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BACKGROUND: Novel noninvasive predictors of disease severity and prognosis in primary sclerosing cholangitis (PSC) are needed. This study evaluated the ability of extracellular matrix remodeling markers to diagnose fibrosis stage and predict PSC-related fibrosis progression and clinical events. METHODS: Liver histology and serum markers of collagen formation (propeptide of type III collagen [Pro-C3], propeptide of type IV collagen, propeptide of type V collagen), collagen degradation (type III collagen matrix metalloproteinase degradation product and type IV collagen matrix metalloproteinase degradation product), and fibrosis (enhanced liver fibrosis [ELF] score and its components [metalloproteinase-1, type III procollagen, hyaluronic acid]) were assessed in samples from baseline to week 96 in patients with PSC enrolled in a study evaluating simtuzumab (NCT01672853). Diagnostic performance for advanced fibrosis (Ishak stages 3-6) and cirrhosis (Ishak stages 5-6) was evaluated by logistic regression and AUROC. Prognostic performance for PSC-related clinical events and fibrosis progression was assessed by AUROC and Wilcoxon rank-sum test. RESULTS: Among 234 patients, 51% had advanced fibrosis and 11% had cirrhosis at baseline. Baseline Pro-C3 and ELF score and its components provided moderate diagnostic ability for discrimination of advanced fibrosis (AUROC 0.73-0.78) and cirrhosis (AUROC 0.73-0.81). Baseline Pro-C3, ELF score, and type III procollagen provided a moderate prognosis for PSC-related clinical events (AUROC 0.70-0.71). Among patients without cirrhosis at baseline, median changes in Pro-C3 and ELF score to week 96 were higher in those with than without progression to cirrhosis (both p < 0.001). CONCLUSIONS: Pro-C3 correlated with fibrosis stage, and Pro-C3 and ELF score provided discrimination of advanced fibrosis and cirrhosis and predicted PSC-related events and fibrosis progression. The results support the clinical utility of Pro-C3 and ELF score for

The observed energy spectra of accelerated particles at interplanetary shocks often do not match the diffusive shock acceleration (DSA) theory predictions. In some cases, the particle flux forms a plateau over a wide range of energies, extending upstream of the shock for up to seven flux's e-folds before submerging into the background spectrum. Remarkably, at and behind the shock that we have studied in detail, the flux falls off in energy as $\epsilon^{-1}$, consistent with the DSA prediction for a strong shock. The upstream plateau suggests a different particle transport mechanism than those traditionally employed in DSA models. We show that a standard (linear) DSA solution based on a widely accepted diffusive particle transport with an underlying resonant wave-particle interaction is inconsistent with the plateau in the particle flux. To resolve this contradiction, we modify the DSA theory in two ways. First, we include a dependence of the particle diffusivity $\kappa$ on the particle flux $F$ (nonlinear particle transport). Second, we invoke short-scale magnetic perturbations that are self-consistently generated by, but not resonant with, accelerated particles. They lead to the particle diffusivity increasing with the particle energy as $\propto\epsilon^{3/2}$ that simultaneously decreases with the particle flux as $1/F$. The combination of these two trends results in the flat spectrum upstream., Comment: 13 pages 3 figures 1 table

We present scientific program construction principles and a time allocation scheme developed for the World Space Observatory-Ultraviolet (WSO-UV) mission, which is an international space observatory for observation in UV spectral range 100-300 nm. The WSO-UV consists of a 1.7 m aperture telescope with instrumentation designed to carry out high resolution spectroscopy, long-slit low resolution spectroscopy and direct sky imaging. The WSO-UV Ground Segment is under development by Spain and Russia. They will coordinate the Mission and Science Operations and provide the satellite tracking stations for the project. The WSO-UV will work as a targeted scientific observatory. Three scientific programs will be carried out at the observatory. Core Program of scientific observations, which deserves large amounts of observing time, will be defined by the WSO-UV Science Committee to allow the conduction of high impact or legacy scientific projects. Funding Bodies Program is the guaranteed time granted to each one of the national bodies funding the WSO-UV project. Guest observer program for everyone, or Open Program, consists of astronomical observations obtained with the WSO-UV by astronomers who may or may not belong to the WSO-UV international consortium. It is open to excellent scientific projects from the world-wide community and occupies up to 40% of total observational time. Apart from the particularities associated to a science mission, this new mission will be affected by a new concept of observations management, trying to maximize the scientific return of this mission, and the shared operations between the two sites located in Spain and Russia. A brief summary of the algorithmic strategies analyzed for scheduling optimization is also given in the paper., Unidad Deptal. de Astronomía y Geodesia, Fac. de Ciencias Matemáticas, TRUE, pub

The World Space Observatory Ultraviolet (WSOUV)is the space mission that will grant access to the ultraviolet (UV) range in the post Hubble epoch. WSO-UV is equipped with instrumentation for imaging and spectroscopy and it is fully devoted to UV astronomy. In this article, we outline the WSO-UV mission model and present the current status of the project., Unidad Deptal. de Astronomía y Geodesia, Fac. de Ciencias Matemáticas, TRUE, pub

Repeats in nucleotide sequences are connected with various genome characteristics. RNA secondary structures are related to repeats at the primary structure level. Four different types of nucleotide repeats may be identified: direct non-complementary, direct complementary, inverse non-complementary and inverse complementary. Reverse complementary tandem repeats, for example, may form hairpin secondary structures, while reverse non-complementary may be recognized by proteins. On the other side, direct complementary and/or non-complementary repeats may be reflected in protein sequence repeats, if found in the same reading frame, within the protein-coding sequence. Here we analyzed (determined and compared) all four types of nucleotide repeats in referent sequences of SARS-CoV-1, SARS-CoV-2 and MERS-COV viruses. In addition to the complete repeat set, we analyze different repeat subsets: repeats with the left component within the 5’ end, repeats with the right component within the 3’ end, and repeats with at least one component within the surface glycoprotein coding sequence. We found significant differences in repeat sets corresponding to analyzed sequences in all analyzed repeat sets. In this moment we can only speculate what are the real consequences of the discovered differences

We have completed our observational program to search for wide binary systems with non-coeval components in the southern sky and report our results here. The final set of four systems was spectroscopically investigated in this paper. No binary systems with components of different ages were found among them. Taking into account our previous studies, we estimate the fraction of such binaries (i.e., binaries formed, presumably, by capture) not higher than 0.06~\%. The study will be continued on the northern sky., Comment: 9 pages, 3 figures, 2 tables. Published in Research in Astronomy and Astrophysics

The existence of a large number of sequenced SARS-COV-2 isolates provides an opportunity to observe genomic variability in a massive sample. The goal of our research was to use data mining techniques to study possible correlation between codon usage and classification by WHO-labels in a certain period of time. The material includes 745,533 isolates with 12,236,672 coding sequences (proteins) from NCBI (10.08.2022.). RSCU was used as a measure of codon usage. Samples are associated with WHO-labels (based on Pango_Id) and time intervals. Inconsistency of WHO-labels with periods in which the respective strains were actually present was observed. The isolates with the observed discrepancy were excluded from the sample. Isolates without assigned WHO-labels were also excluded. In addition, individual coding sequences containing ambiguous nucleotide codes were eliminated. Clustering was performed for each of the 12 common types of coding sequences (proteins), with multiple methods and a different number of clusters. Neural clustering gave the best results. For different protein types, different degrees of RSCU variability are observed. In the case of proteins with a small variation in nucleotide contents, over 95% of the material belongs to a single cluster, while the other clusters are of negligible size. In the case of proteins with more variations, a higher number of pure clusters (by WHO-labels) is obtained, with a small number of heterogeneous clusters (about 10% of the material). In those heterogeneous clusters, there are isolates with different WHOlabels that were present in parallel at some point, as a kind of transitional forms between two strains. Different classification models were created on the same sample. Models based on protein types with higher diversity between coding sequences are highly accurate (96- 100%). Using the classification models, the corresponding WHO-labels were associated with isolates without previously assigned WHO-labels.

The Covid-19 pandemic escalated demand for scientific explanations and guidance, creating opportunities for scientists to become publicly visible. In this study, we compared characteristics of visible scientists during the first year of the Covid-19 pandemic (January to December 2020) across 16 countries. We find that the scientists who became visible largely matched socio-cultural criteria that have characterised visible scientists in the past (e.g., age, gender, credibility, public image, involvement in controversies). However, there were limited tendencies that scientists commented outside their areas of expertise. We conclude that the unusual circumstances created by Covid-19 did not change the phenomenon of visible scientists in significant ways.

Recent measurements of primary and secondary CR spectra, their arrival directions, and our improved knowledge of the magnetic field geometry around the heliosphere allow us to set a bound on the distance beyond which a puzzling 10-TeV "bump" cannot originate. The sharpness of the spectral breaks associated with the bump, the abrupt change of the CR intensity across the local magnetic equator ($90^{\circ}$ pitch angle), and the similarity between the primary and secondary CR spectral patterns point to a local reacceleration of the bump particles out of the background CRs. We argue that a nearby shock may generate such a bump by increasing the rigidity of the preexisting CRs below 50 TV by a mere factor of ~1.5. Reaccelerated particles below ~0.5 TV are convected with the interstellar medium flow and do not reach the Sun, thus creating the bump. This single universal process is responsible for the observed spectra of all CR species in the rigidity range below 100 TV. We propose that one viable candidate is the system of shocks associated with Epsilon Eridani star at 3.2 pc of the Sun, which is well aligned with the direction of the local magnetic field. Other shocks, such as old supernova shells, may produce a similar effect. We provide a simple formula that reproduces the spectra of all CR species with only three parameters uniquely derived from the CR proton data. We show how our formalism predicts helium and carbon spectra and the B/C ratio., Comment: 8 pages ICRC 2023 conf. #143

Gaia Data Release 3 (DR3) provides extensive information on the astrophysical properties of stars, such as effective temperature, surface gravity, metallicity, and luminosity, for over 470 million objects. However, as Gaia's stellar parameters in GSP-Phot module are derived through model-dependent methods and indirect measurements, it can lead to additional systematic errors in the derived parameters. In this study, we compare GSP-Phot effective temperature estimates with two high-resolution and high signal-to-noise spectroscopic catalogues: APOGEE DR17 and GALAH DR3, aiming to assess the reliability of Gaia's temperatures. We introduce an approach to distinguish good-quality Gaia DR3 effective temperatures using machine-learning methods such as XGBoost, CatBoost and LightGBM. The models create quality flags, which can help one to distinguish good-quality GSP-Phot effective temperatures. We test our models on three independent datasets, including PASTEL, a compilation of spectroscopically derived stellar parameters from different high-resolution studies. The results of the test suggest that with these models it is possible to filter effective temperatures as accurate as 250 K with ~ 90 per cent precision even in complex regions, such as the Galactic plane. Consequently, the models developed herein offer a valuable quality assessment tool for GSP-Phot effective temperatures in Gaia DR3. Consequently, the developed models offer a valuable quality assessment tool for GSP-Phot effective temperatures in Gaia DR3. The dataset with flags for all GSP-Phot effective temperature estimates, is publicly available, as are the models themselves., Comment: 13 pages, 10 figures

The nanofine spatial dissipative structures (NSDS) were characterized by transmission electron microscopy and electron diffraction. The NSDS obtained by thermogradiently processing an amorphous selenium film by unilateral heating of its lower surface at T = 413 K preliminarily. The results indicate that the NSDS of hexagonal selenium obtained in an amorphous film possess an azimuthal curvature of the lattice and a nonlinear fan-shaped system of flexural contours on their electron microscopic image. The lattice of the above NSDS undergoes elastic - plastic rotational curvature around three mutually perpendicular directions. The lattice rotation angles of hexagonal selenium NSDS reach: around [001], - 25 , around the direction perpendicular [001] and lying in the plane of the amorphous film - 32 , around the direction perpendicular to the first two ones and not lying in the plane of the amorphous film - azimuthal curvature of the lattice, - 35 . Thus, as a result of electron-microscopic and microdiffraction studies, it was found that NSDS of hexagonal selenium with azimuthal curvature of the lattice, causing the curvature of its habitus, are in a nonequilibrium state. © Published under licence by IOP Publishing Ltd.

Nanofine rhomboid spatial dissipative structures (NRSDS) of hexagonal selenium were found and studied by means of transmission electron microscopy in amorphous Se films coated with nanofine layers of amorphous carbon, at a temperature of their thermo gradient treatment of 423 K. As a result, pictures were received of fan-shaped linear bending extinction contours on the electron-microscopic images of NRSDS. It was shown that in the above NRSDS take place continuous linear increase in the bend radius of the lattice along [001], due to continuous linear relaxation of the inhomogeneous elastic torsion of the lattice around [001]. The continuous linear relaxation of the elastic rotational curvature of the lattice around [001] in NRSDS of hexagonal selenium with inhomogeneous elastic rotational curvature of the lattice covers the entire nanofine rhomboid spatial dissipative structures, and not its part, as is the case with the formation of interblock boundaries in the nanofine rhomboid spatial dissipative structures. © Published under licence by IOP Publishing Ltd.

Two-dimensional geometric object "neutral surface"- successfully used to study thin plates. The use of this two-dimensional geometric object is not possible for the study of physical properties and physical processes in nano-thin SDS (spatial dissipative structures). The SDS lattice undergoes a rotational curvature around three mutually perpendicular directions, and the nano-thin SDS itself remains flat. We have developed a method for the study of nano-thin SDS with rotary lattice curvature. We used as a basis the method of visualizing the rotational curvature of the lattice by constructing a two-dimensional geometric object - the surface of the lattice curvature by nano-thin SDS. This method of investigation involves application of the lattice curvature surface with nano-thin SDS for the selected crystallographic direction as a "neutral surface". The method will find application in nanotechnology. © Published under licence by IOP Publishing Ltd.

In 1945, E. Schrödinger predicted the possibility of the existence of "aperiodic crystals,"that is, more and more increasing crystalline aggregates, but without a simple lattice repetition mechanism. In the present work, such structures are experimentally prepared using selenium as an example. By thermal gradient treatment of the amorphous selenium film, we have obtained nano-thin spatial dissipative structures (SDS) of hexagonal selenium, the lattice of which undergoes non-uniform rotational curvature around, in the general case, three mutually perpendicular directions. The formation of these nano-thin SDS of hexagonal selenium occurs as a result of cooperative rotations of selenium macromolecules around, in general, three mutually perpendicular directions. Since nano-thin SDS after hardening in air have all the features of crystals each of the above nano-thin SDS of hexagonal selenium obtained at different annealing temperatures corresponds to the concept of "aperiodic crystals"Thus, "aperiodic crystals"were obtained experimentally, the possibility of the existence of which was predicted by E. Schrödinger. © Published under licence by IOP Publishing Ltd.

The nanofine spatial dissipative structures (NSDS) were characterized by transmission electron microscopy and electron diffraction. The NSDS obtained by thermogradiently processing an amorphous selenium film by unilateral heating of its lower surface at T = 413 K preliminarily. The results indicate that the NSDS of hexagonal selenium obtained in an amorphous film possess an azimuthal curvature of the lattice and a nonlinear fan-shaped system of flexural contours on their electron microscopic image. The lattice of the above NSDS undergoes elastic - plastic rotational curvature around three mutually perpendicular directions. The lattice rotation angles of hexagonal selenium NSDS reach: around [001], - 25 , around the direction perpendicular [001] and lying in the plane of the amorphous film - 32 , around the direction perpendicular to the first two ones and not lying in the plane of the amorphous film - azimuthal curvature of the lattice, - 35 . Thus, as a result of electron-microscopic and microdiffraction studies, it was found that NSDS of hexagonal selenium with azimuthal curvature of the lattice, causing the curvature of its habitus, are in a nonequilibrium state. © Published under licence by IOP Publishing Ltd.

Nanofine rhomboid spatial dissipative structures (NRSDS) of hexagonal selenium were found and studied by means of transmission electron microscopy in amorphous Se films coated with nanofine layers of amorphous carbon, at a temperature of their thermo gradient treatment of 423 K. As a result, pictures were received of fan-shaped linear bending extinction contours on the electron-microscopic images of NRSDS. It was shown that in the above NRSDS take place continuous linear increase in the bend radius of the lattice along [001], due to continuous linear relaxation of the inhomogeneous elastic torsion of the lattice around [001]. The continuous linear relaxation of the elastic rotational curvature of the lattice around [001] in NRSDS of hexagonal selenium with inhomogeneous elastic rotational curvature of the lattice covers the entire nanofine rhomboid spatial dissipative structures, and not its part, as is the case with the formation of interblock boundaries in the nanofine rhomboid spatial dissipative structures. © Published under licence by IOP Publishing Ltd.

Two model calculations which elucidate the basic physics of zonal flow generation are presented. The first uses statistical ray optics to clarify the physics of the modulational instability process. The second uses the envelope formalism to obtain and solve a simple system of equations for the zonal flow and drift wave envelope. This simple system is closely analogous to the Zakharov equations for Langmuir turbulence.

We report a simple and convenient approach to the one-pot synthesis of hyperbranched polyurethane-triazoles with desirable properties. This method is based on in situ generation of an AB(2) + A(2) + B-4 azide-acetylene monomer mixture of known composition, due to quantitative reactions of urethane formation between isophorone diisocyanate (IPDI), 1,3-diazidopropanol-2 (DAPOL) (in the first stage) and propargyl alcohol (in the second stage). The obtained monomer mixture can be involved in step-growth polymerization by azide-alkyne cycloaddition without additional purification (in the third stage). The properties of the resulting polymers should depend on the composition of the monomer mixture. Therefore, first the model revealing the correlation between the monomer composition and the ratio and reactivity of the IPDI and DAPOL active groups is developed and proven. In addition, the newly developed structural kinetic model considering the substitution effect at polyaddition of the complex mixture of monomers allows the prediction of the degree of branching of the target polymer. Based on our calculations, the hyperbranched polyurethane-triazoles were synthesized under found conditions. All products were characterized by H-1 NMR, FTIR, SEC, DLS, DSC, TGA and viscometry methods. It was shown that the degree of branching, molecular weight, intrinsic viscosity, and hydrodynamic radius of the final hyperbranched polymers can be specified at the first stage of one-pot synthesis. The obtained hyperbranched polyurethane-triazoles showed a degree of branching from 0.21 to 0.44 (calculated DB-0.25 and 0.45, respectively)., QC 20221130

State-of-the-art face recognition systems require vast amounts of labeled training data. Given the priority of privacy in face recognition applications, the data is limited to celebrity web crawls, which have issues such as limited numbers of identities. On the other hand, self-supervised revolution in the industry motivates research on the adaptation of related techniques to facial recognition. One of the most popular practical tricks is to augment the dataset by the samples drawn from generative models while preserving the identity. We show that a simple approach based on fine-tuning pSp encoder for StyleGAN allows us to improve upon the state-of-the-art facial recognition and performs better compared to training on synthetic face identities. We also collect large-scale unlabeled datasets with controllable ethnic constitution -- AfricanFaceSet-5M (5 million images of different people) and AsianFaceSet-3M (3 million images of different people) -- and we show that pretraining on each of them improves recognition of the respective ethnicities (as well as others), while combining all unlabeled datasets results in the biggest performance increase. Our self-supervised strategy is the most useful with limited amounts of labeled training data, which can be beneficial for more tailored face recognition tasks and when facing privacy concerns. Evaluation is based on a standard RFW dataset and a new large-scale RB-WebFace benchmark. The code and data are made publicly available at https://github.com/seva100/stylegan-for-facerec., Comment: 16 pages, 9 figures, 11 tables; accepted to ICCV 2023

Pre-trained language models (PLMs) are fundamental for natural language processing applications. Most existing PLMs are not tailored to the noisy user-generated text on social media, and the pre-training does not factor in the valuable social engagement logs available in a social network. We present TwHIN-BERT, a multilingual language model productionized at Twitter, trained on in-domain data from the popular social network. TwHIN-BERT differs from prior pre-trained language models as it is trained with not only text-based self-supervision, but also with a social objective based on the rich social engagements within a Twitter heterogeneous information network (TwHIN). Our model is trained on 7 billion tweets covering over 100 distinct languages, providing a valuable representation to model short, noisy, user-generated text. We evaluate our model on various multilingual social recommendation and semantic understanding tasks and demonstrate significant metric improvement over established pre-trained language models. We open-source TwHIN-BERT and our curated hashtag prediction and social engagement benchmark datasets to the research community.

The production of the artificial 51Cr neutrino source with activity > 3 MCi for the experiment BEST is presented. This procedure consisted of making a 50Cr target and irradiating it with thermal neutrons in a nuclear reactor SM-3. The production of a target in the form of disks with a thickness of 4 mm and a diameter of 84 and 88 mm included enrichment (to 96.5% in 50Cr) of natural chromium in the form of oxyfluoride by gas centrifugation, electrolytic reduction and refining of metallic chromium, as well as the formation of chromium disks by spark plasma sintering. Simulations of various source geometries, neutron flux and nuclear transmutation were carried out to validate the design of the source, the irradiation device and the transport container, the required chemical purity of the target and the irradiation schedule in the reactor. The calculated activity of the source after 75 effective days of irradiation was 3.55 MCi. The activity of the source was measured by the calorimetric method and amounted to 3.41 MCi at the time of its delivery to the Baksan Neutrino Observatory. This is the most intense chemically pure neutrino source ever produced., Comment: 18 pages, 8 figures

Social networks, such as Twitter, form a heterogeneous information network (HIN) where nodes represent domain entities (e.g., user, content, advertiser, etc.) and edges represent one of many entity interactions (e.g, a user re-sharing content or "following" another). Interactions from multiple relation types can encode valuable information about social network entities not fully captured by a single relation; for instance, a user's preference for accounts to follow may depend on both user-content engagement interactions and the other users they follow. In this work, we investigate knowledge-graph embeddings for entities in the Twitter HIN (TwHIN); we show that these pretrained representations yield significant offline and online improvement for a diverse range of downstream recommendation and classification tasks: personalized ads rankings, account follow-recommendation, offensive content detection, and search ranking. We discuss design choices and practical challenges of deploying industry-scale HIN embeddings, including compressing them to reduce end-to-end model latency and handling parameter drift across versions.

A shock wave propagating perpendicularly to an ambient magnetic field accelerates particles considerably faster than in the parallel propagation regime. However, the perpendicular acceleration stops after the shock overruns a circular particle orbit. At the same time, it may continue in flows resulting from supersonically colliding plasmas bound by a pair of perpendicular shocks. Although the double-shock acceleration mechanism, which we consider in detail, is not advantageous for thermal particles, pre-energized particles may avoid the premature end of acceleration. We argue that if their gyroradius exceeds the dominant turbulence scale between the shocks, these particles might traverse the intershock space repeatedly before being carried away by the shocked plasma. Moreover, entering the space between the shocks of similar velocities $u_{1}\approx u_{2}\approx c$, such particles start bouncing between the shocks at a fixed angle $\approx 35.3^{\circ}$ to the shock surface. Their drift along the shock fronts is slow, $V_{d}\sim\left|u_{2}-u_{1}\right|\ll c$, so that it will take $N\sim Lc/\left|u_{2}-u_{1}\right|d\gg1$ bounces before they escape the accelerator (here, $L$ is the size of the shocks and $d$ is the gap between them). Since these particles more than ten-fold their energy per cycle (two consecutive bounces), we invoke other possible losses that can limit the acceleration. They include drifts due to rippled shocks, the nonparallel mutual orientation of the upstream magnetic fields, and radiative losses., Comment: 21 pages, 13 figure, improved in V.2

In this paper, we investigate the orbital and stellar parameters of low- and intermediate-mass close binary systems. We use models, presented in the catalogue of (Han et al. 2000) and calculate parameters of accretors. We also construct distributions of systems along luminosity, semi-major axis and angular momentum, and make some conclusions on their evolution with time. We made a comparison of the results with observational data and it shows a good agreement. The set of theoretical models published in (Han et al. 2000) quite adequately describes the observational data and, consequently, can be used to determine the evolutionary path of specific close binary systems, their initial parameters values and final stages., Comment: 13 pages, 7 figures

We have estimated masses of components of visual binaries from their spectral classification. We have selected pairs, where the less massive component looks more evolved. Spectral observations of some of such pairs were made, and at least one pair, HD~156331, was confirmed to have components of different age. Since mass exchange is excluded in wide binaries, it means that HD~156331 can be formed by the capture., Comment: 6 pages, 2 figures. accepted to Open Astronomy

3350 objects from the Sixth catalog of orbits of visual binary stars (ORB6) are investigated to validate Gaia EDR3 parallaxes and provide mass estimates for the systems. We show that 2/3 of binaries with 0.2 - 0.5 arcsec separation are left without a parallax solution in EDR3. A special attention is paid to 521 pairs with parallax known separately for both components. We find 16 entries that are deemed to be chance alignments of unrelated stars. At once we show examples of high-confidence binary systems with significant differences in the reported parallaxes of their components. Next we conclude that the reported Gaia EDR3 parallax errors are underestimated, at least by a factor of 3 for sources with large RUWE. Parallaxes are needed to estimate stellar masses. Since nearly 30\% of ORB6 entries lack 5 or 6-parameter solution in EDR3, we attempt to enrich the astrometric data. Distant companions of ORB6 entries are revealed in EDR3 by analysis of stellar proper motions and Hipparcos parallaxes. Notably, in 28 cases intrinsic EDR3 parallaxes of the binary components appear to be less reliable than the parallax of the outer companions. Gaia DR2, TGAS and Hipparcos parallaxes are used when EDR3 data is unavailable. Synthetic mass-luminosity relation in the G band for main sequence stars is obtained to provide mass estimates along with dynamical masses calculated via Kepler's Third Law., Comment: Accepted for publication in MNRAS 28.09.2022, 15 pages, 11 figures

We have analyzed the retrieval of the relation between mass and absolute Gaia G magnitude as obtained from theoretical models by \cite{2012MNRAS.427..127B} for the stars of different luminosity classes. For subgiant and main-sequence stars, we provide approximate analytical direct and inverse relations based on the most probable value of G magnitude in the course of evolution within the given stage. A comparison with (albeit few) observational data confirms that our results can be used for the estimation of the stellar mass from Gaia photometry in the range of 1 to 10 solar mass. We argue that similar relations for other luminosity classes are not informative., Comment: 5 pages, 3 figures

A two-field model of potential vorticity (PV) staircase structure and dynamics relevant to both beta-plane and drift-wave plasma turbulence is studied numerically and analytically. The model evolves averaged PV whose flux is both driven by and regulates, a potential enstrophy field, $\varepsilon$. The model employs a closure using a mixing length model. Its link to bistability, vital to staircase generation, is analyzed and verified by integrating the equations numerically. Long-time staircase evolution consistently manifests a pattern of meta-stable quasi-periodic configurations, lasting for hundreds of time units, yet interspersed with abrupt ($\Delta t\ll1$) mergers of adjacent steps in the staircase. The mergers occur at the staircase lattice defects where the pattern has not completely relaxed to a strictly periodic solution that can be obtained analytically. Other types of stationary solutions are solitons and kinks in the PV gradient and $\varepsilon$ - profiles. The waiting time between mergers increases strongly as the number of steps in the staircase decreases. This is because of an exponential decrease in inter-step coupling strength with growing spacing. The long-time staircase dynamics is shown numerically be determined by local interaction with adjacent steps. Mergers reveal themselves through the explosive growth of the turbulent PV-flux which, however, abruptly drops to its global constant value once the merger is completed.

A two-field model of potential vorticity (PV) staircase structure and dynamics relevant to both beta-plane and drift-wave plasma turbulence is studied numerically and analytically. The model evolves averaged PV whose flux is both driven by and regulates, a potential enstrophy field, $\varepsilon$. The model employs a closure using a mixing length model. Its link to bistability, vital to staircase generation, is analyzed and verified by integrating the equations numerically. Long-time staircase evolution consistently manifests a pattern of meta-stable quasi-periodic configurations, lasting for hundreds of time units, yet interspersed with abrupt ($\Delta t\ll1$) mergers of adjacent steps in the staircase. The mergers occur at the staircase lattice defects where the pattern has not completely relaxed to a strictly periodic solution that can be obtained analytically. Other types of stationary solutions are solitons and kinks in the PV gradient and $\varepsilon$ - profiles. The waiting time between mergers increases strongly as the number of steps in the staircase decreases. This is because of an exponential decrease in inter-step coupling strength with growing spacing. The long-time staircase dynamics is shown numerically be determined by local interaction with adjacent steps. Mergers reveal themselves through the explosive growth of the turbulent PV-flux which, however, abruptly drops to its global constant value once the merger is completed.

Two model calculations which elucidate the basic physics of zonal flow generation are presented. The first uses statistical ray optics to clarify the physics of the modulational instability process. The second uses the envelope formalism to obtain and solve a simple system of equations for the zonal flow and drift wave envelope. This simple system is closely analogous to the Zakharov equations for Langmuir turbulence.

We determine the interstellar extinction in the selected high-latitude areas of the sky based on Gaia EDR3 astrometry and photometry and spectroscopic data from RAVE survey. We approximate the results with the cosecant law in each area thus deriving the parameters of the barometric formula for different lines of sight. The distribution of the parameters over the entire sky is described using spherical harmonics. As a result, we get a mathematical description of the interstellar visual extinction for different lines of sight and distances from the Sun which can be used for estimating interstellar extinction., Comment: 11 pages, 6 figures

Significant progress in cosmic ray (CR) studies was achieved over the past decade. Particularly important are precise measurements of primary and secondary species in the TV rigidity domain that show a bump in the spectra of CR species from 0.5-50 TV. In this letter, we argue that it is likely caused by a stellar bow- or wind-termination shock that reaccelerates preexisting CRs, which further propagate to the Sun along the magnetic field lines. This single universal process is responsible for the observed spectra of all CR species in the rigidity range below 100 TV. A viable candidate is Epsilon Eridani star at 3.2 pc from the Sun, which is well-aligned with the direction of the local magnetic field. We provide a simple formula that reproduces the spectra of all CR species with only two nonadjustable shock parameters, uniquely derived from the proton data. We show how our formalism predicts helium and carbon spectra and the B/C ratio., Comment: 5 pages, 4 figures, submitted to PRL

The distribution of visual interstellar extinction $A_V$ has been mapped in selected areas over the Northern sky, using available LAMOST DR5 and Gaia DR2/EDR3 data. $A_V$ was modelled as a barometric function of galactic latitude and distance. The function parameters were then approximated by spherical harmonics. The resulting analytical tridimensional model of the interstellar extinction can be used to predict $A_V$ values for stars with known parallaxes, as well as the total Galactic extinction in a given location in the sky., Comment: 18 pages, 33 figures, accepted by EPJ

Selection of extreme objects in the data from large-scale sky surveys is a powerful tool for the detection of new classes of astrophysical objects or rare stages of their evolution. The cross-matching of catalogues and analysis of the color indices of their objects is a usual approach for this problem which has already provided a lot of interesting results. However, the analysis of objects that are found in only one of the surveys, and absent in all others, should also attract close attention, as it may lead to the discovery of both transients and objects with extreme color values. Here we report on the initial study aimed at the detection of objects with a significant UV excess in their spectra by cross-matching of the GALEX all-sky catalogue with several other surveys in different wavelength ranges and analyzing the ones visible in GALEX only, or having extreme UV to optical colors (ultraviolet luminous objects). We describe the methodology for such investigation, explain the selection of surveys for this study, and show the initial results based on the search in a small fraction of the sky. We uncovered several prominent UV-only objects lacking the counterparts in the catalogues of longer wavelengths, and discuss their possible nature. We also detected a single source showing an extreme UV to optical color and corresponding to UV flare on a cool sdM subdwarf star. Finally, we discuss the possible populations of objects that may be revealed in a future larger-scale analysis of this kind., Comment: 8 pages, 7 figures, 3 tables. Accepted to MNRAS

Aims Hypothesis: Personality Disorder (PD) adolescents, compared to non-PD case, have a worse experience at transition. Aims: To describe the outcomes of referrals of adolescents for transition to adult services and compare PD and non-PD populations to identify potential improvements to allow for better transition experience of the PD patients. Background Borderline PD is prevalent in adolescents - although there is a reluctance to make the diagnosis. When patients reach graduation from CAMHS, many fall through the ‘gap’ in services during the transition. Consequently, adding the paucity in research about the transition experience of PD patients, it is important to evaluate what happens to these patients during the transition process to help better understand their experience, and how it can be improved. Method Patient's clinical records from Tower Hamlet CAMHS, East London NHS Foundation Trust, were reviewed retrospectively from July 2018 to November 2019, assessing whether optimal transition standards were met. A total of 41 cases that transitioned from CAMHS to AMHS were identified. Transition standards compared were: information sharing – case and risk, parallel care, transition planning and continuity. PD diagnosis was identified based on the recording of this diagnosis or meeting DSM5 criteria from the notes. PD and non-PD transition experience was compared. Result 36 were given a diagnosis by the CAMHS clinician at transition and 5 had no diagnosis assigned. No cases had a PD diagnosis made by the CAMHS clinician, however 1 case mentioned ‘PD traits’, 1 mentioned ‘EUPD’ as a possible differential and 2 cases were labelled as ‘emotional dysregulation’. The research team found 17 cases that met DSM5 criteria for PD diagnosis. Comparing transition experience of PD vs non-PD patients, the PD patients had a less optimal transition process. Statistical analysis using Chi Square Tests, showed significantly less optimal transition planning (X2 = 5.103, p < 0.05) a

We determine the interstellar extinction in the selected high-latitude areas of the sky based on Gaia EDR3 astrometry and photometry and spectroscopic data from RAVE survey. We approximate the results with the cosecant law in each area thus deriving the parameters of the barometric formula for different lines of sight. The distribution of the parameters over the entire sky is described using spherical harmonics. As a result, we get a mathematical description of the interstellar visual extinction for different lines of sight and distances from the Sun which can be used for estimating interstellar extinction., Comment: 11 pages, 6 figures

The distribution of visual interstellar extinction $A_V$ has been mapped in selected areas over the Northern sky, using available LAMOST DR5 and Gaia DR2/EDR3 data. $A_V$ was modelled as a barometric function of galactic latitude and distance. The function parameters were then approximated by spherical harmonics. The resulting analytical tridimensional model of the interstellar extinction can be used to predict $A_V$ values for stars with known parallaxes, as well as the total Galactic extinction in a given location in the sky., Comment: 18 pages, 33 figures, accepted by EPJ

Recent precise measurements of primary and secondary cosmic rays (CRs) in the TV rigidity domain have unveiled a bump in their spectra, located between 0.5-50 TV. We argue that a local shock may generate such a bump by increasing the rigidity of the preexisting CRs below 50 TV by a mere factor of ~1.5. Reaccelerated particles below ~0.5 TV are convected with the interstellar medium (ISM) flow and do not reach the Sun, thus creating the bump. This single universal process is responsible for the observed spectra of all CR species in the rigidity range below 100 TV. We propose that one viable shock candidate is the Epsilon Eridani star at 3.2 pc from the Sun, which is well-aligned with the direction of the local magnetic field. Other shocks, such as old supernova shells, may produce a similar effect. We provide a simple formula, Eq. (9), that reproduces the spectra of all CR species with only two nonadjustable shock parameters, uniquely derived from the proton data. We show how our formalism predicts helium and carbon spectra and the B/C ratio., Comment: 12 pages, 7 figures, 2 tables, ApJ in press

Selection of extreme objects in the data from large-scale sky surveys is a powerful tool for the detection of new classes of astrophysical objects or rare stages of their evolution. The cross-matching of catalogues and analysis of the color indices of their objects is a usual approach for this problem which has already provided a lot of interesting results. However, the analysis of objects that are found in only one of the surveys, and absent in all others, should also attract close attention, as it may lead to the discovery of both transients and objects with extreme color values. Here we report on the initial study aimed at the detection of objects with a significant UV excess in their spectra by cross-matching of the GALEX all-sky catalogue with several other surveys in different wavelength ranges and analyzing the ones visible in GALEX only, or having extreme UV to optical colors (ultraviolet luminous objects). We describe the methodology for such investigation, explain the selection of surveys for this study, and show the initial results based on the search in a small fraction of the sky. We uncovered several prominent UV-only objects lacking the counterparts in the catalogues of longer wavelengths, and discuss their possible nature. We also detected a single source showing an extreme UV to optical color and corresponding to UV flare on a cool sdM subdwarf star. Finally, we discuss the possible populations of objects that may be revealed in a future larger-scale analysis of this kind., Comment: 8 pages, 7 figures, 3 tables. Accepted to MNRAS

This work is centred around the recently proposed product key memory structure \cite{large_memory}, implemented for a number of computer vision applications. The memory structure can be regarded as a simple computation primitive suitable to be augmented to nearly all neural network architectures. The memory block allows implementing sparse access to memory with square root complexity scaling with respect to the memory capacity. The latter scaling is possible due to the incorporation of Cartesian product space decomposition of the key space for the nearest neighbour search. We have tested the memory layer on the classification, image reconstruction and relocalization problems and found that for some of those, the memory layers can provide significant speed/accuracy improvement with the high utilization of the key-value elements, while others require more careful fine-tuning and suffer from dying keys. To tackle the later problem we have introduced a simple technique of memory re-initialization which helps us to eliminate unused key-value pairs from the memory and engage them in training again. We have conducted various experiments and got improvements in speed and accuracy for classification and PoseNet relocalization models. We showed that the re-initialization has a huge impact on a toy example of randomly labeled data and observed some gains in performance on the image classification task. We have also demonstrated the generalization property perseverance of the large memory layers on the relocalization problem, while observing the spatial correlations between the images and the selected memory cells., Comment: Master's dissertation paper

Анализ проведенных тестирований физической подготовленности военнослужащих показывает, не знание некоторых военнослужащих основных принципов и методов физического развития, а также не умения составлять план самостоятельных занятий. Данная статья содержит формы, задачи, основные принципы и методы физической подготовки.

Анализ проведенных тестирований физической подготовленности военнослужащих показывает, не знание некоторых военнослужащих основных принципов и методов физического развития, а также не умения составлять план самостоятельных занятий. Данная статья содержит формы, задачи, основные принципы и методы физической подготовки.

In this work we’ve designed a series of new chiral Lewis Bases and show their excellent catalytic ability in the reaction of asymmetric propargylation of aromatic and α-unsaturated aldehydes.

Анализ литературных источников показал недостаточную освещенность вопроса подготовки к сдаче нормативов в упражнении челночный бег 10*10 м. Можно встретить общее описание упражнения, но без конкретных рекомендаций, либо общие рекомендации к подготовке к зачету на 60 – 100 м. Хоть методика подготовки к зачету на 60, 100 м и схожа с методикой подготовки к челночному бегу 10*10 м, но все же имеет ряд кардинальных отличий. Данная статья содержит средства, методы, а также практические рекомендации для подготовки к выполнению. норматива челночный бег 10*10 м., Analysis of literature sources showed insufficient coverage of the issue of preparation for passing the standards in the exercise Shuttle run 10*10 m. You can find a General description of the exercise, but without specific recommendations, or General recommendations for preparing for the 60 – 100m test. Although the method of preparation for the 60, 100 m competition is similar to the method of preparation for the 10*10 m shuttle run, it still has a number of fundamental differences. This article contains tools, methods, and practical recommendations for preparing for implementation. standard shuttle run 10*10 m.

Special conditions associated with laboratory autoimmune testing are not well compatible with recent developments in regulatory frameworks such as EN/ISO 15189 accreditation or in vitro diagnostic medical device regulation (IVD-R). In addition, international recommendations, guidelines and disease criteria are poorly defined with respect to requirements on autoantibody testing. Laboratory specialists from Austria, Belgium, Croatia, Estonia, Finland, France, Germany, Greece, Hungary, Italy, Norway, Poland, Portugal, South Africa, Spain, Sweden, Switzerland, and The Netherlands collected information, reported national experience, and identified quality issues in relation to autoantibody testing that require consensus on interpretation of the regulatory frameworks and guidelines. This process has been organized by the European Autoimmunity Standardisation Initiative (EASI). By identifying the critical items and looking for a consensus, our objective was to define a framework for, in particular, EN/ISO accreditation purposes. Here, we present a review of current publications and guidelines in this field to unify national guidelines and deliver in this way a European handout on quality control and accreditation for laboratories involved in autoantibody testing. We focus on quality items that can be checked during accreditation visits. Despite various local varieties, we encountered an overwhelming dedication to quality assurance in all contributing countries.

Special conditions associated with laboratory autoimmune testing are not well compatible with recent developments in regulatory frameworks such as EN/ISO 15189 accreditation or in vitro diagnostic medical device regulation (IVD-R). In addition, international recommendations, guidelines and disease criteria are poorly defined with respect to requirements on autoantibody testing. Laboratory specialists from Austria, Belgium, Croatia, Estonia, Finland, France, Germany, Greece, Hungary, Italy, Norway, Poland, Portugal, South Africa, Spain, Sweden, Switzerland, and The Netherlands collected information, reported national experience, and identified quality issues in relation to autoantibody testing that require consensus on interpretation of the regulatory frameworks and guidelines. This process has been organized by the European Autoimmunity Standardisation Initiative (EASI). By identifying the critical items and looking for a consensus, our objective was to define a framework for, in particular, EN/ISO accreditation purposes. Here, we present a review of current publications and guidelines in this field to unify national guidelines and deliver in this way a European handout on quality control and accreditation for laboratories involved in autoantibody testing. We focus on quality items that can be checked during accreditation visits. Despite various local varieties, we encountered an overwhelming dedication to quality assurance in all contributing countries.

Special conditions associated with laboratory autoimmune testing are not well compatible with recent developments in regulatory frameworks such as EN/ISO 15189 accreditation or in vitro diagnostic medical device regulation (IVD-R). In addition, international recommendations, guidelines and disease criteria are poorly defined with respect to requirements on autoantibody testing. Laboratory specialists from Austria, Belgium, Croatia, Estonia, Finland, France, Germany, Greece, Hungary, Italy, Norway, Poland, Portugal, South Africa, Spain, Sweden, Switzerland, and The Netherlands collected information, reported national experience, and identified quality issues in relation to autoantibody testing that require consensus on interpretation of the regulatory frameworks and guidelines. This process has been organized by the European Autoimmunity Standardisation Initiative (EASI). By identifying the critical items and looking for a consensus, our objective was to define a framework for, in particular, EN/ISO accreditation purposes. Here, we present a review of current publications and guidelines in this field to unify national guidelines and deliver in this way a European handout on quality control and accreditation for laboratories involved in autoantibody testing. We focus on quality items that can be checked during accreditation visits. Despite various local varieties, we encountered an overwhelming dedication to quality assurance in all contributing countries.

Special conditions associated with laboratory autoimmune testing are not well compatible with recent developments in regulatory frameworks such as EN/ISO 15189 accreditation or in vitro diagnostic medical device regulation (IVD-R). In addition, international recommendations, guidelines and disease criteria are poorly defined with respect to requirements on autoantibody testing. Laboratory specialists from Austria, Belgium, Croatia, Estonia, Finland, France, Germany, Greece, Hungary, Italy, Norway, Poland, Portugal, South Africa, Spain, Sweden, Switzerland, and The Netherlands collected information, reported national experience, and identified quality issues in relation to autoantibody testing that require consensus on interpretation of the regulatory frameworks and guidelines. This process has been organized by the European Autoimmunity Standardisation Initiative (EASI). By identifying the critical items and looking for a consensus, our objective was to define a framework for, in particular, EN/ISO accreditation purposes. Here, we present a review of current publications and guidelines in this field to unify national guidelines and deliver in this way a European handout on quality control and accreditation for laboratories involved in autoantibody testing. We focus on quality items that can be checked during accreditation visits. Despite various local varieties, we encountered an overwhelming dedication to quality assurance in all contributing countries.