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6,512 results on '"Leone, A"'

1. High-risk HPV genotypes are associated with anal cytologic abnormalities but not with malignant histological lesions in a cohort of people with HIV (PWH)

Author: Squillace, N, Bernasconi, D, Cogliandro, V, Lapadula, G, Soria, A, Sabbatini, F, Colella, E, Rossi, M, Cappelletti, A, Spreafico, G, Tamburini, A, Leone, B, Malandrin, S, Cavallero, A, Di Lucia, A, Braga, M, Bonfanti, P, Bernasconi, DP, Tamburini, AM, Leone, BE, Squillace, N, Bernasconi, D, Cogliandro, V, Lapadula, G, Soria, A, Sabbatini, F, Colella, E, Rossi, M, Cappelletti, A, Spreafico, G, Tamburini, A, Leone, B, Malandrin, S, Cavallero, A, Di Lucia, A, Braga, M, Bonfanti, P, Bernasconi, DP, Tamburini, AM, and Leone, BE
Published: 2024

2. Exploring the administrative burden faced by hematologists: a comprehensive study in Italy

Author: Petruzzelli, D, Vignetti, M, Trasarti, S, Sportoletti, P, Della Torre, S, Cairoli, R, Leone, F, Pompilio, G, Gullì, M, Brown Hajdukova, E, Integlia, D, Petruzzelli, Davide, Vignetti, Marco, Trasarti, Stefania, Sportoletti, Paolo, Della Torre, Silvia, Cairoli, Roberto, Leone, Francesca Pia Chiara, Pompilio, Giuseppe, Gullì, Marco, Brown Hajdukova, Eva, Integlia, Davide, Petruzzelli, D, Vignetti, M, Trasarti, S, Sportoletti, P, Della Torre, S, Cairoli, R, Leone, F, Pompilio, G, Gullì, M, Brown Hajdukova, E, Integlia, D, Petruzzelli, Davide, Vignetti, Marco, Trasarti, Stefania, Sportoletti, Paolo, Della Torre, Silvia, Cairoli, Roberto, Leone, Francesca Pia Chiara, Pompilio, Giuseppe, Gullì, Marco, Brown Hajdukova, Eva, and Integlia, Davide
Abstract: Background: Administrative burdens have been identified as a major issue impacting patient care, professional practice, and the overall efficiency of healthcare systems. The aim of this study is to assess the administrative burden faced by Italian hematologists. Methods: A cross-sectional survey that included both closed-ended quantitative questions and open-ended free text answer options was administered to 1,570 hematologists working with malignancies and members of Italian GIMEMA Foundation – Franco Mandelli ONLUS and the Italian Linfomi Foundation (FIL). The survey was conducted online from May 24 to June 30, 2023. Descriptive statistics were computed for the quantitative data to clearly summarize the responses and descriptive analysis of free text responses was carried out. Results: Surveyed hematologists spend an average of 47.07% of their time on administrative tasks, with 63.22% (n = 110) of respondents reporting spending at least half of their time on these activities. More than half (57.47%, n = 100) reported that “Patient care” is the medical task most affected by a lack of time. Additionally, 55.17% (n = 96) reported experiencing burnout in the past 6 months, with filling out “Forms” being identified as the top contributing administrative task by 27.59% (n = 48) of respondents, followed by “Scheduling” (24.71%, n = 43) and “Managing IT system failures” (21.84%, n = 38). Nearly half of the surveyed hematologists (45.40%, n = = 79) identified patient care as the top priority requiring more time. Conclusions: The study confirms that the administrative workload of hematologists has a significant impact on patient care, communication, and burnout risk, reducing the time available for patient care, leading to exhaustion and concern about clinical errors.
Published: 2024

3. Use of generative pre-trained large language models to predict suicide risk on social media texts

Author: Leone, L., Leone, L., Leone, L., and Leone, L.
Published: 2024

4. The sequential antifracturative treatment: a meta-analysis of randomized clinical trials

Author: Fassio, A, Gatti, D, Biffi, A, Ronco, R, Porcu, G, Adami, G, Alvaro, R, Bogini, R, Caputi, A, Cianferotti, L, Frediani, B, Gonnelli, S, Iolascon, G, Lenzi, A, Leone, S, Michieli, R, Migliaccio, S, Nicoletti, T, Paoletta, M, Pennini, A, Piccirilli, E, Rossini, M, Brandi, M, Corrao, G, Tarantino, U, Fassio A., Gatti D., Biffi A., Ronco R., Porcu G., Adami G., Alvaro R., Bogini R., Caputi A. P., Cianferotti L., Frediani B., Gonnelli S., Iolascon G., Lenzi A., Leone S., Michieli R., Migliaccio S., Nicoletti T., Paoletta M., Pennini A., Piccirilli E., Rossini M., Brandi M. L., Corrao G., Tarantino U., Fassio, A, Gatti, D, Biffi, A, Ronco, R, Porcu, G, Adami, G, Alvaro, R, Bogini, R, Caputi, A, Cianferotti, L, Frediani, B, Gonnelli, S, Iolascon, G, Lenzi, A, Leone, S, Michieli, R, Migliaccio, S, Nicoletti, T, Paoletta, M, Pennini, A, Piccirilli, E, Rossini, M, Brandi, M, Corrao, G, Tarantino, U, Fassio A., Gatti D., Biffi A., Ronco R., Porcu G., Adami G., Alvaro R., Bogini R., Caputi A. P., Cianferotti L., Frediani B., Gonnelli S., Iolascon G., Lenzi A., Leone S., Michieli R., Migliaccio S., Nicoletti T., Paoletta M., Pennini A., Piccirilli E., Rossini M., Brandi M. L., Corrao G., and Tarantino U.
Abstract: Background: Subjects with a fragility fracture have an increased risk of a new fracture and should receive effective strategies to prevent new events. The medium-term to long-term strategy should be scheduled by considering the mechanisms of action in therapy and the estimated fracture risk.Objective: A systematic review was conducted to evaluate the sequential strategy in patients with or at risk of a fragility fracture in the context of the development of the Italian Guidelines.Design: Systematic review and meta-analysis.Data sources and methods: PubMed, Embase, and the Cochrane Library were investigated up to February 2021 to update the search of a recent systematic review. Randomized clinical trials (RCTs) that analyzed the sequential therapy of antiresorptive, anabolic treatment, or placebo in patients with or at risk of a fragility fracture were eligible. Three authors independently extracted data and appraised the risk of bias in the included studies. The quality of evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation methodology. Effect sizes were pooled in a meta-analysis using fixed-effects models. The primary outcome was the risk of refracture, while the secondary outcome was the bone mineral density (BMD) change.Results: In all, 17 RCTs, ranging from low to high quality, met our inclusion criteria. A significantly reduced risk of fracture was detected at (i) 12 or 24 months after the switch from romosozumab to denosumab versus placebo to denosumab; (ii) 30 months from teriparatide to bisphosphonates versus placebo to bisphosphonates; and (iii) 12 months from romosozumab to alendronate versus the only alendronate therapy (specifically for vertebral fractures). In general, at 2 years after the switch from anabolic to antiresorptive drugs, a weighted BMD was increased at the lumbar spine, total hip, and femoral neck site.Conclusion: The Task Force formulated recommendations on sequential therapy, which is the fi
Published: 2024

5. Prevalence and Trajectories of Post-COVID-19 Neurological Manifestations: A Systematic Review and Meta-Analysis

Author: Giussani, G, Westenberg, E, Garcia-Azorin, D, Bianchi, E, Khan, A, Allegri, R, Atalar, A, Baykan, B, Crivelli, L, Fornari, A, Frontera, J, Guekht, A, Helbok, R, Hoo, F, Kivipelto, M, Leonardi, M, Lopez Rocha, A, Mangialasche, F, Marcassoli, A, Acarli, A, Ozge, A, Prasad, K, Prasad, M, Sviatskaia, E, Thakur, K, Vogrig, A, Leone, M, Winkler, A, Giussani G., Westenberg E., Garcia-Azorin D., Bianchi E., Khan A. H. K. Y., Allegri R. F., Atalar A. C., Baykan B., Crivelli L., Fornari A., Frontera J. A., Guekht A., Helbok R., Hoo F. K., Kivipelto M., Leonardi M., Lopez Rocha A. S., Mangialasche F., Marcassoli A., Acarli A. N. O., Ozge A., Prasad K., Prasad M., Sviatskaia E., Thakur K., Vogrig A., Leone M. A., Winkler A. S., Giussani, G, Westenberg, E, Garcia-Azorin, D, Bianchi, E, Khan, A, Allegri, R, Atalar, A, Baykan, B, Crivelli, L, Fornari, A, Frontera, J, Guekht, A, Helbok, R, Hoo, F, Kivipelto, M, Leonardi, M, Lopez Rocha, A, Mangialasche, F, Marcassoli, A, Acarli, A, Ozge, A, Prasad, K, Prasad, M, Sviatskaia, E, Thakur, K, Vogrig, A, Leone, M, Winkler, A, Giussani G., Westenberg E., Garcia-Azorin D., Bianchi E., Khan A. H. K. Y., Allegri R. F., Atalar A. C., Baykan B., Crivelli L., Fornari A., Frontera J. A., Guekht A., Helbok R., Hoo F. K., Kivipelto M., Leonardi M., Lopez Rocha A. S., Mangialasche F., Marcassoli A., Acarli A. N. O., Ozge A., Prasad K., Prasad M., Sviatskaia E., Thakur K., Vogrig A., Leone M. A., and Winkler A. S.
Abstract: Introduction: The aim of this systematic review and meta-analysis was to evaluate the prevalence of thirteen neurological manifestations in people affected by COVID-19 during the acute phase and at 3, 6, 9 and 12-month followup time points. Methods: The study protocol was registered with PROSPERO (CRD42022325505). MEDLINE (PubMed), Embase, and the Cochrane Library were used as information sources. Eligible studies included original articles of cohort studies, case-control studies, cross-sectional studies, and case series with ≥5 subjects that reported the prevalence and type of neurological manifestations, with a minimum follow-up of 3 months after the acute phase of COVID-19 disease. Two independent reviewers screened studies from January 1, 2020, to June 16, 2022. The following manifestations were assessed: neuromuscular disorders, encephalopathy/altered mental status/delirium, movement disorders, dysautonomia, cerebrovascular disorders, cognitive impairment/dementia, sleep disorders, seizures, syncope/transient loss of consciousness, fatigue, gait disturbances, anosmia/hyposmia, and headache. The pooled prevalence and their 95% confidence intervals were calculated at the six pre-specified times. Results: 126 of 6,565 screened studies fulfilled the eligibility criteria, accounting for 1,542,300 subjects with COVID-19 disease. Of these, four studies only reported data on neurological conditions other than the 13 selected. The neurological disorders with the highest pooled prevalence estimates (per 100 subjects) during the acute phase of COVID-19 were anosmia/ hyposmia, fatigue, headache, encephalopathy, cognitive impairment, and cerebrovascular disease. At 3-month follow-up, the pooled prevalence of fatigue, cognitive impairment, and sleep disorders was still 20% and higher. At six- and 9-month follow-up, there was a tendency for fatigue, cognitive impairment, sleep disorders, anosmia/ hyposmia, and headache to further increase in prevalence. At 12-month follow-up
Published: 2024

6. Psychological predictors of attitudes and intention to eat insect-based food

Author: Vanutelli, M, Adorni, R, Luperini, A, Leone, P, D'Addario, M, Steca, P, Leone, PA, Vanutelli, M, Adorni, R, Luperini, A, Leone, P, D'Addario, M, Steca, P, and Leone, PA
Abstract: Background: According to the FAO, greenhouse gas emissions from agri-livestock activities represent 31% of human-related emissions, among the main culprits of the climate crisis. To overcome these problems, alternative foods, such as insect-based foods, are becoming widespread. However, the possibility of introducing them into eating habits often arouses adverse psychological reactions and mistrust. This study aimed to map attitudes towards insect-based foods and consumption intentions as a function of individual characteristics to capture the psychological predictors of a wary attitude towards them. Methods: A sample of 122 students completed an online questionnaire in the pilot study. The questionnaire collected information about sociodemographics, decision-making style, trust in science, food neophobia, the intention to consume insect-based foods, and explicit and automatic attitudes (Implicit Association Test) toward them. Linear regression models were performed to explore which sociodemographic and psychological variables represented the most effective predictors of attitudes and intention to consume insect-based foods. Findings: Preliminary findings suggested that food neophobia was the strongest predictor of explicit attitudes toward insect-based foods. The most significant predictors of intention to eat insect-based foods were food neophobia, trust in science, and gender (men showed a greater propensity to consume insect-based foods than women). Discussion: Consumers are forming their beliefs regarding novel foods in this historical phase in which they must pay particular attention to choosing sustainable foods. This study contributes to understanding people's attitudes towards these products and any resistance to scientific-based communication actions that can reassure consumers and counteract negative beliefs.
Published: 2024

7. Immunological characterization of a long-lasting response in a patient with metastatic triple-negative breast cancer treated with PD-1 and LAG-3 blockade

Author: Rivoltini, L, Camisaschi, C, Fucà, G, Paolini, B, Vergani, B, Beretta, V, Damian, S, Duca, M, Cresta, S, Magni, M, Leone, B, Castelli, C, de Braud, F, De Santis, F, Di Nicola, M, Rivoltini, Licia, Camisaschi, Chiara, Fucà, Giovanni, Paolini, Biagio, Vergani, Barbara, Beretta, Valeria, Damian, Silvia, Duca, Matteo, Cresta, Sara, Magni, Michele, Leone, Biagio Eugenio, Castelli, Chiara, de Braud, Filippo, De Santis, Francesca, Di Nicola, Massimo, Rivoltini, L, Camisaschi, C, Fucà, G, Paolini, B, Vergani, B, Beretta, V, Damian, S, Duca, M, Cresta, S, Magni, M, Leone, B, Castelli, C, de Braud, F, De Santis, F, Di Nicola, M, Rivoltini, Licia, Camisaschi, Chiara, Fucà, Giovanni, Paolini, Biagio, Vergani, Barbara, Beretta, Valeria, Damian, Silvia, Duca, Matteo, Cresta, Sara, Magni, Michele, Leone, Biagio Eugenio, Castelli, Chiara, de Braud, Filippo, De Santis, Francesca, and Di Nicola, Massimo
Abstract: In patients with advanced triple-negative breast cancer (TNBC), translational research efforts are needed to improve the clinical efficacy of immunotherapy with checkpoint inhibitors. Here, we report on the immunological characterization of an exceptional, long-lasting, tumor complete response in a patient with metastatic TNBC treated with dual PD-1 and LAG-3 blockade within the phase I/II study CLAG525X2101C (NCT02460224) The pre-treatment tumor biopsy revealed the presence of a CD3+ and CD8+ cell infiltrate, with few PD1+ cells, rare CD4+ cells, and an absence of both NK cells and LAG3 expression. Conversely, tumor cells exhibited positive staining for the three primary LAG-3 ligands (HLA-DR, FGL-1, and galectin-3), while being negative for PD-L1. In peripheral blood, baseline expression of LAG-3 and PD-1 was observed in circulating immune cells. Following treatment initiation, there was a rapid increase in proliferating granzyme-B+ NK and T cells, including CD4+ T cells, alongside a reduction in myeloid-derived suppressor cells. The role of LAG-3 expression on circulating NK cells, as well as the expression of LAG-3 ligands on tumor cells and the early modulation of circulating cytotoxic CD4+ T cells warrant further investigation as exploitable predictive biomarkers for dual PD-1 and LAG-3 blockade. Trial registration: NCT02460224. Registered 02/06/2015.
Published: 2024

8. Novel cellular systems unveil mucosal melanoma initiating cells and a role for PI3K/Akt/mTOR pathway in mucosal melanoma fitness

Author: Monti, M, Benerini Gatta, L, Bugatti, M, Pezzali, I, Picinoli, S, Manfredi, M, Lavazza, A, Vanella, V, De Giorgis, V, Zanatta, L, Missale, F, Lonardi, S, Zanetti, B, Bozzoni, G, Cadei, M, Abate, A, Vergani, B, Balzarini, P, Battocchio, S, Facco, C, Turri-Zanoni, M, Castelnuovo, P, Nicolai, P, Fonsatti, E, Leone, B, Marengo, E, Sigala, S, Ronca, R, Perego, M, Lombardi, D, Vermi, W, Monti, Matilde, Benerini Gatta, Luisa, Bugatti, Mattia, Pezzali, Irene, Picinoli, Sara, Manfredi, Marcello, Lavazza, Antonio, Vanella, Virginia Vita, De Giorgis, Veronica, Zanatta, Lucia, Missale, Francesco, Lonardi, Silvia, Zanetti, Benedetta, Bozzoni, Giovanni, Cadei, Moris, Abate, Andrea, Vergani, Barbara, Balzarini, Piera, Battocchio, Simonetta, Facco, Carla, Turri-Zanoni, Mario, Castelnuovo, Paolo, Nicolai, Piero, Fonsatti, Ester, Leone, Biagio Eugenio, Marengo, Emilio, Sigala, Sandra, Ronca, Roberto, Perego, Michela, Lombardi, Davide, Vermi, William, Monti, M, Benerini Gatta, L, Bugatti, M, Pezzali, I, Picinoli, S, Manfredi, M, Lavazza, A, Vanella, V, De Giorgis, V, Zanatta, L, Missale, F, Lonardi, S, Zanetti, B, Bozzoni, G, Cadei, M, Abate, A, Vergani, B, Balzarini, P, Battocchio, S, Facco, C, Turri-Zanoni, M, Castelnuovo, P, Nicolai, P, Fonsatti, E, Leone, B, Marengo, E, Sigala, S, Ronca, R, Perego, M, Lombardi, D, Vermi, W, Monti, Matilde, Benerini Gatta, Luisa, Bugatti, Mattia, Pezzali, Irene, Picinoli, Sara, Manfredi, Marcello, Lavazza, Antonio, Vanella, Virginia Vita, De Giorgis, Veronica, Zanatta, Lucia, Missale, Francesco, Lonardi, Silvia, Zanetti, Benedetta, Bozzoni, Giovanni, Cadei, Moris, Abate, Andrea, Vergani, Barbara, Balzarini, Piera, Battocchio, Simonetta, Facco, Carla, Turri-Zanoni, Mario, Castelnuovo, Paolo, Nicolai, Piero, Fonsatti, Ester, Leone, Biagio Eugenio, Marengo, Emilio, Sigala, Sandra, Ronca, Roberto, Perego, Michela, Lombardi, Davide, and Vermi, William
Abstract: Background: Mucosal Melanomas (MM) are highly aggressive neoplasms arising from mucosal melanocytes. Current treatments offer a limited survival benefit for patients with advanced MM; moreover, the lack of pre-clinical cellular systems has significantly limited the understanding of their immunobiology. Methods: Five novel cell lines were obtained from patient-derived biopsies of MM arising in the sino-nasal mucosa and designated as SN-MM1-5. The morphology, ultrastructure and melanocytic identity of SN-MM cell lines were validated by transmission electron microscopy and immunohistochemistry. Moreover, in vivo tumorigenicity of SN-MM1-5 was tested by subcutaneous injection in NOD/SCID mice. Molecular characterization of SN-MM cell lines was performed by a mass-spectrometry proteomic approach, and their sensitivity to PI3K chemical inhibitor LY294002 was validated by Akt activation, measured by pAkt(Ser473) and pAkt(Thr308) in immunoblots, and MTS assay. Results: This study reports the validation and functional characterization of five newly generated SN-MM cell lines. Compared to the normal counterpart, the proteomic profile of SN-MM is consistent with transformed melanocytes showing a heterogeneous degree of melanocytic differentiation and activation of cancer-related pathways. All SN-MM cell lines resulted tumorigenic in vivo and display recurrent structural variants according to aCGH analysis. Of relevance, the microscopic analysis of the corresponding xenotransplants allowed the identification of clusters of MITF-/CDH1-/CDH2 + /ZEB1 + /CD271 + cells, supporting the existence of melanoma-initiating cells also in MM, as confirmed in clinical samples. In vitro, SN-MM cell lines were sensitive to cisplatin, but not to temozolomide. Moreover, the proteomic analysis of SN-MM cell lines revealed that RICTOR, a subunit of mTORC2 complex, is the most significantly activated upstream regulator, suggesting a relevant role for the PI3K-Akt-mTOR pathway in these neoplasms. Co
Published: 2024

9. Estimating risk of endometrial malignancy and other intracavitary uterine pathology in women without abnormal uterine bleeding using IETA-1 multinomial regression model: validation study

Author: Heremans, R, Wynants, L, Valentin, L, Leone, F, Pascual, M, Fruscio, R, Testa, A, Buonomo, F, Guerriero, S, Epstein, E, Bourne, T, Timmerman, D, Van den Bosch, T, Leone, FPG, Pascual, MA, Testa, AC, Heremans, R, Wynants, L, Valentin, L, Leone, F, Pascual, M, Fruscio, R, Testa, A, Buonomo, F, Guerriero, S, Epstein, E, Bourne, T, Timmerman, D, Van den Bosch, T, Leone, FPG, Pascual, MA, and Testa, AC
Abstract: Objectives: To assess the ability of the International Endometrial Tumor Analysis (IETA)-1 polynomial regression model to estimate the risk of endometrial cancer (EC) and other intracavitary uterine pathology in women without abnormal uterine bleeding. Methods: This was a retrospective study, in which we validated the IETA-1 model on the IETA-3 study cohort (n = 1745). The IETA-3 study is a prospective observational multicenter study. It includes women without vaginal bleeding who underwent a standardized transvaginal ultrasound examination in one of seven ultrasound centers between January 2011 and December 2018. The ultrasonography was performed either as part of a routine gynecological examination, during follow-up of non-endometrial pathology, in the work-up before fertility treatment or before treatment for uterine prolapse or ovarian pathology. Ultrasonographic findings were described using IETA terminology and were compared with histology, or with results of clinical and ultrasound follow-up of at least 1 year if endometrial sampling was not performed. The IETA-1 model, which was created using data from patients with abnormal uterine bleeding, predicts four histological outcomes: (1) EC or endometrial intraepithelial neoplasia (EIN); (2) endometrial polyp or intracavitary myoma; (3) proliferative or secretory endometrium, endometritis, or endometrial hyperplasia without atypia; and (4) endometrial atrophy. The predictors in the model are age, body mass index and seven ultrasound variables (visibility of the endometrium, endometrial thickness, color score, cysts in the endometrium, non-uniform echogenicity of the endometrium, presence of a bright edge, presence of a single dominant vessel). We analyzed the discriminative ability of the model (area under the receiver-operating-characteristics curve (AUC); polytomous discrimination index (PDI)) and evaluated calibration of its risk estimates (observed/expected ratio). Results: The median age of the women in the
Published: 2024

10. Arginine methylation of SM-LIKE PROTEIN 4 antagonistically affects alternative splicing during Arabidopsis stress responses

Author: Alexander von Humboldt Foundation, Agencia Nacional de Promoción Científica y Tecnológica (Argentina), Max Planck Society, Consejo Nacional de Investigaciones Científicas y Técnicas (Argentina), Agrofoglio, Yamila Carla [0000-0002-0934-8754], Iglesias, María José [0000-0002-6007-5069], Perez-Santángelo, Soledad [00+00-0002-3497-9603], Leone, María José de [0000-0001-5915-0351], Köster, Tino [0000-0003-3984-9813], Catalá, Rafael [0000-0002-8668-7434], Salinas, Julio [0000-0003-2020-0950], Yanovsky, Marcelo J. [0000-0002-1890-0571], Staiger, Dorothee [0000-0002-1341-1381], Mateos, Julieta L. [0000-0002-1156-6662], Agrofoglio, Yamila Carla, Iglesias, María José, Perez-Santángelo, Soledad, Leone, María José de, Köster, Tino, Catalá, Rafael, Salinas, Julio, Yanovsky, Marcelo J., Staiger, Dorothee, Mateos, Julieta L., Alexander von Humboldt Foundation, Agencia Nacional de Promoción Científica y Tecnológica (Argentina), Max Planck Society, Consejo Nacional de Investigaciones Científicas y Técnicas (Argentina), Agrofoglio, Yamila Carla [0000-0002-0934-8754], Iglesias, María José [0000-0002-6007-5069], Perez-Santángelo, Soledad [00+00-0002-3497-9603], Leone, María José de [0000-0001-5915-0351], Köster, Tino [0000-0003-3984-9813], Catalá, Rafael [0000-0002-8668-7434], Salinas, Julio [0000-0003-2020-0950], Yanovsky, Marcelo J. [0000-0002-1890-0571], Staiger, Dorothee [0000-0002-1341-1381], Mateos, Julieta L. [0000-0002-1156-6662], Agrofoglio, Yamila Carla, Iglesias, María José, Perez-Santángelo, Soledad, Leone, María José de, Köster, Tino, Catalá, Rafael, Salinas, Julio, Yanovsky, Marcelo J., Staiger, Dorothee, and Mateos, Julieta L.
Abstract: Arabidopsis (Arabidopsis thaliana) PROTEIN ARGININE METHYLTRANSFERASE5 (PRMT5) post-translationally modifies RNA-binding proteins by arginine (R) methylation. However, the impact of this modification on the regulation of RNA processing is largely unknown. We used the spliceosome component, SM-LIKE PROTEIN 4 (LSM4), as a paradigm to study the role of R-methylation in RNA processing. We found that LSM4 regulates alternative splicing (AS) of a suite of its in vivo targets identified here. The lsm4 and prmt5 mutants show a considerable overlap of genes with altered AS raising the possibility that splicing of those genes could be regulated by PRMT5-dependent LSM4 methylation. Indeed, LSM4 methylation impacts AS, particularly of genes linked with stress response. Wild-type LSM4 and an unmethylable version complement the lsm4-1 mutant, suggesting that methylation is not critical for growth in normal environments. However, LSM4 methylation increases with abscisic acid and is necessary for plants to grow under abiotic stress. Conversely, bacterial infection reduces LSM4 methylation, and plants that express unmethylable-LSM4 are more resistant to Pseudomonas than those expressing wild-type LSM4. This tolerance correlates with decreased intron retention of immune-response genes upon infection. Taken together, this provides direct evidence that R-methylation adjusts LSM4 function on pre-mRNA splicing in an antagonistic manner in response to biotic and abiotic stress. © The Author(s) 2024.
Published: 2024

11. Clinical characteristics and outcomes of vaccinated patients hospitalised with SARS-CoV-2 breakthrough infection: Multi-IPV, a multicentre study in Northern Italy

Author: Lombardi, A, Villa, S, Colaneri, M, Scaglione, G, Bai, F, Varisco, B, Bono, V, Vena, A, Dentone, C, Russo, C, Tettamanti, M, Renisi, G, Viero, G, Azzarà, C, Mantero, M, Peyvandi, F, Bassetti, M, Marchetti, G, Muscatello, A, Nobili, A, Gori, A, Bandera, A, Bosari, S, Scudeller, L, Fusetti, G, Rusconi, L, Dell’Orto, S, Prati, D, Valenti, L, Giovannelli, S, Manunta, M, Lamorte, G, Ferarri, F, Gori., A, Mangioni, D, Alagna, L, Bozzi, G, Lombardi., A, Ungaro, R, Ancona, G, Mussa, M, Mariani, B, Bolis, M, Iannotti, N, Ludovisi, S, Comelli, A, Biscarini, S, Castelli, V, Palomba, E, Fava, M, Peri, C, Saltini, P, Itri, T, Ferroni, V, Pastore, V, Massafra, R, Liparoti, A, Muheberimana, T, Giommi, A, Bianco, R, Chitani, G, Bobbio, C, De Matteis, I, Bonomi, A, Gualtierotti, R, Ferrari, B, Rossio, R, Boasi, N, Pagliaro, E, Massimo, C, De Caro, M, Giachi, A, Montano, N, Vigone, B, Bellocchi, C, Carandina, A, Fiorelli, E, Melli, V, Tobaldini, E, Blasi, F, Aliberti, S, Spotti, M, Terranova, L, Misuraca, S, D’Adda, A, Della Fiore, S, Di Pasquale, M, Mantero., M, Contarini, M, Ori, M, Morlacchi, L, Rossetti, V, Gramegna, A, Pappalettera, M, Cavallini, M, Buscemi, A, Vicenzi, M, Rota, I, Costantino, G, Solbiati, M, Furlan, L, Mancarella, M, Colombo, G, Fanin, A, Passarella, M, Monzani, V, Canetta, C, Rovellini, A, Barbetta, L, Billi, F, Folli, C, Accordino, S, Maira, D, Hu, C, Motta, I, Scaramellini, N, Fracanzani, A, Lombardi, R, Cespiati, A, Cesari, M, Lucchi, T, Proietti, M, Calcaterra, L, Mandelli, C, Coppola, C, Cerizza, A, Pesenti, A, Grasselli, G, Galazzi, A, Nobili., A, Monti, I, Galbussera, A, Crisafulli, E, Girelli, D, Maroccia, A, Gabbiani, D, Busti, F, Vianello, A, Biondan, M, Sartori, F, Faverio, P, Pesci, A, Zucchetti, S, Bonfanti, P, Rossi, M, Beretta, I, Spolti, A, Harari, S, Elia, D, Cassandro, R, Caminati, A, Cipollone, F, Guagnano, M, D’Ardes, D, Rossi, I, Vezzani, F, Spanevello, A, Cherubino, F, Visca, D, Contoli, M, Papi, A, Morandi, L, Battistini, N, Moreo, G, Iannuzzi, P, Fumagalla, D, Leone, S, Lombardi, Andrea, Villa, Simone, Colaneri, Marta, Scaglione, Giovanni, Bai, Francesca, Varisco, Benedetta, Bono, Valeria, Vena, Antonio, Dentone, Chiara, Russo, Chiara, Tettamanti, Mauro, Renisi, Giulia, Viero, Giulia, Azzarà, Cecilia, Mantero, Marco, Peyvandi, Flora, Bassetti, Matteo, Marchetti, Giulia, Muscatello, Antonio, Nobili, Alessandro, Gori, Andrea, Bandera, Alessandra, Bosari, Silvano, Scudeller, Luigia, Fusetti, Giuliana, Rusconi, Laura, Dell’Orto, Silvia, Prati, Daniele, Valenti, Luca, Giovannelli, Silvia, Manunta, Maria, Lamorte, Giuseppe, Ferarri, Francesca, Gori. , Andrea, Mangioni, Davide, Alagna, Laura, Bozzi, Giorgio, Lombardi. , Andrea, Ungaro, Riccardo, Ancona, Giuseppe, Mussa, Marco, Mariani, Bianca Veronica, Bolis, Matteo, Iannotti, Nathalie, Ludovisi, Serena, Comelli, Agnese, Biscarini, Simona, Castelli, Valeria, Palomba, Emanuele, Fava, Marco, Peri, Carlo Alberto, Saltini, Paola, Itri, Teresa, Ferroni, Valentina, Pastore, Valeria, Massafra, Roberta, Liparoti, Arianna, Muheberimana, Toussaint, Giommi, Alessandro, Bianco, Rosaria, Chitani, Grazia Eliana, Bobbio, Chiara, De Matteis, Irene, Bonomi, Angelo Bianchi, Gualtierotti, Roberta, Ferrari, Barbara, Rossio, Raffaella, Boasi, Nadia, Pagliaro, Erica, Massimo, Costanza, De Caro, Michele, Giachi, Andrea, Montano, Nicola, Vigone, Barbara, Bellocchi, Chiara, Carandina, Angelica, Fiorelli, Elisa, Melli, Valerie, Tobaldini, Eleonora, Blasi, Francesco, Aliberti, Stefano, Spotti, Maura, Terranova, Leonardo, Misuraca, Sofia, D’Adda, Alice, Della Fiore, Silvia, Di Pasquale, Marta, Mantero. , Marco, Contarini, Martina, Ori, Margherita, Morlacchi, Letizia, Rossetti, Valeria, Gramegna, Andrea, Pappalettera, Maria, Cavallini, Mirta, Buscemi, Agata, Vicenzi, Marco, Rota, Irena, Costantino, Giorgio, Solbiati, Monica, Furlan, Ludovico, Mancarella, Marta, Colombo, Giulia, Colombo, Giorgio, Fanin, Alice, Passarella, Mariele, Monzani, Valter, Canetta, Ciro, Rovellini, Angelo, Barbetta, Laura, Billi, Filippo, Folli, Christian, Accordino, Silvia, Maira, Diletta, Hu, Cinzia Maria, Motta, Irene, Scaramellini, Natalia, Fracanzani, Anna Ludovica, Lombardi, Rosa, Cespiati, Annalisa, Cesari, Matteo, Lucchi, Tiziano, Proietti, Marco, Calcaterra, Laura, Mandelli, Clara, Coppola, Carlotta, Cerizza, Arturo, Pesenti, Antonio Maria, Grasselli, Giacomo, Galazzi, Alessandro, Nobili. , Alessandro, Monti, Igor, Galbussera, Alessia Antonella, Crisafulli, Ernesto, Girelli, Domenico, Maroccia, Alessio, Gabbiani, Daniele, Busti, Fabiana, Vianello, Alice, Biondan, Marta, Sartori, Filippo, Faverio, Paola, Pesci, Alberto, Zucchetti, Stefano, Bonfanti, Paolo, Rossi, Marianna, Beretta, Ilaria, Spolti, Anna, Harari, Sergio, Elia, Davide, Cassandro, Roberto, Caminati, Antonella, Cipollone, Francesco, Guagnano, Maria Teresa, D’Ardes, Damiano, Rossi, Ilaria, Vezzani, Francesca, Spanevello, Antonio, Cherubino, Francesca, Visca, Dina, Contoli, Marco, Papi, Alberto, Morandi, Luca, Battistini, Nicholas, Moreo, Guido Luigi, Iannuzzi, Pasqualina, Fumagalla, Daniele, Leone, Sara, Lombardi, A, Villa, S, Colaneri, M, Scaglione, G, Bai, F, Varisco, B, Bono, V, Vena, A, Dentone, C, Russo, C, Tettamanti, M, Renisi, G, Viero, G, Azzarà, C, Mantero, M, Peyvandi, F, Bassetti, M, Marchetti, G, Muscatello, A, Nobili, A, Gori, A, Bandera, A, Bosari, S, Scudeller, L, Fusetti, G, Rusconi, L, Dell’Orto, S, Prati, D, Valenti, L, Giovannelli, S, Manunta, M, Lamorte, G, Ferarri, F, Gori., A, Mangioni, D, Alagna, L, Bozzi, G, Lombardi., A, Ungaro, R, Ancona, G, Mussa, M, Mariani, B, Bolis, M, Iannotti, N, Ludovisi, S, Comelli, A, Biscarini, S, Castelli, V, Palomba, E, Fava, M, Peri, C, Saltini, P, Itri, T, Ferroni, V, Pastore, V, Massafra, R, Liparoti, A, Muheberimana, T, Giommi, A, Bianco, R, Chitani, G, Bobbio, C, De Matteis, I, Bonomi, A, Gualtierotti, R, Ferrari, B, Rossio, R, Boasi, N, Pagliaro, E, Massimo, C, De Caro, M, Giachi, A, Montano, N, Vigone, B, Bellocchi, C, Carandina, A, Fiorelli, E, Melli, V, Tobaldini, E, Blasi, F, Aliberti, S, Spotti, M, Terranova, L, Misuraca, S, D’Adda, A, Della Fiore, S, Di Pasquale, M, Mantero., M, Contarini, M, Ori, M, Morlacchi, L, Rossetti, V, Gramegna, A, Pappalettera, M, Cavallini, M, Buscemi, A, Vicenzi, M, Rota, I, Costantino, G, Solbiati, M, Furlan, L, Mancarella, M, Colombo, G, Fanin, A, Passarella, M, Monzani, V, Canetta, C, Rovellini, A, Barbetta, L, Billi, F, Folli, C, Accordino, S, Maira, D, Hu, C, Motta, I, Scaramellini, N, Fracanzani, A, Lombardi, R, Cespiati, A, Cesari, M, Lucchi, T, Proietti, M, Calcaterra, L, Mandelli, C, Coppola, C, Cerizza, A, Pesenti, A, Grasselli, G, Galazzi, A, Nobili., A, Monti, I, Galbussera, A, Crisafulli, E, Girelli, D, Maroccia, A, Gabbiani, D, Busti, F, Vianello, A, Biondan, M, Sartori, F, Faverio, P, Pesci, A, Zucchetti, S, Bonfanti, P, Rossi, M, Beretta, I, Spolti, A, Harari, S, Elia, D, Cassandro, R, Caminati, A, Cipollone, F, Guagnano, M, D’Ardes, D, Rossi, I, Vezzani, F, Spanevello, A, Cherubino, F, Visca, D, Contoli, M, Papi, A, Morandi, L, Battistini, N, Moreo, G, Iannuzzi, P, Fumagalla, D, Leone, S, Lombardi, Andrea, Villa, Simone, Colaneri, Marta, Scaglione, Giovanni, Bai, Francesca, Varisco, Benedetta, Bono, Valeria, Vena, Antonio, Dentone, Chiara, Russo, Chiara, Tettamanti, Mauro, Renisi, Giulia, Viero, Giulia, Azzarà, Cecilia, Mantero, Marco, Peyvandi, Flora, Bassetti, Matteo, Marchetti, Giulia, Muscatello, Antonio, Nobili, Alessandro, Gori, Andrea, Bandera, Alessandra, Bosari, Silvano, Scudeller, Luigia, Fusetti, Giuliana, Rusconi, Laura, Dell’Orto, Silvia, Prati, Daniele, Valenti, Luca, Giovannelli, Silvia, Manunta, Maria, Lamorte, Giuseppe, Ferarri, Francesca, Gori. , Andrea, Mangioni, Davide, Alagna, Laura, Bozzi, Giorgio, Lombardi. , Andrea, Ungaro, Riccardo, Ancona, Giuseppe, Mussa, Marco, Mariani, Bianca Veronica, Bolis, Matteo, Iannotti, Nathalie, Ludovisi, Serena, Comelli, Agnese, Biscarini, Simona, Castelli, Valeria, Palomba, Emanuele, Fava, Marco, Peri, Carlo Alberto, Saltini, Paola, Itri, Teresa, Ferroni, Valentina, Pastore, Valeria, Massafra, Roberta, Liparoti, Arianna, Muheberimana, Toussaint, Giommi, Alessandro, Bianco, Rosaria, Chitani, Grazia Eliana, Bobbio, Chiara, De Matteis, Irene, Bonomi, Angelo Bianchi, Gualtierotti, Roberta, Ferrari, Barbara, Rossio, Raffaella, Boasi, Nadia, Pagliaro, Erica, Massimo, Costanza, De Caro, Michele, Giachi, Andrea, Montano, Nicola, Vigone, Barbara, Bellocchi, Chiara, Carandina, Angelica, Fiorelli, Elisa, Melli, Valerie, Tobaldini, Eleonora, Blasi, Francesco, Aliberti, Stefano, Spotti, Maura, Terranova, Leonardo, Misuraca, Sofia, D’Adda, Alice, Della Fiore, Silvia, Di Pasquale, Marta, Mantero. , Marco, Contarini, Martina, Ori, Margherita, Morlacchi, Letizia, Rossetti, Valeria, Gramegna, Andrea, Pappalettera, Maria, Cavallini, Mirta, Buscemi, Agata, Vicenzi, Marco, Rota, Irena, Costantino, Giorgio, Solbiati, Monica, Furlan, Ludovico, Mancarella, Marta, Colombo, Giulia, Colombo, Giorgio, Fanin, Alice, Passarella, Mariele, Monzani, Valter, Canetta, Ciro, Rovellini, Angelo, Barbetta, Laura, Billi, Filippo, Folli, Christian, Accordino, Silvia, Maira, Diletta, Hu, Cinzia Maria, Motta, Irene, Scaramellini, Natalia, Fracanzani, Anna Ludovica, Lombardi, Rosa, Cespiati, Annalisa, Cesari, Matteo, Lucchi, Tiziano, Proietti, Marco, Calcaterra, Laura, Mandelli, Clara, Coppola, Carlotta, Cerizza, Arturo, Pesenti, Antonio Maria, Grasselli, Giacomo, Galazzi, Alessandro, Nobili. , Alessandro, Monti, Igor, Galbussera, Alessia Antonella, Crisafulli, Ernesto, Girelli, Domenico, Maroccia, Alessio, Gabbiani, Daniele, Busti, Fabiana, Vianello, Alice, Biondan, Marta, Sartori, Filippo, Faverio, Paola, Pesci, Alberto, Zucchetti, Stefano, Bonfanti, Paolo, Rossi, Marianna, Beretta, Ilaria, Spolti, Anna, Harari, Sergio, Elia, Davide, Cassandro, Roberto, Caminati, Antonella, Cipollone, Francesco, Guagnano, Maria Teresa, D’Ardes, Damiano, Rossi, Ilaria, Vezzani, Francesca, Spanevello, Antonio, Cherubino, Francesca, Visca, Dina, Contoli, Marco, Papi, Alberto, Morandi, Luca, Battistini, Nicholas, Moreo, Guido Luigi, Iannuzzi, Pasqualina, Fumagalla, Daniele, and Leone, Sara
Abstract: Background: Despite the well-known efficacy of anti-COVID-19 vaccines in preventing morbidity and mortality, several vaccinated individuals are diagnosed with SARS-CoV-2 breakthrough infection, which might require hospitalisation. This multicentre, observational, and retrospective study aimed to investigate the clinical characteristics and outcomes of vaccinated vs. non-vaccinated patients, both hospitalised with SARS-CoV-2 infection in 3 major hospitals in Northern Italy. Methods: Data collection was retrospective, and paper and electronic medical records of adult patients with a diagnosed SARS-CoV-2 infection were pseudo-anonymised and analysed. Vaccinated and non-vaccinated individuals were manually paired, using a predetermined matching criterion (similar age, gender, and date of hospitalisation). Demographic, clinical, treatment, and outcome data were compared between groups differing by vaccination status using Pearson's Chi-square and Mann-Whitney tests. Moreover, multiple logistic regression analyses were performed to assess the impact of vaccination status on ICU admission or intra-hospital mortality. Results: Data from 360 patients were collected. Vaccinated patients presented with a higher prevalence of relevant comorbidities, like kidney replacement therapy or haematological malignancy, despite a milder clinical presentation at the first evaluation. Non-vaccinated patients required intensive care more often than their vaccinated counterparts (8.8% vs. 1.7%, p = 0.002). Contrariwise, no difference in intra-hospital mortality was observed between the two groups (19% vs. 20%, p = 0.853). These results were confirmed by multivariable logistic regressions, which showed that vaccination was significantly associated with decreased risk of ICU admission (aOR=0.172, 95%CI: 0.039–0.542, p = 0.007), but not of intra-hospital mortality (aOR=0.996, 95%CI: 0.582–1.703, p = 0.987). Conclusions: This study provides real-world data on vaccinated patients hospitalised wit
Published: 2024

12. Proposal of a classification of cannulation damage in vascular access grafts based on clinical, ultrasound, and microscopic observations

Author: Franchin, M, Vergani, B, Huber, V, Leone, B, Villa, A, Muscato, P, Cervarolo, M, Piffaretti, G, Tozzi, M, Franchin M., Vergani B., Huber V., Leone B. E., Villa A., Muscato P., Cervarolo M. C., Piffaretti G., Tozzi M., Franchin, M, Vergani, B, Huber, V, Leone, B, Villa, A, Muscato, P, Cervarolo, M, Piffaretti, G, Tozzi, M, Franchin M., Vergani B., Huber V., Leone B. E., Villa A., Muscato P., Cervarolo M. C., Piffaretti G., and Tozzi M.
Abstract: Introduction: Arteriovenous grafts (AVGs) serve as an alternative to native arteriovenous fistulas (AVFs) in the context of hemodialysis patient life planning. AVGs are more susceptible to developing outflow stenosis (due to intimal hyperplasia), thrombosis, and infections. However, an often overlooked contributor to AVG failure is cannulation damage. The objective of this paper is to assess the impact of cannulations on AVGs. We aim to establish a classification of AVG damage by comparing clinical data and ultrasound images with microscopic morphological findings obtained from explanted grafts.Materials and methods: This study is conducted at a single center. We included all patients who underwent AVG creation between 2011 and 2019. Comprehensive data on clinical history, follow-up, and complications were collected and reviewed. Duplex ultrasound (DUS) characteristics were documented, and all grafts explanted during the analysis period underwent optical microscopy evaluation. Finally, clinical data, along with DUS and microscopic findings, were integrated to derive a damage classification.Results: During the study period, 247 patients underwent 334 early cannulation AVGs. The median follow-up duration was 714 days (IQR 392, 1195). One hundred eleven (33%) grafts were explanted. Clinical data and DUS findings were utilized to formulate a four-grade classification system indicating increasing damage.Conclusion: Cannulation damage alone does not solely account for AVG failure. It results from a biological host-mediated process that promotes the growth of intimal hyperplasia at the cannulation sites. This process is not clinically significant within the initial 2 years after AVG creation.
Published: 2024

13. Influence of Pathophysiological Patterns of Coronary Artery Disease on Immediate Percutaneous Coronary Intervention Outcomes

Author: Collet, Carlo, Munhoz, Daniel, Mizukami, Takuya, Sonck, Jeroen, Matsuo, Hitoshi, Shinke, Toshiro, Ando, Hirohiko, Ko, Brian, Biscaglia, Simone, Rivero, Fernando, Engstrøm, Thoma, Arslani, Ketina, Leone, Antonio Maria, van Nunen, Lokien X, Fearon, William F, Christiansen, Evald Høj, Fournier, Stephane, Desta, Liyew, Yong, Andy, Adjej, Julien, Escaned, Javier, Nakayama, Masafumi, Eftekhari, Ashkan, Zimmermann, Frederik M, Sakai, Koshiro, Storozhenko, Tatyana, da Costa, Bruno R, Campo, Gianluca, West, Nick E J, De Potter, Tom, Heggermont, Ward, Buytaert, Dimitri, Bartunek, Jozef, Berry, Colin, Collison, Damien, Johnson, Thoma, Amano, Tetsuya, Perera, Divaka, Jeremias, Allen, Ali, Ziad, Pijls, Nico H J, De Bruyne, Bernard, Johnson, Nils P, Leone, Antonio Maria (ORCID:0000-0002-1276-9883), Collet, Carlo, Munhoz, Daniel, Mizukami, Takuya, Sonck, Jeroen, Matsuo, Hitoshi, Shinke, Toshiro, Ando, Hirohiko, Ko, Brian, Biscaglia, Simone, Rivero, Fernando, Engstrøm, Thoma, Arslani, Ketina, Leone, Antonio Maria, van Nunen, Lokien X, Fearon, William F, Christiansen, Evald Høj, Fournier, Stephane, Desta, Liyew, Yong, Andy, Adjej, Julien, Escaned, Javier, Nakayama, Masafumi, Eftekhari, Ashkan, Zimmermann, Frederik M, Sakai, Koshiro, Storozhenko, Tatyana, da Costa, Bruno R, Campo, Gianluca, West, Nick E J, De Potter, Tom, Heggermont, Ward, Buytaert, Dimitri, Bartunek, Jozef, Berry, Colin, Collison, Damien, Johnson, Thoma, Amano, Tetsuya, Perera, Divaka, Jeremias, Allen, Ali, Ziad, Pijls, Nico H J, De Bruyne, Bernard, Johnson, Nils P, and Leone, Antonio Maria (ORCID:0000-0002-1276-9883)
Abstract: Background: Diffuse coronary artery disease (CAD) impacts the safety and efficacy of percutaneous coronary intervention (PCI). Pathophysiological CAD patterns can be quantified using fractional flow reserve (FFR) pullbacks incorporating the pullback pressure gradient (PPG) calculation. This study aimed to establish the capacity of PPG to predict optimal revascularisation and procedural outcomes. Methods: This prospective, investigator-initiated, single-arm, multicentre study enrolled patients with at least one epicardial lesion with an FFR ≤ 0.80 scheduled for PCI. Manual FFR pullbacks were employed to calculate PPG. The primary outcome of optimal revascularisation was defined as a post-PCI FFR ≥ 0.88. Results: 993 patients with 1044 vessels were included. The mean FFR was 0.68 ± 0.12, PPG 0.62 ± 0.17, and post-PCI FFR 0.87 ± 0.07. PPG was significantly correlated with the change in FFR after PCI (r=0.65, 95% CI 0.61-0.69, p<0.001) and demonstrated excellent predicted capacity for optimal revascularisation (AUC 0.82, 95% CI 0.79-0.84, p<0.001). Conversely, FFR alone did not predict revascularisation outcomes (AUC 0.54, 95% CI 0.50-0.57). PPG influenced treatment decisions in 14% of patients, redirecting them from PCI to alternative treatment modalities. Periprocedural myocardial infarction occurred more frequently in patients with low PPG (<0.62) compared to those with focal disease (OR 1.71, 95% CI: 1.00-2.97). Conclusions: Pathophysiological CAD patterns distinctly affect the safety and effectiveness of PCI. The PPG showed an excellent predictive capacity for optimal revascularisation and demonstrated added value compared to a FFR measurement.
Published: 2024

14. Optical Coherence Tomography Measures Predicting Fractional Flow Reserve: The OMEF Study

Author: Vergallo, Rocco, Lombardi, M., Kakuta, T., Pawlowski, T., Leone, Antonio Maria, Sardella, G., Agostoni, P., Hill, J. M., De Maria, Giovanni Luigi, Banning, A. P., Roleder, T., Belkacemi, A., Trani, Carlo, Burzotta, Francesco, Vergallo R., Leone A. M. (ORCID:0000-0002-1276-9883), De Maria G. L. (ORCID:0000-0003-3572-1855), Trani C. (ORCID:0000-0001-9777-013X), Burzotta F. (ORCID:0000-0002-6569-9401), Vergallo, Rocco, Lombardi, M., Kakuta, T., Pawlowski, T., Leone, Antonio Maria, Sardella, G., Agostoni, P., Hill, J. M., De Maria, Giovanni Luigi, Banning, A. P., Roleder, T., Belkacemi, A., Trani, Carlo, Burzotta, Francesco, Vergallo R., Leone A. M. (ORCID:0000-0002-1276-9883), De Maria G. L. (ORCID:0000-0003-3572-1855), Trani C. (ORCID:0000-0001-9777-013X), and Burzotta F. (ORCID:0000-0002-6569-9401)
Abstract: Background: Optical coherence tomography (OCT) allows to carefully characterize coronary plaque morphology and lumen dimensions. We sought to evaluate the value of OCT in predicting fractional flow reserve (FFR). Methods: We performed a multicenter, international, pooled analysis of individual patient-level data from published studies assessing FFR and OCT on the same vessel. Data from stable or unstable patients who underwent both FFR and OCT of the same coronary artery were collected through a dedicated database. Predefined OCT parameters were minimum lumen area (MLA), percentage area stenosis (%AS), and presence of thrombus or plaque rupture. Primary end point was FFR ≤0.80. Secondary outcome was the incidence of major adverse cardiac events in patients not undergoing revascularization based on negative FFR (>0.80). Results: A total of 502 coronary lesions in 489 patients were included. A significant correlation was observed between OCT-MLA and FFR values (R = 0.525; P < .001), and between OCT-%AS and FFR values (R = –0.482; P < .001). In Receiver operating characteristic analysis, MLA <2.0 mm2 showed a good discriminative power to predict an FFR ≤0.80 (AUC, 0.80), whereas %AS >73% showed a moderate discriminative power (AUC, 0.73). When considering proximal coronary segments, the best OCT cutoff values predicting an FFR ≤0.80 were MLA <3.1 mm2 (AUC, 0.82), and %AS >61% (AUC, 0.84). In patients with a negative FFR not revascularized, the combination of lower MLA and higher %AS had a trend toward worse outcome (which was statistically significant in the analysis restricted to proximal vessels). Conclusions: OCT lumen measures (MLA, %AS) may predict FFR, and different cutoffs are needed for proximal vessels.
Published: 2024

15. Efficacy of “Physiology-Guided PCI” Using Pressure Catheter in Comparison to Conventional Pressure Wires: A Multicenter Analysis

Author: Anastasia, G., Galante, D., Biscaglia, S., Vergallo, Rocco, Di Giusto, F., Migliaro, S., Petrolati, E., Vicere, A., Scancarello, D., Marrone, A., Verardi, F. M., Campaniello, Giorgia, Giuliana, Chiara, Pollio Benvenuto, Ciro, Viccaro, Vincenzo, Todisco, Simona, Burzotta, Francesco, Aurigemma, Cristina, Romagnoli, E., Trani, Carlo, Crea, Filippo, Porto, Italo, Campo, G., Leone, Antonio Maria, Vergallo R., Campaniello G., Giuliana C., Pollio Benvenuto C., Viccaro V., Todisco S., Burzotta F. (ORCID:0000-0002-6569-9401), Aurigemma C., Trani C. (ORCID:0000-0001-9777-013X), Crea F. (ORCID:0000-0001-9404-8846), Porto I. (ORCID:0000-0002-9854-5046), Leone A. M. (ORCID:0000-0002-1276-9883), Anastasia, G., Galante, D., Biscaglia, S., Vergallo, Rocco, Di Giusto, F., Migliaro, S., Petrolati, E., Vicere, A., Scancarello, D., Marrone, A., Verardi, F. M., Campaniello, Giorgia, Giuliana, Chiara, Pollio Benvenuto, Ciro, Viccaro, Vincenzo, Todisco, Simona, Burzotta, Francesco, Aurigemma, Cristina, Romagnoli, E., Trani, Carlo, Crea, Filippo, Porto, Italo, Campo, G., Leone, Antonio Maria, Vergallo R., Campaniello G., Giuliana C., Pollio Benvenuto C., Viccaro V., Todisco S., Burzotta F. (ORCID:0000-0002-6569-9401), Aurigemma C., Trani C. (ORCID:0000-0001-9777-013X), Crea F. (ORCID:0000-0001-9404-8846), Porto I. (ORCID:0000-0002-9854-5046), and Leone A. M. (ORCID:0000-0002-1276-9883)
Abstract: N/A
Published: 2024

16. Predicting the response to acetylcholine in ischemia or infarction with non-obstructive coronary arteries: The ABCD score

Author: Rinaldi, Riccardo, Colucci, Michele, Torre, Ilaria, Ausiello, Davide, Bonanni, Alice, Basile, Mattia, Salzillo, Carmine, Sanna, Tommaso, Liuzzo, Giovanna, Leone, Antonio Maria, Burzotta, Francesco, Trani, Carlo, Lanza, Gaetano Antonio, Niccoli, Giampaolo, Crea, Filippo, Montone, Rocco Antonio, Sanna, Tommaso (ORCID:0000-0002-5760-6885), Liuzzo, Giovanna (ORCID:0000-0002-5714-0907), Leone, Antonio M (ORCID:0000-0002-1276-9883), Burzotta, Francesco (ORCID:0000-0002-6569-9401), Trani, Carlo (ORCID:0000-0001-9777-013X), Lanza, Gaetano A (ORCID:0000-0003-2187-6653), Niccoli, Giampaolo (ORCID:0000-0002-3187-6262), Crea, Filippo (ORCID:0000-0001-9404-8846), Montone, Rocco A, Rinaldi, Riccardo, Colucci, Michele, Torre, Ilaria, Ausiello, Davide, Bonanni, Alice, Basile, Mattia, Salzillo, Carmine, Sanna, Tommaso, Liuzzo, Giovanna, Leone, Antonio Maria, Burzotta, Francesco, Trani, Carlo, Lanza, Gaetano Antonio, Niccoli, Giampaolo, Crea, Filippo, Montone, Rocco Antonio, Sanna, Tommaso (ORCID:0000-0002-5760-6885), Liuzzo, Giovanna (ORCID:0000-0002-5714-0907), Leone, Antonio M (ORCID:0000-0002-1276-9883), Burzotta, Francesco (ORCID:0000-0002-6569-9401), Trani, Carlo (ORCID:0000-0001-9777-013X), Lanza, Gaetano A (ORCID:0000-0003-2187-6653), Niccoli, Giampaolo (ORCID:0000-0002-3187-6262), Crea, Filippo (ORCID:0000-0001-9404-8846), and Montone, Rocco A
Abstract: Background and aims: Acetylcholine (ACh) provocation testing can detect vasomotor disorders in patients with ischemia and non-obstructed coronary arteries (INOCA) or myocardial infarction and non-obstructed coronary arteries (MINOCA). We aimed to derive and validate a simple risk score to predict a positive ACh test response. Methods: We prospectively enrolled consecutive INOCA and MINOCA patients undergoing ACh provocation testing. Patients were split in two cohorts (derivation and validation) according to time of enrolment. The score was derived in 386 patients (derivation cohort) and then validated in 165 patients (validation cohort). Results: 551 patients were enrolled, 371 (67.3%) INOCA and 180 (32.7%) MINOCA. ACh test was positive in 288 (52.3%) patients. MINOCA, myocardial bridge (MB), C-reactive protein (CRP) and dyslipidaemia were independent predictors of a positive ACh test in the derivation cohort. The ABCD (Acute presentation, Bridge, CRP, Dyslipidaemia) score was derived: 2 points were assigned to MINOCA, 3 to MB, 1 to elevated CRP and 1 to dyslipidaemia. The ABCD score accurately identified patients with a positive ACh test response with an AUC of 0.703 (CI 95% 0.652-0.754,p < 0.001) in the derivation cohort, and 0.705 (CI 95% 0.626-0.784, p < 0.001) in the validation cohort. In the whole population, an ABCD score ≥4 portended 94.3% risk of a positive ACh test and all patients with an ABCD score ≥6 presented a positive test. Conclusions: The ABCD score could avoid the need of ACh provocation testing in patients with a high score, reducing procedural risks, time, and costs, and allowing the implementation of a tailored treatment strategy. These results are hypothesis generating and further research involving larger cohorts and multicentre trials is needed to validate and refine the ABCD score.
Published: 2024

17. Fractional flow reserve or optical coherence tomography for angiographically intermediate coronary stenoses: 5-year outcomes in the FORZA trial

Author: Burzotta, Francesco, Zito, Andrea, Aurigemma, Cristina, Romagnoli, Enrico, Bianchini, Francesco, Bianchini, Emiliano, Paraggio, Lazzaro, Ierardi, Carolina, Crea, Filippo, Leone, Antonio Maria, Trani, Carlo, Burzotta, Francesco (ORCID:0000-0002-6569-9401), Crea, Filippo (ORCID:0000-0001-9404-8846), Leone, Antonio Maria (ORCID:0000-0002-1276-9883), Trani, Carlo (ORCID:0000-0001-9777-013X), Burzotta, Francesco, Zito, Andrea, Aurigemma, Cristina, Romagnoli, Enrico, Bianchini, Francesco, Bianchini, Emiliano, Paraggio, Lazzaro, Ierardi, Carolina, Crea, Filippo, Leone, Antonio Maria, Trani, Carlo, Burzotta, Francesco (ORCID:0000-0002-6569-9401), Crea, Filippo (ORCID:0000-0001-9404-8846), Leone, Antonio Maria (ORCID:0000-0002-1276-9883), and Trani, Carlo (ORCID:0000-0001-9777-013X)
Abstract: N/A
Published: 2024

18. Intravascular Ultrasound in the Detection of Bridging Stent Graft Instability During Fenestrated and Branched Endovascular Aneurysm Repair Procedures : A Multicentre Study on 274 Target Vessels

Author: Asciutto, Giuseppe, Ibrahim, Abdulhakim, Leone, Nicola, Gennai, Stefano, Piazza, Michele, Antonello, Michele, Wanhainen, Anders, Mani, Kevin, Lindström, David, Struk, Lisa, Oberhuber, Alexander, Asciutto, Giuseppe, Ibrahim, Abdulhakim, Leone, Nicola, Gennai, Stefano, Piazza, Michele, Antonello, Michele, Wanhainen, Anders, Mani, Kevin, Lindström, David, Struk, Lisa, and Oberhuber, Alexander
Abstract: OBJECTIVE: The use of intravascular ultrasound (IVUS) reduces contrast medium use and radiation exposure during conventional endovascular aneurysm repair (EVAR). The aim of this study was to evaluate the safety and efficacy of IVUS in detecting bridging stent graft (bSG) instability during fenestrated and branched EVAR (F/B-EVAR). METHODS: This was a prospective observational multicentre study. The following outcomes were evaluated: (1) technical success of the IVUS in each bSG, (2) IVUS findings compared with intra-operative angiography, (3) incidence of post-operative computed tomography angiography (CTA) findings not detected with IVUS, and (4) absence of IVUS related adverse events. Target visceral vessel (TVV) instability was defined as any branch or fenestration issues requiring an additional manoeuvre or re-intervention. Any IVUS assessment that detected stenosis, kinking, or any geometric TVV issue was considered to be branch instability. All procedures were performed in ad hoc hybrid rooms. RESULTS: Eighty patients (69% males; median age 72 years; interquartile range 59, 77 years) from four aortic centres treated with F/B-EVAR between January 2019 and September 2021 were included: 70 BEVAR (21 off the shelf; 49 custom made), eight FEVAR (custom made), and two F/B-EVAR (custom made), for a total of 300 potential TVVs. Two TVVs (0.7%) were left unstented and excluded from the analysis. The TVVs could not be accessed with the IVUS catheter in seven cases (2.3%). Furthermore, 17 (5.7%) TVVs could not be examined due to a malfunction of the IVUS catheter. The technical success of the IVUS assessment was 91.9% (274/298), with no IVUS related adverse events. Seven TVVs (2.5%) showed signs of bSG instability by means of IVUS, leading to immediate revisions. The first post-operative CTA at least 30 days after the index procedure was available in 268 of the 274 TVVs originally assessed by IVUS. In seven of the 268 TVVs (2.6%) a re-intervention became necessary due to
Published: 2024
Full Text: View/download PDF

19. Circulating biomarkers in familial cerebral cavernous malformation

Author: Lazzaroni, Francesca, Meessen, Jennifer M. T. A., Sun, Ying, Lanfranconi, Silvia, Scola, Elisa, D'Alessandris, Quintino Giorgio, Tassi, Laura, Carriero, Maria Rita, Castori, Marco, Marino, Silvia, Blanda, Adriana, Nicolis, Enrico B., Novelli, Deborah, Calabrese, Roberta, Agnelli, Nicolo M., Bottazzi, Barbara, Leone, Roberto, Mazzola, Selene, Besana, Silvia, Catozzi, Carlotta, Nezi, Luigi, Lampugnani, Maria G., Malinverno, Matteo, Grdseloff, Nastasja, Roedel, Claudia J., Jahromi, Behnam Rezai, Bolli, Niccolo, Passamonti, Francesco, Magnusson, Peetra, Abdelilah-Seyfried, Salim, Dejana, Elisabetta, Latini, Roberto, Lazzaroni, Francesca, Meessen, Jennifer M. T. A., Sun, Ying, Lanfranconi, Silvia, Scola, Elisa, D'Alessandris, Quintino Giorgio, Tassi, Laura, Carriero, Maria Rita, Castori, Marco, Marino, Silvia, Blanda, Adriana, Nicolis, Enrico B., Novelli, Deborah, Calabrese, Roberta, Agnelli, Nicolo M., Bottazzi, Barbara, Leone, Roberto, Mazzola, Selene, Besana, Silvia, Catozzi, Carlotta, Nezi, Luigi, Lampugnani, Maria G., Malinverno, Matteo, Grdseloff, Nastasja, Roedel, Claudia J., Jahromi, Behnam Rezai, Bolli, Niccolo, Passamonti, Francesco, Magnusson, Peetra, Abdelilah-Seyfried, Salim, Dejana, Elisabetta, and Latini, Roberto
Abstract: Background Cerebral Cavernous Malformation (CCM) is a rare cerebrovascular disease, characterized by the presence of multiple vascular malformations that may result in intracerebral hemorrhages (ICHs), seizure(s), or focal neurological deficits (FND). Familial CCM (fCCM) is due to loss of function mutations in one of the three independent genes KRIT1 (CCM1), Malcavernin (CCM2), or Programmed Cell death 10 (PDCD10/CCM3). The aim of this study was to identify plasma protein biomarkers of fCCM to assess the severity of the disease and predict its progression.Methods Here, we have investigated plasma samples derived from n = 71 symptomatic fCCM patients (40 female/31 male) and n =17 healthy donors (HD) (9 female/8 male) of the Phase 1/2 Treat_CCM trial, using multiplexed protein profiling approaches.Findings Biomarkers as sCD14 (p = 0.00409), LBP (p = 0.02911), CXCL4 (p = 0.038), ICAM-1 (p = 0.02013), ANG2 (p = 0.026), CCL5 (p = 0.00403), THBS1 (p = 0.0043), CRP (p = 0.0092), and HDL (p = 0.027), were significantly different in fCCM compared to HDs. Of note, sENG (p = 0.011), THBS1 (p = 0.011) and CXCL4 (p = 0.011), were correlated to CCM genotype. sROBO4 (p = 0.014), TM (p = 0.026) and CRP (p = 0.040) were able to predict incident adverse clinical events, such as ICH, FND or seizure. GDF-15, FLT3L, CXCL9, FGF-21 and CDCP1, were identified as predictors of the formation of new MRI-detectable lesions over 2-year follow-up. Furthermore, the functional relevance of ang2, thbs1, robo4 and cdcp1 markers was validated by zebrafish pre-clinical model of fCCM.Interpretation Overall, our study identifies a set of biochemical parameters to predict CCM progression, suggesting biological interpretations and potential therapeutic approaches to CCM disease.
Published: 2024
Full Text: View/download PDF

20. Intravascular ultrasound in the detection of bridging stent graft instability during fenestrated and branched endovascular aneurysm repair procedures : a multicentre study on 274 target vessels

Author: Asciutto, Giuseppe, Ibrahim, Abdulhakim, Leone, Nicola, Gennai, Stefano, Piazza, Michele, Antonello, Michele, Wanhainen, Anders, Mani, Kevin, Lindström, David, Struk, Lisa, Oberhuber, Alexander, Asciutto, Giuseppe, Ibrahim, Abdulhakim, Leone, Nicola, Gennai, Stefano, Piazza, Michele, Antonello, Michele, Wanhainen, Anders, Mani, Kevin, Lindström, David, Struk, Lisa, and Oberhuber, Alexander
Abstract: Objective: The use of intravascular ultrasound (IVUS) reduces contrast medium use and radiation exposure during conventional endovascular aneurysm repair (EVAR). The aim of this study was to evaluate the safety and efficacy of IVUS in detecting bridging stent graft (bSG) instability during fenestrated and branched EVAR (F/B-EVAR). Methods: This was a prospective observational multicentre study. The following outcomes were evaluated: (1) technical success of the IVUS in each bSG, (2) IVUS findings compared with intra-operative angiography, (3) incidence of post-operative computed tomography angiography (CTA) findings not detected with IVUS, and (4) absence of IVUS related adverse events. Target visceral vessel (TVV) instability was defined as any branch or fenestration issues requiring an additional manoeuvre or re-intervention. Any IVUS assessment that detected stenosis, kinking, or any geometric TVV issue was considered to be branch instability. All procedures were performed in ad hoc hybrid rooms. Results: Eighty patients (69% males; median age 72 years; interquartile range 59, 77 years) from four aortic centres treated with F/B-EVAR between January 2019 and September 2021 were included: 70 BEVAR (21 off the shelf; 49 custom made), eight FEVAR (custom made), and two F/B-EVAR (custom made), for a total of 300 potential TVVs. Two TVVs (0.7%) were left unstented and excluded from the analysis. The TVVs could not be accessed with the IVUS catheter in seven cases (2.3%). Furthermore, 17 (5.7%) TVVs could not be examined due to a malfunction of the IVUS catheter. The technical success of the IVUS assessment was 91.9% (274/298), with no IVUS related adverse events. Seven TVVs (2.5%) showed signs of bSG instability by means of IVUS, leading to immediate revisions. The first post-operative CTA at least 30 days after the index procedure was available in 268 of the 274 TVVs originally assessed by IVUS. In seven of the 268 TVVs (2.6%) a re-intervention became necessary due to
Published: 2024
Full Text: View/download PDF

21. Circulating biomarkers in familial cerebral cavernous malformation

Author: Lazzaroni, Francesca, Meessen, Jennifer M. T. A., Sun, Ying, Lanfranconi, Silvia, Scola, Elisa, D'Alessandris, Quintino Giorgio, Tassi, Laura, Carriero, Maria Rita, Castori, Marco, Marino, Silvia, Blanda, Adriana, Nicolis, Enrico B., Novelli, Deborah, Calabrese, Roberta, Agnelli, Nicolo M., Bottazzi, Barbara, Leone, Roberto, Mazzola, Selene, Besana, Silvia, Catozzi, Carlotta, Nezi, Luigi, Lampugnani, Maria G., Malinverno, Matteo, Grdseloff, Nastasja, Roedel, Claudia J., Jahromi, Behnam Rezai, Bolli, Niccolo, Passamonti, Francesco, Magnusson, Peetra, Abdelilah-Seyfried, Salim, Dejana, Elisabetta, Latini, Roberto, Lazzaroni, Francesca, Meessen, Jennifer M. T. A., Sun, Ying, Lanfranconi, Silvia, Scola, Elisa, D'Alessandris, Quintino Giorgio, Tassi, Laura, Carriero, Maria Rita, Castori, Marco, Marino, Silvia, Blanda, Adriana, Nicolis, Enrico B., Novelli, Deborah, Calabrese, Roberta, Agnelli, Nicolo M., Bottazzi, Barbara, Leone, Roberto, Mazzola, Selene, Besana, Silvia, Catozzi, Carlotta, Nezi, Luigi, Lampugnani, Maria G., Malinverno, Matteo, Grdseloff, Nastasja, Roedel, Claudia J., Jahromi, Behnam Rezai, Bolli, Niccolo, Passamonti, Francesco, Magnusson, Peetra, Abdelilah-Seyfried, Salim, Dejana, Elisabetta, and Latini, Roberto
Abstract: Background Cerebral Cavernous Malformation (CCM) is a rare cerebrovascular disease, characterized by the presence of multiple vascular malformations that may result in intracerebral hemorrhages (ICHs), seizure(s), or focal neurological deficits (FND). Familial CCM (fCCM) is due to loss of function mutations in one of the three independent genes KRIT1 (CCM1), Malcavernin (CCM2), or Programmed Cell death 10 (PDCD10/CCM3). The aim of this study was to identify plasma protein biomarkers of fCCM to assess the severity of the disease and predict its progression.Methods Here, we have investigated plasma samples derived from n = 71 symptomatic fCCM patients (40 female/31 male) and n =17 healthy donors (HD) (9 female/8 male) of the Phase 1/2 Treat_CCM trial, using multiplexed protein profiling approaches.Findings Biomarkers as sCD14 (p = 0.00409), LBP (p = 0.02911), CXCL4 (p = 0.038), ICAM-1 (p = 0.02013), ANG2 (p = 0.026), CCL5 (p = 0.00403), THBS1 (p = 0.0043), CRP (p = 0.0092), and HDL (p = 0.027), were significantly different in fCCM compared to HDs. Of note, sENG (p = 0.011), THBS1 (p = 0.011) and CXCL4 (p = 0.011), were correlated to CCM genotype. sROBO4 (p = 0.014), TM (p = 0.026) and CRP (p = 0.040) were able to predict incident adverse clinical events, such as ICH, FND or seizure. GDF-15, FLT3L, CXCL9, FGF-21 and CDCP1, were identified as predictors of the formation of new MRI-detectable lesions over 2-year follow-up. Furthermore, the functional relevance of ang2, thbs1, robo4 and cdcp1 markers was validated by zebrafish pre-clinical model of fCCM.Interpretation Overall, our study identifies a set of biochemical parameters to predict CCM progression, suggesting biological interpretations and potential therapeutic approaches to CCM disease.
Published: 2024
Full Text: View/download PDF

22. Circulating biomarkers in familial cerebral cavernous malformation

Author: Lazzaroni, Francesca, Meessen, Jennifer M. T. A., Sun, Ying, Lanfranconi, Silvia, Scola, Elisa, D'Alessandris, Quintino Giorgio, Tassi, Laura, Carriero, Maria Rita, Castori, Marco, Marino, Silvia, Blanda, Adriana, Nicolis, Enrico B., Novelli, Deborah, Calabrese, Roberta, Agnelli, Nicolo M., Bottazzi, Barbara, Leone, Roberto, Mazzola, Selene, Besana, Silvia, Catozzi, Carlotta, Nezi, Luigi, Lampugnani, Maria G., Malinverno, Matteo, Grdseloff, Nastasja, Roedel, Claudia J., Jahromi, Behnam Rezai, Bolli, Niccolo, Passamonti, Francesco, Magnusson, Peetra, Abdelilah-Seyfried, Salim, Dejana, Elisabetta, Latini, Roberto, Lazzaroni, Francesca, Meessen, Jennifer M. T. A., Sun, Ying, Lanfranconi, Silvia, Scola, Elisa, D'Alessandris, Quintino Giorgio, Tassi, Laura, Carriero, Maria Rita, Castori, Marco, Marino, Silvia, Blanda, Adriana, Nicolis, Enrico B., Novelli, Deborah, Calabrese, Roberta, Agnelli, Nicolo M., Bottazzi, Barbara, Leone, Roberto, Mazzola, Selene, Besana, Silvia, Catozzi, Carlotta, Nezi, Luigi, Lampugnani, Maria G., Malinverno, Matteo, Grdseloff, Nastasja, Roedel, Claudia J., Jahromi, Behnam Rezai, Bolli, Niccolo, Passamonti, Francesco, Magnusson, Peetra, Abdelilah-Seyfried, Salim, Dejana, Elisabetta, and Latini, Roberto
Abstract: Background Cerebral Cavernous Malformation (CCM) is a rare cerebrovascular disease, characterized by the presence of multiple vascular malformations that may result in intracerebral hemorrhages (ICHs), seizure(s), or focal neurological deficits (FND). Familial CCM (fCCM) is due to loss of function mutations in one of the three independent genes KRIT1 (CCM1), Malcavernin (CCM2), or Programmed Cell death 10 (PDCD10/CCM3). The aim of this study was to identify plasma protein biomarkers of fCCM to assess the severity of the disease and predict its progression.Methods Here, we have investigated plasma samples derived from n = 71 symptomatic fCCM patients (40 female/31 male) and n =17 healthy donors (HD) (9 female/8 male) of the Phase 1/2 Treat_CCM trial, using multiplexed protein profiling approaches.Findings Biomarkers as sCD14 (p = 0.00409), LBP (p = 0.02911), CXCL4 (p = 0.038), ICAM-1 (p = 0.02013), ANG2 (p = 0.026), CCL5 (p = 0.00403), THBS1 (p = 0.0043), CRP (p = 0.0092), and HDL (p = 0.027), were significantly different in fCCM compared to HDs. Of note, sENG (p = 0.011), THBS1 (p = 0.011) and CXCL4 (p = 0.011), were correlated to CCM genotype. sROBO4 (p = 0.014), TM (p = 0.026) and CRP (p = 0.040) were able to predict incident adverse clinical events, such as ICH, FND or seizure. GDF-15, FLT3L, CXCL9, FGF-21 and CDCP1, were identified as predictors of the formation of new MRI-detectable lesions over 2-year follow-up. Furthermore, the functional relevance of ang2, thbs1, robo4 and cdcp1 markers was validated by zebrafish pre-clinical model of fCCM.Interpretation Overall, our study identifies a set of biochemical parameters to predict CCM progression, suggesting biological interpretations and potential therapeutic approaches to CCM disease.
Published: 2024
Full Text: View/download PDF

23. Intravascular ultrasound in the detection of bridging stent graft instability during fenestrated and branched endovascular aneurysm repair procedures : a multicentre study on 274 target vessels

Author: Asciutto, Giuseppe, Ibrahim, Abdulhakim, Leone, Nicola, Gennai, Stefano, Piazza, Michele, Antonello, Michele, Wanhainen, Anders, Mani, Kevin, Lindström, David, Struk, Lisa, Oberhuber, Alexander, Asciutto, Giuseppe, Ibrahim, Abdulhakim, Leone, Nicola, Gennai, Stefano, Piazza, Michele, Antonello, Michele, Wanhainen, Anders, Mani, Kevin, Lindström, David, Struk, Lisa, and Oberhuber, Alexander
Abstract: Objective: The use of intravascular ultrasound (IVUS) reduces contrast medium use and radiation exposure during conventional endovascular aneurysm repair (EVAR). The aim of this study was to evaluate the safety and efficacy of IVUS in detecting bridging stent graft (bSG) instability during fenestrated and branched EVAR (F/B-EVAR). Methods: This was a prospective observational multicentre study. The following outcomes were evaluated: (1) technical success of the IVUS in each bSG, (2) IVUS findings compared with intra-operative angiography, (3) incidence of post-operative computed tomography angiography (CTA) findings not detected with IVUS, and (4) absence of IVUS related adverse events. Target visceral vessel (TVV) instability was defined as any branch or fenestration issues requiring an additional manoeuvre or re-intervention. Any IVUS assessment that detected stenosis, kinking, or any geometric TVV issue was considered to be branch instability. All procedures were performed in ad hoc hybrid rooms. Results: Eighty patients (69% males; median age 72 years; interquartile range 59, 77 years) from four aortic centres treated with F/B-EVAR between January 2019 and September 2021 were included: 70 BEVAR (21 off the shelf; 49 custom made), eight FEVAR (custom made), and two F/B-EVAR (custom made), for a total of 300 potential TVVs. Two TVVs (0.7%) were left unstented and excluded from the analysis. The TVVs could not be accessed with the IVUS catheter in seven cases (2.3%). Furthermore, 17 (5.7%) TVVs could not be examined due to a malfunction of the IVUS catheter. The technical success of the IVUS assessment was 91.9% (274/298), with no IVUS related adverse events. Seven TVVs (2.5%) showed signs of bSG instability by means of IVUS, leading to immediate revisions. The first post-operative CTA at least 30 days after the index procedure was available in 268 of the 274 TVVs originally assessed by IVUS. In seven of the 268 TVVs (2.6%) a re-intervention became necessary due to
Published: 2024
Full Text: View/download PDF

24. Rigid Vacua with Brane Supersymmetry Breaking

Author: Angelantonj, C., Condeescu, C., Dudas, E., Leone, G., Angelantonj, C., Condeescu, C., Dudas, E., and Leone, G.
Abstract: We construct new string vacua featuring Brane Supersymmetry Breaking, based on $T^4/\mathbb{Z}_N$ orientifolds with $\text{O}5_+$ planes and $\overline{\text{D}5}$ branes. Differently from the original construction, in these vacua the cancellation of twisted R-R charges of D-branes and orientifold planes is achieved in a non-trivial way, and results in rigid configurations with few open-string moduli, which highly restrict the possible deformations of the model. The breaking of supersymmetry and, consequently, the non-vanishing untwisted and twisted NS-NS tadpoles, generates a rich potential both for the dilaton and the blown-up moduli. We also uncover the stringy origin of the $J$ form entering the gauge kinetic functions in the low-energy effective action, and display its relation to the NS-NS tadpoles for the scalars in the tensor multiplets. As a result, the $J$ form can be consistently identified also when supersymmetry is broken, thus solving an embarrassing puzzle related to its very existence. We also discuss the unitarity constraints for one-dimensional defects in these vacua, where the Ka$\check{\text{c}}$-Moody algebra for D9 and $\overline{\text{D}5}$ can be realised both in the left-moving and right-moving sectors., Comment: 1+52 pages
Published: 2024

25. Circulating biomarkers in familial cerebral cavernous malformation

Author: Lazzaroni, Francesca, Meessen, Jennifer M. T. A., Sun, Ying, Lanfranconi, Silvia, Scola, Elisa, D'Alessandris, Quintino Giorgio, Tassi, Laura, Carriero, Maria Rita, Castori, Marco, Marino, Silvia, Blanda, Adriana, Nicolis, Enrico B., Novelli, Deborah, Calabrese, Roberta, Agnelli, Nicolo M., Bottazzi, Barbara, Leone, Roberto, Mazzola, Selene, Besana, Silvia, Catozzi, Carlotta, Nezi, Luigi, Lampugnani, Maria G., Malinverno, Matteo, Grdseloff, Nastasja, Roedel, Claudia J., Jahromi, Behnam Rezai, Bolli, Niccolo, Passamonti, Francesco, Magnusson, Peetra, Abdelilah-Seyfried, Salim, Dejana, Elisabetta, Latini, Roberto, Lazzaroni, Francesca, Meessen, Jennifer M. T. A., Sun, Ying, Lanfranconi, Silvia, Scola, Elisa, D'Alessandris, Quintino Giorgio, Tassi, Laura, Carriero, Maria Rita, Castori, Marco, Marino, Silvia, Blanda, Adriana, Nicolis, Enrico B., Novelli, Deborah, Calabrese, Roberta, Agnelli, Nicolo M., Bottazzi, Barbara, Leone, Roberto, Mazzola, Selene, Besana, Silvia, Catozzi, Carlotta, Nezi, Luigi, Lampugnani, Maria G., Malinverno, Matteo, Grdseloff, Nastasja, Roedel, Claudia J., Jahromi, Behnam Rezai, Bolli, Niccolo, Passamonti, Francesco, Magnusson, Peetra, Abdelilah-Seyfried, Salim, Dejana, Elisabetta, and Latini, Roberto
Abstract: Background Cerebral Cavernous Malformation (CCM) is a rare cerebrovascular disease, characterized by the presence of multiple vascular malformations that may result in intracerebral hemorrhages (ICHs), seizure(s), or focal neurological deficits (FND). Familial CCM (fCCM) is due to loss of function mutations in one of the three independent genes KRIT1 (CCM1), Malcavernin (CCM2), or Programmed Cell death 10 (PDCD10/CCM3). The aim of this study was to identify plasma protein biomarkers of fCCM to assess the severity of the disease and predict its progression.Methods Here, we have investigated plasma samples derived from n = 71 symptomatic fCCM patients (40 female/31 male) and n =17 healthy donors (HD) (9 female/8 male) of the Phase 1/2 Treat_CCM trial, using multiplexed protein profiling approaches.Findings Biomarkers as sCD14 (p = 0.00409), LBP (p = 0.02911), CXCL4 (p = 0.038), ICAM-1 (p = 0.02013), ANG2 (p = 0.026), CCL5 (p = 0.00403), THBS1 (p = 0.0043), CRP (p = 0.0092), and HDL (p = 0.027), were significantly different in fCCM compared to HDs. Of note, sENG (p = 0.011), THBS1 (p = 0.011) and CXCL4 (p = 0.011), were correlated to CCM genotype. sROBO4 (p = 0.014), TM (p = 0.026) and CRP (p = 0.040) were able to predict incident adverse clinical events, such as ICH, FND or seizure. GDF-15, FLT3L, CXCL9, FGF-21 and CDCP1, were identified as predictors of the formation of new MRI-detectable lesions over 2-year follow-up. Furthermore, the functional relevance of ang2, thbs1, robo4 and cdcp1 markers was validated by zebrafish pre-clinical model of fCCM.Interpretation Overall, our study identifies a set of biochemical parameters to predict CCM progression, suggesting biological interpretations and potential therapeutic approaches to CCM disease.
Published: 2024
Full Text: View/download PDF

26. Refracture following vertebral fragility fracture when bone fragility is not recognized: summarizing findings from comparator arms of randomized clinical trials

Author: Porcu, G, Biffi, A, Ronco, R, Adami, G, Alvaro, R, Bogini, R, Caputi, A, Frediani, B, Gatti, D, Gonnelli, S, Iolascon, G, Lenzi, A, Leone, S, Michieli, R, Migliaccio, S, Nicoletti, T, Paoletta, M, Pennini, A, Piccirilli, E, Rossini, M, Tarantino, U, Cianferotti, L, Brandi, M, Corrao, G, Caputi, A P, Brandi, M L, Porcu, G, Biffi, A, Ronco, R, Adami, G, Alvaro, R, Bogini, R, Caputi, A, Frediani, B, Gatti, D, Gonnelli, S, Iolascon, G, Lenzi, A, Leone, S, Michieli, R, Migliaccio, S, Nicoletti, T, Paoletta, M, Pennini, A, Piccirilli, E, Rossini, M, Tarantino, U, Cianferotti, L, Brandi, M, Corrao, G, Caputi, A P, and Brandi, M L
Abstract: Purpose: Since vertebral fragility fractures (VFFs) might increase the risk of subsequent fractures, we evaluated the incidence rate and the refracture risk of subsequent vertebral and non-vertebral fragility fractures (nVFFs) in untreated patients with a previous VFF. Methods: We systematically searched PubMed, Embase, and Cochrane Library up to February 2022 for randomized clinical trials (RCTs) that analyzed the occurrence of subsequent fractures in untreated patients with prior VFFs. Two authors independently extracted data and appraised the risk of bias in the selected studies. Primary outcomes were subsequent VFFs, while secondary outcomes were further nVFFs. The outcome of refracture within ≥ 2 years after the index fracture was measured as (i) rate, expressed per 100 person-years (PYs), and (ii) risk, expressed in percentage. Results: Forty RCTs met our inclusion criteria, ranging from medium to high quality. Among untreated patients with prior VFFs, the rate of subsequent VFFs and nVFFs was 12 [95% confidence interval (CI) 9–16] and 6 (95% CI 5–8%) per 100 PYs, respectively. The higher the number of previous VFFs, the higher the incidence. Moreover, the risk of VFFs and nVFFs increased within 2 (16.6% and 8%) and 4 years (35.1% and 17.4%) based on the index VFF. Conclusion: The highest risk of subsequent VFFs or nVFFs was already detected within 2 years following the initial VFF. Thus, prompt interventions should be designed to improve the detection and treatment of VFFs, aiming to reduce the risk of future FFs and properly implement secondary preventive measures.
Published: 2024

27. Microwave hydrodiffusion and gravity and pressurized-liquid extraction for obtaining bioactive compounds from Solanum viarum

Author: Confortin, Tássia Carla, Todero, Izelmar, Luft, Luciana, Schmaltz, Silvana, Ferreira, Daniele de Freitas, Barin, Juliano Smanioto, Santos, Maicon Sérgio Nascimento dos, Mazutti, Marcio Antonio, Zabot, Giovani Leone, Tres, Marcus Vinícius, Confortin, Tássia Carla, Todero, Izelmar, Luft, Luciana, Schmaltz, Silvana, Ferreira, Daniele de Freitas, Barin, Juliano Smanioto, Santos, Maicon Sérgio Nascimento dos, Mazutti, Marcio Antonio, Zabot, Giovani Leone, and Tres, Marcus Vinícius
Abstract: Brazilian biodiversity is considered a source of bioactive substances, and one of the species found is Solanum viarum Dunal, which is mainly composed of pyrrolizidine alkaloids. The purpose of this study was to evaluate two non-conventional extraction techniques — microwave hydrodiffusion and gravity (MHG) and pressurized-liquid extraction (PLE) — in obtaining bioactive compounds from S. viarum. Different parameters were assessed that directly influenced the yield and chemical composition of extracts. For PLE, the percentage of ethanol and temperature were evaluated on yield and composition. For MHG, temperature and pressure were evaluated on the same responses. PLE presented the highest extract yield (26.11 wt.%) and bioactive compounds concentration, while the highest extract yield of MHG was 1.68 wt.%. Both techniques indicated efficiency in extracting integerrimine, senecionine, and quinic acid. Knowing the compounds present in plants, using different extractive methods, enables the development of research that addresses their possible potential in the future., A biodiversidade brasileira é considerada fonte de substâncias bioativas, e uma das espécies encontradas é a Solanum viarum Dunal, que é composta, principalmente, por alcaloides pirrolizidínicos. O propósito deste estudo foi avaliar duas técnicas de extração não convencionais — micro-ondas de hidrodifusão e gravidade (MHG) e extração em líquido pressurizado (ELP) — na obtenção de compostos bioativos de S. viarum. Foram examinados diferentes parâmetros que influenciaram diretamente o rendimento e a composição química dos extratos. Para ELP, foram avaliadas a porcentagem de etanol e a temperatura sobre os rendimentos e composição. Para MHG, temperatura e pressão foram avaliadas nas mesmas respostas. O ELP apresentou o maior rendimento de extrato (26,11% em peso) e concentração de compostos bioativos, enquanto o maior rendimento de extrato de MHG foi de 1,68% em peso. Ambas as técnicas indicaram eficiência na extração de integerrimina, senecionina e ácido quínico. Conhecer os compostos presentes nas plantas utilizando diferentes métodos extrativos possibilita o desenvolvimento de pesquisas que abordem seu possível potencial no futuro.
Published: 2024

28. PEGylated SOCS3 Mimetics Encapsulated into PLGA-NPs as Selective Inhibitors of JAK/STAT Pathway in TNBC Cells

Author: La Manna,Sara, Cugudda,Alessia, Mercurio,Flavia, Leone,Marilisa, Fortuna,Sara, Di Natale,Concetta, Lagreca,Elena, Netti,Paolo Antonio, Panzetta,Valeria, Marasco,Daniela, La Manna,Sara, Cugudda,Alessia, Mercurio,Flavia, Leone,Marilisa, Fortuna,Sara, Di Natale,Concetta, Lagreca,Elena, Netti,Paolo Antonio, Panzetta,Valeria, and Marasco,Daniela
Abstract: Sara La Manna,1 Alessia Cugudda,1 Flavia Anna Mercurio,2 Marilisa Leone,2 Sara Fortuna,3 Concetta Di Natale,4 Elena Lagreca,4 Paolo Antonio Netti,4 Valeria Panzetta,4 Daniela Marasco1 1Department of Pharmacy, CIRPEB: Research Center on Bioactive Peptides- University of Naples Federico II, Naples, 80131, Italy; 2Institute of Biostructures and Bioimaging (CNR), Naples, 80131, Italy; 3Italian Institute of Technology (IIT), Genova, 16152, Italy; 4Department of Ingegneria Chimica del Materiali e della Produzione Industriale (DICMAPI), University of Naples Federico II, Naples, 80125, ItalyCorrespondence: Daniela Marasco, Email daniela.marasco@unina.itIntroduction: SOCS3 (suppressor of cytokine signaling 3) protein is a crucial regulator of cytokine-induced inflammation, and its administration has been shown to have therapeutic effects. Recently, we designed a chimeric proteomimetic of SOCS3, mimicking the interfacing regions of a ternary complex composed of SOCS3, JAK2 (Janus kinase 2) and gp130 (glycoprotein 130) proteins. The derived chimeric peptide, KIRCONG chim, demonstrated limited mimetic function owing to its poor water solubility.Methods: We report investigations concerning a PEGylated variant of KIRCONG mimetic, named KIRCONG chim, bearing a PEG (Polyethylene glycol) moiety as a linker of noncontiguous SOCS3 regions. Its ability to bind to the catalytic domain of JAK2 was evaluated through MST (MicroScale Thermophoresis), as well as its stability in biological serum assays. The structural features of the cyclic compounds were investigated by CD (circular dichroism), nuclear magnetic resonance (NMR), and molecular dynamic (MD) studies. To evaluate the cellular effects, we employed a PLGA-nanoparticle as a delivery system after characterization using DLS and SEM techniques.Results: KIRCONG chim PEG-revealed selective penetration into triple-negative breast cancer (TNBC) MDA-MB-231 cells with respect to the human breast epithelial cell line (MCF10A), acting as a po
Published: 2024

29. Tuning Peptide-Based Nanofibers for Achieving Selective Doxorubicin Delivery in Triple-Negative Breast Cancer

Author: Bellavita,Rosa, Piccolo,Marialuisa, Leone,Linda, Ferraro,Maria Grazia, Dardano,Principia, De Stefano,Luca, Nastri,Flavia, Irace,Carlo, Falanga,Annarita, Galdiero,Stefania, Bellavita,Rosa, Piccolo,Marialuisa, Leone,Linda, Ferraro,Maria Grazia, Dardano,Principia, De Stefano,Luca, Nastri,Flavia, Irace,Carlo, Falanga,Annarita, and Galdiero,Stefania
Abstract: Rosa Bellavita,1,&ast; Marialuisa Piccolo,1,&ast; Linda Leone,2 Maria Grazia Ferraro,1,3 Principia Dardano,4 Luca De Stefano,4 Flavia Nastri,2 Carlo Irace,1 Annarita Falanga,5 Stefania Galdiero1,&ast; 1Department of Pharmacy, School of Medicine, University of Naples âFederico IIâ, Napoli, Italy; 2Department of Chemical Sciences, University of Napoli âFederico IIâ, Naples, Italy; 3School of Infection and Immunity, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK; 4Institute of Applied Sciences and Intelligent Systems, Consiglio Nazionale delle Ricerche, Naples, Italy; 5Department of Agricultural Science, University of Naples âFederico IIâ, Portici, Italy&ast;These authors contributed equally to this workCorrespondence: Stefania Galdiero, Email stefania.galdiero@unina.itIntroduction: The design of delivery tools that efficiently transport drugs into cells remains a major challenge in drug development for most pathological conditions. Triple-negative breast cancer (TNBC) is a very aggressive subtype of breast cancer with poor prognosis and limited effective therapeutic options.Purpose: In TNBC treatment, chemotherapy remains the milestone, and doxorubicin (Dox) represents the first-line systemic treatment; however, its non-selective distribution causes a cascade of side effects. To address these problems, we developed a delivery platform based on the self-assembly of amphiphilic peptides carrying several moieties on their surfaces, aimed at targeting, enhancing penetration, and therapy.Methods: Through a single-step self-assembly process, we used amphiphilic peptides to obtain nanofibers decorated on their surfaces with the selected moieties. The surface of the nanofiber was decorated with a cell-penetrating peptide (gH625), an EGFR-targeting peptide (P22), and Dox bound to the cleavage sequence selectively recognized and cleaved by MMP-9 to obtain on-demand drug release. Detailed physicochemical and cellul
Published: 2024

30. The potential of preregistration in psychology: Assessing preregistration producibility and preregistration-study consistency

Author: van den Akker, Olmo, Bakker, Marjan, van Assen, Marcel, Pennington, Charlotte Rebecca, Verweij, Leone, Elsherif, Mahmoud, Claesen, Aline, Gaillard, Stefan, Yeung, Siu Kit, Frankenberger, Jan-Luca, Krautter, Kai, Cockcroft, Jamie, Kreuer, Katharina, Evans, Thomas Rhys, Heppel, Frédérique, Schoch, Sarah, Korbmacher, Max, Yamada, Yuki, Albayrak-Aydemir, Nihan, Alzahawi, Shilaan, Sarafoglou, Alexandra, Sitnikov, Maksim, Děchtěrenko, Filip, Wingen, Sophia, Grinschgl, Sandra, Hartmann, Helena, Stewart, Suzanne L. K., de Oliveira, Cátia, Ashcroft-Jones, Sarah, Baker, Bradley, Wicherts, Jelte, van den Akker, Olmo, Bakker, Marjan, van Assen, Marcel, Pennington, Charlotte Rebecca, Verweij, Leone, Elsherif, Mahmoud, Claesen, Aline, Gaillard, Stefan, Yeung, Siu Kit, Frankenberger, Jan-Luca, Krautter, Kai, Cockcroft, Jamie, Kreuer, Katharina, Evans, Thomas Rhys, Heppel, Frédérique, Schoch, Sarah, Korbmacher, Max, Yamada, Yuki, Albayrak-Aydemir, Nihan, Alzahawi, Shilaan, Sarafoglou, Alexandra, Sitnikov, Maksim, Děchtěrenko, Filip, Wingen, Sophia, Grinschgl, Sandra, Hartmann, Helena, Stewart, Suzanne L. K., de Oliveira, Cátia, Ashcroft-Jones, Sarah, Baker, Bradley, and Wicherts, Jelte
Abstract: Study preregistration has become increasingly popular in psychology, but its potential to restrict researcher degrees of freedom has not yet been empirically verified. We used an extensive protocol to assess the producibility (i.e., the degree to which a study can be properly conducted based on the available information) of preregistrations and the consistency between preregistrations and their corresponding papers for 300 psychology studies. We found that preregistrations often lack methodological details and that undisclosed deviations from preregistered plans are frequent. These results highlight that biases due to researcher degrees of freedom remain possible in many preregistered studies. More comprehensive registration templates typically yielded more producible preregistrations. We did not find that the producibility and consistency of preregistrations differed over time or between original and replication studies. Furthermore, we found that operationalizations of variables were generally preregistered more producible and consistently than other study parts. Inconsistencies between preregistrations and published studies were mainly encountered for data collection procedures, statistical models, and exclusion criteria. Our results indicate that, to unlock the full potential of preregistration, researchers in psychology should aim to write more producible preregistrations, adhere to these preregistrations more faithfully, and more transparently report any deviations from their preregistrations. This could be facilitated by training and education to improve preregistration skills, as well as the development of more comprehensive templates.
Published: 2024

31. Time of sample collection is critical for the replicability of microbiome analyses

Author: Allaband, Celeste, Allaband, Celeste, Lingaraju, Amulya, Flores Ramos, Stephany, Kumar, Tanya, Javaheri, Haniyeh, Tiu, Maria D, Dantas Machado, Ana Carolina, Richter, R Alexander, Elijah, Emmanuel, Haddad, Gabriel G, Leone, Vanessa A, Dorrestein, Pieter C, Knight, Rob, Zarrinpar, Amir, Allaband, Celeste, Allaband, Celeste, Lingaraju, Amulya, Flores Ramos, Stephany, Kumar, Tanya, Javaheri, Haniyeh, Tiu, Maria D, Dantas Machado, Ana Carolina, Richter, R Alexander, Elijah, Emmanuel, Haddad, Gabriel G, Leone, Vanessa A, Dorrestein, Pieter C, Knight, Rob, and Zarrinpar, Amir
Abstract: As the microbiome field moves from descriptive and associative research to mechanistic and interventional studies, being able to account for all confounding variables in the experimental design, which includes the maternal effect1, cage effect2, facility differences3, as well as laboratory and sample handling protocols4, is critical for interpretability of results. Despite significant procedural and bioinformatic improvements, unexplained variability and lack of replicability still occur. One underexplored factor is that the microbiome is dynamic and exhibits diurnal oscillations that can change microbiome composition5-7. In this retrospective analysis of 16S amplicon sequencing studies in male mice, we show that sample collection time affects the conclusions drawn from microbiome studies and its effect size is larger than those of a daily experimental intervention or dietary changes. The timing of divergence of the microbiome composition between experimental and control groups is unique to each experiment. Sample collection times as short as only 4 hours apart can lead to vastly different conclusions. Lack of consistency in the time of sample collection may explain poor cross-study replicability in microbiome research. The impact of diurnal rhythms on the outcomes and study design of other fields is unknown but likely significant.
Published: 2024

32. Unresectable cardiac metastasis from melanoma responds well to combination immunotherapy - A case report

Author: Oh, Ek Leone, Dias, Peter, Al-Ogaili, Zeyad, Otto, Jacobus, Warburton, Lydia, Oh, Ek Leone, Dias, Peter, Al-Ogaili, Zeyad, Otto, Jacobus, and Warburton, Lydia
Abstract: Background: Melanoma can metastasize to distal organs including the heart although presentation with a symptomatic cardiac metastasis is rare. The optimal management remains uncertain particularly in the era of immunotherapy. Case summary: We report a case presenting with a large unresectable cardiac metastasis from melanoma that responded well to treatment with immunotherapy. Conclusion: Melanoma can metastasize to the heart and is often challenging to diagnose. Combination immunotherapy can be an effective treatment option even in the setting of a symptomatic and unresectable cardiac metastasis.
Published: 2024

33. Streamlining Requirements Engineering in Healthcare: An End-to-End Goal- and Process-Oriented Method

Author: de Winter, A.J. (Leone) and de Winter, A.J. (Leone)
Published: 2024

34. Terrestrial very-long-baseline atom interferometry : Workshop summary

Author: Abend, Sven, Allard, Baptiste, Alonso, Iván, Antoniadis, John, Araújo, Henrique, Arduini, Gianluigi, Arnold, Aidan S., Asano, Tobias, Augst, Nadja, Badurina, Leonardo, Balaz, Antun, Banks, Hannah, Barone, Michele, Barsanti, Michele, Bassi, Angelo, Battelier, Baptiste, Baynham, Charles F. A., Beaufils, Quentin, Belic, Aleksandar, Beniwal, Ankit, Bernabeu, Jose, Bertinelli, Francesco, Bertoldi, Andrea, Biswas, Ikbal Ahamed, Blas, Diego, Boegel, Patrick, Bogojevic, Aleksandar, Böhm, Jonas, Böhringer, Samuel, Bongs, Kai, Bouyer, Philippe, Brand, Christian, Brimis, Apostolos, Buchmueller, Oliver, Cacciapuoti, Luigi, Calatroni, Sergio, Canuel, Benjamin, Caprini, Chiara, Caramete, Ana, Caramete, Laurentiu, Carlesso, Matteo, Carlton, John, Casariego, Mateo, Charmandaris, Vassilis, Chen, Yu-Ao, Chiofalo, Maria Luisa, Cimbri, Alessia, Coleman, Jonathon, Constantin, Florin Lucian, Contaldi, Carlo R., Cui, Yanou, Ros, Elisa Da, Davies, Gavin, del Pino Rosendo, Esther, Deppner, Christian, Derevianko, Andrei, de Rham, Claudia, De Roeck, Albert, Derr, Daniel, Di Pumpo, Fabio, Djordjevic, Goran S., Döbrich, Babette, Domokos, Peter, Dornan, Peter, Doser, Michael, Drougakis, Giannis, Dunningham, Jacob, Duspayev, Alisher, Easo, Sajan, Eby, Joshua, Efremov, Maxim, Ekelöf, Tord, Elertas, Gedminas, Ellis, John, Evans, David, Fadeev, Pavel, Fani, Mattia, Fassi, Farida, Fattori, Marco, Fayet, Pierre, Felea, Daniel, Feng, Jie, Friedrich, Alexander, Fuchs, Elina, Gaaloul, Naceur, Gao, Dongfeng, Gardner, Susan, Garraway, Barry, Gauguet, Alexandre, Gerlach, Sandra, Gersemann, Matthias, Gibson, Valerie, Giese, Enno, Giudice, Gian F., Glasbrenner, Eric P., Gündogan, Mustafa, Haehnelt, Martin, Hakulinen, Timo, Hammerer, Klemens, Hanimeli, Ekim T., Harte, Tiffany, Hawkins, Leonie, Hees, Aurelien, Heise, Jaret, Henderson, Victoria A., Herrmann, Sven, Hird, Thomas M., Hogan, Jason M., Holst, Bodil, Holynski, Michael, Hussain, Kamran, Janson, Gregor, Jeglic, Peter, Jelezko, Fedor, Kagan, Michael, Kalliokoski, Matti, Kasevich, Mark, Kehagias, Alex, Kilian, Eva, Koley, Soumen, Konrad, Bernd, Kopp, Joachim, Kornakov, Georgy, Kovachy, Tim, Krutzik, Markus, Kumar, Mukesh, Kumar, Pradeep, Lämmerzahl, Claus, Landsberg, Greg, Langlois, Mehdi, Lanigan, Bryony, Lellouch, Samuel, Leone, Bruno, Poncin-Lafitte, Christophe Le, Lewicki, Marek, Leykauf, Bastian, Lezeik, Ali, Lombriser, Lucas, Luis Lopez-Gonzalez, J., Lopez Asamar, Elias, López Monjaraz, Cristian, Luciano, Giuseppe Gaetano, Mahmoud, M. A., Maleknejad, Azadeh, Marteau, Jacques, Massonnet, Didier, Mazumdar, Anupam, McCabe, Christopher, Meister, Matthias, Menu, Jonathan, Messineo, Giuseppe, Micalizio, Salvatore, Millington, Peter, Milosevic, Milan, Mitchell, Jeremiah, Montero, Mario, Morley, Gavin W., Müller, Jürgen, Müstecaploglu, Özgür E., Ni, Wei-Tou, Noller, Johannes, Odzak, Senad, Oi, Daniel K. L., Omar, Yasser, Pahl, Julia, Paling, Sean, Pandey, Saurabh, Pappas, George, Pareek, Vinay, Pasatembou, Elizabeth, Pelucchi, Emanuele, Pereira dos Santos, Franck, Piest, Baptist, Pikovski, Igor, Pilaftsis, Apostolos, Plunkett, Robert, Poggiani, Rosa, Prevedelli, Marco, Puputti, Julia, Veettil, Vishnupriya Puthiya, Quenby, John, Rafelski, Johann, Rajendran, Surjeet, Rasel, Ernst M., Sfar, Haifa Rejeb, Reynaud, Serge, Richaud, Andrea, Rodzinka, Tangui, Roura, Albert, Rudolph, Jan, Sabulsky, Dylan O., Safronova, Marianna S., Santamaria, Luigi, Schilling, Manuel, Schkolnik, Vladimir, Schleich, Wolfgang P., Schlippert, Dennis, Schneider, Ulrich, Schreck, Florian, Schubert, Christian, Schwersenz, Nico, Semakin, Aleksei, Sergijenko, Olga, Shao, Lijing, Shipsey, Ian, Singh, Rajeev, Smerzi, Augusto, Sopuerta, Carlos F., Spallicci, Alessandro D. A. M., Stefanescu, Petruta, Stergioulas, Nikolaos, Ströhle, Jannik, Struckmann, Christian, Tentindo, Silvia, Throssell, Henry, Tino, Guglielmo M., Tinsley, Jonathan N., Tintareanu Mircea, Ovidiu, Tkalcec, Kimberly, Tolley, Andrew J., Tornatore, Vincenza, Torres-Orjuela, Alejandro, Treutlein, Philipp, Trombettoni, Andrea, Tsai, Yu-Dai, Ufrecht, Christian, Ulmer, Stefan, Valuch, Daniel, Vaskonen, Ville, Vázquez-Aceves, Verónica, Vitanov, Nikolay V., Vogt, Christian, von Klitzing, Wolf, Vukics, András, Walser, Reinhold, Wang, Jin, Warburton, Niels, Webber-Date, Alexander, Wenzlawski, André, Werner, Michael, Williams, Jason, Windpassinger, Patrick, Wolf, Peter, Woerner, Lisa, Xuereb, André, Yahia, Mohamed E., Zambrini Cruzeiro, Emmanuel, Zarei, Moslem, Zhan, Mingsheng, Zhou, Lin, Zupan, Jure, Zupanic, Erik, Abend, Sven, Allard, Baptiste, Alonso, Iván, Antoniadis, John, Araújo, Henrique, Arduini, Gianluigi, Arnold, Aidan S., Asano, Tobias, Augst, Nadja, Badurina, Leonardo, Balaz, Antun, Banks, Hannah, Barone, Michele, Barsanti, Michele, Bassi, Angelo, Battelier, Baptiste, Baynham, Charles F. A., Beaufils, Quentin, Belic, Aleksandar, Beniwal, Ankit, Bernabeu, Jose, Bertinelli, Francesco, Bertoldi, Andrea, Biswas, Ikbal Ahamed, Blas, Diego, Boegel, Patrick, Bogojevic, Aleksandar, Böhm, Jonas, Böhringer, Samuel, Bongs, Kai, Bouyer, Philippe, Brand, Christian, Brimis, Apostolos, Buchmueller, Oliver, Cacciapuoti, Luigi, Calatroni, Sergio, Canuel, Benjamin, Caprini, Chiara, Caramete, Ana, Caramete, Laurentiu, Carlesso, Matteo, Carlton, John, Casariego, Mateo, Charmandaris, Vassilis, Chen, Yu-Ao, Chiofalo, Maria Luisa, Cimbri, Alessia, Coleman, Jonathon, Constantin, Florin Lucian, Contaldi, Carlo R., Cui, Yanou, Ros, Elisa Da, Davies, Gavin, del Pino Rosendo, Esther, Deppner, Christian, Derevianko, Andrei, de Rham, Claudia, De Roeck, Albert, Derr, Daniel, Di Pumpo, Fabio, Djordjevic, Goran S., Döbrich, Babette, Domokos, Peter, Dornan, Peter, Doser, Michael, Drougakis, Giannis, Dunningham, Jacob, Duspayev, Alisher, Easo, Sajan, Eby, Joshua, Efremov, Maxim, Ekelöf, Tord, Elertas, Gedminas, Ellis, John, Evans, David, Fadeev, Pavel, Fani, Mattia, Fassi, Farida, Fattori, Marco, Fayet, Pierre, Felea, Daniel, Feng, Jie, Friedrich, Alexander, Fuchs, Elina, Gaaloul, Naceur, Gao, Dongfeng, Gardner, Susan, Garraway, Barry, Gauguet, Alexandre, Gerlach, Sandra, Gersemann, Matthias, Gibson, Valerie, Giese, Enno, Giudice, Gian F., Glasbrenner, Eric P., Gündogan, Mustafa, Haehnelt, Martin, Hakulinen, Timo, Hammerer, Klemens, Hanimeli, Ekim T., Harte, Tiffany, Hawkins, Leonie, Hees, Aurelien, Heise, Jaret, Henderson, Victoria A., Herrmann, Sven, Hird, Thomas M., Hogan, Jason M., Holst, Bodil, Holynski, Michael, Hussain, Kamran, Janson, Gregor, Jeglic, Peter, Jelezko, Fedor, Kagan, Michael, Kalliokoski, Matti, Kasevich, Mark, Kehagias, Alex, Kilian, Eva, Koley, Soumen, Konrad, Bernd, Kopp, Joachim, Kornakov, Georgy, Kovachy, Tim, Krutzik, Markus, Kumar, Mukesh, Kumar, Pradeep, Lämmerzahl, Claus, Landsberg, Greg, Langlois, Mehdi, Lanigan, Bryony, Lellouch, Samuel, Leone, Bruno, Poncin-Lafitte, Christophe Le, Lewicki, Marek, Leykauf, Bastian, Lezeik, Ali, Lombriser, Lucas, Luis Lopez-Gonzalez, J., Lopez Asamar, Elias, López Monjaraz, Cristian, Luciano, Giuseppe Gaetano, Mahmoud, M. A., Maleknejad, Azadeh, Marteau, Jacques, Massonnet, Didier, Mazumdar, Anupam, McCabe, Christopher, Meister, Matthias, Menu, Jonathan, Messineo, Giuseppe, Micalizio, Salvatore, Millington, Peter, Milosevic, Milan, Mitchell, Jeremiah, Montero, Mario, Morley, Gavin W., Müller, Jürgen, Müstecaploglu, Özgür E., Ni, Wei-Tou, Noller, Johannes, Odzak, Senad, Oi, Daniel K. L., Omar, Yasser, Pahl, Julia, Paling, Sean, Pandey, Saurabh, Pappas, George, Pareek, Vinay, Pasatembou, Elizabeth, Pelucchi, Emanuele, Pereira dos Santos, Franck, Piest, Baptist, Pikovski, Igor, Pilaftsis, Apostolos, Plunkett, Robert, Poggiani, Rosa, Prevedelli, Marco, Puputti, Julia, Veettil, Vishnupriya Puthiya, Quenby, John, Rafelski, Johann, Rajendran, Surjeet, Rasel, Ernst M., Sfar, Haifa Rejeb, Reynaud, Serge, Richaud, Andrea, Rodzinka, Tangui, Roura, Albert, Rudolph, Jan, Sabulsky, Dylan O., Safronova, Marianna S., Santamaria, Luigi, Schilling, Manuel, Schkolnik, Vladimir, Schleich, Wolfgang P., Schlippert, Dennis, Schneider, Ulrich, Schreck, Florian, Schubert, Christian, Schwersenz, Nico, Semakin, Aleksei, Sergijenko, Olga, Shao, Lijing, Shipsey, Ian, Singh, Rajeev, Smerzi, Augusto, Sopuerta, Carlos F., Spallicci, Alessandro D. A. M., Stefanescu, Petruta, Stergioulas, Nikolaos, Ströhle, Jannik, Struckmann, Christian, Tentindo, Silvia, Throssell, Henry, Tino, Guglielmo M., Tinsley, Jonathan N., Tintareanu Mircea, Ovidiu, Tkalcec, Kimberly, Tolley, Andrew J., Tornatore, Vincenza, Torres-Orjuela, Alejandro, Treutlein, Philipp, Trombettoni, Andrea, Tsai, Yu-Dai, Ufrecht, Christian, Ulmer, Stefan, Valuch, Daniel, Vaskonen, Ville, Vázquez-Aceves, Verónica, Vitanov, Nikolay V., Vogt, Christian, von Klitzing, Wolf, Vukics, András, Walser, Reinhold, Wang, Jin, Warburton, Niels, Webber-Date, Alexander, Wenzlawski, André, Werner, Michael, Williams, Jason, Windpassinger, Patrick, Wolf, Peter, Woerner, Lisa, Xuereb, André, Yahia, Mohamed E., Zambrini Cruzeiro, Emmanuel, Zarei, Moslem, Zhan, Mingsheng, Zhou, Lin, Zupan, Jure, and Zupanic, Erik
Abstract: This document presents a summary of the 2023 Terrestrial Very-Long-Baseline Atom Interferometry Workshop hosted by CERN. The workshop brought together experts from around the world to discuss the exciting developments in large-scale atom interferometer (AI) prototypes and their potential for detecting ultralight dark matter and gravitational waves. The primary objective of the workshop was to lay the groundwork for an international TVLBAI proto-collaboration. This collaboration aims to unite researchers from different institutions to strategize and secure funding for terrestrial large-scale AI projects. The ultimate goal is to create a roadmap detailing the design and technology choices for one or more kilometer--scale detectors, which will be operational in the mid-2030s. The key sections of this report present the physics case and technical challenges, together with a comprehensive overview of the discussions at the workshop together with the main conclusions.
Published: 2024
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35. Terrestrial very-long-baseline atom interferometry: Workshop summary

Author: Abend, Sven, Allard, Baptiste, Alonso, Iván, Antoniadis, John, Araújo, Henrique, Arduini, Gianluigi, Arnold, Aidan S., Asano, Tobias, Augst, Nadja, Badurina, Leonardo, Balaž, Antun, Banks, Hannah, Barone, Michele, Barsanti, Michele, Bassi, Angelo, Battelier, Baptiste, Baynham, Charles F. A., Beaufils, Quentin, Belić, Aleksandar, Beniwal, Ankit, Bernabeu, Jose, Bertinelli, Francesco, Bertoldi, Andrea, Biswas, Ikbal Ahamed, Blas, Diego, Boegel, Patrick, Bogojević, Aleksandar, Böhm, Jonas, Böhringer, Samuel, Bongs, Kai, Bouyer, Philippe, Brand, Christian, Brimis, Apostolos, Buchmueller, Oliver, Cacciapuoti, Luigi, Calatroni, Sergio, Canuel, Benjamin, Caprini, Chiara, Caramete, Ana, Caramete, Laurentiu, Carlesso, Matteo, Carlton, John, Casariego, Mateo, Charmandaris, Vassilis, Chen, Yu-Ao, Chiofalo, Maria Luisa, Cimbri, Alessia, Coleman, Jonathon, Constantin, Florin Lucian, Contaldi, Carlo R., Cui, Yanou, Ros, Elisa Da, Davies, Gavin, Rosendo, Esther del Pino, Deppner, Christian, Derevianko, Andrei, Rham, Claudia de, Roeck, Albert De, Derr, Daniel, Di Pumpo, Fabio, Djordjevic, Goran S., Döbrich, Babette, Domokos, Peter, Dornan, Peter, Doser, Michael, Drougakis, Giannis, Dunningham, Jacob, Duspayev, Alisher, Easo, Sajan, Eby, Joshua, Efremov, Maxim, Ekelof, Tord, Elertas, Gedminas, Ellis, John, Evans, David, Fadeev, Pavel, Fanì, Mattia, Fassi, Farida, Fattori, Marco, Fayet, Pierre, Felea, Daniel, Feng, Jie, Friedrich, Alexander, Fuchs, Elina, Gaaloul, Naceur, Gao, Dongfeng, Gardner, Susan, Garraway, Barry, Gauguet, Alexandre, Gerlach, Sandra, Gersemann, Matthias, Gibson, Valerie, Giese, Enno, Giudice, Gian F., Glasbrenner, Eric P., Gündoğan, Mustafa, Haehnelt, Martin, Hakulinen, Timo, Hammerer, Klemens, Hanımeli, Ekim T., Harte, Tiffany, Hawkins, Leonie, Hees, Aurelien, Heise, Jaret, Henderson, Victoria A., Herrmann, Sven, Hird, Thomas M., Hogan, Jason M., Holst, Bodil, Holynski, Michael, Hussain, Kamran, Janson, Gregor, Jeglič, Peter, Jelezko, Fedor, Kagan, Michael, Kalliokoski, Matti, Kasevich, Mark, Kehagias, Alex, Kilian, Eva, Koley, Soumen, Konrad, Bernd, Kopp, Joachim, Kornakov, Georgy, Kovachy, Tim, Krutzik, Markus, Kumar, Mukesh, Kumar, Pradeep, Lämmerzahl, Claus, Landsberg, Greg, Langlois, Mehdi, Lanigan, Bryony, Lellouch, Samuel, Leone, Bruno, Poncin-Lafitte, Christophe Le, Lewicki, Marek, Leykauf, Bastian, Lezeik, Ali, Lombriser, Lucas, Luis Lopez-Gonzalez, J., Lopez Asamar, Elias, Monjaraz, Cristian López, Luciano, Giuseppe Gaetano, Mahmoud, M. A., Maleknejad, Azadeh, Marteau, Jacques, Massonnet, Didier, Mazumdar, Anupam, McCabe, Christopher, Meister, Matthias, Menu, Jonathan, Messineo, Giuseppe, Micalizio, Salvatore, Millington, Peter, Milosevic, Milan, Mitchell, Jeremiah, Montero, Mario, Morley, Gavin W., Müller, Jürgen, ioğlu, Özgür E. Müstecapl, Ni, Wei-Tou, Noller, Johannes, Odžak, Senad, Oi, Daniel K. L., Omar, Yasser, Pahl, Julia, Paling, Sean, Pandey, Saurabh, Pappas, George, Pareek, Vinay, Pasatembou, Elizabeth, Pelucchi, Emanuele, Pereira dos Santos, Franck, Piest, Baptist, Pikovski, Igor, Pilaftsis, Apostolos, Plunkett, Robert, Poggiani, Rosa, Prevedelli, Marco, Puputti, Julia, Veettil, Vishnupriya Puthiya, Quenby, John, Rafelski, Johann, Rajendran, Surjeet, Rasel, Ernst M., Sfar, Haifa Rejeb, Reynaud, Serge, Richaud, Andrea, Rodzinka, Tangui, Roura, Albert, Rudolph, Jan, Sabulsky, Dylan O., Safronova, Marianna S., Santamaria, Luigi, Schilling, Manuel, Schkolnik, Vladimir, Schleich, Wolfgang P., Schlippert, Dennis, Schneider, Ulrich, Schreck, Florian, Schubert, Christian, Schwersenz, Nico, Semakin, Aleksei, Sergijenko, Olga, Shao, Lijing, Shipsey, Ian, Singh, Rajeev, Smerzi, Augusto, Sopuerta, Carlos F., Spallicci, Alessandro D. A. M., Stefanescu, Petruta, Stergioulas, Nikolaos, Ströhle, Jannik, Struckmann, Christian, Tentindo, Silvia, Throssell, Henry, Tino, Guglielmo M., Tinsley, Jonathan N., Tintareanu Mircea, Ovidiu, Tkalčec, Kimberly, Tolley, Andrew. J., Tornatore, Vincenza, Torres-Orjuela, Alejandro, Treutlein, Philipp, Trombettoni, Andrea, Tsai, Yu-Dai, Ufrecht, Christian, Ulmer, Stefan, Valuch, Daniel, Vaskonen, Ville, Vázquez-Aceves, Verónica, Vitanov, Nikolay V., Vogt, Christian, Klitzing, Wolf von, Vukics, András, Walser, Reinhold, Wang, Jin, Warburton, Niels, Webber-Date, Alexander, Wenzlawski, André, Werner, Michael, Williams, Jason, Windpassinger, Patrick, Wolf, Peter, Woerner, Lisa, Xuereb, André, Yahia, Mohamed E., Cruzeiro, Emmanuel Zambrini, Zarei, Moslem, Zhan, Mingsheng, Zhou, Lin, Zupan, Jure, Zupanič, Erik, Abend, Sven, Allard, Baptiste, Alonso, Iván, Antoniadis, John, Araújo, Henrique, Arduini, Gianluigi, Arnold, Aidan S., Asano, Tobias, Augst, Nadja, Badurina, Leonardo, Balaž, Antun, Banks, Hannah, Barone, Michele, Barsanti, Michele, Bassi, Angelo, Battelier, Baptiste, Baynham, Charles F. A., Beaufils, Quentin, Belić, Aleksandar, Beniwal, Ankit, Bernabeu, Jose, Bertinelli, Francesco, Bertoldi, Andrea, Biswas, Ikbal Ahamed, Blas, Diego, Boegel, Patrick, Bogojević, Aleksandar, Böhm, Jonas, Böhringer, Samuel, Bongs, Kai, Bouyer, Philippe, Brand, Christian, Brimis, Apostolos, Buchmueller, Oliver, Cacciapuoti, Luigi, Calatroni, Sergio, Canuel, Benjamin, Caprini, Chiara, Caramete, Ana, Caramete, Laurentiu, Carlesso, Matteo, Carlton, John, Casariego, Mateo, Charmandaris, Vassilis, Chen, Yu-Ao, Chiofalo, Maria Luisa, Cimbri, Alessia, Coleman, Jonathon, Constantin, Florin Lucian, Contaldi, Carlo R., Cui, Yanou, Ros, Elisa Da, Davies, Gavin, Rosendo, Esther del Pino, Deppner, Christian, Derevianko, Andrei, Rham, Claudia de, Roeck, Albert De, Derr, Daniel, Di Pumpo, Fabio, Djordjevic, Goran S., Döbrich, Babette, Domokos, Peter, Dornan, Peter, Doser, Michael, Drougakis, Giannis, Dunningham, Jacob, Duspayev, Alisher, Easo, Sajan, Eby, Joshua, Efremov, Maxim, Ekelof, Tord, Elertas, Gedminas, Ellis, John, Evans, David, Fadeev, Pavel, Fanì, Mattia, Fassi, Farida, Fattori, Marco, Fayet, Pierre, Felea, Daniel, Feng, Jie, Friedrich, Alexander, Fuchs, Elina, Gaaloul, Naceur, Gao, Dongfeng, Gardner, Susan, Garraway, Barry, Gauguet, Alexandre, Gerlach, Sandra, Gersemann, Matthias, Gibson, Valerie, Giese, Enno, Giudice, Gian F., Glasbrenner, Eric P., Gündoğan, Mustafa, Haehnelt, Martin, Hakulinen, Timo, Hammerer, Klemens, Hanımeli, Ekim T., Harte, Tiffany, Hawkins, Leonie, Hees, Aurelien, Heise, Jaret, Henderson, Victoria A., Herrmann, Sven, Hird, Thomas M., Hogan, Jason M., Holst, Bodil, Holynski, Michael, Hussain, Kamran, Janson, Gregor, Jeglič, Peter, Jelezko, Fedor, Kagan, Michael, Kalliokoski, Matti, Kasevich, Mark, Kehagias, Alex, Kilian, Eva, Koley, Soumen, Konrad, Bernd, Kopp, Joachim, Kornakov, Georgy, Kovachy, Tim, Krutzik, Markus, Kumar, Mukesh, Kumar, Pradeep, Lämmerzahl, Claus, Landsberg, Greg, Langlois, Mehdi, Lanigan, Bryony, Lellouch, Samuel, Leone, Bruno, Poncin-Lafitte, Christophe Le, Lewicki, Marek, Leykauf, Bastian, Lezeik, Ali, Lombriser, Lucas, Luis Lopez-Gonzalez, J., Lopez Asamar, Elias, Monjaraz, Cristian López, Luciano, Giuseppe Gaetano, Mahmoud, M. A., Maleknejad, Azadeh, Marteau, Jacques, Massonnet, Didier, Mazumdar, Anupam, McCabe, Christopher, Meister, Matthias, Menu, Jonathan, Messineo, Giuseppe, Micalizio, Salvatore, Millington, Peter, Milosevic, Milan, Mitchell, Jeremiah, Montero, Mario, Morley, Gavin W., Müller, Jürgen, ioğlu, Özgür E. Müstecapl, Ni, Wei-Tou, Noller, Johannes, Odžak, Senad, Oi, Daniel K. L., Omar, Yasser, Pahl, Julia, Paling, Sean, Pandey, Saurabh, Pappas, George, Pareek, Vinay, Pasatembou, Elizabeth, Pelucchi, Emanuele, Pereira dos Santos, Franck, Piest, Baptist, Pikovski, Igor, Pilaftsis, Apostolos, Plunkett, Robert, Poggiani, Rosa, Prevedelli, Marco, Puputti, Julia, Veettil, Vishnupriya Puthiya, Quenby, John, Rafelski, Johann, Rajendran, Surjeet, Rasel, Ernst M., Sfar, Haifa Rejeb, Reynaud, Serge, Richaud, Andrea, Rodzinka, Tangui, Roura, Albert, Rudolph, Jan, Sabulsky, Dylan O., Safronova, Marianna S., Santamaria, Luigi, Schilling, Manuel, Schkolnik, Vladimir, Schleich, Wolfgang P., Schlippert, Dennis, Schneider, Ulrich, Schreck, Florian, Schubert, Christian, Schwersenz, Nico, Semakin, Aleksei, Sergijenko, Olga, Shao, Lijing, Shipsey, Ian, Singh, Rajeev, Smerzi, Augusto, Sopuerta, Carlos F., Spallicci, Alessandro D. A. M., Stefanescu, Petruta, Stergioulas, Nikolaos, Ströhle, Jannik, Struckmann, Christian, Tentindo, Silvia, Throssell, Henry, Tino, Guglielmo M., Tinsley, Jonathan N., Tintareanu Mircea, Ovidiu, Tkalčec, Kimberly, Tolley, Andrew. J., Tornatore, Vincenza, Torres-Orjuela, Alejandro, Treutlein, Philipp, Trombettoni, Andrea, Tsai, Yu-Dai, Ufrecht, Christian, Ulmer, Stefan, Valuch, Daniel, Vaskonen, Ville, Vázquez-Aceves, Verónica, Vitanov, Nikolay V., Vogt, Christian, Klitzing, Wolf von, Vukics, András, Walser, Reinhold, Wang, Jin, Warburton, Niels, Webber-Date, Alexander, Wenzlawski, André, Werner, Michael, Williams, Jason, Windpassinger, Patrick, Wolf, Peter, Woerner, Lisa, Xuereb, André, Yahia, Mohamed E., Cruzeiro, Emmanuel Zambrini, Zarei, Moslem, Zhan, Mingsheng, Zhou, Lin, Zupan, Jure, and Zupanič, Erik
Abstract: This document presents a summary of the 2023 Terrestrial Very-Long-Baseline Atom Interferometry Workshop hosted by CERN. The workshop brought together experts from around the world to discuss the exciting developments in large-scale atom interferometer (AI) prototypes and their potential for detecting ultralight dark matter and gravitational waves. The primary objective of the workshop was to lay the groundwork for an international TVLBAI proto-collaboration. This collaboration aims to unite researchers from different institutions to strategize and secure funding for terrestrial large-scale AI projects. The ultimate goal is to create a roadmap detailing the design and technology choices for one or more kilometer--scale detectors, which will be operational in the mid-2030s. The key sections of this report present the physics case and technical challenges, together with a comprehensive overview of the discussions at the workshop together with the main conclusions.
Published: 2024

36. Non-supersymmetric non-tachyonic heterotic vacua with reduced rank in various dimensions

Author: Angelantonj, Carlo, Florakis, Ioannis, Leone, Giorgio, Perugini, Diego, Angelantonj, Carlo, Florakis, Ioannis, Leone, Giorgio, and Perugini, Diego
Abstract: We construct rigid non-supersymmetric heterotic vacua with reduced rank and no tachyons in six and four dimensions. These configurations are based on asymmetric orbifold compactifications which do not admit deformation moduli and represent, to the best of our knowledge, the first instances of non-tachyonic non-supersymmetric heterotic vacua with reduced rank., Comment: 18 pages, 1 figure
Published: 2024

37. Aspects of Stability, Rigidity and Unitarity in String Vacua

Author: Leone, Giorgio and Leone, Giorgio
Abstract: In this Thesis we investigate properties of stability, rigidity and unitarity of the string landscape in ten and lower dimensions. The dissertation explores these aspects by intertwining a detailed analysis of string vacua, with and without supersymmetry, with a bottom-up study driven by unitarity. In particular, in Chapter 1 the possibility of formulating a necessary and sufficient condition for the classical stability of non-supersymmetric string vacua is discussed, emphasising the examples in ten and nine dimensions. In Chapter 2, new solutions are presented in six dimensions both for BSB and supersymmetric $T^4/\mathbb{Z}_6$ orientifold vacua, arising from a non-trivial cancellation of the R-R tadpoles. The consitency of these theories is shown by checking the cancellation of local anomalies and verifying the unitarity constraints arising from the introduction of string defects. Finally, Chapter 3 discusses the role played by a new kind of global anomaly, arising from the inconsistency of effective field theories under topology change. A systematic analysis of six-dimensional supergravity theories with $\text{SU}(2)$ gauge group and one tensor multiplet and $\text{U}(1)$ gauge group with no tensor multiplets is discussed. Novel constraints are found and their cancellation in string vacua is verified. In addition, we have investigated the $\text{SO}(16)\times \text{SO}(16)$ heterotic theory compactified on the $T^4/\mathbb{Z}_6$ orbifold and the Gepner orientifold with no tensor multiples, showing how such anomalies are cancelled. Even though expected, this result provides a non-trivial consistency check that is not guaranteed by any theorem known in the literature., Comment: PhD Thesis, 152 pages, 2 figures
Published: 2024

38. Species scale, worldsheet CFTs and emergent geometry

Author: Aoufia, Christian, Basile, Ivano, Leone, Giorgio, Aoufia, Christian, Basile, Ivano, and Leone, Giorgio
Abstract: We study infinite-distance limits in the moduli space of perturbative string vacua. The remarkable interplay of string dualities seems to determine a highly non-trivial dichotomy, summarized by the emergent string conjecture, by which in some duality frame either internal dimensions decompactify or a unique critical string becomes tensionless. Assuming the existence of light states, we investigate whether this pattern persists in potentially non-geometric settings, showing that (a proxy for) the cutoff of the gravitational effective field theory in perturbative type II vacua scales with the spectral gap of the internal conformal field theory in the same manner as in decompactification or emergent string limits, regardless of supersymmetry or whether the internal sector is geometric. As a byproduct, we elucidate the role of the species scale in (de)compactifications and show compatibility between effective field theory and worldsheet approaches in the presence of curvature deformations in geometric settings., Comment: 35 pages
Published: 2024

39. Gravitational back-reaction is magical

Author: Cao, ChunJun, Cheng, Gong, Hamma, Alioscia, Leone, Lorenzo, Munizzi, William, Oliviero, Savatore F. E., Cao, ChunJun, Cheng, Gong, Hamma, Alioscia, Leone, Lorenzo, Munizzi, William, and Oliviero, Savatore F. E.
Abstract: We study the interplay between magic and entanglement in quantum many-body systems. We show that non-local magic, which is supported by the quantum correlations is lower bounded by the non-flatness of entanglement spectrum and upper bounded by the amount of entanglement in the system. We then argue that a smoothed version of non-local magic bounds the hardness of classical simulations for incompressible states. In conformal field theories, we conjecture that the non-local magic should scale linearly with entanglement entropy but sublinearly when an approximation of the state is allowed. We support the conjectures using both analytical arguments based on unitary distillation and numerical data from an Ising CFT. If the CFT has a holographic dual, then we prove that the non-local magic vanishes if and only if there is no gravitational back-reaction. Furthermore, we show that non-local magic is approximately equal to the rate of change of the minimal surface area in response to the change of cosmic brane tension in the bulk., Comment: 62 pages, 20 figures; title changed, Theorem 1 and 2 refined, references added
Published: 2024

40. Breitbandige EMV-Analyse auf Grundlage eines modalen Full-Wave-Lösungsansatzes

Author: Garbe, Heyno, Schreiber, Hannes, Herwigk, Philipp, Leone, Marco, Garbe, Heyno, Schreiber, Hannes, Herwigk, Philipp, and Leone, Marco
Abstract: [no abstract available]
Published: 2024

41. Modale Netzwerkmodellierung elektrischer Verbindungsstrukturen auf Leiterplatten auf Basis der Momentenmethode

Author: Garbe, Heyno, Schulz, Phillip, Leone, Marco, Garbe, Heyno, Schulz, Phillip, and Leone, Marco
Abstract: [no abstract available]
Published: 2024

42. Beschleunigte elektromagnetische Modellierung resonanter Hohlraumstrukuren durch effiziente Abspaltung des statischen Unterraums

Author: Garbe, Heyno, Hamann, Chris-Marvin, Leone, Marco, Garbe, Heyno, Hamann, Chris-Marvin, and Leone, Marco
Abstract: [no abstract available]
Published: 2024

43. Exploring the administrative burden faced by hematologists: a comprehensive study in Italy

Author: Petruzzelli, Davide, Vignetti, Marco, Trasarti, Stefania, Sportoletti, Paolo, Della Torre, Silvia, Cairoli, Roberto, Leone, Francesca Pia Chiara, Pompilio, Giuseppe, Gullì, Marco, Brown Hajdukova, Eva, Integlia, Davide, Petruzzelli, Davide, Vignetti, Marco, Trasarti, Stefania, Sportoletti, Paolo, Della Torre, Silvia, Cairoli, Roberto, Leone, Francesca Pia Chiara, Pompilio, Giuseppe, Gullì, Marco, Brown Hajdukova, Eva, and Integlia, Davide
Abstract: Background: Administrative burdens have been identified as a major issue impacting patient care, professional practice, and the overall efficiency of healthcare systems. The aim of this study is to assess the administrative burden faced by Italian hematologists. Methods: A cross-sectional survey that included both closed-ended quantitative questions and open-ended free text answer options was administered to 1,570 hematologists working with malignancies and members of Italian GIMEMA Foundation – Franco Mandelli ONLUS and the Italian Linfomi Foundation (FIL). The survey was conducted online from May 24 to June 30, 2023. Descriptive statistics were computed for the quantitative data to clearly summarize the responses and descriptive analysis of free text responses was carried out. Results: Surveyed hematologists spend an average of 47.07% of their time on administrative tasks, with 63.22% (n = 110) of respondents reporting spending at least half of their time on these activities. More than half (57.47%, n = 100) reported that “Patient care” is the medical task most affected by a lack of time. Additionally, 55.17% (n = 96) reported experiencing burnout in the past 6 months, with filling out “Forms” being identified as the top contributing administrative task by 27.59% (n = 48) of respondents, followed by “Scheduling” (24.71%, n = 43) and “Managing IT system failures” (21.84%, n = 38). Nearly half of the surveyed hematologists (45.40%, n = = 79) identified patient care as the top priority requiring more time. Conclusions: The study confirms that the administrative workload of hematologists has a significant impact on patient care, communication, and burnout risk, reducing the time available for patient care, leading to exhaustion and concern about clinical errors.
Published: 2024

44. Intravascular Ultrasound in the Detection of Bridging Stent Graft Instability During Fenestrated and Branched Endovascular Aneurysm Repair Procedures : A Multicentre Study on 274 Target Vessels

Author: Asciutto, Giuseppe, Ibrahim, Abdulhakim, Leone, Nicola, Gennai, Stefano, Piazza, Michele, Antonello, Michele, Wanhainen, Anders, Mani, Kevin, Lindström, David, Struk, Lisa, Oberhuber, Alexander, Asciutto, Giuseppe, Ibrahim, Abdulhakim, Leone, Nicola, Gennai, Stefano, Piazza, Michele, Antonello, Michele, Wanhainen, Anders, Mani, Kevin, Lindström, David, Struk, Lisa, and Oberhuber, Alexander
Abstract: OBJECTIVE: The use of intravascular ultrasound (IVUS) reduces contrast medium use and radiation exposure during conventional endovascular aneurysm repair (EVAR). The aim of this study was to evaluate the safety and efficacy of IVUS in detecting bridging stent graft (bSG) instability during fenestrated and branched EVAR (F/B-EVAR). METHODS: This was a prospective observational multicentre study. The following outcomes were evaluated: (1) technical success of the IVUS in each bSG, (2) IVUS findings compared with intra-operative angiography, (3) incidence of post-operative computed tomography angiography (CTA) findings not detected with IVUS, and (4) absence of IVUS related adverse events. Target visceral vessel (TVV) instability was defined as any branch or fenestration issues requiring an additional manoeuvre or re-intervention. Any IVUS assessment that detected stenosis, kinking, or any geometric TVV issue was considered to be branch instability. All procedures were performed in ad hoc hybrid rooms. RESULTS: Eighty patients (69% males; median age 72 years; interquartile range 59, 77 years) from four aortic centres treated with F/B-EVAR between January 2019 and September 2021 were included: 70 BEVAR (21 off the shelf; 49 custom made), eight FEVAR (custom made), and two F/B-EVAR (custom made), for a total of 300 potential TVVs. Two TVVs (0.7%) were left unstented and excluded from the analysis. The TVVs could not be accessed with the IVUS catheter in seven cases (2.3%). Furthermore, 17 (5.7%) TVVs could not be examined due to a malfunction of the IVUS catheter. The technical success of the IVUS assessment was 91.9% (274/298), with no IVUS related adverse events. Seven TVVs (2.5%) showed signs of bSG instability by means of IVUS, leading to immediate revisions. The first post-operative CTA at least 30 days after the index procedure was available in 268 of the 274 TVVs originally assessed by IVUS. In seven of the 268 TVVs (2.6%) a re-intervention became necessary due to
Published: 2024
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45. Terrestrial very-long-baseline atom interferometry : Workshop summary

Author: Abend, Sven, Allard, Baptiste, Alonso, Iván, Antoniadis, John, Araújo, Henrique, Arduini, Gianluigi, Arnold, Aidan S., Asano, Tobias, Augst, Nadja, Badurina, Leonardo, Balaz, Antun, Banks, Hannah, Barone, Michele, Barsanti, Michele, Bassi, Angelo, Battelier, Baptiste, Baynham, Charles F. A., Beaufils, Quentin, Belic, Aleksandar, Beniwal, Ankit, Bernabeu, Jose, Bertinelli, Francesco, Bertoldi, Andrea, Biswas, Ikbal Ahamed, Blas, Diego, Boegel, Patrick, Bogojevic, Aleksandar, Böhm, Jonas, Böhringer, Samuel, Bongs, Kai, Bouyer, Philippe, Brand, Christian, Brimis, Apostolos, Buchmueller, Oliver, Cacciapuoti, Luigi, Calatroni, Sergio, Canuel, Benjamin, Caprini, Chiara, Caramete, Ana, Caramete, Laurentiu, Carlesso, Matteo, Carlton, John, Casariego, Mateo, Charmandaris, Vassilis, Chen, Yu-Ao, Chiofalo, Maria Luisa, Cimbri, Alessia, Coleman, Jonathon, Constantin, Florin Lucian, Contaldi, Carlo R., Cui, Yanou, Ros, Elisa Da, Davies, Gavin, del Pino Rosendo, Esther, Deppner, Christian, Derevianko, Andrei, de Rham, Claudia, De Roeck, Albert, Derr, Daniel, Di Pumpo, Fabio, Djordjevic, Goran S., Döbrich, Babette, Domokos, Peter, Dornan, Peter, Doser, Michael, Drougakis, Giannis, Dunningham, Jacob, Duspayev, Alisher, Easo, Sajan, Eby, Joshua, Efremov, Maxim, Ekelöf, Tord, Elertas, Gedminas, Ellis, John, Evans, David, Fadeev, Pavel, Fani, Mattia, Fassi, Farida, Fattori, Marco, Fayet, Pierre, Felea, Daniel, Feng, Jie, Friedrich, Alexander, Fuchs, Elina, Gaaloul, Naceur, Gao, Dongfeng, Gardner, Susan, Garraway, Barry, Gauguet, Alexandre, Gerlach, Sandra, Gersemann, Matthias, Gibson, Valerie, Giese, Enno, Giudice, Gian F., Glasbrenner, Eric P., Gündogan, Mustafa, Haehnelt, Martin, Hakulinen, Timo, Hammerer, Klemens, Hanimeli, Ekim T., Harte, Tiffany, Hawkins, Leonie, Hees, Aurelien, Heise, Jaret, Henderson, Victoria A., Herrmann, Sven, Hird, Thomas M., Hogan, Jason M., Holst, Bodil, Holynski, Michael, Hussain, Kamran, Janson, Gregor, Jeglic, Peter, Jelezko, Fedor, Kagan, Michael, Kalliokoski, Matti, Kasevich, Mark, Kehagias, Alex, Kilian, Eva, Koley, Soumen, Konrad, Bernd, Kopp, Joachim, Kornakov, Georgy, Kovachy, Tim, Krutzik, Markus, Kumar, Mukesh, Kumar, Pradeep, Lämmerzahl, Claus, Landsberg, Greg, Langlois, Mehdi, Lanigan, Bryony, Lellouch, Samuel, Leone, Bruno, Poncin-Lafitte, Christophe Le, Lewicki, Marek, Leykauf, Bastian, Lezeik, Ali, Lombriser, Lucas, Luis Lopez-Gonzalez, J., Lopez Asamar, Elias, López Monjaraz, Cristian, Luciano, Giuseppe Gaetano, Mahmoud, M. A., Maleknejad, Azadeh, Marteau, Jacques, Massonnet, Didier, Mazumdar, Anupam, McCabe, Christopher, Meister, Matthias, Menu, Jonathan, Messineo, Giuseppe, Micalizio, Salvatore, Millington, Peter, Milosevic, Milan, Mitchell, Jeremiah, Montero, Mario, Morley, Gavin W., Müller, Jürgen, Müstecaploglu, Özgür E., Ni, Wei-Tou, Noller, Johannes, Odzak, Senad, Oi, Daniel K. L., Omar, Yasser, Pahl, Julia, Paling, Sean, Pandey, Saurabh, Pappas, George, Pareek, Vinay, Pasatembou, Elizabeth, Pelucchi, Emanuele, Pereira dos Santos, Franck, Piest, Baptist, Pikovski, Igor, Pilaftsis, Apostolos, Plunkett, Robert, Poggiani, Rosa, Prevedelli, Marco, Puputti, Julia, Veettil, Vishnupriya Puthiya, Quenby, John, Rafelski, Johann, Rajendran, Surjeet, Rasel, Ernst M., Sfar, Haifa Rejeb, Reynaud, Serge, Richaud, Andrea, Rodzinka, Tangui, Roura, Albert, Rudolph, Jan, Sabulsky, Dylan O., Safronova, Marianna S., Santamaria, Luigi, Schilling, Manuel, Schkolnik, Vladimir, Schleich, Wolfgang P., Schlippert, Dennis, Schneider, Ulrich, Schreck, Florian, Schubert, Christian, Schwersenz, Nico, Semakin, Aleksei, Sergijenko, Olga, Shao, Lijing, Shipsey, Ian, Singh, Rajeev, Smerzi, Augusto, Sopuerta, Carlos F., Spallicci, Alessandro D. A. M., Stefanescu, Petruta, Stergioulas, Nikolaos, Ströhle, Jannik, Struckmann, Christian, Tentindo, Silvia, Throssell, Henry, Tino, Guglielmo M., Tinsley, Jonathan N., Tintareanu Mircea, Ovidiu, Tkalcec, Kimberly, Tolley, Andrew J., Tornatore, Vincenza, Torres-Orjuela, Alejandro, Treutlein, Philipp, Trombettoni, Andrea, Tsai, Yu-Dai, Ufrecht, Christian, Ulmer, Stefan, Valuch, Daniel, Vaskonen, Ville, Vázquez-Aceves, Verónica, Vitanov, Nikolay V., Vogt, Christian, von Klitzing, Wolf, Vukics, András, Walser, Reinhold, Wang, Jin, Warburton, Niels, Webber-Date, Alexander, Wenzlawski, André, Werner, Michael, Williams, Jason, Windpassinger, Patrick, Wolf, Peter, Woerner, Lisa, Xuereb, André, Yahia, Mohamed E., Zambrini Cruzeiro, Emmanuel, Zarei, Moslem, Zhan, Mingsheng, Zhou, Lin, Zupan, Jure, Zupanic, Erik, Abend, Sven, Allard, Baptiste, Alonso, Iván, Antoniadis, John, Araújo, Henrique, Arduini, Gianluigi, Arnold, Aidan S., Asano, Tobias, Augst, Nadja, Badurina, Leonardo, Balaz, Antun, Banks, Hannah, Barone, Michele, Barsanti, Michele, Bassi, Angelo, Battelier, Baptiste, Baynham, Charles F. A., Beaufils, Quentin, Belic, Aleksandar, Beniwal, Ankit, Bernabeu, Jose, Bertinelli, Francesco, Bertoldi, Andrea, Biswas, Ikbal Ahamed, Blas, Diego, Boegel, Patrick, Bogojevic, Aleksandar, Böhm, Jonas, Böhringer, Samuel, Bongs, Kai, Bouyer, Philippe, Brand, Christian, Brimis, Apostolos, Buchmueller, Oliver, Cacciapuoti, Luigi, Calatroni, Sergio, Canuel, Benjamin, Caprini, Chiara, Caramete, Ana, Caramete, Laurentiu, Carlesso, Matteo, Carlton, John, Casariego, Mateo, Charmandaris, Vassilis, Chen, Yu-Ao, Chiofalo, Maria Luisa, Cimbri, Alessia, Coleman, Jonathon, Constantin, Florin Lucian, Contaldi, Carlo R., Cui, Yanou, Ros, Elisa Da, Davies, Gavin, del Pino Rosendo, Esther, Deppner, Christian, Derevianko, Andrei, de Rham, Claudia, De Roeck, Albert, Derr, Daniel, Di Pumpo, Fabio, Djordjevic, Goran S., Döbrich, Babette, Domokos, Peter, Dornan, Peter, Doser, Michael, Drougakis, Giannis, Dunningham, Jacob, Duspayev, Alisher, Easo, Sajan, Eby, Joshua, Efremov, Maxim, Ekelöf, Tord, Elertas, Gedminas, Ellis, John, Evans, David, Fadeev, Pavel, Fani, Mattia, Fassi, Farida, Fattori, Marco, Fayet, Pierre, Felea, Daniel, Feng, Jie, Friedrich, Alexander, Fuchs, Elina, Gaaloul, Naceur, Gao, Dongfeng, Gardner, Susan, Garraway, Barry, Gauguet, Alexandre, Gerlach, Sandra, Gersemann, Matthias, Gibson, Valerie, Giese, Enno, Giudice, Gian F., Glasbrenner, Eric P., Gündogan, Mustafa, Haehnelt, Martin, Hakulinen, Timo, Hammerer, Klemens, Hanimeli, Ekim T., Harte, Tiffany, Hawkins, Leonie, Hees, Aurelien, Heise, Jaret, Henderson, Victoria A., Herrmann, Sven, Hird, Thomas M., Hogan, Jason M., Holst, Bodil, Holynski, Michael, Hussain, Kamran, Janson, Gregor, Jeglic, Peter, Jelezko, Fedor, Kagan, Michael, Kalliokoski, Matti, Kasevich, Mark, Kehagias, Alex, Kilian, Eva, Koley, Soumen, Konrad, Bernd, Kopp, Joachim, Kornakov, Georgy, Kovachy, Tim, Krutzik, Markus, Kumar, Mukesh, Kumar, Pradeep, Lämmerzahl, Claus, Landsberg, Greg, Langlois, Mehdi, Lanigan, Bryony, Lellouch, Samuel, Leone, Bruno, Poncin-Lafitte, Christophe Le, Lewicki, Marek, Leykauf, Bastian, Lezeik, Ali, Lombriser, Lucas, Luis Lopez-Gonzalez, J., Lopez Asamar, Elias, López Monjaraz, Cristian, Luciano, Giuseppe Gaetano, Mahmoud, M. A., Maleknejad, Azadeh, Marteau, Jacques, Massonnet, Didier, Mazumdar, Anupam, McCabe, Christopher, Meister, Matthias, Menu, Jonathan, Messineo, Giuseppe, Micalizio, Salvatore, Millington, Peter, Milosevic, Milan, Mitchell, Jeremiah, Montero, Mario, Morley, Gavin W., Müller, Jürgen, Müstecaploglu, Özgür E., Ni, Wei-Tou, Noller, Johannes, Odzak, Senad, Oi, Daniel K. L., Omar, Yasser, Pahl, Julia, Paling, Sean, Pandey, Saurabh, Pappas, George, Pareek, Vinay, Pasatembou, Elizabeth, Pelucchi, Emanuele, Pereira dos Santos, Franck, Piest, Baptist, Pikovski, Igor, Pilaftsis, Apostolos, Plunkett, Robert, Poggiani, Rosa, Prevedelli, Marco, Puputti, Julia, Veettil, Vishnupriya Puthiya, Quenby, John, Rafelski, Johann, Rajendran, Surjeet, Rasel, Ernst M., Sfar, Haifa Rejeb, Reynaud, Serge, Richaud, Andrea, Rodzinka, Tangui, Roura, Albert, Rudolph, Jan, Sabulsky, Dylan O., Safronova, Marianna S., Santamaria, Luigi, Schilling, Manuel, Schkolnik, Vladimir, Schleich, Wolfgang P., Schlippert, Dennis, Schneider, Ulrich, Schreck, Florian, Schubert, Christian, Schwersenz, Nico, Semakin, Aleksei, Sergijenko, Olga, Shao, Lijing, Shipsey, Ian, Singh, Rajeev, Smerzi, Augusto, Sopuerta, Carlos F., Spallicci, Alessandro D. A. M., Stefanescu, Petruta, Stergioulas, Nikolaos, Ströhle, Jannik, Struckmann, Christian, Tentindo, Silvia, Throssell, Henry, Tino, Guglielmo M., Tinsley, Jonathan N., Tintareanu Mircea, Ovidiu, Tkalcec, Kimberly, Tolley, Andrew J., Tornatore, Vincenza, Torres-Orjuela, Alejandro, Treutlein, Philipp, Trombettoni, Andrea, Tsai, Yu-Dai, Ufrecht, Christian, Ulmer, Stefan, Valuch, Daniel, Vaskonen, Ville, Vázquez-Aceves, Verónica, Vitanov, Nikolay V., Vogt, Christian, von Klitzing, Wolf, Vukics, András, Walser, Reinhold, Wang, Jin, Warburton, Niels, Webber-Date, Alexander, Wenzlawski, André, Werner, Michael, Williams, Jason, Windpassinger, Patrick, Wolf, Peter, Woerner, Lisa, Xuereb, André, Yahia, Mohamed E., Zambrini Cruzeiro, Emmanuel, Zarei, Moslem, Zhan, Mingsheng, Zhou, Lin, Zupan, Jure, and Zupanic, Erik
Abstract: This document presents a summary of the 2023 Terrestrial Very-Long-Baseline Atom Interferometry Workshop hosted by CERN. The workshop brought together experts from around the world to discuss the exciting developments in large-scale atom interferometer (AI) prototypes and their potential for detecting ultralight dark matter and gravitational waves. The primary objective of the workshop was to lay the groundwork for an international TVLBAI proto-collaboration. This collaboration aims to unite researchers from different institutions to strategize and secure funding for terrestrial large-scale AI projects. The ultimate goal is to create a roadmap detailing the design and technology choices for one or more kilometer--scale detectors, which will be operational in the mid-2030s. The key sections of this report present the physics case and technical challenges, together with a comprehensive overview of the discussions at the workshop together with the main conclusions.
Published: 2024
Full Text: View/download PDF

46. Terrestrial very-long-baseline atom interferometry : Workshop summary

Author: Abend, Sven, Allard, Baptiste, Alonso, Iván, Antoniadis, John, Araújo, Henrique, Arduini, Gianluigi, Arnold, Aidan S., Asano, Tobias, Augst, Nadja, Badurina, Leonardo, Balaz, Antun, Banks, Hannah, Barone, Michele, Barsanti, Michele, Bassi, Angelo, Battelier, Baptiste, Baynham, Charles F. A., Beaufils, Quentin, Belic, Aleksandar, Beniwal, Ankit, Bernabeu, Jose, Bertinelli, Francesco, Bertoldi, Andrea, Biswas, Ikbal Ahamed, Blas, Diego, Boegel, Patrick, Bogojevic, Aleksandar, Böhm, Jonas, Böhringer, Samuel, Bongs, Kai, Bouyer, Philippe, Brand, Christian, Brimis, Apostolos, Buchmueller, Oliver, Cacciapuoti, Luigi, Calatroni, Sergio, Canuel, Benjamin, Caprini, Chiara, Caramete, Ana, Caramete, Laurentiu, Carlesso, Matteo, Carlton, John, Casariego, Mateo, Charmandaris, Vassilis, Chen, Yu-Ao, Chiofalo, Maria Luisa, Cimbri, Alessia, Coleman, Jonathon, Constantin, Florin Lucian, Contaldi, Carlo R., Cui, Yanou, Ros, Elisa Da, Davies, Gavin, del Pino Rosendo, Esther, Deppner, Christian, Derevianko, Andrei, de Rham, Claudia, De Roeck, Albert, Derr, Daniel, Di Pumpo, Fabio, Djordjevic, Goran S., Döbrich, Babette, Domokos, Peter, Dornan, Peter, Doser, Michael, Drougakis, Giannis, Dunningham, Jacob, Duspayev, Alisher, Easo, Sajan, Eby, Joshua, Efremov, Maxim, Ekelöf, Tord, Elertas, Gedminas, Ellis, John, Evans, David, Fadeev, Pavel, Fani, Mattia, Fassi, Farida, Fattori, Marco, Fayet, Pierre, Felea, Daniel, Feng, Jie, Friedrich, Alexander, Fuchs, Elina, Gaaloul, Naceur, Gao, Dongfeng, Gardner, Susan, Garraway, Barry, Gauguet, Alexandre, Gerlach, Sandra, Gersemann, Matthias, Gibson, Valerie, Giese, Enno, Giudice, Gian F., Glasbrenner, Eric P., Gündogan, Mustafa, Haehnelt, Martin, Hakulinen, Timo, Hammerer, Klemens, Hanimeli, Ekim T., Harte, Tiffany, Hawkins, Leonie, Hees, Aurelien, Heise, Jaret, Henderson, Victoria A., Herrmann, Sven, Hird, Thomas M., Hogan, Jason M., Holst, Bodil, Holynski, Michael, Hussain, Kamran, Janson, Gregor, Jeglic, Peter, Jelezko, Fedor, Kagan, Michael, Kalliokoski, Matti, Kasevich, Mark, Kehagias, Alex, Kilian, Eva, Koley, Soumen, Konrad, Bernd, Kopp, Joachim, Kornakov, Georgy, Kovachy, Tim, Krutzik, Markus, Kumar, Mukesh, Kumar, Pradeep, Lämmerzahl, Claus, Landsberg, Greg, Langlois, Mehdi, Lanigan, Bryony, Lellouch, Samuel, Leone, Bruno, Poncin-Lafitte, Christophe Le, Lewicki, Marek, Leykauf, Bastian, Lezeik, Ali, Lombriser, Lucas, Luis Lopez-Gonzalez, J., Lopez Asamar, Elias, López Monjaraz, Cristian, Luciano, Giuseppe Gaetano, Mahmoud, M. A., Maleknejad, Azadeh, Marteau, Jacques, Massonnet, Didier, Mazumdar, Anupam, McCabe, Christopher, Meister, Matthias, Menu, Jonathan, Messineo, Giuseppe, Micalizio, Salvatore, Millington, Peter, Milosevic, Milan, Mitchell, Jeremiah, Montero, Mario, Morley, Gavin W., Müller, Jürgen, Müstecaploglu, Özgür E., Ni, Wei-Tou, Noller, Johannes, Odzak, Senad, Oi, Daniel K. L., Omar, Yasser, Pahl, Julia, Paling, Sean, Pandey, Saurabh, Pappas, George, Pareek, Vinay, Pasatembou, Elizabeth, Pelucchi, Emanuele, Pereira dos Santos, Franck, Piest, Baptist, Pikovski, Igor, Pilaftsis, Apostolos, Plunkett, Robert, Poggiani, Rosa, Prevedelli, Marco, Puputti, Julia, Veettil, Vishnupriya Puthiya, Quenby, John, Rafelski, Johann, Rajendran, Surjeet, Rasel, Ernst M., Sfar, Haifa Rejeb, Reynaud, Serge, Richaud, Andrea, Rodzinka, Tangui, Roura, Albert, Rudolph, Jan, Sabulsky, Dylan O., Safronova, Marianna S., Santamaria, Luigi, Schilling, Manuel, Schkolnik, Vladimir, Schleich, Wolfgang P., Schlippert, Dennis, Schneider, Ulrich, Schreck, Florian, Schubert, Christian, Schwersenz, Nico, Semakin, Aleksei, Sergijenko, Olga, Shao, Lijing, Shipsey, Ian, Singh, Rajeev, Smerzi, Augusto, Sopuerta, Carlos F., Spallicci, Alessandro D. A. M., Stefanescu, Petruta, Stergioulas, Nikolaos, Ströhle, Jannik, Struckmann, Christian, Tentindo, Silvia, Throssell, Henry, Tino, Guglielmo M., Tinsley, Jonathan N., Tintareanu Mircea, Ovidiu, Tkalcec, Kimberly, Tolley, Andrew J., Tornatore, Vincenza, Torres-Orjuela, Alejandro, Treutlein, Philipp, Trombettoni, Andrea, Tsai, Yu-Dai, Ufrecht, Christian, Ulmer, Stefan, Valuch, Daniel, Vaskonen, Ville, Vázquez-Aceves, Verónica, Vitanov, Nikolay V., Vogt, Christian, von Klitzing, Wolf, Vukics, András, Walser, Reinhold, Wang, Jin, Warburton, Niels, Webber-Date, Alexander, Wenzlawski, André, Werner, Michael, Williams, Jason, Windpassinger, Patrick, Wolf, Peter, Woerner, Lisa, Xuereb, André, Yahia, Mohamed E., Zambrini Cruzeiro, Emmanuel, Zarei, Moslem, Zhan, Mingsheng, Zhou, Lin, Zupan, Jure, Zupanic, Erik, Abend, Sven, Allard, Baptiste, Alonso, Iván, Antoniadis, John, Araújo, Henrique, Arduini, Gianluigi, Arnold, Aidan S., Asano, Tobias, Augst, Nadja, Badurina, Leonardo, Balaz, Antun, Banks, Hannah, Barone, Michele, Barsanti, Michele, Bassi, Angelo, Battelier, Baptiste, Baynham, Charles F. A., Beaufils, Quentin, Belic, Aleksandar, Beniwal, Ankit, Bernabeu, Jose, Bertinelli, Francesco, Bertoldi, Andrea, Biswas, Ikbal Ahamed, Blas, Diego, Boegel, Patrick, Bogojevic, Aleksandar, Böhm, Jonas, Böhringer, Samuel, Bongs, Kai, Bouyer, Philippe, Brand, Christian, Brimis, Apostolos, Buchmueller, Oliver, Cacciapuoti, Luigi, Calatroni, Sergio, Canuel, Benjamin, Caprini, Chiara, Caramete, Ana, Caramete, Laurentiu, Carlesso, Matteo, Carlton, John, Casariego, Mateo, Charmandaris, Vassilis, Chen, Yu-Ao, Chiofalo, Maria Luisa, Cimbri, Alessia, Coleman, Jonathon, Constantin, Florin Lucian, Contaldi, Carlo R., Cui, Yanou, Ros, Elisa Da, Davies, Gavin, del Pino Rosendo, Esther, Deppner, Christian, Derevianko, Andrei, de Rham, Claudia, De Roeck, Albert, Derr, Daniel, Di Pumpo, Fabio, Djordjevic, Goran S., Döbrich, Babette, Domokos, Peter, Dornan, Peter, Doser, Michael, Drougakis, Giannis, Dunningham, Jacob, Duspayev, Alisher, Easo, Sajan, Eby, Joshua, Efremov, Maxim, Ekelöf, Tord, Elertas, Gedminas, Ellis, John, Evans, David, Fadeev, Pavel, Fani, Mattia, Fassi, Farida, Fattori, Marco, Fayet, Pierre, Felea, Daniel, Feng, Jie, Friedrich, Alexander, Fuchs, Elina, Gaaloul, Naceur, Gao, Dongfeng, Gardner, Susan, Garraway, Barry, Gauguet, Alexandre, Gerlach, Sandra, Gersemann, Matthias, Gibson, Valerie, Giese, Enno, Giudice, Gian F., Glasbrenner, Eric P., Gündogan, Mustafa, Haehnelt, Martin, Hakulinen, Timo, Hammerer, Klemens, Hanimeli, Ekim T., Harte, Tiffany, Hawkins, Leonie, Hees, Aurelien, Heise, Jaret, Henderson, Victoria A., Herrmann, Sven, Hird, Thomas M., Hogan, Jason M., Holst, Bodil, Holynski, Michael, Hussain, Kamran, Janson, Gregor, Jeglic, Peter, Jelezko, Fedor, Kagan, Michael, Kalliokoski, Matti, Kasevich, Mark, Kehagias, Alex, Kilian, Eva, Koley, Soumen, Konrad, Bernd, Kopp, Joachim, Kornakov, Georgy, Kovachy, Tim, Krutzik, Markus, Kumar, Mukesh, Kumar, Pradeep, Lämmerzahl, Claus, Landsberg, Greg, Langlois, Mehdi, Lanigan, Bryony, Lellouch, Samuel, Leone, Bruno, Poncin-Lafitte, Christophe Le, Lewicki, Marek, Leykauf, Bastian, Lezeik, Ali, Lombriser, Lucas, Luis Lopez-Gonzalez, J., Lopez Asamar, Elias, López Monjaraz, Cristian, Luciano, Giuseppe Gaetano, Mahmoud, M. A., Maleknejad, Azadeh, Marteau, Jacques, Massonnet, Didier, Mazumdar, Anupam, McCabe, Christopher, Meister, Matthias, Menu, Jonathan, Messineo, Giuseppe, Micalizio, Salvatore, Millington, Peter, Milosevic, Milan, Mitchell, Jeremiah, Montero, Mario, Morley, Gavin W., Müller, Jürgen, Müstecaploglu, Özgür E., Ni, Wei-Tou, Noller, Johannes, Odzak, Senad, Oi, Daniel K. L., Omar, Yasser, Pahl, Julia, Paling, Sean, Pandey, Saurabh, Pappas, George, Pareek, Vinay, Pasatembou, Elizabeth, Pelucchi, Emanuele, Pereira dos Santos, Franck, Piest, Baptist, Pikovski, Igor, Pilaftsis, Apostolos, Plunkett, Robert, Poggiani, Rosa, Prevedelli, Marco, Puputti, Julia, Veettil, Vishnupriya Puthiya, Quenby, John, Rafelski, Johann, Rajendran, Surjeet, Rasel, Ernst M., Sfar, Haifa Rejeb, Reynaud, Serge, Richaud, Andrea, Rodzinka, Tangui, Roura, Albert, Rudolph, Jan, Sabulsky, Dylan O., Safronova, Marianna S., Santamaria, Luigi, Schilling, Manuel, Schkolnik, Vladimir, Schleich, Wolfgang P., Schlippert, Dennis, Schneider, Ulrich, Schreck, Florian, Schubert, Christian, Schwersenz, Nico, Semakin, Aleksei, Sergijenko, Olga, Shao, Lijing, Shipsey, Ian, Singh, Rajeev, Smerzi, Augusto, Sopuerta, Carlos F., Spallicci, Alessandro D. A. M., Stefanescu, Petruta, Stergioulas, Nikolaos, Ströhle, Jannik, Struckmann, Christian, Tentindo, Silvia, Throssell, Henry, Tino, Guglielmo M., Tinsley, Jonathan N., Tintareanu Mircea, Ovidiu, Tkalcec, Kimberly, Tolley, Andrew J., Tornatore, Vincenza, Torres-Orjuela, Alejandro, Treutlein, Philipp, Trombettoni, Andrea, Tsai, Yu-Dai, Ufrecht, Christian, Ulmer, Stefan, Valuch, Daniel, Vaskonen, Ville, Vázquez-Aceves, Verónica, Vitanov, Nikolay V., Vogt, Christian, von Klitzing, Wolf, Vukics, András, Walser, Reinhold, Wang, Jin, Warburton, Niels, Webber-Date, Alexander, Wenzlawski, André, Werner, Michael, Williams, Jason, Windpassinger, Patrick, Wolf, Peter, Woerner, Lisa, Xuereb, André, Yahia, Mohamed E., Zambrini Cruzeiro, Emmanuel, Zarei, Moslem, Zhan, Mingsheng, Zhou, Lin, Zupan, Jure, and Zupanic, Erik
Abstract: This document presents a summary of the 2023 Terrestrial Very-Long-Baseline Atom Interferometry Workshop hosted by CERN. The workshop brought together experts from around the world to discuss the exciting developments in large-scale atom interferometer (AI) prototypes and their potential for detecting ultralight dark matter and gravitational waves. The primary objective of the workshop was to lay the groundwork for an international TVLBAI proto-collaboration. This collaboration aims to unite researchers from different institutions to strategize and secure funding for terrestrial large-scale AI projects. The ultimate goal is to create a roadmap detailing the design and technology choices for one or more kilometer--scale detectors, which will be operational in the mid-2030s. The key sections of this report present the physics case and technical challenges, together with a comprehensive overview of the discussions at the workshop together with the main conclusions.
Published: 2024
Full Text: View/download PDF

47. Intravascular Ultrasound in the Detection of Bridging Stent Graft Instability During Fenestrated and Branched Endovascular Aneurysm Repair Procedures : A Multicentre Study on 274 Target Vessels

Author: Asciutto, Giuseppe, Ibrahim, Abdulhakim, Leone, Nicola, Gennai, Stefano, Piazza, Michele, Antonello, Michele, Wanhainen, Anders, Mani, Kevin, Lindström, David, Struk, Lisa, Oberhuber, Alexander, Asciutto, Giuseppe, Ibrahim, Abdulhakim, Leone, Nicola, Gennai, Stefano, Piazza, Michele, Antonello, Michele, Wanhainen, Anders, Mani, Kevin, Lindström, David, Struk, Lisa, and Oberhuber, Alexander
Abstract: OBJECTIVE: The use of intravascular ultrasound (IVUS) reduces contrast medium use and radiation exposure during conventional endovascular aneurysm repair (EVAR). The aim of this study was to evaluate the safety and efficacy of IVUS in detecting bridging stent graft (bSG) instability during fenestrated and branched EVAR (F/B-EVAR). METHODS: This was a prospective observational multicentre study. The following outcomes were evaluated: (1) technical success of the IVUS in each bSG, (2) IVUS findings compared with intra-operative angiography, (3) incidence of post-operative computed tomography angiography (CTA) findings not detected with IVUS, and (4) absence of IVUS related adverse events. Target visceral vessel (TVV) instability was defined as any branch or fenestration issues requiring an additional manoeuvre or re-intervention. Any IVUS assessment that detected stenosis, kinking, or any geometric TVV issue was considered to be branch instability. All procedures were performed in ad hoc hybrid rooms. RESULTS: Eighty patients (69% males; median age 72 years; interquartile range 59, 77 years) from four aortic centres treated with F/B-EVAR between January 2019 and September 2021 were included: 70 BEVAR (21 off the shelf; 49 custom made), eight FEVAR (custom made), and two F/B-EVAR (custom made), for a total of 300 potential TVVs. Two TVVs (0.7%) were left unstented and excluded from the analysis. The TVVs could not be accessed with the IVUS catheter in seven cases (2.3%). Furthermore, 17 (5.7%) TVVs could not be examined due to a malfunction of the IVUS catheter. The technical success of the IVUS assessment was 91.9% (274/298), with no IVUS related adverse events. Seven TVVs (2.5%) showed signs of bSG instability by means of IVUS, leading to immediate revisions. The first post-operative CTA at least 30 days after the index procedure was available in 268 of the 274 TVVs originally assessed by IVUS. In seven of the 268 TVVs (2.6%) a re-intervention became necessary due to
Published: 2024
Full Text: View/download PDF

48. Terrestrial very-long-baseline atom interferometry : Workshop summary

Author: Abend, Sven, Allard, Baptiste, Alonso, Iván, Antoniadis, John, Araújo, Henrique, Arduini, Gianluigi, Arnold, Aidan S., Asano, Tobias, Augst, Nadja, Badurina, Leonardo, Balaz, Antun, Banks, Hannah, Barone, Michele, Barsanti, Michele, Bassi, Angelo, Battelier, Baptiste, Baynham, Charles F. A., Beaufils, Quentin, Belic, Aleksandar, Beniwal, Ankit, Bernabeu, Jose, Bertinelli, Francesco, Bertoldi, Andrea, Biswas, Ikbal Ahamed, Blas, Diego, Boegel, Patrick, Bogojevic, Aleksandar, Böhm, Jonas, Böhringer, Samuel, Bongs, Kai, Bouyer, Philippe, Brand, Christian, Brimis, Apostolos, Buchmueller, Oliver, Cacciapuoti, Luigi, Calatroni, Sergio, Canuel, Benjamin, Caprini, Chiara, Caramete, Ana, Caramete, Laurentiu, Carlesso, Matteo, Carlton, John, Casariego, Mateo, Charmandaris, Vassilis, Chen, Yu-Ao, Chiofalo, Maria Luisa, Cimbri, Alessia, Coleman, Jonathon, Constantin, Florin Lucian, Contaldi, Carlo R., Cui, Yanou, Ros, Elisa Da, Davies, Gavin, del Pino Rosendo, Esther, Deppner, Christian, Derevianko, Andrei, de Rham, Claudia, De Roeck, Albert, Derr, Daniel, Di Pumpo, Fabio, Djordjevic, Goran S., Döbrich, Babette, Domokos, Peter, Dornan, Peter, Doser, Michael, Drougakis, Giannis, Dunningham, Jacob, Duspayev, Alisher, Easo, Sajan, Eby, Joshua, Efremov, Maxim, Ekelöf, Tord, Elertas, Gedminas, Ellis, John, Evans, David, Fadeev, Pavel, Fani, Mattia, Fassi, Farida, Fattori, Marco, Fayet, Pierre, Felea, Daniel, Feng, Jie, Friedrich, Alexander, Fuchs, Elina, Gaaloul, Naceur, Gao, Dongfeng, Gardner, Susan, Garraway, Barry, Gauguet, Alexandre, Gerlach, Sandra, Gersemann, Matthias, Gibson, Valerie, Giese, Enno, Giudice, Gian F., Glasbrenner, Eric P., Gündogan, Mustafa, Haehnelt, Martin, Hakulinen, Timo, Hammerer, Klemens, Hanimeli, Ekim T., Harte, Tiffany, Hawkins, Leonie, Hees, Aurelien, Heise, Jaret, Henderson, Victoria A., Herrmann, Sven, Hird, Thomas M., Hogan, Jason M., Holst, Bodil, Holynski, Michael, Hussain, Kamran, Janson, Gregor, Jeglic, Peter, Jelezko, Fedor, Kagan, Michael, Kalliokoski, Matti, Kasevich, Mark, Kehagias, Alex, Kilian, Eva, Koley, Soumen, Konrad, Bernd, Kopp, Joachim, Kornakov, Georgy, Kovachy, Tim, Krutzik, Markus, Kumar, Mukesh, Kumar, Pradeep, Lämmerzahl, Claus, Landsberg, Greg, Langlois, Mehdi, Lanigan, Bryony, Lellouch, Samuel, Leone, Bruno, Poncin-Lafitte, Christophe Le, Lewicki, Marek, Leykauf, Bastian, Lezeik, Ali, Lombriser, Lucas, Luis Lopez-Gonzalez, J., Lopez Asamar, Elias, López Monjaraz, Cristian, Luciano, Giuseppe Gaetano, Mahmoud, M. A., Maleknejad, Azadeh, Marteau, Jacques, Massonnet, Didier, Mazumdar, Anupam, McCabe, Christopher, Meister, Matthias, Menu, Jonathan, Messineo, Giuseppe, Micalizio, Salvatore, Millington, Peter, Milosevic, Milan, Mitchell, Jeremiah, Montero, Mario, Morley, Gavin W., Müller, Jürgen, Müstecaploglu, Özgür E., Ni, Wei-Tou, Noller, Johannes, Odzak, Senad, Oi, Daniel K. L., Omar, Yasser, Pahl, Julia, Paling, Sean, Pandey, Saurabh, Pappas, George, Pareek, Vinay, Pasatembou, Elizabeth, Pelucchi, Emanuele, Pereira dos Santos, Franck, Piest, Baptist, Pikovski, Igor, Pilaftsis, Apostolos, Plunkett, Robert, Poggiani, Rosa, Prevedelli, Marco, Puputti, Julia, Veettil, Vishnupriya Puthiya, Quenby, John, Rafelski, Johann, Rajendran, Surjeet, Rasel, Ernst M., Sfar, Haifa Rejeb, Reynaud, Serge, Richaud, Andrea, Rodzinka, Tangui, Roura, Albert, Rudolph, Jan, Sabulsky, Dylan O., Safronova, Marianna S., Santamaria, Luigi, Schilling, Manuel, Schkolnik, Vladimir, Schleich, Wolfgang P., Schlippert, Dennis, Schneider, Ulrich, Schreck, Florian, Schubert, Christian, Schwersenz, Nico, Semakin, Aleksei, Sergijenko, Olga, Shao, Lijing, Shipsey, Ian, Singh, Rajeev, Smerzi, Augusto, Sopuerta, Carlos F., Spallicci, Alessandro D. A. M., Stefanescu, Petruta, Stergioulas, Nikolaos, Ströhle, Jannik, Struckmann, Christian, Tentindo, Silvia, Throssell, Henry, Tino, Guglielmo M., Tinsley, Jonathan N., Tintareanu Mircea, Ovidiu, Tkalcec, Kimberly, Tolley, Andrew J., Tornatore, Vincenza, Torres-Orjuela, Alejandro, Treutlein, Philipp, Trombettoni, Andrea, Tsai, Yu-Dai, Ufrecht, Christian, Ulmer, Stefan, Valuch, Daniel, Vaskonen, Ville, Vázquez-Aceves, Verónica, Vitanov, Nikolay V., Vogt, Christian, von Klitzing, Wolf, Vukics, András, Walser, Reinhold, Wang, Jin, Warburton, Niels, Webber-Date, Alexander, Wenzlawski, André, Werner, Michael, Williams, Jason, Windpassinger, Patrick, Wolf, Peter, Woerner, Lisa, Xuereb, André, Yahia, Mohamed E., Zambrini Cruzeiro, Emmanuel, Zarei, Moslem, Zhan, Mingsheng, Zhou, Lin, Zupan, Jure, Zupanic, Erik, Abend, Sven, Allard, Baptiste, Alonso, Iván, Antoniadis, John, Araújo, Henrique, Arduini, Gianluigi, Arnold, Aidan S., Asano, Tobias, Augst, Nadja, Badurina, Leonardo, Balaz, Antun, Banks, Hannah, Barone, Michele, Barsanti, Michele, Bassi, Angelo, Battelier, Baptiste, Baynham, Charles F. A., Beaufils, Quentin, Belic, Aleksandar, Beniwal, Ankit, Bernabeu, Jose, Bertinelli, Francesco, Bertoldi, Andrea, Biswas, Ikbal Ahamed, Blas, Diego, Boegel, Patrick, Bogojevic, Aleksandar, Böhm, Jonas, Böhringer, Samuel, Bongs, Kai, Bouyer, Philippe, Brand, Christian, Brimis, Apostolos, Buchmueller, Oliver, Cacciapuoti, Luigi, Calatroni, Sergio, Canuel, Benjamin, Caprini, Chiara, Caramete, Ana, Caramete, Laurentiu, Carlesso, Matteo, Carlton, John, Casariego, Mateo, Charmandaris, Vassilis, Chen, Yu-Ao, Chiofalo, Maria Luisa, Cimbri, Alessia, Coleman, Jonathon, Constantin, Florin Lucian, Contaldi, Carlo R., Cui, Yanou, Ros, Elisa Da, Davies, Gavin, del Pino Rosendo, Esther, Deppner, Christian, Derevianko, Andrei, de Rham, Claudia, De Roeck, Albert, Derr, Daniel, Di Pumpo, Fabio, Djordjevic, Goran S., Döbrich, Babette, Domokos, Peter, Dornan, Peter, Doser, Michael, Drougakis, Giannis, Dunningham, Jacob, Duspayev, Alisher, Easo, Sajan, Eby, Joshua, Efremov, Maxim, Ekelöf, Tord, Elertas, Gedminas, Ellis, John, Evans, David, Fadeev, Pavel, Fani, Mattia, Fassi, Farida, Fattori, Marco, Fayet, Pierre, Felea, Daniel, Feng, Jie, Friedrich, Alexander, Fuchs, Elina, Gaaloul, Naceur, Gao, Dongfeng, Gardner, Susan, Garraway, Barry, Gauguet, Alexandre, Gerlach, Sandra, Gersemann, Matthias, Gibson, Valerie, Giese, Enno, Giudice, Gian F., Glasbrenner, Eric P., Gündogan, Mustafa, Haehnelt, Martin, Hakulinen, Timo, Hammerer, Klemens, Hanimeli, Ekim T., Harte, Tiffany, Hawkins, Leonie, Hees, Aurelien, Heise, Jaret, Henderson, Victoria A., Herrmann, Sven, Hird, Thomas M., Hogan, Jason M., Holst, Bodil, Holynski, Michael, Hussain, Kamran, Janson, Gregor, Jeglic, Peter, Jelezko, Fedor, Kagan, Michael, Kalliokoski, Matti, Kasevich, Mark, Kehagias, Alex, Kilian, Eva, Koley, Soumen, Konrad, Bernd, Kopp, Joachim, Kornakov, Georgy, Kovachy, Tim, Krutzik, Markus, Kumar, Mukesh, Kumar, Pradeep, Lämmerzahl, Claus, Landsberg, Greg, Langlois, Mehdi, Lanigan, Bryony, Lellouch, Samuel, Leone, Bruno, Poncin-Lafitte, Christophe Le, Lewicki, Marek, Leykauf, Bastian, Lezeik, Ali, Lombriser, Lucas, Luis Lopez-Gonzalez, J., Lopez Asamar, Elias, López Monjaraz, Cristian, Luciano, Giuseppe Gaetano, Mahmoud, M. A., Maleknejad, Azadeh, Marteau, Jacques, Massonnet, Didier, Mazumdar, Anupam, McCabe, Christopher, Meister, Matthias, Menu, Jonathan, Messineo, Giuseppe, Micalizio, Salvatore, Millington, Peter, Milosevic, Milan, Mitchell, Jeremiah, Montero, Mario, Morley, Gavin W., Müller, Jürgen, Müstecaploglu, Özgür E., Ni, Wei-Tou, Noller, Johannes, Odzak, Senad, Oi, Daniel K. L., Omar, Yasser, Pahl, Julia, Paling, Sean, Pandey, Saurabh, Pappas, George, Pareek, Vinay, Pasatembou, Elizabeth, Pelucchi, Emanuele, Pereira dos Santos, Franck, Piest, Baptist, Pikovski, Igor, Pilaftsis, Apostolos, Plunkett, Robert, Poggiani, Rosa, Prevedelli, Marco, Puputti, Julia, Veettil, Vishnupriya Puthiya, Quenby, John, Rafelski, Johann, Rajendran, Surjeet, Rasel, Ernst M., Sfar, Haifa Rejeb, Reynaud, Serge, Richaud, Andrea, Rodzinka, Tangui, Roura, Albert, Rudolph, Jan, Sabulsky, Dylan O., Safronova, Marianna S., Santamaria, Luigi, Schilling, Manuel, Schkolnik, Vladimir, Schleich, Wolfgang P., Schlippert, Dennis, Schneider, Ulrich, Schreck, Florian, Schubert, Christian, Schwersenz, Nico, Semakin, Aleksei, Sergijenko, Olga, Shao, Lijing, Shipsey, Ian, Singh, Rajeev, Smerzi, Augusto, Sopuerta, Carlos F., Spallicci, Alessandro D. A. M., Stefanescu, Petruta, Stergioulas, Nikolaos, Ströhle, Jannik, Struckmann, Christian, Tentindo, Silvia, Throssell, Henry, Tino, Guglielmo M., Tinsley, Jonathan N., Tintareanu Mircea, Ovidiu, Tkalcec, Kimberly, Tolley, Andrew J., Tornatore, Vincenza, Torres-Orjuela, Alejandro, Treutlein, Philipp, Trombettoni, Andrea, Tsai, Yu-Dai, Ufrecht, Christian, Ulmer, Stefan, Valuch, Daniel, Vaskonen, Ville, Vázquez-Aceves, Verónica, Vitanov, Nikolay V., Vogt, Christian, von Klitzing, Wolf, Vukics, András, Walser, Reinhold, Wang, Jin, Warburton, Niels, Webber-Date, Alexander, Wenzlawski, André, Werner, Michael, Williams, Jason, Windpassinger, Patrick, Wolf, Peter, Woerner, Lisa, Xuereb, André, Yahia, Mohamed E., Zambrini Cruzeiro, Emmanuel, Zarei, Moslem, Zhan, Mingsheng, Zhou, Lin, Zupan, Jure, and Zupanic, Erik
Abstract: This document presents a summary of the 2023 Terrestrial Very-Long-Baseline Atom Interferometry Workshop hosted by CERN. The workshop brought together experts from around the world to discuss the exciting developments in large-scale atom interferometer (AI) prototypes and their potential for detecting ultralight dark matter and gravitational waves. The primary objective of the workshop was to lay the groundwork for an international TVLBAI proto-collaboration. This collaboration aims to unite researchers from different institutions to strategize and secure funding for terrestrial large-scale AI projects. The ultimate goal is to create a roadmap detailing the design and technology choices for one or more kilometer--scale detectors, which will be operational in the mid-2030s. The key sections of this report present the physics case and technical challenges, together with a comprehensive overview of the discussions at the workshop together with the main conclusions.
Published: 2024
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49. Writing the AI Father: a creative writer’s investigation into the challenges of portraying an Artificially Intelligent parent in children’s fiction

Author: Betts, Leone Annabella and Betts, Leone Annabella
Abstract: This research comprises two parts: a creative work in the form of a children’s novel, The Stickleback Hack, and a critical exegesis. Its focus is to investigate the value of incorporating academic theories into the matrix of influences through which characters are developed, and this is achieved through the practitioner-researcher’s endeavour to portray a nurturing but artificially intelligent (AI) parent and map the challenges therein. Originally conceived as Mom-E and later evolved into Dad-E, scholarly works are integrated iteratively with creative practice to scrutinise the influences behind the intuitive gendering of this character as female, and the motivation for transforming her to male. This results, in part, in the scholarly theories becoming influences themselves. First, the character’s earliest manifestation as Mom-E, a voice-only entity, is critically examined and positioned within wider understandings about how gender is ascribed onto talking computers. Next, in (re)imagining the character as Dad-E, gender tropes within paternal characters in children’s literature are identified, and their impact on creative decisions traced. Finally, the AI parent is interrogated through a posthuman lens, drawing on Donna Haraway’s (2016a) vision of the cyborg and other posthuman scholarship, including thinkers on children’s literature. Interconnected binaries including mind/body, individual/collective, nature/culture, and human/machine are used to consider and redraft elements of Dad-E and surrounding characters, in an effort to disrupt other rigid categorisations beyond gender. Throughout her commentary, the practitioner-researcher discusses the insights generated by her character-crafting labours, demonstrating how each of them contributes to knowledge. Novel and exegesis combined offer a unique expression of the complexities of portraying AI, which includes a conscious aspiration to circumnavigate harmful gender stereotyping and anthropocentric hubris. The critica
Published: 2024

50. Intravascular Ultrasound in the Detection of Bridging Stent Graft Instability During Fenestrated and Branched Endovascular Aneurysm Repair Procedures : A Multicentre Study on 274 Target Vessels

Author: Asciutto, Giuseppe, Ibrahim, Abdulhakim, Leone, Nicola, Gennai, Stefano, Piazza, Michele, Antonello, Michele, Wanhainen, Anders, Mani, Kevin, Lindström, David, Struk, Lisa, Oberhuber, Alexander, Asciutto, Giuseppe, Ibrahim, Abdulhakim, Leone, Nicola, Gennai, Stefano, Piazza, Michele, Antonello, Michele, Wanhainen, Anders, Mani, Kevin, Lindström, David, Struk, Lisa, and Oberhuber, Alexander
Abstract: OBJECTIVE: The use of intravascular ultrasound (IVUS) reduces contrast medium use and radiation exposure during conventional endovascular aneurysm repair (EVAR). The aim of this study was to evaluate the safety and efficacy of IVUS in detecting bridging stent graft (bSG) instability during fenestrated and branched EVAR (F/B-EVAR). METHODS: This was a prospective observational multicentre study. The following outcomes were evaluated: (1) technical success of the IVUS in each bSG, (2) IVUS findings compared with intra-operative angiography, (3) incidence of post-operative computed tomography angiography (CTA) findings not detected with IVUS, and (4) absence of IVUS related adverse events. Target visceral vessel (TVV) instability was defined as any branch or fenestration issues requiring an additional manoeuvre or re-intervention. Any IVUS assessment that detected stenosis, kinking, or any geometric TVV issue was considered to be branch instability. All procedures were performed in ad hoc hybrid rooms. RESULTS: Eighty patients (69% males; median age 72 years; interquartile range 59, 77 years) from four aortic centres treated with F/B-EVAR between January 2019 and September 2021 were included: 70 BEVAR (21 off the shelf; 49 custom made), eight FEVAR (custom made), and two F/B-EVAR (custom made), for a total of 300 potential TVVs. Two TVVs (0.7%) were left unstented and excluded from the analysis. The TVVs could not be accessed with the IVUS catheter in seven cases (2.3%). Furthermore, 17 (5.7%) TVVs could not be examined due to a malfunction of the IVUS catheter. The technical success of the IVUS assessment was 91.9% (274/298), with no IVUS related adverse events. Seven TVVs (2.5%) showed signs of bSG instability by means of IVUS, leading to immediate revisions. The first post-operative CTA at least 30 days after the index procedure was available in 268 of the 274 TVVs originally assessed by IVUS. In seven of the 268 TVVs (2.6%) a re-intervention became necessary due to
Published: 2024
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