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1. Photoreforming of glycerol to produce hydrogen from natural water in a compound parabolic collector solar photoreactor

Author

Ministerio de Ciencia, Innovación y Universidades (España), Polish National Agency for Academic Exchange, Agencia Estatal de Investigación (España), Colón, Gerardo[0000-0002-4086-0270], Villachica-Llamosas, J. G., Sowik, Jakub, Ruiz-Aguirre, A., COLON IBAÑEZ, GERARDO, Peral, J., Malato, S., Ministerio de Ciencia, Innovación y Universidades (España), Polish National Agency for Academic Exchange, Agencia Estatal de Investigación (España), Colón, Gerardo[0000-0002-4086-0270], Villachica-Llamosas, J. G., Sowik, Jakub, Ruiz-Aguirre, A., COLON IBAÑEZ, GERARDO, Peral, J., and Malato, S.

Abstract

To improve TiO2 for H2 generation, one strategy for the separation of photogenerated charges is the formation of heterostructures with other materials. In particular, NiO is a photocatalyst known for its good stability and low cost. However, no studies at pilot scale using solar energy have been described. Consequently, an evaluation of a physical NiO:TiO2 mixture at pilot scale (25 L) with natural irradiation (2.10 m2 of sun-exposed surface) and with simultaneous glycerol photoreforming was explored. NiO:TiO2 50 mg·L−1 resulted in the highest hydrogen production, showing an STH = 1.44%, considering only the UV fraction of the solar irradiation. H2 and CO2 production were analysed by on-line GC; Glycerol, dissolved organic carbon, carboxylic acids and nickel leaching were also evaluated. The NiO:TiO2 mixtures rendered a systematically lower H2 production in natural water than in high-purity water. The increase of ionic strength increased the mean size of particle clusters, promoting rapid sedimentation. All this indicates the importance of testing under real field conditions for attaining reliable solar to hydrogen (STH) efficiency.

Published
2023

2. Diseño de un controlador multivariable para la regeneración de aguas con nanofiltración

Author

Roca, Lidia, Serrano Rodríguez, Juan Miguel, Rodríguez, Francisco, Laconis, Franceso, Oller, I., Malato, S., Roca, Lidia, Serrano Rodríguez, Juan Miguel, Rodríguez, Francisco, Laconis, Franceso, Oller, I., and Malato, S.

Abstract

[Resumen] Una de las principales preocupaciones sobre la regeneración de aguas municipales residuales es la eliminación de microcontaminantes, como plaguicidas o compuestos farmacéuticos, junto con microorganismos perjudiciales. Una metodología para llevar a cabo dicha eliminación es mediante la combinación de sistemas de nanofiltración apropiados con sistemas avanzados de oxidación. Este trabajo se centra en mejorar el proceso de nanofiltración desde el punto de vista del control automático, con el fin de contribuir a la posible industrialización del proceso para la aplicación de separación y pre-concentración de microcontaminantes de efluentes procedentes de plantas de tratamiento de aguas residuales municipales. Al tratarse de un sistema multivariable con interacción, se ha aplicado la técnica de desacoplamiento invertido en simulación, mejorando la calidad del control en un 18% frente al caso sin desacoplo., [Abstract] The removal of microcontaminants, such as pharmaceuticals compounds or pesticides, which is one of the main concerns in municipal wastewater regeneration jointly with harmful microorganisms, can be performed through the combination of appropriate nanofiltration (NF) systems with advanced oxidation post-treatments. This work analyzes the optimization of the NF process operation to contribute to the industrialization of this application for the separation and pre-concentration of microcontaminants from municipal wastewater treatment plant effluents. It consists in a multivariable system with coupling between its variables, applying the inverted decoupling method, the control perfomance has been improved 18% with respect to the case with no decoupler, in simulation.

Published
2022

3. PH plus STEM CELLS (SCS) IN CHRONIC MYELOID LEUKEMIA (CML): TO ERADICATE OR NOT TO ERADICATE, THIS IS THE QUESTION

Author

Pungolino, E, D'Adda, M, Trojani, A, Perego, A, Elena, C, Iurlo, A, Malato, S, Turrini, M, De Canal, G, Borin, L, Bossi, L, Caramella, M, Artale, S, Spina, F, Latargia, M, Anghilieri, M, Spedini, P, Carraro, M, Di Camillo, B, Gramegna, D, Pioltelli, M, Rossi, G, Morra, E, Cairoli, R, Pungolino E, D'adda M, Trojani A, Perego A, Elena C, Iurlo A, Malato S, Turrini M, De Canal G, Borin L, Bossi LE, Caramella M, Artale S, Spina F, Latargia ML, Anghilieri M, Spedini P, Carraro MC, Di Camillo B, Gramegna D, Pioltelli ML, Rossi G, Morra E, Cairoli R, Pungolino, E, D'Adda, M, Trojani, A, Perego, A, Elena, C, Iurlo, A, Malato, S, Turrini, M, De Canal, G, Borin, L, Bossi, L, Caramella, M, Artale, S, Spina, F, Latargia, M, Anghilieri, M, Spedini, P, Carraro, M, Di Camillo, B, Gramegna, D, Pioltelli, M, Rossi, G, Morra, E, Cairoli, R, Pungolino E, D'adda M, Trojani A, Perego A, Elena C, Iurlo A, Malato S, Turrini M, De Canal G, Borin L, Bossi LE, Caramella M, Artale S, Spina F, Latargia ML, Anghilieri M, Spedini P, Carraro MC, Di Camillo B, Gramegna D, Pioltelli ML, Rossi G, Morra E, and Cairoli R

Published
2019

4. IDENTIFICAZIONE DI MIRNA E GENI TARGET NELL’ANALISI TRASCRITTOMICA DELLE CELLULE CD34+/LIN- DI PAZIENTI CON LEUCEMIA MIELOIDE CRONICA IN FASE CRONICA DOPO 12 MESI DI TERAPIA CON NILOTINIB

Author

Trojani, A, Pungolino, E, Dal Molin, A, Bossi, L, Rossi, G, D'Adda, M, Perego, A, Elena, C, Turrini, M, Borin, L, Bucelli, C, Malato, S, Carraro, M, Spina, F, Latargia, M, Artale, S, Spedini, P, Anghilieri, M, Di Camillo, B, Baruzzo, G, De Canal, G, Iurlo, A, Morra, E, Cairoli, R, Trojani A, Pungolino E, Dal Molin A, Bossi LE, Rossi G, D'Adda M, Perego A, Elena C, Turrini M, Borin L, Bucelli C, Malato S, Carraro MC, Spina F, Latargia ML, Artale S, Spedini P, Anghilieri M, Di Camillo B, Baruzzo G, De Canal G, Iurlo A, Morra E, Cairoli R, Trojani, A, Pungolino, E, Dal Molin, A, Bossi, L, Rossi, G, D'Adda, M, Perego, A, Elena, C, Turrini, M, Borin, L, Bucelli, C, Malato, S, Carraro, M, Spina, F, Latargia, M, Artale, S, Spedini, P, Anghilieri, M, Di Camillo, B, Baruzzo, G, De Canal, G, Iurlo, A, Morra, E, Cairoli, R, Trojani A, Pungolino E, Dal Molin A, Bossi LE, Rossi G, D'Adda M, Perego A, Elena C, Turrini M, Borin L, Bucelli C, Malato S, Carraro MC, Spina F, Latargia ML, Artale S, Spedini P, Anghilieri M, Di Camillo B, Baruzzo G, De Canal G, Iurlo A, Morra E, and Cairoli R

Published
2019

5. Progressive Down Regulation of JAK-STAT, Cell Cycle, and ABC Transporter Genes in CD34+/Lin- Cells of Chronic-Phase Chronic Myeloid Leukemia (CP-CML) Patients at Diagnosis Vs. 12 Months of Nilotinib Treatment Vs. Healthy Subjects

Author

Trojani, A, Pungolino, E, Rossi, G, D'Adda, M, Bossi, L, Baruzzo, G, Di Camillo, B, Perego, A, Turrini, M, Elena, C, Borin, L, Iurlo, A, Malato, S, Spina, F, Latargia, M, Spedini, P, Artale, S, Anghilieri, M, Carraro, M, Bucelli, C, De Canal, G, Morra, E, Cairoli, R, Trojani A., Pungolino E., Rossi G., D'Adda M., Bossi L.E., Baruzzo G., Di Camillo B., Perego A., Turrini M., Elena C., Borin L.M., Iurlo A., Malato S., Spina F., Latargia M.L., Spedini P., Artale S., Anghilieri M., Carraro M.C., Bucelli C., De Canal G., Morra E., Cairoli R, Trojani, A, Pungolino, E, Rossi, G, D'Adda, M, Bossi, L, Baruzzo, G, Di Camillo, B, Perego, A, Turrini, M, Elena, C, Borin, L, Iurlo, A, Malato, S, Spina, F, Latargia, M, Spedini, P, Artale, S, Anghilieri, M, Carraro, M, Bucelli, C, De Canal, G, Morra, E, Cairoli, R, Trojani A., Pungolino E., Rossi G., D'Adda M., Bossi L.E., Baruzzo G., Di Camillo B., Perego A., Turrini M., Elena C., Borin L.M., Iurlo A., Malato S., Spina F., Latargia M.L., Spedini P., Artale S., Anghilieri M., Carraro M.C., Bucelli C., De Canal G., Morra E., and Cairoli R

Published
2019

6. Different approaches for the solar photocatalytic removal of micro-contaminants from aqueous environment: Titania vs. hybrid magnetic iron oxides

Author

Polliotto, V, Pomilla, F, Maurino, V, Marcì, G, Bianco Prevot, A, Nistico', R, Magnacca, G, Paganini, M, Ponce Robles, L, Perez, L, Malato, S, Polliotto, V., Pomilla, F. R., Maurino, V., Marcì, G., Bianco Prevot, A., Nistico', R., Magnacca, G., Paganini, M. C., Ponce Robles, L., Perez, L., Malato, S., Polliotto, V, Pomilla, F, Maurino, V, Marcì, G, Bianco Prevot, A, Nistico', R, Magnacca, G, Paganini, M, Ponce Robles, L, Perez, L, Malato, S, Polliotto, V., Pomilla, F. R., Maurino, V., Marcì, G., Bianco Prevot, A., Nistico', R., Magnacca, G., Paganini, M. C., Ponce Robles, L., Perez, L., and Malato, S.

Abstract

This work reports on the light-induced heterogeneous photodegradation of four micro-contaminants (MCs): Carbamazepine (C), Flumequine (F), Ibuprofen (I), and Sulfamethoxazole (S), using two different heterogeneous advanced oxidation processes. The first one is the semiconductor photocatalysis, run in the presence of the suspension of a home prepared TiO 2 (TiO 2 HP); the second one is an heterogeneous photo-Fenton process run in the presence of a hybrid magnetic nanomaterial (MB3) with an iron oxides core and an organic shell made of bio-based substances (BBS) isolated from urban biowaste. The two materials work upon two different mechanisms and were already tested (and the action mechanism hypothesized) at the lab scale under model conditions: TiO 2 acts as photocatalyst through the photo-generation of hole/electron pairs able to give rise to oxidation and reduction reactions, whereas hybrid magnetic nanomaterial acts in the presence of H 2 O 2 by a photo-Fenton like mechanism. The results evidenced the better performances of TiO 2 HP (also better than the well-known reference TiO 2 P25). Preliminary photodegradation experiments carried out in a pilot plant under natural solar radiation confirmed the good results obtained with TiO 2 HP. Moreover, in the adopted experimental conditions, the Fe(II) leached from MB3 can be considered as responsible of the MCs degradation through a homogeneous photo-Fenton reaction, where MB3 act as iron reservoir.

Published
2019

7. Deferasirox in the management of iron-overload in patients with myelofibrosis: a multicentre study from the Rete Ematologica Lombarda (IRON-M study)

Author

Elli, E, Iurlo, A, Aroldi, A, Caramella, M, Malato, S, Casartelli, E, Maffioli, M, Gardellini, A, Carraro, M, D'Adda, M, Polverelli, N, Rossi, M, Orofino, N, Carrer, A, Gambacorti-Passerini, C, Antolini, L, Passamonti, F, Elli E. M., Iurlo A., Aroldi A., Caramella M., Malato S., Casartelli E., Maffioli M., Gardellini A., Carraro M. C., D'Adda M., Polverelli N., Rossi M., Orofino N., Carrer A., Gambacorti-Passerini C., Antolini L., Passamonti F., Elli, E, Iurlo, A, Aroldi, A, Caramella, M, Malato, S, Casartelli, E, Maffioli, M, Gardellini, A, Carraro, M, D'Adda, M, Polverelli, N, Rossi, M, Orofino, N, Carrer, A, Gambacorti-Passerini, C, Antolini, L, Passamonti, F, Elli E. M., Iurlo A., Aroldi A., Caramella M., Malato S., Casartelli E., Maffioli M., Gardellini A., Carraro M. C., D'Adda M., Polverelli N., Rossi M., Orofino N., Carrer A., Gambacorti-Passerini C., Antolini L., and Passamonti F.

Published
2019

8. Wide-transcriptome analysis and cellularity of bone marrow CD34+/lin- cells of patients with chronic-phase chronic myeloid leukemia at diagnosis vs. 12 months of first-line nilotinib treatment

Author

Trojani, A, Pungolino, E, Rossi, G, D'Adda, M, Lodola, M, Di Camillo, B, Perego, A, Turrini, M, Orlandi, E, Borin, L, Iurlo, A, Malato, S, Spina, F, Latargia, M, Lanza, F, Artale, S, Anghilieri, M, Carraro, M, De Canal, G, Morra, E, Cairoli, R, Trojani A, Pungolino E, Rossi G, D'Adda M, Lodola M, Di Camillo B, Perego A, Turrini M, Orlandi E, Borin L, Iurlo A, Malato S, Spina F, Latargia ML, Lanza F, Artale S, Anghilieri M, Carraro MC, De Canal G, Morra E, Cairoli R, Trojani, A, Pungolino, E, Rossi, G, D'Adda, M, Lodola, M, Di Camillo, B, Perego, A, Turrini, M, Orlandi, E, Borin, L, Iurlo, A, Malato, S, Spina, F, Latargia, M, Lanza, F, Artale, S, Anghilieri, M, Carraro, M, De Canal, G, Morra, E, Cairoli, R, Trojani A, Pungolino E, Rossi G, D'Adda M, Lodola M, Di Camillo B, Perego A, Turrini M, Orlandi E, Borin L, Iurlo A, Malato S, Spina F, Latargia ML, Lanza F, Artale S, Anghilieri M, Carraro MC, De Canal G, Morra E, and Cairoli R

Abstract

BACKGROUND: Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder with heterogeneous biological and clinical features. The biomolecular mechanisms of CML response to tyrosine-kinase inhibitors are not fully defined. OBJECTIVE: We undertook a gene expression profiling (GEP) study of selected bone marrow (BM) CD34+/lin-cells of chronic-phase CML patients at diagnosis and after 12 months of TKI nilotinib to investigate molecular signatures characterizing both conditions. METHODS:We selected and counted BM CD34+/lin- cells of 30 CML patients at diagnosis and during 3, 6 and 12 months of first-line nilotinib treatment. GEP was performed between CD34+/lin- cells of patients at diagnosis and the same patients after 12 months of nilotinib. RESULTS: The number of BM CD34+/lin- cells dramatically decreased after 3, 6 and 12 months of nilotinib. GEP detected 264 statistically significant differentially expressed genes at diagnosis vs. 12 months of nilotinib. Functional enrichment analysis revealed groups of genes belonging to 14 pathways differentially active during nilotinib treatment. CONCLUSIONS: In conclusion, lipid, glucose and sphingolipid metabolism, insulin resistance, complement and coagulation, platelet activation, cytoscheleton, cell adhesion, transport, B cell differentiation, RAS-signaling pathway, proliferation, growth factors, and apoptosis were significantly deregulated between CML patients at diagnosis and after 12 months of nilotinib.

Published
2018

9. Combining Imatinib-Following-Nilotinib Treatment in First Line Therapy for Chronic Phase Chronic Myeloid Leukemia. Update from the PhilosoPhi34 Study at 24 Months of Follow-up

Author

Pioltelli, M, Pungolino, E, D'Adda, M, Elena, C, Borin, L, Perego, A, Malato, S, Spina, F, Artale, S, Carraro, M, Orofino, N, Anghilieri, M, Farina, M, Latargia, M, Iurlo, A, Trojani, A, Turrini, M, Caramella, M, Spedini, P, Rossi, G, Morra, E, Cairoli, R, Pioltelli ML, Pungolino E, D'adda M, Elena C, Borin LM, Perego A, Malato S, Spina F, Artale S, Carraro M, Orofino N, Anghilieri M, Farina M, Latargia ML, Iurlo A, Trojani A, Turrini M, Caramella M, Spedini P, Rossi G, Morra E, Cairoli R, Pioltelli, M, Pungolino, E, D'Adda, M, Elena, C, Borin, L, Perego, A, Malato, S, Spina, F, Artale, S, Carraro, M, Orofino, N, Anghilieri, M, Farina, M, Latargia, M, Iurlo, A, Trojani, A, Turrini, M, Caramella, M, Spedini, P, Rossi, G, Morra, E, Cairoli, R, Pioltelli ML, Pungolino E, D'adda M, Elena C, Borin LM, Perego A, Malato S, Spina F, Artale S, Carraro M, Orofino N, Anghilieri M, Farina M, Latargia ML, Iurlo A, Trojani A, Turrini M, Caramella M, Spedini P, Rossi G, Morra E, and Cairoli R

Published
2018

10. Identification of genes differently expressed between bone marrow CD34+/LIN-cells of patients with chronic-phase chronic myeloid leukemia at diagnosis vs 12 months of first-line nilotinib treatment

Author

Trojani, A, Pungolino, E, Rossi, G, D'Adda, M, Lodola, M, Di Camillo, B, Perego, A, Turrini, M, Orlandi, E, Borin, L, Iurlo, A, Bucelli, C, Malato, S, Spina, F, Latargia, M, Lanza, F, Artale, S, Anghilieri, M, Carraro, M, De Canal, G, Morra, E, Cairoli, R, Trojani A., Pungolino E., Rossi G., D'Adda M., Lodola M., Di Camillo B., Perego A., Turrini M., Orlandi E., Borin L., Iurlo A., Bucelli C., Malato S., Spina F., Latargia M.L., Lanza F., Artale S., Anghilieri M., Carraro M.C., De Canal G., Morra E., Cairoli R, Trojani, A, Pungolino, E, Rossi, G, D'Adda, M, Lodola, M, Di Camillo, B, Perego, A, Turrini, M, Orlandi, E, Borin, L, Iurlo, A, Bucelli, C, Malato, S, Spina, F, Latargia, M, Lanza, F, Artale, S, Anghilieri, M, Carraro, M, De Canal, G, Morra, E, Cairoli, R, Trojani A., Pungolino E., Rossi G., D'Adda M., Lodola M., Di Camillo B., Perego A., Turrini M., Orlandi E., Borin L., Iurlo A., Bucelli C., Malato S., Spina F., Latargia M.L., Lanza F., Artale S., Anghilieri M., Carraro M.C., De Canal G., Morra E., and Cairoli R

Published
2018

11. Nilotinib Deregulates Cell Cycle Checkpoints, ABC Transporters Genes and JAK-STAT Signaling Pathway of CD34+/Lin- Cells in Chronic-Phase Chronic Myeloid Leukemia (CP-CML) Patients after 12 Months of Treatment

Author

Trojani, A, Pungolino, E, Rossi, G, D'Adda, M, Lodola, M, Dal Molin, A, Baruzzo, G, Perego, A, Turrini, M, Elena, C, Borin, L, Iurlo, A, Malato, S, Spina, F, Latargia, M, Spedini, P, Artale, S, Anghilieri, M, Cristina, C, Bucelli, C, De Canal, G, Morra, E, Cairoli, R, Trojani A, Pungolino E, Rossi G, D'adda M, Lodola M, Dal Molin A, Baruzzo G, Perego A, Turrini M, Elena C, Borin LM, Iurlo A, Malato S, Spina F, Latargia ML, Spedini P, Artale S, Anghilieri M, Cristina CM, Bucelli C, De Canal G, Morra E, Cairoli R, Trojani, A, Pungolino, E, Rossi, G, D'Adda, M, Lodola, M, Dal Molin, A, Baruzzo, G, Perego, A, Turrini, M, Elena, C, Borin, L, Iurlo, A, Malato, S, Spina, F, Latargia, M, Spedini, P, Artale, S, Anghilieri, M, Cristina, C, Bucelli, C, De Canal, G, Morra, E, Cairoli, R, Trojani A, Pungolino E, Rossi G, D'adda M, Lodola M, Dal Molin A, Baruzzo G, Perego A, Turrini M, Elena C, Borin LM, Iurlo A, Malato S, Spina F, Latargia ML, Spedini P, Artale S, Anghilieri M, Cristina CM, Bucelli C, De Canal G, Morra E, and Cairoli R

Published
2018

12. Jak-2 and Nfkbia Gene Expression Play a Strategic Role in Chronic Myeloid Leukemia (CML) Molecular Response during Early Nilotinib Treatment: The PhilosoPhi34 Data

Author

Pungolino, E, D'Adda, M, Trojani, A, Perego, D, Pioltelli, M, Rossi, G, Perego, A, Elena, C, Iurlo, A, Malato, S, Turrini, M, De Canal, G, Borin, L, Lodola, M, Caramella, M, Artale, S, Spina, F, Latargia, M, Anghilieri, M, Spedini, P, Carraro, M, Di Camillo, B, Gramegna, D, Morra, E, Cairoli, R, Pungolino E, D'adda M, Trojani A, Perego D, Pioltelli ML, Rossi G, Perego A, Elena C, Iurlo A, Malato S, Turrini M, De Canal G, Borin L, Lodola M, Caramella M, Artale S, Spina F, Latargia ML, Anghilieri M, Spedini P, Carraro M, Di Camillo B, Gramegna D, Morra E, Cairoli R, Pungolino, E, D'Adda, M, Trojani, A, Perego, D, Pioltelli, M, Rossi, G, Perego, A, Elena, C, Iurlo, A, Malato, S, Turrini, M, De Canal, G, Borin, L, Lodola, M, Caramella, M, Artale, S, Spina, F, Latargia, M, Anghilieri, M, Spedini, P, Carraro, M, Di Camillo, B, Gramegna, D, Morra, E, Cairoli, R, Pungolino E, D'adda M, Trojani A, Perego D, Pioltelli ML, Rossi G, Perego A, Elena C, Iurlo A, Malato S, Turrini M, De Canal G, Borin L, Lodola M, Caramella M, Artale S, Spina F, Latargia ML, Anghilieri M, Spedini P, Carraro M, Di Camillo B, Gramegna D, Morra E, and Cairoli R

Published
2018

13. DIFFERENT SETS OF GENES WERE ASSOCIATED TO THE MOLECULAR RESPONSE AFTER 3 AND 6 MONTHS OF FIRST-LINE NILOTINIB TREATMENT BY MICROARRAY OF CD34+/LIN- CELLS OF CHRONIC PHASE CML PATIENTS AT DIAGNOSIS

Author

Trojani, A, Pungolino, E, Lodola, M, Di Camillo, B, D'Adda, M, Perego, A, Turrini, M, Orlandi, E, Elena, C, Iurlo, A, Bucelli, C, Borin, L, Malato, S, Spina, F, Latargia, M, Lanza, F, Artale, S, Anghilieri, M, Carraro, M, Bertinato, E, Morra, E, Cairoli, R, Trojani A, Pungolino E, Lodola M, Di Camillo B, D'Adda M, Perego A, Turrini M, Orlandi E, Elena C, Iurlo A, Bucelli C, Borin L, Malato S, Spina F, Latargia ML, Lanza F, Artale S, Anghilieri M, Carraro MC, Bertinato E, Morra E, Cairoli R, Trojani, A, Pungolino, E, Lodola, M, Di Camillo, B, D'Adda, M, Perego, A, Turrini, M, Orlandi, E, Elena, C, Iurlo, A, Bucelli, C, Borin, L, Malato, S, Spina, F, Latargia, M, Lanza, F, Artale, S, Anghilieri, M, Carraro, M, Bertinato, E, Morra, E, Cairoli, R, Trojani A, Pungolino E, Lodola M, Di Camillo B, D'Adda M, Perego A, Turrini M, Orlandi E, Elena C, Iurlo A, Bucelli C, Borin L, Malato S, Spina F, Latargia ML, Lanza F, Artale S, Anghilieri M, Carraro MC, Bertinato E, Morra E, and Cairoli R

Published
2016

14. Genes and Pathways Dysregulated by Nilotinib Treatment in Bone Marrow CD34+/Lin- Cells of Patients with Chronic-Phase Chronic Myeloid Leukaemia

Author

Alessandra, T, Ester, P, Alessandra Dal, M, Milena, L, Gabriella De, C, Giuseppe, R, Mariella, D, Alessandra, P, Ester, O, Malato, S, Mauro, T, Lorenza, B, Alessandra, I, Maria Luisa, L, Maria Cristina, C, Francesco, S, Salvatore, A, Michela, A, Francesco, L, Enrica, M, Cairoli, R, Alessandra Trojani, Ester Pungolino, Alessandra Dal Molin, Milena Lodola, Gabriella De Canal, Giuseppe Rossi, Mariella D’Adda, Alessandra Perego, Ester Orlandi, Malato Simona, Mauro Turrini, Lorenza Borin, Alessandra Iurlo, Maria Luisa Latargia, Maria Cristina Carraro, Francesco Spina, Salvatore Artale, Michela Anghilieri, Francesco Lanza, Enrica Morra, Cairoli Roberto, Alessandra, T, Ester, P, Alessandra Dal, M, Milena, L, Gabriella De, C, Giuseppe, R, Mariella, D, Alessandra, P, Ester, O, Malato, S, Mauro, T, Lorenza, B, Alessandra, I, Maria Luisa, L, Maria Cristina, C, Francesco, S, Salvatore, A, Michela, A, Francesco, L, Enrica, M, Cairoli, R, Alessandra Trojani, Ester Pungolino, Alessandra Dal Molin, Milena Lodola, Gabriella De Canal, Giuseppe Rossi, Mariella D’Adda, Alessandra Perego, Ester Orlandi, Malato Simona, Mauro Turrini, Lorenza Borin, Alessandra Iurlo, Maria Luisa Latargia, Maria Cristina Carraro, Francesco Spina, Salvatore Artale, Michela Anghilieri, Francesco Lanza, Enrica Morra, and Cairoli Roberto

Published
2018

15. Magnetic hybrid nanomaterials for the photodegradation of microcontaminats in aqueous environment

Author

Polliotto, V, Pomilla, F, Maurino, V, Marcì, G, Bianco Prevot, A, Nisticò, R, Magnacca, G, Paganini, M, Ponce Robles, L, Malato, S, V. Polliotto, F. R. Pomilla, V. Maurino, G. Marcì, A. Bianco Prevot, R. Nisticò, G. Magnacca, M. C. Paganini, L. Ponce Robles, S. Malato, Polliotto, V, Pomilla, F, Maurino, V, Marcì, G, Bianco Prevot, A, Nisticò, R, Magnacca, G, Paganini, M, Ponce Robles, L, Malato, S, V. Polliotto, F. R. Pomilla, V. Maurino, G. Marcì, A. Bianco Prevot, R. Nisticò, G. Magnacca, M. C. Paganini, L. Ponce Robles, and S. Malato

Abstract

Magnetic hybrid nanomaterials for the photodegradation of microcontaminats in aqueous environment

Published
2018

16. Solar pilot plant scale hydrogen generation by irradiation of Cu/TiO2 composites in presence of sacrificial electron donors

Author

Agencia Estatal de Investigación (España), European Commission, Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Maldonado, M. I., López-Martín, Ángeles, Colón, Gerardo, Peral, J., Martínez-Costa, J.I., Malato, S., Agencia Estatal de Investigación (España), European Commission, Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Maldonado, M. I., López-Martín, Ángeles, Colón, Gerardo, Peral, J., Martínez-Costa, J.I., and Malato, S.

Abstract

A Cu/TiO2 photocatalyst has been synthesised by reducing a Cu precursor with NaBH4 onto the surface of a sulphate pretreated TiO2 obtained by a sol-gel procedure. The catalyst, that shows a clearly defined anatase phase with high crystallinity and relatively high surface area, and contains Cu2O and CuO deposits on its surface, has been used to produce hydrogen in a solar driven pilot plant scale photocatalytic reactor. Different electron donor aqueous solutions (methanol, glycerol, and a real municipal wastewater treatment plant influent) have been tested showing similar or even higher energy efficiency than those obtained using more expensive noble metal based photocatalytic systems. The glycerol solutions have provided the best reactive environments for hydrogen generation.

Published
2018

17. Modelado y control de una planta piloto de nanofiltración aplicada a la reutilización de aguas residuales en agricultura

Author

Sánchez Pelegrina, A.I., Rodríguez, F., Oller, I., Berenguel, M., Malato, S., Sánchez Pelegrina, A.I., Rodríguez, F., Oller, I., Berenguel, M., and Malato, S.

Abstract

[Resumen] Actualmente es necesario el uso de instalaciones de tratamiento de aguas residuales debido a la escasez de recursos hídricos de calidad. Las plantas de nanofiltración presentan cada vez más interés, ya que requieren menos energía que otros sistemas. En la Plataforma Solar de Almería se utiliza una planta de nanofiltración gestionada de forma manual basándose en la experiencia de los operarios. En este trabajo se muestra el proceso de análisis, modelado y control de esta planta, que ha ayudado a mejorar el conocimiento de la misma, a determinar su punto de operación e identificar las variables que más influyen en el comportamiento del sistema. Además, con la arquitectura de control propuesta, basada en un controlador multivariable con desacoplo, se puede llegar a alcanzar unas condiciones idóneas de funcionamiento en cuanto a producción, seguridad y mantenimiento de las membranas, como se puede observar en los resultados que se presentan., [Abstract] Nowadays, the use of wastewater treatment facilities is necessary due to the scarcity of quality water resources. Nanofiltration plants are becoming more and more interesting, since they require less energy than other systems. A manually operated nanofiltration plant is used at Plataforma Solar de Almería, based on the operators’ experience. This work is devoted to the analysis, modeling and control of this kind of plant, which has helped to both improve knowledge and to determine the optimal operating point and identify the variables that most influence the behavior of the system. Furthermore, an automatic control architecture is proposed, based on a multivariable controller with decoupling. It is possible to achieve ideal operating conditions in terms of production, safety and membranes maintenance, as can be seen in the results presented.

Published
2018

18. Gene Expression Profiling of CD34+/Lin- Cells of Patients with Chronic Myeloid Leukemia at Diagnosis and after 12 Months of Nilotinib

Author

Trojani, A, Lodola, M, Di Camillo, B, Rossi, G, Capucci, A, Perego, A, Pogliani, E, Orlandi, E, Iurlo, A, Malato, S, Corradini, P, Cairoli, R, Bregni, M, Artale, S, Morra, E, Pungolino, E, Trojani A, Lodola M, Di Camillo B, Rossi G, Capucci A, Perego A, Pogliani EM, Orlandi E, Iurlo A, Malato S, Corradini P, Cairoli R, Bregni M, Artale S, Morra E, Pungolino E, Trojani, A, Lodola, M, Di Camillo, B, Rossi, G, Capucci, A, Perego, A, Pogliani, E, Orlandi, E, Iurlo, A, Malato, S, Corradini, P, Cairoli, R, Bregni, M, Artale, S, Morra, E, Pungolino, E, Trojani A, Lodola M, Di Camillo B, Rossi G, Capucci A, Perego A, Pogliani EM, Orlandi E, Iurlo A, Malato S, Corradini P, Cairoli R, Bregni M, Artale S, Morra E, and Pungolino E

Published
2014

19. GENE EXPRESSION PROFILING OF CD34+/LIN- CELLS OF PATIENTS WITH CHRONIC MYELOID LEUKEMIA AT DIAGNOSIS IDENTIFIES NEW GENES RELATED TO THE NUMBER OF CD34+/LIN- CELLS DURING NILOTINIB TREATMENT

Author

Trojani, A, Lodola, M, Di Camillo, B, Capucci, A, Cavalli, L, Perego, A, Pogliani, E, Orlandi, E, Iurlo, A, Malato, S, Corradini, P, Cairoli, R, Bregni, M, Pauli, S, Morra, E, Pungolino, E, Trojani A, Lodola M, Di Camillo B, Capucci A, Cavalli L, Perego A, Pogliani E, Orlandi E, Iurlo A, Malato S, Corradini P, Cairoli R, Bregni M, Pauli S, Morra E, Pungolino E, Trojani, A, Lodola, M, Di Camillo, B, Capucci, A, Cavalli, L, Perego, A, Pogliani, E, Orlandi, E, Iurlo, A, Malato, S, Corradini, P, Cairoli, R, Bregni, M, Pauli, S, Morra, E, Pungolino, E, Trojani A, Lodola M, Di Camillo B, Capucci A, Cavalli L, Perego A, Pogliani E, Orlandi E, Iurlo A, Malato S, Corradini P, Cairoli R, Bregni M, Pauli S, Morra E, and Pungolino E

Published
2014

20. Microarray of Bone Marrow CD34+/Lin- Cells from Patients with Chronic Myeloid Leukemia (CML)

Author

Trojani, A, Lodola, M, Di Camillo, B, Rossi, G, Capucci, A, Perego, A, Pogliani, E, Orlandi, E, Iurlo, A, Malato, S, Corradini, P, Cairoli, R, Bregni, M, Pauli, S, Morra, E, Pungolino, E, Trojani A, Lodola M, Di Camillo B, Rossi G, Capucci A, Perego A, Pogliani EM, Orlandi E, Iurlo A, Malato S, Corradini P, Cairoli R, Bregni M, Pauli S, Morra E, Pungolino E, Trojani, A, Lodola, M, Di Camillo, B, Rossi, G, Capucci, A, Perego, A, Pogliani, E, Orlandi, E, Iurlo, A, Malato, S, Corradini, P, Cairoli, R, Bregni, M, Pauli, S, Morra, E, Pungolino, E, Trojani A, Lodola M, Di Camillo B, Rossi G, Capucci A, Perego A, Pogliani EM, Orlandi E, Iurlo A, Malato S, Corradini P, Cairoli R, Bregni M, Pauli S, Morra E, and Pungolino E

Published
2014

21. Gene Expression Profiling and Cellularity of Bone Marrow CD34+/Lin- Cells of Patients with Chronic-Phase Chronic Myeloid Leukemia at Diagnosis Vs. 12 Months of First-Line Nilotinib Treatment

Author

Trojani, A, Pungolino, E, Rossi, G, D'Adda, M, Lodola, M, Di Camillo, B, Perego, A, Turrini, M, Orlandi, E, Borin, L, Iurlo, A, Malato, S, Spina, F, Latargia, M, Lanza, F, Artale, S, Anghilieri, M, Carraro, M, Bucelli, C, De Canal, G, Morra, E, Cairoli, R, Orlandi, EM, Borin, LM, Latargia, ML, Carraro, MC, Cairoli R, Trojani, A, Pungolino, E, Rossi, G, D'Adda, M, Lodola, M, Di Camillo, B, Perego, A, Turrini, M, Orlandi, E, Borin, L, Iurlo, A, Malato, S, Spina, F, Latargia, M, Lanza, F, Artale, S, Anghilieri, M, Carraro, M, Bucelli, C, De Canal, G, Morra, E, Cairoli, R, Orlandi, EM, Borin, LM, Latargia, ML, Carraro, MC, and Cairoli R

Published
2017

22. Preliminary Experience of Imatinib after Nilotinib in the First Line Treatment of Chronic Myeloid Leukemia

Author

Pungolino, E, D'Adda, M, Perego, A, Orlandi, E, Turrini, M, Borin, L, Iurlo, A, Artale, S, Latargia, M, Anghilieri, M, Malato, S, Trojani, A, Spina, F, Carraro, M, Pioltelli, M, Elena, C, Bucelli, C, Spedini, P, Rossi, G, Morra, E, Cairoli, R, D'adda M, Perego A, Orlandi, EM, Borin, LM, Latargia, ML, Carraro, MC, Pioltelli, ML, Pungolino, E, D'Adda, M, Perego, A, Orlandi, E, Turrini, M, Borin, L, Iurlo, A, Artale, S, Latargia, M, Anghilieri, M, Malato, S, Trojani, A, Spina, F, Carraro, M, Pioltelli, M, Elena, C, Bucelli, C, Spedini, P, Rossi, G, Morra, E, Cairoli, R, D'adda M, Perego A, Orlandi, EM, Borin, LM, Latargia, ML, Carraro, MC, and Pioltelli, ML

Published
2017

23. REL-PROTOCOL PHILOSOPHI34 CONFIRMS THAT NILOTINIB RAPIDLY INDUCES CD34+/LIN-PH+ CELLS DISAPPEARANCE IN PATIENTS WITH CHRONIC MYELOID LEUKAEMIA (CML) IN CHRONIC PHASE (CP)

Author

Pungolino, E, De Canal, G, D'Adda, M, Perego, A, Orlandi, E, Turrini, M, Trojani, A, Malato, S, Lodola, M, Borin, L, Iurlo, A, Artale, S, Spina, F, Pioltelli, M, Latargia, M, Brusorio, S, Elena, C, Lanza, F, Anghilieri, M, Carraro, M, Rossi, G, Morra, E, Cairoli, R, Orlandi, EM, Pioltelli, ML, Latargia, ML, Carraro, MC, Pungolino, E, De Canal, G, D'Adda, M, Perego, A, Orlandi, E, Turrini, M, Trojani, A, Malato, S, Lodola, M, Borin, L, Iurlo, A, Artale, S, Spina, F, Pioltelli, M, Latargia, M, Brusorio, S, Elena, C, Lanza, F, Anghilieri, M, Carraro, M, Rossi, G, Morra, E, Cairoli, R, Orlandi, EM, Pioltelli, ML, Latargia, ML, and Carraro, MC

Published
2016

24. GEP Analyses of Bone Marrow CD34+/Lin-Cells of Chronic Phase CML Patients at Diagnosis Identified Different Sets of Genes Associated to the Molecular Response after 3 and 6 Months of First-Line Nilotinib Treatment

Author

Trojani, A, Pungolino, E, Lodola, M, Di Camillo, B, D'Adda, M, Perego, A, Turrini, M, Elena, C, Iurlo, A, Buccelli, C, Malato, S, Spina, F, Latargia, M, Lanza, F, Pauli, S, Anghilieri, M, Carraro, M, Morra, E, Cairoli, R, Latargia, ML, Carraro, MC, Trojani, A, Pungolino, E, Lodola, M, Di Camillo, B, D'Adda, M, Perego, A, Turrini, M, Elena, C, Iurlo, A, Buccelli, C, Malato, S, Spina, F, Latargia, M, Lanza, F, Pauli, S, Anghilieri, M, Carraro, M, Morra, E, Cairoli, R, Latargia, ML, and Carraro, MC

Published
2015

25. REL-Protocol PhilosoPhi34: An Open Label, Single Arm, Phase II Study of Nilotinib 300 Mg BID in Newly Diagnosed Chronic Phase Chronic Myeloid Leukaemia Patients, to Study the Disappearance of CD34+/Lin-Ph+ Cells from Bone Marrow during Treatment. Preliminary Data

Author

Pungolino, E, Rossi, G, Angela Mura, M, Perego, A, Maria Orlandi, E, Turrini, M, Borin, L, Adele Capucci, M, Iurlo, A, Trojani, A, D'Adda, M, Spina, F, De Canal, G, Luisa Pioltelli, M, Luisa Latargia, M, Pauli, S, Elena, C, Brusorio, S, Lanza, F, Malato, S, Anghilieri, M, C Carraro, M, Morra, E, Cairoli, R, Ester Pungolino, Giuseppe Rossi, Maria Angela Mura, Alessandra Perego, Ester Maria Orlandi, Mauro Turrini, Lorenza Borin, Maria Adele Capucci, Alessandra Iurlo, Alessandra Trojani, Mariella D'Adda, Francesco Spina, Gabriella De Canal, Maria Luisa Pioltelli, Maria Luisa Latargia, Sergio Pauli, Chiara Elena, Stefania Brusorio, Francesco Lanza, Simona Malato, Michela Anghilieri, Maria C Carraro, Enrica Morra, Roberto Cairoli, Pungolino, E, Rossi, G, Angela Mura, M, Perego, A, Maria Orlandi, E, Turrini, M, Borin, L, Adele Capucci, M, Iurlo, A, Trojani, A, D'Adda, M, Spina, F, De Canal, G, Luisa Pioltelli, M, Luisa Latargia, M, Pauli, S, Elena, C, Brusorio, S, Lanza, F, Malato, S, Anghilieri, M, C Carraro, M, Morra, E, Cairoli, R, Ester Pungolino, Giuseppe Rossi, Maria Angela Mura, Alessandra Perego, Ester Maria Orlandi, Mauro Turrini, Lorenza Borin, Maria Adele Capucci, Alessandra Iurlo, Alessandra Trojani, Mariella D'Adda, Francesco Spina, Gabriella De Canal, Maria Luisa Pioltelli, Maria Luisa Latargia, Sergio Pauli, Chiara Elena, Stefania Brusorio, Francesco Lanza, Simona Malato, Michela Anghilieri, Maria C Carraro, Enrica Morra, and Roberto Cairoli

Published
2015

26. Light-induced catalytic transformation of ofloxacin by solar Fenton in various water matrices at a pilot plant: Mineralization and characterization of major intermediate products

Author

Michael, I., Hapeshi, E., Aceña, J., Pérez, Sandra, Petrovic, M., Zapata, A., Barceló, Damià, Malato, S., Fatta-Kassinos, Despo, Michael, I., Hapeshi, E., Aceña, J., Pérez, Sandra, Petrovic, M., Zapata, A., Barceló, Damià, Malato, S., and Fatta-Kassinos, Despo

Abstract

This work investigated the application of a solar driven advanced oxidation process (solar Fenton), for the degradation of the antibiotic ofloxacin (OFX) in various environmental matrices at a pilot-scale. All experiments were carried out in a compound parabolic collector pilot plant in the presence of doses of H2O2 (2.5mgL-1) and at an initial Fe2+ concentration of 2mgL-1. The water matrices used for the solar Fenton experiments were: demineralized water (DW), simulated natural freshwater (SW), simulated effluent from municipal wastewater treatment plant (SWW) and pre-treated real effluent from municipal wastewater treatment plant (RE) to which OFX had been spiked at 10mgL-1. Dissolved organic carbon removal was found to be dependent on the chemical composition of the water matrix. OFX mineralization was higher in DW (78.1%) than in SW (58.3%) at 12mgL-1 of H2O2 consumption, implying the complexation of iron or the scavenging of hydroxyl radicals by the inorganic ions present in SW. On the other hand, the presence of dissolved organic matter (DOM) in SWW and RE, led to lower mineralization per dose of H2O2 compared to DW and SW. The major transformation products (TPs) formed during the solar Fenton treatment of OFX, were elucidated using liquid chromatography-time of flight-mass spectrometry (LC-ToF-MS). The transformation of OFX proceeded through a defluorination reaction, accompanied by some degree of piperazine and quinolone substituent transformation while a hydroxylation mechanism occurred by attack of the hydroxyl radicals generated during the process leading to the formation of TPs in all the water matrices, seven of which were tentatively identified. The results obtained from the toxicity bioassays indicated that the toxicity originates from the DOM present in RE and its oxidation products formed during the photocatalytic treatment and not from the TPs resulted from the oxidation of OFX. © 2013 The Authors.

Published
2013

27. Fe-zeolites as heterogeneous catalysts in solar Fenton-like reactions at neutral pH

Author

Gonzalez-Olmos, Rafael, Martin, M.J., Georgi, Anett, Kopinke, Frank-Dieter, Oller, I., Malato, S., Gonzalez-Olmos, Rafael, Martin, M.J., Georgi, Anett, Kopinke, Frank-Dieter, Oller, I., and Malato, S.

Abstract

This paper focuses on the study of photo-Fenton-like processes using two types of Fe-zeolites (Fe-ZSM5 and Fe-Beta) as heterogeneous catalysts in order to treat contaminated effluents with organic compounds at neutral pH. It was proved that light (solar and artificial) improves significantly the DOC removal in this kind of processes. A possible contribution by homogeneous photo-Fenton reaction catalyzed by the iron leached during the reaction was insignificant. This study also proves that the catalytic activity of Fe-zeolites is improved by photo Fenton-like processes using solar light in a pilot plant equipped with compound parabolic collectors (CPC).

Published
2012

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