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5 results on '"Marchandeau, Stéphane"'

1. Parallel adaptation of rabbit populations to myxoma virus.

Author

Alves, Joel M, Alves, Joel M, Carneiro, Miguel, Cheng, Jade Y, Lemos de Matos, Ana, Rahman, Masmudur M, Loog, Liisa, Campos, Paula F, Wales, Nathan, Eriksson, Anders, Manica, Andrea, Strive, Tanja, Graham, Stephen C, Afonso, Sandra, Bell, Diana J, Belmont, Laura, Day, Jonathan P, Fuller, Susan J, Marchandeau, Stéphane, Palmer, William J, Queney, Guillaume, Surridge, Alison K, Vieira, Filipe G, McFadden, Grant, Nielsen, Rasmus, Gilbert, M Thomas P, Esteves, Pedro J, Ferrand, Nuno, Jiggins, Francis M, Alves, Joel M, Alves, Joel M, Carneiro, Miguel, Cheng, Jade Y, Lemos de Matos, Ana, Rahman, Masmudur M, Loog, Liisa, Campos, Paula F, Wales, Nathan, Eriksson, Anders, Manica, Andrea, Strive, Tanja, Graham, Stephen C, Afonso, Sandra, Bell, Diana J, Belmont, Laura, Day, Jonathan P, Fuller, Susan J, Marchandeau, Stéphane, Palmer, William J, Queney, Guillaume, Surridge, Alison K, Vieira, Filipe G, McFadden, Grant, Nielsen, Rasmus, Gilbert, M Thomas P, Esteves, Pedro J, Ferrand, Nuno, and Jiggins, Francis M

Abstract

In the 1950s the myxoma virus was released into European rabbit populations in Australia and Europe, decimating populations and resulting in the rapid evolution of resistance. We investigated the genetic basis of resistance by comparing the exomes of rabbits collected before and after the pandemic. We found a strong pattern of parallel evolution, with selection on standing genetic variation favoring the same alleles in Australia, France, and the United Kingdom. Many of these changes occurred in immunity-related genes, supporting a polygenic basis of resistance. We experimentally validated the role of several genes in viral replication and showed that selection acting on an interferon protein has increased the protein's antiviral effect.

Published
2019

2. Parallel adaptation of rabbit populations to myxoma virus.

Author

Alves, Joel M, Alves, Joel M, Carneiro, Miguel, Cheng, Jade Y, Lemos de Matos, Ana, Rahman, Masmudur M, Loog, Liisa, Campos, Paula F, Wales, Nathan, Eriksson, Anders, Manica, Andrea, Strive, Tanja, Graham, Stephen C, Afonso, Sandra, Bell, Diana J, Belmont, Laura, Day, Jonathan P, Fuller, Susan J, Marchandeau, Stéphane, Palmer, William J, Queney, Guillaume, Surridge, Alison K, Vieira, Filipe G, McFadden, Grant, Nielsen, Rasmus, Gilbert, M Thomas P, Esteves, Pedro J, Ferrand, Nuno, Jiggins, Francis M, Alves, Joel M, Alves, Joel M, Carneiro, Miguel, Cheng, Jade Y, Lemos de Matos, Ana, Rahman, Masmudur M, Loog, Liisa, Campos, Paula F, Wales, Nathan, Eriksson, Anders, Manica, Andrea, Strive, Tanja, Graham, Stephen C, Afonso, Sandra, Bell, Diana J, Belmont, Laura, Day, Jonathan P, Fuller, Susan J, Marchandeau, Stéphane, Palmer, William J, Queney, Guillaume, Surridge, Alison K, Vieira, Filipe G, McFadden, Grant, Nielsen, Rasmus, Gilbert, M Thomas P, Esteves, Pedro J, Ferrand, Nuno, and Jiggins, Francis M

Abstract

In the 1950s the myxoma virus was released into European rabbit populations in Australia and Europe, decimating populations and resulting in the rapid evolution of resistance. We investigated the genetic basis of resistance by comparing the exomes of rabbits collected before and after the pandemic. We found a strong pattern of parallel evolution, with selection on standing genetic variation favoring the same alleles in Australia, France, and the United Kingdom. Many of these changes occurred in immunity-related genes, supporting a polygenic basis of resistance. We experimentally validated the role of several genes in viral replication and showed that selection acting on an interferon protein has increased the protein's antiviral effect.

Published
2019

3. Parallel adaptation of rabbit populations to myxoma virus.

Author

Alves, Joel, Alves, Joel, Carneiro, Miguel, Cheng, Jade, Lemos de Matos, Ana, Rahman, Masmudur, Loog, Liisa, Campos, Paula, Wales, Nathan, Eriksson, Anders, Manica, Andrea, Strive, Tanja, Graham, Stephen, Afonso, Sandra, Bell, Diana, Belmont, Laura, Day, Jonathan, Fuller, Susan, Marchandeau, Stéphane, Palmer, William, Queney, Guillaume, Surridge, Alison, Vieira, Filipe, McFadden, Grant, Gilbert, M, Esteves, Pedro, Ferrand, Nuno, Jiggins, Francis, Nielsen, Rasmus, Alves, Joel, Alves, Joel, Carneiro, Miguel, Cheng, Jade, Lemos de Matos, Ana, Rahman, Masmudur, Loog, Liisa, Campos, Paula, Wales, Nathan, Eriksson, Anders, Manica, Andrea, Strive, Tanja, Graham, Stephen, Afonso, Sandra, Bell, Diana, Belmont, Laura, Day, Jonathan, Fuller, Susan, Marchandeau, Stéphane, Palmer, William, Queney, Guillaume, Surridge, Alison, Vieira, Filipe, McFadden, Grant, Gilbert, M, Esteves, Pedro, Ferrand, Nuno, Jiggins, Francis, and Nielsen, Rasmus

Abstract

In the 1950s the myxoma virus was released into European rabbit populations in Australia and Europe, decimating populations and resulting in the rapid evolution of resistance. We investigated the genetic basis of resistance by comparing the exomes of rabbits collected before and after the pandemic. We found a strong pattern of parallel evolution, with selection on standing genetic variation favoring the same alleles in Australia, France, and the United Kingdom. Many of these changes occurred in immunity-related genes, supporting a polygenic basis of resistance. We experimentally validated the role of several genes in viral replication and showed that selection acting on an interferon protein has increased the proteins antiviral effect.

Published
2019

4. Parallel adaptation of rabbit populations to myxoma virus

Author

Alves, Joel M., Carneiro, Miguel, Cheng, Jade Y., Matos, Ana Lemos de, Rahman, Masmudur M., Loog, Liisa, Campos, Paula F., Wales, Nathan, Eriksson, Anders, Manica, Andrea, Strive, Tanja, Graham, Stephen C., Afonso, Sandra, Bell, Diana J., Belmont, Laura, Day, Jonathan P., Fuller, Susan J., Marchandeau, Stéphane, Palmer, William J., Queney, Guillaume, Surridge, Alison K., Vieira, Filipe G., McFadden, Grant, Nielsen, Rasmus, Gilbert, M. Thomas P., Esteves, Pedro J., Ferrand, Nuno, Jiggins, Francis M., Alves, Joel M., Carneiro, Miguel, Cheng, Jade Y., Matos, Ana Lemos de, Rahman, Masmudur M., Loog, Liisa, Campos, Paula F., Wales, Nathan, Eriksson, Anders, Manica, Andrea, Strive, Tanja, Graham, Stephen C., Afonso, Sandra, Bell, Diana J., Belmont, Laura, Day, Jonathan P., Fuller, Susan J., Marchandeau, Stéphane, Palmer, William J., Queney, Guillaume, Surridge, Alison K., Vieira, Filipe G., McFadden, Grant, Nielsen, Rasmus, Gilbert, M. Thomas P., Esteves, Pedro J., Ferrand, Nuno, and Jiggins, Francis M.

Abstract

In the 1950s the myxoma virus was released into European rabbit populations in Australia and Europe, decimating populations and resulting in the rapid evolution of resistance. We investigated the genetic basis of resistance by comparing the exomes of rabbits collected before and after the pandemic. We found a strong pattern of parallel evolution, with selection on standing genetic variation favoring the same alleles in Australia, France and the United Kingdom. Many of these changes occurred in immunity-related genes, supporting a polygenic basis of resistance. We experimentally validated the role of several genes in viral replication and showed that selection acting on an interferon protein has increased its antiviral effect.

Published
2019

5. Proposal for a unified classification system and nomenclature of lagoviruses

Author

Agence Nationale de la Recherche (France), Région des Pays de la Loire, European Commission, Ministero della Salute, Swedish Research Council, Fundação para a Ciência e a Tecnologia (Portugal), Le Pendu, Jacques, Abrantes, Joana, Bertagnoli, Stéphane, Guitton, Jean-Sébastien, Le Gall-Reculé, Ghislaine, Lopes, Ana Margarida, Marchandeau, Stéphane, Alda, Fernando, Almeida, Tereza, Célio, Alves Paulo, Bárcena, Juan, Burmakina, Galina, Blanco, Esther, Calvete, Carlos, Cavadini, Patrizia, Cooke, Brian, Dalton, Kevin, Delibes Mateos, Miguel, Deptula, Wieslaw., Eden, John Sebastian, Wang, Fang, Ferreira, Catarina C., Ferreira, Paula, Foronda, Pilar, Gonçalves, David, Gavier-Widén, Dolores, Hall, Robin, Hukowska-Szematowicz, Beata, Kerr, Peter, Kovaliski, John, Lavazza, Antonio, Mahar, Jackie, Malogolovkin, Alexander, Marques, Raquel M., Marques, Sara, Martín-Alonso, Aaron, Monterroso, Pedro, Moreno, Sacramento, Mutze, Greg, Neimanis, Aleksija, Niedzwiedzka-Rystwej, Paulina, Peacock, David, Parra, Francisco, Rocchi, Mara, Rouco, Carlos, Ruvoën-Clouet, Nathalie, Silva, Eliane, Silvério, Diogo, Strive, Tanja, Thompson, Gertrudes, Tokarz-Deptula, Beata, Esteves, Pedro, Agence Nationale de la Recherche (France), Région des Pays de la Loire, European Commission, Ministero della Salute, Swedish Research Council, Fundação para a Ciência e a Tecnologia (Portugal), Le Pendu, Jacques, Abrantes, Joana, Bertagnoli, Stéphane, Guitton, Jean-Sébastien, Le Gall-Reculé, Ghislaine, Lopes, Ana Margarida, Marchandeau, Stéphane, Alda, Fernando, Almeida, Tereza, Célio, Alves Paulo, Bárcena, Juan, Burmakina, Galina, Blanco, Esther, Calvete, Carlos, Cavadini, Patrizia, Cooke, Brian, Dalton, Kevin, Delibes Mateos, Miguel, Deptula, Wieslaw., Eden, John Sebastian, Wang, Fang, Ferreira, Catarina C., Ferreira, Paula, Foronda, Pilar, Gonçalves, David, Gavier-Widén, Dolores, Hall, Robin, Hukowska-Szematowicz, Beata, Kerr, Peter, Kovaliski, John, Lavazza, Antonio, Mahar, Jackie, Malogolovkin, Alexander, Marques, Raquel M., Marques, Sara, Martín-Alonso, Aaron, Monterroso, Pedro, Moreno, Sacramento, Mutze, Greg, Neimanis, Aleksija, Niedzwiedzka-Rystwej, Paulina, Peacock, David, Parra, Francisco, Rocchi, Mara, Rouco, Carlos, Ruvoën-Clouet, Nathalie, Silva, Eliane, Silvério, Diogo, Strive, Tanja, Thompson, Gertrudes, Tokarz-Deptula, Beata, and Esteves, Pedro

Abstract

Lagoviruses belong to the Caliciviridae family. They were first recognized as highly pathogenic viruses of the European rabbit (Oryctolagus cuniculus) and European brown hare (Lepus europaeus) that emerged in the 1970–1980s, namely, rabbit haemorrhagic disease virus (RHDV) and European brown hare syndrome virus (EBHSV), according to the host species from which they had been first detected. However, the diversity of lagoviruses has recently expanded to include new related viruses with varying pathogenicity, geographic distribution and host ranges. Together with the frequent recombination observed amongst circulating viruses, there is a clear need to establish precise guidelines for classifying and naming lagovirus strains. Therefore, here we propose a new nomenclature based on phylogenetic relationships. In this new nomenclature, a single species of lagovirus would be recognized and called Lagovirus europaeus. The species would be divided into two genogroups that correspond to RHDV- and EBHSV-related viruses, respectively. Genogroups could be subdivided into genotypes, which could themselves be subdivided into phylogenetically well-supported variants. Based on available sequences, pairwise distance cutoffs have been defined, but with the accumulation of new sequences these cutoffs may need to be revised. We propose that an international working group could coordinate the nomenclature of lagoviruses and any proposals for revision.

Published
2017

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