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Introduction: Non-communicable diseases are the global disease burden of our time, with physical inactivity identified as one major risk factor. Green spaces are associated with increased physical activity of nearby residents. But there are still gaps in understanding which proximity and what characteristics of green spaces can trigger physical activity. This study aims to unveil these differences with a rigorous sensitivity analysis. Methods: We gathered data on self-reported health and physical activity from 1365 participants in selected neighbourhoods in Porto, Nantes, Sofia, and Høje-Taastrup. Spatial data were retrieved from OpenStreetMap. We followed the PRIGSHARE guidelines to control for bias. Around the residential addresses, we generated seven different green space indicators for 15 distances (100–1500 m) using the AID-PRIGSHARE tool. We then analysed each of these 105 green space indicators together with physical activity and health in 105 adjusted structural equation models. Results: Green space accessibility and green space uses indicators showed a pattern of significant positive associations to physical activity and indirect to health at distances of 1100 m or less, with a peak at 600 m for most indicators. Greenness in close proximity (100 m) had significant positive effects on physical activity and indirect effects on health. Surrounding greenness showed positive direct effects on health at 500–1100 m and so do green corridors in 800 m network distance. In contrast, a high quantity of green space uses, and surrounding greenness measured in a larger radius (1100–1500 m) showed a negative relationship with physical activity and indirect health effects. Conclusions: Our results provide insight into how green space characteristics can influence health at different scales, with important implications for urban planners on how to integrate accessible green spaces into urban structures and public health decision-makers on the ability of green spaces to c, Heritage & Architecture, Environmental Technology and Design

Studies showed that stigma has implications for implementing, supporting, and accepting policies introduced to mitigate the issues associated with sex work, the oldest profession, in different countries and cultures worldwide. Here, we determined the level of social stigma across three living generations of Filipinos and their readiness for the possibility of decriminalizing the oldest profession in the Philippines using research-made survey questionnaires deliberately validated by Psychometricians. Respondents across three generations of Filipinos, namely, Generation Z, millennials, and Generation X, were gathered. The results showed a high level of social stigma towards sex work across the generations and a high level of readiness toward decriminalizing sex work. However, there is a noticeable difference in the levels of social stigma and readiness among the respondents. Generation x showed the highest level of social stigma towards sex work, while Generation Z showed the lowest level of social stigma. On the readiness towards decriminalizing sex work, Generation Z showed the highest level, while Generation X showed the lowest level among the respondents.   Analysis of this data showed no relationship between generational difference and readiness towards decriminalizing sex work. However, mediation analysis resulted in a positive outcome showing that social stigma is a mediator in the relationship between generational difference and readiness towards decriminalizing sex work. This implies that social stigma towards sex work can impact an individual's readiness regardless of age or generation. Contrary to the idea that older people could be more resistant to decriminalizing sex work and younger people more open to this idea, this research shows that regardless of age or generation, a person can be ready or not ready to accept this change depending on their level of social stigma associated towards sex work.&nbsp

Fungi and laccase mediator systems (LMSs) have a proven track record of oxidizing recalcitrant organic compounds. There has been considerable interest in applying LMSs to the treatment of perfluoroalkyl acids (PFAAs), a class of ubiquitous and persistent environmental contaminants. Some laboratory experiments have indicated modest losses of PFAAs over extended periods, but there have been no clear demonstrations of a transformation mechanism or the kinetics that would be needed for remediation applications. We set out to determine if this was a question of identifying and optimizing a rate-limiting step but discovered that observed losses of PFAAs were experimental artifacts. While unable to replicate the oxidation of PFAAs, we show that interactions of the PFAA compounds with laccase and laccase mediator mixtures could cause an artifact that mimics transformation (≲60%) of PFAAs. Furthermore, we employed a surrogate compound, carbamazepine (CBZ), and electron paramagnetic resonance spectroscopy to probe the formation of the radical species that had been proposed to be responsible for contaminant oxidation. We confirmed that under conditions where sufficient radical concentrations were produced to oxidize CBZ, no PFAA removal took place.

Purpose: This paper empirically demonstrates the major organizational events of a rolling forecasting process and the roles of controllers therein. In particular, this study aims to investigate how the understanding of a “realistic forecast” is translated and questioned by various mediators in the rolling forecasting process and how it affects the quality of planning as the ultimate accuracy of forecasts is seen as important. Design/methodology/approach: This study follows an actor-network theory (ANT) approach and maps the key points of translation in the rolling forecasting process by inspecting the roles of mediators. This qualitative case study is based on interviews with controllers and managers involved in the forecasting process in a single manufacturing company. Findings: The paper identified two episodes of translation in the forecasting process, in which the forecast partially stabilized to create room for managerial discussion and debate. The abilities of controllers to infiltrate various functional groups and calculative practices appeared to be one way to control the accuracy of forecasting, although this was built on a façade of neutrality. Originality/value: Prior literature identifies the aims of interactive planning processes as being to improve the quality of planning. The authors apply ANT to better understand the nature of mediators in constructing an entity called a “realistic rolling forecast”.

Objective: the purpose of this study is to consider the essence of mediation in criminal proceedings and determine its characteristics in the foreign legal system to improve national legislation.   Theoretical framework: theoretical materials were based on international scientific publications, reports, and scientific papers. And also for a more complete and objective presentation of the problem being studied, practical materials from criminal cases were used.   Method: is a dialectical method of understanding general patterns and particular manifestations of the essence of phenomena of objective reality. The comparative legal method made it possible to qualitatively study foreign legislation from the point of view of legal regulation of mediation in criminal proceedings, especially the experience of France, and in this regard, implement it into national legislation. The logical method made it possible to analyze the mechanism for implementing mediation in criminal proceedings and identify its components that need improvement.   Results and conclusion: mediation relieves the parties from the formal procedures inherent in judicial proceedings, from coercion, without which the exercise of judicial power is unthinkable. The personal participation of the parties in resolving the dispute, their joint search for a way out of the conflict, awareness of the need to find a mutually acceptable condition within the framework of law while respecting the legitimate interests of each party allows them to appreciate the meaning and significance of the law in their everyday life, provides experience in lawful behavior and a legal way out of conflict situations.   Originality/value: the value of the study lies in the fact that, on the basis of theoretical and legal analysis and the study of practical experience, it seems possible to improve the mechanism for implementing mediation in criminal proceedings in national legislation.

In the urban and coastal region surrounding the Marmara Sea, a detachment between human life and the ocean is emerging that seems primarily caused by the consequences of post-industrial anthropogenic processes. The effects are seen in the form of a mucilage plague in the waters, posing a threat to marine life, and thereby emphasizing the urgent need for intervention. This project, strives to unveil the interplay between the natural dynamics of the Sea of Marmara and our human relationship with this vital, pulsating ecosystem. At its core, the architectural intervention proposes a symbiotic architecture, positioning itself as a mediator that is bridging the widening gap between humanity and nature: An eco-centric approach that dissolves the conventional demarcation lines between land and water. By showcasing the various activities occurring in our oceans, the project seeks to enhance the visible connection and experience, developing a strengthened collective awareness of the ecological body we are part of. A carefully curated journey through an architectural landscape aims to create a deeper understanding of the interconnectedness and cyclical rhythms inherent to the surrounding landscape. Drawing from the insights of J. Bloomer, who challenges the conventional notion of coastlines as mere edges, the project embraces the concept of interrelational edge zones. Here, the terrain is seen not as a binary transition but as a dynamic and continuous process. In essence, the project aspires to not only address the immediate ecological concerns surrounding the Marmara Sea but also to spark a shift in our collective consciousness. By connecting architectural innovation with ecological principles, it strives to establish a harmonious co-existence between humans and the natural world, fostering a deep ecological awareness that transcends traditional boundaries., Architecture, Urbanism and Building Sciences | Borders and Territories

Water is the elixir of life for London, the river Thames is the heart powering its growth. Although it has created the existence of London, it has mainly been the city that influenced the river in route, form and function aligning with their needs. There always has been a changing tension between city and river, a battle between the forces of nature and the power of the anthropogenic. The combined impact of rapid urbanization and climate change has resulted in numerous shortcomings in the control-focused approach to urban river engineering and planning. Repeated flooding, environmental deterioration, biodiversity loss, declining livability, and increased environmental stress are all indicators of the diminished harmony between rivers and cities. These unintended side effects are a product of neglect, denial, and arrogance of not recognizing the river and its ecology. Therefore, there is an urgent need to rethink the Thames waterfront towards a justification for its existence and help regenerate both the river and the urban collective towards a coexisting future. This thesis explores the changing meaning of water and the riverfront in London today, accompanied by an overview and understanding of the various waterfront conditions along the Thames. Based upon that knowledge a strategy was made to (re-) connect humans and rivers through the use of architecture as a riparian mediator. The combination of the “third generation city” theory by Marco Casagrande and the “oligopticon” theory by Bruno Latour provided a powerful framework for developing an architectural typology that focuses on connecting humans and the non-human, while simultaneously regenerating the ecosystem. As the architecture had to be further defined the strategy continued upon the idea of negotiating boundaries. Not only between humans and non-humans, as already established, but also between form and fluidity, between architecture and landscape, and between program and regeneration for humans a, Architecture, Urbanism and Building Sciences | Architectural Design Crossovers

Los juzgados de violencia sobre la mujer, adoptan una doble vertiente, ya que además de ventilarse en ellos la responsabilidad penal, actuando como juzgados de instrucción de violencia, y celebrando los juicios por delitos leves de su competencia, también actúan como juzgados civiles, en relación al matrimonio/pareja y familia, en el ámbito civil. De ahí la extraordinaria complejidad e importancia de la materia civil, por cuanto resuelve la situación de la pareja/familia, a nivel personal, social y económico, y pese a ello sigue siendo “la gran olvidada” en su desarrollo y medidas reales de apoyo. Por medio de este proyecto de tesis se ha investigado a través de un enfoque derivado del estudio de la normativa legal tanto sustantiva como procedimental y del conocimiento de la situación real y práctica de los juzgados, el complejo mundo familiar en violencia de género, sin dejar de lado el cada vez más importante aspecto internacional de la violencia, y el importante enfoque del interés superior del menor. Todo ello con la finalidad de obtener una visión general, realista y comprometida, de la pareja/ familia que se encuentra inmersa en un procedimiento en los juzgados de violencia de género, y precisamente por ello, se convierte en punto central la defensa de la mediación también en estos casos. Un estudio profundo de ésta, supone concluir que privar de este mecanismo en los casos afectados por violencia de género, mediante una prohibición absoluta, supone un perjuicio personal, familiar y en general para toda la sociedad.

Medling vid brott är en konflikthanteringsmetod där brottsutsatt och gärningsperson möts tillsammans med en opartisk medlare för att tala om brottet, dess konsekvenser och framtiden. Medling är en del av rättssystemet och ett komplement till den ordinarie rättsprocessen och omgärdas av en egen lagstiftning sedan 2002. Lagen avser främst unga lagöverträdare och kommunerna är sedan 2008 skyldiga att kunna erbjuda medling till unga under 21 år. Syftet med medling är såväl brossförebyggande som gynnande för båda parter. Den brottutsatte ska genom att möta gärningspersonen i ett medlingsmöte kunna bearbeta sina upplevelser av brottet. Gärningspersonen ska få insikt i vilka konsekvenserna varit för den utsatte. Medling kan genomföras vid alla slags brott om det anses lämpligt i det enskilda fallet.

Medling tycks vara en outnyttjad resurs i sverige trots lagstiftning inom vissa medlingsområden. Det saknas nationell samordning, trots reglering inom vissa medlingsområden. Det finns behov av ytterligare reglering, krav på utbildning, metodutveckling och kvalitetssäkring. Barnet som rättssubjekt behöver också diskuteras vidare. Frivillighet anses vara en förutsättning för en framgångsrik medling, men frivililligheten i den praktiska verksamheten kan i vissa fall ifrågaasättas. En fördjupad kunskap om medlingens effekter samt när medling är lämpligt respektive mindre lämpligt saknas. Det finns behov av fortsatt forskning inom de olika medlingsområden som boken behandlar samt ett större samhälleligt och politiskt intresse.

[spa] El contexto global en el que vivimos ha puesto en una encrucijada al sistema judicial. A nivel internacional, los Estados convergen en la necesidad de dotar a la Administración de Justicia de una nueva estructura que la vuelva eficiente en aras de recuperar la confianza de los ciudadanos. En este sentido, el multi-door courthouse se presenta como el nuevo paradigma del presente siglo porque da respuesta a las actuales necesidades sociales y jurídicas. Realizamos un recorrido por el origen histórico del concepto, su evolución, características y trascendencia actual. Pasamos entonces a explicar el recibimiento, en la Unión Europea, del movimiento que envuelve este modelo y el especial interés que le prestan las instituciones comunitarias a la relación entre los tribunales y la mediación. Esta coyuntura nos ayudará a comprender el marco legislativo en España e intuiremos si el sistema multipuerta es una posibilidad en el futuro próximo., [eng] The judicial system stands today at a crossroads due to the contemporary global context. At the international level, states are faced with the need to give a new structure to their Administration of Justice, making it efficient in order to regain the trust of citizens. In this regard, the multi-door courthouse appears to be the new paradigm of this century since it meets current social and legal needs. We make a journey that begins by explaining the historical origin of the concept, its evolution, characteristics and current significance. Then we go on to explain the reception, in the European Union, of the movement involving this model and the special interest devoted by the European institutions to the relationship between courts and mediation. This juncture will help us to understand the Spanish legislative framework and we will intuit whether the multi-door system is a possibility in the foreseeable future.

Reinforcement learning (RL) has grown tremendously over one and a half decades and is increasingly emerging in many real-life applications. However, the application of RL is still limited due to its low training efficiencies and surplus training cost. The sampling and computation complexity normally depends on the size of the state space and splitting the state space can distribute computation and accelerate learning. State abstraction as a form of data-centric method shrinks the state space and reduces learning time, however, it is challenged by the fact that abstraction throws away information and might result in a sub-optimal solution. In this thesis, we propose the hierarchical clustering-based state grouping (HCSG) method to split the ground state space into clusters and train multiple agents for each cluster without changing the dimension of the state space. This approach allows us to distribute computation and improves training efficiency without losing the overall performance, and was also shown to outperform baseline and other state-of-art data-centric methods., MEDIATOR Project, Electrical Engineer | Embedded Systems

Sustainable building design practices are influenced by requirements, guidelines, criteria for green procurement and certification, assessment tools such as life cycle assessment, etc. This study investigates how such artefacts support or define aspirations towards sustainability, through case studies of public housing projects in Sweden and Cyprus. The study first illustrates how constraints mediated by artefacts set boundaries to the range of available sustainable design options. On one hand, fulfilling sustainability requirements conveyed in regulations, certifications and directives is a major driver of designers' involvement with sustainable design. On the other hand, cost calculations, procurement laws and development plans exclude certain design options. Moreover, default solutions and standardised design guidelines within the organisation streamline and simplify the design process, indirectly determining what sustainable design options are considered. However, these demands and default options are also bent and adapted on a case-by-case basis. The ways in which sustainable design arises from the interplay between artefacts and actors' agency differed significantly between the Swedish and Cypriot cases. Swedish actors' operational definition of sustainability is strongly codified and enforced through inter-connected artefacts. The Miljo center dot byggnad certification is often a de facto definition of sustainability used by actors to set sustainability criteria and targets. Environmental databases for construction products act as black boxes, implicitly determining what aspects of sustainability are addressed in design decisions. Conversely, Cypriot designers' work with sustainability depends to a larger extent on their motivation, experience and ability to convince their peers., QC 20221024

A reflective assessment of teaching praxis’ notions and beliefs becomes essential in instructing learners to effectively interact in intercultural encounters. Arguments in favor of teaching the intercultural component have been promoted for years but have not fully reached systematic incorporation in foreign language education in Latin American countries. This paper examines the concept of the intercultural mediator, approaching key questions (why, what, and how) that emerge when integrating intercultural objectives in the language classroom supported on theoretical frameworks and insights from the authors’ teaching experience. The methodology used was an exploratory qualitative document review. Scientific articles published in reliable databases were consulted to answer the questions targeting intercultural communicative competence teaching. The main objective is to invigorate the discussion regarding the intercultural component in the classroom while exploring practical ideas to teach it. Findings suggest that there is a growing body of literature and interest on approaching theoretical and practical standpoints toward ICC guiding teachers to become intercultural educators willing to integrate and enable learners with the crucial ICC competence. Educators can make a difference in the classroom by utilizing different Latin American resources and material to mediate intercultural matters in the foreign language classroom., Uma avaliação reflexiva das noções e crenças sobre a práxis docente é essencial para instruir os alunos com as habilidades necessárias para uma interação efetiva em encontros interculturais. Os argumentos a favor do ensino do componente intercultural são promovidos há anos, mas não alcançaram uma incorporação sistemática no ensino de línguas estrangeiras nos países latino-americanos. Este artigo examina o conceito de educador como mediador intercultural, abordando as questões-chave (por que, o quê e como) que emergem ao integrar objetivos interculturais na sala de aula de línguas. A metodologia utilizada foi uma revisão documental qualitativa exploratória. Foram consultados artigos científicos publicados em bases de dados confiáveis ​​para responder às questões referentes ao ensino da competência comunicativa intercultural. O principal objetivo é dinamizar o debate sobre a componente intercultural na sala de aula e oferecer aos educadores ideias práticas sobre como atingir esse objetivo. Os resultados sugerem que há uma crescente literatura e interesse em envolver os alunos com competência intercultural crucial, oferecendo insights sobre como os educadores podem usar construções teóricas e práticas para se tornarem educadores interculturais. Os educadores podem fazer a diferença na sala de aula usando diferentes recursos e materiais latino-americanos para mediar questões interculturais na sala de aula de língua estrangeira., Una evaluación reflexiva de las nociones y creencias sobre la praxis docente es esencial para instruir a los alumnos con las habilidades necesarias para la interacción efectiva en encuentros interculturales. Los argumentos a favor de la enseñanza del componente intercultural han sido promovidos durante años, pero no han alcanzado una incorporación sistemática en la enseñanza de lenguas extranjeras en países latinoamericanos. Este trabajo examina el concepto del educador como mediador intercultural, abordando las preguntas claves (por qué, qué y cómo) emergentes al integrar objetivos interculturales en el aula de idiomas. La metodología utilizada fue una revisión documental cualitativa exploratoria. Se consultaron artículos científicos publicados en bases de datos fiables para responder a las preguntas en relación a la enseñanza de la competencia comunicativa intercultural. El objetivo principal es dinamizar el debate sobre el componente intercultural en el aula y ofrecer a los educadores ideas prácticas sobre cómo lograr ese objetivo. Los resultados sugieren que existe un incremento de la literatura e interés sobre la implicación de los alumnos con la crucial competencia intercultural, lo cual ofrece ideas sobre cómo los educadores pueden utilizar constructos teóricos y prácticos para convertirse en educadores interculturales. Los educadores pueden marcar la diferencia en el aula utilizando diferentes recursos y materiales Latinoamericanos para mediar asuntos interculturales en el aula de idiomas extranjeros.

Even though they represent almost 50% of all reported cases before the European Court of Human Rights, settlements of human rights violations escape scholars’ attention. Whilst victims are increasingly expected to resolve their disputes amicably, it is unclear whether applicants will be better off accepting settlement offers rather than proceeding to litigation. The paper charts the practice of friendly settlements before the Court from 1980s to today, mapping a shift in approach from seeking bilateral solutions to the proactive role of the Registry as mediator encouraging states and applicants to settle their cases to relieve the Court of the heavy workload. The study of 10,500 cases reveals how strategies adopted by the Registry – from procedural changes to how and when consent is given to settlement, to the framing of settlement offers and a close relationship with representatives of the respondent state – have favoured the most frequent violators of the Convention and sidelined the interests of the applicant. The analysis uncovers that the imbalance between parties and lack of enforcement are very much present in the ECtHR settlement system and that the active role of the Registry has reinforced, rather than redressed these concerns. The findings expose the dangers of pursuing en masse settlement in the human rights context and raise concerns about achieving long-term justice for victims of human rights violations through other means than adjudication.

Even though they represent almost 50% of all reported cases before the European Court of Human Rights, settlements of human rights violations escape scholars’ attention. Whilst victims are increasingly expected to resolve their disputes amicably, it is unclear whether applicants will be better off accepting settlement offers rather than proceeding to litigation. The paper charts the practice of friendly settlements before the Court from 1980s to today, mapping a shift in approach from seeking bilateral solutions to the proactive role of the Registry as mediator encouraging states and applicants to settle their cases to relieve the Court of the heavy workload. The study of 10,500 cases reveals how strategies adopted by the Registry – from procedural changes to how and when consent is given to settlement, to the framing of settlement offers and a close relationship with representatives of the respondent state – have favoured the most frequent violators of the Convention and sidelined the interests of the applicant. The analysis uncovers that the imbalance between parties and lack of enforcement are very much present in the ECtHR settlement system and that the active role of the Registry has reinforced, rather than redressed these concerns. The findings expose the dangers of pursuing en masse settlement in the human rights context and raise concerns about achieving long-term justice for victims of human rights violations through other means than adjudication.

Acute and chronic inflammation is a basic pathological event that contributes to atherosclerosis, cancer, infectious diseases, and immune disorders. Inflammation is an adaptive process to both external and internal stimuli experienced by the human body. Although the mechanism of gene transcription is highly complicated and orchestrated in a timely and spatial manner, recent developments in next-generation sequencing, genome-editing, cryo-electron microscopy, and single cell-based technologies could provide us with insights into the roles of super enhancers (SEs). Initially, SEs were implicated in determining cell fate; subsequent studies have clarified that SEs are associated with various pathological conditions, including cancer and inflammatory diseases. Recent technological advances have unveiled the molecular mechanisms of SEs, which involve epigenetic histone modifications, chromatin three-dimensional structures, and phase-separated condensates. In this review, we discuss the relationship between inflammation and SEs and the therapeutic potential of SEs for inflammatory diseases.

[spa] El contexto global en el que vivimos ha puesto en una encrucijada al sistema judicial. A nivel internacional, los Estados convergen en la necesidad de dotar a la Administración de Justicia de una nueva estructura que la vuelva eficiente en aras de recuperar la confianza de los ciudadanos. En este sentido, el multi-door courthouse se presenta como el nuevo paradigma del presente siglo porque da respuesta a las actuales necesidades sociales y jurídicas. Realizamos un recorrido por el origen histórico del concepto, su evolución, características y trascendencia actual. Pasamos entonces a explicar el recibimiento, en la Unión Europea, del movimiento que envuelve este modelo y el especial interés que le prestan las instituciones comunitarias a la relación entre los tribunales y la mediación. Esta coyuntura nos ayudará a comprender el marco legislativo en España e intuiremos si el sistema multipuerta es una posibilidad en el futuro próximo., [eng] The judicial system stands today at a crossroads due to the contemporary global context. At the international level, states are faced with the need to give a new structure to their Administration of Justice, making it efficient in order to regain the trust of citizens. In this regard, the multi-door courthouse appears to be the new paradigm of this century since it meets current social and legal needs. We make a journey that begins by explaining the historical origin of the concept, its evolution, characteristics and current significance. Then we go on to explain the reception, in the European Union, of the movement involving this model and the special interest devoted by the European institutions to the relationship between courts and mediation. This juncture will help us to understand the Spanish legislative framework and we will intuit whether the multi-door system is a possibility in the foreseeable future.

Reinforcement learning (RL) has grown tremendously over one and a half decades and is increasingly emerging in many real-life applications. However, the application of RL is still limited due to its low training efficiencies and surplus training cost. The sampling and computation complexity normally depends on the size of the state space and splitting the state space can distribute computation and accelerate learning. State abstraction as a form of data-centric method shrinks the state space and reduces learning time, however, it is challenged by the fact that abstraction throws away information and might result in a sub-optimal solution. In this thesis, we propose the hierarchical clustering-based state grouping (HCSG) method to split the ground state space into clusters and train multiple agents for each cluster without changing the dimension of the state space. This approach allows us to distribute computation and improves training efficiency without losing the overall performance, and was also shown to outperform baseline and other state-of-art data-centric methods., MEDIATOR Project, Electrical Engineering | Embedded Systems

Introduction Anxiety and depressive disorders are a significant problem that starts in childhood or adolescence and should be addressed early to avoid chronic mental conditions. There is strong evidence to demonstrate that psychological treatments are effective for these disorders, however, little is known on mediators and mechanisms of change of psychological treatment in adolescents and young adults. Understanding the pathways through which psychological treatments operate will facilitate more effective treatments. Aim We aim to conduct a systematic review, exploring the available evidence on mediators of psychological treatments for anxiety and depression in adolescents and young adults. Methods A systematic search has been performed on PubMed and PsycINFO databases to identify studies from inception to 23rd February 2020. Eligible studies include randomized controlled trials and trials (quasi-experimental) designs that have enrolled adolescents and young adults presenting with depression and/or anxiety and that have examined mediators of psychological treatments. A group of 20 reviewers from the COST-Action TREATme (CA16102) divided into 10 pairs independently screen studies for inclusion, extract information from the included studies, and assess the methodological quality of the included studies and the requirements for mediators. The methodological quality will be assessed by The Mixed Methods Appraisal Tool. Extracted data from the included studies will be collected and presented using a narrative approach. Discussion This systematic review will summarize and provide a comprehensive overview of the current evidence on mediators of psychological treatments for anxiety and depression for adolescents and young adults. Results will allow the identification of strategies to optimize intervention to enhance clinical outcomes. Ethics and dissemination Ethics approval is not required. Findings from this systematic review will be published in a peer-reviewed journal a

This article examines project activity as one of the most important methods in the system of professional training of guide- ranslators in the process of teaching a foreign language. The main methods for the implementation of project activities in the educational process are system-activity and communicative methods. The project activity is implemented on the basis ofcompliance with a number of requirements and has a certain sequence of actions. The article presents the classification of projects, describes the main requirements for the implementation of projects.

The development of criminal justice in recent decades has been characterized not only by the fight against crime, but also by the search for the most effective mechanisms to achieve other critical goals. The resolution of criminal disputes arising as a result of the commission of an illegal act by a person [1] includes such aspects as compensation for the damage caused to the person who committed the act, the restoration of the violated order. as a result of the crime, the restoration of the normal life of the victim after the commission of the crime, the re-socialization of the convict in order to prevent the recurrence of the crime, and so on. This article conducts a small amount of research on mediation issues in criminal proceedings

This article examines project activity as one of the most important methods in the system of professional training of guide- ranslators in the process of teaching a foreign language. The main methods for the implementation of project activities in the educational process are system-activity and communicative methods. The project activity is implemented on the basis ofcompliance with a number of requirements and has a certain sequence of actions. The article presents the classification of projects, describes the main requirements for the implementation of projects.

This article examines project activity as one of the most important methods in the system of professional training of guide- ranslators in the process of teaching a foreign language. The main methods for the implementation of project activities in the educational process are system-activity and communicative methods. The project activity is implemented on the basis ofcompliance with a number of requirements and has a certain sequence of actions. The article presents the classification of projects, describes the main requirements for the implementation of projects.

This article examines project activity as one of the most important methods in the system of professional training of guide- ranslators in the process of teaching a foreign language. The main methods for the implementation of project activities in the educational process are system-activity and communicative methods. The project activity is implemented on the basis ofcompliance with a number of requirements and has a certain sequence of actions. The article presents the classification of projects, describes the main requirements for the implementation of projects.

The development of criminal justice in recent decades has been characterized not only by the fight against crime, but also by the search for the most effective mechanisms to achieve other critical goals. The resolution of criminal disputes arising as a result of the commission of an illegal act by a person [1] includes such aspects as compensation for the damage caused to the person who committed the act, the restoration of the violated order. as a result of the crime, the restoration of the normal life of the victim after the commission of the crime, the re-socialization of the convict in order to prevent the recurrence of the crime, and so on. This article conducts a small amount of research on mediation issues in criminal proceedings

This article examines project activity as one of the most important methods in the system of professional training of guide- ranslators in the process of teaching a foreign language. The main methods for the implementation of project activities in the educational process are system-activity and communicative methods. The project activity is implemented on the basis ofcompliance with a number of requirements and has a certain sequence of actions. The article presents the classification of projects, describes the main requirements for the implementation of projects.

This article examines project activity as one of the most important methods in the system of professional training of guide- ranslators in the process of teaching a foreign language. The main methods for the implementation of project activities in the educational process are system-activity and communicative methods. The project activity is implemented on the basis ofcompliance with a number of requirements and has a certain sequence of actions. The article presents the classification of projects, describes the main requirements for the implementation of projects.

This article examines project activity as one of the most important methods in the system of professional training of guide- ranslators in the process of teaching a foreign language. The main methods for the implementation of project activities in the educational process are system-activity and communicative methods. The project activity is implemented on the basis ofcompliance with a number of requirements and has a certain sequence of actions. The article presents the classification of projects, describes the main requirements for the implementation of projects.

For many years, epidemiologists were mainly focused on the estimation of exposure-outcome effects. Nowadays, epidemiologists are also interested in assessing the causal mechanisms underlying exposure-outcome effects. Mediation analysis can be used to gain insight in these causal mechanisms, as it decomposes the total exposure-outcome effect into a direct effect and an indirect effect through a mediator. Traditionally, mediation analysis is performed based on a sequence of three linear regression equations. Subsequently, the indirect effect is estimated based on the product-of-coefficients estimator or the difference-in-coefficients estimator. In recent years, causal mediation analysis gained in popularity. Causal mediation analysis is based on the potential outcomes framework and counterfactual framework and defines the direct, indirect, and total effect as the difference between two potential outcomes. There are some important differences between traditional and causal mediation analysis. Traditional mediation analysis does not incorporate exposure-mediator interaction in its effect definitions while causal mediation analysis does incorporate exposure-mediator interaction in its effect definitions. Another important difference between traditional and causal mediation analysis is that the causal effect definitions are not dependent on a specific estimation method, while the traditional effects are defined and estimated based on (linear) regression coefficients. The causal effect definitions can therefore be applied to any mediation model, and do not necessarily depend on parametric assumptions. Based on these differences between traditional and causal mediation analysis, the question arises when and why the effect estimates from these two methods are the same or different. The aim of this thesis is to assess the similarities and differences in the effect estimates yielded by traditional mediation analysis and causal mediation analysis for mediation models frequently

To help to clarify the concept of «expiation» this article seeks to trace its main elements in the Old Testament’s theology. After an overview of the uses of the term in the Old Testament we focus on the expiation in the priestly document (where it is understood in the context of ritual sacrifices) and then on its intercessory dimension, with a special focus on the mediation of the Deuteroisaiah’s servant of Yahweh. We conclude that expiation is a relational process in which God removes evil from the human being and enables reconciliation (with the person’s participation and normally with a mediator)., Para ayudar a clarificar el concepto de «expiación» este artículo busca rastrear sus principales elementos en la teología veterotestamentaria. Tras una panorámica de los usos del término en el Antiguo Testamento nos centramos en la expiación en el documento sacerdotal (donde es entendida en el marco de los sacrificios rituales) y después en su dimensión intercesora, con un especial detenimiento en la mediación del siervo de Yahveh del Deuteroisaías. Concluimos que la expiación es un proceso relacional en el que Dios borra el mal del ser humano y posibilita la reconciliación (con la participación de la persona y normalmente de un mediador).

The development of criminal justice in recent decades has been characterized not only by the fight against crime, but also by the search for the most effective mechanisms to achieve other critical goals. The resolution of criminal disputes arising as a result of the commission of an illegal act by a person [1] includes such aspects as compensation for the damage caused to the person who committed the act, the restoration of the violated order. as a result of the crime, the restoration of the normal life of the victim after the commission of the crime, the re-socialization of the convict in order to prevent the recurrence of the crime, and so on. This article conducts a small amount of research on mediation issues in criminal proceedings

This article examines project activity as one of the most important methods in the system of professional training of guide- ranslators in the process of teaching a foreign language. The main methods for the implementation of project activities in the educational process are system-activity and communicative methods. The project activity is implemented on the basis ofcompliance with a number of requirements and has a certain sequence of actions. The article presents the classification of projects, describes the main requirements for the implementation of projects.

There is now a consensus in the literature that future improvements in outcomes obtained from cognitive behavioral therapy (CBT) for chronic pain will require research to identify patient and treatment variables that help explain outcomes. The first aim of this study was to assess whether pre-treatment scores on measures of psychological (in)flexibility, acceptance, committed action, cognitive (de)fusion, and values-based action predict outcomes in a multidisciplinary, multicomponent, group-based CBT program for adults with chronic pain. The second aim was to assess whether change scores on these same measures mediate outcomes in the treatment program. Participants were 232 people attending treatment for chronic pain. Of the psychological flexibility measures, only pre-treatment scores on the psychological inflexibility scale predicted outcomes; higher scores on this measure were associated with worse outcomes. However, change scores on each of the psychological flexibility measures separately mediated outcomes. The efficacy of CBT for chronic pain may be improved with a greater focus on methods that increase psychological flexibility.

There is now a consensus in the literature that future improvements in outcomes obtained from cognitive behavioral therapy (CBT) for chronic pain will require research to identify patient and treatment variables that help explain outcomes. The first aim of this study was to assess whether pre-treatment scores on measures of psychological (in)flexibility, acceptance, committed action, cognitive (de)fusion, and values-based action predict outcomes in a multidisciplinary, multicomponent, group-based CBT program for adults with chronic pain. The second aim was to assess whether change scores on these same measures mediate outcomes in the treatment program. Participants were 232 people attending treatment for chronic pain. Of the psychological flexibility measures, only pre-treatment scores on the psychological inflexibility scale predicted outcomes; higher scores on this measure were associated with worse outcomes. However, change scores on each of the psychological flexibility measures separately mediated outcomes. The efficacy of CBT for chronic pain may be improved with a greater focus on methods that increase psychological flexibility.

There is now a consensus in the literature that future improvements in outcomes obtained from cognitive behavioral therapy (CBT) for chronic pain will require research to identify patient and treatment variables that help explain outcomes. The first aim of this study was to assess whether pre-treatment scores on measures of psychological (in)flexibility, acceptance, committed action, cognitive (de)fusion, and values-based action predict outcomes in a multidisciplinary, multicomponent, group-based CBT program for adults with chronic pain. The second aim was to assess whether change scores on these same measures mediate outcomes in the treatment program. Participants were 232 people attending treatment for chronic pain. Of the psychological flexibility measures, only pre-treatment scores on the psychological inflexibility scale predicted outcomes; higher scores on this measure were associated with worse outcomes. However, change scores on each of the psychological flexibility measures separately mediated outcomes. The efficacy of CBT for chronic pain may be improved with a greater focus on methods that increase psychological flexibility.

In this research, we aimed to establish a guideline for designing electron mediators suitable for biofuel cells. A redox potential simulator was fabricated by combining density functional theory calculation and experiment, allowing us to select molecules with appropriate redox potentials efficiently. Previously, mediators have been developed depending on the trials and errors; thus, our strategy will speed up the development of biofuel cells with outstanding performances.

Purpose: Trait anxiety, depressive symptoms, and cognitive complaints affect mental health. The mediating role of cognitive complaints has been reported recently. However, the mediating effects of cognitive complaints in the relationships between trait anxiety, depressive symptoms, and subjective well-being (SWB) and ill-being (SIB) remain unknown. Therefore, we used path analyses to investigate these mediating effects. Materials and Methods: A total of 554 adult community volunteers in Japan were studied using the State-Trait Anxiety Inventory (Form Y), Patient Health Questionnaire-9, Cognitive Complaints in Bipolar Disorder Rating Assessment, and Subjective Well-Being Inventory. These assessment tools evaluated trait anxiety, depressive symptoms, cognitive complaints, SWB, and SIB. Path analyses were performed in this study. Results: Path analyses revealed that there were significant indirect effects, via cognitive complaints, of trait anxiety and depressive symptoms on SIB. However, there were no significant indirect effects of trait anxiety and depressive symptoms on SWB. There were significant indirect effects, via depressive symptoms, of trait anxiety on cognitive complaints, SWB, and SIB. Conclusion: The role of cognitive complaints may be different between SWB and SIB associated with trait anxiety and depressive symptoms. Evaluating the mediating effect of cognitive complaints may be more useful on SIB than SWB associated with trait anxiety and depressive symptoms. These findings may be useful when considering intervention targets in mental health.

Complaints of cognitive functions (CCFs), defined as subjective cognitive dysfunction, affect social function; additionally, for workers, this condition is an important factor in presenteeism and mediates the effect of depressive symptoms on presenteeism. This study aimed to investigate whether CCFs mediate the relationships among insomnia, state anxiety (SA), and presenteeism. Participants were 471 Japanese adult workers evaluated using the Athens Insomnia Scale, State-Trait Anxiety Inventory (Form Y), Cognitive Complaints in Bipolar Disorder Rating Assessment, and Work Limitations Questionnaire 8 to assess insomnia, SA, CCFs, and presenteeism, respectively. Path analysis was used to evaluate the correlations between variables. CCFs significantly mediated the associations among insomnia, SA, and presenteeism. To address the presenteeism associated with insomnia and SA, it may be useful to assess the mediating roles of CCFs.

Indigo is one of the oldest natural blue dyes. Microorganisms and their enzymatic activities are deeply involved in the traditional indigo staining procedure. To elucidate the mechanism of the microbial indigo reduction, we directly performed cyclic voltammetry on alkaline fermenting dye suspensions. A pair of characteristic redox peaks of leuco-indigo was observed in a supernatant fluid of the fermenting dye suspension. On the other hand, it was found that the indigo/leuco-indigo redox couple mediated two-way microbially catalyzed oxidation and reduction in a sediment-rich suspension of the fermenting suspension. Acetaldehyde was supposed to be the electron donor and acceptor of the catalytic reactions. In order to verify the bioelectrocatalytic reaction, we isolated indigo-reducing bacterium K2-3′ from the fermenting suspension, and the two-way bioelectrocatalysis was successfully restaged in a model system containing K2-3′ and methyl viologen (as a soluble mediator instead of indigo) as well as acetaldehyde at pH 10.

Cognitive complaints, defined as perceived cognitive dysfunction in daily living, are associated with depressive symptoms. The associations of cognitive complaints and depressive symptoms with health-related quality of life (HRQoL) and perceived overall health in Japanese adults remains unknown. To investigate these relationships, we evaluated a convenience sample of 525 Japanese adult volunteers (Mage: 41.3 +/- 11.7; 238 male and 287 female). We used the Cognitive Complaints in Bipolar Disorder Rating Assessment (evaluating cognitive complaints), Patient Health Questionnaire-9 (evaluating depressive symptoms), EuroQol-5 Dimension-5 Level (EQ-5D-5L; evaluating HRQoL), and EuroQol-Visual Analogue Scale (EQ-VAS; evaluating perceived overall health). Our path analyses suggested that both cognitive complaints and depressive symptoms had significant total effects on HRQoL and perceived overall health. Furthermore, cognitive complaints were not significantly associated directly with HRQoL and perceived overall health, whereas cognitive complaints were significantly associated with HRQoL and perceived overall health indirectly via depressive symptoms. Depressive symptoms were significantly associated directly with HRQoL and perceived overall health. This study suggests that depressive symptoms may mediate the associations of cognitive complaints with HRQoL and perceived overall health. Thus, to address the HRQoL and perceived overall health associated with cognitive complaints, evaluation and intervention for depressive symptoms may be useful in public health.

Background In recent years, the roles of rumination, subjective cognitive impairment (SCI), and presenteeism have been emphasized in occupational mental health. However, associations between rumination, SCI, presenteeism, and psychological well-being are not fully understood. We hypothesized that SCI and presenteeism mediate the associations between rumination and subjective well-being (SWB) and subjective ill-being (SIB). Hence, we investigated the mediating roles of SCI and presenteeism in this study. Methods A total of 458 adult workers (mean age, 40.8 +/- 11.9 years; 44.1% male), who were recruited in Tokyo using convenience sampling, were analyzed in this study. The Ruminative Responses Scale, Cognitive Complaints in Bipolar Disorder Rating Assessment, Work Limitations Questionnaire 8, and Subjective Well-being Inventory were used to evaluate rumination, SCI, presenteeism, and psychological well-being (SWB and SIB), respectively. Path analyses were performed to evaluate the relations between these parameters. Results The path analysis indicated that rumination, SCI, and presenteeism were directly and negatively associated with SWB and SIB. Regarding indirect effects, rumination was negatively associated with SWB and SIB via SCI, presenteeism, and both SCI and presenteeism. Furthermore, SCI was negatively associated with SWB and SIB via presenteeism. Conclusions The results suggest that SCI and presenteeism mediate the associations of rumination with SWB and SIB in Japanese adult workers. To address the psychological well-being associated with rumination, evaluating SCI and presenteeism simultaneously may be useful in occupational mental health. This study provides key insights into the development of comprehensive intervention strategy based on the biopsychosocial perspective for worker's psychological well-being.

In the sphere of education, mediation and communication practices help not only to resolve disputes and conflicts most effectively but also to protect the interests of children and minors. The study aims to explore and analyze the effectiveness of mediation and communication practices in resolving conflicts in educational organizations, as well as identify trends in the development of this institution. The importance and role of using mediation and communication practices in conflict resolution in the sphere of education are analyzed and the theoretical aspects of the effectiveness of mediation in educational organizations are studied. The reasons for the emergence of conflicts in educational organizations are identified and the need to improve the effectiveness of mediation and communication practice implementation in conflict resolution in the sphere of education is substantiated. The study results allow outlining trends in the development of the studied institution. Further research can address the effectiveness of mediation and communication practices and the feasibility of using various methods and techniques to improve the use of mediation and communication skills in educational legal relations., Na esfera da educação, as práticas de mediação e comunicação ajudam não só a resolver disputas e conflitos de forma mais eficaz, mas também a proteger os interesses de crianças e menores. O estudo tem como objetivo explorar e analisar a eficácia das práticas de mediação e comunicação na resolução de conflitos nas organizações educacionais, bem como identificar tendências no desenvolvimento desta instituição. São analisados a importância e o papel do uso de práticas de mediação e comunicação na resolução de conflitos no âmbito da educação e estudados os aspectos teóricos da eficácia da mediação nas organizações educacionais. Identificam-se as razões para o surgimento de conflitos nas organizações educacionais e fundamenta-se a necessidade de melhorar a eficácia da implementação das práticas de mediação e comunicação na resolução de conflitos na esfera da educação. Os resultados do estudo permitem traçar tendências no desenvolvimento da instituição estudada. Pesquisas adicionais podem abordar a eficácia daspráticas de mediação e comunicação e a viabilidade do uso de vários métodos e técnicas para melhorar o uso de habilidades de mediação e comunicação nas relações jurídicas educacionais., En el ámbito de la educación, las prácticas de mediación y comunicación ayudan no solo a resolver disputas y conflictos de la manera más eficaz, sino también a proteger los intereses de los niños y los menores. El estudio tiene como objetivo explorar y analizar la efectividad de las prácticas de mediación y comunicación en la resolución de conflictos en las organizaciones educativas, así como identificar tendencias en el desarrollo de esta institución. Se analizala importancia y papel del uso de prácticas de mediación y comunicación en la resolución de conflictos en el ámbito educativo y se estudian los aspectos teóricos de la efectividad de la mediación en las organizaciones educativas. Se identifican los motivos del surgimiento de conflictos en las organizaciones educativas y se fundamenta la necesidad de mejorar la efectividad de la implementación de prácticas de mediación y comunicación en la resolución de conflictos en el ámbito educativo. Los resultados delestudio permiten esbozar tendencias en el desarrollo de la institución estudiada. La investigación adicional puede abordar la efectividad de las prácticas de mediación y comunicación y la viabilidad de usar varios métodos y técnicas para mejorar el uso delas habilidades de mediación y comunicación en las relaciones legales educativas.

There is now a consensus in the literature that future improvements in outcomes obtained from cognitive behavioral therapy (CBT) for chronic pain will require research to identify patient and treatment variables that help explain outcomes. The first aim of this study was to assess whether pre-treatment scores on measures of psychological (in)flexibility, acceptance, committed action, cognitive (de)fusion, and values-based action predict outcomes in a multidisciplinary, multicomponent, group-based CBT program for adults with chronic pain. The second aim was to assess whether change scores on these same measures mediate outcomes in the treatment program. Participants were 232 people attending treatment for chronic pain. Of the psychological flexibility measures, only pre-treatment scores on the psychological inflexibility scale predicted outcomes; higher scores on this measure were associated with worse outcomes. However, change scores on each of the psychological flexibility measures separately mediated outcomes. The efficacy of CBT for chronic pain may be improved with a greater focus on methods that increase psychological flexibility.

This article aims to analyze the possibilities of using systems of artificial intelligence systems in the mediation procedure. For its realization it is based on the distinction between mediation and electronic mediation, and between it and the one that uses artificial intelligence. The analysis is carried out from two perspectives, a) the replacement of the mediator’s figure by the system and b) the use of this system as an aid in the mediation process. It is concluded that these systems have technological limitations that affect the nature of the procedure and the main characteristics of this, so that the existence of fully automated procedures means a denaturation of this alternative dispute resolution mechanism, at least since the current development of the technology., El presente artículo tiene como objetivo analizar las posibilidades de uso de sistemas de inteligencia artificial en el procedimiento de mediación. Para su realización se parte de la distinción entre mediación y mediación electrónica, y entre esta y la que utiliza inteligencia artificial. El análisis se realiza desde dos perspectivas, a) la sustitución de la figura del mediador por el sistema y b) la utilización de este último como auxilio en el proceso de mediación. Se concluye que estos sistemas presentan limitaciones tecnológicas que inciden en la naturaleza del procedimiento por lo cual la existencia de procedimientos totalmente automatizados significaría su desnaturalización como mecanismo alternativo de resolución de controversias, al menos desde el actual desarrollo de la tecnología.

To help to clarify the concept of «expiation» this article seeks to trace its main elements in the Old Testament’s theology. After an overview of the uses of the term in the Old Testament we focus on the expiation in the priestly document (where it is understood in the context of ritual sacrifices) and then on its intercessory dimension, with a special focus on the mediation of the Deuteroisaiah’s servant of Yahweh. We conclude that expiation is a relational process in which God removes evil from the human being and enables reconciliation (with the person’s participation and normally with a mediator)., Para ayudar a clarificar el concepto de «expiación» este artículo busca rastrear sus principales elementos en la teología veterotestamentaria. Tras una panorámica de los usos del término en el Antiguo Testamento nos centramos en la expiación en el documento sacerdotal (donde es entendida en el marco de los sacrificios rituales) y después en su dimensión intercesora, con un especial detenimiento en la mediación del siervo de Yahveh del Deuteroisaías. Concluimos que la expiación es un proceso relacional en el que Dios borra el mal del ser humano y posibilita la reconciliación (con la participación de la persona y normalmente de un mediador).

Background In recent years, the roles of rumination, subjective cognitive impairment (SCI), and presenteeism have been emphasized in occupational mental health. However, associations between rumination, SCI, presenteeism, and psychological well-being are not fully understood. We hypothesized that SCI and presenteeism mediate the associations between rumination and subjective well-being (SWB) and subjective ill-being (SIB). Hence, we investigated the mediating roles of SCI and presenteeism in this study. Methods A total of 458 adult workers (mean age, 40.8 +/- 11.9 years; 44.1% male), who were recruited in Tokyo using convenience sampling, were analyzed in this study. The Ruminative Responses Scale, Cognitive Complaints in Bipolar Disorder Rating Assessment, Work Limitations Questionnaire 8, and Subjective Well-being Inventory were used to evaluate rumination, SCI, presenteeism, and psychological well-being (SWB and SIB), respectively. Path analyses were performed to evaluate the relations between these parameters. Results The path analysis indicated that rumination, SCI, and presenteeism were directly and negatively associated with SWB and SIB. Regarding indirect effects, rumination was negatively associated with SWB and SIB via SCI, presenteeism, and both SCI and presenteeism. Furthermore, SCI was negatively associated with SWB and SIB via presenteeism. Conclusions The results suggest that SCI and presenteeism mediate the associations of rumination with SWB and SIB in Japanese adult workers. To address the psychological well-being associated with rumination, evaluating SCI and presenteeism simultaneously may be useful in occupational mental health. This study provides key insights into the development of comprehensive intervention strategy based on the biopsychosocial perspective for worker's psychological well-being.

Cognitive complaints, defined as perceived cognitive dysfunction in daily living, are associated with depressive symptoms. The associations of cognitive complaints and depressive symptoms with health-related quality of life (HRQoL) and perceived overall health in Japanese adults remains unknown. To investigate these relationships, we evaluated a convenience sample of 525 Japanese adult volunteers (Mage: 41.3 +/- 11.7; 238 male and 287 female). We used the Cognitive Complaints in Bipolar Disorder Rating Assessment (evaluating cognitive complaints), Patient Health Questionnaire-9 (evaluating depressive symptoms), EuroQol-5 Dimension-5 Level (EQ-5D-5L; evaluating HRQoL), and EuroQol-Visual Analogue Scale (EQ-VAS; evaluating perceived overall health). Our path analyses suggested that both cognitive complaints and depressive symptoms had significant total effects on HRQoL and perceived overall health. Furthermore, cognitive complaints were not significantly associated directly with HRQoL and perceived overall health, whereas cognitive complaints were significantly associated with HRQoL and perceived overall health indirectly via depressive symptoms. Depressive symptoms were significantly associated directly with HRQoL and perceived overall health. This study suggests that depressive symptoms may mediate the associations of cognitive complaints with HRQoL and perceived overall health. Thus, to address the HRQoL and perceived overall health associated with cognitive complaints, evaluation and intervention for depressive symptoms may be useful in public health.

Complaints of cognitive functions (CCFs), defined as subjective cognitive dysfunction, affect social function; additionally, for workers, this condition is an important factor in presenteeism and mediates the effect of depressive symptoms on presenteeism. This study aimed to investigate whether CCFs mediate the relationships among insomnia, state anxiety (SA), and presenteeism. Participants were 471 Japanese adult workers evaluated using the Athens Insomnia Scale, State-Trait Anxiety Inventory (Form Y), Cognitive Complaints in Bipolar Disorder Rating Assessment, and Work Limitations Questionnaire 8 to assess insomnia, SA, CCFs, and presenteeism, respectively. Path analysis was used to evaluate the correlations between variables. CCFs significantly mediated the associations among insomnia, SA, and presenteeism. To address the presenteeism associated with insomnia and SA, it may be useful to assess the mediating roles of CCFs.