, C, Granieri, S, Ceccarelli, G, Bugiantella, W, Cedolini, C, Seriau, L, Cesari, M, Contine, A, Chiara, O, Cimbanassi, S, Cocozza, E, Berselli, M, Fantini, C, Costi, R, Casali, L, Morini, A, Crafa, F, Vanela, S, Curro, G, Orsini, V, Da Lio, C, Biral, M, Danelli, P, Guerci, C, Scala, D, Marino, G, De Carlis, L, Lauterio, A, De Giorgi, D, Sciannamea, G, De Manzini, N, Losurdo, P, Sangiuliano, N, Degiuli, M, Caterina, F, Del Rio, P, Bonati, E, Di Lernia, S, Ardizzone, M, Di Saverio, S, Franchi, C, Di Venere, B, Miglio, R, Cuccurullo, D, Sagnelli, C, Docimo, L, Tolone, S, Longoni, M, Faillace, G, Rondelli, F, Pennella, F, Colucci, V, Carfora, T, Muttillo, I, Picardi, B, Stefano, R, Campagnacci, R, Maurizi, A, Tricarico, F, Montagna, M, Amedeo, E, Scollica, M, Lauro, E, Laterza, E, Molinari, E, Berta, G, Bono, D, Fabozzi, M, Romano, M, Facci, E, Parini, D, Farfaglia, R, Arizzi, V, Farsi, M, Miranda, E, Fei, L, Flavio, G, Pirozzi, F, Sciuto, A, Ferrero, A, Palisi, M, Filauro, M, Barberis, A, Azzinnaro, A, Fiscon, V, Vigna, S, D'Ambra, M, Pontecorvi, E, Anania, G, Bombardini, C, Galizia, G, Auricchio, A, Cardella, F, Genna, M, Gentilli, S, Herald, N, Castagnoli, G, Bartoli, A, Gianotti, L, Garancini, M, Bellanova, G, Palazzo, P, De Palma, G, Milone, M, Ferrari, G, Magistro, C, Giuliani, A, Di Natale, G, Brisinda, G, Cavallaro, G, Sammarco, G, Gallo, G, Goletti, O, Macchini, D, Greco, V, Amoroso, V, Guercioni, G, Benedetti, M, Guzzo, G, Pata, F, Scandroglio, I, Roscio, F, Jovine, E, Lombardi, R, La Rocca, F, Di Capua, F, Lanci, C, Leli, R, Borasi, A, Lepiane, P, Balla, A, Liberatore, E, Morelli, L, Di Franco, G, Lucchi, A, Vittori, L, Bonavina, L, Asti, E, Maggioni, D, Martino, G, Manca, G, Delvecchio, A, Tedesco, M, Gambardella, D, Marafioti, S, De Marco, M, Guicciardi, M, Motta, M, Calgaro, M, Adamo, V, Guerrieri, M, Coletta, P, Ortenzi, M, Martines, G, Lantone, G, Martinotti, M, Fassardi, G, Castriconi, M, Squillante, S, De Luca, M, Pavanello, M, Di Marco, C, Ronconi, M, Casiraghi, S, Mazzaferro, V, Battiston, C, Perrotta, M, Ripa, C, Giancarlo, M, Panizzo, V, Millo, P, Contul, R, Ferraro, V, Molino, C, Crolla, E, Moretto, G, Bacchion, M, Morino, M, Allaix, M, Motterlini, E, Petracca, M, Muratore, A, Musella, M, Vitiello, A, Nardo, B, Crocco, V, Navarra, G, Lazzara, S, Cuoghi, M, Olmi, S, Oldani, A, Uccelli, M, Opocher, E, Giovenzana, M, De Paolis, P, Santarelli, M, Delrio, P, Carbone, F, Bianchi, P, Formisano, G, Capelli, P, Baldini, E, Festa, P, Mottola, A, Merola, G, Perrotta, N, Celiento, M, Personnettaz, E, Muzio, S, Petitti, T, Melchiorre, A, Piccoli, M, Pecchini, F, Frontali, A, Maffioli, A, Maida, P, Tammaro, P, Pignata, G, Andreuccetti, J, Pilone, V, Renzulli, M, Pintaldi, S, Ceretti, A, Mariani, N, Pisanu, A, Polastri, R, Maiello, F, Porcu, A, Perra, T, Mucilli, F, Troisi, R, Montalti, R, Scognamillo, F, Delogu, D, Galleano, R, Malerba, M, Salfi, R, Pisano, M, Sechi, R, Cillara, N, Ramuscello, S, De Leo, E, Restini, E, Tumolo, R, Cianci, P, Capuzzolo, S, Rizzo, M, Recordare, A, Santoro, R, Amodio, P, Rocca, A, Cecere, G, Romito, R, Portigliotti, L, Rosati, R, Elmore, U, Russello, D, Latteri, S, Costarella, S, Massa, S, Capasso, L, Santangelo, M, Sodo, M, Sarro, G, Rivolta, U, Scabini, S, Pertile, D, Selvaggi, F, Rossi, S, Pellino, G, Sganga, G, Fransvea, P, Testa, S, De Rosa, C, Siquini, W, Trana, C, Solej, M, Bolzon, S, Guerra, E, Stella, M, Ferrara, F, Stipa, F, Stringhi, E, Celotti, A, Taglietti, L, Del Giudice, R, Talarico, C, Ruggiero, M, Tirone, G, Romario, U, Petz, W, Caracino, V, Rossetti, V, Verza, L, Vescovi, L, Marini, M, Vettoretto, N, Botteri, E, Vincenti, L, Giannandrea, G, Viora, T, Maganuco, L, Veronesi, P, Zani, B, Zanus, G, Brizzolari, M, Zanzi, F, Guariniello, A, Zappa, M, Galfrascoli, E, Zonta, S, Oragano, L, Zuliani, W, Chiari, D, Bracale U., Podda M., Castiglioni S., Peltrini R., Sartori A., Arezzo A., Corcione F., Agresta F., Antonucci A., Zanframundo C., Cavallo F., Mazzarolo G., Agrusa A., Di Buono G., Aldrighetti L., Fiorentini G., Lucianetti A., Magnone S., Alfieri S., Rosa F., Altomare D. F., Picciariello A., Parisi A., Di Cintio A., Amisano M. F., Cravero F., Ammendola M., Ammerata G., Anastasi A., Canonico G., Gattolin A., Travaglio E., De Palma M., Angelini P., Galante F., Benevento A., Rausei S., Serao A., Abbatini F., Annecchiarico M., Varricchio A., Annessi V., Tumiati D., Annicchiarico A., Mirabella A., Marino M. V., Spinelli A., Braun A., Santi H. T., Romano L., Antoniutti M., Armellino M. F., Argenio G., Verzelli A., Budassi A., Baiocchi G., Alfano M. S., Balani A., Barone M., Baldazzi G., Cassini D., Canger R. C. B., Zabbialini G., Belli A., Izzo F., Bertolino F., Brunetti M., Bianco F., Cappiello A., Boccia L., Boffi B., Perna F., Bonilauri S., Frazzetta G., Bordoni P., Fleres F., Borghi F., Giraudo G., Bottino V., Canfora A., Piccoli F. B., Calligaris L., Nipote B., Nasti A. G., Bufalari A., Bettarini F., Buononato M., Greco M., Calo P. G., Medas F., Cardamone E., Castaldo P., Carlini M., Spoletini D., De Nisco C., Pulighe F., Feo C. V., Fabbri N., Antropoli C., Foroni F., Carnazza M., Ragazzi S., Cassinotti E., Boni L., Catena F., Giuffrida M., Perrone G., Ccotsoglou C., Granieri S., Ceccarelli G., Bugiantella W., Cedolini C., Seriau L., Cesari M., Contine A., Chiara O., Cimbanassi S., Cocozza E., Berselli M., Fantini C., Costi R., Casali L., Morini A., Crafa F., Vanela S., Curro G., Orsini V., Da Lio C., Biral M., Danelli P., Guerci C., Scala D., Marino G., De Carlis L., Lauterio A., De Giorgi D., Sciannamea G., De Manzini N., Losurdo P., Sangiuliano N., Degiuli M., Caterina F., Del Rio P., Bonati E., Di Lernia S., Ardizzone M. V. R., Di Saverio S., Franchi C., Di Venere B., Miglio R., Cuccurullo D., Sagnelli C., Docimo L., Tolone S., Longoni M., Faillace G., Rondelli F., Pennella F. P., Colucci V., Carfora T., Muttillo I. A., Picardi B., Stefano R., Campagnacci R., Maurizi A., Tricarico F., Montagna M., Amedeo E., Scollica M. C., Lauro E., Laterza E., Molinari E., Berta G., Bono D., Fabozzi M., Romano M., Facci E., Parini D., Farfaglia R., Arizzi V., Farsi M., Miranda E., Fei L., Flavio G., Pirozzi F., Sciuto A., Ferrero A., Palisi M., Filauro M., Barberis A., Azzinnaro A., Fiscon V., Vigna S., D'ambra M., Pontecorvi E., Anania G., Bombardini C., Galizia G., Auricchio A., Cardella F., Genna M., Gentilli S., Herald N., Castagnoli G., Bartoli A., Gianotti L., Garancini M., Bellanova G., Palazzo P., De Palma G., Milone M., Ferrari G., Magistro C., Giuliani A., Di Natale G., Brisinda G., Cavallaro G., Sammarco G., Gallo G., Goletti O., Macchini D., Greco V., Amoroso V., Guercioni G., Benedetti M., Guzzo G., Pata F., Scandroglio I., Roscio F., Jovine E., Lombardi R., La Rocca F., Di Capua F., Lanci C., Leli R., Borasi A., Lepiane P., Balla A., Liberatore E., Morelli L., Di Franco G., Lucchi A., Vittori L., Bonavina L., Asti E., Maggioni D., Martino G., Manca G., Delvecchio A., Tedesco M., Gambardella D., Marafioti S., De Marco M. L., Guicciardi M. A., Motta M., Calgaro M., Adamo V., Guerrieri M., Coletta P., Ortenzi M., Martines G., Lantone G., Martinotti M., Fassardi G., Castriconi M., Squillante S., De Luca M., Pavanello M., Di Marco C., Ronconi M., Casiraghi S., Mazzaferro V., Battiston C., Perrotta M., Ripa C., Giancarlo M., Panizzo V., Millo P., Contul R. B., Ferraro V., Molino C., Crolla E., Moretto G., Bacchion M., Morino M., Allaix M. E., Motterlini E., Petracca M., Muratore A., Musella M., Vitiello A., Nardo B., Crocco V., Navarra G., Lazzara S., Navarra G. G., Cuoghi M., Olmi S., Oldani A., Uccelli M., Opocher E., Giovenzana M., De Paolis P., Santarelli M., Delrio P., Carbone F., Bianchi P. P., Formisano G., Capelli P., Baldini E., Festa P., Mottola A., Merola G., Perrotta N., Celiento M., Personnettaz E., Muzio S., Petitti T., Melchiorre A., Piccoli M., Pecchini F., Frontali A., Maffioli A., Maida P., Tammaro P., Pignata G., Andreuccetti J., Pilone V., Renzulli M., Pintaldi S., Ceretti A. P., Mariani N. M., Pisanu A., Polastri R., Maiello F., Porcu A., Perra T., Mucilli F., Troisi R., Montalti R., Scognamillo F., Delogu D., Galleano R., Malerba M., Salfi R., Pisano M., Sechi R., Cillara N., Ramuscello S., De Leo E., Restini E., Tumolo R., Cianci P., Capuzzolo S., Rizzo M., Recordare A., Santoro R., Amodio P. M., Rocca A., Cecere G., Romito R., Portigliotti L., Rosati R., Elmore U., Russello D., Latteri S., Costarella S. M., Massa S., Capasso L., Santangelo M., Sodo M., Sarro G., Rivolta U., Scabini S., Pertile D., Selvaggi F., Rossi S., Pellino G., Sganga G., Fransvea P., Testa S., De Rosa C., Siquini W., Trana C., Solej M., Bolzon S., Guerra E., Stella M., Ferrara F., Stipa F., Stringhi E., Celotti A., Taglietti L., Del Giudice R., Talarico C. A., Ruggiero M., Tirone G., Romario U. F., Petz W., Caracino V., Rossetti V., Verza L. A., Vescovi L., Marini M., Vettoretto N., Botteri E., Vincenti L., Giannandrea G., Viora T., Maganuco L., Veronesi P., Zani B., Zanus G., Brizzolari M., Zanzi F., Guariniello A., Zappa M. A., Galfrascoli E., Zonta S., Oragano L., Zuliani W., and Chiari D.

Abstract

The Collaborative Group there are two authors names are incorrect. The correct names are provided below: Paolo Pietro Bianchi and Giampaolo Formisano Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence.

Published
2021

19. Communication in a threshold public goods game under ambiguity

Author

Marini, M, Garcia-Gallego, A, Corazzini, L, Marini M. M., Garcia-Gallego A., Corazzini L., Marini, M, Garcia-Gallego, A, Corazzini, L, Marini M. M., Garcia-Gallego A., and Corazzini L.

Abstract

This paper offers evidence on the impact of communication on the provision of public goods whose quality is uncertain, such as investment in prevention or fundraising in favour of non-governmental organizations (NGO). We run a laboratory experiment with two treatments, where the control variable is pre-play communication via unrestricted text chat. A binary threshold public goods game with four-person groups, threshold of three contributors and provision mechanism with elements of ambiguity is at the core of the design. A private signal linked to the real value of the public good supports the contribution decision. We find that unexpected low-valued public goods can undermine future willingness to contribute, although the benefits of communication still prevail in the form of higher public good provision. We also detect unprecedented inefficiency coming from overcontribution, given that subjects tend to neglect the free-rider problem. Chat analysis reveals that players favour the minimization of ambiguity over the maximization of the group earnings, so that we finally speculate that under uncertainty satisficing is more salient than optimizing.

Published
2020

20. Clinical management and patient outcomes of acute lower gastrointestinal bleeding. A multicenter, prospective, cohort study

Author

Radaelli, F., Frazzoni, L., Repici, A., Rondonotti, E., Mussetto, A., Feletti, V., Spada, Cristiano, Manes, G., Segato, S., Grassi, Elisa Maria, Musso, A., Di Giulio, E., Coluccio, C., Manno, M., De Nucci, G., Festa, V., Di Leo, A., Marini, Martina, Ferraris, L., Feliziani, M., Amato, A., Soriani, P., Del Bono, C., Paggi, S., Hassan, Cesare, Fuccio, L., Spada C. (ORCID:0000-0002-5692-0960), Grassi E. (ORCID:0000-0002-8456-3702), Marini M., Hassan C., Radaelli, F., Frazzoni, L., Repici, A., Rondonotti, E., Mussetto, A., Feletti, V., Spada, Cristiano, Manes, G., Segato, S., Grassi, Elisa Maria, Musso, A., Di Giulio, E., Coluccio, C., Manno, M., De Nucci, G., Festa, V., Di Leo, A., Marini, Martina, Ferraris, L., Feliziani, M., Amato, A., Soriani, P., Del Bono, C., Paggi, S., Hassan, Cesare, Fuccio, L., Spada C. (ORCID:0000-0002-5692-0960), Grassi E. (ORCID:0000-0002-8456-3702), Marini M., and Hassan C.

Abstract

Background & aim: Although acute lower GI bleeding (LGIB) represents a significant healthcare burden, prospective real-life data on management and outcomes are scanty. Present multicentre, prospective cohort study was aimed at evaluating mortality and associated risk factors and at describing patient management. Methods: Adult outpatients acutely admitted for or developing LGIB during hospitalization were consecutively enrolled in 15 high-volume referral centers. Demographics, comorbidities, medications, interventions and outcomes were recorded. Results: Overall 1,198 patients (1060 new admissions;138 inpatients) were included. Most patients were elderly (mean-age 74±15 years), 31% had a Charlson-Comorbidity-Index ≥3, 58% were on antithrombotic therapy. In-hospital mortality (primary outcome) was 3.4% (95%CI 2.5–4.6). At logistic regression analysis, independent predictors of mortality were increasing age, comorbidity, inpatient status, hemodynamic instability at presentation, and ICU-admission. Colonoscopy had a 78.8% diagnostic yield, with significantly higher hemostasis rate when performed within 24-hours than later (21.3% vs.10.8%, p = 0.027). Endoscopic hemostasis was associated with neither in-hospital mortality nor rebleeding. A definite or presumptive source of bleeding was disclosed in 90.4% of investigated patients. Conclusion: Mortality in LGIB patients is mainly related to age and comorbidities. Although early colonoscopy has a relevant diagnostic yield and is associated with higher therapeutic intervention rate, endoscopic hemostasis is not associated with improved clinical outcomes [ClinicalTrial.gov number: NCT 04364412].

Published
2021

21. Clinical management and patient outcomes of acute lower gastrointestinal bleeding. A multicenter, prospective, cohort study

Author

Radaelli, F., Frazzoni, L., Repici, A., Rondonotti, E., Mussetto, A., Feletti, V., Spada, Cristiano, Manes, G., Segato, S., Grassi, Elisa Maria, Musso, A., Di Giulio, E., Coluccio, C., Manno, M., De Nucci, G., Festa, V., Di Leo, A., Marini, Martina, Ferraris, L., Feliziani, M., Amato, Arianna, Soriani, P., Del Bono, C., Paggi, S., Hassan, Cesare, Fuccio, L., Spada C. (ORCID:0000-0002-5692-0960), Grassi E. (ORCID:0000-0002-8456-3702), Marini M., Amato A., Hassan C., Radaelli, F., Frazzoni, L., Repici, A., Rondonotti, E., Mussetto, A., Feletti, V., Spada, Cristiano, Manes, G., Segato, S., Grassi, Elisa Maria, Musso, A., Di Giulio, E., Coluccio, C., Manno, M., De Nucci, G., Festa, V., Di Leo, A., Marini, Martina, Ferraris, L., Feliziani, M., Amato, Arianna, Soriani, P., Del Bono, C., Paggi, S., Hassan, Cesare, Fuccio, L., Spada C. (ORCID:0000-0002-5692-0960), Grassi E. (ORCID:0000-0002-8456-3702), Marini M., Amato A., and Hassan C.

Abstract

Background & aim: Although acute lower GI bleeding (LGIB) represents a significant healthcare burden, prospective real-life data on management and outcomes are scanty. Present multicentre, prospective cohort study was aimed at evaluating mortality and associated risk factors and at describing patient management. Methods: Adult outpatients acutely admitted for or developing LGIB during hospitalization were consecutively enrolled in 15 high-volume referral centers. Demographics, comorbidities, medications, interventions and outcomes were recorded. Results: Overall 1,198 patients (1060 new admissions;138 inpatients) were included. Most patients were elderly (mean-age 74±15 years), 31% had a Charlson-Comorbidity-Index ≥3, 58% were on antithrombotic therapy. In-hospital mortality (primary outcome) was 3.4% (95%CI 2.5–4.6). At logistic regression analysis, independent predictors of mortality were increasing age, comorbidity, inpatient status, hemodynamic instability at presentation, and ICU-admission. Colonoscopy had a 78.8% diagnostic yield, with significantly higher hemostasis rate when performed within 24-hours than later (21.3% vs.10.8%, p = 0.027). Endoscopic hemostasis was associated with neither in-hospital mortality nor rebleeding. A definite or presumptive source of bleeding was disclosed in 90.4% of investigated patients. Conclusion: Mortality in LGIB patients is mainly related to age and comorbidities. Although early colonoscopy has a relevant diagnostic yield and is associated with higher therapeutic intervention rate, endoscopic hemostasis is not associated with improved clinical outcomes [ClinicalTrial.gov number: NCT 04364412].

Published
2021

22. Agreement in Infant Growth Indicators and Overweight/Obesity between Community and Clinical Care Settings

Author

Harris, Holly, Kling, SMR, Marini, M, Hassink, SG, Bailey-Davis, L, Savage, JS, Harris, Holly, Kling, SMR, Marini, M, Hassink, SG, Bailey-Davis, L, and Savage, JS

Abstract

Background: Infants from low-income backgrounds receive nutrition care from both community and clinical care settings. However, mothers accessing these services have reported receiving conflicting messages related to infant growth between settings, although this has not been examined quantitatively. Objective: Describe the agreement in infant growth assessments between community (Special Supplemental Nutrition Program for Women, Infants, and Children) and clinical (primary care providers) care settings. Design: A cross-sectional, secondary data analysis of infant growth measures abstracted from electronic data management systems. Participants and setting: Participants included a convenience sample of infants (N = 129) from northeastern Pennsylvania randomized to the WEE Baby Care study from July 2016 to May 2018. Infants had complete anthropometric data from both community and clinical settings at age 6.2 ± 0.4 months. Average time between assessments was 2.7 ± 1.9 weeks. Main outcome measures: Limits of agreement and bias in weight-for-age, length-for-age, weight-for-length, and body-mass-index-for-age z scores as well as cross-context equivalence in weight status between care settings. Statistical analysis performed: Bland-Altman analyses were used to describe the limits of agreement and bias in z scores between care settings. Cross-context equivalence was examined by dichotomizing infants’ growth indicators at the 85th and 95th percentile cut-points and cross-tabulating equivalent and discordant categorization between settings. Results: Strongest agreement was observed for weight-for-age z scores (95% limits of agreement –0.41 to 0.54). However, the limits of agreement intervals for growth indicators that included length were wider, suggesting weaker agreement. There was a high level of inconsistency for classification of overweight/obesity using weight-for-length z scores, with 15.5% (85th percentile cut-point) and 11.6% (95th percentile cut-point) discordant

Published
2021

23. Narrative analysis of the impact of covid-19 on patients with chronic obstructive pulmonary disease, their caregivers, and healthcare professionals in italy

Author

Volpato, Eleonora, Centanni, S., Banfi, P., D'Antonio, S., Peterle, E., Bugliaro, F., Grattagliano, I., Piraino, A., Cavalieri, L., Pennisi, Mariano Alberto, Danesi, G., Santoiemma, L., Marini, M. G., Volpato E. (ORCID:0000-0003-0266-6386), Pennisi A. (ORCID:0000-0001-8761-5144), Volpato, Eleonora, Centanni, S., Banfi, P., D'Antonio, S., Peterle, E., Bugliaro, F., Grattagliano, I., Piraino, A., Cavalieri, L., Pennisi, Mariano Alberto, Danesi, G., Santoiemma, L., Marini, M. G., Volpato E. (ORCID:0000-0003-0266-6386), and Pennisi A. (ORCID:0000-0001-8761-5144)

Abstract

Purpose: The COVID-19 pandemic has disrupted many lives, including those of people suffering from chronic obstructive pulmonary disease (COPD) and their caregivers. The main aim of this study was to use narrative medicine, a validated approach promoting quality of care to explore how the COVID-19 pandemic impacted the quality of care, quality of life, psychological factors and social factors of people affected by COPD and their caregivers and healthcare professionals (HCPs). A secondary aim was to explore the role of telemedicine in combating isolation and providing access to care. Methods: A cross-sectional observational narrative medicine study was conducted between July and November 2020 across Italy. An online semi-structured questionnaire with a narrative plot was completed by 146 participants (79 COPD patients, 24 caregivers, and 43 HCPs). Narrations were analyzed with descriptive statistics and evaluated using NVivo 11 software to break down the text and identify recurring themes and major semantic clusters. Results: During the first lockdown, 58.22% of responses from COPD patients indicated terror, fear and/or apprehension; at reopening, this figure was 35.44%. Among caregivers, these figures were 100% at first lockdown and 45.83% at reopening. The metaphors most commonly used by patients to describe COPD and COVID-19 were monster and murderer, respectively. Patients described their homes more often as clean and lonely than as offering no shelter. The narratives of 42 COPD patients (45.2%) described coping. Only 12.6% of COPD patients reported regular access to medical visits during lockdown, while 59.1% of general practitioners and pulmonologists reported using telemedicine, which was perceived as satisfactory by both patients and caregivers. Conclusion: It is relevant to aim for a multidisciplinary and multilevel system of care that empowers telemedicine and integrates specific psychological support programs for COPD patients and their caregivers.

Published
2021

24. Changes in surgicaL behaviOrs dUring the CoviD-19 pandemic. The SICE CLOUD19 Study

Author

Bracale, U., Podda, Maria Vittoria, Castiglioni, S., Peltrini, R., Sartori, Alessandra, Arezzo, A., Corcione, F., Agresta, F., Antonucci, A., Zanframundo, C., Cavallo, F., Mazzarolo, G., Agrusa, A., Di Buono, G., Aldrighetti, L., Fiorentini, G., Lucianetti, A., Magnone, S., Alfieri, Sergio, Rosa, Fausto, Altomare, D. F., Picciariello, A., Parisi, Carmelo Maria Antonio, Di Cintio, A., Amisano, M. F., Cravero, F., Ammendola, M., Ammerata, G., Anastasi, A., Canonico, G., Gattolin, A., Travaglio, E., De Palma, M., Angelini, P., Galante, F., Benevento, A., Rausei, S., Serao, A., Abbatini, F., Annecchiarico, M., Varricchio, A., Annessi, V., Tumiati, D., Annicchiarico, A., Mirabella, A., Marino, M. V., Spinelli, A., Braun, A., Santi, H. T., Romano, L., Antoniutti, M., Armellino, M. F., Argenio, G., Verzelli, A., Budassi, A., Baiocchi, G., Alfano, M. S., Balani, A., Barone, M., Baldazzi, G., Cassini, D., Canger, R. C. B., Zabbialini, G., Belli, Andrea, Izzo, Filippo, Bertolino, F., Brunetti, Maria Mercede, Bianco, Flaviana, Cappiello, A., Boccia, L., Boffi, B., Perna, Francesco, Bonilauri, S., Frazzetta, G., Bordoni, P., Fleres, F., Borghi, F., Giraudo, G., Bottino, V., Canfora, A., Piccoli, F. B., Calligaris, L., Nipote, B., Nasti, A. G., Bufalari, A., Bettarini, F., Buononato, M., Greco, M., Calo, P. G., Medas, F., Cardamone, E., Castaldo, P., Carlini, M., Spoletini, D., De Nisco, C., Pulighe, F., Feo, C. V., Fabbri, N., Antropoli, C., Foroni, F., Carnazza, M., Ragazzi, S., Cassinotti, E., Boni, L., Catena, F., Giuffrida, M., Perrone, Giuseppe, Ccotsoglou, C., Granieri, S., Ceccarelli, G., Bugiantella, W., Cedolini, C., Seriau, L., Cesari, Matteo, Contine, A., Chiara, Osvaldo, Cimbanassi, S., Cocozza, E., Berselli, M., Fantini, C., Costi, R., Casali, L., Morini, A., Crafa, F., Vanela, S., Curro, G., Orsini, V., Da Lio, C., Biral, Maria Francesca, Danelli, P., Guerci, C., Scala, D., Marino, Giuseppe, De Carlis, L., Lauterio, A., De Giorgi, D., Sciannamea, G., De Manzini, N., Losurdo, P., Sangiuliano, N., Degiuli, M., Caterina, F., Del Rio, P., Bonati, E., Di Lernia, S., Ardizzone, M. V. R., Di Saverio, S., Franchi, C., Di Venere, B., Miglio, R., Cuccurullo, D., Sagnelli, C., Docimo, L., Tolone, S., Longoni, M., Faillace, G., Rondelli, F., Pennella, F. P., Colucci, V., Carfora, T., Muttillo, I. A., Picardi, B., Stefano, R., Campagnacci, R., Maurizi, A., Tricarico, F., Montagna, M., Amedeo, E., Scollica, M. C., Lauro, E., Laterza, E., Molinari, E., Berta, G., Bono, D., Fabozzi, Simone Michele, Romano, M., Facci, E., Parini, D., Farfaglia, R., Arizzi, V., Farsi, M., Miranda, E., Fei, L., Flavio, G., Pirozzi, F., Sciuto, A., Ferrero, A., Palisi, M., Filauro, M., Barberis, A., Azzinnaro, A., Fiscon, V., Vigna, S., D'Ambra, M., Pontecorvi, E., Anania, G., Bombardini, C., Galizia, G., Auricchio, Anna Maria, Cardella, F., Genna, M., Gentilli, S., Herald, N., Castagnoli, G., Bartoli, A., Gianotti, L., Garancini, M., Bellanova, G., Palazzo, P., De Palma, G., Milone, Maria, Ferrari, G., Magistro, C., Giuliani, Antonio, Di Natale, Maria Grazia, Brisinda, Giuseppe, Cavallaro, G., Sammarco, G., Gallo, Giuseppe, Goletti, O., Macchini, D., Greco, Viviana, Amoroso, V., Guercioni, G., Benedetti, M., Guzzo, G., Pata, F., Scandroglio, I., Roscio, F., Jovine, E., Lombardi, Roberto, La Rocca, F., Di Capua, F., Lanci, C., Leli, R., Borasi, A., Lepiane, P., Balla, A., Liberatore, E., Morelli, L., Di Franco, G., Lucchi, A., Vittori, L., Bonavina, L., Asti, Emilio Fabrizio, Maggioni, D., Martino, G., Manca, Gavina, Delvecchio, A., Tedesco, M., Gambardella, D., Marafioti, S., De Marco, M. L., Guicciardi, M. A., Motta, M., Calgaro, M., Adamo, V., Guerrieri, Maria Chiara, Coletta, P., Ortenzi, M., Martines, G., Lantone, G., Martinotti, M., Fassardi, G., Castriconi, M., Squillante, S., De Luca, M., Pavanello, M., Di Marco, C., Ronconi, M., Casiraghi, Maria Stella, Mazzaferro, V., Battiston, C., Perrotta, M., Ripa, C., Giancarlo, M., Panizzo, V., Millo, P., Contul, R. B., Ferraro, V., Molino, C., Crolla, E., Moretto, G., Bacchion, M., Morino, M., Allaix, M. E., Motterlini, E., Petracca, Martina, Muratore, A., Musella, Martina, Vitiello, A., Nardo, B., Crocco, V., Navarra, G., Lazzara, S., Navarra, G. G., Cuoghi, M., Olmi, S., Oldani, Alberto, Uccelli, M., Opocher, E., Giovenzana, M., De Paolis, P., Santarelli, M., Delrio, P., Carbone, F., Bianchi, P. P. G., Formisano, Capelli, P., Baldini, E., Festa, P., Mottola, Armando, Merola, G., Perrotta, N., Celiento, M., Personnettaz, E., Muzio, S., Petitti, T., Melchiorre, A., Piccoli, M., Pecchini, F., Frontali, A., Maffioli, A., Maida, P., Tammaro, P., Pignata, G., Andreuccetti, J., Pilone, V., Renzulli, M., Pintaldi, S., Ceretti, A. P., Mariani, N. M., Pisanu, A., Polastri, R., Maiello, F., Porcu, A., Perra, T., Mucilli, F., Troisi, R., Montalti, R., Scognamillo, F., Delogu, D., Galleano, R., Malerba, M., Salfi, R., Pisano, M., Sechi, R., Cillara, N., Ramuscello, S., De Leo, E., Restini, E., Tumolo, R., Cianci, P., Capuzzolo, S., Rizzo, M., Recordare, A., Santoro, Roberto, Amodio, P. M., Rocca, A., Cecere, G., Romito, R., Portigliotti, L., Rosati, R., Elmore, U., Russello, D., Latteri, S., Costarella, S. M., Massa, S., Capasso, L., Santangelo, M., Sodo, M., Sarro, G., Rivolta, U., Scabini, S., Pertile, D., Selvaggi, F., Rossi, S., Pellino, G., Sganga, Gabriele, Fransvea, P., Testa, S., De Rosa, Maria Cristina, Siquini, W., Trana, C., Solej, M., Bolzon, S., Guerra, Eliana, Stella, M., Ferrara, F., Stipa, F., Stringhi, E., Celotti, A., Taglietti, L., Del Giudice, R., Talarico, C. A., Ruggiero, Miriam, Tirone, G., Romario, U. F., Petz, W., Caracino, V., Rossetti, V., Verza, L. A., Vescovi, L., Marini, M., Vettoretto, N., Botteri, E., Vincenti, L., Giannandrea, G., Viora, T., Maganuco, L., Veronesi, P., Zani, B., Zanus, G., Brizzolari, M., Zanzi, F., Guariniello, A., Zappa, M. A., Galfrascoli, E., Zonta, S., Oragano, L., Zuliani, W., Chiari, D., Podda M. (ORCID:0000-0002-2779-8417), Sartori A., Alfieri S. (ORCID:0000-0002-0404-724X), Rosa F. (ORCID:0000-0002-7280-8354), Parisi A., Belli A., Izzo F., Brunetti M., Bianco F., Perna F., Perrone G., Cesari M., Chiara O., Biral M., Marino G., Fabozzi M., Auricchio A., Milone M., Giuliani A. (ORCID:0000-0002-0773-2162), Di Natale G., Brisinda G. (ORCID:0000-0001-8820-9471), Gallo G., Greco V. (ORCID:0000-0003-4521-0020), Lombardi R., Asti E., Manca G., Guerrieri M. (ORCID:0000-0001-5782-6936), Casiraghi S., Petracca M., Musella M., Oldani A., Mottola A., Santoro R., Sganga G. (ORCID:0000-0001-5079-0395), De Rosa C., Guerra E., Ruggiero M., Bracale, U., Podda, Maria Vittoria, Castiglioni, S., Peltrini, R., Sartori, Alessandra, Arezzo, A., Corcione, F., Agresta, F., Antonucci, A., Zanframundo, C., Cavallo, F., Mazzarolo, G., Agrusa, A., Di Buono, G., Aldrighetti, L., Fiorentini, G., Lucianetti, A., Magnone, S., Alfieri, Sergio, Rosa, Fausto, Altomare, D. F., Picciariello, A., Parisi, Carmelo Maria Antonio, Di Cintio, A., Amisano, M. F., Cravero, F., Ammendola, M., Ammerata, G., Anastasi, A., Canonico, G., Gattolin, A., Travaglio, E., De Palma, M., Angelini, P., Galante, F., Benevento, A., Rausei, S., Serao, A., Abbatini, F., Annecchiarico, M., Varricchio, A., Annessi, V., Tumiati, D., Annicchiarico, A., Mirabella, A., Marino, M. V., Spinelli, A., Braun, A., Santi, H. T., Romano, L., Antoniutti, M., Armellino, M. F., Argenio, G., Verzelli, A., Budassi, A., Baiocchi, G., Alfano, M. S., Balani, A., Barone, M., Baldazzi, G., Cassini, D., Canger, R. C. B., Zabbialini, G., Belli, Andrea, Izzo, Filippo, Bertolino, F., Brunetti, Maria Mercede, Bianco, Flaviana, Cappiello, A., Boccia, L., Boffi, B., Perna, Francesco, Bonilauri, S., Frazzetta, G., Bordoni, P., Fleres, F., Borghi, F., Giraudo, G., Bottino, V., Canfora, A., Piccoli, F. B., Calligaris, L., Nipote, B., Nasti, A. G., Bufalari, A., Bettarini, F., Buononato, M., Greco, M., Calo, P. G., Medas, F., Cardamone, E., Castaldo, P., Carlini, M., Spoletini, D., De Nisco, C., Pulighe, F., Feo, C. V., Fabbri, N., Antropoli, C., Foroni, F., Carnazza, M., Ragazzi, S., Cassinotti, E., Boni, L., Catena, F., Giuffrida, M., Perrone, Giuseppe, Ccotsoglou, C., Granieri, S., Ceccarelli, G., Bugiantella, W., Cedolini, C., Seriau, L., Cesari, Matteo, Contine, A., Chiara, Osvaldo, Cimbanassi, S., Cocozza, E., Berselli, M., Fantini, C., Costi, R., Casali, L., Morini, A., Crafa, F., Vanela, S., Curro, G., Orsini, V., Da Lio, C., Biral, Maria Francesca, Danelli, P., Guerci, C., Scala, D., Marino, Giuseppe, De Carlis, L., Lauterio, A., De Giorgi, D., Sciannamea, G., De Manzini, N., Losurdo, P., Sangiuliano, N., Degiuli, M., Caterina, F., Del Rio, P., Bonati, E., Di Lernia, S., Ardizzone, M. V. R., Di Saverio, S., Franchi, C., Di Venere, B., Miglio, R., Cuccurullo, D., Sagnelli, C., Docimo, L., Tolone, S., Longoni, M., Faillace, G., Rondelli, F., Pennella, F. P., Colucci, V., Carfora, T., Muttillo, I. A., Picardi, B., Stefano, R., Campagnacci, R., Maurizi, A., Tricarico, F., Montagna, M., Amedeo, E., Scollica, M. C., Lauro, E., Laterza, E., Molinari, E., Berta, G., Bono, D., Fabozzi, Simone Michele, Romano, M., Facci, E., Parini, D., Farfaglia, R., Arizzi, V., Farsi, M., Miranda, E., Fei, L., Flavio, G., Pirozzi, F., Sciuto, A., Ferrero, A., Palisi, M., Filauro, M., Barberis, A., Azzinnaro, A., Fiscon, V., Vigna, S., D'Ambra, M., Pontecorvi, E., Anania, G., Bombardini, C., Galizia, G., Auricchio, Anna Maria, Cardella, F., Genna, M., Gentilli, S., Herald, N., Castagnoli, G., Bartoli, A., Gianotti, L., Garancini, M., Bellanova, G., Palazzo, P., De Palma, G., Milone, Maria, Ferrari, G., Magistro, C., Giuliani, Antonio, Di Natale, Maria Grazia, Brisinda, Giuseppe, Cavallaro, G., Sammarco, G., Gallo, Giuseppe, Goletti, O., Macchini, D., Greco, Viviana, Amoroso, V., Guercioni, G., Benedetti, M., Guzzo, G., Pata, F., Scandroglio, I., Roscio, F., Jovine, E., Lombardi, Roberto, La Rocca, F., Di Capua, F., Lanci, C., Leli, R., Borasi, A., Lepiane, P., Balla, A., Liberatore, E., Morelli, L., Di Franco, G., Lucchi, A., Vittori, L., Bonavina, L., Asti, Emilio Fabrizio, Maggioni, D., Martino, G., Manca, Gavina, Delvecchio, A., Tedesco, M., Gambardella, D., Marafioti, S., De Marco, M. L., Guicciardi, M. A., Motta, M., Calgaro, M., Adamo, V., Guerrieri, Maria Chiara, Coletta, P., Ortenzi, M., Martines, G., Lantone, G., Martinotti, M., Fassardi, G., Castriconi, M., Squillante, S., De Luca, M., Pavanello, M., Di Marco, C., Ronconi, M., Casiraghi, Maria Stella, Mazzaferro, V., Battiston, C., Perrotta, M., Ripa, C., Giancarlo, M., Panizzo, V., Millo, P., Contul, R. B., Ferraro, V., Molino, C., Crolla, E., Moretto, G., Bacchion, M., Morino, M., Allaix, M. E., Motterlini, E., Petracca, Martina, Muratore, A., Musella, Martina, Vitiello, A., Nardo, B., Crocco, V., Navarra, G., Lazzara, S., Navarra, G. G., Cuoghi, M., Olmi, S., Oldani, Alberto, Uccelli, M., Opocher, E., Giovenzana, M., De Paolis, P., Santarelli, M., Delrio, P., Carbone, F., Bianchi, P. P. G., Formisano, Capelli, P., Baldini, E., Festa, P., Mottola, Armando, Merola, G., Perrotta, N., Celiento, M., Personnettaz, E., Muzio, S., Petitti, T., Melchiorre, A., Piccoli, M., Pecchini, F., Frontali, A., Maffioli, A., Maida, P., Tammaro, P., Pignata, G., Andreuccetti, J., Pilone, V., Renzulli, M., Pintaldi, S., Ceretti, A. P., Mariani, N. M., Pisanu, A., Polastri, R., Maiello, F., Porcu, A., Perra, T., Mucilli, F., Troisi, R., Montalti, R., Scognamillo, F., Delogu, D., Galleano, R., Malerba, M., Salfi, R., Pisano, M., Sechi, R., Cillara, N., Ramuscello, S., De Leo, E., Restini, E., Tumolo, R., Cianci, P., Capuzzolo, S., Rizzo, M., Recordare, A., Santoro, Roberto, Amodio, P. M., Rocca, A., Cecere, G., Romito, R., Portigliotti, L., Rosati, R., Elmore, U., Russello, D., Latteri, S., Costarella, S. M., Massa, S., Capasso, L., Santangelo, M., Sodo, M., Sarro, G., Rivolta, U., Scabini, S., Pertile, D., Selvaggi, F., Rossi, S., Pellino, G., Sganga, Gabriele, Fransvea, P., Testa, S., De Rosa, Maria Cristina, Siquini, W., Trana, C., Solej, M., Bolzon, S., Guerra, Eliana, Stella, M., Ferrara, F., Stipa, F., Stringhi, E., Celotti, A., Taglietti, L., Del Giudice, R., Talarico, C. A., Ruggiero, Miriam, Tirone, G., Romario, U. F., Petz, W., Caracino, V., Rossetti, V., Verza, L. A., Vescovi, L., Marini, M., Vettoretto, N., Botteri, E., Vincenti, L., Giannandrea, G., Viora, T., Maganuco, L., Veronesi, P., Zani, B., Zanus, G., Brizzolari, M., Zanzi, F., Guariniello, A., Zappa, M. A., Galfrascoli, E., Zonta, S., Oragano, L., Zuliani, W., Chiari, D., Podda M. (ORCID:0000-0002-2779-8417), Sartori A., Alfieri S. (ORCID:0000-0002-0404-724X), Rosa F. (ORCID:0000-0002-7280-8354), Parisi A., Belli A., Izzo F., Brunetti M., Bianco F., Perna F., Perrone G., Cesari M., Chiara O., Biral M., Marino G., Fabozzi M., Auricchio A., Milone M., Giuliani A. (ORCID:0000-0002-0773-2162), Di Natale G., Brisinda G. (ORCID:0000-0001-8820-9471), Gallo G., Greco V. (ORCID:0000-0003-4521-0020), Lombardi R., Asti E., Manca G., Guerrieri M. (ORCID:0000-0001-5782-6936), Casiraghi S., Petracca M., Musella M., Oldani A., Mottola A., Santoro R., Sganga G. (ORCID:0000-0001-5079-0395), De Rosa C., Guerra E., and Ruggiero M.

Abstract

Background: The spread of the SARS-CoV2 virus, which causes COVID-19 disease, profoundly impacted the surgical community. Recommendations have been published to manage patients needing surgery during the COVID-19 pandemic. This survey, under the aegis of the Italian Society of Endoscopic Surgery, aims to analyze how Italian surgeons have changed their practice during the pandemic. Methods: The authors designed an online survey that was circulated for completion to the Italian departments of general surgery registered in the Italian Ministry of Health database in December 2020. Questions were divided into three sections: hospital organization, screening policies, and safety profile of the surgical operation. The investigation periods were divided into the Italian pandemic phases I (March–May 2020), II (June–September 2020), and III (October–December 2020). Results: Of 447 invited departments, 226 answered the survey. Most hospitals were treating both COVID-19-positive and -negative patients. The reduction in effective beds dedicated to surgical activity was significant, affecting 59% of the responding units. 12.4% of the respondents in phase I, 2.6% in phase II, and 7.7% in phase III reported that their surgical unit had been closed. 51.4%, 23.5%, and 47.8% of the respondents had at least one colleague reassigned to non-surgical COVID-19 activities during the three phases. There has been a reduction in elective (> 200 procedures: 2.1%, 20.6% and 9.9% in the three phases, respectively) and emergency (< 20 procedures: 43.3%, 27.1%, 36.5% in the three phases, respectively) surgical activity. The use of laparoscopy also had a setback in phase I (25.8% performed less than 20% of elective procedures through laparoscopy). 60.6% of the respondents used a smoke evacuation device during laparoscopy in phase I, 61.6% in phase II, and 64.2% in phase III. Almost all responders (82.8% vs. 93.2% vs. 92.7%) in each analyzed period did not modify or reduce the use of high-energ

Published
2021

25. Metabolic control and complications in Italian people with diabetes treated with continuous subcutaneous insulin infusion

Author

Lepore, G, Bonfanti, R, Bozzetto, L, Di Blasi, V, Girelli, A, Grassi, G, Iafusco, D, Laviola, L, Rabbone, I, Schiaffini, R, Bruttomesso, D, Mammi, F, Bruzzese, M, Schettino, M, Nuzzo, M, Fresa, R, Lambiase, C, Zanfardino, A, Confetto, S, Annuzzi, G, Alderisio, A, Riccardi, G, Gentile, S, Marino, G, Guarino, G, Zucchini, S, Maltoni, G, Suprani, T, Graziani, V, Nizzoli, M, Acquati, S, Cavani, R, Romano, S, Michelini, M, Manicardi, E, Bonadonna, R, Dei Cas, A, Dall'Aglio, E, Papi, M, Riboni, S, Manicardi, V, Pugni, V, Lasagni, A, Street, M, Pagliani, U, Rossi, C, Assaloni, R, Brunato, B, Tortul, C, Zanette, G, Li Volsi, P, Zanatta, M, Tonutti, L, Agus, S, Pellegrini, M, Ceccano, P, Pozzilli, G, Anguissola, B, Buzzetti, R, Moretti C, C, Leto, G, Pozzilli, P, Manfrini, S, Maurizi, A, Leotta, S, Altomare, M, Abbruzzese, S, Carletti, S, Suraci, C, Filetti, S, Manca Bitti, M, Arcano, S, Cavallo, M, De Bernardinis, M, Pitocco, D, Caputo, S, Rizzi, A, Manto, A, Cappa, M, Benevento, D, Frontoni, S, Malandrucco, I, Morano, S, Filardi, T, Lauro, D, Marini, M, Castaldo, E, Sabato, D, Tuccinardi, F, Forte, E, Viterbori, P, Arnaldi, C, Minuto, N, D'Annunzio, G, Corsi, A, Rota, R, Scaranna, C, Trevisan, R, Valentini, U, Bonfadini, S, Zarra, E, Plebani, A, Prandi, E, Felappi, B, Rocca, A, Meneghini, E, Galli, P, Ruggeri, P, Carrai, E, Fugazza, L, Baggi, V, Conti, D, Bosi, E, Laurenzi, A, Caretto, A, Molinari, C, Orsi, E, Grancini, V, Resi, V, Favalli, V, Bonura, C, Rigamonti, A, Bonomo, M, Bertuzzi, F, Pintaudi, B, Disoteo, O, Perseghin, G, Perra, S, Chiovato, L, De Cata, P, Zerbini, F, Lovati, E, Laneri, M, Guerraggio, L, Bossi, A, De Mori, V, Galetta, M, Meloncelli, I, Aiello A, A, Di Vincenzo, S, Nuzzi, A, Fraticelli, E, Ansaldi, E, Battezzati, M, Lombardi, M, Balbo, M, Lera, R, Secco, A, De Donno, V, Cadario, F, Savastio, S, Ponzani, C, Aimaretti, G, Ignaccolo, G, Tinti, D, Cerutti, F, Bari, F, Giorgino, F, Piccinno, E, Zecchino, O, Cignarelli, M, Lamacchia, O, Picca, G, De Cosmo, S, Rauseo, A, Tomaselli, L, Tumminia, A, Egiziano, C, Scarpitta, A, Maggio, F, Cardella, F, Roppolo, R, Provenzano, V, Fleres, M, Scorsone, A, Scatena, A, Gregori, G, Lucchesi, S, Gadducci, F, Di Cianni, S, Pancani, S, Del Prato, S, Aragona, M, Crisci, I, Calianno, A, Fattor, B, Crazzolara, D, Reinstadler, P, Longhi, S, Incelli, G, Rauch, S, Romanelli, T, Orrasch, M, Cauvin, V, Franceschi, R, Lalli, C, Pianta, A, Marangoni, A, Arico, C, Marin, N, Nogara, N, Simioni, N, Filippi, A, Gidoni Guarneri, G, Contin, M, Decata, A, Bondesan, L, Confortin, L, Coracina, A, Lombardi, S, Costa Padova, S, Cipponeri, E, Scotton, R, Galasso, S, Boscari, F, Zanon, M, Vinci, C, Lisato, G, Gottardo, L, Bonora, E, Trombetta, M, Negri, C, Brangani, C, Maffeis, C, Sabbion, A, Marigliano, M, Lepore G., Bonfanti R., Bozzetto L., Di Blasi V., Girelli A., Grassi G., Iafusco D., Laviola L., Rabbone I., Schiaffini R., Bruttomesso D., Mammi F., Bruzzese M., Schettino M., Nuzzo M. G., Fresa R., Lambiase C., Zanfardino A., Confetto S., Annuzzi G., Alderisio A., Riccardi G., Gentile S., Marino G., Guarino G., Zucchini S., Maltoni G., Suprani T., Graziani V., Nizzoli M., Acquati S., Cavani R., Romano S., Michelini M., Manicardi E., Bonadonna R., Dei Cas A., Dall'aglio E., Papi M., Riboni S., Manicardi V., Pugni V., Lasagni A., Street M. E., Pagliani U., Rossi C., Assaloni R., Brunato B., Tortul C., Zanette G., Li Volsi P., Zanatta M., Tonutti L., Agus S., Pellegrini M. A., Ceccano P., Pozzilli G., Anguissola B., Buzzetti R., Moretti C C., Leto G., Pozzilli P., Manfrini S., Maurizi A. R., Leotta S., Altomare M., Abbruzzese S., Carletti S., Suraci C., Filetti S., Manca Bitti M. L., Arcano S., Cavallo M. G., De Bernardinis M., Pitocco D., Caputo S., Rizzi A., Manto A., Cappa M., Benevento D., Frontoni S., Malandrucco I., Morano S., Filardi T., Lauro D., Marini M. A., Castaldo E., Sabato D., Tuccinardi F., Forte E., Viterbori P., Arnaldi C., Minuto N., d'Annunzio G., Corsi A., Rota R., Scaranna C., Trevisan R., Valentini U., Bonfadini S., Zarra E., Plebani A., Prandi E., Felappi B., Rocca A., Meneghini E., Galli P., Ruggeri P., Carrai E., Fugazza L., Baggi V., Conti D., Bosi E., Laurenzi A., Caretto A., Molinari C., Orsi E., Grancini V., Resi V., Favalli V., Bonura C., Rigamonti A., Bonomo M., Bertuzzi F., Pintaudi B., Disoteo O., Perseghin G., Perra S., Chiovato L., De Cata P., Zerbini F., Lovati E., Laneri M., Guerraggio L., Bossi A. C., De Mori V., Galetta M., Meloncelli I., Aiello A A., Di Vincenzo S., Nuzzi A., Fraticelli E., Ansaldi E., Battezzati M., Lombardi M., Balbo M., Lera R., Secco A., De Donno V., Cadario F., Savastio S., Ponzani C., Aimaretti G., Ignaccolo G., Tinti D., Cerutti F., Bari F., Giorgino F., Piccinno E., Zecchino O., Cignarelli M., Lamacchia O., Picca G., De Cosmo S., Rauseo A., Tomaselli L., Tumminia A., Egiziano C., Scarpitta A. M., Maggio F., Cardella F., Roppolo R., Provenzano V., Fleres M., Scorsone A., Scatena A., Gregori G., Lucchesi S., Gadducci F., Di Cianni S., Pancani S., Del Prato S., Aragona M., Crisci I., Calianno A., Fattor B., Crazzolara D., Reinstadler P., Longhi S., Incelli G., Rauch S., Romanelli T., Orrasch M., Cauvin V., Franceschi R., Lalli C., Pianta A., Marangoni A., Arico C. N., Marin N., Nogara N., Simioni N., Filippi A., Gidoni Guarneri G. L., Contin M. L M. L., Decata A. P., Bondesan L., Confortin L., Coracina A., Lombardi S., Costa Padova S., Cipponeri E., Scotton R., Galasso S., Boscari F., Zanon M. S., Vinci C., Lisato G., Gottardo L., Bonora E., Trombetta M., Negri C., Brangani C., Maffeis C., Sabbion A., Marigliano M., Lepore, G, Bonfanti, R, Bozzetto, L, Di Blasi, V, Girelli, A, Grassi, G, Iafusco, D, Laviola, L, Rabbone, I, Schiaffini, R, Bruttomesso, D, Mammi, F, Bruzzese, M, Schettino, M, Nuzzo, M, Fresa, R, Lambiase, C, Zanfardino, A, Confetto, S, Annuzzi, G, Alderisio, A, Riccardi, G, Gentile, S, Marino, G, Guarino, G, Zucchini, S, Maltoni, G, Suprani, T, Graziani, V, Nizzoli, M, Acquati, S, Cavani, R, Romano, S, Michelini, M, Manicardi, E, Bonadonna, R, Dei Cas, A, Dall'Aglio, E, Papi, M, Riboni, S, Manicardi, V, Pugni, V, Lasagni, A, Street, M, Pagliani, U, Rossi, C, Assaloni, R, Brunato, B, Tortul, C, Zanette, G, Li Volsi, P, Zanatta, M, Tonutti, L, Agus, S, Pellegrini, M, Ceccano, P, Pozzilli, G, Anguissola, B, Buzzetti, R, Moretti C, C, Leto, G, Pozzilli, P, Manfrini, S, Maurizi, A, Leotta, S, Altomare, M, Abbruzzese, S, Carletti, S, Suraci, C, Filetti, S, Manca Bitti, M, Arcano, S, Cavallo, M, De Bernardinis, M, Pitocco, D, Caputo, S, Rizzi, A, Manto, A, Cappa, M, Benevento, D, Frontoni, S, Malandrucco, I, Morano, S, Filardi, T, Lauro, D, Marini, M, Castaldo, E, Sabato, D, Tuccinardi, F, Forte, E, Viterbori, P, Arnaldi, C, Minuto, N, D'Annunzio, G, Corsi, A, Rota, R, Scaranna, C, Trevisan, R, Valentini, U, Bonfadini, S, Zarra, E, Plebani, A, Prandi, E, Felappi, B, Rocca, A, Meneghini, E, Galli, P, Ruggeri, P, Carrai, E, Fugazza, L, Baggi, V, Conti, D, Bosi, E, Laurenzi, A, Caretto, A, Molinari, C, Orsi, E, Grancini, V, Resi, V, Favalli, V, Bonura, C, Rigamonti, A, Bonomo, M, Bertuzzi, F, Pintaudi, B, Disoteo, O, Perseghin, G, Perra, S, Chiovato, L, De Cata, P, Zerbini, F, Lovati, E, Laneri, M, Guerraggio, L, Bossi, A, De Mori, V, Galetta, M, Meloncelli, I, Aiello A, A, Di Vincenzo, S, Nuzzi, A, Fraticelli, E, Ansaldi, E, Battezzati, M, Lombardi, M, Balbo, M, Lera, R, Secco, A, De Donno, V, Cadario, F, Savastio, S, Ponzani, C, Aimaretti, G, Ignaccolo, G, Tinti, D, Cerutti, F, Bari, F, Giorgino, F, Piccinno, E, Zecchino, O, Cignarelli, M, Lamacchia, O, Picca, G, De Cosmo, S, Rauseo, A, Tomaselli, L, Tumminia, A, Egiziano, C, Scarpitta, A, Maggio, F, Cardella, F, Roppolo, R, Provenzano, V, Fleres, M, Scorsone, A, Scatena, A, Gregori, G, Lucchesi, S, Gadducci, F, Di Cianni, S, Pancani, S, Del Prato, S, Aragona, M, Crisci, I, Calianno, A, Fattor, B, Crazzolara, D, Reinstadler, P, Longhi, S, Incelli, G, Rauch, S, Romanelli, T, Orrasch, M, Cauvin, V, Franceschi, R, Lalli, C, Pianta, A, Marangoni, A, Arico, C, Marin, N, Nogara, N, Simioni, N, Filippi, A, Gidoni Guarneri, G, Contin, M, Decata, A, Bondesan, L, Confortin, L, Coracina, A, Lombardi, S, Costa Padova, S, Cipponeri, E, Scotton, R, Galasso, S, Boscari, F, Zanon, M, Vinci, C, Lisato, G, Gottardo, L, Bonora, E, Trombetta, M, Negri, C, Brangani, C, Maffeis, C, Sabbion, A, Marigliano, M, Lepore G., Bonfanti R., Bozzetto L., Di Blasi V., Girelli A., Grassi G., Iafusco D., Laviola L., Rabbone I., Schiaffini R., Bruttomesso D., Mammi F., Bruzzese M., Schettino M., Nuzzo M. G., Fresa R., Lambiase C., Zanfardino A., Confetto S., Annuzzi G., Alderisio A., Riccardi G., Gentile S., Marino G., Guarino G., Zucchini S., Maltoni G., Suprani T., Graziani V., Nizzoli M., Acquati S., Cavani R., Romano S., Michelini M., Manicardi E., Bonadonna R., Dei Cas A., Dall'aglio E., Papi M., Riboni S., Manicardi V., Pugni V., Lasagni A., Street M. E., Pagliani U., Rossi C., Assaloni R., Brunato B., Tortul C., Zanette G., Li Volsi P., Zanatta M., Tonutti L., Agus S., Pellegrini M. A., Ceccano P., Pozzilli G., Anguissola B., Buzzetti R., Moretti C C., Leto G., Pozzilli P., Manfrini S., Maurizi A. R., Leotta S., Altomare M., Abbruzzese S., Carletti S., Suraci C., Filetti S., Manca Bitti M. L., Arcano S., Cavallo M. G., De Bernardinis M., Pitocco D., Caputo S., Rizzi A., Manto A., Cappa M., Benevento D., Frontoni S., Malandrucco I., Morano S., Filardi T., Lauro D., Marini M. A., Castaldo E., Sabato D., Tuccinardi F., Forte E., Viterbori P., Arnaldi C., Minuto N., d'Annunzio G., Corsi A., Rota R., Scaranna C., Trevisan R., Valentini U., Bonfadini S., Zarra E., Plebani A., Prandi E., Felappi B., Rocca A., Meneghini E., Galli P., Ruggeri P., Carrai E., Fugazza L., Baggi V., Conti D., Bosi E., Laurenzi A., Caretto A., Molinari C., Orsi E., Grancini V., Resi V., Favalli V., Bonura C., Rigamonti A., Bonomo M., Bertuzzi F., Pintaudi B., Disoteo O., Perseghin G., Perra S., Chiovato L., De Cata P., Zerbini F., Lovati E., Laneri M., Guerraggio L., Bossi A. C., De Mori V., Galetta M., Meloncelli I., Aiello A A., Di Vincenzo S., Nuzzi A., Fraticelli E., Ansaldi E., Battezzati M., Lombardi M., Balbo M., Lera R., Secco A., De Donno V., Cadario F., Savastio S., Ponzani C., Aimaretti G., Ignaccolo G., Tinti D., Cerutti F., Bari F., Giorgino F., Piccinno E., Zecchino O., Cignarelli M., Lamacchia O., Picca G., De Cosmo S., Rauseo A., Tomaselli L., Tumminia A., Egiziano C., Scarpitta A. M., Maggio F., Cardella F., Roppolo R., Provenzano V., Fleres M., Scorsone A., Scatena A., Gregori G., Lucchesi S., Gadducci F., Di Cianni S., Pancani S., Del Prato S., Aragona M., Crisci I., Calianno A., Fattor B., Crazzolara D., Reinstadler P., Longhi S., Incelli G., Rauch S., Romanelli T., Orrasch M., Cauvin V., Franceschi R., Lalli C., Pianta A., Marangoni A., Arico C. N., Marin N., Nogara N., Simioni N., Filippi A., Gidoni Guarneri G. L., Contin M. L M. L., Decata A. P., Bondesan L., Confortin L., Coracina A., Lombardi S., Costa Padova S., Cipponeri E., Scotton R., Galasso S., Boscari F., Zanon M. S., Vinci C., Lisato G., Gottardo L., Bonora E., Trombetta M., Negri C., Brangani C., Maffeis C., Sabbion A., and Marigliano M.

Abstract

Background and aim: The objective of this cross-sectional study was to evaluate the degree of glycaemic control and the frequency of diabetic complications in Italian people with diabetes who were treated with continuous subcutaneous insulin infusion (CSII). Methods and results: Questionnaires investigating the organisation of diabetes care centres, individuals’ clinical and metabolic features and pump technology and its management were sent to adult and paediatric diabetes centres that use CSII for treatment in Italy. Information on standard clinical variables, demographic data and acute and chronic diabetic complications was derived from local clinical management systems. The sample consisted of 6623 people with diabetes, which was obtained from 93 centres. Of them, 98.8% had type 1 diabetes mellitus, 57.2% were female, 64% used a conventional insulin pump and 36% used a sensor-augmented insulin pump. The median glycated haemoglobin (HbA1c) level was 60 mmol/mol (7.6%). The HbA1c target (i.e. <58 mmol/mol for age <18 years and [removed]18 years) was achieved in 43.4% of paediatric and 23% of adult participants. Factors such as advanced pump functions, higher rate of sensor use, pregnancy in the year before the study and longer duration of diabetes were associated with lower HbA1c levels. The most common chronic complications occurring in diabetes were retinopathy, microalbuminuria and hypertension. In the year before the study, 5% of participants reported ≥1 episode of severe hypoglycaemic (SH) episodes (SH) and 2.6% reported ≥1 episode of ketoacidosis. Conclusions: Advanced personal skills and use of sensor-based pump are associated with better metabolic control outcomes in Italian people with diabetes who were treated with CSII. The reduction in SH episodes confirms the positive effect of CSII on hypoglycaemia. Clinical trial registration number: NCT 02620917 (ClinicalTrials.gov).

Published
2018

26. Advanced health information technologies to engage parents, clinicians, and community nutritionists in coordinating responsive parenting care: Descriptive case series of the women, infants, and children enhancements to early healthy lifestyles for baby (WEE Baby) care randomized controlled trial

Author

Kling, S.M.R. (Samantha M.R.), Harris, H.A. (Holly A.), Marini, M. (Michele), Cook, A. (Adam), Hess, L.B. (Lindsey B.), Lutcher, S. (Shawnee), Mowery, J. (Jacob), Bell, S. (Scott), Hassink, S. (Sandra), Hayward, S.B. (Shannon B.), Johnson, G. (Greg), Hosterman, J.F. (Jennifer Franceschelli), Paul, I.M. (Ian M.), Seiler, C. (Christopher), Sword, S. (Shirley), Savage, J.S. (Jennifer S.), Bailey-Davis, L. (Lisa), Kling, S.M.R. (Samantha M.R.), Harris, H.A. (Holly A.), Marini, M. (Michele), Cook, A. (Adam), Hess, L.B. (Lindsey B.), Lutcher, S. (Shawnee), Mowery, J. (Jacob), Bell, S. (Scott), Hassink, S. (Sandra), Hayward, S.B. (Shannon B.), Johnson, G. (Greg), Hosterman, J.F. (Jennifer Franceschelli), Paul, I.M. (Ian M.), Seiler, C. (Christopher), Sword, S. (Shirley), Savage, J.S. (Jennifer S.), and Bailey-Davis, L. (Lisa)

Abstract

Background: Socioeconomically disadvantaged newborns receive care from primary care providers (PCPs) and Women, Infants, and Children (WIC) nutritionists. However, care is not coordinated between these settings, which can result in conflicting messages. Stakeholders support an integrated approach that coordinates services between settings with care tailored to patient-centered needs. Objective: This analysis describes the usability of advanced health information technologies aiming to engage parents in self-reporting parenting practices, integrate data into electronic health records to inform and facilitate documentation of provided responsive parenting (RP) care, and share data between settings to create opportunities to coordinate care between PCPs and WIC nutritionists. Methods: Parents and newborns (dyads) who were eligible for WIC care and received pediatric care in a single health system were recruited and randomized to a RP intervention or control group. For the 6-month intervention, electronic systems were created to facilitate documentation, data sharing, and coordination of provided RP care. Prior to PCP visits, parents were prompted to respond to the Early Healthy Lifestyles (EHL) self-assessment tool to capture current RP practices. Responses were integrated into the electronic health record and shared with WIC. Documentation of RP care and an 80-character, free-text comment were shared between WIC and PCPs. A care coordination opportunity existed when the dyad attended a WIC visit and these data were available from the PCP, and vice versa. Care coordination was demonstrated when WIC or PCPs interacted with data and documented RP care provided at the visit. Results: Dyads (N=131) attended 459 PCP (3.5, SD 1.0 per dyad) and 296 WIC (2.3, SD 1.0 per dyad) visits. Parents completed the EHL tool prior to 53.2% (244/459) of PCP visits (1.9, SD 1.2 per dyad), PCPs documented provided RP care at 35.3% (162/459) of visits, and data were shared with WIC following

Published
2020
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27. Pengaruh terapi murottal terhadap denyut nadi dan pernafasan pada bayi dengan berat badan lahir rendah

Author

Universitas Aisyah Pringsewu, Mukhlis, Hamid, Marini, M, Universitas Aisyah Pringsewu, Mukhlis, Hamid, and Marini, M

Abstract

Penurunan Angka Kematian Ibu (AKI) dan Angka Kematian Bayi (AKB) di Indonesia masih jauh dari target yang harus dicapai. AKB baru lahir di Indonesia mencapai 35 per 1000 kelahiran hidup. Bayi dengan Berat Badan Lahir Rendah (BBLR) merupakan salah satu penyebab kematian pertama pada bayi baru lahir di Provinsi Lampung. Penelitian ini bertujuan untuk mengetahui pengaruh terapi murottal terhadap kestabilan denyut nadi dan pernafasan pada bayi dengan BBLR di Rumah Sakit Umum Daerah Kota Agung. Desain penelitian menggunakan quasi eksperiment dengan pretest-posttest without control group. Subjek penelitian sebanyak 12 bayi dengan BBLR. Tehnik sampling dengan menggunakan consecutive sampling. Kelompok eksperimen mendapatkan terapi murottal Surat Ar Rahman dengan durasi 60 menit selama 3 hari dengan menggunakan speaker active kekuatan bunyi 50-60 dB. Analisis data menggunakan uji statistik paired t-test. Hasil penelitian menunjukkan penurunan rerata denyut nadi sebelum dan setelah treatmen didapatkan mean 161,50 dan 151,60 dengan nilai p value 0,001 (p kurang dari 0,05). Penurunan rerata pernafasan sebelum dan setelah treatmen didapatkan mean 67,00 dan 58,50 dengan p value 0,001 (p kurang dari 0,05). Terapi murottal berpengaruh terhadap frekuensi denyut nadi dan pernafasan bayi dengan berat badan lahir rendah. Terapi murottal dapat digunakan sebagai alternatif treatmen didalam terapi keperawatan komplementer dalam memberikan asuhan keperawatan bayi di ruang perinatologi.

Published
2020

28. Pengaruh terapi murottal terhadap denyut nadi dan pernafasan pada bayi dengan berat badan lahir rendah

Author

Universitas Aisyah Pringsewu, Mukhlis, Hamid, Marini, M, Universitas Aisyah Pringsewu, Mukhlis, Hamid, and Marini, M

Abstract

Penurunan Angka Kematian Ibu (AKI) dan Angka Kematian Bayi (AKB) di Indonesia masih jauh dari target yang harus dicapai. AKB baru lahir di Indonesia mencapai 35 per 1000 kelahiran hidup. Bayi dengan Berat Badan Lahir Rendah (BBLR) merupakan salah satu penyebab kematian pertama pada bayi baru lahir di Provinsi Lampung. Penelitian ini bertujuan untuk mengetahui pengaruh terapi murottal terhadap kestabilan denyut nadi dan pernafasan pada bayi dengan BBLR di Rumah Sakit Umum Daerah Kota Agung. Desain penelitian menggunakan quasi eksperiment dengan pretest-posttest without control group. Subjek penelitian sebanyak 12 bayi dengan BBLR. Tehnik sampling dengan menggunakan consecutive sampling. Kelompok eksperimen mendapatkan terapi murottal Surat Ar Rahman dengan durasi 60 menit selama 3 hari dengan menggunakan speaker active kekuatan bunyi 50-60 dB. Analisis data menggunakan uji statistik paired t-test. Hasil penelitian menunjukkan penurunan rerata denyut nadi sebelum dan setelah treatmen didapatkan mean 161,50 dan 151,60 dengan nilai p value 0,001 (p kurang dari 0,05). Penurunan rerata pernafasan sebelum dan setelah treatmen didapatkan mean 67,00 dan 58,50 dengan p value 0,001 (p kurang dari 0,05). Terapi murottal berpengaruh terhadap frekuensi denyut nadi dan pernafasan bayi dengan berat badan lahir rendah. Terapi murottal dapat digunakan sebagai alternatif treatmen didalam terapi keperawatan komplementer dalam memberikan asuhan keperawatan bayi di ruang perinatologi.

Published
2020

29. Multiphoton Fabrication of Proteinaceous Nanocomposite Microstructures with Photothermal Activity in the Infrared

Author

Zeynali, A, Marini, M, Chirico, G, Bouzin, M, Borzenkov, M, Sironi, L, D'Alfonso, L, Pallavicini, P, Cassina, V, Mantegazza, F, Granucci, F, Marongiu, L, Polli, D, De la Cadena, A, Collini, M, Zeynali, Amirbahador, Marini, Mario, Chirico, Giuseppe, Bouzin, Margaux, Borzenkov, Mykola, Sironi, Laura, D'Alfonso, Laura, Pallavicini, Piersandro, Cassina, Valeria, Mantegazza, Francesco, Granucci, Francesca, Marongiu, Laura, Polli, Dario, De la Cadena, Alejandro, Collini, Maddalena, Zeynali, A, Marini, M, Chirico, G, Bouzin, M, Borzenkov, M, Sironi, L, D'Alfonso, L, Pallavicini, P, Cassina, V, Mantegazza, F, Granucci, F, Marongiu, L, Polli, D, De la Cadena, A, Collini, M, Zeynali, Amirbahador, Marini, Mario, Chirico, Giuseppe, Bouzin, Margaux, Borzenkov, Mykola, Sironi, Laura, D'Alfonso, Laura, Pallavicini, Piersandro, Cassina, Valeria, Mantegazza, Francesco, Granucci, Francesca, Marongiu, Laura, Polli, Dario, De la Cadena, Alejandro, and Collini, Maddalena

Abstract

Two‐photon laser writing is used here to fabricate 3D proteinaceous microstructures with photothermal functionality in the near‐infrared spectral region and tunable elasticity. The photo‐cross‐linking is initiated in bovine serum albumin (BSA) by rose bengal or methylene blue and the photo‐thermal effect arises from gold non‐spherically symmetric nanoparticles dispersed in the ink. Massive energy transfer of the plasmonic resonances of the gold nanoparticles to methylene blue prevents effective photo‐crosslinking of BSA. However, stable microstructures with photo‐thermal functionality can be fabricated in the rose bengal proteinaceous inks. On these microstructures, with a gold atom concentration as low as 1% w/w, a highly localized temperature increase can be quickly (≅1 s) reached and maintained under continuous wave laser irradiation at 800 nm. The photothermal efficiency under continuous wave laser irradiation depends on the thickness of the microstructure and can reach 12.2 ± 0.4 °C W−1 These proteinaceous microstructures represent therefore a promising platform for future applications in the fields like physical stimulation of cells for regenerative nanomedicine.

Published
2020

30. Levosimendan to facilitate weaning from cardiorespiratory support in critically ill patients: current evidence and future directions

Author

Sangalli, F, Bellani, G, Affronti, A, Volpi, F, Feri, M, Marini, M, Quacquarelli, A, Vitale, D, Guarracino, F, Sangalli, Fabio, Bellani, Giacomo, Affronti, Alessandro, Volpi, Francesca, Feri, Marco, Marini, Marco, Quacquarelli, Antonio, Vitale, Domenico, Guarracino, Fabio, Sangalli, F, Bellani, G, Affronti, A, Volpi, F, Feri, M, Marini, M, Quacquarelli, A, Vitale, D, Guarracino, F, Sangalli, Fabio, Bellani, Giacomo, Affronti, Alessandro, Volpi, Francesca, Feri, Marco, Marini, Marco, Quacquarelli, Antonio, Vitale, Domenico, and Guarracino, Fabio

Abstract

Appropriate weaning is of crucial importance for critically ill patients requiring respiratory support. However, a remarkable proportion of them are difficult to wean. Levosimendan is a positive inotropic agent characterized by vasodilatory properties, which is used for the treatment of acute decompensated heart failure or in patients needing inotropic treatment, including cardiogenic shock, septic shock, pulmonary hypertension and right ventricular dysfunction, needed for hemodynamic support in patients with diuretic resistance, and weaning either from ventilator or from extracorporeal membrane oxygenation. This position paper will discuss the use of levosimendan in facilitating weaning from cardiorespiratory support in critically ill patients, according to available evidence and the personal experience of a group of Italian Experts.

Published
2020

31. La Chiesa e l’esclusione dei diversi tra X e XIII secolo: gli stranieri, gli eretici, gli Ebrei e gli Arabi

Author

Aulisa I, P, Avellis L, Barcellona R, Bertelli G, Bianco R, Boesch Gajano S, Bouet P, Campione A, Camplani A, Canetti L, Carile A, Carletti C, Carnevale L, Colucci von Saucken P, Cioffari G, Clausi B, Colantuono B, Cozzo P, D'Angela C, Di Berardino A, Filoramo G, Forte A, Gazeau V, Gianotto C, Infante R, Juhel V, Lagioia A, Lassandro D, Lettieri D, Luisi A, Lettieri G, Lupieri E, Marini M, Milazzo V, Monaco Castagno A, Nazzaro A, Neveux F, Nigro G, Perbene L, Pesce M, Piacente L, Polara G, Prinzivalli E, Resta M, Rusconi R, Sardella T, Sergi G, Torre A, Vauchez A, Vian G, Vincent C, Zugravu N., Laghezza A., Andenna, Giancarlo, Andenna Giancarlo (ORCID:0000-0003-0003-7674), Aulisa I, P, Avellis L, Barcellona R, Bertelli G, Bianco R, Boesch Gajano S, Bouet P, Campione A, Camplani A, Canetti L, Carile A, Carletti C, Carnevale L, Colucci von Saucken P, Cioffari G, Clausi B, Colantuono B, Cozzo P, D'Angela C, Di Berardino A, Filoramo G, Forte A, Gazeau V, Gianotto C, Infante R, Juhel V, Lagioia A, Lassandro D, Lettieri D, Luisi A, Lettieri G, Lupieri E, Marini M, Milazzo V, Monaco Castagno A, Nazzaro A, Neveux F, Nigro G, Perbene L, Pesce M, Piacente L, Polara G, Prinzivalli E, Resta M, Rusconi R, Sardella T, Sergi G, Torre A, Vauchez A, Vian G, Vincent C, Zugravu N., Laghezza A., Andenna, Giancarlo, and Andenna Giancarlo (ORCID:0000-0003-0003-7674)

Abstract

Il monaco e il suo comportamento in età medievale: gestualità, preghiera, linguaggio corporeo e di parole. L'esclusione dei Diversi e la persecuzione degli Ebrei e la traduzione del Corano per ordine di Pietro il Venerabile. La polemica contro il mondo musulmano. La posizione contraria di Francesco di Assisi. Bonaventura e la lotta contro i musulmani.

Published
2020

32. The emergence of Exercise Addiction, Body Dysmorphic Disorder, and other image-related psychopathological correlates in fitness settings: A cross sectional study

Author

Corazza, O, Simonato, P, Demetrovics, Z, Mooney, R, van de Ven, K, Roman-Urrestarazu, A, Rácmolnár, L, De Luca, I, Cinosi, E, Santacroce, R, Marini, M, Wellsted, D, Sullivan, K, Bersani, G, Martinotti, G, Corazza, O, Simonato, P, Demetrovics, Z, Mooney, R, van de Ven, K, Roman-Urrestarazu, A, Rácmolnár, L, De Luca, I, Cinosi, E, Santacroce, R, Marini, M, Wellsted, D, Sullivan, K, Bersani, G, and Martinotti, G

Abstract

Introduction In a society that perpetuates the strive for a perfect appearance, a fit body has become synonymous with success, but simultaneously hard to achieve. This represents a fertile ground for the development of Exercise Addiction (EA) alongside other disorders, such as Body Dysmorphic Disorder (BDD). This study aims to explore the diffusion of EA in fitness settings in the United Kingdom, Italy, Netherlands, Hungary and the previously unexplored association with appearance anxiety, BDD, self-esteem and the use of fitness supplements. Methods A large cross-sectional sample (N = 1711) was surveyed in fitness settings using the Exercise Addiction Inventory (EAI), Appearance Anxiety Inventory (AAI) and Rosenberg’s Self Esteem Scale (RSE) in addition to questions surrounding the use of fitness supplements. Results Compulsive exercise, appearance anxiety and low self-esteem were present in this sample according to the psychometric measures used (EAI, AAI, RSE). 11.7% scored over the cut off for EA, with alarming peaks in the Netherlands (20.9%) and the United Kingdom (16.1%). 38.5% were found at risk of BDD, mainly female (47.2%). 39.8% used fitness enhancing supplements without medical consultation (95.5%). This cohort of supplement users scored higher in both EAI and AAI. The logistic regression model revealed a strong association between the consumption of sport products and the level of EA across the sample with an odds ratio (OR) of 3.03. Other co-variable factors among female were appearance anxiety (AAI; OR 1.59) and to a lesser extent self-esteem (RSE) (OR 1.08). Conclusions This study identified a high risk of EA, appearance anxiety and BDD amongst a cohort of gym users internationally. The previously-unexplored association between these disorders and the unsupervised use of a variety of fitness products, including illicit drugs, highlights the need for informed and integrated responses targeting such vulnerable individuals.

Published
2019

33. Minimal impact of lenvatinib (Lenvima®) on muscle mass in advanced hepatocellular carcinoma and implications for treatment duration. Two cases from the REFLECT study

Author

Rinninella, Emanuele, Cintoni, M., Raoul, P., Mele, Maria Cristina, De Gaetano, Anna Maria, Marini, Maria Giulia, Mora, V., Gasbarrini, Antonio, Rinninella E. (ORCID:0000-0002-9165-2367), Mele M. C. (ORCID:0000-0003-0153-5819), De Gaetano A. M. (ORCID:0000-0002-7493-9462), Marini M. G., Gasbarrini A. (ORCID:0000-0002-7278-4823), Rinninella, Emanuele, Cintoni, M., Raoul, P., Mele, Maria Cristina, De Gaetano, Anna Maria, Marini, Maria Giulia, Mora, V., Gasbarrini, Antonio, Rinninella E. (ORCID:0000-0002-9165-2367), Mele M. C. (ORCID:0000-0003-0153-5819), De Gaetano A. M. (ORCID:0000-0002-7493-9462), Marini M. G., and Gasbarrini A. (ORCID:0000-0002-7278-4823)

Abstract

– OBJECTIVE: Two case reports of advanced unresectable hepatocellular carcinoma (HCC) treated with lenvatinib (Lenvima®) are presented; the drug’s effect on muscle loss and duration of treatment are discussed. PATIENTS AND METHODS: Between November 2014 and December 2017, at the Fondazione Policlinico A. Gemelli IRCCS, Rome, Italy, two male patients with advanced HCC enrolled in the lenvatinib arm of the REFLECT trial received the drug over 24 cycles (almost 2 years). We reviewed the clinical charts from baseline, when lenvatinib was started, through 24 months of treatment. The changes in the skeletal mass area (SMA), as assessed by computed tomography (CT) at the third lumbar level (L3), between baseline and month 24 into treatment were recorded. RESULTS: Case 1: SMA decreased by 2.8 cm2 between baseline and month 24 (134 cm2 vs. 131.2 cm2), with a muscle loss of 2.13%. Case 2: SMA decreased by 13 cm2 between baseline and month 24 (133 cm2 vs. 120 cm2), with a muscle loss of 10.83%. CONCLUSIONS: The disease remained stable for over 2.5 years in both patients. A minimal loss of muscle mass was noted at 24 months of treatment. The minimum effect on muscle loss may be correlated with the positive clinical response and the drug’s low toxicity. Our findings may help to elucidate the effect of lenvatinib on muscle mass and inform the development of the targeted nutritional support for HCC patients.

Published
2019

34. Hyperthermic intraperitoneal chemotherapy (HIPEC) and neoadjuvant chemotherapy as prophylaxis of peritoneal carcinosis from advanced gastric cancer-effects on overall and disease free survival

Author

Coccolini, F, Celotti, A, Ceresoli, M, Montori, G, Marini, M, Catena, F, Ansaloni, L, Coccolini F., Celotti A., Ceresoli M., Montori G., Marini M., Catena F., Ansaloni L., Coccolini, F, Celotti, A, Ceresoli, M, Montori, G, Marini, M, Catena, F, Ansaloni, L, Coccolini F., Celotti A., Ceresoli M., Montori G., Marini M., Catena F., and Ansaloni L.

Abstract

Background: The possibility to enlarge criteria for intra-peritoneal chemotherapy (IPC) to all patients at high-risk to develop peritoneal carcinosis (i.e., with serosal invasion) is still discussed. Methods: Retrospective case-control study. Three-groups: advanced-gastric-cancer (AGC) (pT4) without proven carcinosis: prophylactic group (PG), those with PC: treatment group (TG), AGC (pT3-pT4) operated without hyperthermic intraperitoneal chemotherapy (HIPEC), surgery alone group (SG T3, SG T4). Results: Forty four patients. 26 (59.1%) were male. Sixteen (36%) patients underwent 16 HIPEC: 6 (38%) had AGC (pT4) without PC (PG), 10 (62%) had carcinosis (TG), 28 were operated without HIPEC (SG T3, SG T4). The mean disease free survival (DFS): TG: 7.7 months, SG T4: 21.6 months, SG T3: 27.7 months, PG: 34.5 months. DFS was significantly different for TG (P=0.03, P=0.021, P=0.013 respectively). The mean OS TG: 10 months, SG T4: 27.1 months, SG T3: 28.2 months, PG: 34.6 months. OS was significantly different for TG (P=0.04, P=0.04, P=0.045 respectively). Severe complication rate: TG: 60%, PG: 16.7%, SG T3: 7.7% and SG T4: 25% (P=0.035). Length-of-stay differs significantly (P=0.003); overall length-of-stay: 19.41 days [standard deviation (SD) ±15.03]; TG: 33.01 (SD ±23.08), PG: 20.17 (SD ±6.21), SG T3: 11.33 (SD ±3.22), SG T4: 15.36 (SD ±5.48). Conclusions: Prophylactic intraperitoneal chemotherapy associated to neoadjuvant chemotherapy increases the DFS and OS in patients with AGC without carcinosis. More data are needed in order to confirm these results.

Published
2016

35. Subcutaneous insulin infusion (CSII) in italy: The third national survey [La terapia insulinica sottocutanea continua (CSII) in Italia. Terza indagine nazionale]

Author

Bruttomesso, D, Laviola, L, Lepore, G, Bonfanti, R, Bozzetto, L, Corsi, A, Di Blasi, V, Girelli, A, Grassi, G, Iafusco, D, Rabbone, I, Schiaffini, R, Montani, V, Colleluori, P, Paciotti, V, Alfidi, P, Grosso, J, Tumini, S, Cipriano, P, Vitacolonna, E, Di Vieste, G, Minnucci, A, Antenucci, D, La Penna, G, Taraborrelli, M, Macerala, B, Citro, G, De Morelli, G, Gnasso, A, Irace, C, Citriniti, F, Lazzaro, N, Bruzzese, M, Mammi, F, De Berardinis, F, Santoro, E, Corigliano, G, Corigliano, M, Parillo, M, Schettino, M, Fresa, R, Annuzzi, G, Bassi, V, Santinelli, C, Buono, P, Mozzillo, E, Russo, V, De Feo, E, Esposito, K, Petrizzo, M, Foglia, A, Gatti, A, Gentile, S, Guarino, G, Zanfardino, A, Lambiase, C, Vitale, A, Zucchini, S, Maltoni, G, Forlani, G, Moscatiello, S, Suprani, T, Bensa, M, Tomasi, F, Monesi, M, Nizzoli, M, Acquati, S, Chierici, G, Milli, B, Iughetti, L, Predieri, B, Cavani, R, Romano, S, Manicardi, V, Michelini, M, Cimicchi, M, Ugolotti, D, Zavaroni, I, Dei Cas, A, Dall'Aglio, E, Papi, M, Tardio, S, Calderini, M, Riboni, S, D'Amato, L, Zavaroni, D, Gastaldi, L, Cirillo, A, Di Bartolo, P, Pellicano, F, Di Secli, C, Amarri, S, Lasagni, A, Marsciani, A, Pedini, A, Pagliani, U, Rossi, C, Tortul, C, Brunato, B, Assaloni, R, Zanette, G, Livolsi, P, Petrucco, A, Tercelj, K, Manca, E, Candido, R, Tommasi, E, Tornese, G, Faleschini, E, Tonutti, L, Agus, S, Zanatta, M, Rosolen, A, Comici, A, Falasca, P, Graziano, F, Misischi, I, Forte, E, Palmacci, C, Tuccinardi, F, Ricciardi, G, Di Masa, P, Ragonese, M, Cipolloni, L, Buzzetti, R, Moretti, C, Leto, G, Crino, A, Bocchini, S, Pozzilli, P, Maurizi, A, Di Perna, P, Giuliano, M, Frontoni, S, Malandrucco, I, Pitocco, D, Scalpone, R, Toscanella, F, Cappa, M, Ventura, C, Bonato, V, De Bernardinis, M, Cavallo, M, Leonetti, F, Morano, S, Mandosi, E, Cicconetti, E, Ciampittiello, G, Marini, M, Sabato, D, Lauro, D, Napoli, A, Giraudo, F, Toscano, V, Pugliese, G, Massimiani, F, Fava, D, Gargiulo, P, Mecca, N, Tubili, C, Nardone, M, Morviducci, L, Manca-Bitti, M, Arcano, S, Leotta, S, Suraci, C, Chiaramonte, F, Visalli, N, Strollo, F, Arnaldi, C, Tosini, D, Ponzani, P, Patrone, M, Guido, R, Aglialoro, A, Ghisoni, G, Fabbri, F, Bordone, C, Maggi, D, Cordera, R, Minuto, N, Rotondo, E, Speranza, D, Siri, M, Carro, S, Zappa, A, Parmigiani, S, Nieri, S, Briatore, L, Calvo, G, Querci, F, Trevisan, R, Bonfadini, S, Prandi, E, Felappi, B, Locatelli, F, Fuso, V, Rocca, A, Meneghini, E, Massafra, C, Terni, T, Elli, P, Ruggeri, P, Carrai, E, Musacchio, N, Marelli, G, Vilei, V, Richini, D, Inversini, C, Franzetti, I, Bonacina, M, Ciucci, A, Sciangula, L, Duratorre, E, Bonomo, M, Bertuzzi, F, Chebat, E, Muratori, M, Scaramuzza, A, Zuccotti, G, Bollati, P, Colapinto, P, Orsi, E, Palmieri, E, Laurenzi, A, Molinari, C, Frontino, G, Veronelli, A, Zecchini, B, Bianchi, A, Torchio, G, Lovati, E, Ghilardi, G, Dagani, R, Berra, C, Fochesato, E, Pissarelli, A, Bucciarelli, L, Bulgheroni, M, Guerraggio, L, Zonca, S, Bossi, A, Berzi, D, Mangone, I, Cazzaniga, E, Rabini, R, Boemi, M, Faloia, E, Boscaro, M, Sternari, G, Iannilli, A, Cherubini, V, Tinti, G, Manfrini, S, Tesei, A, Maolo, G, Galetta, M, Vespasiani, G, Busciantella Ricci, N, Cartechini, M, Aiello, A, Di Vincenzo, S, Vitale, C, Di Caro, P, Lera, R, Secco, A, Lesina, A, Romeo, F, Origlia, C, Giorda, C, Chiambretti, A, Fornengo, R, De Donno, V, Gallarotti, F, Manti, R, Marafetti, L, Cadario, F, Savastio, S, Barbieri, P, Massucco, P, Ali, A, Gottero, C, Degiovanni, M, Bertaina, S, Maghenzani, G, Tinti, D, Fontana, F, Giorgino, F, Stefanelli, G, Cavallo, L, Zecchino, C, Piccinno, E, Ortolani, F, Gallo, F, Moramarco, F, Marino, A, Sparasci, G, Mileti, G, Lamacchia, O, Picca, G, Coccioli, M, Micale, F, Serra, R, Romano, I, Savino, T, Giovanni, S, De Cosmo, S, Rauseo, A, Delvecchio, M, Lapolla, R, Braione, A, Papagno, G, Baroni, M, Melis, M, Cossu, E, Songini, M, Cambuli, V, Lo Presti, D, Timpanaro, T, Chiavetta, A, Garofalo, M, Tommaselli, L, Tumminia, A, Scarpitta, A, Di Benedetto, A, Giunta, L, Lombardo, F, Salzano, G, Cardella, F, Roppolo, R, Provenzano, V, Fleres, M, Migliorini, S, De Luca, A, Leopardi, A, Beltrami, C, Toni, S, Guasti, G, Lenzi, L, Lamanna, C, Mannucci, E, Lucchesi, S, Di Cianni, G, Aragona, M, Del Prato, S, Fattor, B, Eisath, J, Pasquino, B, Reinstadler, P, Kaufmann, P, Incelli, G, Rauch, S, Romanelli, T, Cauvin, V, Franceschi, R, Ospedale, S, Soldani, C, Scattoni, R, Norgiolini, R, Celleno, R, Torlone, E, Bolli, G, Lalli, C, Scarponi, M, Bobbio, A, Bechaz, M, Pianta, A, Marangoni, A, Arico, C, Alagona, C, Confortin, L, Rossi, E, Boscolo, B, Nogara, A, Bettio, M, Frison, V, Guidoni, G, Fongher, C, Contin, M, Cosma, A, Vianello, S, Bondesan, L, Morea, A, Volpi, A, Coracina, A, Panebianco, G, Lombardi, S, Costa, S, Cipponeri, E, Vedovato, M, Scotton, R, Monciotti, C, Galderisi, A, Dalfra, M, Lapolla, A, Portogruaro, S, Zanon, M, Lisato, G, Mollo, F, Calcaterra, F, Miola, M, Paccagnella, A, Sambataro, M, Moro, E, Trombetta, M, Negri, C, Sabbion, A, Maffeis, C, Strazzabosco, M, Mesturino, C, Mingardi, R, Bruttomesso D., Laviola L., Lepore G., Bonfanti R., Bozzetto L., Corsi A., Di Blasi V., Girelli A., Grassi G., Iafusco D., Rabbone I., Schiaffini R., Montani V., Colleluori P., Paciotti V., Alfidi P., Grosso J., Tumini S., Cipriano P., Vitacolonna E., Di Vieste G., Minnucci A., Antenucci D., La Penna G., Taraborrelli M., Macerala B., Citro G., De Morelli G., Gnasso A., Irace C., Citriniti F., Lazzaro N., Bruzzese M., Mammi F., De Berardinis F., Santoro E., Corigliano G., Corigliano M., Parillo M., Schettino M., Fresa R., Annuzzi G., Bassi V., Santinelli C., Buono P., Mozzillo E., Russo V., De Feo E., Esposito K., Petrizzo M., Foglia A., Gatti A., Gentile S., Guarino G., Zanfardino A., Lambiase C., Vitale A., Zucchini S., Maltoni G., Forlani G., Moscatiello S., Suprani T., Bensa M., Tomasi F., Monesi M., Nizzoli M., Acquati S., Chierici G., Milli B., Iughetti L., Predieri B., Cavani R., Romano S., Manicardi V., Michelini M., Cimicchi M. C., Ugolotti D., Zavaroni I., Dei Cas A., Dall'Aglio E., Papi M., Tardio S. M., Calderini M. C., Riboni S., D'Amato L., Zavaroni D., Gastaldi L., Cirillo A., Di Bartolo P., Pellicano F., Di Secli C., Amarri S., Lasagni A., Marsciani A., Pedini A., Pagliani U., Rossi C., Tortul C., Brunato B., Assaloni R., Zanette G., Livolsi P., Petrucco A., Tercelj K., Manca E., Candido R., Tommasi E., Tornese G., Faleschini E., Tonutti L., Agus S., Zanatta M., Rosolen A., Comici A., Falasca P., Graziano F. M., Misischi I., Forte E., Palmacci C., Tuccinardi F., Ricciardi G. P., Di Masa P., Ragonese M., Cipolloni L., Buzzetti R., Moretti C., Leto G., Crino A., Bocchini S., Pozzilli P., Maurizi A. R., Di Perna P., Giuliano M., Frontoni S., Malandrucco I., Pitocco D., Scalpone R., Toscanella F., Cappa M., Ventura C., Bonato V., De Bernardinis M., Cavallo M. G., Leonetti F., Morano S., Mandosi E., Cicconetti E., Ciampittiello G., Marini M. A., Sabato D., Lauro D., Napoli A., Giraudo F., Toscano V., Pugliese G., Massimiani F., Fava D., Gargiulo P., Mecca N., Tubili C., Nardone M. R., Morviducci L., Manca-Bitti M. L., Arcano S., Leotta S., Suraci C., Chiaramonte F., Visalli N., Strollo F., Arnaldi C., Tosini D., Ponzani P., Patrone M., Guido R., Aglialoro A., Ghisoni G., Fabbri F., Bordone C., Maggi D., Cordera R., Minuto N., Rotondo E., Speranza D., Siri M., Carro S., Zappa A., Parmigiani S., Nieri S., Briatore L., Calvo G., Querci F., Trevisan R., Bonfadini S., Prandi E., Felappi B., Locatelli F., Fuso V., Rocca A., Meneghini E., Massafra C., Terni T., Elli P., Ruggeri P., Carrai E., Musacchio N., Marelli G., Vilei V., Richini D., Inversini C., Franzetti I., Bonacina M., Ciucci A., Sciangula L., Duratorre E., Bonomo M., Bertuzzi F., Chebat E., Muratori M., Scaramuzza A., Zuccotti G. V., Bollati P. M., Colapinto P., Orsi E., Palmieri E., Laurenzi A., Molinari C., Frontino G., Veronelli A., Zecchini B., Bianchi A., Torchio G., Lovati E., Ghilardi G., Dagani R., Berra C., Fochesato E., Pissarelli A., Bucciarelli L., Bulgheroni M., Guerraggio L., Zonca S., Bossi A. C., Berzi D., Mangone I., Cazzaniga E., Rabini R. A., Boemi M., Faloia E., Boscaro M., Sternari G., Iannilli A., Cherubini V., Tinti G., Manfrini S., Tesei A. M., Maolo G., Galetta M., Vespasiani G., Busciantella Ricci N., Cartechini M. G., Aiello A., Di Vincenzo S., Vitale C., Di Caro P., Lera R., Secco A., Lesina A., Romeo F., Origlia C., Giorda C., Chiambretti A. M., Fornengo R., De Donno V., Gallarotti F., Manti R., Marafetti L., Cadario F., Savastio S., Barbieri P., Massucco P., Ali A., Gottero C., Degiovanni M., Bertaina S., Maghenzani G., Tinti D., Fontana F., Giorgino F., Stefanelli G., Cavallo L., Zecchino C., Piccinno E., Ortolani F., Gallo F., Moramarco F., Marino A., Sparasci G., Mileti G., Lamacchia O., Picca G., Coccioli M. S., Micale F., Serra R., Romano I., Savino T., Giovanni S., De Cosmo S., Rauseo A., Delvecchio M., Lapolla R., Braione A. F., Papagno G., Baroni M., Melis M., Cossu E., Songini M., Cambuli V. M., Lo Presti D., Timpanaro T. A., Chiavetta A., Garofalo M. R., Tommaselli L., Tumminia A., Scarpitta A. M., Di Benedetto A., Giunta L., Lombardo F., Salzano G., Cardella F., Roppolo R., Provenzano V., Fleres M., Migliorini S., De Luca A., Leopardi A., Beltrami C., Toni S., Guasti G., Lenzi L., Lamanna C., Mannucci E., Lucchesi S., Di Cianni G., Aragona M., Del Prato S., Fattor B., Eisath J., Pasquino B., Reinstadler P., Kaufmann P., Incelli G., Rauch S., Romanelli T., Cauvin V., Franceschi R., Ospedale S. C., Soldani C., Scattoni R., Norgiolini R., Celleno R., Torlone E., Bolli G. B., Lalli C., Scarponi M., Bobbio A., Bechaz M., Pianta A., Marangoni A., Arico C. N., Alagona C., Confortin L., Rossi E., Boscolo B. A., Nogara A., Bettio M., Frison V., Guidoni G. L., Fongher C., Contin M. L., Cosma A., Vianello S., Bondesan L., Morea A., Volpi A., Coracina A., Panebianco G., Lombardi S., Costa S., Cipponeri E., Vedovato M., Scotton R., Monciotti C. M., Galderisi A., Dalfra M. G., Lapolla A., Portogruaro S., Zanon M., Lisato G., Mollo F., Calcaterra F., Miola M., Paccagnella A., Sambataro M., Moro E., Trombetta M., Negri C., Sabbion A., Maffeis C., Strazzabosco M., Mesturino C. A., Mingardi R., Bruttomesso, D, Laviola, L, Lepore, G, Bonfanti, R, Bozzetto, L, Corsi, A, Di Blasi, V, Girelli, A, Grassi, G, Iafusco, D, Rabbone, I, Schiaffini, R, Montani, V, Colleluori, P, Paciotti, V, Alfidi, P, Grosso, J, Tumini, S, Cipriano, P, Vitacolonna, E, Di Vieste, G, Minnucci, A, Antenucci, D, La Penna, G, Taraborrelli, M, Macerala, B, Citro, G, De Morelli, G, Gnasso, A, Irace, C, Citriniti, F, Lazzaro, N, Bruzzese, M, Mammi, F, De Berardinis, F, Santoro, E, Corigliano, G, Corigliano, M, Parillo, M, Schettino, M, Fresa, R, Annuzzi, G, Bassi, V, Santinelli, C, Buono, P, Mozzillo, E, Russo, V, De Feo, E, Esposito, K, Petrizzo, M, Foglia, A, Gatti, A, Gentile, S, Guarino, G, Zanfardino, A, Lambiase, C, Vitale, A, Zucchini, S, Maltoni, G, Forlani, G, Moscatiello, S, Suprani, T, Bensa, M, Tomasi, F, Monesi, M, Nizzoli, M, Acquati, S, Chierici, G, Milli, B, Iughetti, L, Predieri, B, Cavani, R, Romano, S, Manicardi, V, Michelini, M, Cimicchi, M, Ugolotti, D, Zavaroni, I, Dei 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S, Bossi, A, Berzi, D, Mangone, I, Cazzaniga, E, Rabini, R, Boemi, M, Faloia, E, Boscaro, M, Sternari, G, Iannilli, A, Cherubini, V, Tinti, G, Manfrini, S, Tesei, A, Maolo, G, Galetta, M, Vespasiani, G, Busciantella Ricci, N, Cartechini, M, Aiello, A, Di Vincenzo, S, Vitale, C, Di Caro, P, Lera, R, Secco, A, Lesina, A, Romeo, F, Origlia, C, Giorda, C, Chiambretti, A, Fornengo, R, De Donno, V, Gallarotti, F, Manti, R, Marafetti, L, Cadario, F, Savastio, S, Barbieri, P, Massucco, P, Ali, A, Gottero, C, Degiovanni, M, Bertaina, S, Maghenzani, G, Tinti, D, Fontana, F, Giorgino, F, Stefanelli, G, Cavallo, L, Zecchino, C, Piccinno, E, Ortolani, F, Gallo, F, Moramarco, F, Marino, A, Sparasci, G, Mileti, G, Lamacchia, O, Picca, G, Coccioli, M, Micale, F, Serra, R, Romano, I, Savino, T, Giovanni, S, De Cosmo, S, Rauseo, A, Delvecchio, M, Lapolla, R, Braione, A, Papagno, G, Baroni, M, Melis, M, Cossu, E, Songini, M, Cambuli, V, Lo Presti, D, Timpanaro, T, Chiavetta, A, Garofalo, M, Tommaselli, L, Tumminia, A, Scarpitta, A, Di Benedetto, A, Giunta, L, Lombardo, F, Salzano, G, Cardella, F, Roppolo, R, Provenzano, V, Fleres, M, Migliorini, S, De Luca, A, Leopardi, A, Beltrami, C, Toni, S, Guasti, G, Lenzi, L, Lamanna, C, Mannucci, E, Lucchesi, S, Di Cianni, G, Aragona, M, Del Prato, S, Fattor, B, Eisath, J, Pasquino, B, Reinstadler, P, Kaufmann, P, Incelli, G, Rauch, S, Romanelli, T, Cauvin, V, Franceschi, R, Ospedale, S, Soldani, C, Scattoni, R, Norgiolini, R, Celleno, R, Torlone, E, Bolli, G, Lalli, C, Scarponi, M, Bobbio, A, Bechaz, M, Pianta, A, Marangoni, A, Arico, C, Alagona, C, Confortin, L, Rossi, E, Boscolo, B, Nogara, A, Bettio, M, Frison, V, Guidoni, G, Fongher, C, Contin, M, Cosma, A, Vianello, S, Bondesan, L, Morea, A, Volpi, A, Coracina, A, Panebianco, G, Lombardi, S, Costa, S, Cipponeri, E, Vedovato, M, Scotton, R, Monciotti, C, Galderisi, A, Dalfra, M, Lapolla, A, Portogruaro, S, Zanon, M, Lisato, G, Mollo, F, Calcaterra, F, Miola, M, Paccagnella, A, Sambataro, M, Moro, E, Trombetta, M, Negri, C, Sabbion, A, Maffeis, C, Strazzabosco, M, Mesturino, C, Mingardi, R, Bruttomesso D., Laviola L., Lepore G., Bonfanti R., Bozzetto L., Corsi A., Di Blasi V., Girelli A., Grassi G., Iafusco D., Rabbone I., Schiaffini R., Montani V., Colleluori P., Paciotti V., Alfidi P., Grosso J., Tumini S., Cipriano P., Vitacolonna E., Di Vieste G., Minnucci A., Antenucci D., La Penna G., Taraborrelli M., Macerala B., Citro G., De Morelli G., Gnasso A., Irace C., Citriniti F., Lazzaro N., Bruzzese M., Mammi F., De Berardinis F., Santoro E., Corigliano G., Corigliano M., Parillo M., Schettino M., Fresa R., Annuzzi G., Bassi V., Santinelli C., Buono P., Mozzillo E., Russo V., De Feo E., Esposito K., Petrizzo M., Foglia A., Gatti A., Gentile S., Guarino G., Zanfardino A., Lambiase C., Vitale A., Zucchini S., Maltoni G., Forlani G., Moscatiello S., Suprani T., Bensa M., Tomasi F., Monesi M., Nizzoli M., Acquati S., Chierici G., Milli B., Iughetti L., Predieri B., Cavani R., Romano S., Manicardi V., Michelini M., Cimicchi M. C., Ugolotti D., Zavaroni I., Dei Cas A., Dall'Aglio E., Papi M., Tardio S. M., Calderini M. C., Riboni S., D'Amato L., Zavaroni D., Gastaldi L., Cirillo A., Di Bartolo P., Pellicano F., Di Secli C., Amarri S., Lasagni A., Marsciani A., Pedini A., Pagliani U., Rossi C., Tortul C., Brunato B., Assaloni R., Zanette G., Livolsi P., Petrucco A., Tercelj K., Manca E., Candido R., Tommasi E., Tornese G., Faleschini E., Tonutti L., Agus S., Zanatta M., Rosolen A., Comici A., Falasca P., Graziano F. M., Misischi I., Forte E., Palmacci C., Tuccinardi F., Ricciardi G. P., Di Masa P., Ragonese M., Cipolloni L., Buzzetti R., Moretti C., Leto G., Crino A., Bocchini S., Pozzilli P., Maurizi A. R., Di Perna P., Giuliano M., Frontoni S., Malandrucco I., Pitocco D., Scalpone R., Toscanella F., Cappa M., Ventura C., Bonato V., De Bernardinis M., Cavallo M. G., Leonetti F., Morano S., Mandosi E., Cicconetti E., Ciampittiello G., Marini M. A., Sabato D., Lauro D., Napoli A., Giraudo F., Toscano V., Pugliese G., Massimiani F., Fava D., Gargiulo P., Mecca N., Tubili C., Nardone M. R., Morviducci L., Manca-Bitti M. L., Arcano S., Leotta S., Suraci C., Chiaramonte F., Visalli N., Strollo F., Arnaldi C., Tosini D., Ponzani P., Patrone M., Guido R., Aglialoro A., Ghisoni G., Fabbri F., Bordone C., Maggi D., Cordera R., Minuto N., Rotondo E., Speranza D., Siri M., Carro S., Zappa A., Parmigiani S., Nieri S., Briatore L., Calvo G., Querci F., Trevisan R., Bonfadini S., Prandi E., Felappi B., Locatelli F., Fuso V., Rocca A., Meneghini E., Massafra C., Terni T., Elli P., Ruggeri P., Carrai E., Musacchio N., Marelli G., Vilei V., Richini D., Inversini C., Franzetti I., Bonacina M., Ciucci A., Sciangula L., Duratorre E., Bonomo M., Bertuzzi F., Chebat E., Muratori M., Scaramuzza A., Zuccotti G. V., Bollati P. 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G., Lapolla A., Portogruaro S., Zanon M., Lisato G., Mollo F., Calcaterra F., Miola M., Paccagnella A., Sambataro M., Moro E., Trombetta M., Negri C., Sabbion A., Maffeis C., Strazzabosco M., Mesturino C. A., and Mingardi R.

Abstract

Continuous subcutaneous insulin infusion (CSII) is increasingly being used worldwide, mostly thanks to technical improvements. This study examined the current status of CSII in Italy. Physicians in charge of 272 diabetes centers caring for patients using CSII were sent a questionnaire investigating clinical features, pump technology and management of these patients; a large proportion (217 centers, 79.8%) joined the study. By end-April 2013, data had been collected on 10152 patients treated with CSII; 98.2% had type 1 diabetes, 82.4% were adults, 57% female. Only just over half the centers (59%) managed more than 20 CSII patients each. The distribution of patients varied widely both among and within different regions. The main indication for CSII was the de- sire to improve glycemic control. Dropouts (8.65%) were mainly due to difficulties with pump wearability or non-optimal glycemic control. Among CSII patients 61% used a traditional pump, 39% a sensor augmented pump. Only 68% used the CSII advanced functions and glucose sensors were used twelve days per month on average. Round-the-clock assistance was guaranteed in 81% of centers; a full diabetes team followed patients in only 40% of adult-care centers and 50% of pediatric units. CSII is increasingly used in Italy, by adults and pediatric patients. However, further work is needed to unify treatment strategies throughout the country and to encourage optimal pump use and applications.

Published
2015

36. Continuous subcutaneous insulin infusion in Italy: Third national survey

Author

Bruttomesso, D, Laviola, L, Lepore, G, Bonfanti, R, Bozzetto, L, Corsi, A, Di Blasi, V, Girelli, A, Grassi, G, Iafusco, D, Rabbone, I, Schiaffini, R, Montani, V, Colleluori, P, Paciotti, V, Alfidi, P, Grosso, J, Tumini, S, Cipriano, P, Vitacolonna, E, Di Vieste, G, Minnucci, A, Antenucci, D, La Penna, G, Taraborrelli, M, Macerala, B, Citro, G, De Morelli, G, Gnasso, A, Irace, C, Citriniti, F, Lazzaro, N, Bruzzese, M, Mammi, F, De Berardinis, F, Santoro, E, Corigliano, G, Corigliano, M, Parillo, M, Schettino, M, Fresa, R, Annuzzi, G, Bassi, V, Santinelli, C, Buono, P, Mozzillo, E, De Feo, E, Esposito, K, Petrizzo, M, Foglia, A, Gatti, A, Gentile, S, Guarino, G, Zanfardino, A, Lambiase, C, Vitale, A, Zucchini, S, Maltoni, G, Forlani, G, Moscatiello, S, Suprani, T, Bensa, M, Tomasi, F, Monesi, M, Nizzoli, M, Acquati, S, Chierici, G, Milli, B, Iughetti, L, Predieri, B, Cavani, R, Romano, S, Manicardi, V, Michelini, M, Cimicchi, M, Ugolotti, D, Zavaroni, I, Dei Cas, A, Dall'Aglio, E, Papi, M, Tardio, S, Calderini, M, Riboni, S, D'Amato, L, Zavaroni, D, Gastaldi, L, Di Bartolo, P, Pellicano, F, Cirillo, A, Graziani, V, Di Secli, C, Amarri, S, Lasagni, A, Marsciani, A, Pedini, A, Pagliani, U, Rossi, C, Tortul, C, Brunato, B, Assaloni, R, Zanette, G, Livolsi, P, Petrucco, A, Tercelj, K, Manca, E, Candido, R, Tommasi, E, Tornese, G, Faleschini, E, Tonutti, L, Agus, S, Zanatta, M, Rosolen, A, Comici, A, Graziano, F, Misischi, I, Pozzilli, P, Maurizi, A, Falasca, P, Tuccinardi, F, Ricciardi, G, Di Masa, P, Ragonese, M, Cipolloni, L, Buzzetti, R, Moretti, C, Leto, G, Crino, A, Bocchini, S, Di Perna, P, Giuliano, M, Frontoni, S, Malandrucco, I, Pitocco, D, Scalpone, R, Toscanella, F, Cappa, M, Ventura, C, Bonato, V, De Bernardinis, M, Cavallo, M, Leonetti, F, Morano, S, Mandosi, E, Cicconetti, E, Ciampittiello, G, Marini, M, Sabato, D, Napoli, A, Giraudo, F, Toscano, V, Massimiani, F, Fava, D, Gargiulo, P, Mecca, N, Tubili, C, Nardone, M, Morviducci, L, Manca-Bitti, M, Arcano, S, Leotta, S, Suraci, C, Chiaramonte, F, Visalli, N, Forte, E, Palmacci, C, Arnaldi, C, Tosini, D, Querci, F, Trevisan, R, Bonfadini, S, Prandi, E, Felappi, B, Locatelli, F, Fuso, V, Rocca, A, Meneghini, E, Massafra, C, Terni, T, Elli, P, Ruggeri, P, Carrai, E, Musacchio, N, Lovagnini Scher, C, Marelli, G, Vilei, V, Richini, D, Inversini, C, Franzetti, I, Bonacina, M, Ciucci, A, Sciangula, L, Duratorre, E, Bonomo, M, Bertuzzi, F, Chebat, E, Muratori, M, Scaramuzza, A, Zuccotti, G, Bollati, P, Colapinto, P, Orsi, E, Palmieri, E, Laurenzi, A, Molinari, C, Frontino, G, Veronelli, A, Zecchini, B, Bianchi, A, Torchio, G, Lovati, E, Ghilardi, G, Dagani, R, Carugo, D, Berra, C, Favacchio, G, Fochesato, E, Pissarelli, A, Bucciarelli, L, Bulgheroni, M, Guerraggio, L, Zonca, S, Bossi, A, Berzi, D, Mangone, I, Cazzaniga, E, Rabini, R, Boemi, M, Faloia, E, Boscaro, M, Sternari, G, Iannilli, A, Cherubini, V, Busciantella Ricci, N, Cartechini, M, Tesei, A, Maolo, G, Galetta, M, Vespasiani, G, Tinti, G, Manfrini, S, Aiello, A, Di Vincenzo, S, Vitale, C, Di Caro, P, Lera, R, Secco, A, Lesina, A, Romeo, F, Origlia, C, Giorda, C, Chiambretti, A, Fornengo, R, De Donno, V, Gallarotti, F, Manti, R, Marafetti, L, Cadario, F, Savastio, S, Barbieri, P, Massucco, P, Ali, A, Gottero, C, Degiovanni, M, Bertaina, S, Maghenzani, G, Tinti, D, Fontana, F, Giorgino, F, Stefanelli, G, Cavallo, L, Zecchino, C, Piccinno, E, Ortolani, F, Gallo, F, Moramarco, F, Marino, A, Sparasci, G, Mileti, G, Lamacchia, O, Picca, G, Coccioli, M, Micale, F, Serra, R, Romano, I, Savino, T, De Cosmo, S, Rauseo, A, Delvecchio, M, Lapolla, R, Braione, A, Papagno, G, Baroni, M, Melis, M, Cossu, E, Songini, M, Cambuli, V, Lo Presti, D, Timpanaro, T, Chiavetta, A, Garofalo, M, Tommaselli, L, Tumminia, A, Scarpitta, A, Di Benedetto, A, Giunta, L, Lombardo, F, Salzano, G, Cardella, F, Roppolo, R, Provenzano, V, Fleres, M, Migliorini, S, De Luca, A, Leopardi, A, Beltrami, C, Toni, S, Guasti, G, Lenzi, L, Lamanna, C, Mannucci, 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V., Colleluori P., Paciotti V., Alfidi P., Grosso J., Tumini S., Cipriano P., Vitacolonna E., Di Vieste G., Minnucci A., Antenucci D., La Penna G., Taraborrelli M., Macerala B., Citro G., De Morelli G., Gnasso A., Irace C., Citriniti F., Lazzaro N., Bruzzese M., Mammi F., De Berardinis F., Santoro E., Corigliano G., Corigliano M., Parillo M., Schettino M., Fresa R., Annuzzi G., Bassi V., Santinelli C., Buono P., Mozzillo E., De Feo E., Esposito K., Petrizzo M., Foglia A., Gatti A., Gentile S., Guarino G., Zanfardino A., Lambiase C., Vitale A., Zucchini S., Maltoni G., Forlani G., Moscatiello S., Suprani T., Bensa M., Tomasi F., Monesi M., Nizzoli M., Acquati S., Chierici G., Milli B., Iughetti L., Predieri B., Cavani R., Romano S., Manicardi V., Michelini M., Cimicchi M. C., Ugolotti D., Zavaroni I., Dei Cas A., Dall'Aglio E., Papi M., Tardio S. M., Calderini M. C., Riboni S., D'Amato L., Zavaroni D., Gastaldi L., Di Bartolo P., Pellicano F., Cirillo A., Graziani V., Di Secli C., Amarri S., Lasagni A., Marsciani A., Pedini A., Pagliani U., Rossi C., Tortul C., Brunato B., Assaloni R., Zanette G., Livolsi P., Petrucco A., Tercelj K., Manca E., Candido R., Tommasi E., Tornese G., Faleschini E., Tonutti L., Agus S., Zanatta M., Rosolen A., Comici A., Graziano F. M., Misischi I., Pozzilli P., Maurizi A. R., Falasca P., Tuccinardi F., Ricciardi G. P., Di Masa P., Ragonese M., Cipolloni L., Buzzetti R., Moretti C., Leto G., Crino A., Bocchini S., Di Perna P., Giuliano M., Frontoni S., Malandrucco I., Pitocco D., Scalpone R., Toscanella F., Cappa M., Ventura C., Bonato V., De Bernardinis M., Cavallo M. G., Leonetti F., Morano S., Mandosi E., Cicconetti E., Ciampittiello G., Marini M. A., Sabato D., Napoli A., Giraudo F., Toscano V., Massimiani F., Fava D., Gargiulo P., Mecca N., Tubili C., Nardone M. R., Morviducci L., Manca-Bitti M. L., Arcano S., Leotta S., Suraci C., Chiaramonte F., Visalli N., Forte E., Palmacci C., Arnaldi C., Tosini D., Querci F., Trevisan R., Bonfadini S., Prandi E., Felappi B., Locatelli F., Fuso V., Rocca A., Meneghini E., Massafra C., Terni T., Elli P., Ruggeri P., Carrai E., Musacchio N., Lovagnini Scher C. A., Marelli G., Vilei V., Richini D., Inversini C., Franzetti I., Bonacina M., Ciucci A., Sciangula L., Duratorre E., Bonomo M., Bertuzzi F., Chebat E., Muratori M., Scaramuzza A., Zuccotti G. V., Bollati P. M., Colapinto P., Orsi E., Palmieri E., Laurenzi A., Molinari C., Frontino G., Veronelli A., Zecchini B., Bianchi A., Torchio G., Lovati E., Ghilardi G., Dagani R., Carugo D., Berra C., Favacchio G., Fochesato E., Pissarelli A., Bucciarelli L., Bulgheroni M., Guerraggio L., Zonca S., Bossi A. C., Berzi D., Mangone I., Cazzaniga E., Rabini R. A., Boemi M., Faloia E., Boscaro M., Sternari G., Iannilli A., Cherubini V., Busciantella Ricci N., Cartechini M. G., Tesei A. M., Maolo G., Galetta M., Vespasiani G., Tinti G., Manfrini S., Aiello A., Di Vincenzo S., Vitale C., Di Caro P., Lera R., Secco A., Lesina A., Romeo F., Origlia C., Giorda C., Chiambretti A. M., Fornengo R., De Donno V., Gallarotti F., Manti R., Marafetti L., Cadario F., Savastio S., Barbieri P., Massucco P., Ali A., Gottero C., Degiovanni M., Bertaina S., Maghenzani G., Tinti D., Fontana F., Giorgino F., Stefanelli G., Cavallo L., Zecchino C., Piccinno E., Ortolani F., Gallo F., Moramarco F., Marino A., Sparasci G., Mileti G., Lamacchia O., Picca G., Coccioli M. S., Micale F., Serra R., Romano I., Savino T., De Cosmo S., Rauseo A., Delvecchio M., Lapolla R., Braione A. F., Papagno G., Baroni M., Melis M., Cossu E., Songini M., Cambuli V. M., Lo Presti D., Timpanaro T. A., Chiavetta A., Garofalo M. R., Tommaselli L., Tumminia A., Scarpitta A. M., Di Benedetto A., Giunta L., Lombardo F., Salzano G., Cardella F., Roppolo R., Provenzano V., Fleres M., Migliorini S., De Luca A., Leopardi A., Beltrami C., Toni S., Guasti G., Lenzi L., Lamanna C., Mannucci E., Lucchesi S., Dicianni G., Aragona M., Del Prato S., Fattor B., Eisath J., Pasquino B., Reinstadler P., Kaufmann P., Incelli G., Rauch S., Romanelli T., Cauvin V., Franceschi R., Soldani C., Scattoni R., Norgiolini R., Celleno R., Torlone E., Bolli G. B., Lalli C., Scarponi M., Bobbio A., Bechaz M., Pianta A., Marangoni A., Arico C. N., Alagona C., Confortin L., Rossi E., Boscolo Bariga A., Nogara A., Bettio M., Frison V., Guidoni G. L., Fongher C., Contin M. L., Cosma A., Vianello S., Bondesan L., Morea A., Volpi A., Coracina A., Panebianco G., Lombardi S., Costa S., Cipponeri E., Vedovato M., Scotton R., Monciotti C. M., Galderisi A., Dalfra M. G., Lapolla A., Zanon M., Lisato G., Mollo F., Calcaterra F., Miola M., Paccagnella A., Sambataro M., Moro E., Trombetta M., Negri C., Sabbion A., Maffeis C., Strazzabosco M., Mesturino C. A., Mingardi R., Bruttomesso, D, Laviola, L, Lepore, G, Bonfanti, R, Bozzetto, L, Corsi, A, Di Blasi, V, Girelli, A, Grassi, G, Iafusco, D, Rabbone, I, Schiaffini, R, Montani, V, Colleluori, P, Paciotti, V, Alfidi, P, Grosso, J, Tumini, S, Cipriano, P, Vitacolonna, E, Di Vieste, G, Minnucci, A, Antenucci, D, La Penna, G, Taraborrelli, M, Macerala, B, Citro, G, De Morelli, G, Gnasso, A, Irace, C, Citriniti, F, Lazzaro, N, Bruzzese, M, Mammi, F, De Berardinis, F, Santoro, E, Corigliano, G, Corigliano, M, Parillo, M, Schettino, M, Fresa, R, Annuzzi, G, Bassi, V, Santinelli, C, Buono, P, Mozzillo, E, De Feo, E, Esposito, K, Petrizzo, M, Foglia, A, Gatti, A, Gentile, S, Guarino, G, Zanfardino, A, Lambiase, C, Vitale, A, Zucchini, S, Maltoni, G, Forlani, G, Moscatiello, S, Suprani, T, Bensa, M, Tomasi, F, Monesi, M, Nizzoli, M, Acquati, S, Chierici, G, Milli, B, Iughetti, L, Predieri, B, Cavani, R, Romano, S, Manicardi, V, Michelini, M, Cimicchi, M, Ugolotti, D, Zavaroni, I, Dei Cas, A, Dall'Aglio, E, Papi, M, Tardio, S, Calderini, M, Riboni, S, D'Amato, L, Zavaroni, D, Gastaldi, L, Di Bartolo, P, Pellicano, F, Cirillo, A, Graziani, V, Di Secli, C, Amarri, S, Lasagni, A, Marsciani, A, Pedini, A, Pagliani, U, Rossi, C, Tortul, C, Brunato, B, Assaloni, R, Zanette, G, Livolsi, P, Petrucco, A, Tercelj, K, Manca, E, Candido, R, Tommasi, E, Tornese, G, Faleschini, E, Tonutti, L, Agus, S, Zanatta, M, Rosolen, A, Comici, A, Graziano, F, Misischi, I, Pozzilli, P, Maurizi, A, Falasca, P, Tuccinardi, F, Ricciardi, G, Di Masa, P, Ragonese, M, Cipolloni, L, Buzzetti, R, Moretti, C, Leto, G, Crino, A, Bocchini, S, Di Perna, P, Giuliano, M, Frontoni, S, Malandrucco, I, Pitocco, D, Scalpone, R, Toscanella, F, Cappa, M, Ventura, C, Bonato, V, De Bernardinis, M, Cavallo, M, Leonetti, F, Morano, S, Mandosi, E, Cicconetti, E, Ciampittiello, G, Marini, M, Sabato, D, Napoli, A, Giraudo, F, Toscano, V, Massimiani, F, Fava, D, Gargiulo, P, Mecca, N, Tubili, C, Nardone, M, Morviducci, L, Manca-Bitti, M, Arcano, S, Leotta, S, Suraci, C, Chiaramonte, F, Visalli, N, Forte, E, Palmacci, C, Arnaldi, C, Tosini, D, Querci, F, Trevisan, R, Bonfadini, S, Prandi, E, Felappi, B, Locatelli, F, Fuso, V, Rocca, A, Meneghini, E, Massafra, C, Terni, T, Elli, P, Ruggeri, P, Carrai, E, Musacchio, N, Lovagnini Scher, C, Marelli, G, Vilei, V, Richini, D, Inversini, C, Franzetti, I, Bonacina, M, Ciucci, A, Sciangula, L, Duratorre, E, Bonomo, M, Bertuzzi, F, Chebat, E, Muratori, M, Scaramuzza, A, Zuccotti, G, Bollati, P, Colapinto, P, Orsi, E, Palmieri, E, Laurenzi, A, Molinari, C, Frontino, G, Veronelli, A, Zecchini, B, Bianchi, A, Torchio, G, Lovati, E, Ghilardi, G, Dagani, R, Carugo, D, Berra, C, Favacchio, G, Fochesato, E, Pissarelli, A, Bucciarelli, L, Bulgheroni, M, Guerraggio, L, Zonca, S, Bossi, A, Berzi, D, Mangone, I, Cazzaniga, E, Rabini, R, Boemi, M, Faloia, E, Boscaro, M, Sternari, G, Iannilli, A, Cherubini, V, Busciantella Ricci, N, Cartechini, M, Tesei, A, Maolo, G, Galetta, M, Vespasiani, G, Tinti, G, Manfrini, S, Aiello, A, Di Vincenzo, S, Vitale, C, Di Caro, P, Lera, R, Secco, A, Lesina, A, Romeo, F, Origlia, C, Giorda, C, Chiambretti, A, Fornengo, R, De Donno, V, Gallarotti, F, Manti, R, Marafetti, L, Cadario, F, Savastio, S, Barbieri, P, Massucco, P, Ali, A, Gottero, C, Degiovanni, M, Bertaina, S, Maghenzani, G, Tinti, D, Fontana, F, Giorgino, F, Stefanelli, G, Cavallo, L, Zecchino, C, Piccinno, E, Ortolani, F, Gallo, F, Moramarco, F, Marino, A, Sparasci, G, Mileti, G, Lamacchia, O, Picca, G, Coccioli, M, Micale, F, Serra, R, Romano, I, Savino, T, De Cosmo, S, Rauseo, A, Delvecchio, M, Lapolla, R, Braione, A, Papagno, G, Baroni, M, Melis, M, Cossu, E, Songini, M, Cambuli, V, Lo Presti, D, Timpanaro, T, Chiavetta, A, Garofalo, M, Tommaselli, L, Tumminia, A, Scarpitta, A, Di Benedetto, A, Giunta, L, Lombardo, F, Salzano, G, Cardella, F, Roppolo, R, Provenzano, V, Fleres, M, Migliorini, S, De Luca, A, Leopardi, A, Beltrami, C, Toni, S, Guasti, G, Lenzi, L, Lamanna, C, Mannucci, E, Lucchesi, S, Dicianni, G, Aragona, M, Del Prato, S, Fattor, B, Eisath, J, Pasquino, B, Reinstadler, P, Kaufmann, P, Incelli, G, Rauch, S, Romanelli, T, Cauvin, V, Franceschi, R, Soldani, C, Scattoni, R, Norgiolini, R, Celleno, R, Torlone, E, Bolli, G, Lalli, C, Scarponi, M, Bobbio, A, Bechaz, M, Pianta, A, Marangoni, A, Arico, C, Alagona, C, Confortin, L, Rossi, E, Boscolo Bariga, A, Nogara, A, Bettio, M, Frison, V, Guidoni, G, Fongher, C, Contin, M, Cosma, A, Vianello, S, Bondesan, L, Morea, A, Volpi, A, Coracina, A, Panebianco, G, Lombardi, S, Costa, S, Cipponeri, E, Vedovato, M, Scotton, R, Monciotti, C, Galderisi, A, Dalfra, M, Lapolla, A, Zanon, M, Lisato, G, Mollo, F, Calcaterra, F, Miola, M, Paccagnella, A, Sambataro, M, Moro, E, Trombetta, M, Negri, C, Sabbion, A, Maffeis, C, Strazzabosco, M, Mesturino, C, Mingardi, R, Bruttomesso D., Laviola L., Lepore G., Bonfanti R., Bozzetto L., Corsi A., Di Blasi V., Girelli A., Grassi G., Iafusco D., Rabbone I., Schiaffini R., Montani V., Colleluori P., Paciotti V., Alfidi P., Grosso J., Tumini S., Cipriano P., Vitacolonna E., Di Vieste G., Minnucci A., Antenucci D., La Penna G., Taraborrelli M., Macerala B., Citro G., De Morelli G., Gnasso A., Irace C., Citriniti F., Lazzaro N., Bruzzese M., Mammi F., De Berardinis F., Santoro E., Corigliano G., Corigliano M., Parillo M., Schettino M., Fresa R., Annuzzi G., Bassi V., Santinelli C., Buono P., Mozzillo E., De Feo E., Esposito K., Petrizzo M., Foglia A., Gatti A., Gentile S., Guarino G., Zanfardino A., Lambiase C., Vitale A., Zucchini S., Maltoni G., Forlani G., Moscatiello S., Suprani T., Bensa M., Tomasi F., Monesi M., Nizzoli M., Acquati S., Chierici G., Milli B., Iughetti L., Predieri B., Cavani R., Romano S., Manicardi V., Michelini M., Cimicchi M. C., Ugolotti D., Zavaroni I., Dei Cas A., Dall'Aglio E., Papi M., Tardio S. M., Calderini M. C., Riboni S., D'Amato L., Zavaroni D., Gastaldi L., Di Bartolo P., Pellicano F., Cirillo A., Graziani V., Di Secli C., Amarri S., Lasagni A., Marsciani A., Pedini A., Pagliani U., Rossi C., Tortul C., Brunato B., Assaloni R., Zanette G., Livolsi P., Petrucco A., Tercelj K., Manca E., Candido R., Tommasi E., Tornese G., Faleschini E., Tonutti L., Agus S., Zanatta M., Rosolen A., Comici A., Graziano F. M., Misischi I., Pozzilli P., Maurizi A. R., Falasca P., Tuccinardi F., Ricciardi G. P., Di Masa P., Ragonese M., Cipolloni L., Buzzetti R., Moretti C., Leto G., Crino A., Bocchini S., Di Perna P., Giuliano M., Frontoni S., Malandrucco I., Pitocco D., Scalpone R., Toscanella F., Cappa M., Ventura C., Bonato V., De Bernardinis M., Cavallo M. G., Leonetti F., Morano S., Mandosi E., Cicconetti E., Ciampittiello G., Marini M. A., Sabato D., Napoli A., Giraudo F., Toscano V., Massimiani F., Fava D., Gargiulo P., Mecca N., Tubili C., Nardone M. R., Morviducci L., Manca-Bitti M. L., Arcano S., Leotta S., Suraci C., Chiaramonte F., Visalli N., Forte E., Palmacci C., Arnaldi C., Tosini D., Querci F., Trevisan R., Bonfadini S., Prandi E., Felappi B., Locatelli F., Fuso V., Rocca A., Meneghini E., Massafra C., Terni T., Elli P., Ruggeri P., Carrai E., Musacchio N., Lovagnini Scher C. A., Marelli G., Vilei V., Richini D., Inversini C., Franzetti I., Bonacina M., Ciucci A., Sciangula L., Duratorre E., Bonomo M., Bertuzzi F., Chebat E., Muratori M., Scaramuzza A., Zuccotti G. V., Bollati P. M., Colapinto P., Orsi E., Palmieri E., Laurenzi A., Molinari C., Frontino G., Veronelli A., Zecchini B., Bianchi A., Torchio G., Lovati E., Ghilardi G., Dagani R., Carugo D., Berra C., Favacchio G., Fochesato E., Pissarelli A., Bucciarelli L., Bulgheroni M., Guerraggio L., Zonca S., Bossi A. C., Berzi D., Mangone I., Cazzaniga E., Rabini R. A., Boemi M., Faloia E., Boscaro M., Sternari G., Iannilli A., Cherubini V., Busciantella Ricci N., Cartechini M. G., Tesei A. M., Maolo G., Galetta M., Vespasiani G., Tinti G., Manfrini S., Aiello A., Di Vincenzo S., Vitale C., Di Caro P., Lera R., Secco A., Lesina A., Romeo F., Origlia C., Giorda C., Chiambretti A. M., Fornengo R., De Donno V., Gallarotti F., Manti R., Marafetti L., Cadario F., Savastio S., Barbieri P., Massucco P., Ali A., Gottero C., Degiovanni M., Bertaina S., Maghenzani G., Tinti D., Fontana F., Giorgino F., Stefanelli G., Cavallo L., Zecchino C., Piccinno E., Ortolani F., Gallo F., Moramarco F., Marino A., Sparasci G., Mileti G., Lamacchia O., Picca G., Coccioli M. S., Micale F., Serra R., Romano I., Savino T., De Cosmo S., Rauseo A., Delvecchio M., Lapolla R., Braione A. F., Papagno G., Baroni M., Melis M., Cossu E., Songini M., Cambuli V. M., Lo Presti D., Timpanaro T. A., Chiavetta A., Garofalo M. R., Tommaselli L., Tumminia A., Scarpitta A. M., Di Benedetto A., Giunta L., Lombardo F., Salzano G., Cardella F., Roppolo R., Provenzano V., Fleres M., Migliorini S., De Luca A., Leopardi A., Beltrami C., Toni S., Guasti G., Lenzi L., Lamanna C., Mannucci E., Lucchesi S., Dicianni G., Aragona M., Del Prato S., Fattor B., Eisath J., Pasquino B., Reinstadler P., Kaufmann P., Incelli G., Rauch S., Romanelli T., Cauvin V., Franceschi R., Soldani C., Scattoni R., Norgiolini R., Celleno R., Torlone E., Bolli G. B., Lalli C., Scarponi M., Bobbio A., Bechaz M., Pianta A., Marangoni A., Arico C. N., Alagona C., Confortin L., Rossi E., Boscolo Bariga A., Nogara A., Bettio M., Frison V., Guidoni G. L., Fongher C., Contin M. L., Cosma A., Vianello S., Bondesan L., Morea A., Volpi A., Coracina A., Panebianco G., Lombardi S., Costa S., Cipponeri E., Vedovato M., Scotton R., Monciotti C. M., Galderisi A., Dalfra M. G., Lapolla A., Zanon M., Lisato G., Mollo F., Calcaterra F., Miola M., Paccagnella A., Sambataro M., Moro E., Trombetta M., Negri C., Sabbion A., Maffeis C., Strazzabosco M., Mesturino C. A., and Mingardi R.

Abstract

Background: Continuous subcutaneous insulin infusion (CSII) is increasing worldwide, mostly because of improved technology. The aim of this study was to evaluate the current status of CSII in Italy. Materials and Methods: Physicians from 272 diabetes centers received a questionnaire investigating clinical features, pump technology, and management of patients on CSII. Results: Two hundred seventeen centers (79.8%) joined the study and, by the end of April 2013, gave information about 10,152 patients treated with CSII: 98.2% with type 1 diabetes mellitus, 81.4% adults, 57% female, and 61% with a conventional pump versus 39% with a sensor-augmented pump. CSII advanced functions were used by 68% of patients, and glucose sensors were used 12 days per month on average. Fifty-eight percent of diabetes centers had more than 20 patients on CSII, but there were differences among centers and among regions. The main indication for CSII was poor glucose control. Dropout was mainly due to pump wearability or nonoptimal glycemic control. Twenty-four hour assistance was guaranteed in 81% of centers. A full diabetes team (physician+ nurse + dietician + psychologist) was available in 23% of adult-care diabetes centers and in 53%of pediatric diabetes units. Conclusions: CSII keeps increasing in Italy. More work is needed to ensure uniform treatment strategies throughout the country and to improve pump use.

Published
2015

37. The 30-day metric in acute heart failure revisited: data from IN-HF Outcome, an Italian nationwide cardiology registry

Author

Di Tano, G, De Maria, R, Gonzini, L, Aspromonte, N, Di Lenarda, A, Feola, M, Marini, M, Milli, M, Misuraca, G, Mortara, A, Oliva, F, Pulignano, G, Russo, G, Senni, M, Tavazzi, L, Di Tano G, De Maria R, Gonzini L, Aspromonte N, Di Lenarda A, Feola M, Marini M, Milli M, Misuraca G, Mortara A, Oliva F, Pulignano G, Russo G, Senni M, Tavazzi L, Di Tano, G, De Maria, R, Gonzini, L, Aspromonte, N, Di Lenarda, A, Feola, M, Marini, M, Milli, M, Misuraca, G, Mortara, A, Oliva, F, Pulignano, G, Russo, G, Senni, M, Tavazzi, L, Di Tano G, De Maria R, Gonzini L, Aspromonte N, Di Lenarda A, Feola M, Marini M, Milli M, Misuraca G, Mortara A, Oliva F, Pulignano G, Russo G, Senni M, and Tavazzi L

Abstract

Aims Unplanned readmissions early after a discharge from acute heart failure hospitalization are common and have become a reimbursement benchmark and marker of hospital quality. However, the competing risk of short-term post-discharge mortality is substantial. Methods and results Using data from the prospective, nationwide Registry IN-HF Outcome, we analysed the incidence and predictors of 30-day mortality or readmissions and associated days-alive-out-of-hospital (DAOH) in 1520 patients discharged alive after admission for acute heart failure. Within 30 days after discharge, 94 patients (6.2%) were readmitted (91% for cardiovascular causes; 60% recurrent heart failure) and 42 (2.8%) died, 10 of which occurred during readmission. Overall, 126 patients (8.3%) met the combined endpoint. By multivariable logistic regression, worsening chronic heart failure as clinical presentation [odds ratio (OR) 1.83, 95% confidence interval (CI) 1.21-2.77, P = 0.005), inotropes during admission (OR 2.19, 95% CI 1.40-3.43, P = 0.0006), length of stay (OR 1.02, 95% CI 1.01-1.04, P = 0.002) and renin-angiotensin system inhibitors at discharge (OR 0.52, 95%CI 0.35-0.77, P = 0.001) independently predicted 30-day all-cause mortality and/or readmission (c-statistic = 0.695). Per cent 30-day DAOH was lower in patients with in-hospital inotrope use, no renin-angiotensin system inhibitors prescription at discharge, New York Heart Association III-IV class at discharge, and correlated inversely with length of stay and age. Conclusion A clinical and biohumoral profile consistent with chronic advanced heart failure and end-organ damage identifies acute heart failure patients discharged home from cardiology units, who are at highest risk of early death and/or readmission. These findings have practical implications for tailoring specific follow-up.

Published
2015

38. A standardized flow cytometry network study for the assessment of circulating endothelial cell physiological ranges

Author

Lanuti, P, Simeone, P, Rotta, G, Almici, C, Avvisati, G, Azzaro, R, Bologna, G, Budillon, A, Di Cerbo, M, Di Gennaro, E, Di Martino, M, Diodato, A, Doretto, P, Ercolino, E, Falda, A, Gregorj, C, Leone, A, Losa, F, Malara, N, Marini, M, Mastroroberto, P, Mollace, V, Morelli, M, Muggianu, E, Musolino, G, Neva, A, Pierdomenico, L, Pinna, S, Piovani, G, Roca, M, Russo, D, Scotti, L, Tirindelli, M, Trunzo, V, Venturella, R, Vitagliano, C, Zullo, F, Marchisio, M, Miscia, S, Lanuti, Paola, Simeone, Pasquale, Rotta, Gianluca, Almici, Camillo, Avvisati, Giuseppe, Azzaro, Rosa, Bologna, Giuseppina, Budillon, Alfredo, Di Cerbo, Melania, Di Gennaro, Elena, Di Martino, Maria Luisa, Diodato, Annamaria, Doretto, Paolo, Ercolino, Eva, Falda, Alessandra, Gregorj, Chiara, Leone, Alessandra, Losa, Francesca, Malara, Natalia, Marini, Mirella, Mastroroberto, Pasquale, Mollace, Vincenzo, Morelli, Michele, Muggianu, Emma, Musolino, Giuseppe, Neva, Arabella, Pierdomenico, Laura, Pinna, Silvia, Piovani, Giovanna, Roca, Maria Serena, Russo, Domenico, Scotti, Lorenza, Tirindelli, Maria Cristina, Trunzo, Valentina, Venturella, Roberta, Vitagliano, Carlo, Zullo, Fulvio, Marchisio, Marco, Miscia, Sebastiano, Lanuti, P, Simeone, P, Rotta, G, Almici, C, Avvisati, G, Azzaro, R, Bologna, G, Budillon, A, Di Cerbo, M, Di Gennaro, E, Di Martino, M, Diodato, A, Doretto, P, Ercolino, E, Falda, A, Gregorj, C, Leone, A, Losa, F, Malara, N, Marini, M, Mastroroberto, P, Mollace, V, Morelli, M, Muggianu, E, Musolino, G, Neva, A, Pierdomenico, L, Pinna, S, Piovani, G, Roca, M, Russo, D, Scotti, L, Tirindelli, M, Trunzo, V, Venturella, R, Vitagliano, C, Zullo, F, Marchisio, M, Miscia, S, Lanuti, Paola, Simeone, Pasquale, Rotta, Gianluca, Almici, Camillo, Avvisati, Giuseppe, Azzaro, Rosa, Bologna, Giuseppina, Budillon, Alfredo, Di Cerbo, Melania, Di Gennaro, Elena, Di Martino, Maria Luisa, Diodato, Annamaria, Doretto, Paolo, Ercolino, Eva, Falda, Alessandra, Gregorj, Chiara, Leone, Alessandra, Losa, Francesca, Malara, Natalia, Marini, Mirella, Mastroroberto, Pasquale, Mollace, Vincenzo, Morelli, Michele, Muggianu, Emma, Musolino, Giuseppe, Neva, Arabella, Pierdomenico, Laura, Pinna, Silvia, Piovani, Giovanna, Roca, Maria Serena, Russo, Domenico, Scotti, Lorenza, Tirindelli, Maria Cristina, Trunzo, Valentina, Venturella, Roberta, Vitagliano, Carlo, Zullo, Fulvio, Marchisio, Marco, and Miscia, Sebastiano

Abstract

Circulating endothelial cells (CEC) represent a restricted peripheral blood (PB) cell subpopulation with high potential diagnostic value in many endothelium-involving diseases. However, whereas the interest in CEC studies has grown, the standardization level of their detection has not. Here, we undertook the task to align CEC phenotypes and counts, by standardizing a novel flow cytometry approach, within a network of six laboratories. CEC were identified as alive/nucleated/CD45negative/CD34bright/CD146positive events and enumerated in 269 healthy PB samples. Standardization was demonstrated by the achievement of low inter-laboratory Coefficients of Variation (CVL), calculated on the basis of Median Fluorescence Intensity values of the most stable antigens that allowed CEC identification and count (CVL of CD34bright on CEC ∼ 30%; CVL of CD45 on Lymphocytes ∼ 20%). By aggregating data acquired from all sites, CEC numbers in the healthy population were captured (medianfemale = 9.31 CEC/mL; medianmale = 11.55 CEC/mL). CEC count biological variability and method specificity were finally assessed. Results, obtained on a large population of donors, demonstrate that the established procedure might be adopted as standardized method for CEC analysis in clinical and in research settings, providing a CEC physiological baseline range, useful as starting point for their clinical monitoring in endothelial dysfunctions.

Published
2018

39. Plankton dynamics across the freshwater, transitional and marine research sites of the LTER-Italy Network. Patterns, fluctuations, drivers

Author

Morabito, G, Mazzocchi, M, Salmaso, N, Zingone, A, Bergami, C, Flaim, G, Accoroni, S, Basset, A, Bastianini, M, Belmonte, G, Bernardi Aubry, F, Bertani, I, Bresciani, M, Buzzi, F, Cabrini, M, Camatti, E, Caroppo, C, Cataletto, B, Castellano, M, Del Negro, P, de Olazabal, A, Di Capua, I, Elia, A, Fornasaro, D, Giallain, M, Grilli, F, Leoni, B, Lipizer, M, Longobardi, L, Ludovisi, A, Lugliè, A, Manca, M, Margiotta, F, Mariani, M, Marini, M, Marzocchi, M, Obertegger, U, Oggioni, A, Padedda, B, Pansera, M, Piscia, R, Povero, P, Pulina, S, Romagnoli, T, Rosati, I, Rossetti, G, Rubino, F, Sarno, D, Satta, C, Sechi, N, Stanca, E, Tirelli, V, Totti, C, Pugnetti, A, Mazzocchi, MG, Elia, AC, Mariani, MA, Padedda, BM, Satta, CT, Morabito, G, Mazzocchi, M, Salmaso, N, Zingone, A, Bergami, C, Flaim, G, Accoroni, S, Basset, A, Bastianini, M, Belmonte, G, Bernardi Aubry, F, Bertani, I, Bresciani, M, Buzzi, F, Cabrini, M, Camatti, E, Caroppo, C, Cataletto, B, Castellano, M, Del Negro, P, de Olazabal, A, Di Capua, I, Elia, A, Fornasaro, D, Giallain, M, Grilli, F, Leoni, B, Lipizer, M, Longobardi, L, Ludovisi, A, Lugliè, A, Manca, M, Margiotta, F, Mariani, M, Marini, M, Marzocchi, M, Obertegger, U, Oggioni, A, Padedda, B, Pansera, M, Piscia, R, Povero, P, Pulina, S, Romagnoli, T, Rosati, I, Rossetti, G, Rubino, F, Sarno, D, Satta, C, Sechi, N, Stanca, E, Tirelli, V, Totti, C, Pugnetti, A, Mazzocchi, MG, Elia, AC, Mariani, MA, Padedda, BM, and Satta, CT

Abstract

A first synoptic and trans-domain overviewof plankton dynamics was conducted across the aquatic sites belonging to the Italian Long-Term Ecological Research Network (LTER-Italy). Based on published studies, checked and complemented with unpublished information, we investigated phytoplankton and zooplankton annual dynamics and long-term changes across domains: from the large subalpine lakes to mountain lakes and artificial lakes, from lagoons to marine coastal ecosystems. This study permitted identifying common and unique environmental drivers and ecological functional processes controlling seasonal and long-termtemporal course. The most relevant patterns of plankton seasonal succession were revealed, showing that the driving factors were nutrient availability, stratification regime, and freshwater inflow. Phytoplankton and mesozooplankton displayed a wide interannual variability at most sites. Unidirectional or linear long-term trends were rarely detected but all sites were impacted across the years by at least one, but in many case several major stressor(s): nutrient inputs, meteo-climatic variability at the local and regional scale, and direct human activities at specific sites. Different climatic and anthropic forcings frequently co-occurred, whereby the responses of plankton communities were the result of this environmental complexity. Overall, the LTER investigations are providing an unparalleled framework of knowledge to evaluate changes in the aquatic pelagic systems and management options

Published
2018

40. Evolutionary oligopoly games with heterogeneous adaptive players

Author

Corchón L.-C., Marini M. A., Bischi, G. I., Lamantia, F., Radi, Davide, Radi D. (ORCID:0000-0001-7809-1166), Corchón L.-C., Marini M. A., Bischi, G. I., Lamantia, F., Radi, Davide, and Radi D. (ORCID:0000-0001-7809-1166)

Abstract

In this chapter, we analyze the properties of evolutionary switching models for oligopoly games, where boundedly rational agents can follow different behavioral rules (or heuristics) to update their production through repeated adaptive decisions. In particular, we focus on well-known heuristics such as best reply with naive expectations, local monopolistic approximation and gradient dynamics on marginal profits. These heuristics are characterized by the property that Nash equilibria are fixed points of the corresponding dynamic processes. The population of firms in the oligopoly is subdivided into fractions of adopters of the different heuristics. Firms are allowed to switch over time between different behavioral rules according to profit-driven evolutionary pressure. The chapter examines some specific examples of evolutionary systems. Coexistence of heterogeneous behaviors as well as oscillatory time patterns are obtained as possible outcomes of the proposed evolutionary models

Published
2018

41. A standardized flow cytometry network study for the assessment of circulating endothelial cell physiological ranges

Author

Lanuti, P, Simeone, P, Rotta, G, Almici, C, Avvisati, G, Azzaro, R, Bologna, G, Budillon, A, Di Cerbo, M, Di Gennaro, E, Di Martino, M, Diodato, A, Doretto, P, Ercolino, E, Falda, A, Gregorj, C, Leone, A, Losa, F, Malara, N, Marini, M, Mastroroberto, P, Mollace, V, Morelli, M, Muggianu, E, Musolino, G, Neva, A, Pierdomenico, L, Pinna, S, Piovani, G, Roca, M, Russo, D, Scotti, L, Tirindelli, M, Trunzo, V, Venturella, R, Vitagliano, C, Zullo, F, Marchisio, M, Miscia, S, Lanuti, Paola, Simeone, Pasquale, Rotta, Gianluca, Almici, Camillo, Avvisati, Giuseppe, Azzaro, Rosa, Bologna, Giuseppina, Budillon, Alfredo, Di Cerbo, Melania, Di Gennaro, Elena, Di Martino, Maria Luisa, Diodato, Annamaria, Doretto, Paolo, Ercolino, Eva, Falda, Alessandra, Gregorj, Chiara, Leone, Alessandra, Losa, Francesca, Malara, Natalia, Marini, Mirella, Mastroroberto, Pasquale, Mollace, Vincenzo, Morelli, Michele, Muggianu, Emma, Musolino, Giuseppe, Neva, Arabella, Pierdomenico, Laura, Pinna, Silvia, Piovani, Giovanna, Roca, Maria Serena, Russo, Domenico, Scotti, Lorenza, Tirindelli, Maria Cristina, Trunzo, Valentina, Venturella, Roberta, Vitagliano, Carlo, Zullo, Fulvio, Marchisio, Marco, Miscia, Sebastiano, Lanuti, P, Simeone, P, Rotta, G, Almici, C, Avvisati, G, Azzaro, R, Bologna, G, Budillon, A, Di Cerbo, M, Di Gennaro, E, Di Martino, M, Diodato, A, Doretto, P, Ercolino, E, Falda, A, Gregorj, C, Leone, A, Losa, F, Malara, N, Marini, M, Mastroroberto, P, Mollace, V, Morelli, M, Muggianu, E, Musolino, G, Neva, A, Pierdomenico, L, Pinna, S, Piovani, G, Roca, M, Russo, D, Scotti, L, Tirindelli, M, Trunzo, V, Venturella, R, Vitagliano, C, Zullo, F, Marchisio, M, Miscia, S, Lanuti, Paola, Simeone, Pasquale, Rotta, Gianluca, Almici, Camillo, Avvisati, Giuseppe, Azzaro, Rosa, Bologna, Giuseppina, Budillon, Alfredo, Di Cerbo, Melania, Di Gennaro, Elena, Di Martino, Maria Luisa, Diodato, Annamaria, Doretto, Paolo, Ercolino, Eva, Falda, Alessandra, Gregorj, Chiara, Leone, Alessandra, Losa, Francesca, Malara, Natalia, Marini, Mirella, Mastroroberto, Pasquale, Mollace, Vincenzo, Morelli, Michele, Muggianu, Emma, Musolino, Giuseppe, Neva, Arabella, Pierdomenico, Laura, Pinna, Silvia, Piovani, Giovanna, Roca, Maria Serena, Russo, Domenico, Scotti, Lorenza, Tirindelli, Maria Cristina, Trunzo, Valentina, Venturella, Roberta, Vitagliano, Carlo, Zullo, Fulvio, Marchisio, Marco, and Miscia, Sebastiano

Abstract

Circulating endothelial cells (CEC) represent a restricted peripheral blood (PB) cell subpopulation with high potential diagnostic value in many endothelium-involving diseases. However, whereas the interest in CEC studies has grown, the standardization level of their detection has not. Here, we undertook the task to align CEC phenotypes and counts, by standardizing a novel flow cytometry approach, within a network of six laboratories. CEC were identified as alive/nucleated/CD45negative/CD34bright/CD146positive events and enumerated in 269 healthy PB samples. Standardization was demonstrated by the achievement of low inter-laboratory Coefficients of Variation (CVL), calculated on the basis of Median Fluorescence Intensity values of the most stable antigens that allowed CEC identification and count (CVL of CD34bright on CEC ∼ 30%; CVL of CD45 on Lymphocytes ∼ 20%). By aggregating data acquired from all sites, CEC numbers in the healthy population were captured (medianfemale = 9.31 CEC/mL; medianmale = 11.55 CEC/mL). CEC count biological variability and method specificity were finally assessed. Results, obtained on a large population of donors, demonstrate that the established procedure might be adopted as standardized method for CEC analysis in clinical and in research settings, providing a CEC physiological baseline range, useful as starting point for their clinical monitoring in endothelial dysfunctions.

Published
2018

42. Plankton dynamics across the freshwater, transitional and marine research sites of the LTER-Italy Network. Patterns, fluctuations, drivers

Author

Morabito, G, Mazzocchi, M, Salmaso, N, Zingone, A, Bergami, C, Flaim, G, Accoroni, S, Basset, A, Bastianini, M, Belmonte, G, Bernardi Aubry, F, Bertani, I, Bresciani, M, Buzzi, F, Cabrini, M, Camatti, E, Caroppo, C, Cataletto, B, Castellano, M, Del Negro, P, de Olazabal, A, Di Capua, I, Elia, A, Fornasaro, D, Giallain, M, Grilli, F, Leoni, B, Lipizer, M, Longobardi, L, Ludovisi, A, Lugliè, A, Manca, M, Margiotta, F, Mariani, M, Marini, M, Marzocchi, M, Obertegger, U, Oggioni, A, Padedda, B, Pansera, M, Piscia, R, Povero, P, Pulina, S, Romagnoli, T, Rosati, I, Rossetti, G, Rubino, F, Sarno, D, Satta, C, Sechi, N, Stanca, E, Tirelli, V, Totti, C, Pugnetti, A, Mazzocchi, MG, Elia, AC, Mariani, MA, Padedda, BM, Satta, CT, Morabito, G, Mazzocchi, M, Salmaso, N, Zingone, A, Bergami, C, Flaim, G, Accoroni, S, Basset, A, Bastianini, M, Belmonte, G, Bernardi Aubry, F, Bertani, I, Bresciani, M, Buzzi, F, Cabrini, M, Camatti, E, Caroppo, C, Cataletto, B, Castellano, M, Del Negro, P, de Olazabal, A, Di Capua, I, Elia, A, Fornasaro, D, Giallain, M, Grilli, F, Leoni, B, Lipizer, M, Longobardi, L, Ludovisi, A, Lugliè, A, Manca, M, Margiotta, F, Mariani, M, Marini, M, Marzocchi, M, Obertegger, U, Oggioni, A, Padedda, B, Pansera, M, Piscia, R, Povero, P, Pulina, S, Romagnoli, T, Rosati, I, Rossetti, G, Rubino, F, Sarno, D, Satta, C, Sechi, N, Stanca, E, Tirelli, V, Totti, C, Pugnetti, A, Mazzocchi, MG, Elia, AC, Mariani, MA, Padedda, BM, and Satta, CT

Abstract

A first synoptic and trans-domain overviewof plankton dynamics was conducted across the aquatic sites belonging to the Italian Long-Term Ecological Research Network (LTER-Italy). Based on published studies, checked and complemented with unpublished information, we investigated phytoplankton and zooplankton annual dynamics and long-term changes across domains: from the large subalpine lakes to mountain lakes and artificial lakes, from lagoons to marine coastal ecosystems. This study permitted identifying common and unique environmental drivers and ecological functional processes controlling seasonal and long-termtemporal course. The most relevant patterns of plankton seasonal succession were revealed, showing that the driving factors were nutrient availability, stratification regime, and freshwater inflow. Phytoplankton and mesozooplankton displayed a wide interannual variability at most sites. Unidirectional or linear long-term trends were rarely detected but all sites were impacted across the years by at least one, but in many case several major stressor(s): nutrient inputs, meteo-climatic variability at the local and regional scale, and direct human activities at specific sites. Different climatic and anthropic forcings frequently co-occurred, whereby the responses of plankton communities were the result of this environmental complexity. Overall, the LTER investigations are providing an unparalleled framework of knowledge to evaluate changes in the aquatic pelagic systems and management options

Published
2018

43. INSIGHT responsive parenting intervention reduces infant's screen time and television exposure

Author

Adams, Elisabeth, Marini, M., Stokes, J., Birch, L., Paul, I., Savage, J., Adams, Elisabeth, Marini, M., Stokes, J., Birch, L., Paul, I., and Savage, J.

Abstract

Background: Sedentary behaviors, including screen time, in childhood have been associated with an increased risk for overweight. Beginning in infancy, we sought to reduce screen time and television exposure and increase time spent in interactive play as one component of a responsive parenting (RP) intervention designed for obesity prevention. Methods: The Intervention Nurses Start Infants Growing on Healthy Trajectories (INSIGHT) study is a randomized trial comparing a RP intervention with a safety control intervention. Primiparous mother-newborn dyads (N = 279) were randomized after childbirth. Research nurses delivered intervention content at infant ages 3, 16, 28, and 40 weeks and research center visits at 1 and 2 years. As one component of INSIGHT, developmentally appropriate messages on minimizing screen time, reducing television exposure in the home, and promoting parent-child engagement through interactive play were delivered. Mothers self-reported their infant's screen time at ages 44 weeks, 1, 1.5, 2 and 2.5 years; interactive play was reported at 8 and 20 weeks and 2 years. Results: More RP than control parents reported their infants met the American Academy of Pediatrics' no screen time recommendation at 44 weeks (53.0% vs. 30.2%) and at 1 year on weekdays (42.5% vs. 27.6%) and weekends (45.5% vs. 26.8%), but not after age 1 year. RP mothers and RP children had less daily screen time than controls at each time point (p ≤ 0.01). Fewer RP than control group mothers reported the television was ever on during infant meals (p < 0.05). The frequency of tummy time and floor play did not differ by study group; approximately 95% of infants spent time in restrictive devices (i.e. swing) at 8 and 20 weeks. At 2 years of age, there were no study group differences for time children spent in interactive play. Conclusion: From infancy to early childhood, the INSIGHT RP intervention reduced screen time and television exposure, but did not increase the frequency or a

Published
2018

44. Emerging patterns for niche scaling-up processes in socio-technical transitions. Evidence from green shared transport in Amsterdam

Author

Marini, M., Uittenbroek, C. (Thesis Advisor), Marini, M., and Uittenbroek, C. (Thesis Advisor)

Abstract

It is widely acknowledged that human activities are primary responsible for accelerating climate change at a global scale. Within the societal sectors, transport is one of the main contributors to harmful emission in the atmosphere, and governmental bodies are struggling to provide alternative solutions to reduce the impact of transport sector on both natural and societal systems. The XXI century has witnessed the rapid growth of sharing practices in cities, which affected mobility as well. Among European cities, Amsterdam is taking a decisive step to drive a socio-technical transition by integrating sharing concepts with electric transport, one of the main alternatives to polluting vehicles. Green shared transport can contribute to mitigate both emissions and congestion issues, but the extent to which this innovation can be extended to a larger scale is not adequately addressed yet. The main question is therefore “What are the main explanatory factors of the scaling-up of the green shared transport niche in Amsterdam, in the context of societal transition?”. To answer this question, an extensive literature review was first conducted in order to identify the main theories dealing with transitions processes and niche markets, identified in Multi-Level Perspective, Strategic Niche Management and internal niche dynamics. These last two in particular provided a number of conditions to be assessed during the analysis, and a scoring criteria was established to determine the importance of those factors. Second, a methodological approach was developed in order to gather qualitative data from organisations operating in the green shared mobility domain in Amsterdam. The conditions identified within the theoretical approach were addressed to appraise the potential for the niche to scale-up. The main policy approaches aiming at promoting sustainable transport at local level were considered as well. After the coding process, the results were evaluated on the basis of stakeholder

Published
2017

45. Emerging patterns for niche scaling-up processes in socio-technical transitions. Evidence from green shared transport in Amsterdam

Author

Marini, M., Uittenbroek, C. (Thesis Advisor), Marini, M., and Uittenbroek, C. (Thesis Advisor)

Abstract

It is widely acknowledged that human activities are primary responsible for accelerating climate change at a global scale. Within the societal sectors, transport is one of the main contributors to harmful emission in the atmosphere, and governmental bodies are struggling to provide alternative solutions to reduce the impact of transport sector on both natural and societal systems. The XXI century has witnessed the rapid growth of sharing practices in cities, which affected mobility as well. Among European cities, Amsterdam is taking a decisive step to drive a socio-technical transition by integrating sharing concepts with electric transport, one of the main alternatives to polluting vehicles. Green shared transport can contribute to mitigate both emissions and congestion issues, but the extent to which this innovation can be extended to a larger scale is not adequately addressed yet. The main question is therefore “What are the main explanatory factors of the scaling-up of the green shared transport niche in Amsterdam, in the context of societal transition?”. To answer this question, an extensive literature review was first conducted in order to identify the main theories dealing with transitions processes and niche markets, identified in Multi-Level Perspective, Strategic Niche Management and internal niche dynamics. These last two in particular provided a number of conditions to be assessed during the analysis, and a scoring criteria was established to determine the importance of those factors. Second, a methodological approach was developed in order to gather qualitative data from organisations operating in the green shared mobility domain in Amsterdam. The conditions identified within the theoretical approach were addressed to appraise the potential for the niche to scale-up. The main policy approaches aiming at promoting sustainable transport at local level were considered as well. After the coding process, the results were evaluated on the basis of stakeholder

Published
2017

46. Imaging assessment of portal venous system: pictorial essay of normal anatomy, anatomic variants and congenital anomalies

Author

Guerra, Alessandra, De Gaetano, Anna Maria, Infante, Amato, Mele, Caterina, Marini, M G, Rinninella, Emanuele, Inchingolo, R, Bonomo, Lorenzo, Guerra, A, De Gaetano, A (ORCID:0000-0002-7493-9462), Infante, A, Mele, C, Rinninella, E (ORCID:0000-0002-9165-2367), Bonomo, L (ORCID:0000-0001-5101-9367), Guerra, Alessandra, De Gaetano, Anna Maria, Infante, Amato, Mele, Caterina, Marini, M G, Rinninella, Emanuele, Inchingolo, R, Bonomo, Lorenzo, Guerra, A, De Gaetano, A (ORCID:0000-0002-7493-9462), Infante, A, Mele, C, Rinninella, E (ORCID:0000-0002-9165-2367), and Bonomo, L (ORCID:0000-0001-5101-9367)

Abstract

The purpose of this pictorial essay is to describe anatomic variants and congenital anomalies of portal venous system and related liver parenchymal alterations. The imaging findings of some of these entities have been previously described in other articles, however, this work encompasses all congenital anomalies of portal venous system with attention to their features on various imaging modalities; in particular we illustrated with detailed pictures all the main portal vein variants, congenital extra- and intra-hepatic porto-systemic venous shunts and portal vein aneurysm. Variants of portal branches and intrahepatic portosystemic shunts are quite uncommon, however, when present, they should be recognized before performing surgery or interventional procedures. Congenital absence of the portal vein is an important finding as the complete loss of portal perfusion predisposes the liver to focal or diffuse hyperplastic or dysplastic changes. Portal vein aneurysm is a rare clinical entity that can affect intraand extra-hepatic portal branches; although usually asymptomatic, thrombosis can occur. Awareness of congenital variants of portal venous system among radiologists should allow a more confident diagnosis and permit an accurate planning of surgical procedures and percutaneous interventions; identification of portal system anomalies also suggest an accurate evaluation of associated hepatic parenchymal anomalies such as nodular regenerative hyperplasia, focal nodular hyperplasia (FNH), and adenomas with high risk of malignant transformation

Published
2017

47. Care available to severely disabled older persons living at home in Florence, Italy

Author

Di Bari, M, Pecchioli, A, Mazzaglia, G, Marini, M, Maciocco, G, Ferrucci, L, Marchionni, N, Di Bari M, Pecchioli A, Mazzaglia G, Marini M, Maciocco G, Ferrucci L, Marchionni N, Di Bari, M, Pecchioli, A, Mazzaglia, G, Marini, M, Maciocco, G, Ferrucci, L, Marchionni, N, Di Bari M, Pecchioli A, Mazzaglia G, Marini M, Maciocco G, Ferrucci L, and Marchionni N

Abstract

Aims: To characterize the epidemiology of disability in, and the level of care available to, older community-dwellers in an Italian urban sample. Methods: In a 2-phase survey, persons aged 65+ years, randomly selected from the patients lists of 98 primary care physicians (PCP), were screened (phase I) by their PCP with a structured questionnaire to detect the presence of: 1) need of help in performing Basic and 2) Instrumental Activities of Daily Living (BADL, IADL); 3) poor vision or 4) hearing; 5)weight loss; 6) use of homecare services; 7) self-perceived inadequacy of income. Subjects reporting 2+ problems were further evaluated in face-to-face structured interviews (phase II), Results: Of 5445 participants, 597 (11%) screened positive in phase I and 416 were interviewed in phase II. Of these, 4, 29, 19 and 49% were disabled in 1-2 IADL, 3+ IADL, 1-2 BADL, and 3+ BADL. The extent of the support network increased with disability severity (p<0.01). The 274 participants with BADL disability received most of their help from close relatives (58.3 +/- 2.5%), followed by salaried assistants (20.5 +/- 2.1%), other relatives (19.5 +/- 1.9%), and public healthcare services (0.6 +/- 0.36%). Of the 397 care-givers interviewed, one-third were willing to institutionalize the older participants in case of further functional deterioration. This propensity was predicted only by a self-reported poor attitude towards caring. Conclusion: Many severely disabled older Italians receive care in their home by highly supportive family members. The level of assistance provided to them by public healthcare services is minimal.

Published
2008

48. Near zero fluoroscopic exposure during catheter ablation of supraventricular arrhythmias:the no-party multicentre randomized trial

Author

Casella, M. (Michela), Dello Russo, A. (Antonio), Pelargonio, G. (Gemma), Del Greco, M. (Maurizio), Zingarini, G. (Gianluca), Piacenti, M. (Marcello), Di Cori, A. (Andrea), Casula, V. (Victor), Marini, M. (Massimiliano), Pizzamiglio, F. (Francesca), Zucchetti, M. (Martina), Riva, S. (Stefania), Russo, E. (Eleonora), Narducci, M. L. (Maria Lucia), Soldati, E. (Ezio), Panchetti, L. (Luca), Startari, U. (Umberto), Bencardino, G. (Gianluigi), Perna, F. (Francesco), Santangeli, P. (Pasquale), Di Biase, L. (Luigi), Cichocki, F. (Fabrizio), Fattore, G. (Giovanni), Bongiorni, M. (Mariagrazia), Picano, E. (Eugenio), Natale, A. (Andrea), Tondo, C. (Claudio), Casella, M. (Michela), Dello Russo, A. (Antonio), Pelargonio, G. (Gemma), Del Greco, M. (Maurizio), Zingarini, G. (Gianluca), Piacenti, M. (Marcello), Di Cori, A. (Andrea), Casula, V. (Victor), Marini, M. (Massimiliano), Pizzamiglio, F. (Francesca), Zucchetti, M. (Martina), Riva, S. (Stefania), Russo, E. (Eleonora), Narducci, M. L. (Maria Lucia), Soldati, E. (Ezio), Panchetti, L. (Luca), Startari, U. (Umberto), Bencardino, G. (Gianluigi), Perna, F. (Francesco), Santangeli, P. (Pasquale), Di Biase, L. (Luigi), Cichocki, F. (Fabrizio), Fattore, G. (Giovanni), Bongiorni, M. (Mariagrazia), Picano, E. (Eugenio), Natale, A. (Andrea), and Tondo, C. (Claudio)

Abstract

Aims: Aim of this study was to compare a minimally fluoroscopic radiofrequency catheter ablation with conventional fluoroscopy-guided ablation for supraventricular tachycardias (SVTs) in terms of ionizing radiation exposure for patient and operator and to estimate patients’ lifetime attributable risks associated with such exposure. Methods and results: We performed a prospective, multicentre, randomized controlled trial in six electrophysiology (EP) laboratories in Italy. A total of 262 patients undergoing EP studies for SVT were randomized to perform a minimally fluoroscopic approach (MFA) procedure with the EnSiteTMNavXTM navigation system or a conventional approach (ConvA) procedure. The MFA was associated with a significant reduction in patients’ radiation dose (0 mSv, iqr 0–0.08 vs. 8.87 mSv, iqr 3.67–22.01; P < 0.00001), total fluoroscopy time (0 s, iqr 0–12 vs. 859 s, iqr 545–1346; P < 0.00001), and operator radiation dose (1.55 vs. 25.33 µS per procedure; P < 0.001). In the MFA group, X-ray was not used at all in 72% (96/134) of cases. The acute success and complication rates were not different between the two groups (P = ns). The reduction in patients’ exposure shows a 96% reduction in the estimated risks of cancer incidence and mortality and an important reduction in estimated years of life lost and years of life affected. Based on economic considerations, the benefits of MFA for patients and professionals are likely to justify its additional costs. Conclusion: This is the first multicentre randomized trial showing that a MFA in the ablation of SVTs dramatically reduces patients’ exposure, risks of cancer incidence and mortality, and years of life affected and lost, keeping safety and efficacy. Trial registration: clinicaltrials.gov Identifier: NCT01132274.

Published
2016

49. Position Statement on the management of continuous subcutaneous insulin infusion (CSII): The Italian Lazio experience

Author

Maurizi, A. R., Suraci, C., Pitocco, D., Schiaffini, R., Tubili, C., Morviducci, L., Giordano, R., Manfrini, S., Lauro, D., Frontoni, S., Pozzilli, P., Buzzetti, R., Bracaglia, D., Bloise, D., Cappa, M., Caputo, S., Cavallo, M. G., Chiaramonte, F., Ciampittiello, G., Cicconetti, E., Di Flaviani, A., Fava, D., Forte, E., Ghirlanda, G., Giaccari, A., Giuliano, M., Lauria Pantano, A., Leonetti, F., Leotta, S., Mancabitti, M. L., Marini, M. A., Napoli, A., Nardone, M. R., Patera, I. P., Piergiovanni, F., Pugliese, G., Spallone, V., Tatti, P., Tuccinardi, F., Ventura, C., Visalli, N., Pitocco D. (ORCID:0000-0002-6220-686X), Cappa M., Caputo S. (ORCID:0000-0003-0772-6800), Fava D., Forte E., Giaccari A. (ORCID:0000-0002-7462-7792), Leotta S., Napoli A., Pugliese G., Maurizi, A. R., Suraci, C., Pitocco, D., Schiaffini, R., Tubili, C., Morviducci, L., Giordano, R., Manfrini, S., Lauro, D., Frontoni, S., Pozzilli, P., Buzzetti, R., Bracaglia, D., Bloise, D., Cappa, M., Caputo, S., Cavallo, M. G., Chiaramonte, F., Ciampittiello, G., Cicconetti, E., Di Flaviani, A., Fava, D., Forte, E., Ghirlanda, G., Giaccari, A., Giuliano, M., Lauria Pantano, A., Leonetti, F., Leotta, S., Mancabitti, M. L., Marini, M. A., Napoli, A., Nardone, M. R., Patera, I. P., Piergiovanni, F., Pugliese, G., Spallone, V., Tatti, P., Tuccinardi, F., Ventura, C., Visalli, N., Pitocco D. (ORCID:0000-0002-6220-686X), Cappa M., Caputo S. (ORCID:0000-0003-0772-6800), Fava D., Forte E., Giaccari A. (ORCID:0000-0002-7462-7792), Leotta S., Napoli A., and Pugliese G.

Abstract

This document has been developed by a group of Italian diabetologists with extensive experience in continuous subcutaneous insulin infusion (CSII) therapy to provide indications for the clinical management of CSII in diabetic patients (both type 1 and type 2) based on delivery mode operating in Italy. Although the potential benefits of pump therapy in achieving glycemic goals is now accepted, such results cannot be obtained without specific knowledge and skills being conveyed to patients during ad hoc educational training. To ensure that these new technologies reach their full effectiveness, as demonstrated theoretically and clinically, a careful assessment of the overall therapeutic and educational process is required, in both qualitative and quantitative terms. Therefore, to ensure the cost-effectiveness of insulin pump therapy and to justify reimbursement of therapy costs by the National Health System in Italy, in this article we present a model for diabetes and healthcare centers to follow that provides for different levels of expertise in the field of CSII therapy. This model will guarantee the provision of excellent care during insulin pump therapies, thus representing the basis for a successful outcome and expansion of this form of insulin treatment in patients with diabetes while also keeping costs under control.

Published
2016

50. Development of the Olfactory Epithelium and Nasal Glands in TMEM16A-/- and TMEM16A+/+ Mice.

Author

Rock, Jason, Rock, Jason, Maurya, DK, Henriques, T, Marini, M, Pedemonte, N, Galietta, LJV, Rock, JR, Harfe, BD, Menini, A, Rock, Jason, Rock, Jason, Maurya, DK, Henriques, T, Marini, M, Pedemonte, N, Galietta, LJV, Rock, JR, Harfe, BD, and Menini, A

Abstract

TMEM16A/ANO1 is a calcium-activated chloride channel expressed in several types of epithelia and involved in various physiological processes, including proliferation and development. During mouse embryonic development, the expression of TMEM16A in the olfa

Published
2015

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