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1. Mechanisms of Vascular Inflammation and Potential Therapeutic Targets: A Position Paper From the ESH Working Group on Small Arteries

Author: Rios, F, de Ciuceis, C, Georgiopoulos, G, Lazaridis, A, Nosalski, R, Pavlidis, G, Tual-Chalot, S, Agabiti-Rosei, C, Camargo, L, Dąbrowska, E, Quarti-Trevano, F, Hellmann, M, Masi, S, Lopreiato, M, Mavraganis, G, Mengozzi, A, Montezano, A, Stavropoulos, K, Winklewski, P, Wolf, J, Costantino, S, Doumas, M, Gkaliagkousi, E, Grassi, G, Guzik, T, Ikonomidis, I, Narkiewicz, K, Paneni, F, Rizzoni, D, Stamatelopoulos, K, Stellos, K, Taddei, S, Touyz, R, Virdis, A, Rios, Francisco J., de Ciuceis, Carolina, Georgiopoulos, Georgios, Lazaridis, Antonios, Nosalski, Ryszard, Pavlidis, George, Tual-Chalot, Simon, Agabiti-Rosei, Claudia, Camargo, Livia L., Dąbrowska, Edyta, Quarti-Trevano, Fosca, Hellmann, Marcin, Masi, Stefano, Lopreiato, Mariarosaria, Mavraganis, Georgios, Mengozzi, Alessandro, Montezano, Augusto C., Stavropoulos, Konstantinos, Winklewski, Pawel J., Wolf, Jacek, Costantino, Sarah, Doumas, Michael, Gkaliagkousi, Eugenia, Grassi, Guido, Guzik, Tomasz J., Ikonomidis, Ignatios, Narkiewicz, Krzysztof, Paneni, Francesco, Rizzoni, Damiano, Stamatelopoulos, Kimon, Stellos, Konstantinos, Taddei, Stefano, Touyz, Rhian M, Virdis, Agostino, Rios, F, de Ciuceis, C, Georgiopoulos, G, Lazaridis, A, Nosalski, R, Pavlidis, G, Tual-Chalot, S, Agabiti-Rosei, C, Camargo, L, Dąbrowska, E, Quarti-Trevano, F, Hellmann, M, Masi, S, Lopreiato, M, Mavraganis, G, Mengozzi, A, Montezano, A, Stavropoulos, K, Winklewski, P, Wolf, J, Costantino, S, Doumas, M, Gkaliagkousi, E, Grassi, G, Guzik, T, Ikonomidis, I, Narkiewicz, K, Paneni, F, Rizzoni, D, Stamatelopoulos, K, Stellos, K, Taddei, S, Touyz, R, Virdis, A, Rios, Francisco J., de Ciuceis, Carolina, Georgiopoulos, Georgios, Lazaridis, Antonios, Nosalski, Ryszard, Pavlidis, George, Tual-Chalot, Simon, Agabiti-Rosei, Claudia, Camargo, Livia L., Dąbrowska, Edyta, Quarti-Trevano, Fosca, Hellmann, Marcin, Masi, Stefano, Lopreiato, Mariarosaria, Mavraganis, Georgios, Mengozzi, Alessandro, Montezano, Augusto C., Stavropoulos, Konstantinos, Winklewski, Pawel J., Wolf, Jacek, Costantino, Sarah, Doumas, Michael, Gkaliagkousi, Eugenia, Grassi, Guido, Guzik, Tomasz J., Ikonomidis, Ignatios, Narkiewicz, Krzysztof, Paneni, Francesco, Rizzoni, Damiano, Stamatelopoulos, Kimon, Stellos, Konstantinos, Taddei, Stefano, Touyz, Rhian M, and Virdis, Agostino
Abstract: Inflammatory responses in small vessels play an important role in the development of cardiovascular diseases, including hypertension, stroke, and small vessel disease. This involves various complex molecular processes including oxidative stress, inflammasome activation, immune-mediated responses, and protein misfolding, which together contribute to microvascular damage. In addition, epigenetic factors, including DNA methylation, histone modifications, and microRNAs influence vascular inflammation and injury. These phenomena may be acquired during the aging process or due to environmental factors. Activation of proinflammatory signaling pathways and molecular events induce low-grade and chronic inflammation with consequent cardiovascular damage. Identifying mechanism-specific targets might provide opportunities in the development of novel therapeutic approaches. Monoclonal antibodies targeting inflammatory cytokines and epigenetic drugs, show promise in reducing microvascular inflammation and associated cardiovascular diseases. In this article, we provide a comprehensive discussion of the complex mechanisms underlying microvascular inflammation and offer insights into innovative therapeutic strategies that may ameliorate vascular injury in cardiovascular disease.
Published: 2024

2. The importance of microvascular inflammation in ageing and age-related diseases: a position paper from the ESH working group on small arteries, section of microvascular inflammation

Author: Mengozzi, A, de Ciuceis, C, Dell'Oro, R, Georgiopoulos, G, Lazaridis, A, Nosalski, R, Pavlidis, G, Tual-Chalot, S, Agabiti-Rosei, C, Anyfanti, P, Camargo, L, Dąbrowska, E, Quarti-Trevano, F, Hellmann, M, Masi, S, Mavraganis, G, Montezano, A, Rios, F, Winklewski, P, Wolf, J, Costantino, S, Gkaliagkousi, E, Grassi, G, Guzik, T, Ikonomidis, I, Narkiewicz, K, Paneni, F, Rizzoni, D, Stamatelopoulos, K, Stellos, K, Taddei, S, Touyz, R, Triantafyllou, A, Virdis, A, Mengozzi, Alessandro, de Ciuceis, Carolina, Dell'oro, Raffaella, Georgiopoulos, Georgios, Lazaridis, Antonios, Nosalski, Ryszard, Pavlidis, George, Tual-Chalot, Simon, Agabiti-Rosei, Claudia, Anyfanti, Panagiota, Camargo, Livia L, Dąbrowska, Edyta, Quarti-Trevano, Fosca, Hellmann, Marcin, Masi, Stefano, Mavraganis, Georgios, Montezano, Augusto C, Rios, Francesco J, Winklewski, Pawel J, Wolf, Jacek, Costantino, Sarah, Gkaliagkousi, Eugenia, Grassi, Guido, Guzik, Tomasz J, Ikonomidis, Ignatios, Narkiewicz, Krzysztof, Paneni, Francesco, Rizzoni, Damiano, Stamatelopoulos, Kimon, Stellos, Konstantinos, Taddei, Stefano, Touyz, Rhian M, Triantafyllou, Areti, Virdis, Agostino, Mengozzi, A, de Ciuceis, C, Dell'Oro, R, Georgiopoulos, G, Lazaridis, A, Nosalski, R, Pavlidis, G, Tual-Chalot, S, Agabiti-Rosei, C, Anyfanti, P, Camargo, L, Dąbrowska, E, Quarti-Trevano, F, Hellmann, M, Masi, S, Mavraganis, G, Montezano, A, Rios, F, Winklewski, P, Wolf, J, Costantino, S, Gkaliagkousi, E, Grassi, G, Guzik, T, Ikonomidis, I, Narkiewicz, K, Paneni, F, Rizzoni, D, Stamatelopoulos, K, Stellos, K, Taddei, S, Touyz, R, Triantafyllou, A, Virdis, A, Mengozzi, Alessandro, de Ciuceis, Carolina, Dell'oro, Raffaella, Georgiopoulos, Georgios, Lazaridis, Antonios, Nosalski, Ryszard, Pavlidis, George, Tual-Chalot, Simon, Agabiti-Rosei, Claudia, Anyfanti, Panagiota, Camargo, Livia L, Dąbrowska, Edyta, Quarti-Trevano, Fosca, Hellmann, Marcin, Masi, Stefano, Mavraganis, Georgios, Montezano, Augusto C, Rios, Francesco J, Winklewski, Pawel J, Wolf, Jacek, Costantino, Sarah, Gkaliagkousi, Eugenia, Grassi, Guido, Guzik, Tomasz J, Ikonomidis, Ignatios, Narkiewicz, Krzysztof, Paneni, Francesco, Rizzoni, Damiano, Stamatelopoulos, Kimon, Stellos, Konstantinos, Taddei, Stefano, Touyz, Rhian M, Triantafyllou, Areti, and Virdis, Agostino
Abstract: Microcirculation is pervasive and orchestrates a profound regulatory cross-talk with the surrounding tissue and organs. Similarly, it is one of the earliest biological systems targeted by environmental stressors and consequently involved in the development and progression of ageing and age-related disease. Microvascular dysfunction, if not targeted, leads to a steady derangement of the phenotype, which cumulates comorbidities and eventually results in a nonrescuable, very high-cardiovascular risk. Along the broad spectrum of pathologies, both shared and distinct molecular pathways and pathophysiological alteration are involved in the disruption of microvascular homeostasis, all pointing to microvascular inflammation as the putative primary culprit. This position paper explores the presence and the detrimental contribution of microvascular inflammation across the whole spectrum of chronic age-related diseases, which characterise the 21st-century healthcare landscape. The manuscript aims to strongly affirm the centrality of microvascular inflammation by recapitulating the current evidence and providing a clear synoptic view of the whole cardiometabolic derangement. Indeed, there is an urgent need for further mechanistic exploration to identify clear, very early or disease-specific molecular targets to provide an effective therapeutic strategy against the otherwise unstoppable rising prevalence of age-related diseases.
Published: 2023

3. Corrigendum to: “An international genome-wide meta-analysis of primary biliary cholangitis: Novel risk loci and candidate drugs” [J Hepatol 75 (2021) 572-581, (S0168827821003342), (10.1016/j.jhep.2021.04.055)]

Author: Cordell H. J., Cordell, H, Fryett, J, Ueno, K, Darlay, R, Aiba, Y, Hitomi, Y, Kawashima, M, Nishida, N, Khor, S, Gervais, O, Kawai, Y, Nagasaki, M, Tokunaga, K, Tang, R, Shi, Y, Li, Z, Juran, B, Atkinson, E, Gerussi, A, Carbone, M, Asselta, R, Cheung, A, de Andrade, M, Baras, A, Horowitz, J, Ferreira, M, Sun, D, Jones, D, Flack, S, Spicer, A, Mulcahy, V, Byan, J, Han, Y, Sandford, R, Lazaridis, K, Amos, C, Hirschfield, G, Seldin, M, Invernizzi, P, Siminovitch, K, Ma, X, Nakamura, M, Mells, G, Cordell H. J., Fryett J. J., Ueno K., Darlay R., Aiba Y., Hitomi Y., Kawashima M., Nishida N., Khor S. -S., Gervais O., Kawai Y., Nagasaki M., Tokunaga K., Tang R., Shi Y., Li Z., Juran B. D., Atkinson E. J., Gerussi A., Carbone M., Asselta R., Cheung A., de Andrade M., Baras A., Horowitz J., Ferreira M. A. R., Sun D., Jones D. E., Flack S., Spicer A., Mulcahy V. L., Byan J., Han Y., Sandford R. N., Lazaridis K. N., Amos C. I., Hirschfield G. M., Seldin M. F., Invernizzi P., Siminovitch K. A., Ma X., Nakamura M., Mells G. F., Cordell H. J., Cordell, H, Fryett, J, Ueno, K, Darlay, R, Aiba, Y, Hitomi, Y, Kawashima, M, Nishida, N, Khor, S, Gervais, O, Kawai, Y, Nagasaki, M, Tokunaga, K, Tang, R, Shi, Y, Li, Z, Juran, B, Atkinson, E, Gerussi, A, Carbone, M, Asselta, R, Cheung, A, de Andrade, M, Baras, A, Horowitz, J, Ferreira, M, Sun, D, Jones, D, Flack, S, Spicer, A, Mulcahy, V, Byan, J, Han, Y, Sandford, R, Lazaridis, K, Amos, C, Hirschfield, G, Seldin, M, Invernizzi, P, Siminovitch, K, Ma, X, Nakamura, M, Mells, G, Cordell H. J., Fryett J. J., Ueno K., Darlay R., Aiba Y., Hitomi Y., Kawashima M., Nishida N., Khor S. -S., Gervais O., Kawai Y., Nagasaki M., Tokunaga K., Tang R., Shi Y., Li Z., Juran B. D., Atkinson E. J., Gerussi A., Carbone M., Asselta R., Cheung A., de Andrade M., Baras A., Horowitz J., Ferreira M. A. R., Sun D., Jones D. E., Flack S., Spicer A., Mulcahy V. L., Byan J., Han Y., Sandford R. N., Lazaridis K. N., Amos C. I., Hirschfield G. M., Seldin M. F., Invernizzi P., Siminovitch K. A., Ma X., Nakamura M., and Mells G. F.
Abstract: It has come to our attention that while we explained that data for the control group in our study was provided by Understanding Society, we did not include the required statement for use of these data, which is the following: “Understanding Society: The UK Household Longitudinal Study is led by the Institute for Social and Economic Research at the University of Essex and funded by the Economic and Social Research Council. The survey was conducted by NatCen and the genome-wide scan data were analysed and deposited by the Wellcome Trust Sanger Institute. Information on how to access the data can be found on the Understanding Society website https://www.understandingsociety.ac.uk/.” We apologise for any inconvenience caused.
Published: 2023

4. Two years later: Is the SARS-CoV-2 pandemic still having an impact on emergency surgery? An international cross-sectional survey among WSES members

Author: Reichert, M, Sartelli, M, Weigand, M, Hecker, M, Oppelt, P, Noll, J, Askevold, I, Liese, J, Padberg, W, Coccolini, F, Catena, F, Hecker, A, Peckham-Cooper, A, Camacho-Ortiz, A, Mastoraki, A, Landaluce-Olavarria, A, Pal, A, Kuriyama, A, Chichom-Mefire, A, Porcu, A, Martinez-Perez, A, Karamarkovic, A, Osipov, A, Coppola, A, Cucchetti, A, Spolini, A, Giordano, A, Reinisch-Liese, A, Kavalakat, A, Vasilescu, A, Alamin, A, Gupta, A, Dascalu, A, Musina, A, Bakopoulos, A, Zakaria, A, Vereczkei, A, Balla, A, Bottari, A, Baumann, A, Fette, A, Litvin, A, Reichert, A, Guariniello, A, Paspala, A, Schneck, A, Brillantino, A, Pesce, A, Isik, A, Leppaniemi, A, Papadopoulos, A, Kechagias, A, Mohamed, A, Mitul, A, Marinis, A, Syllaios, A, Mantoglu, B, De Simone, B, Weiss, B, Posentrup, B, Picardi, B, Zampogna, B, Sakakushev, B, Atanasov, B, Nardo, B, Calik, B, Cremonini, C, Ordonez, C, Seretis, C, Cascone, C, Chouliaras, C, Bendinelli, C, Lopes, C, Guerci, C, Weber, C, Nastos, C, Mesina, C, Caputo, D, Massalou, D, Cavaliere, D, Mcnamara, D, Demetriades, D, Pantalone, D, Coletta, D, Sasia, D, Visconti, D, Weber, D, Corallino, D, Chatzipetris, D, Manatakis, D, Ntourakis, D, Papaconstantinou, D, Schizas, D, Chrysikos, D, Adamovich, D, Elkafrawy, D, Seban, D, Garcia, E, Baldini, E, Picetti, E, Tan, E, Baili, E, Lostoridis, E, Toma, E, Colak, E, Cerutti, E, Steyn, E, Hsabo, E, Kapetanakis, E, Kaouras, E, Schneck, E, Akin, E, Gonullu, E, Celik, E, Cicuttin, E, Pinotti, E, Johnsson, E, Moore, E, Agastra, E, Dimitrov, E, Griffiths, E, D'Acapito, F, Saraceno, F, Alconchel, F, Zeppernick, F, Rodriguez, F, Abu-Zidan, F, Pecchini, F, Favi, F, Ferrara, F, Fleres, F, Pata, F, Roscio, F, Mulita, F, Dor, F, Linder, F, Dimofte, G, Rodrigues, G, Nita, G, Sganga, G, Martines, G, Mazzarella, G, Perrone, G, Velmahos, G, Lianos, G, Tomadze, G, Baiocchi, G, D'Ambrosio, G, Pellino, G, Pattacini, G, Giraudo, G, Lisi, G, Tebala, G, Pirozzolo, G, Montori, G, Argenio, G, Brisinda, G, Curro, G, Giuliani, G, Palomba, G, Roscitano, G, Avsar, G, Augustin, G, Clarizia, G, Vega, G, Fraga, G, Sethi, H, Eltyeb, H, Lohse, H, Bayhan, H, Hamid, H, Kryvoruchko, I, Iannone, I, Wani, I, Lazaridis, I, Katsaros, I, Nikolopoulos, I, Negoi, I, Reccia, I, Di Carlo, I, Olaoye, I, Czepiel, J, Kim, J, Meyer, J, Terrazas, J, Tochie, J, Galante, J, Davies, J, Sugand, K, Gonfa, K, Rasa, K, Kok, K, Apostolou, K, Lasithiotakis, K, Tsekouras, K, Angamuthu, K, Akhmeteli, L, Sydorchuk, L, Fortuna, L, Siragusa, L, Pagani, L, Solaini, L, Miller, L, Bains, L, Ansaloni, L, Ferrario, L, Bonavina, L, Conti, L, Buonomo, L, Tallon-Aguilar, L, Tomczyk, L, Widmer, L, Waledziak, M, Gachabayov, M, Bulanauca, M, Malbrain, M, Maegele, M, Catarci, M, Ceresoli, M, Ranucci, M, Antonopoulou, M, Papadoliopoulou, M, Valenti, M, Sotiropoulou, M, D'Oria, M, Martin, M, Hirschburger, M, Veroux, M, Fantoni, M, Nardi, M, Tolonen, M, Montuori, M, Podda, M, Scheiterle, M, Frountzas, M, Sarikaya, M, Yildirim, M, Bender, M, Vailas, M, Teuben, M, Campanelli, M, Ammendola, M, Malerba, M, Pisano, M, Pertea, M, Slavchev, M, Ukkonen, M, Bala, M, Chirica, M, Barone, M, Shaat, M, Mohammed, M, Abuelgasim, M, Gureh, M, Ouadii, M, Balkan, M, Mohamed, M, Hakseven, M, Velenciuc, N, Cillara, N, De'Angelis, N, Tamini, N, Zavras, N, Machairas, N, Michalopoulos, N, Koliakos, N, Pararas, N, Donlon, N, Medappil, N, Ben-Ishay, O, Stefano, O, Islam, O, Tammo, O, Ioannidis, O, Aparicio, O, Baraket, O, Kumar, P, Cianci, P, Ortenwall, P, Uchikov, P, de Reuver, P, Stahel, P, Barie, P, Piccoli, M, Major, P, Navsaria, P, Sasmal, P, Coimbra, R, Rahim, R, Capoglu, R, Koshy, R, Gonsaga, R, Pertile, R, Mohamed, R, Deryol, R, Sawyer, R, Angelico, R, Ragozzino, R, Bini, R, Cammarata, R, Scaramuzzo, R, Gioco, R, Sydorchuk, R, Ahmed, S, Di Saverio, S, Emile, S, Delibegovic, S, Marwah, S, Symeonidis, S, Thomas, S, Demir, S, Awad, S, Atici, S, Chooklin, S, Meric, S, Sarikaya, S, Chowdhury, S, Mirghani, S, Wren, S, Gargarella, S, Del Monte, S, Esposito, S, Xenaki, S, Mohamed, S, Beka, S, Lunca, S, Delis, S, Dritsas, S, Morarasu, S, Magnone, S, Rossi, S, Bitsianis, S, Kykalos, S, Baral, S, Jain, S, Ali, S, Pintar, T, Triantafyllou, T, Delko, T, Perra, T, Sidiropoulos, T, Scalea, T, Vilz, T, Hardcastle, T, Wannatoop, T, Herzog, T, Mishra, T, Boggi, U, Calu, V, Tomajer, V, Agnoletti, V, Lohsiriwat, V, Kong, V, Munoz-Cruzado, V, Shelat, V, Khokha, V, Ghannam, W, Biffl, W, Zuidema, W, Kara, Y, Kobe, Y, Demetrashvili, Z, Memish, Z, Madrazo, Z, Balogh, Z, Bayhan, Z, Reichert M., Sartelli M., Weigand M. A., Hecker M., Oppelt P. U., Noll J., Askevold I. H., Liese J., Padberg W., Coccolini F., Catena F., Hecker A., Peckham-Cooper A., Camacho-Ortiz A., Mastoraki A. T., Landaluce-Olavarria A., Pal A. K., Kuriyama A., Chichom-Mefire A., Porcu A., Martinez-Perez A., Karamarkovic A. R., Osipov A. V., Coppola A., Cucchetti A., Spolini A., Giordano A., Reinisch-Liese A., Kavalakat A. J., Vasilescu A., Alamin A., Gupta A., Dascalu A. M., Musina A. -M., Bakopoulos A., Zakaria A. D., Vereczkei A., Balla A., Bottari A., Baumann A., Fette A., Litvin A., Reichert A. K., Guariniello A., Paspala A., Schneck A. -S., Brillantino A., Pesce A., Isik A., Leppaniemi A. K., Papadopoulos A., Kechagias A., Mohamed A. Y. A., Mitul A. R., Marinis A., Syllaios A., Mantoglu B., De Simone B., Weiss B. S., Posentrup B., Picardi B., Zampogna B., Sakakushev B. E., Atanasov B. C., Nardo B., Calik B., Cremonini C., Ordonez C. A., Seretis C., Cascone C., Chouliaras C., Bendinelli C., Lopes C., Guerci C., Weber C., Nastos C., Mesina C., Caputo D., Massalou D., Cavaliere D., McNamara D. A., Demetriades D., Pantalone D., Coletta D., Sasia D., Visconti D., Weber D. G., Corallino D., Chatzipetris D., Manatakis D. K., Ntourakis D., Papaconstantinou D., Schizas D., Chrysikos D., Adamovich D. M., Elkafrawy D., Seban D., Garcia E. F. H., Baldini E., Picetti E., Tan E. C. T. H., Baili E., Lostoridis E., Toma E. A., Colak E., Cerutti E., Steyn E., Hsabo E. A., Kapetanakis E. I., Kaouras E., Schneck E., Akin E., Gonullu E., celik E., Cicuttin E., Pinotti E., Johnsson E., Moore E. E., Agastra E., Dimitrov E. N., Griffiths E. A., D'Acapito F., Saraceno F., Alconchel F., Zeppernick F. A., Rodriguez F. M., Abu-Zidan F., Pecchini F., Favi F., Ferrara F., Fleres F., Pata F., Roscio F. P. M., Mulita F., Dor F. J. M. F., Linder F., Dimofte G., Rodrigues G., Nita G., Sganga G., Martines G., Mazzarella G., Perrone G., Velmahos G., Lianos G. D., Tomadze G., Baiocchi G. L., D'Ambrosio G., Pellino G., Pattacini G. C., Giraudo G., Lisi G., Tebala G. D., Pirozzolo G., Montori G., Argenio G., Brisinda G., Curro G., Giuliani G., Palomba G., Roscitano G., Avsar G., Augustin G., Clarizia G., Vega G. M. M., Fraga G. P., Sethi H., Eltyeb H. A., Lohse H. A. S., Lohse H. R. S., Bayhan H., Hamid H. K. S., Kryvoruchko I. A., Iannone I., Wani I., Lazaridis I. I., Katsaros I., Nikolopoulos I., Negoi I., Reccia I., Di Carlo I., Olaoye I. O., Czepiel J., Kim J. I., Meyer J., Terrazas J. M. S., Tochie J. N., Galante J. M., Davies J., Sugand K., Gonfa K. B., Rasa K., Kok K. Y. Y., Apostolou K. G., Lasithiotakis K., Tsekouras K., Angamuthu K., Akhmeteli L., Sydorchuk L., Fortuna L., Siragusa L., Pagani L., Solaini L., Miller L. A., Bains L., Ansaloni L., Ferrario L., Bonavina L., Conti L., Buonomo L. A., Tallon-Aguilar L., Tomczyk L., Widmer L. W., Waledziak M., Gachabayov M., Bulanauca M. M., Malbrain M. L. N. G., Maegele M., Catarci M., Ceresoli M., Ranucci M. C., Antonopoulou M. I., Papadoliopoulou M., Valenti M. R., Sotiropoulou M., D'Oria M., Martin M. S., Hirschburger M., Veroux M., Fantoni M., Nardi M., Tolonen M., Montuori M., Podda M., Scheiterle M., Frountzas M., Sarikaya M., Yildirim M., Bender M., Vailas M., Teuben M., Campanelli M., Ammendola M., Malerba M., Pisano M., Pertea M., Slavchev M., Ukkonen M., Bala M., Chirica M., Barone M., Shaat M. M., Mohammed M. J. S., Abuelgasim M. A. A., Gureh M., Ouadii M., Balkan M., Mohamed M., Hakseven M., Velenciuc N., Cillara N., de'Angelis N., Tamini N., Zavras N. J., Machairas N., Michalopoulos N., Koliakos N. N., Pararas N., Donlon N. E., Medappil N., Ben-Ishay O., Stefano O., Islam O., Tammo O., Ioannidis O., Aparicio O., Baraket O., Kumar P., Cianci P., Ortenwall P., Uchikov P. A., de Reuver P., Stahel P. F., Barie P. S., Piccoli M., Major P., Navsaria P. H., Sasmal P. K., Coimbra R., Rahim R., Capoglu R., Koshy R. M., Gonsaga R. A. T., Pertile R., Mohamed R. R. M., Deryol R., Sawyer R. G., Angelico R., Ragozzino R., Bini R., Cammarata R., Scaramuzzo R., Gioco R., Sydorchuk R., Ahmed S., Di Saverio S., Emile S. H., Delibegovic S., Marwah S., Symeonidis S., Thomas S. G., Demir S., Awad S. S., Atici S. D., Chooklin S., Meric S., Sarikaya S., Chowdhury S., Mirghani S. F., Wren S. M., Gargarella S., Del Monte S. R., Esposito S., Xenaki S., Mohamed S. F. G., Beka S. G., Lunca S., Delis S. G., Dritsas S., Morarasu S., Magnone S., Rossi S., Bitsianis S., Kykalos S., Baral S., Jain S. A., Ali S. M., Pintar T., Triantafyllou T., Delko T., Perra T., Sidiropoulos T. A., Scalea T. M., Vilz T. O., Hardcastle T. C., Wannatoop T., Herzog T., Mishra T. S., Boggi U., Calu V., Tomajer V., Agnoletti V., Lohsiriwat V., Kong V., Munoz-Cruzado V. D., Shelat V. G., Khokha V., Ghannam W. M., Biffl W. L., Zuidema W., Kara Y., Kobe Y., Demetrashvili Z., Memish Z. A., Madrazo Z., Balogh Z. J., Bayhan Z., Reichert, M, Sartelli, M, Weigand, M, Hecker, M, Oppelt, P, Noll, J, Askevold, I, Liese, J, Padberg, W, Coccolini, F, Catena, F, Hecker, A, Peckham-Cooper, A, Camacho-Ortiz, A, Mastoraki, A, Landaluce-Olavarria, A, Pal, A, Kuriyama, A, Chichom-Mefire, A, Porcu, A, Martinez-Perez, A, Karamarkovic, A, Osipov, A, Coppola, A, Cucchetti, A, Spolini, A, Giordano, A, Reinisch-Liese, A, Kavalakat, A, Vasilescu, A, Alamin, A, Gupta, A, Dascalu, A, Musina, A, Bakopoulos, A, Zakaria, A, Vereczkei, A, Balla, A, Bottari, A, Baumann, A, Fette, A, Litvin, A, Reichert, A, Guariniello, A, Paspala, A, Schneck, A, Brillantino, A, Pesce, A, Isik, A, Leppaniemi, A, Papadopoulos, A, Kechagias, A, Mohamed, A, Mitul, A, Marinis, A, Syllaios, A, Mantoglu, B, De Simone, B, Weiss, B, Posentrup, B, Picardi, B, Zampogna, B, Sakakushev, B, Atanasov, B, Nardo, B, Calik, B, Cremonini, C, Ordonez, C, Seretis, C, Cascone, C, Chouliaras, C, Bendinelli, C, Lopes, C, Guerci, C, Weber, C, Nastos, C, Mesina, C, Caputo, D, Massalou, D, Cavaliere, D, Mcnamara, D, Demetriades, D, Pantalone, D, Coletta, D, Sasia, D, Visconti, D, Weber, D, Corallino, D, Chatzipetris, D, Manatakis, D, Ntourakis, D, Papaconstantinou, D, Schizas, D, Chrysikos, D, Adamovich, D, Elkafrawy, D, Seban, D, Garcia, E, Baldini, E, Picetti, E, Tan, E, Baili, E, Lostoridis, E, Toma, E, Colak, E, Cerutti, E, Steyn, E, Hsabo, E, Kapetanakis, E, Kaouras, E, Schneck, E, Akin, E, Gonullu, E, Celik, E, Cicuttin, E, Pinotti, E, Johnsson, E, Moore, E, Agastra, E, Dimitrov, E, Griffiths, E, D'Acapito, F, Saraceno, F, Alconchel, F, Zeppernick, F, Rodriguez, F, Abu-Zidan, F, Pecchini, F, Favi, F, Ferrara, F, Fleres, F, Pata, F, Roscio, F, Mulita, F, Dor, F, Linder, F, Dimofte, G, Rodrigues, G, Nita, G, Sganga, G, Martines, G, Mazzarella, G, Perrone, G, Velmahos, G, Lianos, G, Tomadze, G, Baiocchi, G, D'Ambrosio, G, Pellino, G, Pattacini, G, Giraudo, G, Lisi, G, Tebala, G, Pirozzolo, G, Montori, G, Argenio, G, Brisinda, G, Curro, G, Giuliani, G, Palomba, G, Roscitano, G, Avsar, G, Augustin, G, Clarizia, G, Vega, G, Fraga, G, Sethi, H, Eltyeb, H, Lohse, H, Bayhan, H, Hamid, H, Kryvoruchko, I, Iannone, I, Wani, I, Lazaridis, I, Katsaros, I, Nikolopoulos, I, Negoi, I, Reccia, I, Di Carlo, I, Olaoye, I, Czepiel, J, Kim, J, Meyer, J, Terrazas, J, Tochie, J, Galante, J, Davies, J, Sugand, K, Gonfa, K, Rasa, K, Kok, K, Apostolou, K, Lasithiotakis, K, Tsekouras, K, Angamuthu, K, Akhmeteli, L, Sydorchuk, L, Fortuna, L, Siragusa, L, Pagani, L, Solaini, L, Miller, L, Bains, L, Ansaloni, L, Ferrario, L, Bonavina, L, Conti, L, Buonomo, L, Tallon-Aguilar, L, Tomczyk, L, Widmer, L, Waledziak, M, Gachabayov, M, Bulanauca, M, Malbrain, M, Maegele, M, Catarci, M, Ceresoli, M, Ranucci, M, Antonopoulou, M, Papadoliopoulou, M, Valenti, M, Sotiropoulou, M, D'Oria, M, Martin, M, Hirschburger, M, Veroux, M, Fantoni, M, Nardi, M, Tolonen, M, Montuori, M, Podda, M, Scheiterle, M, Frountzas, M, Sarikaya, M, Yildirim, M, Bender, M, Vailas, M, Teuben, M, Campanelli, M, Ammendola, M, Malerba, M, Pisano, M, Pertea, M, Slavchev, M, Ukkonen, M, Bala, M, Chirica, M, Barone, M, Shaat, M, Mohammed, M, Abuelgasim, M, Gureh, M, Ouadii, M, Balkan, M, Mohamed, M, Hakseven, M, Velenciuc, N, Cillara, N, De'Angelis, N, Tamini, N, Zavras, N, Machairas, N, Michalopoulos, N, Koliakos, N, Pararas, N, Donlon, N, Medappil, N, Ben-Ishay, O, Stefano, O, Islam, O, Tammo, O, Ioannidis, O, Aparicio, O, Baraket, O, Kumar, P, Cianci, P, Ortenwall, P, Uchikov, P, de Reuver, P, Stahel, P, Barie, P, Piccoli, M, Major, P, Navsaria, P, Sasmal, P, Coimbra, R, Rahim, R, Capoglu, R, Koshy, R, Gonsaga, R, Pertile, R, Mohamed, R, Deryol, R, Sawyer, R, Angelico, R, Ragozzino, R, Bini, R, Cammarata, R, Scaramuzzo, R, Gioco, R, Sydorchuk, R, Ahmed, S, Di Saverio, S, Emile, S, Delibegovic, S, Marwah, S, Symeonidis, S, Thomas, S, Demir, S, Awad, S, Atici, S, Chooklin, S, Meric, S, Sarikaya, S, Chowdhury, S, Mirghani, S, Wren, S, Gargarella, S, Del Monte, S, Esposito, S, Xenaki, S, Mohamed, S, Beka, S, Lunca, S, Delis, S, Dritsas, S, Morarasu, S, Magnone, S, Rossi, S, Bitsianis, S, Kykalos, S, Baral, S, Jain, S, Ali, S, Pintar, T, Triantafyllou, T, Delko, T, Perra, T, Sidiropoulos, T, Scalea, T, Vilz, T, Hardcastle, T, Wannatoop, T, Herzog, T, Mishra, T, Boggi, U, Calu, V, Tomajer, V, Agnoletti, V, Lohsiriwat, V, Kong, V, Munoz-Cruzado, V, Shelat, V, Khokha, V, Ghannam, W, Biffl, W, Zuidema, W, Kara, Y, Kobe, Y, Demetrashvili, Z, Memish, Z, Madrazo, Z, Balogh, Z, Bayhan, Z, Reichert M., Sartelli M., Weigand M. A., Hecker M., Oppelt P. U., Noll J., Askevold I. H., Liese J., Padberg W., Coccolini F., Catena F., Hecker A., Peckham-Cooper A., Camacho-Ortiz A., Mastoraki A. T., Landaluce-Olavarria A., Pal A. K., Kuriyama A., Chichom-Mefire A., Porcu A., Martinez-Perez A., Karamarkovic A. R., Osipov A. V., Coppola A., Cucchetti A., Spolini A., Giordano A., Reinisch-Liese A., Kavalakat A. J., Vasilescu A., Alamin A., Gupta A., Dascalu A. M., Musina A. -M., Bakopoulos A., Zakaria A. D., Vereczkei A., Balla A., Bottari A., Baumann A., Fette A., Litvin A., Reichert A. K., Guariniello A., Paspala A., Schneck A. -S., Brillantino A., Pesce A., Isik A., Leppaniemi A. K., Papadopoulos A., Kechagias A., Mohamed A. Y. A., Mitul A. R., Marinis A., Syllaios A., Mantoglu B., De Simone B., Weiss B. S., Posentrup B., Picardi B., Zampogna B., Sakakushev B. E., Atanasov B. C., Nardo B., Calik B., Cremonini C., Ordonez C. A., Seretis C., Cascone C., Chouliaras C., Bendinelli C., Lopes C., Guerci C., Weber C., Nastos C., Mesina C., Caputo D., Massalou D., Cavaliere D., McNamara D. A., Demetriades D., Pantalone D., Coletta D., Sasia D., Visconti D., Weber D. G., Corallino D., Chatzipetris D., Manatakis D. K., Ntourakis D., Papaconstantinou D., Schizas D., Chrysikos D., Adamovich D. M., Elkafrawy D., Seban D., Garcia E. F. H., Baldini E., Picetti E., Tan E. C. T. H., Baili E., Lostoridis E., Toma E. A., Colak E., Cerutti E., Steyn E., Hsabo E. A., Kapetanakis E. I., Kaouras E., Schneck E., Akin E., Gonullu E., celik E., Cicuttin E., Pinotti E., Johnsson E., Moore E. E., Agastra E., Dimitrov E. N., Griffiths E. A., D'Acapito F., Saraceno F., Alconchel F., Zeppernick F. A., Rodriguez F. M., Abu-Zidan F., Pecchini F., Favi F., Ferrara F., Fleres F., Pata F., Roscio F. P. M., Mulita F., Dor F. J. M. F., Linder F., Dimofte G., Rodrigues G., Nita G., Sganga G., Martines G., Mazzarella G., Perrone G., Velmahos G., Lianos G. D., Tomadze G., Baiocchi G. L., D'Ambrosio G., Pellino G., Pattacini G. C., Giraudo G., Lisi G., Tebala G. D., Pirozzolo G., Montori G., Argenio G., Brisinda G., Curro G., Giuliani G., Palomba G., Roscitano G., Avsar G., Augustin G., Clarizia G., Vega G. M. M., Fraga G. P., Sethi H., Eltyeb H. A., Lohse H. A. S., Lohse H. R. S., Bayhan H., Hamid H. K. S., Kryvoruchko I. A., Iannone I., Wani I., Lazaridis I. I., Katsaros I., Nikolopoulos I., Negoi I., Reccia I., Di Carlo I., Olaoye I. O., Czepiel J., Kim J. I., Meyer J., Terrazas J. M. S., Tochie J. N., Galante J. M., Davies J., Sugand K., Gonfa K. B., Rasa K., Kok K. Y. Y., Apostolou K. G., Lasithiotakis K., Tsekouras K., Angamuthu K., Akhmeteli L., Sydorchuk L., Fortuna L., Siragusa L., Pagani L., Solaini L., Miller L. A., Bains L., Ansaloni L., Ferrario L., Bonavina L., Conti L., Buonomo L. A., Tallon-Aguilar L., Tomczyk L., Widmer L. W., Waledziak M., Gachabayov M., Bulanauca M. M., Malbrain M. L. N. G., Maegele M., Catarci M., Ceresoli M., Ranucci M. C., Antonopoulou M. I., Papadoliopoulou M., Valenti M. R., Sotiropoulou M., D'Oria M., Martin M. S., Hirschburger M., Veroux M., Fantoni M., Nardi M., Tolonen M., Montuori M., Podda M., Scheiterle M., Frountzas M., Sarikaya M., Yildirim M., Bender M., Vailas M., Teuben M., Campanelli M., Ammendola M., Malerba M., Pisano M., Pertea M., Slavchev M., Ukkonen M., Bala M., Chirica M., Barone M., Shaat M. M., Mohammed M. J. S., Abuelgasim M. A. A., Gureh M., Ouadii M., Balkan M., Mohamed M., Hakseven M., Velenciuc N., Cillara N., de'Angelis N., Tamini N., Zavras N. J., Machairas N., Michalopoulos N., Koliakos N. N., Pararas N., Donlon N. E., Medappil N., Ben-Ishay O., Stefano O., Islam O., Tammo O., Ioannidis O., Aparicio O., Baraket O., Kumar P., Cianci P., Ortenwall P., Uchikov P. A., de Reuver P., Stahel P. F., Barie P. S., Piccoli M., Major P., Navsaria P. H., Sasmal P. K., Coimbra R., Rahim R., Capoglu R., Koshy R. M., Gonsaga R. A. T., Pertile R., Mohamed R. R. M., Deryol R., Sawyer R. G., Angelico R., Ragozzino R., Bini R., Cammarata R., Scaramuzzo R., Gioco R., Sydorchuk R., Ahmed S., Di Saverio S., Emile S. H., Delibegovic S., Marwah S., Symeonidis S., Thomas S. G., Demir S., Awad S. S., Atici S. D., Chooklin S., Meric S., Sarikaya S., Chowdhury S., Mirghani S. F., Wren S. M., Gargarella S., Del Monte S. R., Esposito S., Xenaki S., Mohamed S. F. G., Beka S. G., Lunca S., Delis S. G., Dritsas S., Morarasu S., Magnone S., Rossi S., Bitsianis S., Kykalos S., Baral S., Jain S. A., Ali S. M., Pintar T., Triantafyllou T., Delko T., Perra T., Sidiropoulos T. A., Scalea T. M., Vilz T. O., Hardcastle T. C., Wannatoop T., Herzog T., Mishra T. S., Boggi U., Calu V., Tomajer V., Agnoletti V., Lohsiriwat V., Kong V., Munoz-Cruzado V. D., Shelat V. G., Khokha V., Ghannam W. M., Biffl W. L., Zuidema W., Kara Y., Kobe Y., Demetrashvili Z., Memish Z. A., Madrazo Z., Balogh Z. J., and Bayhan Z.
Abstract: Background: The SARS-CoV-2 pandemic is still ongoing and a major challenge for health care services worldwide. In the first WSES COVID-19 emergency surgery survey, a strong negative impact on emergency surgery (ES) had been described already early in the pandemic situation. However, the knowledge is limited about current effects of the pandemic on patient flow through emergency rooms, daily routine and decision making in ES as well as their changes over time during the last two pandemic years. This second WSES COVID-19 emergency surgery survey investigates the impact of the SARS-CoV-2 pandemic on ES during the course of the pandemic. Methods: A web survey had been distributed to medical specialists in ES during a four-week period from January 2022, investigating the impact of the pandemic on patients and septic diseases both requiring ES, structural problems due to the pandemic and time-to-intervention in ES routine. Results: 367 collaborators from 59 countries responded to the survey. The majority indicated that the pandemic still significantly impacts on treatment and outcome of surgical emergency patients (83.1% and 78.5%, respectively). As reasons, the collaborators reported decreased case load in ES (44.7%), but patients presenting with more prolonged and severe diseases, especially concerning perforated appendicitis (62.1%) and diverticulitis (57.5%). Otherwise, approximately 50% of the participants still observe a delay in time-to-intervention in ES compared with the situation before the pandemic. Relevant causes leading to enlarged time-to-intervention in ES during the pandemic are persistent problems with in-hospital logistics, lacks in medical staff as well as operating room and intensive care capacities during the pandemic. This leads not only to the need for triage or transferring of ES patients to other hospitals, reported by 64.0% and 48.8% of the collaborators, respectively, but also to paradigm shifts in treatment modalities to non-operative approach
Published: 2022

5. Corrigendum to ‘An international genome-wide meta-analysis of primary biliary cholangitis: Novel risk loci and candidate drugs’ [J Hepatol 2021;75(3):572–581] (Journal of Hepatology (2021) 75(3) (572–581), (S0168827821003342), (10.1016/j.jhep.2021.04.055))

Author: Cordell H. 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J., Fryett J. J., Ueno K., Darlay R., Aiba Y., Hitomi Y., Kawashima M., Nishida N., Khor S. -S., Gervais O., Kawai Y., Nagasaki M., Tokunaga K., Tang R., Shi Y., Li Z., Juran B. D., Atkinson E. J., Gerussi A., Carbone M., Asselta R., Cheung A., de Andrade M., Baras A., Horowitz J., Ferreira M. A. R., Sun D., Jones D. E., Flack S., Spicer A., Mulcahy V. L., Byun J., Han Y., Sandford R. N., Lazaridis K. N., Amos C. I., Hirschfield G. M., Seldin M. F., Invernizzi P., Siminovitch K. A., Ma X., Nakamura M., Mells G. F., Mason A., Vincent C., Xie G., Zhang J., Affronti A., Almasio P. L., Alvaro D., Andreone P., Andriulli A., Azzaroli F., Battezzati P. M., Benedetti A., Bragazzi M. C., Brunetto M., Bruno S., Calvaruso V., Cardinale V., Casella G., Cazzagon N., Ciaccio A., Coco B., Colli A., Colloredo G., Colombo M., Colombo S., Cristoferi L., Cursaro C., Croce L. S., Crosignani A., D'Amato D., Donato F., Elia G., Fabris L., Fagiuoli S., Ferrari C., Floreani A., Galli A., Giannini E., Grattagliano I., Lampertico P., Lleo A., Malinverno F., Mancuso C., Marra F., Marzioni M., Massironi S., Mattalia A., Miele L., Milani C., Morini L., Morisco F., Muratori L., Muratori P., Niro G. A., O'Donnell S., Picciotto A., Portincasa P., Rigamonti C., Ronca V., Rosina F., Spinzi G., Strazzabosco M., Tiribelli C., Toniutto P., Valenti L., Vinci M., Zuin M., Nakamura H., Abiru S., Nagaoka S., Komori A., Yatsuhashi H., Ishibashi H., Ito M., Migita K., Ohira H., Katsushima S., Naganuma A., Sugi K., Komatsu T., Mannami T., Matsushita K., Yoshizawa K., Makita F., Nikami T., Nishimura H., Kouno H., Ota H., Komura T., Nakamura Y., Shimada M., Hirashima N., Komeda T., Ario K., Nakamuta M., Yamashita T., Furuta K., Kikuchi M., Naeshiro N., Takahashi H., Mano Y., Tsunematsu S., Yabuuchi I., Shimada Y., Yamauchi K., Sugimoto R., Sakai H., Mita E., Koda M., Tsuruta S., Kamitsukasa H., Sato T., Masaki N., Kobata T., Fukushima N., Ohara Y., Muro T., Takesaki E., Takaki H., Yamamoto T., Kato M., Nagaoki Y., Hayashi S., Ishida J., Watanabe Y., Kobayashi M., Koga M., Saoshiro T., Yagura M., Hirata K., Tanaka A., Takikawa H., Zeniya M., Abe M., Onji M., Kaneko S., Honda M., Arai K., Arinaga-Hino T., Hashimoto E., Taniai M., Umemura T., Joshita S., Nakao K., Ichikawa T., Shibata H., Yamagiwa S., Seike M., Honda K., Sakisaka S., Takeyama Y., Harada M., Senju M., Yokosuka O., Kanda T., Ueno Y., Kikuchi K., Ebinuma H., Himoto T., Yasunami M., Murata K., Mizokami M., Kawata K., Shimoda S., Miyake Y., Takaki A., Yamamoto K., Hirano K., Ichida T., Ido A., Tsubouchi H., Chayama K., Harada K., Nakanuma Y., Maehara Y., Taketomi A., Shirabe K., Soejima Y., Mori A., Yagi S., Uemoto S., H E., Tanaka T., Yamashiki N., Tamura S., Sugawara Y., Kokudo N., Chalasani N., Luketic V., Odin J., Chopra K., Abecasis G., Cantor M., Coppola G., Economides A., Lotta L. A., Overton J. D., Reid J. G., Shuldiner A., Beechert C., Forsythe C., Fuller E. D., Gu Z., Lattari M., Lopez A., Schleicher T. D., Padilla M. S., Toledo K., Widom L., Wolf S. E., Pradhan M., Manoochehri K., Ulloa R. H., Bai X., Balasubramanian S., Barnard L., Blumenfeld A., Eom G., Habegger L., Hawes A., Khalid S., Maxwell E. K., Salerno W., Staples J. C., Jones M. B., Mitnaul L. J., Sturgess R., Healey C., Yeoman A., Gunasekera A. V. J., Kooner P., Kapur K., Sathyanarayana V., Kallis Y., Subhani J., Harvey R., McCorry R., Rooney P., Ramanaden D., Evans R., Mathialahan T., Gasem J., Shorrock C., Bhalme M., Southern P., Tibble J. A., Gorard D. A., Jones S., Mells G., Mulcahy V., Srivastava B., Foxton M. R., Collins C. E., Elphick D., Karmo M., Porras-Perez F., Mendall M., Yapp T., Patel M., Ede R., Sayer J., Jupp J., Fisher N., Carter M. J., Koss K., Shah J., Piotrowicz A., Scott G., Grimley C., Gooding I. R., Williams S., Tidbury J., Lim G., Cheent K., Levi S., Mansour D., Beckley M., Hollywood C., Wong T., Marley R., Ramage J., Gordon H. M., Ridpath J., Ngatchu T., Bob Grover V. P., Shidrawi R. G., Abouda G., Corless L., Narain M., Rees I., Brown A., Taylor-Robinson S., Wilkins J., Grellier L., Banim P., Das D., Heneghan M. A., Curtis H., Matthews H. C., Mohammed F., Aldersley M., Srirajaskanthan R., Walker G., McNair A., Sharif A., Sen S., Bird G., Prince M. I., Prasad G., Kitchen P., Barnardo A., Oza C., Sivaramakrishnan N. N., Gupta P., Shah A., Evans C. D. J., Saha S., Pollock K., Bramley P., Mukhopadhya A., Barclay S. T., McDonald N., Bathgate A. J., Palmer K., Dillon J. F., Rushbrook S. M., Przemioslo R., McDonald C., Millar A., Tai C., Mitchell S., Metcalf J., Shaukat S., Ninkovic M., Shmueli U., Davis A., Naqvi A., Lee T. J. W., Ryder S., Collier J., Klass H., Cramp M. E., Sharer N., Aspinall R., Ghosh D., Douds A. C., Booth J., Williams E., Hussaini H., Christie J., Mann S., Thorburn D., Marshall A., Patanwala I., Ala A., Maltby J., Matthew R., Corbett C., Vyas S., Singhal S., Gleeson D., Misra S., Butterworth J., George K., Harding T., Douglass A., Mitchison H., Panter S., Shearman J., Bray G., Roberts M., Butcher G., Forton D., Mahmood Z., Cowan M., Ch'ng C. L., Rahman M., Whatley G. C. A., Wesley E., Mandal A., Jain S., Pereira S. P., Wright M., Trivedi P., Gordon F. H., Unitt E., Palejwala A., Austin A., Vemala V., Grant A., Higham A. D., Brind A., Mathew R., Cox M., Ramakrishnan S., King A., Whalley S., Fraser J., Thomson S. J., Bell A., Wong V. S., Kia R., Gee I., Keld R., Ransford R., Gotto J., Millson C., Tarocchi M., Cordell H. J., Cordell, H, Fryett, J, Ueno, K, Darlay, R, Aiba, Y, Hitomi, Y, Kawashima, M, Nishida, N, Khor, S, Gervais, O, Kawai, Y, Nagasaki, M, Tokunaga, K, Tang, R, Shi, Y, Li, Z, Juran, B, Atkinson, E, Gerussi, A, Carbone, M, Asselta, R, Cheung, A, de Andrade, M, Baras, A, Horowitz, J, Ferreira, M, Sun, D, Jones, D, Flack, S, Spicer, A, Mulcahy, V, Byun, J, Han, Y, Sandford, R, Lazaridis, K, Amos, C, Hirschfield, G, Seldin, M, Invernizzi, P, Siminovitch, K, Ma, X, Nakamura, M, Mells, G, Mason, A, Vincent, C, Xie, G, Zhang, J, Affronti, A, Almasio, P, Alvaro, D, Andreone, P, Andriulli, A, Azzaroli, F, Battezzati, P, Benedetti, A, Bragazzi, M, Brunetto, M, Bruno, S, Calvaruso, V, Cardinale, V, Casella, G, Cazzagon, N, Ciaccio, A, Coco, B, Colli, A, Colloredo, G, Colombo, M, Colombo, S, Cristoferi, L, Cursaro, C, Croce, L, Crosignani, A, D'Amato, D, Donato, F, Elia, G, Fabris, L, Fagiuoli, S, Ferrari, C, Floreani, A, Galli, A, Giannini, E, Grattagliano, I, Lampertico, P, Lleo, A, Malinverno, F, Mancuso, C, Marra, F, Marzioni, M, Massironi, S, Mattalia, A, Miele, L, Milani, C, Morini, L, Morisco, F, Muratori, L, Muratori, P, Niro, G, O'Donnell, S, Picciotto, A, Portincasa, P, Rigamonti, C, Ronca, V, Rosina, F, Spinzi, G, Strazzabosco, M, Tiribelli, C, Toniutto, P, Valenti, L, Vinci, M, Zuin, M, Nakamura, H, Abiru, S, Nagaoka, S, Komori, A, Yatsuhashi, H, Ishibashi, H, Ito, M, Migita, K, Ohira, H, Katsushima, S, Naganuma, A, Sugi, K, Komatsu, T, Mannami, T, Matsushita, K, Yoshizawa, K, Makita, F, Nikami, T, Nishimura, H, Kouno, H, Ota, H, Komura, T, Nakamura, Y, Shimada, M, Hirashima, N, Komeda, T, Ario, K, Nakamuta, M, Yamashita, T, Furuta, K, Kikuchi, M, Naeshiro, N, Takahashi, H, Mano, Y, Tsunematsu, S, Yabuuchi, I, Shimada, Y, Yamauchi, K, Sugimoto, R, Sakai, H, Mita, E, Koda, M, Tsuruta, S, Kamitsukasa, H, Sato, T, Masaki, N, Kobata, T, Fukushima, N, Ohara, Y, Muro, T, Takesaki, E, Takaki, H, Yamamoto, T, Kato, M, Nagaoki, Y, Hayashi, S, Ishida, J, Watanabe, Y, Kobayashi, M, Koga, M, Saoshiro, T, Yagura, M, Hirata, K, Tanaka, A, Takikawa, H, Zeniya, M, Abe, M, Onji, M, Kaneko, S, Honda, M, Arai, K, Arinaga-Hino, T, Hashimoto, E, Taniai, M, Umemura, T, Joshita, S, Nakao, K, Ichikawa, T, Shibata, H, Yamagiwa, S, Seike, M, Honda, K, Sakisaka, S, Takeyama, Y, Harada, M, Senju, M, Yokosuka, O, Kanda, T, Ueno, Y, Kikuchi, K, Ebinuma, H, Himoto, T, Yasunami, M, Murata, K, Mizokami, M, Kawata, K, Shimoda, S, Miyake, Y, Takaki, A, Yamamoto, K, Hirano, K, Ichida, T, Ido, A, Tsubouchi, H, Chayama, K, Harada, K, Nakanuma, Y, Maehara, Y, Taketomi, A, Shirabe, K, Soejima, Y, Mori, A, Yagi, S, Uemoto, S, H, E, Tanaka, T, Yamashiki, N, Tamura, S, Sugawara, Y, Kokudo, N, Chalasani, N, Luketic, V, Odin, J, Chopra, K, Abecasis, G, Cantor, M, Coppola, G, Economides, A, Lotta, L, Overton, J, Reid, J, Shuldiner, A, Beechert, C, Forsythe, C, Fuller, E, Gu, Z, Lattari, M, Lopez, A, Schleicher, T, Padilla, M, Toledo, K, Widom, L, Wolf, S, Pradhan, M, Manoochehri, K, Ulloa, R, Bai, X, Balasubramanian, S, Barnard, L, Blumenfeld, A, Eom, G, Habegger, L, Hawes, A, Khalid, S, Maxwell, E, Salerno, W, Staples, J, Jones, M, Mitnaul, L, Sturgess, R, Healey, C, Yeoman, A, Gunasekera, A, Kooner, P, Kapur, K, Sathyanarayana, V, Kallis, Y, Subhani, J, Harvey, R, Mccorry, R, Rooney, P, Ramanaden, D, Evans, R, Mathialahan, T, Gasem, J, Shorrock, C, Bhalme, M, Southern, P, Tibble, J, Gorard, D, Jones, S, Srivastava, B, Foxton, M, Collins, C, Elphick, D, Karmo, M, Porras-Perez, F, Mendall, M, Yapp, T, Patel, M, Ede, R, Sayer, J, Jupp, J, Fisher, N, Carter, M, Koss, K, Shah, J, Piotrowicz, A, Scott, G, Grimley, C, Gooding, I, Williams, S, Tidbury, J, Lim, G, Cheent, K, Levi, S, Mansour, D, Beckley, M, Hollywood, C, Wong, T, Marley, R, Ramage, J, Gordon, H, Ridpath, J, Ngatchu, T, Bob Grover, V, Shidrawi, R, Abouda, G, Corless, L, Narain, M, Rees, I, Brown, A, Taylor-Robinson, S, Wilkins, J, Grellier, L, Banim, P, Das, D, Heneghan, M, Curtis, H, Matthews, H, Mohammed, F, Aldersley, M, Srirajaskanthan, R, Walker, G, Mcnair, A, Sharif, A, Sen, S, Bird, G, Prince, M, Prasad, G, Kitchen, P, Barnardo, A, Oza, C, Sivaramakrishnan, N, Gupta, P, Shah, A, Evans, C, Saha, S, Pollock, K, Bramley, P, Mukhopadhya, A, Barclay, S, Mcdonald, N, Bathgate, A, Palmer, K, Dillon, J, Rushbrook, S, Przemioslo, R, Mcdonald, C, Millar, A, Tai, C, Mitchell, S, Metcalf, J, Shaukat, S, Ninkovic, M, Shmueli, U, Davis, A, Naqvi, A, Lee, T, Ryder, S, Collier, J, Klass, H, Cramp, M, Sharer, N, Aspinall, R, Ghosh, D, Douds, A, Booth, J, Williams, E, Hussaini, H, Christie, J, Mann, S, Thorburn, D, Marshall, A, Patanwala, I, Ala, A, Maltby, J, Matthew, R, Corbett, C, Vyas, S, Singhal, S, Gleeson, D, Misra, S, Butterworth, J, George, K, Harding, T, Douglass, A, Mitchison, H, Panter, S, Shearman, J, Bray, G, Roberts, M, Butcher, G, Forton, D, Mahmood, Z, Cowan, M, Ch'Ng, C, Rahman, M, Whatley, G, Wesley, E, Mandal, A, Jain, S, Pereira, S, Wright, M, Trivedi, P, Gordon, F, Unitt, E, Palejwala, A, Austin, A, Vemala, V, Grant, A, Higham, A, Brind, A, Mathew, R, Cox, M, Ramakrishnan, S, King, A, Whalley, S, Fraser, J, Thomson, S, Bell, A, Wong, V, Kia, R, Gee, I, Keld, R, Ransford, R, Gotto, J, Millson, C, Tarocchi, M, Cordell H. J., Fryett J. J., Ueno K., Darlay R., Aiba Y., Hitomi Y., Kawashima M., Nishida N., Khor S. -S., Gervais O., Kawai Y., Nagasaki M., Tokunaga K., Tang R., Shi Y., Li Z., Juran B. D., Atkinson E. J., Gerussi A., Carbone M., Asselta R., Cheung A., de Andrade M., Baras A., Horowitz J., Ferreira M. A. R., Sun D., Jones D. E., Flack S., Spicer A., Mulcahy V. L., Byun J., Han Y., Sandford R. N., Lazaridis K. N., Amos C. I., Hirschfield G. M., Seldin M. F., Invernizzi P., Siminovitch K. A., Ma X., Nakamura M., Mells G. F., Mason A., Vincent C., Xie G., Zhang J., Affronti A., Almasio P. L., Alvaro D., Andreone P., Andriulli A., Azzaroli F., Battezzati P. M., Benedetti A., Bragazzi M. C., Brunetto M., Bruno S., Calvaruso V., Cardinale V., Casella G., Cazzagon N., Ciaccio A., Coco B., Colli A., Colloredo G., Colombo M., Colombo S., Cristoferi L., Cursaro C., Croce L. S., Crosignani A., D'Amato D., Donato F., Elia G., Fabris L., Fagiuoli S., Ferrari C., Floreani A., Galli A., Giannini E., Grattagliano I., Lampertico P., Lleo A., Malinverno F., Mancuso C., Marra F., Marzioni M., Massironi S., Mattalia A., Miele L., Milani C., Morini L., Morisco F., Muratori L., Muratori P., Niro G. A., O'Donnell S., Picciotto A., Portincasa P., Rigamonti C., Ronca V., Rosina F., Spinzi G., Strazzabosco M., Tiribelli C., Toniutto P., Valenti L., Vinci M., Zuin M., Nakamura H., Abiru S., Nagaoka S., Komori A., Yatsuhashi H., Ishibashi H., Ito M., Migita K., Ohira H., Katsushima S., Naganuma A., Sugi K., Komatsu T., Mannami T., Matsushita K., Yoshizawa K., Makita F., Nikami T., Nishimura H., Kouno H., Ota H., Komura T., Nakamura Y., Shimada M., Hirashima N., Komeda T., Ario K., Nakamuta M., Yamashita T., Furuta K., Kikuchi M., Naeshiro N., Takahashi H., Mano Y., Tsunematsu S., Yabuuchi I., Shimada Y., Yamauchi K., Sugimoto R., Sakai H., Mita E., Koda M., Tsuruta S., Kamitsukasa H., Sato T., Masaki N., Kobata T., Fukushima N., Ohara Y., Muro T., Takesaki E., Takaki H., Yamamoto T., Kato M., Nagaoki Y., Hayashi S., Ishida J., Watanabe Y., Kobayashi M., Koga M., Saoshiro T., Yagura M., Hirata K., Tanaka A., Takikawa H., Zeniya M., Abe M., Onji M., Kaneko S., Honda M., Arai K., Arinaga-Hino T., Hashimoto E., Taniai M., Umemura T., Joshita S., Nakao K., Ichikawa T., Shibata H., Yamagiwa S., Seike M., Honda K., Sakisaka S., Takeyama Y., Harada M., Senju M., Yokosuka O., Kanda T., Ueno Y., Kikuchi K., Ebinuma H., Himoto T., Yasunami M., Murata K., Mizokami M., Kawata K., Shimoda S., Miyake Y., Takaki A., Yamamoto K., Hirano K., Ichida T., Ido A., Tsubouchi H., Chayama K., Harada K., Nakanuma Y., Maehara Y., Taketomi A., Shirabe K., Soejima Y., Mori A., Yagi S., Uemoto S., H E., Tanaka T., Yamashiki N., Tamura S., Sugawara Y., Kokudo N., Chalasani N., Luketic V., Odin J., Chopra K., Abecasis G., Cantor M., Coppola G., Economides A., Lotta L. A., Overton J. D., Reid J. G., Shuldiner A., Beechert C., Forsythe C., Fuller E. D., Gu Z., Lattari M., Lopez A., Schleicher T. D., Padilla M. S., Toledo K., Widom L., Wolf S. E., Pradhan M., Manoochehri K., Ulloa R. H., Bai X., Balasubramanian S., Barnard L., Blumenfeld A., Eom G., Habegger L., Hawes A., Khalid S., Maxwell E. K., Salerno W., Staples J. C., Jones M. B., Mitnaul L. J., Sturgess R., Healey C., Yeoman A., Gunasekera A. V. J., Kooner P., Kapur K., Sathyanarayana V., Kallis Y., Subhani J., Harvey R., McCorry R., Rooney P., Ramanaden D., Evans R., Mathialahan T., Gasem J., Shorrock C., Bhalme M., Southern P., Tibble J. A., Gorard D. A., Jones S., Mells G., Mulcahy V., Srivastava B., Foxton M. R., Collins C. E., Elphick D., Karmo M., Porras-Perez F., Mendall M., Yapp T., Patel M., Ede R., Sayer J., Jupp J., Fisher N., Carter M. J., Koss K., Shah J., Piotrowicz A., Scott G., Grimley C., Gooding I. R., Williams S., Tidbury J., Lim G., Cheent K., Levi S., Mansour D., Beckley M., Hollywood C., Wong T., Marley R., Ramage J., Gordon H. M., Ridpath J., Ngatchu T., Bob Grover V. P., Shidrawi R. G., Abouda G., Corless L., Narain M., Rees I., Brown A., Taylor-Robinson S., Wilkins J., Grellier L., Banim P., Das D., Heneghan M. A., Curtis H., Matthews H. C., Mohammed F., Aldersley M., Srirajaskanthan R., Walker G., McNair A., Sharif A., Sen S., Bird G., Prince M. I., Prasad G., Kitchen P., Barnardo A., Oza C., Sivaramakrishnan N. N., Gupta P., Shah A., Evans C. D. J., Saha S., Pollock K., Bramley P., Mukhopadhya A., Barclay S. T., McDonald N., Bathgate A. J., Palmer K., Dillon J. F., Rushbrook S. M., Przemioslo R., McDonald C., Millar A., Tai C., Mitchell S., Metcalf J., Shaukat S., Ninkovic M., Shmueli U., Davis A., Naqvi A., Lee T. J. W., Ryder S., Collier J., Klass H., Cramp M. E., Sharer N., Aspinall R., Ghosh D., Douds A. C., Booth J., Williams E., Hussaini H., Christie J., Mann S., Thorburn D., Marshall A., Patanwala I., Ala A., Maltby J., Matthew R., Corbett C., Vyas S., Singhal S., Gleeson D., Misra S., Butterworth J., George K., Harding T., Douglass A., Mitchison H., Panter S., Shearman J., Bray G., Roberts M., Butcher G., Forton D., Mahmood Z., Cowan M., Ch'ng C. L., Rahman M., Whatley G. C. A., Wesley E., Mandal A., Jain S., Pereira S. P., Wright M., Trivedi P., Gordon F. H., Unitt E., Palejwala A., Austin A., Vemala V., Grant A., Higham A. D., Brind A., Mathew R., Cox M., Ramakrishnan S., King A., Whalley S., Fraser J., Thomson S. J., Bell A., Wong V. S., Kia R., Gee I., Keld R., Ransford R., Gotto J., Millson C., and Tarocchi M.
Abstract: It has come to our attention that the name of one of the authors in our manuscript was incorrectly spelled ‘Jinyoung Byan’; the correct spelling is ‘Jinyoung Byun’ as in the author list above. In addition, the excel files of the supplementary tables were not included during the online publication of our article. These have now been made available online. We apologize for any inconvenience caused.
Published: 2022

6. A genetic history of the Balkans from Roman frontier to Slavic migrations

Author: Olalde, Inigo, Carrion, Pablo, Mikić, Ilija, Rohland, Nadin, Mallick, Swapan, Lazaridis, Iosif, Mah, Matthew, Korać, Miomir, Golubović, Snežana, Petković, Sofija, Miladinović-Radmilović, Nataša, Vulović, Dragana, Alihodžić, Timka, Ash, Abigail, Baeta, Miriam, Bartık, Juraj, Bedić, Željka, Bilić, Maja, Bonsall, Clive, Bunčić, Maja, Bunčić, Domagoj, Carić, Mario, Čataj, Lea, Cvetko, Mirna, Drnić, Ivan, Dugonjić, Anita, Đukić, Ana, Đukić, Ksenija, Farkaš, Zdenek, Jelınek, Pavol, Jovanovic, Marija, Kaić, Iva, Kalafatić, Hrvoje, Krmpotić, Marijana, Krznar, Siniša, Leleković, Tino, M. de Pancorbo, Marian, Matijević, Vinka, Milosević Zakić, Branka, J. Osterholtz, Anna, M. Paige, Julianne, Dinko, Tresić Pavičić, Premužić, Zrinka, Rajić Sikanjić, Petra, Rapan Papeša, Anita, Paraman, Lujana, Sanader, Mirjana, Radovanović, Ivana, Roksandic, Mirjana, Sefcakova, Alena, Stefanović, Sofia, Teschler-Nicola, Maria, Toncinić, Domagoj, Olalde, Inigo, Carrion, Pablo, Mikić, Ilija, Rohland, Nadin, Mallick, Swapan, Lazaridis, Iosif, Mah, Matthew, Korać, Miomir, Golubović, Snežana, Petković, Sofija, Miladinović-Radmilović, Nataša, Vulović, Dragana, Alihodžić, Timka, Ash, Abigail, Baeta, Miriam, Bartık, Juraj, Bedić, Željka, Bilić, Maja, Bonsall, Clive, Bunčić, Maja, Bunčić, Domagoj, Carić, Mario, Čataj, Lea, Cvetko, Mirna, Drnić, Ivan, Dugonjić, Anita, Đukić, Ana, Đukić, Ksenija, Farkaš, Zdenek, Jelınek, Pavol, Jovanovic, Marija, Kaić, Iva, Kalafatić, Hrvoje, Krmpotić, Marijana, Krznar, Siniša, Leleković, Tino, M. de Pancorbo, Marian, Matijević, Vinka, Milosević Zakić, Branka, J. Osterholtz, Anna, M. Paige, Julianne, Dinko, Tresić Pavičić, Premužić, Zrinka, Rajić Sikanjić, Petra, Rapan Papeša, Anita, Paraman, Lujana, Sanader, Mirjana, Radovanović, Ivana, Roksandic, Mirjana, Sefcakova, Alena, Stefanović, Sofia, Teschler-Nicola, Maria, and Toncinić, Domagoj
Abstract: The rise and fall of the Roman Empire was a socio-political process with enormous ramifications for humanhistory. The Middle Danube was a crucial frontier and a crossroads for population and cultural movement.Here, we present genome-wide data from 136 Balkan individuals dated to the 1st millennium CE. Despiteextensive militarization and cultural influence, we find little ancestry contribution from peoples of Italicdescent. However, we trace a large-scale influx of people of Anatolian ancestry during the Imperial period.Between 250 and 550 CE, we detect migrants with ancestry from Central/Northern Europe and the Steppe,confirming that ‘‘barbarian’’ migrations were propelled by ethnically diverse confederations. Following theend of Roman control, we detect the large-scale arrival of individuals who were genetically similar to modernEastern European Slavic-speaking populations, who contributed 30%–60% of the ancestry of Balkan people,representing one of the largest permanent demographic changes anywhere in Europe during the MigrationPeriod.
Published: 2023

7. Ambient temperature gas phase sulfonation: A mild route towards acid functionalized ordered mesoporous organosilica

Author: Sandbrink, Lennart, Lazaridis, Timon, Rose, Marcus, Palkovits, Regina, Sandbrink, Lennart, Lazaridis, Timon, Rose, Marcus, and Palkovits, Regina
Abstract: Sulfonation is a versatile method for the production of acidic materials, e. g. for applications in catalysis. In this study different sulfonation techniques for the production of acidic ordered mesoporous materials are investigated. SBA-15-like mesoporous organosilanes bearing aromatic moieties are sulfonated in the liquid phase with oleum as well as in the gas phase under significantly milder conditions with sulfur trioxide. Functionalization via liquid phase sulfonation at elevated temperatures proceeds at the expense of partial or complete collapse of the pore system. In contrast, gas phase sulfonation with sulfur trioxide at ambient temperature allows for similar sulfonation yields, while maintaining the textural properties due to the milder reaction conditions. Overall, acid functionalization of mesoporous organosilica using a gas phase sulfonation route is reported for the first time, enabling both high acid capacities and preservation of the pore structure.
Published: 2023

8. A genetic history of the Balkans from Roman frontier to Slavic migrations

Author: Olalde, Inigo, Carrion, Pablo, Mikić, Ilija, Rohland, Nadin, Mallick, Swapan, Lazaridis, Iosif, Mah, Matthew, Korać, Miomir, Golubović, Snežana, Petković, Sofija, Miladinović-Radmilović, Nataša, Vulović, Dragana, Alihodžić, Timka, Ash, Abigail, Baeta, Miriam, Bartık, Juraj, Bedić, Željka, Bilić, Maja, Bonsall, Clive, Bunčić, Maja, Bunčić, Domagoj, Carić, Mario, Čataj, Lea, Cvetko, Mirna, Drnić, Ivan, Dugonjić, Anita, Đukić, Ana, Đukić, Ksenija, Farkaš, Zdenek, Jelınek, Pavol, Jovanovic, Marija, Kaić, Iva, Kalafatić, Hrvoje, Krmpotić, Marijana, Krznar, Siniša, Leleković, Tino, M. de Pancorbo, Marian, Matijević, Vinka, Milosević Zakić, Branka, J. Osterholtz, Anna, M. Paige, Julianne, Dinko, Tresić Pavičić, Premužić, Zrinka, Rajić Sikanjić, Petra, Rapan Papeša, Anita, Paraman, Lujana, Sanader, Mirjana, Radovanović, Ivana, Roksandic, Mirjana, Sefcakova, Alena, Stefanović, Sofia, Teschler-Nicola, Maria, Toncinić, Domagoj, Olalde, Inigo, Carrion, Pablo, Mikić, Ilija, Rohland, Nadin, Mallick, Swapan, Lazaridis, Iosif, Mah, Matthew, Korać, Miomir, Golubović, Snežana, Petković, Sofija, Miladinović-Radmilović, Nataša, Vulović, Dragana, Alihodžić, Timka, Ash, Abigail, Baeta, Miriam, Bartık, Juraj, Bedić, Željka, Bilić, Maja, Bonsall, Clive, Bunčić, Maja, Bunčić, Domagoj, Carić, Mario, Čataj, Lea, Cvetko, Mirna, Drnić, Ivan, Dugonjić, Anita, Đukić, Ana, Đukić, Ksenija, Farkaš, Zdenek, Jelınek, Pavol, Jovanovic, Marija, Kaić, Iva, Kalafatić, Hrvoje, Krmpotić, Marijana, Krznar, Siniša, Leleković, Tino, M. de Pancorbo, Marian, Matijević, Vinka, Milosević Zakić, Branka, J. Osterholtz, Anna, M. Paige, Julianne, Dinko, Tresić Pavičić, Premužić, Zrinka, Rajić Sikanjić, Petra, Rapan Papeša, Anita, Paraman, Lujana, Sanader, Mirjana, Radovanović, Ivana, Roksandic, Mirjana, Sefcakova, Alena, Stefanović, Sofia, Teschler-Nicola, Maria, and Toncinić, Domagoj
Abstract: The rise and fall of the Roman Empire was a socio-political process with enormous ramifications for human history. The Middle Danube was a crucial frontier and a crossroads for population and cultural movement. Here, we present genome-wide data from 136 Balkan individuals dated to the 1st millennium CE. Despite extensive militarization and cultural influence, we find little ancestry contribution from peoples of Italic descent. However, we trace a large-scale influx of people of Anatolian ancestry during the Imperial period. Between 250 and 550 CE, we detect migrants with ancestry from Central/Northern Europe and the Steppe, confirming that ‘‘barbarian’’ migrations were propelled by ethnically diverse confederations. Following the end of Roman control, we detect the large-scale arrival of individuals who were genetically similar to modern Eastern European Slavic-speaking populations, who contributed 30%–60% of the ancestry of Balkan people, representing one of the largest permanent demographic changes anywhere in Europe during the Migration Period.
Published: 2023

9. Ambient temperature gas phase sulfonation: A mild route towards acid functionalized ordered mesoporous organosilica

Author: Sandbrink, Lennart, Lazaridis, Timon, Rose, Marcus, Palkovits, Regina, Sandbrink, Lennart, Lazaridis, Timon, Rose, Marcus, and Palkovits, Regina
Abstract: Sulfonation is a versatile method for the production of acidic materials, e. g. for applications in catalysis. In this study different sulfonation techniques for the production of acidic ordered mesoporous materials are investigated. SBA-15-like mesoporous organosilanes bearing aromatic moieties are sulfonated in the liquid phase with oleum as well as in the gas phase under significantly milder conditions with sulfur trioxide. Functionalization via liquid phase sulfonation at elevated temperatures proceeds at the expense of partial or complete collapse of the pore system. In contrast, gas phase sulfonation with sulfur trioxide at ambient temperature allows for similar sulfonation yields, while maintaining the textural properties due to the milder reaction conditions. Overall, acid functionalization of mesoporous organosilica using a gas phase sulfonation route is reported for the first time, enabling both high acid capacities and preservation of the pore structure.
Published: 2023

10. Ambient temperature gas phase sulfonation: A mild route towards acid functionalized ordered mesoporous organosilica

Author: Sandbrink, Lennart, Lazaridis, Timon, Rose, Marcus, Palkovits, Regina, Sandbrink, Lennart, Lazaridis, Timon, Rose, Marcus, and Palkovits, Regina
Abstract: Sulfonation is a versatile method for the production of acidic materials, e. g. for applications in catalysis. In this study different sulfonation techniques for the production of acidic ordered mesoporous materials are investigated. SBA-15-like mesoporous organosilanes bearing aromatic moieties are sulfonated in the liquid phase with oleum as well as in the gas phase under significantly milder conditions with sulfur trioxide. Functionalization via liquid phase sulfonation at elevated temperatures proceeds at the expense of partial or complete collapse of the pore system. In contrast, gas phase sulfonation with sulfur trioxide at ambient temperature allows for similar sulfonation yields, while maintaining the textural properties due to the milder reaction conditions. Overall, acid functionalization of mesoporous organosilica using a gas phase sulfonation route is reported for the first time, enabling both high acid capacities and preservation of the pore structure.
Published: 2023

11. Ambient temperature gas phase sulfonation: A mild route towards acid functionalized ordered mesoporous organosilica

Author: Sandbrink, Lennart, Lazaridis, Timon, Rose, Marcus, Palkovits, Regina, Sandbrink, Lennart, Lazaridis, Timon, Rose, Marcus, and Palkovits, Regina
Abstract: Sulfonation is a versatile method for the production of acidic materials, e. g. for applications in catalysis. In this study different sulfonation techniques for the production of acidic ordered mesoporous materials are investigated. SBA-15-like mesoporous organosilanes bearing aromatic moieties are sulfonated in the liquid phase with oleum as well as in the gas phase under significantly milder conditions with sulfur trioxide. Functionalization via liquid phase sulfonation at elevated temperatures proceeds at the expense of partial or complete collapse of the pore system. In contrast, gas phase sulfonation with sulfur trioxide at ambient temperature allows for similar sulfonation yields, while maintaining the textural properties due to the milder reaction conditions. Overall, acid functionalization of mesoporous organosilica using a gas phase sulfonation route is reported for the first time, enabling both high acid capacities and preservation of the pore structure.
Published: 2023

12. Lucy-SKG: Learning to Play Rocket League Efficiently Using Deep Reinforcement Learning

Author: Moschopoulos, Vasileios, Kyriakidis, Pantelis, Lazaridis, Aristotelis, Vlahavas, Ioannis, Moschopoulos, Vasileios, Kyriakidis, Pantelis, Lazaridis, Aristotelis, and Vlahavas, Ioannis
Abstract: A successful tactic that is followed by the scientific community for advancing AI is to treat games as problems, which has been proven to lead to various breakthroughs. We adapt this strategy in order to study Rocket League, a widely popular but rather under-explored 3D multiplayer video game with a distinct physics engine and complex dynamics that pose a significant challenge in developing efficient and high-performance game-playing agents. In this paper, we present Lucy-SKG, a Reinforcement Learning-based model that learned how to play Rocket League in a sample-efficient manner, outperforming by a notable margin the two highest-ranking bots in this game, namely Necto (2022 bot champion) and its successor Nexto, thus becoming a state-of-the-art agent. Our contributions include: a) the development of a reward analysis and visualization library, b) novel parameterizable reward shape functions that capture the utility of complex reward types via our proposed Kinesthetic Reward Combination (KRC) technique, and c) design of auxiliary neural architectures for training on reward prediction and state representation tasks in an on-policy fashion for enhanced efficiency in learning speed and performance. By performing thorough ablation studies for each component of Lucy-SKG, we showed their independent effectiveness in overall performance. In doing so, we demonstrate the prospects and challenges of using sample-efficient Reinforcement Learning techniques for controlling complex dynamical systems under competitive team-based multiplayer conditions., Comment: 24 pages, 11 figures
Published: 2023

13. Feature-Based Generalized Gaussian Distribution Method for NLoS Detection in Ultra-Wideband (UWB) Indoor Positioning System

Author: Che, Fuhu, Ahmed, Qasim Zeeshan, Fontaine, Jaron, Van Herbruggen, Ben, Shahid, Adnan, De Poorter, Eli, Lazaridis, Pavlos I., Che, Fuhu, Ahmed, Qasim Zeeshan, Fontaine, Jaron, Van Herbruggen, Ben, Shahid, Adnan, De Poorter, Eli, and Lazaridis, Pavlos I.
Abstract: Non-Line-of-Sight (NLoS) propagation condition is a crucial factor affecting the precision of the localization in the Ultra-Wideband (UWB) Indoor Positioning System (IPS). Numerous supervised Machine Learning (ML) approaches have been applied for NLoS identification to improve the accuracy of the IPS. However, it is difficult for existing ML approaches to maintain a high classification accuracy when the database contains a small number of NLoS signals and a large number of Line-of-Sight (LoS) signals. The inaccurate localization of the target node caused by this small number of NLoS signals can still be problematic. To solve this issue, we propose feature-based Gaussian Distribution (GD) and Generalized Gaussian Distribution (GGD) NLoS detection algorithms. By employing our detection algorithm for the imbalanced dataset, a classification accuracy of $96.7\%$ and $98.0\%$ can be achieved. We also compared the proposed algorithm with the existing cutting-edge such as Support-Vector-Machine (SVM), Decision Tree (DT), Naive Bayes (NB), and Neural Network (NN), which can achieve an accuracy of $92.6\%$, $92.8\%$, $93.2\%$, and $95.5\%$, respectively. The results demonstrate that the GGD algorithm can achieve high classification accuracy with the imbalanced dataset. Finally, the proposed algorithm can also achieve a higher classification accuracy for different ratios of LoS and NLoS signals which proves the robustness and effectiveness of the proposed method.
Published: 2023
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14. A genetic history of the Balkans from Roman frontier to Slavic migrations

Author: Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Ministerio de Ciencia e Innovación (España), Fundación la Caixa, Natural Sciences and Engineering Research Council of Canada, Ministry of Science, Education and Sports of the Republic of Croatia, National Institutes of Health (US), John Templeton Foundation, Paul G. Allen Family Foundation, Howard Hughes Medical Institute, Olalde, Iñigo [0000-0002-2660-6807], Lalueza-Fox, Carles [0000-0002-1730-5914], Olalde, Iñigo, Carrión, Pablo, Mikić, Ilija, Rohland, Nadin, Mallick, Swapan, Lazaridis, Iosif, Mah, Matthew, Miomir Korać, Golubović, Snežana, Petković, Sofija, Miladinović-Radmilović, Nataša, Vulović, Dragana, Alihodžić, Timka, Ash, Abigail, Baeta, Miriam, Bartík, Juraj, Bedić, Željka, Bilić, Maja, Bonsall, Clive, Bunčić, Maja, Bužanić, Domagoj, Carić, Mario, Čataj, Lea, Cvetko, Mirna, Drnić, Ivan, Dugonjić, Anita, Đukić, Ana, Đukić, Ksenija, Farkaš, Zdeněk, Jelínek, Pavol, Jovanovic, Marija, Kaić, Iva, Kalafatić, Hrvoje, Krmpotić, Marijana, Krznar, Siniša, Leleković, Tino, Pancorbo, Marian M. de, Matijević, Vinka, Milošević Zakić, Branka, Osterholtz, Anna J., Paige, Julianne M., Tresić Pavičić, Dinko, Premužić, Zrinka, Rajić Šikanjić, Petra, Rapan Papeša, Anita, Paraman, Lujana, Sanader, Mirjana, Radovanović, Ivana, Roksandic, Mirjana, Šefčáková, Alena, Stefanović, Sofia, Teschler-Nicola, Maria, Tončinić, Domagoj, Zagorc, Brina, Callan, Kim, Candilio, Francesca, Cheronet, Olivia, Fernandes, Daniel, Kearns, Aisling, Lawson, Ann Marie, Mandl, Kirsten, Wagner, Anna, Zalzala, Fatma, Zettl, Anna, Tomanović, Željko, Keckarević, Dušan, Novak, Mario, Harper, Kyle, McCormick, Michael, Pinhasi, Ron, Grbić, Miodrag, Lalueza-Fox, Carles, Reich, David, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Ministerio de Ciencia e Innovación (España), Fundación la Caixa, Natural Sciences and Engineering Research Council of Canada, Ministry of Science, Education and Sports of the Republic of Croatia, National Institutes of Health (US), John Templeton Foundation, Paul G. Allen Family Foundation, Howard Hughes Medical Institute, Olalde, Iñigo [0000-0002-2660-6807], Lalueza-Fox, Carles [0000-0002-1730-5914], Olalde, Iñigo, Carrión, Pablo, Mikić, Ilija, Rohland, Nadin, Mallick, Swapan, Lazaridis, Iosif, Mah, Matthew, Miomir Korać, Golubović, Snežana, Petković, Sofija, Miladinović-Radmilović, Nataša, Vulović, Dragana, Alihodžić, Timka, Ash, Abigail, Baeta, Miriam, Bartík, Juraj, Bedić, Željka, Bilić, Maja, Bonsall, Clive, Bunčić, Maja, Bužanić, Domagoj, Carić, Mario, Čataj, Lea, Cvetko, Mirna, Drnić, Ivan, Dugonjić, Anita, Đukić, Ana, Đukić, Ksenija, Farkaš, Zdeněk, Jelínek, Pavol, Jovanovic, Marija, Kaić, Iva, Kalafatić, Hrvoje, Krmpotić, Marijana, Krznar, Siniša, Leleković, Tino, Pancorbo, Marian M. de, Matijević, Vinka, Milošević Zakić, Branka, Osterholtz, Anna J., Paige, Julianne M., Tresić Pavičić, Dinko, Premužić, Zrinka, Rajić Šikanjić, Petra, Rapan Papeša, Anita, Paraman, Lujana, Sanader, Mirjana, Radovanović, Ivana, Roksandic, Mirjana, Šefčáková, Alena, Stefanović, Sofia, Teschler-Nicola, Maria, Tončinić, Domagoj, Zagorc, Brina, Callan, Kim, Candilio, Francesca, Cheronet, Olivia, Fernandes, Daniel, Kearns, Aisling, Lawson, Ann Marie, Mandl, Kirsten, Wagner, Anna, Zalzala, Fatma, Zettl, Anna, Tomanović, Željko, Keckarević, Dušan, Novak, Mario, Harper, Kyle, McCormick, Michael, Pinhasi, Ron, Grbić, Miodrag, Lalueza-Fox, Carles, and Reich, David
Abstract: [Summary] The rise and fall of the Roman Empire was a socio-political process with enormous ramifications for human history. The Middle Danube was a crucial frontier and a crossroads for population and cultural movement. Here, we present genome-wide data from 136 Balkan individuals dated to the 1st millennium CE. Despite extensive militarization and cultural influence, we find little ancestry contribution from peoples of Italic descent. However, we trace a large-scale influx of people of Anatolian ancestry during the Imperial period. Between ∼250 and 550 CE, we detect migrants with ancestry from Central/Northern Europe and the Steppe, confirming that “barbarian” migrations were propelled by ethnically diverse confederations. Following the end of Roman control, we detect the large-scale arrival of individuals who were genetically similar to modern Eastern European Slavic-speaking populations, who contributed 30%–60% of the ancestry of Balkan people, representing one of the largest permanent demographic changes anywhere in Europe during the Migration Period.
Published: 2023

15. The importance of microvascular inflammation in ageing and age-related diseases: a position paper from the ESH working group on small arteries, section of microvascular inflammation

Author: Mengozzi, Alessandro; https://orcid.org/0000-0003-2834-9725, de Ciuceis, Carolina, Dell'oro, Raffaella, Georgiopoulos, Georgios; https://orcid.org/0000-0001-7661-5253, Lazaridis, Antonios, Nosalski, Ryszard, Pavlidis, George, Tual-Chalot, Simon, Agabiti-Rosei, Claudia, Anyfanti, Panagiota, Camargo, Livia L, Dąbrowska, Edyta, Quarti-Trevano, Fosca, Hellmann, Marcin, Masi, Stefano; https://orcid.org/0000-0002-7591-3686, Mavraganis, Georgios, Montezano, Augusto C, Rios, Francesco J, Winklewski, Pawel J, Wolf, Jacek, Costantino, Sarah; https://orcid.org/0000-0002-3003-7213, Gkaliagkousi, Eugenia, Grassi, Guido, Guzik, Tomasz J; https://orcid.org/0000-0003-2012-1187, Ikonomidis, Ignatios, Narkiewicz, Krzysztof, Paneni, Francesco; https://orcid.org/0000-0001-6483-7844, Rizzoni, Damiano, Stamatelopoulos, Kimon, Stellos, Konstantinos; https://orcid.org/0000-0002-0194-0825, et al, Mengozzi, Alessandro; https://orcid.org/0000-0003-2834-9725, de Ciuceis, Carolina, Dell'oro, Raffaella, Georgiopoulos, Georgios; https://orcid.org/0000-0001-7661-5253, Lazaridis, Antonios, Nosalski, Ryszard, Pavlidis, George, Tual-Chalot, Simon, Agabiti-Rosei, Claudia, Anyfanti, Panagiota, Camargo, Livia L, Dąbrowska, Edyta, Quarti-Trevano, Fosca, Hellmann, Marcin, Masi, Stefano; https://orcid.org/0000-0002-7591-3686, Mavraganis, Georgios, Montezano, Augusto C, Rios, Francesco J, Winklewski, Pawel J, Wolf, Jacek, Costantino, Sarah; https://orcid.org/0000-0002-3003-7213, Gkaliagkousi, Eugenia, Grassi, Guido, Guzik, Tomasz J; https://orcid.org/0000-0003-2012-1187, Ikonomidis, Ignatios, Narkiewicz, Krzysztof, Paneni, Francesco; https://orcid.org/0000-0001-6483-7844, Rizzoni, Damiano, Stamatelopoulos, Kimon, Stellos, Konstantinos; https://orcid.org/0000-0002-0194-0825, and et al
Abstract: Microcirculation is pervasive and orchestrates a profound regulatory cross-talk with the surrounding tissue and organs. Similarly, it is one of the earliest biological systems targeted by environmental stressors and consequently involved in the development and progression of ageing and age-related disease. Microvascular dysfunction, if not targeted, leads to a steady derangement of the phenotype, which cumulates comorbidities and eventually results in a nonrescuable, very high-cardiovascular risk. Along the broad spectrum of pathologies, both shared and distinct molecular pathways and pathophysiological alteration are involved in the disruption of microvascular homeostasis, all pointing to microvascular inflammation as the putative primary culprit. This position paper explores the presence and the detrimental contribution of microvascular inflammation across the whole spectrum of chronic age-related diseases, which characterise the 21st-century healthcare landscape. The manuscript aims to strongly affirm the centrality of microvascular inflammation by recapitulating the current evidence and providing a clear synoptic view of the whole cardiometabolic derangement. Indeed, there is an urgent need for further mechanistic exploration to identify clear, very early or disease-specific molecular targets to provide an effective therapeutic strategy against the otherwise unstoppable rising prevalence of age-related diseases.
Published: 2023

16. Deep Phenotyping of Non-Alcoholic Fatty Liver Disease Patients with Genetic Factors for Insights into the Complex Disease

Author: Priya, Tahmina Sultana, Leng, Fan, Luehrs, Anthony C., Klee, Eric W., Allen, Alina M., Lazaridis, Konstantinos N., Danfeng, Yao, Tian, Shulan, Priya, Tahmina Sultana, Leng, Fan, Luehrs, Anthony C., Klee, Eric W., Allen, Alina M., Lazaridis, Konstantinos N., Danfeng, Yao, and Tian, Shulan
Abstract: Non-alcoholic fatty liver disease (NAFLD) is a prevalent chronic liver disorder characterized by the excessive accumulation of fat in the liver in individuals who do not consume significant amounts of alcohol, including risk factors like obesity, insulin resistance, type 2 diabetes, etc. We aim to identify subgroups of NAFLD patients based on demographic, clinical, and genetic characteristics for precision medicine. The genomic and phenotypic data (3,408 cases and 4,739 controls) for this study were gathered from participants in Mayo Clinic Tapestry Study (IRB#19-000001) and their electric health records, including their demographic, clinical, and comorbidity data, and the genotype information through whole exome sequencing performed at Helix using the Exome+$^\circledR$ Assay according to standard procedure (www$.$helix$.$com). Factors highly relevant to NAFLD were determined by the chi-square test and stepwise backward-forward regression model. Latent class analysis (LCA) was performed on NAFLD cases using significant indicator variables to identify subgroups. The optimal clustering revealed 5 latent subgroups from 2,013 NAFLD patients (mean age 60.6 years and 62.1% women), while a polygenic risk score based on 6 single-nucleotide polymorphism (SNP) variants and disease outcomes were used to analyze the subgroups. The groups are characterized by metabolic syndrome, obesity, different comorbidities, psychoneurological factors, and genetic factors. Odds ratios were utilized to compare the risk of complex diseases, such as fibrosis, cirrhosis, and hepatocellular carcinoma (HCC), as well as liver failure between the clusters. Cluster 2 has a significantly higher complex disease outcome compared to other clusters. Keywords: Fatty liver disease; Polygenic risk score; Precision medicine; Deep phenotyping; NAFLD comorbidities; Latent class analysis., Comment: Extended Abstract presented at Machine Learning for Health (ML4H) symposium 2023, December 10th, 2023, New Orleans, United States, 11 pages
Published: 2023

17. REMEDI: REinforcement learning-driven adaptive MEtabolism modeling of primary sclerosing cholangitis DIsease progression

Author: Hu, Chang, Saboo, Krishnakant V., Ali, Ahmad H., Juran, Brian D., Lazaridis, Konstantinos N., Iyer, Ravishankar K., Hu, Chang, Saboo, Krishnakant V., Ali, Ahmad H., Juran, Brian D., Lazaridis, Konstantinos N., and Iyer, Ravishankar K.
Abstract: Primary sclerosing cholangitis (PSC) is a rare disease wherein altered bile acid metabolism contributes to sustained liver injury. This paper introduces REMEDI, a framework that captures bile acid dynamics and the body's adaptive response during PSC progression that can assist in exploring treatments. REMEDI merges a differential equation (DE)-based mechanistic model that describes bile acid metabolism with reinforcement learning (RL) to emulate the body's adaptations to PSC continuously. An objective of adaptation is to maintain homeostasis by regulating enzymes involved in bile acid metabolism. These enzymes correspond to the parameters of the DEs. REMEDI leverages RL to approximate adaptations in PSC, treating homeostasis as a reward signal and the adjustment of the DE parameters as the corresponding actions. On real-world data, REMEDI generated bile acid dynamics and parameter adjustments consistent with published findings. Also, our results support discussions in the literature that early administration of drugs that suppress bile acid synthesis may be effective in PSC treatment., Comment: 8 pages, 5 figures, 4 appendices
Published: 2023

18. X Chromosome Contribution to the Genetic Architecture of Primary Biliary Cholangitis

Author: Asselta, R, Paraboschi, E, Gerussi, A, Cordell, H, Mells, G, Sandford, R, Jones, D, Nakamura, M, Ueno, K, Hitomi, Y, Kawashima, M, Nishida, N, Tokunaga, K, Nagasaki, M, Tanaka, A, Tang, R, Li, Z, Shi, Y, Liu, X, Xiong, M, Hirschfield, G, Siminovitch, K, Walker, E, Xie, G, Mason, A, Myers, R, Peltekian, K, Ghent, C, Atkinson, E, Juran, B, Lazaridis, K, Lu, Y, Gu, X, Jing, K, Amos, C, Affronti, A, Brunetto, M, Coco, B, Spinzi, G, Elia, G, Ferrari, C, Lleo, A, Muratori, L, Muratori, P, Portincasa, P, Colli, A, Bruno, S, Colloredo, G, Azzaroli, F, Andreone, P, Bragazzi, M, Alvaro, D, Cardinale, V, Cazzagon, N, Rigamonti, C, Floreani, A, Rosina, F, Ciaccio, A, Cristoferi, L, D'Amato, D, Malinverno, F, Mancuso, C, Massironi, S, Milani, C, O'Donnell, S, Ronca, V, Barisani, D, Lampertico, P, Donato, F, Fagiuoli, S, Almasio, P, Giannini, E, Cursaro, C, Colombo, M, Valenti, L, Miele, L, Andriulli, A, Niro, G, Grattagliano, I, Morini, L, Casella, G, Vinci, M, Battezzati, P, Crosignani, A, Zuin, M, Mattalia, A, Calvaruso, V, Colombo, S, Benedetti, A, Marzioni, M, Galli, A, Marra, F, Tarocchi, M, Picciotto, A, Morisco, F, Fabris, L, Croce, L, Tiribelli, C, Toniutto, P, Strazzabosco, M, Ch'Ng, C, Rahman, M, Yapp, T, Sturgess, R, Healey, C, Czajkowski, M, Gunasekera, A, Gyawali, P, Premchand, P, Kapur, K, Marley, R, Foster, G, Watson, A, Dias, A, Subhani, J, Harvey, R, Mccorry, R, Ramanaden, D, Gasem, J, Evans, R, Mathialahan, T, Shorrock, C, Lipscomb, G, Southern, P, Tibble, J, Gorard, D, Palegwala, A, Jones, S, Dawwas, M, Alexander, G, Dolwani, S, Prince, M, Foxton, M, Elphick, D, Mitchison, H, Gooding, I, Karmo, M, Saksena, S, Mendall, M, Patel, M, Ede, R, Austin, A, Sayer, J, Hankey, L, Hovell, C, Fisher, N, Carter, M, Koss, K, Piotrowicz, A, Grimley, C, Neal, D, Lim, G, Levi, S, Ala, A, Broad, A, Saeed, A, Wood, G, Brown, J, Wilkinson, M, Gordon, H, Ramage, J, Ridpath, J, Ngatchu, T, Grover, B, Shaukat, S, Shidrawi, R, Abouda, G, Ali, F, Rees, I, Salam, I, Narain, M, Brown, A, Taylor-Robinson, S, Williams, S, Grellier, L, Banim, P, Das, D, Chilton, A, Heneghan, M, Curtis, H, Gess, M, Drake, I, Aldersley, M, Davies, M, Jones, R, Mcnair, A, Srirajaskanthan, R, Pitcher, M, Sen, S, Bird, G, Barnardo, A, Kitchen, P, Yoong, K, Chirag, O, Sivaramakrishnan, N, Macfaul, G, Shah, A, Evans, C, Saha, S, Pollock, K, Bramley, P, Mukhopadhya, A, Fraser, A, Mills, P, Shallcross, C, Campbell, S, Bathgate, A, Shepherd, A, Dillon, J, Rushbrook, S, Przemioslo, R, Macdonald, C, Metcalf, J, Shmueli, U, Davis, A, Naqvi, A, Lee, T, Ryder, S, Collier, J, Klass, H, Ninkovic, M, Cramp, M, Sharer, N, Aspinall, R, Goggin, P, Ghosh, D, Douds, A, Hoeroldt, B, Booth, J, Williams, E, Hussaini, H, Stableforth, W, Ayres, R, Thorburn, D, Marshall, E, Burroughs, A, Mann, S, Lombard, M, Richardson, P, Patanwala, I, Maltby, J, Brookes, M, Mathew, R, Vyas, S, Singhal, S, Gleeson, D, Misra, S, Butterworth, J, George, K, Harding, T, Douglass, A, Panter, S, Shearman, J, Bray, G, Butcher, G, Forton, D, Mclindon, J, Cowan, M, Whatley, G, Mandal, A, Gupta, H, Sanghi, P, Jain, S, Pereira, S, Prasad, G, Watts, G, Wright, M, Neuberger, J, Gordon, F, Unitt, E, Grant, A, Delahooke, T, Higham, A, Brind, A, Cox, M, Ramakrishnan, S, King, A, Collins, C, Whalley, S, Li, A, Fraser, J, Bell, A, Wong, V, Singhal, A, Gee, I, Ang, Y, Ransford, R, Gotto, J, Millson, C, Bowles, J, Thomas, C, Harrison, M, Galaska, R, Kendall, J, Whiteman, J, Lawlor, C, Gray, C, Elliott, K, Mulvaney-Jones, C, Hobson, L, Van Duyvenvoorde, G, Loftus, A, Seward, K, Penn, R, Maiden, J, Damant, R, Hails, J, Cloudsdale, R, Silvestre, V, Glenn, S, Dungca, E, Wheatley, N, Doyle, H, Kent, M, Hamilton, C, Braim, D, Wooldridge, H, Abrahams, R, Paton, A, Lancaster, N, Gibbins, A, Hogben, K, Desousa, P, Muscariu, F, Musselwhite, J, Mckay, A, Tan, L, Foale, C, Brighton, J, Flahive, K, Nambela, E, Townshend, P, Ford, C, Holder, S, Palmer, C, Featherstone, J, Nasseri, M, Sadeghian, J, Williams, B, Rolls, S, Hynes, A, Duggan, C, Crossey, M, Stansfield, G, Macnicol, C, Wilkins, J, Wilhelmsen, E, Raymode, P, Lee, H, Durant, E, Bishop, R, Ncube, N, Tripoli, S, Casey, R, Cowley, C, Miller, R, Houghton, K, Ducker, S, Wright, F, Bird, B, Baxter, G, Keggans, J, Hughes, M, Grieve, E, Young, K, Williams, D, Ocker, K, Hines, F, Martin, K, Innes, C, Valliani, T, Fairlamb, H, Thornthwaite, S, Eastick, A, Tanqueray, E, Morrison, J, Holbrook, B, Browning, J, Walker, K, Congreave, S, Verheyden, J, Slininger, S, Stafford, L, O'Donnell, D, Ainsworth, M, Lord, S, Kent, L, March, L, Dickson, C, Simpson, D, Longhurst, B, Hayes, M, Shpuza, E, White, N, Besley, S, Pearson, S, Wright, A, Jones, L, Gunter, E, Dewhurst, H, Fouracres, A, Farrington, L, Graves, L, Marriott, S, Leoni, M, Tyrer, D, Dali-kemmery, L, Lambourne, V, Green, M, Sirdefield, D, Amor, K, Colley, J, Shinder, B, Jones, J, Mills, M, Carnahan, M, Taylor, N, Boulton, K, Tregonning, J, Brown, C, Clifford, G, Archer, E, Hamilton, M, Curtis, J, Shewan, T, Walsh, S, Warner, K, Netherton, K, Mupudzi, M, Gunson, B, Gitahi, J, Gocher, D, Batham, S, Pateman, H, Desmennu, S, Conder, J, Clement, D, Gallagher, S, Orpe, J, Chan, P, Currie, L, O'Donohoe, L, Oblak, M, Morgan, L, Quinn, M, Amey, I, Baird, Y, Cotterill, D, Cumlat, L, Winter, L, Greer, S, Spurdle, K, Allison, J, Dyer, S, Sweeting, H, Kordula, J, Aiba, Y, Nakamura, H, Abiru, S, Nagaoka, S, Komori, A, Yatsuhashi, H, Ishibashi, H, Ito, M, Kawai, Y, Kohn, S, Gervais, O, Migita, K, Katsushima, S, Naganuma, A, Sugi, K, Komatsu, T, Mannami, T, Matsushita, K, Yoshizawa, K, Makita, F, Nikami, T, Nishimura, H, Kouno, H, Ota, H, Komura, T, Nakamura, Y, Shimada, M, Hirashima, N, Komeda, T, Ario, K, Nakamuta, M, Yamashita, T, Furuta, K, Kikuchi, M, Naeshiro, N, Takahashi, H, Mano, Y, Tsunematsu, S, Yabuuchi, I, Shimada, Y, Yamauchi, K, Sugimoto, R, Sakai, H, Mita, E, Koda, M, Tsuruta, S, Kamitsukasa, H, Sato, T, Masaki, N, Kobata, T, Fukushima, N, Higuchi, N, Ohara, Y, Muro, T, Takesaki, E, Takaki, H, Yamamoto, T, Kato, M, Nagaoki, Y, Hayashi, S, Ishida, J, Watanabe, Y, Kobayashi, M, Koga, M, Saoshiro, T, Yagura, M, Hirata, K, Takikawa, H, Ohira, H, Zeniya, M, Abe, M, Onji, M, Kaneko, S, Honda, M, Arai, K, Arinaga-Hino, T, Hashimoto, E, Taniai, M, Umemura, T, Joshita, S, Nakao, K, Ichikawa, T, Shibata, H, Yamagiwa, S, Seike, M, Honda, K, Sakisaka, S, Takeyama, Y, Harada, M, Senju, M, Yokosuka, O, Kanda, T, Ueno, Y, Kikuchi, K, Ebinuma, H, Himoto, T, Yasunami, M, Murata, K, Mizokami, M, Shimoda, S, Miyake, Y, Takaki, A, Yamamoto, K, Hirano, K, Ichida, T, Ido, A, Tsubouchi, H, Chayama, K, Harada, K, Nakanuma, Y, Maehara, Y, Taketomi, A, Shirabe, K, Soejima, Y, Mori, A, Yagi, S, Uemoto, S, Tanaka, T, Yamashiki, N, Tamura, S, Sugawara, Y, Kokudo, N, Carbone, M, Cardamone, G, Duga, S, Gershwin, M, Seldin, M, Invernizzi, P, Asselta R., Paraboschi E. M., Gerussi A., Cordell H. J., Mells G. F., Sandford R. N., Jones D. E., Nakamura M., Ueno K., Hitomi Y., Kawashima M., Nishida N., Tokunaga K., Nagasaki M., Tanaka A., Tang R., Li Z., Shi Y., Liu X., Xiong M., Hirschfield G., Siminovitch K. A., Walker E., Xie G., Mason A., Myers R., Peltekian K., Ghent C., Atkinson E., Juran B., Lazaridis K., Lu Y., Gu X., Jing K., Amos C., Affronti A., Brunetto M., Coco B., Spinzi G., Elia G., Ferrari C., Lleo A., Muratori L., Muratori P., Portincasa P., Colli A., Bruno S., Colloredo G., Azzaroli F., Andreone P., Bragazzi M., Alvaro D., Cardinale V., Cazzagon N., Rigamonti C., Floreani A., Rosina F., Ciaccio A., Cristoferi L., D'Amato D., Malinverno F., Mancuso C., Massironi S., Milani C., O'Donnell S. E., Ronca V., Barisani D., Lampertico P., Donato F., Fagiuoli S., Almasio P. L., Giannini E., Cursaro C., Colombo M., Valenti L., Miele L., Andriulli A., Niro G. A., Grattagliano I., Morini L., Casella G., Vinci M., Battezzati P. M., Crosignani A., Zuin M., Mattalia A., Calvaruso V., Colombo S., Benedetti A., Marzioni M., Galli A., Marra F., Tarocchi M., Picciotto A., Morisco F., Fabris L., Croce L. S., Tiribelli C., Toniutto P., Strazzabosco M., Ch'ng C. L., Rahman M., Yapp T., Sturgess R., Healey C., Czajkowski M., Gunasekera A., Gyawali P., Premchand P., Kapur K., Marley R., Foster G., Watson A., Dias A., Subhani J., Harvey R., McCorry R., Ramanaden D., Gasem J., Evans R., Mathialahan T., Shorrock C., Lipscomb G., Southern P., Tibble J., Gorard D., Palegwala A., Jones S., Dawwas M., Alexander G., Dolwani S., Prince M., Foxton M., Elphick D., Mitchison H., Gooding I., Karmo M., Saksena S., Mendall M., Patel M., Ede R., Austin A., Sayer J., Hankey L., Hovell C., Fisher N., Carter M., Koss K., Piotrowicz A., Grimley C., Neal D., Lim G., Levi S., Ala A., Broad A., Saeed A., Wood G., Brown J., Wilkinson M., Gordon H., Ramage J., Ridpath J., Ngatchu T., Grover B., Shaukat S., Shidrawi R., Abouda G., Ali F., Rees I., Salam I., Narain M., Brown A., Taylor-Robinson S., Williams S., Grellier L., Banim P., Das D., Chilton A., Heneghan M., Curtis H., Gess M., Drake I., Aldersley M., Davies M., Jones R., McNair A., Srirajaskanthan R., Pitcher M., Sen S., Bird G., Barnardo A., Kitchen P., Yoong K., Chirag O., Sivaramakrishnan N., MacFaul G., Jones D., Shah A., Evans C., Saha S., Pollock K., Bramley P., Mukhopadhya A., Fraser A., Mills P., Shallcross C., Campbell S., Bathgate A., Shepherd A., Dillon J., Rushbrook S., Przemioslo R., Macdonald C., Metcalf J., Shmueli U., Davis A., Naqvi A., Lee T., Ryder S. D., Collier J., Klass H., Ninkovic M., Cramp M., Sharer N., Aspinall R., Goggin P., Ghosh D., Douds A., Hoeroldt B., Booth J., Williams E., Hussaini H., Stableforth W., Ayres R., Thorburn D., Marshall E., Burroughs A., Mann S., Lombard M., Richardson P., Patanwala I., Maltby J., Brookes M., Mathew R., Vyas S., Singhal S., Gleeson D., Misra S., Butterworth J., George K., Harding T., Douglass A., Panter S., Shearman J., Bray G., Butcher G., Forton D., Mclindon J., Cowan M., Whatley G., Mandal A., Gupta H., Sanghi P., Jain S., Pereira S., Prasad G., Watts G., Wright M., Neuberger J., Gordon F., Unitt E., Grant A., Delahooke T., Higham A., Brind A., Cox M., Ramakrishnan S., King A., Collins C., Whalley S., Li A., Fraser J., Bell A., Wong V. S., Singhal A., Gee I., Ang Y., Ransford R., Gotto J., Millson C., Bowles J., Thomas C., Harrison M., Galaska R., Kendall J., Whiteman J., Lawlor C., Gray C., Elliott K., Mulvaney-Jones C., Hobson L., Van Duyvenvoorde G., Loftus A., Seward K., Penn R., Maiden J., Damant R., Hails J., Cloudsdale R., Silvestre V., Glenn S., Dungca E., Wheatley N., Doyle H., Kent M., Hamilton C., Braim D., Wooldridge H., Abrahams R., Paton A., Lancaster N., Gibbins A., Hogben K., Desousa P., Muscariu F., Musselwhite J., McKay A., Tan L., Foale C., Brighton J., Flahive K., Nambela E., Townshend P., Ford C., Holder S., Palmer C., Featherstone J., Nasseri M., Sadeghian J., Williams B., Rolls S. -A., Hynes A., Duggan C., Crossey M., Stansfield G., MacNicol C., Wilkins J., Wilhelmsen E., Raymode P., Lee H. -J., Durant E., Bishop R., Ncube N., Tripoli S., Casey R., Cowley C., Miller R., Houghton K., Ducker S., Wright F., Bird B., Baxter G., Keggans J., Hughes M., Grieve E., Young K., Williams D., Ocker K., Hines F., Martin K., Innes C., Valliani T., Fairlamb H., Thornthwaite S., Eastick A., Tanqueray E., Morrison J., Holbrook B., Browning J., Walker K., Congreave S., Verheyden J., Slininger S., Stafford L., O'Donnell D., Ainsworth M., Lord S., Kent L., March L., Dickson C., Simpson D., Longhurst B., Hayes M., Shpuza E., White N., Besley S., Pearson S., Wright A., Jones L., Gunter E., Dewhurst H., Fouracres A., Farrington L., Graves L., Marriott S., Leoni M., Tyrer D., Dali-kemmery L., Lambourne V., Green M., Sirdefield D., Amor K., Colley J., Shinder B., Jones J., Mills M., Carnahan M., Taylor N., Boulton K., Tregonning J., Brown C., Clifford G., Archer E., Hamilton M., Curtis J., Shewan T., Walsh S., Warner K., Netherton K., Mupudzi M., Gunson B., Gitahi J., Gocher D., Batham S., Pateman H., Desmennu S., Conder J., Clement D., Gallagher S., Orpe J., Chan P., Currie L., O'Donohoe L., Oblak M., Morgan L., Quinn M., Amey I., Baird Y., Cotterill D., Cumlat L., Winter L., Greer S., Spurdle K., Allison J., Dyer S., Sweeting H., Kordula J., Aiba Y., Nakamura H., Abiru S., Nagaoka S., Komori A., Yatsuhashi H., Ishibashi H., Ito M., Kawai Y., Kohn S. -S., Gervais O., Migita K., Katsushima S., Naganuma A., Sugi K., Komatsu T., Mannami T., Matsushita K., Yoshizawa K., Makita F., Nikami T., Nishimura H., Kouno H., Ota H., Komura T., Nakamura Y., Shimada M., Hirashima N., Komeda T., Ario K., Nakamuta M., Yamashita T., Furuta K., Kikuchi M., Naeshiro N., Takahashi H., Mano Y., Tsunematsu S., Yabuuchi I., Shimada Y., Yamauchi K., Sugimoto R., Sakai H., Mita E., Koda M., Tsuruta S., Kamitsukasa H., Sato T., Masaki N., Kobata T., Fukushima N., Higuchi N., Ohara Y., Muro T., Takesaki E., Takaki H., Yamamoto T., Kato M., Nagaoki Y., Hayashi S., Ishida J., Watanabe Y., Kobayashi M., Koga M., Saoshiro T., Yagura M., Hirata K., Takikawa H., Ohira H., Zeniya M., Abe M., Onji M., Kaneko S., Honda M., Arai K., Arinaga-Hino T., Hashimoto E., Taniai M., Umemura T., Joshita S., Nakao K., Ichikawa T., Shibata H., Yamagiwa S., Seike M., Honda K., Sakisaka S., Takeyama Y., Harada M., Senju M., Yokosuka O., Kanda T., Ueno Y., Kikuchi K., Ebinuma H., Himoto T., Yasunami M., Murata K., Mizokami M., Shimoda S., Miyake Y., Takaki A., Yamamoto K., Hirano K., Ichida T., Ido A., Tsubouchi H., Chayama K., Harada K., Nakanuma Y., Maehara Y., Taketomi A., Shirabe K., Soejima Y., Mori A., Yagi S., Uemoto S., Tanaka T., Yamashiki N., Tamura S., Sugawara Y., Kokudo N., Carbone M., Cardamone G., Duga S., Gershwin M. E., Seldin M. F., Invernizzi P., Asselta, R, Paraboschi, E, Gerussi, A, Cordell, H, Mells, G, Sandford, R, Jones, D, Nakamura, M, Ueno, K, Hitomi, Y, Kawashima, M, Nishida, N, Tokunaga, K, Nagasaki, M, Tanaka, A, Tang, R, Li, Z, Shi, Y, Liu, X, Xiong, M, Hirschfield, G, Siminovitch, K, Walker, E, Xie, G, Mason, A, Myers, R, Peltekian, K, Ghent, C, Atkinson, E, Juran, B, Lazaridis, K, Lu, Y, Gu, X, Jing, K, Amos, C, Affronti, A, Brunetto, M, Coco, B, Spinzi, G, Elia, G, Ferrari, C, Lleo, A, Muratori, L, Muratori, P, Portincasa, P, Colli, A, Bruno, S, Colloredo, G, Azzaroli, F, Andreone, P, Bragazzi, M, Alvaro, D, Cardinale, V, Cazzagon, N, Rigamonti, C, Floreani, A, Rosina, F, Ciaccio, A, Cristoferi, L, D'Amato, D, Malinverno, F, Mancuso, C, Massironi, S, Milani, C, O'Donnell, S, Ronca, V, Barisani, D, Lampertico, P, Donato, F, Fagiuoli, S, Almasio, P, Giannini, E, Cursaro, C, Colombo, M, Valenti, L, Miele, L, Andriulli, A, Niro, G, Grattagliano, I, Morini, L, Casella, G, Vinci, M, Battezzati, P, Crosignani, A, Zuin, M, Mattalia, A, Calvaruso, V, Colombo, S, Benedetti, A, Marzioni, M, Galli, A, Marra, F, Tarocchi, M, Picciotto, A, Morisco, F, Fabris, L, Croce, L, Tiribelli, C, Toniutto, P, Strazzabosco, M, Ch'Ng, C, Rahman, M, Yapp, T, Sturgess, R, Healey, C, Czajkowski, M, Gunasekera, A, Gyawali, P, Premchand, P, Kapur, K, Marley, R, Foster, G, Watson, A, Dias, A, Subhani, J, Harvey, R, Mccorry, R, Ramanaden, D, Gasem, J, Evans, R, Mathialahan, T, Shorrock, C, Lipscomb, G, Southern, P, Tibble, J, Gorard, D, Palegwala, A, Jones, S, Dawwas, M, Alexander, G, Dolwani, S, Prince, M, Foxton, M, Elphick, D, Mitchison, H, Gooding, I, Karmo, M, Saksena, S, Mendall, M, Patel, M, Ede, R, Austin, A, Sayer, J, Hankey, L, Hovell, C, Fisher, N, Carter, M, Koss, K, Piotrowicz, A, Grimley, C, Neal, D, Lim, G, Levi, S, Ala, A, Broad, A, Saeed, A, Wood, G, Brown, J, Wilkinson, M, Gordon, H, Ramage, J, Ridpath, J, Ngatchu, T, Grover, B, Shaukat, S, Shidrawi, R, Abouda, G, Ali, F, Rees, I, Salam, I, Narain, M, Brown, A, Taylor-Robinson, S, Williams, S, Grellier, L, Banim, P, Das, D, Chilton, A, Heneghan, M, Curtis, H, Gess, M, Drake, I, Aldersley, M, Davies, M, Jones, R, Mcnair, A, Srirajaskanthan, R, Pitcher, M, Sen, S, Bird, G, Barnardo, A, Kitchen, P, Yoong, K, Chirag, O, Sivaramakrishnan, N, Macfaul, G, Shah, A, Evans, C, Saha, S, Pollock, K, Bramley, P, Mukhopadhya, A, Fraser, A, Mills, P, Shallcross, C, Campbell, S, Bathgate, A, Shepherd, A, Dillon, J, Rushbrook, S, Przemioslo, R, Macdonald, C, Metcalf, J, Shmueli, U, Davis, A, Naqvi, A, Lee, T, Ryder, S, Collier, J, Klass, H, Ninkovic, M, Cramp, M, Sharer, N, Aspinall, R, Goggin, P, Ghosh, D, Douds, A, Hoeroldt, B, Booth, J, Williams, E, Hussaini, H, Stableforth, W, Ayres, R, Thorburn, D, Marshall, E, Burroughs, A, Mann, S, Lombard, M, Richardson, P, Patanwala, I, Maltby, J, Brookes, M, Mathew, R, Vyas, S, Singhal, S, Gleeson, D, Misra, S, Butterworth, J, George, K, Harding, T, Douglass, A, Panter, S, Shearman, J, Bray, G, Butcher, G, Forton, D, Mclindon, J, Cowan, M, Whatley, G, Mandal, A, Gupta, H, Sanghi, P, Jain, S, Pereira, S, Prasad, G, Watts, G, Wright, M, Neuberger, J, Gordon, F, Unitt, E, Grant, A, Delahooke, T, Higham, A, Brind, A, Cox, M, Ramakrishnan, S, King, A, Collins, C, Whalley, S, Li, A, Fraser, J, Bell, A, Wong, V, Singhal, A, Gee, I, Ang, Y, Ransford, R, Gotto, J, Millson, C, Bowles, J, Thomas, C, Harrison, M, Galaska, R, Kendall, J, Whiteman, J, Lawlor, C, Gray, C, Elliott, K, Mulvaney-Jones, C, Hobson, L, Van Duyvenvoorde, G, Loftus, A, Seward, K, Penn, R, Maiden, J, Damant, R, Hails, J, Cloudsdale, R, Silvestre, V, Glenn, S, Dungca, E, Wheatley, N, Doyle, H, Kent, M, Hamilton, C, Braim, D, Wooldridge, H, Abrahams, R, Paton, A, Lancaster, N, Gibbins, A, Hogben, K, Desousa, P, Muscariu, F, Musselwhite, J, Mckay, A, Tan, L, Foale, C, Brighton, J, Flahive, K, Nambela, E, Townshend, P, Ford, C, Holder, S, Palmer, C, Featherstone, J, Nasseri, M, Sadeghian, J, Williams, B, Rolls, S, Hynes, A, Duggan, C, Crossey, M, Stansfield, G, Macnicol, C, Wilkins, J, Wilhelmsen, E, Raymode, P, Lee, H, Durant, E, Bishop, R, Ncube, N, Tripoli, S, Casey, R, Cowley, C, Miller, R, Houghton, K, Ducker, S, Wright, F, Bird, B, Baxter, G, Keggans, J, Hughes, M, Grieve, E, Young, K, Williams, D, Ocker, K, Hines, F, Martin, K, Innes, C, Valliani, T, Fairlamb, H, Thornthwaite, S, Eastick, A, Tanqueray, E, Morrison, J, Holbrook, B, Browning, J, Walker, K, Congreave, S, Verheyden, J, Slininger, S, Stafford, L, O'Donnell, D, Ainsworth, M, Lord, S, Kent, L, March, L, Dickson, C, Simpson, D, Longhurst, B, Hayes, M, Shpuza, E, White, N, Besley, S, Pearson, S, Wright, A, Jones, L, Gunter, E, Dewhurst, H, Fouracres, A, Farrington, L, Graves, L, Marriott, S, Leoni, M, Tyrer, D, Dali-kemmery, L, Lambourne, V, Green, M, Sirdefield, D, Amor, K, Colley, J, Shinder, B, Jones, J, Mills, M, Carnahan, M, Taylor, N, Boulton, K, Tregonning, J, Brown, C, Clifford, G, Archer, E, Hamilton, M, Curtis, J, Shewan, T, Walsh, S, Warner, K, Netherton, K, Mupudzi, M, Gunson, B, Gitahi, J, Gocher, D, Batham, S, Pateman, H, Desmennu, S, Conder, J, Clement, D, Gallagher, S, Orpe, J, Chan, P, Currie, L, O'Donohoe, L, Oblak, M, Morgan, L, Quinn, M, Amey, I, Baird, Y, Cotterill, D, Cumlat, L, Winter, L, Greer, S, Spurdle, K, Allison, J, Dyer, S, Sweeting, H, Kordula, J, Aiba, Y, Nakamura, H, Abiru, S, Nagaoka, S, Komori, A, Yatsuhashi, H, Ishibashi, H, Ito, M, Kawai, Y, Kohn, S, Gervais, O, Migita, K, Katsushima, S, Naganuma, A, Sugi, K, Komatsu, T, Mannami, T, Matsushita, K, Yoshizawa, K, Makita, F, Nikami, T, Nishimura, H, Kouno, H, Ota, H, Komura, T, Nakamura, Y, Shimada, M, Hirashima, N, Komeda, T, Ario, K, Nakamuta, M, Yamashita, T, Furuta, K, Kikuchi, M, Naeshiro, N, Takahashi, H, Mano, Y, Tsunematsu, S, Yabuuchi, I, Shimada, Y, Yamauchi, K, Sugimoto, R, Sakai, H, Mita, E, Koda, M, Tsuruta, S, Kamitsukasa, H, Sato, T, Masaki, N, Kobata, T, Fukushima, N, Higuchi, N, Ohara, Y, Muro, T, Takesaki, E, Takaki, H, Yamamoto, T, Kato, M, Nagaoki, Y, Hayashi, S, Ishida, J, Watanabe, Y, Kobayashi, M, Koga, M, Saoshiro, T, Yagura, M, Hirata, K, Takikawa, H, Ohira, H, Zeniya, M, Abe, M, Onji, M, Kaneko, S, Honda, M, Arai, K, Arinaga-Hino, T, Hashimoto, E, Taniai, M, Umemura, T, Joshita, S, Nakao, K, Ichikawa, T, Shibata, H, Yamagiwa, S, Seike, M, Honda, K, Sakisaka, S, Takeyama, Y, Harada, M, Senju, M, Yokosuka, O, Kanda, T, Ueno, Y, Kikuchi, K, Ebinuma, H, Himoto, T, Yasunami, M, Murata, K, Mizokami, M, Shimoda, S, Miyake, Y, Takaki, A, Yamamoto, K, Hirano, K, Ichida, T, Ido, A, Tsubouchi, H, Chayama, K, Harada, K, Nakanuma, Y, Maehara, Y, Taketomi, A, Shirabe, K, Soejima, Y, Mori, A, Yagi, S, Uemoto, S, Tanaka, T, Yamashiki, N, Tamura, S, Sugawara, Y, Kokudo, N, Carbone, M, Cardamone, G, Duga, S, Gershwin, M, Seldin, M, Invernizzi, P, Asselta R., Paraboschi E. M., Gerussi A., Cordell H. J., Mells G. F., Sandford R. N., Jones D. E., Nakamura M., Ueno K., Hitomi Y., Kawashima M., Nishida N., Tokunaga K., Nagasaki M., Tanaka A., Tang R., Li Z., Shi Y., Liu X., Xiong M., Hirschfield G., Siminovitch K. A., Walker E., Xie G., Mason A., Myers R., Peltekian K., Ghent C., Atkinson E., Juran B., Lazaridis K., Lu Y., Gu X., Jing K., Amos C., Affronti A., Brunetto M., Coco B., Spinzi G., Elia G., Ferrari C., Lleo A., Muratori L., Muratori P., Portincasa P., Colli A., Bruno S., Colloredo G., Azzaroli F., Andreone P., Bragazzi M., Alvaro D., Cardinale V., Cazzagon N., Rigamonti C., Floreani A., Rosina F., Ciaccio A., Cristoferi L., D'Amato D., Malinverno F., Mancuso C., Massironi S., Milani C., O'Donnell S. E., Ronca V., Barisani D., Lampertico P., Donato F., Fagiuoli S., Almasio P. L., Giannini E., Cursaro C., Colombo M., Valenti L., Miele L., Andriulli A., Niro G. A., Grattagliano I., Morini L., Casella G., Vinci M., Battezzati P. M., Crosignani A., Zuin M., Mattalia A., Calvaruso V., Colombo S., Benedetti A., Marzioni M., Galli A., Marra F., Tarocchi M., Picciotto A., Morisco F., Fabris L., Croce L. S., Tiribelli C., Toniutto P., Strazzabosco M., Ch'ng C. L., Rahman M., Yapp T., Sturgess R., Healey C., Czajkowski M., Gunasekera A., Gyawali P., Premchand P., Kapur K., Marley R., Foster G., Watson A., Dias A., Subhani J., Harvey R., McCorry R., Ramanaden D., Gasem J., Evans R., Mathialahan T., Shorrock C., Lipscomb G., Southern P., Tibble J., Gorard D., Palegwala A., Jones S., Dawwas M., Alexander G., Dolwani S., Prince M., Foxton M., Elphick D., Mitchison H., Gooding I., Karmo M., Saksena S., Mendall M., Patel M., Ede R., Austin A., Sayer J., Hankey L., Hovell C., Fisher N., Carter M., Koss K., Piotrowicz A., Grimley C., Neal D., Lim G., Levi S., Ala A., Broad A., Saeed A., Wood G., Brown J., Wilkinson M., Gordon H., Ramage J., Ridpath J., Ngatchu T., Grover B., Shaukat S., Shidrawi R., Abouda G., Ali F., Rees I., Salam I., Narain M., Brown A., Taylor-Robinson S., Williams S., Grellier L., Banim P., Das D., Chilton A., Heneghan M., Curtis H., Gess M., Drake I., Aldersley M., Davies M., Jones R., McNair A., Srirajaskanthan R., Pitcher M., Sen S., Bird G., Barnardo A., Kitchen P., Yoong K., Chirag O., Sivaramakrishnan N., MacFaul G., Jones D., Shah A., Evans C., Saha S., Pollock K., Bramley P., Mukhopadhya A., Fraser A., Mills P., Shallcross C., Campbell S., Bathgate A., Shepherd A., Dillon J., Rushbrook S., Przemioslo R., Macdonald C., Metcalf J., Shmueli U., Davis A., Naqvi A., Lee T., Ryder S. D., Collier J., Klass H., Ninkovic M., Cramp M., Sharer N., Aspinall R., Goggin P., Ghosh D., Douds A., Hoeroldt B., Booth J., Williams E., Hussaini H., Stableforth W., Ayres R., Thorburn D., Marshall E., Burroughs A., Mann S., Lombard M., Richardson P., Patanwala I., Maltby J., Brookes M., Mathew R., Vyas S., Singhal S., Gleeson D., Misra S., Butterworth J., George K., Harding T., Douglass A., Panter S., Shearman J., Bray G., Butcher G., Forton D., Mclindon J., Cowan M., Whatley G., Mandal A., Gupta H., Sanghi P., Jain S., Pereira S., Prasad G., Watts G., Wright M., Neuberger J., Gordon F., Unitt E., Grant A., Delahooke T., Higham A., Brind A., Cox M., Ramakrishnan S., King A., Collins C., Whalley S., Li A., Fraser J., Bell A., Wong V. S., Singhal A., Gee I., Ang Y., Ransford R., Gotto J., Millson C., Bowles J., Thomas C., Harrison M., Galaska R., Kendall J., Whiteman J., Lawlor C., Gray C., Elliott K., Mulvaney-Jones C., Hobson L., Van Duyvenvoorde G., Loftus A., Seward K., Penn R., Maiden J., Damant R., Hails J., Cloudsdale R., Silvestre V., Glenn S., Dungca E., Wheatley N., Doyle H., Kent M., Hamilton C., Braim D., Wooldridge H., Abrahams R., Paton A., Lancaster N., Gibbins A., Hogben K., Desousa P., Muscariu F., Musselwhite J., McKay A., Tan L., Foale C., Brighton J., Flahive K., Nambela E., Townshend P., Ford C., Holder S., Palmer C., Featherstone J., Nasseri M., Sadeghian J., Williams B., Rolls S. -A., Hynes A., Duggan C., Crossey M., Stansfield G., MacNicol C., Wilkins J., Wilhelmsen E., Raymode P., Lee H. -J., Durant E., Bishop R., Ncube N., Tripoli S., Casey R., Cowley C., Miller R., Houghton K., Ducker S., Wright F., Bird B., Baxter G., Keggans J., Hughes M., Grieve E., Young K., Williams D., Ocker K., Hines F., Martin K., Innes C., Valliani T., Fairlamb H., Thornthwaite S., Eastick A., Tanqueray E., Morrison J., Holbrook B., Browning J., Walker K., Congreave S., Verheyden J., Slininger S., Stafford L., O'Donnell D., Ainsworth M., Lord S., Kent L., March L., Dickson C., Simpson D., Longhurst B., Hayes M., Shpuza E., White N., Besley S., Pearson S., Wright A., Jones L., Gunter E., Dewhurst H., Fouracres A., Farrington L., Graves L., Marriott S., Leoni M., Tyrer D., Dali-kemmery L., Lambourne V., Green M., Sirdefield D., Amor K., Colley J., Shinder B., Jones J., Mills M., Carnahan M., Taylor N., Boulton K., Tregonning J., Brown C., Clifford G., Archer E., Hamilton M., Curtis J., Shewan T., Walsh S., Warner K., Netherton K., Mupudzi M., Gunson B., Gitahi J., Gocher D., Batham S., Pateman H., Desmennu S., Conder J., Clement D., Gallagher S., Orpe J., Chan P., Currie L., O'Donohoe L., Oblak M., Morgan L., Quinn M., Amey I., Baird Y., Cotterill D., Cumlat L., Winter L., Greer S., Spurdle K., Allison J., Dyer S., Sweeting H., Kordula J., Aiba Y., Nakamura H., Abiru S., Nagaoka S., Komori A., Yatsuhashi H., Ishibashi H., Ito M., Kawai Y., Kohn S. -S., Gervais O., Migita K., Katsushima S., Naganuma A., Sugi K., Komatsu T., Mannami T., Matsushita K., Yoshizawa K., Makita F., Nikami T., Nishimura H., Kouno H., Ota H., Komura T., Nakamura Y., Shimada M., Hirashima N., Komeda T., Ario K., Nakamuta M., Yamashita T., Furuta K., Kikuchi M., Naeshiro N., Takahashi H., Mano Y., Tsunematsu S., Yabuuchi I., Shimada Y., Yamauchi K., Sugimoto R., Sakai H., Mita E., Koda M., Tsuruta S., Kamitsukasa H., Sato T., Masaki N., Kobata T., Fukushima N., Higuchi N., Ohara Y., Muro T., Takesaki E., Takaki H., Yamamoto T., Kato M., Nagaoki Y., Hayashi S., Ishida J., Watanabe Y., Kobayashi M., Koga M., Saoshiro T., Yagura M., Hirata K., Takikawa H., Ohira H., Zeniya M., Abe M., Onji M., Kaneko S., Honda M., Arai K., Arinaga-Hino T., Hashimoto E., Taniai M., Umemura T., Joshita S., Nakao K., Ichikawa T., Shibata H., Yamagiwa S., Seike M., Honda K., Sakisaka S., Takeyama Y., Harada M., Senju M., Yokosuka O., Kanda T., Ueno Y., Kikuchi K., Ebinuma H., Himoto T., Yasunami M., Murata K., Mizokami M., Shimoda S., Miyake Y., Takaki A., Yamamoto K., Hirano K., Ichida T., Ido A., Tsubouchi H., Chayama K., Harada K., Nakanuma Y., Maehara Y., Taketomi A., Shirabe K., Soejima Y., Mori A., Yagi S., Uemoto S., Tanaka T., Yamashiki N., Tamura S., Sugawara Y., Kokudo N., Carbone M., Cardamone G., Duga S., Gershwin M. E., Seldin M. F., and Invernizzi P.
Abstract: Background & Aims: Genome-wide association studies in primary biliary cholangitis (PBC) have failed to find X chromosome (chrX) variants associated with the disease. Here, we specifically explore the chrX contribution to PBC, a sexually dimorphic complex autoimmune disease. Methods: We performed a chrX-wide association study, including genotype data from 5 genome-wide association studies (from Italy, United Kingdom, Canada, China, and Japan; 5244 case patients and 11,875 control individuals). Results: Single-marker association analyses found approximately 100 loci displaying P < 5 × 10–4, with the most significant being a signal within the OTUD5 gene (rs3027490; P = 4.80 × 10–6; odds ratio [OR], 1.39; 95% confidence interval [CI], 1.028–1.88; Japanese cohort). Although the transethnic meta-analysis evidenced only a suggestive signal (rs2239452, mapping within the PIM2 gene; OR, 1.17; 95% CI, 1.09–1.26; P = 9.93 × 10–8), the population-specific meta-analysis showed a genome-wide significant locus in East Asian individuals pointing to the same region (rs7059064, mapping within the GRIPAP1 gene; P = 6.2 × 10–9; OR, 1.33; 95% CI, 1.21–1.46). Indeed, rs7059064 tags a unique linkage disequilibrium block including 7 genes: TIMM17B, PQBP1, PIM2, SLC35A2, OTUD5, KCND1, and GRIPAP1, as well as a superenhancer (GH0XJ048933 within OTUD5) targeting all these genes. GH0XJ048933 is also predicted to target FOXP3, the main T-regulatory cell lineage specification factor. Consistently, OTUD5 and FOXP3 RNA levels were up-regulated in PBC case patients (1.75- and 1.64-fold, respectively). Conclusions: This work represents the first comprehensive study, to our knowledge, of the chrX contribution to the genetics of an autoimmune liver disease and shows a novel PBC-related genome-wide significant locus.
Published: 2021

19. An international genome-wide meta-analysis of primary biliary cholangitis: Novel risk loci and candidate drugs

Author: Cordell, H, Fryett, J, Ueno, K, Darlay, R, Aiba, Y, Hitomi, Y, Kawashima, M, Nishida, N, Khor, S, Gervais, O, Kawai, Y, Nagasaki, M, Tokunaga, K, Tang, R, Shi, Y, Li, Z, Juran, B, Atkinson, E, Gerussi, A, Carbone, M, Asselta, R, Cheung, A, de Andrade, M, Baras, A, Horowitz, J, Ferreira, M, Sun, D, Jones, D, Flack, S, Spicer, A, Mulcahy, V, Byan, J, Han, Y, Sandford, R, Lazaridis, K, Amos, C, Hirschfield, G, Seldin, M, Invernizzi, P, Siminovitch, K, Ma, X, Nakamura, M, Mells, G, Mason, A, Vincent, C, Xie, G, Zhang, J, Affronti, A, Almasio, P, Alvaro, D, Andreone, P, Andriulli, A, Azzaroli, F, Battezzati, P, Benedetti, A, Bragazzi, M, Brunetto, M, Bruno, S, Calvaruso, V, Cardinale, V, Casella, G, Cazzagon, N, Ciaccio, A, Coco, B, Colli, A, Colloredo, G, Colombo, M, Colombo, S, Cristoferi, L, Cursaro, C, Croce, L, Crosignani, A, D'Amato, D, Donato, F, Elia, G, Fabris, L, Fagiuoli, S, Ferrari, C, Floreani, A, Galli, A, Giannini, E, Grattagliano, I, Lampertico, P, Lleo, A, Malinverno, F, Mancuso, C, Marra, F, Marzioni, M, Massironi, S, Mattalia, A, Miele, L, Milani, C, Morini, L, Morisco, F, Muratori, L, Muratori, P, Niro, G, O'Donnell, S, Picciotto, A, Portincasa, P, Rigamonti, C, Ronca, V, Rosina, F, Spinzi, G, Strazzabosco, M, Tarocchi, M, Tiribelli, C, Toniutto, P, Valenti, L, Vinci, M, Zuin, M, Nakamura, H, Abiru, S, Nagaoka, S, Komori, A, Yatsuhashi, H, Ishibashi, H, Ito, M, Migita, K, Ohira, H, Katsushima, S, Naganuma, A, Sugi, K, Komatsu, T, Mannami, T, Matsushita, K, Yoshizawa, K, Makita, F, Nikami, T, Nishimura, H, Kouno, H, Ota, H, Komura, T, Nakamura, Y, Shimada, M, Hirashima, N, Komeda, T, Ario, K, Nakamuta, M, Yamashita, T, Furuta, K, Kikuchi, M, Naeshiro, N, Takahashi, H, Mano, Y, Tsunematsu, S, Yabuuchi, I, Shimada, Y, Yamauchi, K, Sugimoto, R, Sakai, H, Mita, E, Koda, M, Tsuruta, S, Kamitsukasa, H, Sato, T, Masaki, N, Kobata, T, Fukushima, N, Ohara, Y, Muro, T, Takesaki, E, Takaki, H, Yamamoto, T, Kato, M, Nagaoki, Y, Hayashi, S, Ishida, J, Watanabe, Y, Kobayashi, M, Koga, M, Saoshiro, T, Yagura, M, Hirata, K, Tanaka, A, Takikawa, H, Zeniya, M, Abe, M, Onji, M, Kaneko, S, Honda, M, Arai, K, Arinaga-Hino, T, Hashimoto, E, Taniai, M, Umemura, T, Joshita, S, Nakao, K, Ichikawa, T, Shibata, H, Yamagiwa, S, Seike, M, Honda, K, Sakisaka, S, Takeyama, Y, Harada, M, Senju, M, Yokosuka, O, Kanda, T, Ueno, Y, Kikuchi, K, Ebinuma, H, Himoto, T, Yasunami, M, Murata, K, Mizokami, M, Kawata, K, Shimoda, S, Miyake, Y, Takaki, A, Yamamoto, K, Hirano, K, Ichida, T, Ido, A, Tsubouchi, H, Chayama, K, Harada, K, Nakanuma, Y, Maehara, Y, Taketomi, A, Shirabe, K, Soejima, Y, Mori, A, Yagi, S, Uemoto, S, H, E, Tanaka, T, Yamashiki, N, Tamura, S, Sugawara, Y, Kokudo, N, Chalasani, N, Luketic, V, Odin, J, Chopra, K, Abecasis, G, Cantor, M, Coppola, G, Economides, A, Lotta, L, Overton, J, Reid, J, Shuldiner, A, Beechert, C, Forsythe, C, Fuller, E, Gu, Z, Lattari, M, Lopez, A, Schleicher, T, Padilla, M, Toledo, K, Widom, L, Wolf, S, Pradhan, M, Manoochehri, K, Ulloa, R, Bai, X, Balasubramanian, S, Barnard, L, Blumenfeld, A, Eom, G, Habegger, L, Hawes, A, Khalid, S, Maxwell, E, Salerno, W, Staples, J, Jones, M, Mitnaul, L, Sturgess, R, Healey, C, Yeoman, A, Gunasekera, A, Kooner, P, Kapur, K, Sathyanarayana, V, Kallis, Y, Subhani, J, Harvey, R, Mccorry, R, Rooney, P, Ramanaden, D, Evans, R, Mathialahan, T, Gasem, J, Shorrock, C, Bhalme, M, Southern, P, Tibble, J, Gorard, D, Jones, S, Srivastava, B, Foxton, M, Collins, C, Elphick, D, Karmo, M, Porras-Perez, F, Mendall, M, Yapp, T, Patel, M, Ede, R, Sayer, J, Jupp, J, Fisher, N, Carter, M, Koss, K, Shah, J, Piotrowicz, A, Scott, G, Grimley, C, Gooding, I, Williams, S, Tidbury, J, Lim, G, Cheent, K, Levi, S, Mansour, D, Beckley, M, Hollywood, C, Wong, T, Marley, R, Ramage, J, Gordon, H, Ridpath, J, Ngatchu, T, Bob Grover, V, Shidrawi, R, Abouda, G, Corless, L, Narain, M, Rees, I, Brown, A, Taylor-Robinson, S, Wilkins, J, Grellier, L, Banim, P, Das, D, Heneghan, M, Curtis, H, Matthews, H, Mohammed, F, Aldersley, M, Srirajaskanthan, R, Walker, G, Mcnair, A, Sharif, A, Sen, S, Bird, G, Prince, M, Prasad, G, Kitchen, P, Barnardo, A, Oza, C, Sivaramakrishnan, N, Gupta, P, Shah, A, Evans, C, Saha, S, Pollock, K, Bramley, P, Mukhopadhya, A, Barclay, S, Mcdonald, N, Bathgate, A, Palmer, K, Dillon, J, Rushbrook, S, Przemioslo, R, Mcdonald, C, Millar, A, Tai, C, Mitchell, S, Metcalf, J, Shaukat, S, Ninkovic, M, Shmueli, U, Davis, A, Naqvi, A, Lee, T, Ryder, S, Collier, J, Klass, H, Cramp, M, Sharer, N, Aspinall, R, Ghosh, D, Douds, A, Booth, J, Williams, E, Hussaini, H, Christie, J, Mann, S, Thorburn, D, Marshall, A, Patanwala, I, Ala, A, Maltby, J, Matthew, R, Corbett, C, Vyas, S, Singhal, S, Gleeson, D, Misra, S, Butterworth, J, George, K, Harding, T, Douglass, A, Mitchison, H, Panter, S, Shearman, J, Bray, G, Roberts, M, Butcher, G, Forton, D, Mahmood, Z, Cowan, M, Ch'Ng, C, Rahman, M, Whatley, G, Wesley, E, Mandal, A, Jain, S, Pereira, S, Wright, M, Trivedi, P, 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J., Fryett J. J., Ueno K., Darlay R., Aiba Y., Hitomi Y., Kawashima M., Nishida N., Khor S. -S., Gervais O., Kawai Y., Nagasaki M., Tokunaga K., Tang R., Shi Y., Li Z., Juran B. D., Atkinson E. J., Gerussi A., Carbone M., Asselta R., Cheung A., de Andrade M., Baras A., Horowitz J., Ferreira M. A. R., Sun D., Jones D. E., Flack S., Spicer A., Mulcahy V. L., Byan J., Han Y., Sandford R. N., Lazaridis K. N., Amos C. I., Hirschfield G. M., Seldin M. F., Invernizzi P., Siminovitch K. A., Ma X., Nakamura M., Mells G. F., Mason A., Vincent C., Xie G., Zhang J., Affronti A., Almasio P. L., Alvaro D., Andreone P., Andriulli A., Azzaroli F., Battezzati P. M., Benedetti A., Bragazzi M., Brunetto M., Bruno S., Calvaruso V., Cardinale V., Casella G., Cazzagon N., Ciaccio A., Coco B., Colli A., Colloredo G., Colombo M., Colombo S., Cristoferi L., Cursaro C., Croce L. S., Crosignani A., D'Amato D., Donato F., Elia G., Fabris L., Fagiuoli S., Ferrari C., Floreani A., Galli A., Giannini E., Grattagliano I., Lampertico P., Lleo A., Malinverno F., Mancuso C., Marra F., Marzioni M., Massironi S., Mattalia A., Miele L., Milani C., Morini L., Morisco F., Muratori L., Muratori P., Niro G. A., O'Donnell S., Picciotto A., Portincasa P., Rigamonti C., Ronca V., Rosina F., Spinzi G., Strazzabosco M., Tarocchi M., Tiribelli C., Toniutto P., Valenti L., Vinci M., Zuin M., Nakamura H., Abiru S., Nagaoka S., Komori A., Yatsuhashi H., Ishibashi H., Ito M., Migita K., Ohira H., Katsushima S., Naganuma A., Sugi K., Komatsu T., Mannami T., Matsushita K., Yoshizawa K., Makita F., Nikami T., Nishimura H., Kouno H., Ota H., Komura T., Nakamura Y., Shimada M., Hirashima N., Komeda T., Ario K., Nakamuta M., Yamashita T., Furuta K., Kikuchi M., Naeshiro N., Takahashi H., Mano Y., Tsunematsu S., Yabuuchi I., Shimada Y., Yamauchi K., Sugimoto R., Sakai H., Mita E., Koda M., Tsuruta S., Kamitsukasa H., Sato T., Masaki N., Kobata T., Fukushima N., Ohara Y., Muro T., Takesaki E., Takaki H., Yamamoto T., Kato M., Nagaoki Y., Hayashi S., Ishida J., Watanabe Y., Kobayashi M., Koga M., Saoshiro T., Yagura M., Hirata K., Tanaka A., Takikawa H., Zeniya M., Abe M., Onji M., Kaneko S., Honda M., Arai K., Arinaga-Hino T., Hashimoto E., Taniai M., Umemura T., Joshita S., Nakao K., Ichikawa T., Shibata H., Yamagiwa S., Seike M., Honda K., Sakisaka S., Takeyama Y., Harada M., Senju M., Yokosuka O., Kanda T., Ueno Y., Kikuchi K., Ebinuma H., Himoto T., Yasunami M., Murata K., Mizokami M., Kawata K., Shimoda S., Miyake Y., Takaki A., Yamamoto K., Hirano K., Ichida T., Ido A., Tsubouchi H., Chayama K., Harada K., Nakanuma Y., Maehara Y., Taketomi A., Shirabe K., Soejima Y., Mori A., Yagi S., Uemoto S., H E., Tanaka T., Yamashiki N., Tamura S., Sugawara Y., Kokudo N., Chalasani N., Luketic V., Odin J., Chopra K., Abecasis G., Cantor M., Coppola G., Economides A., Lotta L. A., Overton J. D., Reid J. G., Shuldiner A., Beechert C., Forsythe C., Fuller E. D., Gu Z., Lattari M., Lopez A., Schleicher T. D., Padilla M. S., Toledo K., Widom L., Wolf S. E., Pradhan M., Manoochehri K., Ulloa R. H., Bai X., Balasubramanian S., Barnard L., Blumenfeld A., Eom G., Habegger L., Hawes A., Khalid S., Maxwell E. K., Salerno W., Staples J. C., Jones M. B., Mitnaul L. J., Sturgess R., Healey C., Yeoman A., Gunasekera A. V., Kooner P., Kapur K., Sathyanarayana V., Kallis Y., Subhani J., Harvey R., McCorry R., Rooney P., Ramanaden D., Evans R., Mathialahan T., Gasem J., Shorrock C., Bhalme M., Southern P., Tibble J. A., Gorard D. A., Jones S., Mells G., Mulcahy V., Srivastava B., Foxton M. R., Collins C. E., Elphick D., Karmo M., Porras-Perez F., Mendall M., Yapp T., Patel M., Ede R., Sayer J., Jupp J., Fisher N., Carter M. J., Koss K., Shah J., Piotrowicz A., Scott G., Grimley C., Gooding I. R., Williams S., Tidbury J., Lim G., Cheent K., Levi S., Mansour D., Beckley M., Hollywood C., Wong T., Marley R., Ramage J., Gordon H. M., Ridpath J., Ngatchu T., Bob Grover V. P., Shidrawi R. G., Abouda G., Corless L., Narain M., Rees I., Brown A., Taylor-Robinson S., Wilkins J., Grellier L., Banim P., Das D., Heneghan M. A., Curtis H., Matthews H. C., Mohammed F., Aldersley M., Srirajaskanthan R., Walker G., McNair A., Sharif A., Sen S., Bird G., Prince M. I., Prasad G., Kitchen P., Barnardo A., Oza C., Sivaramakrishnan N. N., Gupta P., Shah A., Evans C. D., Saha S., Pollock K., Bramley P., Mukhopadhya A., Barclay S. T., McDonald N., Bathgate A. J., Palmer K., Dillon J. F., Rushbrook S. M., Przemioslo R., McDonald C., Millar A., Tai C., Mitchell S., Metcalf J., Shaukat S., Ninkovic M., Shmueli U., Davis A., Naqvi A., Lee T. J., Ryder S., Collier J., Klass H., Cramp M. E., Sharer N., Aspinall R., Ghosh D., Douds A. C., Booth J., Williams E., Hussaini H., Christie J., Mann S., Thorburn D., Marshall A., Patanwala I., Ala A., Maltby J., Matthew R., Corbett C., Vyas S., Singhal S., Gleeson D., Misra S., Butterworth J., George K., Harding T., Douglass A., Mitchison H., Panter S., Shearman J., Bray G., Roberts M., Butcher G., Forton D., Mahmood Z., Cowan M., Ch'ng C. L., Rahman M., Whatley G. C. A., Wesley E., Mandal A., Jain S., Pereira S. P., Wright M., Trivedi P., Gordon F. H., Unitt E., Palejwala A., Austin A., Vemala V., Grant A., Higham A. D., Brind A., Mathew R., Cox M., Ramakrishnan S., King A., Whalley S., Fraser J., Thomson S. J., Bell A., Wong V. S., Kia R., Gee I., Keld R., Ransford R., Gotto J., Millson C., Cordell, H, Fryett, J, Ueno, K, Darlay, R, Aiba, Y, Hitomi, Y, Kawashima, M, Nishida, N, Khor, S, Gervais, O, Kawai, Y, Nagasaki, M, Tokunaga, K, Tang, R, Shi, Y, Li, Z, Juran, B, Atkinson, E, Gerussi, A, Carbone, M, Asselta, R, Cheung, A, de Andrade, M, Baras, A, Horowitz, J, Ferreira, M, Sun, D, Jones, D, Flack, S, Spicer, A, Mulcahy, V, Byan, J, Han, Y, Sandford, R, Lazaridis, K, Amos, C, Hirschfield, G, Seldin, M, Invernizzi, P, Siminovitch, K, Ma, X, Nakamura, M, Mells, G, Mason, A, Vincent, C, Xie, G, Zhang, J, Affronti, A, Almasio, P, Alvaro, D, Andreone, P, Andriulli, A, Azzaroli, F, Battezzati, P, Benedetti, A, Bragazzi, M, Brunetto, M, Bruno, S, Calvaruso, V, Cardinale, V, Casella, G, Cazzagon, N, Ciaccio, A, Coco, B, Colli, A, Colloredo, G, Colombo, M, Colombo, S, Cristoferi, L, Cursaro, C, Croce, L, Crosignani, A, D'Amato, D, Donato, F, Elia, G, Fabris, L, Fagiuoli, S, Ferrari, C, Floreani, A, Galli, A, Giannini, E, Grattagliano, I, Lampertico, P, Lleo, A, Malinverno, F, Mancuso, C, Marra, F, Marzioni, M, Massironi, S, Mattalia, A, Miele, L, Milani, C, Morini, L, Morisco, F, Muratori, L, Muratori, P, Niro, G, O'Donnell, S, Picciotto, A, Portincasa, P, Rigamonti, C, Ronca, V, Rosina, F, Spinzi, G, Strazzabosco, M, Tarocchi, M, Tiribelli, C, Toniutto, P, Valenti, L, Vinci, M, Zuin, M, Nakamura, H, Abiru, S, Nagaoka, S, Komori, A, Yatsuhashi, H, Ishibashi, H, Ito, M, Migita, K, Ohira, H, Katsushima, S, Naganuma, A, Sugi, K, Komatsu, T, Mannami, T, Matsushita, K, Yoshizawa, K, Makita, F, Nikami, T, Nishimura, H, Kouno, H, Ota, H, Komura, T, Nakamura, Y, Shimada, M, Hirashima, N, Komeda, T, Ario, K, Nakamuta, M, Yamashita, T, Furuta, K, Kikuchi, M, Naeshiro, N, Takahashi, H, Mano, Y, Tsunematsu, S, Yabuuchi, I, Shimada, Y, Yamauchi, K, Sugimoto, R, Sakai, H, Mita, E, Koda, M, Tsuruta, S, Kamitsukasa, H, Sato, T, Masaki, N, Kobata, T, Fukushima, N, Ohara, Y, Muro, T, Takesaki, E, Takaki, H, Yamamoto, T, Kato, M, Nagaoki, Y, Hayashi, S, Ishida, J, Watanabe, Y, Kobayashi, M, Koga, M, Saoshiro, T, Yagura, M, Hirata, K, Tanaka, A, Takikawa, H, Zeniya, M, Abe, M, Onji, M, Kaneko, S, Honda, M, Arai, K, Arinaga-Hino, T, Hashimoto, E, Taniai, M, Umemura, T, Joshita, S, Nakao, K, Ichikawa, T, Shibata, H, Yamagiwa, S, Seike, M, Honda, K, Sakisaka, S, Takeyama, Y, Harada, M, Senju, M, Yokosuka, O, Kanda, T, Ueno, Y, Kikuchi, K, Ebinuma, H, Himoto, T, Yasunami, M, Murata, K, Mizokami, M, Kawata, K, Shimoda, S, Miyake, Y, Takaki, A, Yamamoto, K, Hirano, K, Ichida, T, Ido, A, Tsubouchi, H, Chayama, K, Harada, K, Nakanuma, Y, Maehara, Y, Taketomi, A, Shirabe, K, Soejima, Y, Mori, A, Yagi, S, Uemoto, S, H, E, Tanaka, T, Yamashiki, N, Tamura, S, Sugawara, Y, Kokudo, N, Chalasani, N, Luketic, V, Odin, J, Chopra, K, Abecasis, G, Cantor, M, Coppola, G, Economides, A, Lotta, L, Overton, J, Reid, J, Shuldiner, A, Beechert, C, Forsythe, C, Fuller, E, Gu, Z, Lattari, M, Lopez, A, Schleicher, T, Padilla, M, Toledo, K, Widom, L, Wolf, S, Pradhan, M, Manoochehri, K, Ulloa, R, Bai, X, Balasubramanian, S, Barnard, L, Blumenfeld, A, Eom, G, Habegger, L, Hawes, A, Khalid, S, Maxwell, E, Salerno, W, Staples, J, Jones, M, Mitnaul, L, Sturgess, R, Healey, C, Yeoman, A, Gunasekera, A, Kooner, P, Kapur, K, Sathyanarayana, V, Kallis, Y, Subhani, J, Harvey, R, Mccorry, R, Rooney, P, Ramanaden, D, Evans, R, Mathialahan, T, Gasem, J, Shorrock, C, Bhalme, M, Southern, P, Tibble, J, Gorard, D, Jones, S, Srivastava, B, Foxton, M, Collins, C, Elphick, D, Karmo, M, Porras-Perez, F, Mendall, M, Yapp, T, Patel, M, Ede, R, Sayer, J, Jupp, J, Fisher, N, Carter, M, Koss, K, Shah, J, Piotrowicz, A, Scott, G, Grimley, C, Gooding, I, Williams, S, Tidbury, J, Lim, G, Cheent, K, Levi, S, Mansour, D, Beckley, M, Hollywood, C, Wong, T, Marley, R, Ramage, J, Gordon, H, Ridpath, J, Ngatchu, T, Bob Grover, V, Shidrawi, R, Abouda, G, Corless, L, Narain, M, Rees, I, Brown, A, Taylor-Robinson, S, Wilkins, J, Grellier, L, Banim, P, Das, D, Heneghan, M, Curtis, H, Matthews, H, Mohammed, F, Aldersley, M, Srirajaskanthan, R, Walker, G, Mcnair, A, Sharif, A, Sen, S, Bird, G, Prince, M, Prasad, G, Kitchen, P, Barnardo, A, Oza, C, Sivaramakrishnan, N, Gupta, P, Shah, A, Evans, C, Saha, S, Pollock, K, Bramley, P, Mukhopadhya, A, Barclay, S, Mcdonald, N, Bathgate, A, Palmer, K, Dillon, J, Rushbrook, S, Przemioslo, R, Mcdonald, C, Millar, A, Tai, C, Mitchell, S, Metcalf, J, Shaukat, S, Ninkovic, M, Shmueli, U, Davis, A, Naqvi, A, Lee, T, Ryder, S, Collier, J, Klass, H, Cramp, M, Sharer, N, Aspinall, R, Ghosh, D, Douds, A, Booth, J, Williams, E, Hussaini, H, Christie, J, Mann, S, Thorburn, D, Marshall, A, Patanwala, I, Ala, A, Maltby, J, Matthew, R, Corbett, C, Vyas, S, Singhal, S, Gleeson, D, Misra, S, Butterworth, J, George, K, Harding, T, Douglass, A, Mitchison, H, Panter, S, Shearman, J, Bray, G, Roberts, M, Butcher, G, Forton, D, Mahmood, Z, Cowan, M, Ch'Ng, C, Rahman, M, Whatley, G, Wesley, E, Mandal, A, Jain, S, Pereira, S, Wright, M, Trivedi, P, Gordon, F, Unitt, E, Palejwala, A, Austin, A, Vemala, V, Grant, A, Higham, A, Brind, A, Mathew, R, Cox, M, Ramakrishnan, S, King, A, Whalley, S, Fraser, J, Thomson, S, Bell, A, Wong, V, Kia, R, Gee, I, Keld, R, Ransford, R, Gotto, J, Millson, C, Cordell H. J., Fryett J. J., Ueno K., Darlay R., Aiba Y., Hitomi Y., Kawashima M., Nishida N., Khor S. -S., Gervais O., Kawai Y., Nagasaki M., Tokunaga K., Tang R., Shi Y., Li Z., Juran B. D., Atkinson E. J., Gerussi A., Carbone M., Asselta R., Cheung A., de Andrade M., Baras A., Horowitz J., Ferreira M. A. R., Sun D., Jones D. E., Flack S., Spicer A., Mulcahy V. L., Byan J., Han Y., Sandford R. N., Lazaridis K. N., Amos C. I., Hirschfield G. M., Seldin M. F., Invernizzi P., Siminovitch K. A., Ma X., Nakamura M., Mells G. F., Mason A., Vincent C., Xie G., Zhang J., Affronti A., Almasio P. L., Alvaro D., Andreone P., Andriulli A., Azzaroli F., Battezzati P. M., Benedetti A., Bragazzi M., Brunetto M., Bruno S., Calvaruso V., Cardinale V., Casella G., Cazzagon N., Ciaccio A., Coco B., Colli A., Colloredo G., Colombo M., Colombo S., Cristoferi L., Cursaro C., Croce L. S., Crosignani A., D'Amato D., Donato F., Elia G., Fabris L., Fagiuoli S., Ferrari C., Floreani A., Galli A., Giannini E., Grattagliano I., Lampertico P., Lleo A., Malinverno F., Mancuso C., Marra F., Marzioni M., Massironi S., Mattalia A., Miele L., Milani C., Morini L., Morisco F., Muratori L., Muratori P., Niro G. A., O'Donnell S., Picciotto A., Portincasa P., Rigamonti C., Ronca V., Rosina F., Spinzi G., Strazzabosco M., Tarocchi M., Tiribelli C., Toniutto P., Valenti L., Vinci M., Zuin M., Nakamura H., Abiru S., Nagaoka S., Komori A., Yatsuhashi H., Ishibashi H., Ito M., Migita K., Ohira H., Katsushima S., Naganuma A., Sugi K., Komatsu T., Mannami T., Matsushita K., Yoshizawa K., Makita F., Nikami T., Nishimura H., Kouno H., Ota H., Komura T., Nakamura Y., Shimada M., Hirashima N., Komeda T., Ario K., Nakamuta M., Yamashita T., Furuta K., Kikuchi M., Naeshiro N., Takahashi H., Mano Y., Tsunematsu S., Yabuuchi I., Shimada Y., Yamauchi K., Sugimoto R., Sakai H., Mita E., Koda M., Tsuruta S., Kamitsukasa H., Sato T., Masaki N., Kobata T., Fukushima N., Ohara Y., Muro T., Takesaki E., Takaki H., Yamamoto T., Kato M., Nagaoki Y., Hayashi S., Ishida J., Watanabe Y., Kobayashi M., Koga M., Saoshiro T., Yagura M., Hirata K., Tanaka A., Takikawa H., Zeniya M., Abe M., Onji M., Kaneko S., Honda M., Arai K., Arinaga-Hino T., Hashimoto E., Taniai M., Umemura T., Joshita S., Nakao K., Ichikawa T., Shibata H., Yamagiwa S., Seike M., Honda K., Sakisaka S., Takeyama Y., Harada M., Senju M., Yokosuka O., Kanda T., Ueno Y., Kikuchi K., Ebinuma H., Himoto T., Yasunami M., Murata K., Mizokami M., Kawata K., Shimoda S., Miyake Y., Takaki A., Yamamoto K., Hirano K., Ichida T., Ido A., Tsubouchi H., Chayama K., Harada K., Nakanuma Y., Maehara Y., Taketomi A., Shirabe K., Soejima Y., Mori A., Yagi S., Uemoto S., H E., Tanaka T., Yamashiki N., Tamura S., Sugawara Y., Kokudo N., Chalasani N., Luketic V., Odin J., Chopra K., Abecasis G., Cantor M., Coppola G., Economides A., Lotta L. A., Overton J. D., Reid J. G., Shuldiner A., Beechert C., Forsythe C., Fuller E. D., Gu Z., Lattari M., Lopez A., Schleicher T. D., Padilla M. S., Toledo K., Widom L., Wolf S. E., Pradhan M., Manoochehri K., Ulloa R. H., Bai X., Balasubramanian S., Barnard L., Blumenfeld A., Eom G., Habegger L., Hawes A., Khalid S., Maxwell E. K., Salerno W., Staples J. C., Jones M. B., Mitnaul L. J., Sturgess R., Healey C., Yeoman A., Gunasekera A. V., Kooner P., Kapur K., Sathyanarayana V., Kallis Y., Subhani J., Harvey R., McCorry R., Rooney P., Ramanaden D., Evans R., Mathialahan T., Gasem J., Shorrock C., Bhalme M., Southern P., Tibble J. A., Gorard D. A., Jones S., Mells G., Mulcahy V., Srivastava B., Foxton M. R., Collins C. E., Elphick D., Karmo M., Porras-Perez F., Mendall M., Yapp T., Patel M., Ede R., Sayer J., Jupp J., Fisher N., Carter M. J., Koss K., Shah J., Piotrowicz A., Scott G., Grimley C., Gooding I. R., Williams S., Tidbury J., Lim G., Cheent K., Levi S., Mansour D., Beckley M., Hollywood C., Wong T., Marley R., Ramage J., Gordon H. M., Ridpath J., Ngatchu T., Bob Grover V. P., Shidrawi R. G., Abouda G., Corless L., Narain M., Rees I., Brown A., Taylor-Robinson S., Wilkins J., Grellier L., Banim P., Das D., Heneghan M. A., Curtis H., Matthews H. C., Mohammed F., Aldersley M., Srirajaskanthan R., Walker G., McNair A., Sharif A., Sen S., Bird G., Prince M. I., Prasad G., Kitchen P., Barnardo A., Oza C., Sivaramakrishnan N. N., Gupta P., Shah A., Evans C. D., Saha S., Pollock K., Bramley P., Mukhopadhya A., Barclay S. T., McDonald N., Bathgate A. J., Palmer K., Dillon J. F., Rushbrook S. M., Przemioslo R., McDonald C., Millar A., Tai C., Mitchell S., Metcalf J., Shaukat S., Ninkovic M., Shmueli U., Davis A., Naqvi A., Lee T. J., Ryder S., Collier J., Klass H., Cramp M. E., Sharer N., Aspinall R., Ghosh D., Douds A. C., Booth J., Williams E., Hussaini H., Christie J., Mann S., Thorburn D., Marshall A., Patanwala I., Ala A., Maltby J., Matthew R., Corbett C., Vyas S., Singhal S., Gleeson D., Misra S., Butterworth J., George K., Harding T., Douglass A., Mitchison H., Panter S., Shearman J., Bray G., Roberts M., Butcher G., Forton D., Mahmood Z., Cowan M., Ch'ng C. L., Rahman M., Whatley G. C. A., Wesley E., Mandal A., Jain S., Pereira S. P., Wright M., Trivedi P., Gordon F. H., Unitt E., Palejwala A., Austin A., Vemala V., Grant A., Higham A. D., Brind A., Mathew R., Cox M., Ramakrishnan S., King A., Whalley S., Fraser J., Thomson S. J., Bell A., Wong V. S., Kia R., Gee I., Keld R., Ransford R., Gotto J., and Millson C.
Abstract: Backgrounds & Aims: Primary biliary cholangitis (PBC) is a chronic liver disease in which autoimmune destruction of the small intrahepatic bile ducts eventually leads to cirrhosis. Many patients have inadequate response to licensed medications, motivating the search for novel therapies. Previous genome-wide association studies (GWAS) and meta-analyses (GWMA) of PBC have identified numerous risk loci for this condition, providing insight into its aetiology. We undertook the largest GWMA of PBC to date, aiming to identify additional risk loci and prioritise candidate genes for in silico drug efficacy screening. Methods: We combined new and existing genotype data for 10,516 cases and 20,772 controls from 5 European and 2 East Asian cohorts. Results: We identified 56 genome-wide significant loci (20 novel) including 46 in European, 13 in Asian, and 41 in combined cohorts; and a 57th genome-wide significant locus (also novel) in conditional analysis of the European cohorts. Candidate genes at newly identified loci include FCRL3, INAVA, PRDM1, IRF7, CCR6, CD226, and IL12RB1, which each play key roles in immunity. Pathway analysis reiterated the likely importance of pattern recognition receptor and TNF signalling, JAK-STAT signalling, and differentiation of T helper (TH)1 and TH17 cells in the pathogenesis of this disease. Drug efficacy screening identified several medications predicted to be therapeutic in PBC, some of which are well-established in the treatment of other autoimmune disorders. Conclusions: This study has identified additional risk loci for PBC, provided a hierarchy of agents that could be trialled in this condition, and emphasised the value of genetic and genomic approaches to drug discovery in complex disorders. Lay summary: Primary biliary cholangitis (PBC) is a chronic liver disease that eventually leads to cirrhosis. In this study, we analysed genetic information from 10,516 people with PBC and 20,772 healthy individuals recruited in Canada, China
Published: 2021

20. Large-scale migration into Britain during the Middle to Late Bronze Age

Author: Patterson, Nick, Isakov, Michael, Booth, Thomas, Büster, Lindsey, Fischer, Claire-Elise, Olalde, Iñigo, Ringbauer, Harald, Akbari, Ali, Cheronet, Olivia, Bleasdale, Madeleine, Adamski, Nicole, Altena, Eveline, Bernardos, Rebecca, Brace, Selina, Broomandkhoshbacht, Nasreen, Callan, Kimberly, Candilio, Francesca, Culleton, Brendan, Curtis, Elizabeth, Demetz, Lea, Carlson, Kellie Sara Duffett, Fernandes, Daniel M., Foody, M. George B., Freilich, Suzanne, Goodchild, Helen, Kearns, Aisling, Lawson, Ann Marie, Lazaridis, Iosif, Mah, Matthew, Mallick, Swapan, Mandl, Kirsten, Micco, Adam, Michel, Megan, Morante, Guillermo Bravo, Oppenheimer, Jonas, Özdoğan, Kadir Toykan, Qiu, Lijun, Schattke, Constanze, Stewardson, Kristin, Workman, J. Noah, Zalzala, Fatma, Zhang, Zhao, Agustí, Bibiana, Allen, Tim, Almássy, Katalin, Amkreutz, Luc, Ash, Abigail, Baillif-Ducros, Christèle, Barclay, Alistair, Bartosiewicz, László, Baxter, Katherine, Bernert, Zsolt, Blažek, Jan, Bodružić, Mario, Boissinot, Philippe, Bonsall, Clive, Bradley, Pippa, Brittain, Marcus, Brookes, Alison, Brown, Fraser, Brown, Lisa, Brunning, Richard, Budd, Chelsea, Burmaz, Josip, Canet, Sylvain, Carnicero-Cáceres, Silvia, Čaušević-Bully, Morana, Chamberlain, Andrew, Chauvin, Sébastien, Clough, Sharon, Čondić, Natalija, Coppa, Alfredo, Craig, Oliver, Črešnar, Matija, Cummings, Vicki, Czifra, Szabolcs, Danielisová, Alžběta, Daniels, Robin, Davies, Alex, de Jersey, Philip, Deacon, Jody, Deminger, Csilla, Ditchfield, Peter W., Dizdar, Marko, Dobeš, Miroslav, Dobisíková, Miluše, Domboróczki, László, Drinkall, Gail, Đukić, Ana, Edwards, Ceiridwen J., Ernée, Michal, Evans, Christopher, Evans, Jane, Fernández-Götz, Manuel, Filipović, Slavica, Fitzpatrick, Andrew, Fokkens, Harry, Fowler, Chris, Fox, Allison, Gallina, Zsolt, Gamble, Michelle, González Morales, Manuel R., González-Rabanal, Borja, Green, Adrian, Gyenesei, Katalin, Habermehl, Diederick, Hajdu, Tamás, Hamilton, Derek, Harris, James, Hayden, Chris, Hendriks, Joep, Hernu, Bénédicte, Hey, Gill, Horňák, Milan, Ilon, Gábor, Istvánovits, Eszter, Jones, Andy M., Kavur, Martina Blečić, Kazek, Kevin, Kenyon, Robert A., Khreisheh, Amal, Kiss, Viktória, Kleijne, Jos, Knight, Mark, Kootker, Lisette M., Kovács, Péter F., Kozubová, Anita, Kulcsár, Gabriella, Kulcsár, Valéria, Le Pennec, Christophe, Legge, Michael, Leivers, Matt, Loe, Louise, López-Costas, Olalla, Lord, Tom, Los, Dženi, Lyall, James, Marín-Arroyo, Ana B., Mason, Philip, Matošević, Damir, Maxted, Andy, McIntyre, Lauren, McKinley, Jacqueline, McSweeney, Kathleen, Meijlink, Bernard, Mende, Balázs G., Menđušić, Marko, Metlička, Milan, Meyer, Sophie, Mihovilić, Kristina, Milasinovic, Lidija, Minnitt, Steve, Moore, Joanna, Morley, Geoff, Mullan, Graham, Musilová, Margaréta, Neil, Benjamin, Nicholls, Rebecca, Novak, Mario, Pala, Maria, Papworth, Martin, Paresys, Cécile, Patten, Ricky, Perkić, Domagoj, Pesti, Krisztina, Petit, Alba, Petriščáková, Katarína, Pichon, Coline, Pickard, Catriona, Pilling, Zoltán, Price, T. Douglas, Radović, Siniša, Redfern, Rebecca, Resutík, Branislav, Rhodes, Daniel T., Richards, Martin B., Roberts, Amy, Roefstra, Jean, Sankot, Pavel, Šefčáková, Alena, Sheridan, Alison, Skae, Sabine, Šmolíková, Miroslava, Somogyi, Krisztina, Somogyvári, Ágnes, Stephens, Mark, Szabó, Géza, Szécsényi-Nagy, Anna, Szeniczey, Tamás, Tabor, Jonathan, Tankó, Károly, Maria, Clenis Tavarez, Terry, Rachel, Teržan, Biba, Teschler-Nicola, Maria, Torres-Martínez, Jesús F., Trapp, Julien, Turle, Ross, Ujvári, Ferenc, van der Heiden, Menno, Veleminsky, Petr, Veselka, Barbara, Vytlačil, Zdeněk, Waddington, Clive, Ware, Paula, Wilkinson, Paul, Wilson, Linda, Wiseman, Rob, Young, Eilidh, Zaninović, Joško, Žitňan, Andrej, Lalueza-Fox, Carles, de Knijff, Peter, Barnes, Ian, Halkon, Peter, Thomas, Mark G., Kennett, Douglas J., Cunliffe, Barry, Lillie, Malcolm, Rohland, Nadin, Pinhasi, Ron, Armit, Ian, Reich, David, Patterson, Nick, Isakov, Michael, Booth, Thomas, Büster, Lindsey, Fischer, Claire-Elise, Olalde, Iñigo, Ringbauer, Harald, Akbari, Ali, Cheronet, Olivia, Bleasdale, Madeleine, Adamski, Nicole, Altena, Eveline, Bernardos, Rebecca, Brace, Selina, Broomandkhoshbacht, Nasreen, Callan, Kimberly, Candilio, Francesca, Culleton, Brendan, Curtis, Elizabeth, Demetz, Lea, Carlson, Kellie Sara Duffett, Fernandes, Daniel M., Foody, M. George B., Freilich, Suzanne, Goodchild, Helen, Kearns, Aisling, Lawson, Ann Marie, Lazaridis, Iosif, Mah, Matthew, Mallick, Swapan, Mandl, Kirsten, Micco, Adam, Michel, Megan, Morante, Guillermo Bravo, Oppenheimer, Jonas, Özdoğan, Kadir Toykan, Qiu, Lijun, Schattke, Constanze, Stewardson, Kristin, Workman, J. Noah, Zalzala, Fatma, Zhang, Zhao, Agustí, Bibiana, Allen, Tim, Almássy, Katalin, Amkreutz, Luc, Ash, Abigail, Baillif-Ducros, Christèle, Barclay, Alistair, Bartosiewicz, László, Baxter, Katherine, Bernert, Zsolt, Blažek, Jan, Bodružić, Mario, Boissinot, Philippe, Bonsall, Clive, Bradley, Pippa, Brittain, Marcus, Brookes, Alison, Brown, Fraser, Brown, Lisa, Brunning, Richard, Budd, Chelsea, Burmaz, Josip, Canet, Sylvain, Carnicero-Cáceres, Silvia, Čaušević-Bully, Morana, Chamberlain, Andrew, Chauvin, Sébastien, Clough, Sharon, Čondić, Natalija, Coppa, Alfredo, Craig, Oliver, Črešnar, Matija, Cummings, Vicki, Czifra, Szabolcs, Danielisová, Alžběta, Daniels, Robin, Davies, Alex, de Jersey, Philip, Deacon, Jody, Deminger, Csilla, Ditchfield, Peter W., Dizdar, Marko, Dobeš, Miroslav, Dobisíková, Miluše, Domboróczki, László, Drinkall, Gail, Đukić, Ana, Edwards, Ceiridwen J., Ernée, Michal, Evans, Christopher, Evans, Jane, Fernández-Götz, Manuel, Filipović, Slavica, Fitzpatrick, Andrew, Fokkens, Harry, Fowler, Chris, Fox, Allison, Gallina, Zsolt, Gamble, Michelle, González Morales, Manuel R., González-Rabanal, Borja, Green, Adrian, Gyenesei, Katalin, Habermehl, Diederick, Hajdu, Tamás, Hamilton, Derek, Harris, James, Hayden, Chris, Hendriks, Joep, Hernu, Bénédicte, Hey, Gill, Horňák, Milan, Ilon, Gábor, Istvánovits, Eszter, Jones, Andy M., Kavur, Martina Blečić, Kazek, Kevin, Kenyon, Robert A., Khreisheh, Amal, Kiss, Viktória, Kleijne, Jos, Knight, Mark, Kootker, Lisette M., Kovács, Péter F., Kozubová, Anita, Kulcsár, Gabriella, Kulcsár, Valéria, Le Pennec, Christophe, Legge, Michael, Leivers, Matt, Loe, Louise, López-Costas, Olalla, Lord, Tom, Los, Dženi, Lyall, James, Marín-Arroyo, Ana B., Mason, Philip, Matošević, Damir, Maxted, Andy, McIntyre, Lauren, McKinley, Jacqueline, McSweeney, Kathleen, Meijlink, Bernard, Mende, Balázs G., Menđušić, Marko, Metlička, Milan, Meyer, Sophie, Mihovilić, Kristina, Milasinovic, Lidija, Minnitt, Steve, Moore, Joanna, Morley, Geoff, Mullan, Graham, Musilová, Margaréta, Neil, Benjamin, Nicholls, Rebecca, Novak, Mario, Pala, Maria, Papworth, Martin, Paresys, Cécile, Patten, Ricky, Perkić, Domagoj, Pesti, Krisztina, Petit, Alba, Petriščáková, Katarína, Pichon, Coline, Pickard, Catriona, Pilling, Zoltán, Price, T. Douglas, Radović, Siniša, Redfern, Rebecca, Resutík, Branislav, Rhodes, Daniel T., Richards, Martin B., Roberts, Amy, Roefstra, Jean, Sankot, Pavel, Šefčáková, Alena, Sheridan, Alison, Skae, Sabine, Šmolíková, Miroslava, Somogyi, Krisztina, Somogyvári, Ágnes, Stephens, Mark, Szabó, Géza, Szécsényi-Nagy, Anna, Szeniczey, Tamás, Tabor, Jonathan, Tankó, Károly, Maria, Clenis Tavarez, Terry, Rachel, Teržan, Biba, Teschler-Nicola, Maria, Torres-Martínez, Jesús F., Trapp, Julien, Turle, Ross, Ujvári, Ferenc, van der Heiden, Menno, Veleminsky, Petr, Veselka, Barbara, Vytlačil, Zdeněk, Waddington, Clive, Ware, Paula, Wilkinson, Paul, Wilson, Linda, Wiseman, Rob, Young, Eilidh, Zaninović, Joško, Žitňan, Andrej, Lalueza-Fox, Carles, de Knijff, Peter, Barnes, Ian, Halkon, Peter, Thomas, Mark G., Kennett, Douglas J., Cunliffe, Barry, Lillie, Malcolm, Rohland, Nadin, Pinhasi, Ron, Armit, Ian, and Reich, David
Abstract: Present-day people from England and Wales harbour more ancestry derived from Early European Farmers (EEF) than people of the Early Bronze Age1. To understand this, we generated genome-wide data from 793 individuals, increasing data from the Middle to Late Bronze and Iron Age in Britain by 12-fold, and Western and Central Europe by 3.5-fold. Between 1000 and 875 BC, EEF ancestry increased in southern Britain (England and Wales) but not northern Britain (Scotland) due to incorporation of migrants who arrived at this time and over previous centuries, and who were genetically most similar to ancient individuals from France. These migrants contributed about half the ancestry of Iron Age people of England and Wales, thereby creating a plausible vector for the spread of early Celtic languages into Britain. These patterns are part of a broader trend of EEF ancestry becoming more similar across central and western Europe in the Middle to Late Bronze Age, coincident with archaeological evidence of intensified cultural exchange2-6. There was comparatively less gene flow from continental Europe during the Iron Age, and Britain's independent genetic trajectory is also reflected in the rise of the allele conferring lactase persistence to ~50% by this time compared to ~7% in central Europe where it rose rapidly in frequency only a millennium later. This suggests that dairy products were used in qualitatively different ways in Britain and in central Europe over this period.
Published: 2022
Full Text: View/download PDF

21. Large-scale migration into Britain during the Middle to Late Bronze Age

Author: Patterson, Nick, Isakov, Michael, Booth, Thomas, Buster, Lindsey, Fischer, Claire-Elise, Olalde, Inigo, Ringbauer, Harald, Akbari, Ali, Cheronet, Olivia, Bleasdale, Madeleine, Adamski, Nicole, Altena, Eveline, Bernardos, Rebecca, Brace, Selina, Broomandkhoshbacht, Nasreen, Callan, Kimberly, Candilio, Francesca, Culleton, Brendan, Curtis, Elizabeth, Demetz, Lea, Duffett Carlson, Kellie Sara, Edwards, Ceiridwen J., Fernandes, Daniel M., Foody, M. George B., Freilich, Suzanne, Goodchild, Helen, Kearns, Aisling, Lawson, Ann Marie, Lazaridis, Iosif, Mah, Matthew, Mallick, Swapan, Mandl, Kirsten, Micco, Adam, Michel, Megan, Bravo Morante, Guillermo, Oppenheimer, Jonas, Ozdogan, Kadir Toykan, Qiu, Lijun, Schattke, Constanze, Stewardson, Kristin, Workman, J. Noah, Zalzala, Fatma, Zhang, Zhao, Agusti, Bibiana, Allen, Tim, Almassy, Katalin, Amkreutz, Luc, Ash, Abigail, Baillif-Ducros, Christele, Barclay, Alistair, Bartosiewicz, László, Baxter, Katherine, Bernert, Zsolt, Blazek, Jan, Bodruzic, Mario, Boissinot, Philippe, Bonsall, Clive, Bradley, Pippa, Brittain, Marcus, Brookes, Alison, Brown, Fraser, Brown, Lisa, Brunning, Richard, Budd, Chelsea, Burmaz, Josip, Canet, Sylvain, Carnicero-Caceres, Silvia, Causevic-Bully, Morana, Chamberlain, Andrew, Chauvin, Sebastien, Clough, Sharon, Condic, Natalija, Coppa, Alfredo, Craig, Oliver, Cresnar, Matija, Cummings, Vicki, Czifra, Szabolcs, Danielisova, Alzbeta, Daniels, Robin, Davies, Alex, de Jersey, Philip, Deacon, Jody, Deminger, Csilla, Ditchfield, Peter W., Dizdar, Marko, Dobes, Miroslav, Dobisikova, Miluse, Domboroczki, Laszlo, Drinkall, Gail, Dukic, Ana, Ernee, Michal, Evans, Christopher, Evans, Jane, Fernandez-Gotz, Manuel, Filipovic, Slavica, Fitzpatrick, Andrew, Fokkens, Harry, Fowler, Chris, Fox, Allison, Gallina, Zsolt, Gamble, Michelle, Gonzalez Morales, Manuel R., Gonzalez-Rabanal, Borja, Green, Adrian, Gyenesei, Katalin, Habermehl, Diederick, Hajdu, Tamas, Hamilton, Derek, Harris, James, Hayden, Chris, Hendriks, Joep, Hernu, Benedicte, Hey, Gill, Hornak, Milan, Ilon, Gabor, Istvanovits, Eszter, Jones, Andy M., Blecic Kavur, Martina, Kazek, Kevin, Kenyon, Robert A., Khreisheh, Amal, Kiss, Viktoria, Kleijne, Jos, Knight, Mark, Kootker, Lisette M., Kovacs, Peter F., Kozubova, Anita, Kulcsar, Gabriella, Kulcsar, Valeria, Le Pennec, Christophe, Legge, Michael, Leivers, Matt, Loe, Louise, Lopez-Costas, Olalla, Lord, Tom, Los, Dzeni, Lyall, James, Marin-Arroyo, Ana B., Mason, Philip, Matosevic, Damir, Maxted, Andy, McIntyre, Lauren, McKinley, Jacqueline, McSweeney, Kathleen, Meijlink, Bernard, Mende, Balazs G., Mendusic, Marko, Metlicka, Milan, Meyer, Sophie, Mihovilic, Kristina, Milasinovic, Lidija, Minnitt, Steve, Moore, Joanna, Morley, Geoff, Mullan, Graham, Musilova, Margareta, Neil, Benjamin, Nicholls, Rebecca, Novak, Mario, Pala, Maria, Papworth, Martin, Paresys, Cecile, Patten, Ricky, Perkic, Domagoj, Pesti, Krisztina, Petit, Alba, Petrisakova, Katarina, Pichon, Coline, Pickard, Catriona, Pilling, Zoltan, Price, T. Douglas, Radovic, Sinisa, Redfern, Rebecca, Resutik, Branislav, Rhodes, Daniel T., Richards, Martin B., Roberts, Amy, Roefstra, Jean, Sankot, Pavel, Sefcakova, Alena, Sheridan, Alison, Skae, Sabine, Smolikova, Miroslava, Somogyi, Krisztina, Somogyvari, Agnes, Stephens, Mark, Szabo, Geza, Szecsenyi-Nagy, Anna, Szeniczey, Tamas, Tabor, Jonathan, Tanko, Karoly, Tavarez Maria, Clenis, Terry, Rachel, Terzan, Biba, Teschler-Nicola, Maria, Torres-Martinez, Jesus F., Trapp, Julien, Turle, Ross, Ujvari, Ferenc, van der Heiden, Menno, Veleminsky, Petr, Veselka, Barbara, Vytlacil, Zdenek, Waddington, Clive, Ware, Paula, Wilkinson, Paul, Wilson, Linda, Wiseman, Rob, Young, Eilidh, Zaninovic, Josko, Zitnan, Andrej, Lalueza-Fox, Carles, de Knijff, Peter, Barnes, Ian, Halkon, Peter, Thomas, Mark G., Kennett, Douglas J., Cunliffe, Barry, Lillie, Malcolm, Rohland, Nadin, Pinhasi, Ron, Armit, Ian, Reich, David, Patterson, Nick, Isakov, Michael, Booth, Thomas, Buster, Lindsey, Fischer, Claire-Elise, Olalde, Inigo, Ringbauer, Harald, Akbari, Ali, Cheronet, Olivia, Bleasdale, Madeleine, Adamski, Nicole, Altena, Eveline, Bernardos, Rebecca, Brace, Selina, Broomandkhoshbacht, Nasreen, Callan, Kimberly, Candilio, Francesca, Culleton, Brendan, Curtis, Elizabeth, Demetz, Lea, Duffett Carlson, Kellie Sara, Edwards, Ceiridwen J., Fernandes, Daniel M., Foody, M. George B., Freilich, Suzanne, Goodchild, Helen, Kearns, Aisling, Lawson, Ann Marie, Lazaridis, Iosif, Mah, Matthew, Mallick, Swapan, Mandl, Kirsten, Micco, Adam, Michel, Megan, Bravo Morante, Guillermo, Oppenheimer, Jonas, Ozdogan, Kadir Toykan, Qiu, Lijun, Schattke, Constanze, Stewardson, Kristin, Workman, J. Noah, Zalzala, Fatma, Zhang, Zhao, Agusti, Bibiana, Allen, Tim, Almassy, Katalin, Amkreutz, Luc, Ash, Abigail, Baillif-Ducros, Christele, Barclay, Alistair, Bartosiewicz, László, Baxter, Katherine, Bernert, Zsolt, Blazek, Jan, Bodruzic, Mario, Boissinot, Philippe, Bonsall, Clive, Bradley, Pippa, Brittain, Marcus, Brookes, Alison, Brown, Fraser, Brown, Lisa, Brunning, Richard, Budd, Chelsea, Burmaz, Josip, Canet, Sylvain, Carnicero-Caceres, Silvia, Causevic-Bully, Morana, Chamberlain, Andrew, Chauvin, Sebastien, Clough, Sharon, Condic, Natalija, Coppa, Alfredo, Craig, Oliver, Cresnar, Matija, Cummings, Vicki, Czifra, Szabolcs, Danielisova, Alzbeta, Daniels, Robin, Davies, Alex, de Jersey, Philip, Deacon, Jody, Deminger, Csilla, Ditchfield, Peter W., Dizdar, Marko, Dobes, Miroslav, Dobisikova, Miluse, Domboroczki, Laszlo, Drinkall, Gail, Dukic, Ana, Ernee, Michal, Evans, Christopher, Evans, Jane, Fernandez-Gotz, Manuel, Filipovic, Slavica, Fitzpatrick, Andrew, Fokkens, Harry, Fowler, Chris, Fox, Allison, Gallina, Zsolt, Gamble, Michelle, Gonzalez Morales, Manuel R., Gonzalez-Rabanal, Borja, Green, Adrian, Gyenesei, Katalin, Habermehl, Diederick, Hajdu, Tamas, Hamilton, Derek, Harris, James, Hayden, Chris, Hendriks, Joep, Hernu, Benedicte, Hey, Gill, Hornak, Milan, Ilon, Gabor, Istvanovits, Eszter, Jones, Andy M., Blecic Kavur, Martina, Kazek, Kevin, Kenyon, Robert A., Khreisheh, Amal, Kiss, Viktoria, Kleijne, Jos, Knight, Mark, Kootker, Lisette M., Kovacs, Peter F., Kozubova, Anita, Kulcsar, Gabriella, Kulcsar, Valeria, Le Pennec, Christophe, Legge, Michael, Leivers, Matt, Loe, Louise, Lopez-Costas, Olalla, Lord, Tom, Los, Dzeni, Lyall, James, Marin-Arroyo, Ana B., Mason, Philip, Matosevic, Damir, Maxted, Andy, McIntyre, Lauren, McKinley, Jacqueline, McSweeney, Kathleen, Meijlink, Bernard, Mende, Balazs G., Mendusic, Marko, Metlicka, Milan, Meyer, Sophie, Mihovilic, Kristina, Milasinovic, Lidija, Minnitt, Steve, Moore, Joanna, Morley, Geoff, Mullan, Graham, Musilova, Margareta, Neil, Benjamin, Nicholls, Rebecca, Novak, Mario, Pala, Maria, Papworth, Martin, Paresys, Cecile, Patten, Ricky, Perkic, Domagoj, Pesti, Krisztina, Petit, Alba, Petrisakova, Katarina, Pichon, Coline, Pickard, Catriona, Pilling, Zoltan, Price, T. Douglas, Radovic, Sinisa, Redfern, Rebecca, Resutik, Branislav, Rhodes, Daniel T., Richards, Martin B., Roberts, Amy, Roefstra, Jean, Sankot, Pavel, Sefcakova, Alena, Sheridan, Alison, Skae, Sabine, Smolikova, Miroslava, Somogyi, Krisztina, Somogyvari, Agnes, Stephens, Mark, Szabo, Geza, Szecsenyi-Nagy, Anna, Szeniczey, Tamas, Tabor, Jonathan, Tanko, Karoly, Tavarez Maria, Clenis, Terry, Rachel, Terzan, Biba, Teschler-Nicola, Maria, Torres-Martinez, Jesus F., Trapp, Julien, Turle, Ross, Ujvari, Ferenc, van der Heiden, Menno, Veleminsky, Petr, Veselka, Barbara, Vytlacil, Zdenek, Waddington, Clive, Ware, Paula, Wilkinson, Paul, Wilson, Linda, Wiseman, Rob, Young, Eilidh, Zaninovic, Josko, Zitnan, Andrej, Lalueza-Fox, Carles, de Knijff, Peter, Barnes, Ian, Halkon, Peter, Thomas, Mark G., Kennett, Douglas J., Cunliffe, Barry, Lillie, Malcolm, Rohland, Nadin, Pinhasi, Ron, Armit, Ian, and Reich, David
Abstract: Present-day people from England and Wales have more ancestry derived from early European farmers (EEF) than did people of the Early Bronze Age(1). To understand this, here we generated genome-wide data from 793 individuals, increasing data from the Middle to the Late Bronze Age and Iron Age in Britain by 12-fold, and western and central Europe by 3.5-fold. Between 1000 and 875 bc, EEF ancestry increased in southern Britain (England and Wales) but not northern Britain (Scotland) due to incorporation of migrants who arrived at this time and over previous centuries, and who were genetically most similar to ancient individuals from France. These migrants contributed about half the ancestry of people of England and Wales from the Iron Age, thereby creating a plausible vector for the spread of early Celtic languages into Britain. These patterns are part of a broader trend of EEF ancestry becoming more similar across central and western Europe in the Middle to the Late Bronze Age, coincident with archaeological evidence of intensified cultural exchange(2-6). There was comparatively less gene flow from continental Europe during the Iron Age, and the independent genetic trajectory in Britain is also reflected in the rise of the allele conferring lactase persistence to approximately 50% by this time compared to approximately 7% in central Europe where it rose rapidly in frequency only a millennium later. This suggests that dairy products were used in qualitatively different ways in Britain and in central Europe over this period.
Published: 2022
Full Text: View/download PDF

22. Data Protection and Cybersecurity Certification Activities and Schemes in the Energy Sector

Author: Nwankwo, Iheanyi, Stauch, Marc, Radoglou-Grammatikis, Panagiotis, Sarigiannidis, Panagiotis, Lazaridis, George, Drosou, Anastasios, Tzovaras, Dimitrios, Nwankwo, Iheanyi, Stauch, Marc, Radoglou-Grammatikis, Panagiotis, Sarigiannidis, Panagiotis, Lazaridis, George, Drosou, Anastasios, and Tzovaras, Dimitrios
Abstract: Cybersecurity concerns have been at the forefront of regulatory reform in the European Union (EU) recently. One of the outcomes of these reforms is the introduction of certification schemes for information and communication technology (ICT) products, services and processes, as well as for data processing operations concerning personal data. These schemes aim to provide an avenue for consumers to assess the compliance posture of organisations concerning the privacy and security of ICT products, services and processes. They also present manufacturers, providers and data controllers with the opportunity to demonstrate compliance with regulatory requirements through a verifiable third-party assessment. As these certification schemes are being developed, various sectors, including the electrical power and energy sector, will need to access the impact on their operations and plan towards successful implementation. Relying on a doctrinal method, this paper identifies relevant EU legal instruments on data protection and cybersecurity certification and their interpretation in order to examine their potential impact when applying certification schemes within the Electrical Power and Energy System (EPES) domain. The result suggests that the EPES domain employs different technologies and services from diverse areas, which can result in the application of several certification schemes within its environment, including horizontal, technological and sector-specific schemes. This has the potential for creating a complex constellation of implementation models and would require careful design to avoid proliferation and disincentivising of stakeholders. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
Published: 2022

23. Ancient DNA from Mesopotamia suggests distinct Pre-Pottery and Pottery Neolithic migrations into Anatolia

Author: ukupan broj autora 206, Lazaridis, Iosif, Alpaslan-Roodenberg, Songül, Acar, Ayşe, Açıkkol, Ayşen, Agelarakis, Anagnostis, Aghikyan, Levon, Antonović, Dragana, Borić, Dušan, Pinhasi, Ron, Reich, David, ukupan broj autora 206, Lazaridis, Iosif, Alpaslan-Roodenberg, Songül, Acar, Ayşe, Açıkkol, Ayşen, Agelarakis, Anagnostis, Aghikyan, Levon, Antonović, Dragana, Borić, Dušan, Pinhasi, Ron, and Reich, David
Abstract: We present the first ancient DNA data from the Pre-Pottery Neolithic of Mesopotamia (Southeastern Turkey and Northern Iraq), Cyprus, and the Northwestern Zagros, along with the first data from Neolithic Armenia. We show that these and neighboring populations were formed through admixture of pre-Neolithic sources related to Anatolian, Caucasus, and Levantine hunter-gatherers, forming a Neolithic continuum of ancestry mirroring the geography of West Asia. By analyzing Pre-Pottery and Pottery Neolithic populations of Anatolia, we show that the former were derived from admixture between Mesopotamian-related and local Epipaleolithic-related sources, but the latter experienced additional Levantine-related gene flow, thus documenting at least two pulses of migration from the Fertile Crescent heartland to the early farmers of Anatolia.
Published: 2022

24. A genetic probe into the ancient and medieval history of Southern Europe and West Asia

Author: rad ima 204 autora, Lazaridis, Iosif, Alpaslan-Roodenberg, Songül, Acar, Ayşe, Açıkkol, Ayşen, Agelarakis, Anagnostis, Aghikyan, Levon, Antonović, Dragana, Borić, Dušan, Pinhasi, Ron, Reich, David, rad ima 204 autora, Lazaridis, Iosif, Alpaslan-Roodenberg, Songül, Acar, Ayşe, Açıkkol, Ayşen, Agelarakis, Anagnostis, Aghikyan, Levon, Antonović, Dragana, Borić, Dušan, Pinhasi, Ron, and Reich, David
Abstract: Literary and archaeological sources have preserved a rich history of Southern Europe and West Asia since the Bronze Age that can be complemented by genetics. Mycenaean period elites in Greece did not differ from the general population and included both people with some steppe ancestry and others, like the Griffin Warrior, without it. Similarly, people in the central area of the Urartian Kingdom around Lake Van lacked the steppe ancestry characteristic of the kingdom’s northern provinces. Anatolia exhibited extraordinary continuity down to the Roman and Byzantine periods, with its people serving as the demographic core of much of the Roman Empire, including the city of Rome itself. During medieval times, migrations associated with Slavic and Turkic speakers profoundly affected the region.
Published: 2022

25. The genetic history of the Southern Arc : a bridge between West Asia and Europe

Author: Lazaridis, Iosif, Alpaslan-Roodenberg, Songül, Acar, Ayşe, Açıkkol, Ayşen, Antonović, Dragana, Borić, Dušan, Pinhasi, Ron, Reich, David, Lazaridis, Iosif, Alpaslan-Roodenberg, Songül, Acar, Ayşe, Açıkkol, Ayşen, Antonović, Dragana, Borić, Dušan, Pinhasi, Ron, and Reich, David
Abstract: By sequencing 727 ancient individuals from the Southern Arc (Anatolia and its neighbors in Southeastern Europe and West Asia) over 10,000 years, we contextualize its Chalcolithic period and Bronze Age (about 5000 to 1000 BCE), when extensive gene flow entangled it with the Eurasian steppe. Two streams of migration transmitted Caucasus and Anatolian/Levantine ancestry northward, and the Yamnaya pastoralists, formed on the steppe, then spread southward into the Balkans and across the Caucasus into Armenia, where they left numerous patrilineal descendants. Anatolia was transformed by intra–West Asian gene flow, with negligible impact of the later Yamnaya migrations. This contrasts with all other regions where Indo-European languages were spoken, suggesting that the homeland of the Indo-Anatolian language family was in West Asia, with only secondary dispersals of non-Anatolian Indo-Europeans from the steppe.
Published: 2022

26. Ancient DNA from Mesopotamia suggests distinct Pre-Pottery and Pottery Neolithic migrations into Anatolia

Author: Lazaridis, Iosif, Alpaslan-Roodenberg, Songül, Acar, Ayşe, Açıkkol, Ayşen, Agelarakis, Anagnostis, Aghikyan, Levon, Akyüz, Uğur, Andreeva, Desislava, Andrijašević, Gojko, Antonović, Dragana, Armit, Ian, Atmaca, Alper, Avetisyan, Pavel, Aytek, Ahmet İhsan, Bacvarov, Krum, Badalyan, Ruben, Bakardzhiev, Stefan, Balen, Jacqueline, Bejko, Lorenc, Bernardos, Rebecca, Bertsatos, Andreas, Biber, Hanifi, Bilir, Ahmet, Bodružić, Mario, Bonogofsky, Michelle, Bonsall, Clive, Borić, Dušan, Borovinić, Nikola, Bravo Morante, Guillermo, Buttinger, Katharina, Callan, Kim, Candilio, Francesca, Carić, Mario, Cheronet, Olivia, Chohadzhiev, Stefan, Chovalopoulou, Maria-Eleni, Chryssoulaki, Stella, Ciobanu, Ion, Čondić, Natalija, Constantinescu, Mihai, Cristiani, Emanuela, Culleton, Brendan J., Curtis, Elizabeth, Davis, Jack, Demcenco, Tatiana I., Dergachev, Valentin, Derin, Zafer, Deskaj, Sylvia, Devejyan, Seda, Djordjević, Vojislav, Duffett Carlson, Kellie Sara, Eccles, Laurie R., Elenski, Nedko, Engin, Atilla, Erdoğan, Nihat, Erir-Pazarcı, Sabiha, Fernandes, Daniel M., Ferry, Matthew, Freilich, Suzanne, Frînculeasa, Alin, Galaty, Michael L., Gamarra, Beatriz, Gasparyan, Boris, Gaydarska, Bisserka, Genç, Elif, Gültekin, Timur, Gündüz, Serkan, Hajdu, Tamás, Heyd, Volker, Hobosyan, Suren, Hovhannisyan, Nelli, Iliev, Iliya, Iliev, Lora, Iliev, Stanislav, İvgin, İlkay, Janković, Ivor, Jovanova, Lence, Karkanas, Panagiotis, Kavaz-Kındığılı, Berna, Kaya, Esra Hilal, Keating, Denise, Kennett, Douglas J., Deniz Kesici, Seda, Khudaverdyan, Anahit, Kiss, Krisztián, Kılıç, Sinan, Klostermann, Paul, Kostak Boca Negra Valdes, Sinem, Kovačević, Saša, Krenz-Niedbała, Marta, Krznarić Škrivanko, Maja, Kurti, Rovena, Kuzman, Pasko, Lawson, Ann Marie, Lazar, Catalin, Leshtakov, Krassimir, Levy, Thomas E., Liritzis, Ioannis, Lorentz, Kirsi O., Łukasik, Sylwia, Mah, Matthew, Mallick, Swapan, Mandl, Kirsten, Martirosyan-Olshansky, Kristine, Matthews, Roger, Matthews, Wendy, McSweeney, Kathleen, Melikyan, Varduhi, Micco, Adam, Michel, Megan, Milašinović, Lidija, Mittnik, Alissa, Monge, Janet M., Nekhrizov, Georgi, Nicholls, Rebecca, Nikitin, Alexey G., Nikolov, Vassil, Novak, Mario, Olalde, Iñigo, Oppenheimer, Jonas, Osterholtz, Anna, Özdemir, Celal, Özdoğan, Kadir Toykan, Öztürk, Nurettin, Papadimitriou, Nikos, Papakonstantinou, Niki, Papathanasiou, Anastasia, Paraman, Lujana, Paskary, Evgeny G., Patterson, Nick, Petrakiev, Ilian, Petrosyan, Levon, Petrova, Vanya, Philippa-Touchais, Anna, Piliposyan, Ashot, Pocuca Kuzman, Nada, Potrebica, Hrvoje, Preda-Bălănică, Bianca, Premužić, Zrinka, Price, T. Douglas, Qiu, Lijun, Radović, Siniša, Raeuf Aziz, Kamal, Rajić Šikanjić, Petra, Rasheed Raheem, Kamal, Razumov, Sergei, Richardson, Amy, Roodenberg, Jacob, Ruka, Rudenc, Russeva, Victoria, Şahin, Mustafa, Şarbak, Ayşegül, Savaş, Emre, Schattke, Constanze, Schepartz, Lynne, Selçuk, Tayfun, Sevim-Erol, Ayla, Shamoon-Pour, Michel, Shephard, Henry M., Sideris, Athanasios, Simalcsik, Angela, Simonyan, Hakob, Sinika, Vitalij, Sirak, Kendra, Sirbu, Ghenadie, Šlaus, Mario, Soficaru, Andrei, Söğüt, Bilal, Sołtysiak, Arkadiusz, Sönmez-Sözer, Çilem, Stathi, Maria, Steskal, Martin, Stewardson, Kristin, Stocker, Sharon, Suata-Alpaslan, Fadime, Suvorov, Alexander, Szécsényi-Nagy, Anna, Szeniczey, Tamás, Telnov, Nikolai, Temov, Strahil, Todorova, Nadezhda, Tota, Ulsi, Touchais, Gilles, Triantaphyllou, Sevi, Türker, Atila, Ugarković, Marina, Valchev, Todor, Veljanovska, Fanica, Videvski, Zlatko, Virag, Cristian, Wagner, Anna, Walsh, Samantha, Włodarczak, Piotr, Workman, J. Noah, Yardumian, Aram, Yarovoy, Evgenii, Yavuz, Alper Yener, Yılmaz, Hakan, Zalzala, Fatma, Zettl, Anna, Zhang, Zhao, Çavuşoğlu, Rafet, Rohland, Nadin, Pinhasi, Ron, Reich, David, Lazaridis, Iosif, Alpaslan-Roodenberg, Songül, Acar, Ayşe, Açıkkol, Ayşen, Agelarakis, Anagnostis, Aghikyan, Levon, Akyüz, Uğur, Andreeva, Desislava, Andrijašević, Gojko, Antonović, Dragana, Armit, Ian, Atmaca, Alper, Avetisyan, Pavel, Aytek, Ahmet İhsan, Bacvarov, Krum, Badalyan, Ruben, Bakardzhiev, Stefan, Balen, Jacqueline, Bejko, Lorenc, Bernardos, Rebecca, Bertsatos, Andreas, Biber, Hanifi, Bilir, Ahmet, Bodružić, Mario, Bonogofsky, Michelle, Bonsall, Clive, Borić, Dušan, Borovinić, Nikola, Bravo Morante, Guillermo, Buttinger, Katharina, Callan, Kim, Candilio, Francesca, Carić, Mario, Cheronet, Olivia, Chohadzhiev, Stefan, Chovalopoulou, Maria-Eleni, Chryssoulaki, Stella, Ciobanu, Ion, Čondić, Natalija, Constantinescu, Mihai, Cristiani, Emanuela, Culleton, Brendan J., Curtis, Elizabeth, Davis, Jack, Demcenco, Tatiana I., Dergachev, Valentin, Derin, Zafer, Deskaj, Sylvia, Devejyan, Seda, Djordjević, Vojislav, Duffett Carlson, Kellie Sara, Eccles, Laurie R., Elenski, Nedko, Engin, Atilla, Erdoğan, Nihat, Erir-Pazarcı, Sabiha, Fernandes, Daniel M., Ferry, Matthew, Freilich, Suzanne, Frînculeasa, Alin, Galaty, Michael L., Gamarra, Beatriz, Gasparyan, Boris, Gaydarska, Bisserka, Genç, Elif, Gültekin, Timur, Gündüz, Serkan, Hajdu, Tamás, Heyd, Volker, Hobosyan, Suren, Hovhannisyan, Nelli, Iliev, Iliya, Iliev, Lora, Iliev, Stanislav, İvgin, İlkay, Janković, Ivor, Jovanova, Lence, Karkanas, Panagiotis, Kavaz-Kındığılı, Berna, Kaya, Esra Hilal, Keating, Denise, Kennett, Douglas J., Deniz Kesici, Seda, Khudaverdyan, Anahit, Kiss, Krisztián, Kılıç, Sinan, Klostermann, Paul, Kostak Boca Negra Valdes, Sinem, Kovačević, Saša, Krenz-Niedbała, Marta, Krznarić Škrivanko, Maja, Kurti, Rovena, Kuzman, Pasko, Lawson, Ann Marie, Lazar, Catalin, Leshtakov, Krassimir, Levy, Thomas E., Liritzis, Ioannis, Lorentz, Kirsi O., Łukasik, Sylwia, Mah, Matthew, Mallick, Swapan, Mandl, Kirsten, Martirosyan-Olshansky, Kristine, Matthews, Roger, Matthews, Wendy, McSweeney, Kathleen, Melikyan, Varduhi, Micco, Adam, Michel, Megan, Milašinović, Lidija, Mittnik, Alissa, Monge, Janet M., Nekhrizov, Georgi, Nicholls, Rebecca, Nikitin, Alexey G., Nikolov, Vassil, Novak, Mario, Olalde, Iñigo, Oppenheimer, Jonas, Osterholtz, Anna, Özdemir, Celal, Özdoğan, Kadir Toykan, Öztürk, Nurettin, Papadimitriou, Nikos, Papakonstantinou, Niki, Papathanasiou, Anastasia, Paraman, Lujana, Paskary, Evgeny G., Patterson, Nick, Petrakiev, Ilian, Petrosyan, Levon, Petrova, Vanya, Philippa-Touchais, Anna, Piliposyan, Ashot, Pocuca Kuzman, Nada, Potrebica, Hrvoje, Preda-Bălănică, Bianca, Premužić, Zrinka, Price, T. Douglas, Qiu, Lijun, Radović, Siniša, Raeuf Aziz, Kamal, Rajić Šikanjić, Petra, Rasheed Raheem, Kamal, Razumov, Sergei, Richardson, Amy, Roodenberg, Jacob, Ruka, Rudenc, Russeva, Victoria, Şahin, Mustafa, Şarbak, Ayşegül, Savaş, Emre, Schattke, Constanze, Schepartz, Lynne, Selçuk, Tayfun, Sevim-Erol, Ayla, Shamoon-Pour, Michel, Shephard, Henry M., Sideris, Athanasios, Simalcsik, Angela, Simonyan, Hakob, Sinika, Vitalij, Sirak, Kendra, Sirbu, Ghenadie, Šlaus, Mario, Soficaru, Andrei, Söğüt, Bilal, Sołtysiak, Arkadiusz, Sönmez-Sözer, Çilem, Stathi, Maria, Steskal, Martin, Stewardson, Kristin, Stocker, Sharon, Suata-Alpaslan, Fadime, Suvorov, Alexander, Szécsényi-Nagy, Anna, Szeniczey, Tamás, Telnov, Nikolai, Temov, Strahil, Todorova, Nadezhda, Tota, Ulsi, Touchais, Gilles, Triantaphyllou, Sevi, Türker, Atila, Ugarković, Marina, Valchev, Todor, Veljanovska, Fanica, Videvski, Zlatko, Virag, Cristian, Wagner, Anna, Walsh, Samantha, Włodarczak, Piotr, Workman, J. Noah, Yardumian, Aram, Yarovoy, Evgenii, Yavuz, Alper Yener, Yılmaz, Hakan, Zalzala, Fatma, Zettl, Anna, Zhang, Zhao, Çavuşoğlu, Rafet, Rohland, Nadin, Pinhasi, Ron, and Reich, David
Abstract: We present the first ancient DNA data from the Pre-Pottery Neolithic of Mesopotamia (Southeastern Turkey and Northern Iraq), Cyprus, and the Northwestern Zagros, along with the first data from Neolithic Armenia. We show that these and neighboring populations were formed through admixture of pre-Neolithic sources related to Anatolian, Caucasus, and Levantine hunter-gatherers, forming a Neolithic continuum of ancestry mirroring the geography of West Asia. By analyzing Pre-Pottery and Pottery Neolithic populations of Anatolia, we show that the former were derived from admixture between Mesopotamian-related and local Epipaleolithic-related sources, but the latter experienced additional Levantine-related gene flow, thus documenting at least two pulses of migration from the Fertile Crescent heartland to the early farmers of Anatolia.
Published: 2022

27. Ancient DNA from Mesopotamia suggests distinct Pre-Pottery and Pottery Neolithic migrations into Anatolia

Author: Lazaridis, Iosif, Alpaslan-Roodenberg, Songül, Acar, Ayşe, Açıkkol, Ayşen, Agelarakis, Anagnostis, Aghikyan, Levon, Akyüz, Uğur, Andreeva, Desislava, Andrijašević, Gojko, Antonović, Dragana, Armit, Ian, Atmaca, Alper, Avetisyan, Pavel, Aytek, Ahmet İhsan, Bacvarov, Krum, Badalyan, Ruben, Bakardzhiev, Stefan, Balen, Jacqueline, Bejko, Lorenc, Bernardos, Rebecca, Bertsatos, Andreas, Biber, Hanifi, Bilir, Ahmet, Bodružić, Mario, Bonogofsky, Michelle, Bonsall, Clive, Borić, Dušan, Borovinić, Nikola, Bravo Morante, Guillermo, Buttinger, Katharina, Callan, Kim, Candilio, Francesca, Carić, Mario, Cheronet, Olivia, Chohadzhiev, Stefan, Chovalopoulou, Maria-Eleni, Chryssoulaki, Stella, Ciobanu, Ion, Čondić, Natalija, Constantinescu, Mihai, Cristiani, Emanuela, Culleton, Brendan J., Curtis, Elizabeth, Davis, Jack, Demcenco, Tatiana I., Dergachev, Valentin, Derin, Zafer, Deskaj, Sylvia, Devejyan, Seda, Djordjević, Vojislav, Duffett Carlson, Kellie Sara, Eccles, Laurie R., Elenski, Nedko, Engin, Atilla, Erdoğan, Nihat, Erir-Pazarcı, Sabiha, Fernandes, Daniel M., Ferry, Matthew, Freilich, Suzanne, Frînculeasa, Alin, Galaty, Michael L., Gamarra, Beatriz, Gasparyan, Boris, Gaydarska, Bisserka, Genç, Elif, Gültekin, Timur, Gündüz, Serkan, Hajdu, Tamás, Heyd, Volker, Hobosyan, Suren, Hovhannisyan, Nelli, Iliev, Iliya, Iliev, Lora, Iliev, Stanislav, İvgin, İlkay, Janković, Ivor, Jovanova, Lence, Karkanas, Panagiotis, Kavaz-Kındığılı, Berna, Kaya, Esra Hilal, Keating, Denise, Kennett, Douglas J., Deniz Kesici, Seda, Khudaverdyan, Anahit, Kiss, Krisztián, Kılıç, Sinan, Klostermann, Paul, Kostak Boca Negra Valdes, Sinem, Kovačević, Saša, Krenz-Niedbała, Marta, Krznarić Škrivanko, Maja, Kurti, Rovena, Kuzman, Pasko, Lawson, Ann Marie, Lazar, Catalin, Leshtakov, Krassimir, Levy, Thomas E., Liritzis, Ioannis, Lorentz, Kirsi O., Łukasik, Sylwia, Mah, Matthew, Mallick, Swapan, Mandl, Kirsten, Martirosyan-Olshansky, Kristine, Matthews, Roger, Matthews, Wendy, McSweeney, Kathleen, Melikyan, Varduhi, Micco, Adam, Michel, Megan, Milašinović, Lidija, Mittnik, Alissa, Monge, Janet M., Nekhrizov, Georgi, Nicholls, Rebecca, Nikitin, Alexey G., Nikolov, Vassil, Novak, Mario, Olalde, Iñigo, Oppenheimer, Jonas, Osterholtz, Anna, Özdemir, Celal, Özdoğan, Kadir Toykan, Öztürk, Nurettin, Papadimitriou, Nikos, Papakonstantinou, Niki, Papathanasiou, Anastasia, Paraman, Lujana, Paskary, Evgeny G., Patterson, Nick, Petrakiev, Ilian, Petrosyan, Levon, Petrova, Vanya, Philippa-Touchais, Anna, Piliposyan, Ashot, Pocuca Kuzman, Nada, Potrebica, Hrvoje, Preda-Bălănică, Bianca, Premužić, Zrinka, Price, T. Douglas, Qiu, Lijun, Radović, Siniša, Raeuf Aziz, Kamal, Rajić Šikanjić, Petra, Rasheed Raheem, Kamal, Razumov, Sergei, Richardson, Amy, Roodenberg, Jacob, Ruka, Rudenc, Russeva, Victoria, Şahin, Mustafa, Şarbak, Ayşegül, Savaş, Emre, Schattke, Constanze, Schepartz, Lynne, Selçuk, Tayfun, Sevim-Erol, Ayla, Shamoon-Pour, Michel, Shephard, Henry M., Sideris, Athanasios, Simalcsik, Angela, Simonyan, Hakob, Sinika, Vitalij, Sirak, Kendra, Sirbu, Ghenadie, Šlaus, Mario, Soficaru, Andrei, Söğüt, Bilal, Sołtysiak, Arkadiusz, Sönmez-Sözer, Çilem, Stathi, Maria, Steskal, Martin, Stewardson, Kristin, Stocker, Sharon, Suata-Alpaslan, Fadime, Suvorov, Alexander, Szécsényi-Nagy, Anna, Szeniczey, Tamás, Telnov, Nikolai, Temov, Strahil, Todorova, Nadezhda, Tota, Ulsi, Touchais, Gilles, Triantaphyllou, Sevi, Türker, Atila, Ugarković, Marina, Valchev, Todor, Veljanovska, Fanica, Videvski, Zlatko, Virag, Cristian, Wagner, Anna, Walsh, Samantha, Włodarczak, Piotr, Workman, J. Noah, Yardumian, Aram, Yarovoy, Evgenii, Yavuz, Alper Yener, Yılmaz, Hakan, Zalzala, Fatma, Zettl, Anna, Zhang, Zhao, Çavuşoğlu, Rafet, Rohland, Nadin, Pinhasi, Ron, Reich, David, Lazaridis, Iosif, Alpaslan-Roodenberg, Songül, Acar, Ayşe, Açıkkol, Ayşen, Agelarakis, Anagnostis, Aghikyan, Levon, Akyüz, Uğur, Andreeva, Desislava, Andrijašević, Gojko, Antonović, Dragana, Armit, Ian, Atmaca, Alper, Avetisyan, Pavel, Aytek, Ahmet İhsan, Bacvarov, Krum, Badalyan, Ruben, Bakardzhiev, Stefan, Balen, Jacqueline, Bejko, Lorenc, Bernardos, Rebecca, Bertsatos, Andreas, Biber, Hanifi, Bilir, Ahmet, Bodružić, Mario, Bonogofsky, Michelle, Bonsall, Clive, Borić, Dušan, Borovinić, Nikola, Bravo Morante, Guillermo, Buttinger, Katharina, Callan, Kim, Candilio, Francesca, Carić, Mario, Cheronet, Olivia, Chohadzhiev, Stefan, Chovalopoulou, Maria-Eleni, Chryssoulaki, Stella, Ciobanu, Ion, Čondić, Natalija, Constantinescu, Mihai, Cristiani, Emanuela, Culleton, Brendan J., Curtis, Elizabeth, Davis, Jack, Demcenco, Tatiana I., Dergachev, Valentin, Derin, Zafer, Deskaj, Sylvia, Devejyan, Seda, Djordjević, Vojislav, Duffett Carlson, Kellie Sara, Eccles, Laurie R., Elenski, Nedko, Engin, Atilla, Erdoğan, Nihat, Erir-Pazarcı, Sabiha, Fernandes, Daniel M., Ferry, Matthew, Freilich, Suzanne, Frînculeasa, Alin, Galaty, Michael L., Gamarra, Beatriz, Gasparyan, Boris, Gaydarska, Bisserka, Genç, Elif, Gültekin, Timur, Gündüz, Serkan, Hajdu, Tamás, Heyd, Volker, Hobosyan, Suren, Hovhannisyan, Nelli, Iliev, Iliya, Iliev, Lora, Iliev, Stanislav, İvgin, İlkay, Janković, Ivor, Jovanova, Lence, Karkanas, Panagiotis, Kavaz-Kındığılı, Berna, Kaya, Esra Hilal, Keating, Denise, Kennett, Douglas J., Deniz Kesici, Seda, Khudaverdyan, Anahit, Kiss, Krisztián, Kılıç, Sinan, Klostermann, Paul, Kostak Boca Negra Valdes, Sinem, Kovačević, Saša, Krenz-Niedbała, Marta, Krznarić Škrivanko, Maja, Kurti, Rovena, Kuzman, Pasko, Lawson, Ann Marie, Lazar, Catalin, Leshtakov, Krassimir, Levy, Thomas E., Liritzis, Ioannis, Lorentz, Kirsi O., Łukasik, Sylwia, Mah, Matthew, Mallick, Swapan, Mandl, Kirsten, Martirosyan-Olshansky, Kristine, Matthews, Roger, Matthews, Wendy, McSweeney, Kathleen, Melikyan, Varduhi, Micco, Adam, Michel, Megan, Milašinović, Lidija, Mittnik, Alissa, Monge, Janet M., Nekhrizov, Georgi, Nicholls, Rebecca, Nikitin, Alexey G., Nikolov, Vassil, Novak, Mario, Olalde, Iñigo, Oppenheimer, Jonas, Osterholtz, Anna, Özdemir, Celal, Özdoğan, Kadir Toykan, Öztürk, Nurettin, Papadimitriou, Nikos, Papakonstantinou, Niki, Papathanasiou, Anastasia, Paraman, Lujana, Paskary, Evgeny G., Patterson, Nick, Petrakiev, Ilian, Petrosyan, Levon, Petrova, Vanya, Philippa-Touchais, Anna, Piliposyan, Ashot, Pocuca Kuzman, Nada, Potrebica, Hrvoje, Preda-Bălănică, Bianca, Premužić, Zrinka, Price, T. Douglas, Qiu, Lijun, Radović, Siniša, Raeuf Aziz, Kamal, Rajić Šikanjić, Petra, Rasheed Raheem, Kamal, Razumov, Sergei, Richardson, Amy, Roodenberg, Jacob, Ruka, Rudenc, Russeva, Victoria, Şahin, Mustafa, Şarbak, Ayşegül, Savaş, Emre, Schattke, Constanze, Schepartz, Lynne, Selçuk, Tayfun, Sevim-Erol, Ayla, Shamoon-Pour, Michel, Shephard, Henry M., Sideris, Athanasios, Simalcsik, Angela, Simonyan, Hakob, Sinika, Vitalij, Sirak, Kendra, Sirbu, Ghenadie, Šlaus, Mario, Soficaru, Andrei, Söğüt, Bilal, Sołtysiak, Arkadiusz, Sönmez-Sözer, Çilem, Stathi, Maria, Steskal, Martin, Stewardson, Kristin, Stocker, Sharon, Suata-Alpaslan, Fadime, Suvorov, Alexander, Szécsényi-Nagy, Anna, Szeniczey, Tamás, Telnov, Nikolai, Temov, Strahil, Todorova, Nadezhda, Tota, Ulsi, Touchais, Gilles, Triantaphyllou, Sevi, Türker, Atila, Ugarković, Marina, Valchev, Todor, Veljanovska, Fanica, Videvski, Zlatko, Virag, Cristian, Wagner, Anna, Walsh, Samantha, Włodarczak, Piotr, Workman, J. Noah, Yardumian, Aram, Yarovoy, Evgenii, Yavuz, Alper Yener, Yılmaz, Hakan, Zalzala, Fatma, Zettl, Anna, Zhang, Zhao, Çavuşoğlu, Rafet, Rohland, Nadin, Pinhasi, Ron, and Reich, David
Abstract: We present the first ancient DNA data from the Pre-Pottery Neolithic of Mesopotamia (Southeastern Turkey and Northern Iraq), Cyprus, and the Northwestern Zagros, along with the first data from Neolithic Armenia. We show that these and neighboring populations were formed through admixture of pre-Neolithic sources related to Anatolian, Caucasus, and Levantine hunter-gatherers, forming a Neolithic continuum of ancestry mirroring the geography of West Asia. By analyzing Pre-Pottery and Pottery Neolithic populations of Anatolia, we show that the former were derived from admixture between Mesopotamian-related and local Epipaleolithic-related sources, but the latter experienced additional Levantine-related gene flow, thus documenting at least two pulses of migration from the Fertile Crescent heartland to the early farmers of Anatolia.
Published: 2022

28. A genetic probe into the ancient and medieval history of Southern Europe and West Asia

Author: Lazaridis, Iosif, Alpaslan-Roodenberg, Songul, Acar, Ayse, Acikkol, Aysen, Agelarakis, Anagnostis, Aghikyan, Levon, Akyuz, Ugur, Andreeva, Desislava, Andrijasevic, Gojko, Anatonovic, Dragana, Armit, Ian, Atmaca, Alper, Avetisyan, Alper, Avetisyan, Pavel, Aytek, Ahmet Ihsan, Bacvarov, Krum, Badalyan, Ruben, Bakardzhiev, Stefan, Balen, Jacqueline, Bejko, Lorenc, Bernardos, Rebecca, Bertsatos, Andreas, Biber, Hanifi, Bilir, Ahmet, Brodruzic, Mario, Bonogofsky, Michelle, Bonsall, Clive, Boric, Dusan, Borovinic, Nikola, Morante, Guillermo Bravo, Buttinger, Katharina, Callan, Kim, Candilio, Francesca, Caric, Mario, Cheronet, Olivia, Chohadzhiev, Stefan, Chovalopoulou, Maria-Eleni, Chryssoulaki, Stella, Ciobanu, Ion, Condic, Natalija, Constantienescu, Mihai, Cristiani, Emanuela, Culleton, Brendan J, Curtis, Elizabeth, Davis, Jack, Davtyan, Ruben, Demcenco, Tatiana I, Dergachev, Valentin, Derin, Zafer, Deskaj, Sylvia, Devejyan, Seda, Djordjevic, Vojislav, Duffett Carlson, Kellie Sara, Eccles, Laurie R, Elenski, Nedko, Engin, Atilla, Erdogan, Nihat, Erir-Pazarci, Sabiha, Fernandes, Daniel M, Ferry, Matthew, Freilich, Suzanne, Frinculeasa, Alin, Galaty, Michael L, Gamarra, Beatriz, Gasparyan, Boris, Gaydarska, Bisserka, Genc, Elif, Gultekin, Timur, Gunduz, Serkan, Hajdu, Tamas, Heyd, Volker, Hobosyan, Suren, Hovhannisyan, Nelli, Iliev, Ilya, Iliev, Stanislav, Ivgin, Ilkay, Jankovic, Ivor, Jovanova, Lence, Karkanas, Panagiotis, Kavaz-Kindigili, Berna, Kaya, Esra Hilal, Keating, Denise, Kennett, Douglas J, Kesici, Seda Deniz, Khudaverdyan, Anahit, Kiss, Krisztian, Kilic, Sinan, Klostermann, Paul, Negra Valdes, Sniem Kostak Boca, Kovacevic, Sasa, Krenz-Niedbala, Marta, Skrivanko, Maja Krznaric, Kurti, Rovena, Kuzman, Pasko, Lawson, Ann Marie, Lazar, Catalin, Leshtakov, Krassimir, Levy, Thomas E, Liritzis, Ioannis, Lorentz, Kirsi O, Lukasik, Sylwia, Mah, Matthew, Mallick, Swapan, Mandl, Kirsten, Martirosyan-Olshansky, Kristine, Matthews, Roger, Matthews, Wendy, McSweeney, Kathleen, Melikyan, Varduhi, Micco, Adam, Michel, Megan, Milasinovic, Lidija, Mittnik, Alissa, Monge, Janet M, Nekhrizov, Georgi, Nicholls, Rebecca, Nikitin, Alexey G, Nikolov, Vassil, Novak, Mario, Olalde, Inigo, Oppenheimer, Jonas, Osterholtz, Anna, Ozdemir, Celal, Ozdogan, Kadir Toykan, Ozturk, Nurettin, Papadimitriou, Nikos, Papakonstantinou, Niki, Papathanasiou, Anastasia, Paraman, Lujana, Paskary, Evgeny G, Patterson, Nick, Petrakiev, Ilian, Petrosyan, Levon, Petrova, Vanya, Phillippa-Touchais, Anna, Piliposyan, Ashot, Pocuca Kuzman, Nada, Potrebica, Hrvoje, Preda-Balancia, Bianca, Premuzic, Zrinka, Price, T Douglas, Qiu, Lijun, Radovic, Sinisa, Raeuf Aziz, Kamal, Rajic Sikanjic, Petra, Rasheed Raheem, Kamal, Razumov, Sergei, Richardson, Amy, Roodenberg, Jacob, Ruka, Rudenc, Rasseva, Victoria, Sahin, Mustafa, Sarbak, Aysegul, Savas, Emre, Schattke, Constanze, Schepartz, Lynne, Selcuk, Tayfun, Sevim-Erol, Ayla, Shamoon-Pour, Michel, Shephard, Henry M, Sideris, Athanasios, Simalcsik, Angela, Simonyan, Hakob, Sinika, Vitalij, Sirak, Kendra, Sirbu, Ghenadie, Slaus, Mario, Soficaru, Andrei, Sogut, Bilal, Soltysiak, Arkadiusz, Sonmez-Sozer, Cilem, Stathi, Maria, Steskal, Martin, Stewardson, Kristin, Stocker, Sharon, Suata-Alpaslan, Fadime, Suvorov, Alexander, Szecsenyi-Nagy, Anna, Szeniczey, Tamas, Telnov, Nikolai, Temov, Strahil, Todorova, Nadezhda, Tota, Ulsi, Touchais, Gilles, Triantaphyllou, Sevi, Turker, Atila, Ugarkovic, Marina, Valchev, Todor, Veljanovska, Fancia, Videvski, Zlatko, Virag, Christian, Wagner, Anna, Walsh, Samantha, Wlodarczak, Piotr, Workman, J Noah, Yardumian, Aram, Yarovoy, Evgenii, Yavuz, Alper Yener, Yilmaz, Hakan, Zalzala, Fatma, Zettl, Anna, Zhang, Zhao, Cavusoglu, Rafet, Rohland, Nadin, Pinhasi, Ron, Reich, David, Lazaridis, Iosif, Alpaslan-Roodenberg, Songul, Acar, Ayse, Acikkol, Aysen, Agelarakis, Anagnostis, Aghikyan, Levon, Akyuz, Ugur, Andreeva, Desislava, Andrijasevic, Gojko, Anatonovic, Dragana, Armit, Ian, Atmaca, Alper, Avetisyan, Alper, Avetisyan, Pavel, Aytek, Ahmet Ihsan, Bacvarov, Krum, Badalyan, Ruben, Bakardzhiev, Stefan, Balen, Jacqueline, Bejko, Lorenc, Bernardos, Rebecca, Bertsatos, Andreas, Biber, Hanifi, Bilir, Ahmet, Brodruzic, Mario, Bonogofsky, Michelle, Bonsall, Clive, Boric, Dusan, Borovinic, Nikola, Morante, Guillermo Bravo, Buttinger, Katharina, Callan, Kim, Candilio, Francesca, Caric, Mario, Cheronet, Olivia, Chohadzhiev, Stefan, Chovalopoulou, Maria-Eleni, Chryssoulaki, Stella, Ciobanu, Ion, Condic, Natalija, Constantienescu, Mihai, Cristiani, Emanuela, Culleton, Brendan J, Curtis, Elizabeth, Davis, Jack, Davtyan, Ruben, Demcenco, Tatiana I, Dergachev, Valentin, Derin, Zafer, Deskaj, Sylvia, Devejyan, Seda, Djordjevic, Vojislav, Duffett Carlson, Kellie Sara, Eccles, Laurie R, Elenski, Nedko, Engin, Atilla, Erdogan, Nihat, Erir-Pazarci, Sabiha, Fernandes, Daniel M, Ferry, Matthew, Freilich, Suzanne, Frinculeasa, Alin, Galaty, Michael L, Gamarra, Beatriz, Gasparyan, Boris, Gaydarska, Bisserka, Genc, Elif, Gultekin, Timur, Gunduz, Serkan, Hajdu, Tamas, Heyd, Volker, Hobosyan, Suren, Hovhannisyan, Nelli, Iliev, Ilya, Iliev, Stanislav, Ivgin, Ilkay, Jankovic, Ivor, Jovanova, Lence, Karkanas, Panagiotis, Kavaz-Kindigili, Berna, Kaya, Esra Hilal, Keating, Denise, Kennett, Douglas J, Kesici, Seda Deniz, Khudaverdyan, Anahit, Kiss, Krisztian, Kilic, Sinan, Klostermann, Paul, Negra Valdes, Sniem Kostak Boca, Kovacevic, Sasa, Krenz-Niedbala, Marta, Skrivanko, Maja Krznaric, Kurti, Rovena, Kuzman, Pasko, Lawson, Ann Marie, Lazar, Catalin, Leshtakov, Krassimir, Levy, Thomas E, Liritzis, Ioannis, Lorentz, Kirsi O, Lukasik, Sylwia, Mah, Matthew, Mallick, Swapan, Mandl, Kirsten, Martirosyan-Olshansky, Kristine, Matthews, Roger, Matthews, Wendy, McSweeney, Kathleen, Melikyan, Varduhi, Micco, Adam, Michel, Megan, Milasinovic, Lidija, Mittnik, Alissa, Monge, Janet M, Nekhrizov, Georgi, Nicholls, Rebecca, Nikitin, Alexey G, Nikolov, Vassil, Novak, Mario, Olalde, Inigo, Oppenheimer, Jonas, Osterholtz, Anna, Ozdemir, Celal, Ozdogan, Kadir Toykan, Ozturk, Nurettin, Papadimitriou, Nikos, Papakonstantinou, Niki, Papathanasiou, Anastasia, Paraman, Lujana, Paskary, Evgeny G, Patterson, Nick, Petrakiev, Ilian, Petrosyan, Levon, Petrova, Vanya, Phillippa-Touchais, Anna, Piliposyan, Ashot, Pocuca Kuzman, Nada, Potrebica, Hrvoje, Preda-Balancia, Bianca, Premuzic, Zrinka, Price, T Douglas, Qiu, Lijun, Radovic, Sinisa, Raeuf Aziz, Kamal, Rajic Sikanjic, Petra, Rasheed Raheem, Kamal, Razumov, Sergei, Richardson, Amy, Roodenberg, Jacob, Ruka, Rudenc, Rasseva, Victoria, Sahin, Mustafa, Sarbak, Aysegul, Savas, Emre, Schattke, Constanze, Schepartz, Lynne, Selcuk, Tayfun, Sevim-Erol, Ayla, Shamoon-Pour, Michel, Shephard, Henry M, Sideris, Athanasios, Simalcsik, Angela, Simonyan, Hakob, Sinika, Vitalij, Sirak, Kendra, Sirbu, Ghenadie, Slaus, Mario, Soficaru, Andrei, Sogut, Bilal, Soltysiak, Arkadiusz, Sonmez-Sozer, Cilem, Stathi, Maria, Steskal, Martin, Stewardson, Kristin, Stocker, Sharon, Suata-Alpaslan, Fadime, Suvorov, Alexander, Szecsenyi-Nagy, Anna, Szeniczey, Tamas, Telnov, Nikolai, Temov, Strahil, Todorova, Nadezhda, Tota, Ulsi, Touchais, Gilles, Triantaphyllou, Sevi, Turker, Atila, Ugarkovic, Marina, Valchev, Todor, Veljanovska, Fancia, Videvski, Zlatko, Virag, Christian, Wagner, Anna, Walsh, Samantha, Wlodarczak, Piotr, Workman, J Noah, Yardumian, Aram, Yarovoy, Evgenii, Yavuz, Alper Yener, Yilmaz, Hakan, Zalzala, Fatma, Zettl, Anna, Zhang, Zhao, Cavusoglu, Rafet, Rohland, Nadin, Pinhasi, Ron, and Reich, David
Abstract: Literary and archaeological sources have preserved a rich history of Southern Europe and West Asia since the Bronze Age that can be complemented by genetics. Mycenaean period elites in Greece did not differ from the general population and included both people with some steppe ancestry and others, like the Griffin Warrior, without it. Similarly, people in the central area of the Urartian Kingdom around Lake Van lacked the steppe ancestry characteristic of the kingdom’s northern provinces. Anatolia exhibited extraordinary continuity down to the Roman and Byzantine periods, with its people serving as the demographic core of much of the Roman Empire, including the city of Rome itself. During medieval times, migrations associated with Slavic and Turkic speakers profoundly affected the region.
Published: 2022

29. Large-scale migration into Britain during the Middle to Late Bronze Age

Author: Patterson, Nick, Isakov, Michael, Booth, Thomas, Büster, Lindsey, Fischer, Claire Elise, Olalde, Iñigo, Ringbauer, Harald, Akbari, Ali, Cheronet, Olivia, Bleasdale, Madeleine, Adamski, Nicole, Altena, Eveline, Bernardos, Rebecca, Brace, Selina, Broomandkhoshbacht, Nasreen, Callan, Kimberly, Candilio, Francesca, Culleton, Brendan, Curtis, Elizabeth, Demetz, Lea, Carlson, Kellie Sara Duffett, Fernandes, Daniel M., Foody, M. George B., Freilich, Suzanne, Goodchild, Helen, Kearns, Aisling, Lawson, Ann Marie, Lazaridis, Iosif, Mah, Matthew, Mallick, Swapan, Mandl, Kirsten, Micco, Adam, Michel, Megan, Morante, Guillermo Bravo, Oppenheimer, Jonas, Özdoğan, Kadir Toykan, Qiu, Lijun, Schattke, Constanze, Stewardson, Kristin, Workman, J. Noah, Zalzala, Fatma, Zhang, Zhao, Agustí, Bibiana, Allen, Tim, Almássy, Katalin, Amkreutz, Luc, Ash, Abigail, Baillif-Ducros, Christèle, Barclay, Alistair, Bartosiewicz, László, Baxter, Katherine, Bernert, Zsolt, Blažek, Jan, Bodružić, Mario, Boissinot, Philippe, Bonsall, Clive, Bradley, Pippa, Brittain, Marcus, Brookes, Alison, Brown, Fraser, Brown, Lisa, Brunning, Richard, Budd, Chelsea, Burmaz, Josip, Canet, Sylvain, Carnicero-Cáceres, Silvia, Čaušević-Bully, Morana, Chamberlain, Andrew, Chauvin, Sébastien, Clough, Sharon, Čondić, Natalija, Coppa, Alfredo, Craig, Oliver, Črešnar, Matija, Cummings, Vicki, Czifra, Szabolcs, Danielisová, Alžběta, Daniels, Robin, Davies, Alex, de Jersey, Philip, Deacon, Jody, Deminger, Csilla, Ditchfield, Peter W., Dizdar, Marko, Dobeš, Miroslav, Dobisíková, Miluše, Domboróczki, László, Drinkall, Gail, Đukić, Ana, Edwards, Ceiridwen J., Ernée, Michal, Evans, Christopher, Evans, Jane, Fernández-Götz, Manuel, Filipović, Slavica, Fitzpatrick, Andrew, Fokkens, Harry, Fowler, Chris, Fox, Allison, Gallina, Zsolt, Gamble, Michelle, González Morales, Manuel R., González-Rabanal, Borja, Green, Adrian, Gyenesei, Katalin, Habermehl, Diederick, Hajdu, Tamás, Hamilton, Derek, Harris, James, Hayden, Chris, Hendriks, Joep, Hernu, Bénédicte, Hey, Gill, Horňák, Milan, Ilon, Gábor, Istvánovits, Eszter, Jones, Andy M., Kavur, Martina Blečić, Kazek, Kevin, Kenyon, Robert A., Khreisheh, Amal, Kiss, Viktória, Kleijne, Jos, Knight, Mark, Kootker, Lisette M., Kovács, Péter F., Kozubová, Anita, Kulcsár, Gabriella, Kulcsár, Valéria, Le Pennec, Christophe, Legge, Michael, Leivers, Matt, Loe, Louise, López-Costas, Olalla, Lord, Tom, Los, Dženi, Lyall, James, Marín-Arroyo, Ana B., Mason, Philip, Matošević, Damir, Maxted, Andy, McIntyre, Lauren, McKinley, Jacqueline, McSweeney, Kathleen, Meijlink, Bernard, Mende, Balázs G., Menđušić, Marko, Metlička, Milan, Meyer, Sophie, Mihovilić, Kristina, Milasinovic, Lidija, Minnitt, Steve, Moore, Joanna, Morley, Geoff, Mullan, Graham, Musilová, Margaréta, Neil, Benjamin, Nicholls, Rebecca, Novak, Mario, Pala, Maria, Papworth, Martin, Paresys, Cécile, Patten, Ricky, Perkić, Domagoj, Pesti, Krisztina, Petit, Alba, Petriščáková, Katarína, Pichon, Coline, Pickard, Catriona, Pilling, Zoltán, Price, T. Douglas, Radović, Siniša, Redfern, Rebecca, Resutík, Branislav, Rhodes, Daniel T., Richards, Martin B., Roberts, Amy, Roefstra, Jean, Sankot, Pavel, Šefčáková, Alena, Sheridan, Alison, Skae, Sabine, Šmolíková, Miroslava, Somogyi, Krisztina, Somogyvári, Ágnes, Stephens, Mark, Szabó, Géza, Szécsényi-Nagy, Anna, Szeniczey, Tamás, Tabor, Jonathan, Tankó, Károly, Maria, Clenis Tavarez, Terry, Rachel, Teržan, Biba, Teschler-Nicola, Maria, Torres-Martínez, Jesús F., Trapp, Julien, Turle, Ross, Ujvári, Ferenc, van der Heiden, Menno, Veleminsky, Petr, Veselka, Barbara, Vytlačil, Zdeněk, Waddington, Clive, Ware, Paula, Wilkinson, Paul, Wilson, Linda, Wiseman, Rob, Young, Eilidh, Zaninović, Joško, Žitňan, Andrej, Lalueza-Fox, Carles, de Knijff, Peter, Barnes, Ian, Halkon, Peter, Thomas, Mark G., Kennett, Douglas J., Cunliffe, Barry, Lillie, Malcolm, Rohland, Nadin, Pinhasi, Ron, Armit, Ian, Reich, David, Patterson, Nick, Isakov, Michael, Booth, Thomas, Büster, Lindsey, Fischer, Claire Elise, Olalde, Iñigo, Ringbauer, Harald, Akbari, Ali, Cheronet, Olivia, Bleasdale, Madeleine, Adamski, Nicole, Altena, Eveline, Bernardos, Rebecca, Brace, Selina, Broomandkhoshbacht, Nasreen, Callan, Kimberly, Candilio, Francesca, Culleton, Brendan, Curtis, Elizabeth, Demetz, Lea, Carlson, Kellie Sara Duffett, Fernandes, Daniel M., Foody, M. George B., Freilich, Suzanne, Goodchild, Helen, Kearns, Aisling, Lawson, Ann Marie, Lazaridis, Iosif, Mah, Matthew, Mallick, Swapan, Mandl, Kirsten, Micco, Adam, Michel, Megan, Morante, Guillermo Bravo, Oppenheimer, Jonas, Özdoğan, Kadir Toykan, Qiu, Lijun, Schattke, Constanze, Stewardson, Kristin, Workman, J. Noah, Zalzala, Fatma, Zhang, Zhao, Agustí, Bibiana, Allen, Tim, Almássy, Katalin, Amkreutz, Luc, Ash, Abigail, Baillif-Ducros, Christèle, Barclay, Alistair, Bartosiewicz, László, Baxter, Katherine, Bernert, Zsolt, Blažek, Jan, Bodružić, Mario, Boissinot, Philippe, Bonsall, Clive, Bradley, Pippa, Brittain, Marcus, Brookes, Alison, Brown, Fraser, Brown, Lisa, Brunning, Richard, Budd, Chelsea, Burmaz, Josip, Canet, Sylvain, Carnicero-Cáceres, Silvia, Čaušević-Bully, Morana, Chamberlain, Andrew, Chauvin, Sébastien, Clough, Sharon, Čondić, Natalija, Coppa, Alfredo, Craig, Oliver, Črešnar, Matija, Cummings, Vicki, Czifra, Szabolcs, Danielisová, Alžběta, Daniels, Robin, Davies, Alex, de Jersey, Philip, Deacon, Jody, Deminger, Csilla, Ditchfield, Peter W., Dizdar, Marko, Dobeš, Miroslav, Dobisíková, Miluše, Domboróczki, László, Drinkall, Gail, Đukić, Ana, Edwards, Ceiridwen J., Ernée, Michal, Evans, Christopher, Evans, Jane, Fernández-Götz, Manuel, Filipović, Slavica, Fitzpatrick, Andrew, Fokkens, Harry, Fowler, Chris, Fox, Allison, Gallina, Zsolt, Gamble, Michelle, González Morales, Manuel R., González-Rabanal, Borja, Green, Adrian, Gyenesei, Katalin, Habermehl, Diederick, Hajdu, Tamás, Hamilton, Derek, Harris, James, Hayden, Chris, Hendriks, Joep, Hernu, Bénédicte, Hey, Gill, Horňák, Milan, Ilon, Gábor, Istvánovits, Eszter, Jones, Andy M., Kavur, Martina Blečić, Kazek, Kevin, Kenyon, Robert A., Khreisheh, Amal, Kiss, Viktória, Kleijne, Jos, Knight, Mark, Kootker, Lisette M., Kovács, Péter F., Kozubová, Anita, Kulcsár, Gabriella, Kulcsár, Valéria, Le Pennec, Christophe, Legge, Michael, Leivers, Matt, Loe, Louise, López-Costas, Olalla, Lord, Tom, Los, Dženi, Lyall, James, Marín-Arroyo, Ana B., Mason, Philip, Matošević, Damir, Maxted, Andy, McIntyre, Lauren, McKinley, Jacqueline, McSweeney, Kathleen, Meijlink, Bernard, Mende, Balázs G., Menđušić, Marko, Metlička, Milan, Meyer, Sophie, Mihovilić, Kristina, Milasinovic, Lidija, Minnitt, Steve, Moore, Joanna, Morley, Geoff, Mullan, Graham, Musilová, Margaréta, Neil, Benjamin, Nicholls, Rebecca, Novak, Mario, Pala, Maria, Papworth, Martin, Paresys, Cécile, Patten, Ricky, Perkić, Domagoj, Pesti, Krisztina, Petit, Alba, Petriščáková, Katarína, Pichon, Coline, Pickard, Catriona, Pilling, Zoltán, Price, T. Douglas, Radović, Siniša, Redfern, Rebecca, Resutík, Branislav, Rhodes, Daniel T., Richards, Martin B., Roberts, Amy, Roefstra, Jean, Sankot, Pavel, Šefčáková, Alena, Sheridan, Alison, Skae, Sabine, Šmolíková, Miroslava, Somogyi, Krisztina, Somogyvári, Ágnes, Stephens, Mark, Szabó, Géza, Szécsényi-Nagy, Anna, Szeniczey, Tamás, Tabor, Jonathan, Tankó, Károly, Maria, Clenis Tavarez, Terry, Rachel, Teržan, Biba, Teschler-Nicola, Maria, Torres-Martínez, Jesús F., Trapp, Julien, Turle, Ross, Ujvári, Ferenc, van der Heiden, Menno, Veleminsky, Petr, Veselka, Barbara, Vytlačil, Zdeněk, Waddington, Clive, Ware, Paula, Wilkinson, Paul, Wilson, Linda, Wiseman, Rob, Young, Eilidh, Zaninović, Joško, Žitňan, Andrej, Lalueza-Fox, Carles, de Knijff, Peter, Barnes, Ian, Halkon, Peter, Thomas, Mark G., Kennett, Douglas J., Cunliffe, Barry, Lillie, Malcolm, Rohland, Nadin, Pinhasi, Ron, Armit, Ian, and Reich, David
Abstract: Present-day people from England and Wales harbour more ancestry derived from Early European Farmers (EEF) than people of the Early Bronze Age1. To understand this, we generated genome-wide data from 793 individuals, increasing data from the Middle to Late Bronze and Iron Age in Britain by 12-fold, and Western and Central Europe by 3.5-fold. Between 1000 and 875 bc, EEF ancestry increased in southern Britain (England and Wales) but not northern Britain (Scotland) due to incorporation of migrants who arrived at this time and over previous centuries, and who were genetically most similar to ancient individuals from France. These migrants contributed about half the ancestry of Iron Age people of England and Wales, thereby creating a plausible vector for the spread of early Celtic languages into Britain. These patterns are part of a broader trend of EEF ancestry becoming more similar across central and western Europe in the Middle to Late Bronze Age, coincident with archaeological evidence of intensified cultural exchange2–6. There was comparatively less gene flow from continental Europe during the Iron Age, and Britain’s independent genetic trajectory is also reflected in the rise of the allele conferring lactase persistence to ~50% by this time compared to ~7% in central Europe where it rose rapidly in frequency only a millennium later. This suggests that dairy products were used in qualitatively different ways in Britain and in central Europe over this period.
Published: 2022
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30. Single Carrier Frequency Domain Detectors for Internet of Underwater Things

Author: Aljanabi, Amer, Alluhaibi, Osama, Ahmed, Qasim Z., Khan, Fahd A., Waqas-Bin-Abbas, Lazaridis, Pavlos I., Aljanabi, Amer, Alluhaibi, Osama, Ahmed, Qasim Z., Khan, Fahd A., Waqas-Bin-Abbas, and Lazaridis, Pavlos I.
Abstract: This paper proposes low complexity detection for internet of underwater things (IoUT)s communication. The signal is transmitted from the source to the destination using several sensors. To simplify the computational operations at the transmitter and the sensory nodes, a single carrier frequency domain equalizer (SC-FDE) is proposed and amplify-and-forward (AF) protocols are employed. Fast Fourier transform (FFT) and use of cyclic prefix (CP) are also proposed to simplify these algorithms when compared to time-domain equalization. As precise channel data is difficult to capture in underwater communications, the adaptive implementation of FDE is proposed as a solution that can be employed when the channel experiences a fast doppler shift. The two adaptive detectors are based on the least mean-square (LMS) and recursive least square (RLS) principles. Numerical simulations show that the performance of the bit error rate (BER) performance of the proposed detectors is close to that of the ideal minimum mean square error (MMSE).
Published: 2022

31. Large-scale migration into Britain during the Middle to Late Bronze Age

Author: European Research Council, Croatian Science Foundation, Ministry of Culture (Czech Republic), Academy of Sciences of the Czech Republic, Leverhulme Trust, Culture Vannin, Hungarian Academy of Sciences, National Research, Development and Innovation Office (Hungary), Ministerio de Ciencia e Innovación (España), National Institutes of Health (US), John Templeton Foundation, Paul G. Allen Family Foundation, Howard Hughes Medical Institute, Patterson, Nick, Isakov, Michael, Booth, Thomas, Büster, Lindsey, Fischer, Claire-Elise, Olalde, Iñigo, Ringbauer, Harald, Akbari, Ali, Cheronet, Olivia, Bleasdale, Madeleine, Adamski, Nicole, Šefčáková, Alena, Curtis, Elizabeth, Sheridan, Alison, Glenis Tavarez Maria, Terry, Rachel, Teržan, Biba, Teschler-Nicola, Maria, Brunning, Richard, Torres-Martínez, Jesús F., Lawson, Ann Marie, Fowler, Chris, Trapp, Julien, Turle, Ross, Ujvári, Ferenc, van der Heiden, Menno, González Morales, Manuel R., Carlson, Kellie Sara Duffett, Veleminsky, Petr, Veselka, Barbara, Vytlačil, Zdeněk, Budd, Chelsea, Fox, Allison, Carnicero-Cáceres, Silvia, Waddington, Clive, Ware, Paula, Wilkinson, Paul, Wilson, Linda, Wiseman, Rob, Young, Eilidh, González-Rabanal, Borja, Zaninović, Joško, Edwards, Ceiridwen J, Gallina, Zsolt, Žitňan, Andrej, McSweeney, Kathleen, Burmaz, Josip, Lalueza-Fox, Carles, de Knijff, Peter, Barnes, Ian, Halkon, Peter, Thomas, Mark G, Kennett, Douglas J., Cunliffe, Barry, Hernu, Bénédicte, Green, Adrian, Lillie, Malcolm, Lazaridis, Iosif, Rohland, Nadin, Canet, Sylvain, Fernandes, Daniel M, Mah, Matthew, Mallick, Swapan, Mandl, Kirsten, Micco, Adam, Hey, Gill, Michel, Megan, Morante, Guillermo Bravo, Oppenheimer, Jonas, Özdoğan, Kadir Toykan, Habermehl, Diederick, Meijlink, Bernard, Harris, James, Qiu, Lijun, Schattke, Constanze, Stewardson, Kristin, Horňák, Milan, Workman, J Noah, Zalzala, Fatma, Zhang, Zhao, Agustí, Bibiana, Allen, Tim, Almássy, Katalin, Mende, Balazs G., Amkreutz, Luc, Skae, Sabine, Hajdu, Tamás, Ilon, Gábor, Ash, Abigail, Baillif-Ducros, Christèle, Barclay, Alistair, Bartosiewicz, László, Baxter, Katherine, Bernert, Zsolt, Blažek, Jan, Menđušić, Marko, Bodružić, Mario, Boissinot, Philippe, Stephens, Mark, Čaušević-Bully, Morana, Bonsall, Clive, Hamilton, Derek, Bradley, Pippa, Chamberlain, Andrew, Chauvin, Sébastien, Clough, Sharon, Čondić, Natalija, Metlička, Milan, Coppa, Alfredo, Istvánovits, Eszter, Craig, Oliver, Črešnar, Matija, Cummings, Vicki, Czifra, Szabolcs, Šmolíková, Miroslava, Hayden, Chris, Danielisová, Alžběta, Daniels, Robin, Davies, Alex, Meyer, Sophie, Milasinovic, Lidija, de Jersey, Philip, Deacon, Jody, Deminger, Csilla, Ditchfield, Peter W, Dizdar, Marko, Dobeš, Miroslav, Somogyi, Krisztina, Dobisíková, Miluše, Altena, Eveline, Domboróczki, László, Pinhasi, Ron, Mihovilić, Kristina, Drinkall, Gail, Đukić, Ana, Ernée, Michal, Evans, Christopher, Evans, Jane, Fernández-Götz, Manuel, Filipović, Slavica, Somogyvári, Ágnes, Fitzpatrick, Andrew, Jones, Andy M, Fokkens, Harry, Callan, Kimberly, Hendriks, Joep, Kavur, Martina Blečić, Kazek, Kevin, Kenyon, Robert A, Bernardos, Rebecca, Khreisheh, Amal, Kiss, Viktória, Kleijne, Jos, Knight, Mark, Szabó, Géza, Armit, Ian, Tabor, Jonathan, Kootker, Lisette M, Kovács, Péter F, Kozubová, Anita, Kulcsár, Gabriella, Kulcsár, Valéria, Le Pennec, Christophe, Brace, Selina, Legge, Michael, Leivers, Matt, Reich, David, Loe, Louise, Brittain, Marcus, Szécsényi-Nagy, Anna, López-Costas, Olalla, Lord, Tom, Los, Dženi, Lyall, James, Marín-Arroyo, Ana B., Mason, Philip, Matošević, Damir, Foody, M George B, Broomandkhoshbacht, Nasreen, Maxted, Andy, Minnitt, Steve, McIntyre, Lauren, Szeniczey, Tamás, McKinley, Jacqueline, Moore, Joanna, Morley, Geoff, Mullan, Graham, Musilová, Margaréta, Freilich, Suzanne, Neil, Benjamin, Nicholls, Rebecca, Novak, Mario, Pala, Maria, Candilio, Francesca, Brookes, Alison, Demetz, Lea, Papworth, Martin, Paresys, Cécile, Patten, Ricky, Goodchild, Helen, Perkić, Domagoj, Pesti, Krisztina, Petit, Alba, Petriščáková, Katarína, Pichon, Coline, Pickard, Catriona, Brown, Fraser, Pilling, Zoltán, Gamble, Michelle, Culleton, Brendan, Kearns, Aisling, Price, T. Douglas, Radović, Siniša, Redfern, Rebecca, Resutík, Branislav, Rhodes, Daniel T, Richards, Martin B, Roberts, Amy, Brown, Lisa, Roefstra, Jean, Sankot, Pavel, Gyenesei, Katalin, Tankó, Károly, European Research Council, Croatian Science Foundation, Ministry of Culture (Czech Republic), Academy of Sciences of the Czech Republic, Leverhulme Trust, Culture Vannin, Hungarian Academy of Sciences, National Research, Development and Innovation Office (Hungary), Ministerio de Ciencia e Innovación (España), National Institutes of Health (US), John Templeton Foundation, Paul G. Allen Family Foundation, Howard Hughes Medical Institute, Patterson, Nick, Isakov, Michael, Booth, Thomas, Büster, Lindsey, Fischer, Claire-Elise, Olalde, Iñigo, Ringbauer, Harald, Akbari, Ali, Cheronet, Olivia, Bleasdale, Madeleine, Adamski, Nicole, Šefčáková, Alena, Curtis, Elizabeth, Sheridan, Alison, Glenis Tavarez Maria, Terry, Rachel, Teržan, Biba, Teschler-Nicola, Maria, Brunning, Richard, Torres-Martínez, Jesús F., Lawson, Ann Marie, Fowler, Chris, Trapp, Julien, Turle, Ross, Ujvári, Ferenc, van der Heiden, Menno, González Morales, Manuel R., Carlson, Kellie Sara Duffett, Veleminsky, Petr, Veselka, Barbara, Vytlačil, Zdeněk, Budd, Chelsea, Fox, Allison, Carnicero-Cáceres, Silvia, Waddington, Clive, Ware, Paula, Wilkinson, Paul, Wilson, Linda, Wiseman, Rob, Young, Eilidh, González-Rabanal, Borja, Zaninović, Joško, Edwards, Ceiridwen J, Gallina, Zsolt, Žitňan, Andrej, McSweeney, Kathleen, Burmaz, Josip, Lalueza-Fox, Carles, de Knijff, Peter, Barnes, Ian, Halkon, Peter, Thomas, Mark G, Kennett, Douglas J., Cunliffe, Barry, Hernu, Bénédicte, Green, Adrian, Lillie, Malcolm, Lazaridis, Iosif, Rohland, Nadin, Canet, Sylvain, Fernandes, Daniel M, Mah, Matthew, Mallick, Swapan, Mandl, Kirsten, Micco, Adam, Hey, Gill, Michel, Megan, Morante, Guillermo Bravo, Oppenheimer, Jonas, Özdoğan, Kadir Toykan, Habermehl, Diederick, Meijlink, Bernard, Harris, James, Qiu, Lijun, Schattke, Constanze, Stewardson, Kristin, Horňák, Milan, Workman, J Noah, Zalzala, Fatma, Zhang, Zhao, Agustí, Bibiana, Allen, Tim, Almássy, Katalin, Mende, Balazs G., Amkreutz, Luc, Skae, Sabine, Hajdu, Tamás, Ilon, Gábor, Ash, Abigail, Baillif-Ducros, Christèle, Barclay, Alistair, Bartosiewicz, László, Baxter, Katherine, Bernert, Zsolt, Blažek, Jan, Menđušić, Marko, Bodružić, Mario, Boissinot, Philippe, Stephens, Mark, Čaušević-Bully, Morana, Bonsall, Clive, Hamilton, Derek, Bradley, Pippa, Chamberlain, Andrew, Chauvin, Sébastien, Clough, Sharon, Čondić, Natalija, Metlička, Milan, Coppa, Alfredo, Istvánovits, Eszter, Craig, Oliver, Črešnar, Matija, Cummings, Vicki, Czifra, Szabolcs, Šmolíková, Miroslava, Hayden, Chris, Danielisová, Alžběta, Daniels, Robin, Davies, Alex, Meyer, Sophie, Milasinovic, Lidija, de Jersey, Philip, Deacon, Jody, Deminger, Csilla, Ditchfield, Peter W, Dizdar, Marko, Dobeš, Miroslav, Somogyi, Krisztina, Dobisíková, Miluše, Altena, Eveline, Domboróczki, László, Pinhasi, Ron, Mihovilić, Kristina, Drinkall, Gail, Đukić, Ana, Ernée, Michal, Evans, Christopher, Evans, Jane, Fernández-Götz, Manuel, Filipović, Slavica, Somogyvári, Ágnes, Fitzpatrick, Andrew, Jones, Andy M, Fokkens, Harry, Callan, Kimberly, Hendriks, Joep, Kavur, Martina Blečić, Kazek, Kevin, Kenyon, Robert A, Bernardos, Rebecca, Khreisheh, Amal, Kiss, Viktória, Kleijne, Jos, Knight, Mark, Szabó, Géza, Armit, Ian, Tabor, Jonathan, Kootker, Lisette M, Kovács, Péter F, Kozubová, Anita, Kulcsár, Gabriella, Kulcsár, Valéria, Le Pennec, Christophe, Brace, Selina, Legge, Michael, Leivers, Matt, Reich, David, Loe, Louise, Brittain, Marcus, Szécsényi-Nagy, Anna, López-Costas, Olalla, Lord, Tom, Los, Dženi, Lyall, James, Marín-Arroyo, Ana B., Mason, Philip, Matošević, Damir, Foody, M George B, Broomandkhoshbacht, Nasreen, Maxted, Andy, Minnitt, Steve, McIntyre, Lauren, Szeniczey, Tamás, McKinley, Jacqueline, Moore, Joanna, Morley, Geoff, Mullan, Graham, Musilová, Margaréta, Freilich, Suzanne, Neil, Benjamin, Nicholls, Rebecca, Novak, Mario, Pala, Maria, Candilio, Francesca, Brookes, Alison, Demetz, Lea, Papworth, Martin, Paresys, Cécile, Patten, Ricky, Goodchild, Helen, Perkić, Domagoj, Pesti, Krisztina, Petit, Alba, Petriščáková, Katarína, Pichon, Coline, Pickard, Catriona, Brown, Fraser, Pilling, Zoltán, Gamble, Michelle, Culleton, Brendan, Kearns, Aisling, Price, T. Douglas, Radović, Siniša, Redfern, Rebecca, Resutík, Branislav, Rhodes, Daniel T, Richards, Martin B, Roberts, Amy, Brown, Lisa, Roefstra, Jean, Sankot, Pavel, Gyenesei, Katalin, and Tankó, Károly
Abstract: Present-day people from England and Wales have more ancestry derived from early European farmers (EEF) than did people of the Early Bronze Age1. To understand this, here we generated genome-wide data from 793 individuals, increasing data from the Middle to the Late Bronze Age and Iron Age in Britain by 12-fold, and western and central Europe by 3.5-fold. Between 1000 and 875 BC, EEF ancestry increased in southern Britain (England and Wales) but not northern Britain (Scotland) due to incorporation of migrants who arrived at this time and over previous centuries, and who were genetically most similar to ancient individuals from France. These migrants contributed about half the ancestry of people of England and Wales from the Iron Age, thereby creating a plausible vector for the spread of early Celtic languages into Britain. These patterns are part of a broader trend of EEF ancestry becoming more similar across central and western Europe in the Middle to the Late Bronze Age, coincident with archaeological evidence of intensified cultural exchange2-6. There was comparatively less gene flow from continental Europe during the Iron Age, and the independent genetic trajectory in Britain is also reflected in the rise of the allele conferring lactase persistence to approximately 50% by this time compared to approximately 7% in central Europe where it rose rapidly in frequency only a millennium later. This suggests that dairy products were used in qualitatively different ways in Britain and in central Europe over this period.
Published: 2022

32. Ancient DNA from Mesopotamia suggests distinct Pre-Pottery and Pottery Neolithic migrations into Anatolia

Author: Lazaridis, Iosif, Alpaslan-Roodenberg, Songül, Acar, Ayşe, Açıkkol, Ayşen, Agelarakis, Anagnostis, Aghikyan, Levon, Akyüz, Uğur, Andreeva, Desislava, Andrijašević, Gojko, Antonović, Dragana, Armit, Ian, Atmaca, Alper, Avetisyan, Pavel, Aytek, Ahmet İhsan, Bacvarov, Krum, Badalyan, Ruben, Bakardzhiev, Stefan, Balen, Jacqueline, Bejko, Lorenc, Bernardos, Rebecca, Bertsatos, Andreas, Biber, Hanifi, Bilir, Ahmet, Bodružić, Mario, Bonogofsky, Michelle, Bonsall, Clive, Borić, Dušan, Borovinić, Nikola, Bravo Morante, Guillermo, Buttinger, Katharina, Callan, Kim, Candilio, Francesca, Carić, Mario, Cheronet, Olivia, Chohadzhiev, Stefan, Chovalopoulou, Maria-Eleni, Chryssoulaki, Stella, Ciobanu, Ion, Čondić, Natalija, Constantinescu, Mihai, Cristiani, Emanuela, Culleton, Brendan J., Curtis, Elizabeth, Davis, Jack, Demcenco, Tatiana I., Dergachev, Valentin, Derin, Zafer, Deskaj, Sylvia, Devejyan, Seda, Djordjević, Vojislav, Duffett Carlson, Kellie Sara, Eccles, Laurie R., Elenski, Nedko, Engin, Atilla, Erdoğan, Nihat, Erir-Pazarcı, Sabiha, Fernandes, Daniel M., Ferry, Matthew, Freilich, Suzanne, Frînculeasa, Alin, Galaty, Michael L., Gamarra, Beatriz, Gasparyan, Boris, Gaydarska, Bisserka, Genç, Elif, Gültekin, Timur, Gündüz, Serkan, Hajdu, Tamás, Heyd, Volker, Hobosyan, Suren, Hovhannisyan, Nelli, Iliev, Iliya, Iliev, Lora, Iliev, Stanislav, İvgin, İlkay, Janković, Ivor, Jovanova, Lence, Karkanas, Panagiotis, Kavaz-Kındığılı, Berna, Kaya, Esra Hilal, Keating, Denise, Kennett, Douglas J., Deniz Kesici, Seda, Khudaverdyan, Anahit, Kiss, Krisztián, Kılıç, Sinan, Klostermann, Paul, Kostak Boca Negra Valdes, Sinem, Kovačević, Saša, Krenz-Niedbała, Marta, Krznarić Škrivanko, Maja, Kurti, Rovena, Kuzman, Pasko, Lawson, Ann Marie, Lazar, Catalin, Leshtakov, Krassimir, Levy, Thomas E., Liritzis, Ioannis, Lorentz, Kirsi O., Łukasik, Sylwia, Mah, Matthew, Mallick, Swapan, Mandl, Kirsten, Martirosyan-Olshansky, Kristine, Matthews, Roger, Matthews, Wendy, McSweeney, Kathleen, Melikyan, Varduhi, Micco, Adam, Michel, Megan, Milašinović, Lidija, Mittnik, Alissa, Monge, Janet M., Nekhrizov, Georgi, Nicholls, Rebecca, Nikitin, Alexey G., Nikolov, Vassil, Novak, Mario, Olalde, Iñigo, Oppenheimer, Jonas, Osterholtz, Anna, Özdemir, Celal, Özdoğan, Kadir Toykan, Öztürk, Nurettin, Papadimitriou, Nikos, Papakonstantinou, Niki, Papathanasiou, Anastasia, Paraman, Lujana, Paskary, Evgeny G., Patterson, Nick, Petrakiev, Ilian, Petrosyan, Levon, Petrova, Vanya, Philippa-Touchais, Anna, Piliposyan, Ashot, Pocuca Kuzman, Nada, Potrebica, Hrvoje, Preda-Bălănică, Bianca, Premužić, Zrinka, Price, T. Douglas, Qiu, Lijun, Radović, Siniša, Raeuf Aziz, Kamal, Rajić Šikanjić, Petra, Rasheed Raheem, Kamal, Razumov, Sergei, Richardson, Amy, Roodenberg, Jacob, Ruka, Rudenc, Russeva, Victoria, Şahin, Mustafa, Şarbak, Ayşegül, Savaş, Emre, Schattke, Constanze, Schepartz, Lynne, Selçuk, Tayfun, Sevim-Erol, Ayla, Shamoon-Pour, Michel, Shephard, Henry M., Sideris, Athanasios, Simalcsik, Angela, Simonyan, Hakob, Sinika, Vitalij, Sirak, Kendra, Sirbu, Ghenadie, Šlaus, Mario, Soficaru, Andrei, Söğüt, Bilal, Sołtysiak, Arkadiusz, Sönmez-Sözer, Çilem, Stathi, Maria, Steskal, Martin, Stewardson, Kristin, Stocker, Sharon, Suata-Alpaslan, Fadime, Suvorov, Alexander, Szécsényi-Nagy, Anna, Szeniczey, Tamás, Telnov, Nikolai, Temov, Strahil, Todorova, Nadezhda, Tota, Ulsi, Touchais, Gilles, Triantaphyllou, Sevi, Türker, Atila, Ugarković, Marina, Valchev, Todor, Veljanovska, Fanica, Videvski, Zlatko, Virag, Cristian, Wagner, Anna, Walsh, Samantha, Włodarczak, Piotr, Workman, J. Noah, Yardumian, Aram, Yarovoy, Evgenii, Yavuz, Alper Yener, Yılmaz, Hakan, Zalzala, Fatma, Zettl, Anna, Zhang, Zhao, Çavuşoğlu, Rafet, Rohland, Nadin, Pinhasi, Ron, Reich, David, Lazaridis, Iosif, Alpaslan-Roodenberg, Songül, Acar, Ayşe, Açıkkol, Ayşen, Agelarakis, Anagnostis, Aghikyan, Levon, Akyüz, Uğur, Andreeva, Desislava, Andrijašević, Gojko, Antonović, Dragana, Armit, Ian, Atmaca, Alper, Avetisyan, Pavel, Aytek, Ahmet İhsan, Bacvarov, Krum, Badalyan, Ruben, Bakardzhiev, Stefan, Balen, Jacqueline, Bejko, Lorenc, Bernardos, Rebecca, Bertsatos, Andreas, Biber, Hanifi, Bilir, Ahmet, Bodružić, Mario, Bonogofsky, Michelle, Bonsall, Clive, Borić, Dušan, Borovinić, Nikola, Bravo Morante, Guillermo, Buttinger, Katharina, Callan, Kim, Candilio, Francesca, Carić, Mario, Cheronet, Olivia, Chohadzhiev, Stefan, Chovalopoulou, Maria-Eleni, Chryssoulaki, Stella, Ciobanu, Ion, Čondić, Natalija, Constantinescu, Mihai, Cristiani, Emanuela, Culleton, Brendan J., Curtis, Elizabeth, Davis, Jack, Demcenco, Tatiana I., Dergachev, Valentin, Derin, Zafer, Deskaj, Sylvia, Devejyan, Seda, Djordjević, Vojislav, Duffett Carlson, Kellie Sara, Eccles, Laurie R., Elenski, Nedko, Engin, Atilla, Erdoğan, Nihat, Erir-Pazarcı, Sabiha, Fernandes, Daniel M., Ferry, Matthew, Freilich, Suzanne, Frînculeasa, Alin, Galaty, Michael L., Gamarra, Beatriz, Gasparyan, Boris, Gaydarska, Bisserka, Genç, Elif, Gültekin, Timur, Gündüz, Serkan, Hajdu, Tamás, Heyd, Volker, Hobosyan, Suren, Hovhannisyan, Nelli, Iliev, Iliya, Iliev, Lora, Iliev, Stanislav, İvgin, İlkay, Janković, Ivor, Jovanova, Lence, Karkanas, Panagiotis, Kavaz-Kındığılı, Berna, Kaya, Esra Hilal, Keating, Denise, Kennett, Douglas J., Deniz Kesici, Seda, Khudaverdyan, Anahit, Kiss, Krisztián, Kılıç, Sinan, Klostermann, Paul, Kostak Boca Negra Valdes, Sinem, Kovačević, Saša, Krenz-Niedbała, Marta, Krznarić Škrivanko, Maja, Kurti, Rovena, Kuzman, Pasko, Lawson, Ann Marie, Lazar, Catalin, Leshtakov, Krassimir, Levy, Thomas E., Liritzis, Ioannis, Lorentz, Kirsi O., Łukasik, Sylwia, Mah, Matthew, Mallick, Swapan, Mandl, Kirsten, Martirosyan-Olshansky, Kristine, Matthews, Roger, Matthews, Wendy, McSweeney, Kathleen, Melikyan, Varduhi, Micco, Adam, Michel, Megan, Milašinović, Lidija, Mittnik, Alissa, Monge, Janet M., Nekhrizov, Georgi, Nicholls, Rebecca, Nikitin, Alexey G., Nikolov, Vassil, Novak, Mario, Olalde, Iñigo, Oppenheimer, Jonas, Osterholtz, Anna, Özdemir, Celal, Özdoğan, Kadir Toykan, Öztürk, Nurettin, Papadimitriou, Nikos, Papakonstantinou, Niki, Papathanasiou, Anastasia, Paraman, Lujana, Paskary, Evgeny G., Patterson, Nick, Petrakiev, Ilian, Petrosyan, Levon, Petrova, Vanya, Philippa-Touchais, Anna, Piliposyan, Ashot, Pocuca Kuzman, Nada, Potrebica, Hrvoje, Preda-Bălănică, Bianca, Premužić, Zrinka, Price, T. Douglas, Qiu, Lijun, Radović, Siniša, Raeuf Aziz, Kamal, Rajić Šikanjić, Petra, Rasheed Raheem, Kamal, Razumov, Sergei, Richardson, Amy, Roodenberg, Jacob, Ruka, Rudenc, Russeva, Victoria, Şahin, Mustafa, Şarbak, Ayşegül, Savaş, Emre, Schattke, Constanze, Schepartz, Lynne, Selçuk, Tayfun, Sevim-Erol, Ayla, Shamoon-Pour, Michel, Shephard, Henry M., Sideris, Athanasios, Simalcsik, Angela, Simonyan, Hakob, Sinika, Vitalij, Sirak, Kendra, Sirbu, Ghenadie, Šlaus, Mario, Soficaru, Andrei, Söğüt, Bilal, Sołtysiak, Arkadiusz, Sönmez-Sözer, Çilem, Stathi, Maria, Steskal, Martin, Stewardson, Kristin, Stocker, Sharon, Suata-Alpaslan, Fadime, Suvorov, Alexander, Szécsényi-Nagy, Anna, Szeniczey, Tamás, Telnov, Nikolai, Temov, Strahil, Todorova, Nadezhda, Tota, Ulsi, Touchais, Gilles, Triantaphyllou, Sevi, Türker, Atila, Ugarković, Marina, Valchev, Todor, Veljanovska, Fanica, Videvski, Zlatko, Virag, Cristian, Wagner, Anna, Walsh, Samantha, Włodarczak, Piotr, Workman, J. Noah, Yardumian, Aram, Yarovoy, Evgenii, Yavuz, Alper Yener, Yılmaz, Hakan, Zalzala, Fatma, Zettl, Anna, Zhang, Zhao, Çavuşoğlu, Rafet, Rohland, Nadin, Pinhasi, Ron, and Reich, David
Abstract: We present the first ancient DNA data from the Pre-Pottery Neolithic of Mesopotamia (Southeastern Turkey and Northern Iraq), Cyprus, and the Northwestern Zagros, along with the first data from Neolithic Armenia. We show that these and neighboring populations were formed through admixture of pre-Neolithic sources related to Anatolian, Caucasus, and Levantine hunter-gatherers, forming a Neolithic continuum of ancestry mirroring the geography of West Asia. By analyzing Pre-Pottery and Pottery Neolithic populations of Anatolia, we show that the former were derived from admixture between Mesopotamian-related and local Epipaleolithic-related sources, but the latter experienced additional Levantine-related gene flow, thus documenting at least two pulses of migration from the Fertile Crescent heartland to the early farmers of Anatolia.
Published: 2022

33. A genetic probe into the ancient and medieval history of Southern Europe and West Asia

Author: Lazaridis, Iosif, Alpaslan-Roodenberg, Songul, Acar, Ayse, Acikkol, Aysen, Agelarakis, Anagnostis, Aghikyan, Levon, Akyuz, Ugur, Andreeva, Desislava, Andrijasevic, Gojko, Anatonovic, Dragana, Armit, Ian, Atmaca, Alper, Avetisyan, Alper, Avetisyan, Pavel, Aytek, Ahmet Ihsan, Bacvarov, Krum, Badalyan, Ruben, Bakardzhiev, Stefan, Balen, Jacqueline, Bejko, Lorenc, Bernardos, Rebecca, Bertsatos, Andreas, Biber, Hanifi, Bilir, Ahmet, Brodruzic, Mario, Bonogofsky, Michelle, Bonsall, Clive, Boric, Dusan, Borovinic, Nikola, Morante, Guillermo Bravo, Buttinger, Katharina, Callan, Kim, Candilio, Francesca, Caric, Mario, Cheronet, Olivia, Chohadzhiev, Stefan, Chovalopoulou, Maria-Eleni, Chryssoulaki, Stella, Ciobanu, Ion, Condic, Natalija, Constantienescu, Mihai, Cristiani, Emanuela, Culleton, Brendan J, Curtis, Elizabeth, Davis, Jack, Davtyan, Ruben, Demcenco, Tatiana I, Dergachev, Valentin, Derin, Zafer, Deskaj, Sylvia, Devejyan, Seda, Djordjevic, Vojislav, Duffett Carlson, Kellie Sara, Eccles, Laurie R, Elenski, Nedko, Engin, Atilla, Erdogan, Nihat, Erir-Pazarci, Sabiha, Fernandes, Daniel M, Ferry, Matthew, Freilich, Suzanne, Frinculeasa, Alin, Galaty, Michael L, Gamarra, Beatriz, Gasparyan, Boris, Gaydarska, Bisserka, Genc, Elif, Gultekin, Timur, Gunduz, Serkan, Hajdu, Tamas, Heyd, Volker, Hobosyan, Suren, Hovhannisyan, Nelli, Iliev, Ilya, Iliev, Stanislav, Ivgin, Ilkay, Jankovic, Ivor, Jovanova, Lence, Karkanas, Panagiotis, Kavaz-Kindigili, Berna, Kaya, Esra Hilal, Keating, Denise, Kennett, Douglas J, Kesici, Seda Deniz, Khudaverdyan, Anahit, Kiss, Krisztian, Kilic, Sinan, Klostermann, Paul, Negra Valdes, Sniem Kostak Boca, Kovacevic, Sasa, Krenz-Niedbala, Marta, Skrivanko, Maja Krznaric, Kurti, Rovena, Kuzman, Pasko, Lawson, Ann Marie, Lazar, Catalin, Leshtakov, Krassimir, Levy, Thomas E, Liritzis, Ioannis, Lorentz, Kirsi O, Lukasik, Sylwia, Mah, Matthew, Mallick, Swapan, Mandl, Kirsten, Martirosyan-Olshansky, Kristine, Matthews, Roger, Matthews, Wendy, McSweeney, Kathleen, Melikyan, Varduhi, Micco, Adam, Michel, Megan, Milasinovic, Lidija, Mittnik, Alissa, Monge, Janet M, Nekhrizov, Georgi, Nicholls, Rebecca, Nikitin, Alexey G, Nikolov, Vassil, Novak, Mario, Olalde, Inigo, Oppenheimer, Jonas, Osterholtz, Anna, Ozdemir, Celal, Ozdogan, Kadir Toykan, Ozturk, Nurettin, Papadimitriou, Nikos, Papakonstantinou, Niki, Papathanasiou, Anastasia, Paraman, Lujana, Paskary, Evgeny G, Patterson, Nick, Petrakiev, Ilian, Petrosyan, Levon, Petrova, Vanya, Phillippa-Touchais, Anna, Piliposyan, Ashot, Pocuca Kuzman, Nada, Potrebica, Hrvoje, Preda-Balancia, Bianca, Premuzic, Zrinka, Price, T Douglas, Qiu, Lijun, Radovic, Sinisa, Raeuf Aziz, Kamal, Rajic Sikanjic, Petra, Rasheed Raheem, Kamal, Razumov, Sergei, Richardson, Amy, Roodenberg, Jacob, Ruka, Rudenc, Rasseva, Victoria, Sahin, Mustafa, Sarbak, Aysegul, Savas, Emre, Schattke, Constanze, Schepartz, Lynne, Selcuk, Tayfun, Sevim-Erol, Ayla, Shamoon-Pour, Michel, Shephard, Henry M, Sideris, Athanasios, Simalcsik, Angela, Simonyan, Hakob, Sinika, Vitalij, Sirak, Kendra, Sirbu, Ghenadie, Slaus, Mario, Soficaru, Andrei, Sogut, Bilal, Soltysiak, Arkadiusz, Sonmez-Sozer, Cilem, Stathi, Maria, Steskal, Martin, Stewardson, Kristin, Stocker, Sharon, Suata-Alpaslan, Fadime, Suvorov, Alexander, Szecsenyi-Nagy, Anna, Szeniczey, Tamas, Telnov, Nikolai, Temov, Strahil, Todorova, Nadezhda, Tota, Ulsi, Touchais, Gilles, Triantaphyllou, Sevi, Turker, Atila, Ugarkovic, Marina, Valchev, Todor, Veljanovska, Fancia, Videvski, Zlatko, Virag, Christian, Wagner, Anna, Walsh, Samantha, Wlodarczak, Piotr, Workman, J Noah, Yardumian, Aram, Yarovoy, Evgenii, Yavuz, Alper Yener, Yilmaz, Hakan, Zalzala, Fatma, Zettl, Anna, Zhang, Zhao, Cavusoglu, Rafet, Rohland, Nadin, Pinhasi, Ron, Reich, David, Lazaridis, Iosif, Alpaslan-Roodenberg, Songul, Acar, Ayse, Acikkol, Aysen, Agelarakis, Anagnostis, Aghikyan, Levon, Akyuz, Ugur, Andreeva, Desislava, Andrijasevic, Gojko, Anatonovic, Dragana, Armit, Ian, Atmaca, Alper, Avetisyan, Alper, Avetisyan, Pavel, Aytek, Ahmet Ihsan, Bacvarov, Krum, Badalyan, Ruben, Bakardzhiev, Stefan, Balen, Jacqueline, Bejko, Lorenc, Bernardos, Rebecca, Bertsatos, Andreas, Biber, Hanifi, Bilir, Ahmet, Brodruzic, Mario, Bonogofsky, Michelle, Bonsall, Clive, Boric, Dusan, Borovinic, Nikola, Morante, Guillermo Bravo, Buttinger, Katharina, Callan, Kim, Candilio, Francesca, Caric, Mario, Cheronet, Olivia, Chohadzhiev, Stefan, Chovalopoulou, Maria-Eleni, Chryssoulaki, Stella, Ciobanu, Ion, Condic, Natalija, Constantienescu, Mihai, Cristiani, Emanuela, Culleton, Brendan J, Curtis, Elizabeth, Davis, Jack, Davtyan, Ruben, Demcenco, Tatiana I, Dergachev, Valentin, Derin, Zafer, Deskaj, Sylvia, Devejyan, Seda, Djordjevic, Vojislav, Duffett Carlson, Kellie Sara, Eccles, Laurie R, Elenski, Nedko, Engin, Atilla, Erdogan, Nihat, Erir-Pazarci, Sabiha, Fernandes, Daniel M, Ferry, Matthew, Freilich, Suzanne, Frinculeasa, Alin, Galaty, Michael L, Gamarra, Beatriz, Gasparyan, Boris, Gaydarska, Bisserka, Genc, Elif, Gultekin, Timur, Gunduz, Serkan, Hajdu, Tamas, Heyd, Volker, Hobosyan, Suren, Hovhannisyan, Nelli, Iliev, Ilya, Iliev, Stanislav, Ivgin, Ilkay, Jankovic, Ivor, Jovanova, Lence, Karkanas, Panagiotis, Kavaz-Kindigili, Berna, Kaya, Esra Hilal, Keating, Denise, Kennett, Douglas J, Kesici, Seda Deniz, Khudaverdyan, Anahit, Kiss, Krisztian, Kilic, Sinan, Klostermann, Paul, Negra Valdes, Sniem Kostak Boca, Kovacevic, Sasa, Krenz-Niedbala, Marta, Skrivanko, Maja Krznaric, Kurti, Rovena, Kuzman, Pasko, Lawson, Ann Marie, Lazar, Catalin, Leshtakov, Krassimir, Levy, Thomas E, Liritzis, Ioannis, Lorentz, Kirsi O, Lukasik, Sylwia, Mah, Matthew, Mallick, Swapan, Mandl, Kirsten, Martirosyan-Olshansky, Kristine, Matthews, Roger, Matthews, Wendy, McSweeney, Kathleen, Melikyan, Varduhi, Micco, Adam, Michel, Megan, Milasinovic, Lidija, Mittnik, Alissa, Monge, Janet M, Nekhrizov, Georgi, Nicholls, Rebecca, Nikitin, Alexey G, Nikolov, Vassil, Novak, Mario, Olalde, Inigo, Oppenheimer, Jonas, Osterholtz, Anna, Ozdemir, Celal, Ozdogan, Kadir Toykan, Ozturk, Nurettin, Papadimitriou, Nikos, Papakonstantinou, Niki, Papathanasiou, Anastasia, Paraman, Lujana, Paskary, Evgeny G, Patterson, Nick, Petrakiev, Ilian, Petrosyan, Levon, Petrova, Vanya, Phillippa-Touchais, Anna, Piliposyan, Ashot, Pocuca Kuzman, Nada, Potrebica, Hrvoje, Preda-Balancia, Bianca, Premuzic, Zrinka, Price, T Douglas, Qiu, Lijun, Radovic, Sinisa, Raeuf Aziz, Kamal, Rajic Sikanjic, Petra, Rasheed Raheem, Kamal, Razumov, Sergei, Richardson, Amy, Roodenberg, Jacob, Ruka, Rudenc, Rasseva, Victoria, Sahin, Mustafa, Sarbak, Aysegul, Savas, Emre, Schattke, Constanze, Schepartz, Lynne, Selcuk, Tayfun, Sevim-Erol, Ayla, Shamoon-Pour, Michel, Shephard, Henry M, Sideris, Athanasios, Simalcsik, Angela, Simonyan, Hakob, Sinika, Vitalij, Sirak, Kendra, Sirbu, Ghenadie, Slaus, Mario, Soficaru, Andrei, Sogut, Bilal, Soltysiak, Arkadiusz, Sonmez-Sozer, Cilem, Stathi, Maria, Steskal, Martin, Stewardson, Kristin, Stocker, Sharon, Suata-Alpaslan, Fadime, Suvorov, Alexander, Szecsenyi-Nagy, Anna, Szeniczey, Tamas, Telnov, Nikolai, Temov, Strahil, Todorova, Nadezhda, Tota, Ulsi, Touchais, Gilles, Triantaphyllou, Sevi, Turker, Atila, Ugarkovic, Marina, Valchev, Todor, Veljanovska, Fancia, Videvski, Zlatko, Virag, Christian, Wagner, Anna, Walsh, Samantha, Wlodarczak, Piotr, Workman, J Noah, Yardumian, Aram, Yarovoy, Evgenii, Yavuz, Alper Yener, Yilmaz, Hakan, Zalzala, Fatma, Zettl, Anna, Zhang, Zhao, Cavusoglu, Rafet, Rohland, Nadin, Pinhasi, Ron, and Reich, David
Abstract: Literary and archaeological sources have preserved a rich history of Southern Europe and West Asia since the Bronze Age that can be complemented by genetics. Mycenaean period elites in Greece did not differ from the general population and included both people with some steppe ancestry and others, like the Griffin Warrior, without it. Similarly, people in the central area of the Urartian Kingdom around Lake Van lacked the steppe ancestry characteristic of the kingdom’s northern provinces. Anatolia exhibited extraordinary continuity down to the Roman and Byzantine periods, with its people serving as the demographic core of much of the Roman Empire, including the city of Rome itself. During medieval times, migrations associated with Slavic and Turkic speakers profoundly affected the region.
Published: 2022

34. Theories and molecular basis of vascular aging: a review of the literature from VascAgeNet Group on pathophysiological mechanisms of vascular aging

Author: Yalçın, Özlem (ORCID 0000-0001-5547-6653 & YÖK ID 218440), Gkaliagkousi, Eugenia; Lazaridis, Antonios; Doğan, Soner; Fraenkel, Emil; Tuna, Bilge Güvenç; Mozos, Ioana; Vukicevic, Milica; Gopcevic, Kristina, School of Medicine, Yalçın, Özlem (ORCID 0000-0001-5547-6653 & YÖK ID 218440), Gkaliagkousi, Eugenia; Lazaridis, Antonios; Doğan, Soner; Fraenkel, Emil; Tuna, Bilge Güvenç; Mozos, Ioana; Vukicevic, Milica; Gopcevic, Kristina, and School of Medicine
Abstract: Vascular aging, characterized by structural and functional alterations of the vascular wall, is a hallmark of aging and is tightly related to the development of cardiovascular mortality and age-associated vascular pathologies. Over the last years, extensive and ongoing research has highlighted several sophisticated molecular mechanisms that are involved in the pathophysiology of vascular aging. A more thorough understanding of these mechanisms could help to provide a new insight into the complex biology of this non-reversible vascular process and direct future interventions to improve longevity. In this review, we discuss the role of the most important molecular pathways involved in vascular ageing including oxidative stress, vascular inflammation, extracellular matrix metalloproteinases activity, epigenetic regulation, telomere shortening, senescence and autophagy., NA
Published: 2022

35. Effects of Age and Sex of Response to Ursodeoxycholic Acid and Transplant-free Survival in Patients With Primary Biliary Cholangitis

Author: Cheung, A, Lammers, W, Murillo Perez, C, van Buuren, H, Gulamhusein, A, Trivedi, P, Lazaridis, K, Ponsioen, C, Floreani, A, Hirschfield, G, Corpechot, C, Mayo, M, Invernizzi, P, Battezzati, P, Parés, A, Nevens, F, Thorburn, D, Mason, A, Carbone, M, Kowdley, K, Bruns, T, Dalekos, G, Gatselis, N, Verhelst, X, Lindor, K, Lleo, A, Poupon, R, Janssen, H, Hansen, B, Cheung, Angela C, Lammers, Willem J, Murillo Perez, Carla F, van Buuren, Henk R, Gulamhusein, Aliya, Trivedi, Palak J, Lazaridis, Konstantinos N, Ponsioen, Cyriel Y, Floreani, Annarosa, Hirschfield, Gideon M, Corpechot, Christophe, Mayo, Marlyn J, Invernizzi, Pietro, Battezzati, Pier Maria, Parés, Albert, Nevens, Frederik, Thorburn, Douglas, Mason, Andrew L, Carbone, Marco, Kowdley, Kris V, Bruns, Tony, Dalekos, George N, Gatselis, Nikolaos K, Verhelst, Xavier, Lindor, Keith D, Lleo, Ana, Poupon, Raoul, Janssen, Harry L, Hansen, Bettina E, Cheung, A, Lammers, W, Murillo Perez, C, van Buuren, H, Gulamhusein, A, Trivedi, P, Lazaridis, K, Ponsioen, C, Floreani, A, Hirschfield, G, Corpechot, C, Mayo, M, Invernizzi, P, Battezzati, P, Parés, A, Nevens, F, Thorburn, D, Mason, A, Carbone, M, Kowdley, K, Bruns, T, Dalekos, G, Gatselis, N, Verhelst, X, Lindor, K, Lleo, A, Poupon, R, Janssen, H, Hansen, B, Cheung, Angela C, Lammers, Willem J, Murillo Perez, Carla F, van Buuren, Henk R, Gulamhusein, Aliya, Trivedi, Palak J, Lazaridis, Konstantinos N, Ponsioen, Cyriel Y, Floreani, Annarosa, Hirschfield, Gideon M, Corpechot, Christophe, Mayo, Marlyn J, Invernizzi, Pietro, Battezzati, Pier Maria, Parés, Albert, Nevens, Frederik, Thorburn, Douglas, Mason, Andrew L, Carbone, Marco, Kowdley, Kris V, Bruns, Tony, Dalekos, George N, Gatselis, Nikolaos K, Verhelst, Xavier, Lindor, Keith D, Lleo, Ana, Poupon, Raoul, Janssen, Harry L, and Hansen, Bettina E
Abstract: Primary biliary cholangitis (PBC) predominantly affects middle-aged women; there are few data on disease phenotypes and outcomes of PBC in men and younger patients. We investigated whether differences in sex and/or age at the start of ursodeoxycholic acid (UDCA) treatment are associated with response to therapy, based on biochemical markers, or differences in transplant-free survival.
Published: 2019

36. Complete representation of action space and value in all dorsal striatal pathways

Author: Weglage, Moritz, Wärnberg, Emil, Lazaridis, Iakovos, Calvigioni, Daniela, Tzortzi, Ourania, Meletis, Konstantinos, Weglage, Moritz, Wärnberg, Emil, Lazaridis, Iakovos, Calvigioni, Daniela, Tzortzi, Ourania, and Meletis, Konstantinos
Abstract: The dorsal striatum plays a central role in the selection, execution, and evaluation of actions. An emerging model attributes action selection to the matrix and evaluation to the striosome compartment. Here, we use large-scale cell-type-specific calcium imaging to determine the activity of striatal projection neurons (SPNs) during motor and decision behaviors in the three major outputs of the dorsomedial striatum: Oprm1+ striosome versus D1+ direct and A2A+ indirect pathway SPNs. We find that Oprm1+ SPNs show complex tunings to simple movements and value-guided actions, which are conserved across many sessions in a single task but remap between contexts. During decision making, the SPN tuning profiles form a complete representation in which sequential SPN activity jointly encodes task progress and value. We propose that the three major output pathways in the dorsomedial striatum share a similarly complete representation of the entire action space, including task- and phase-specific signals of action value and choice., QC 20231101
Published: 2021
Full Text: View/download PDF

37. Complete representation of action space and value in all dorsal striatal pathways

Author: Weglage, Moritz, Wärnberg, Emil, Lazaridis, Iakovos, Calvigioni, Daniela, Tzortzi, Ourania, Meletis, Konstantinos, Weglage, Moritz, Wärnberg, Emil, Lazaridis, Iakovos, Calvigioni, Daniela, Tzortzi, Ourania, and Meletis, Konstantinos
Abstract: The dorsal striatum plays a central role in the selection, execution, and evaluation of actions. An emerging model attributes action selection to the matrix and evaluation to the striosome compartment. Here, we use large-scale cell-type-specific calcium imaging to determine the activity of striatal projection neurons (SPNs) during motor and decision behaviors in the three major outputs of the dorsomedial striatum: Oprm1+ striosome versus D1+ direct and A2A+ indirect pathway SPNs. We find that Oprm1+ SPNs show complex tunings to simple movements and value-guided actions, which are conserved across many sessions in a single task but remap between contexts. During decision making, the SPN tuning profiles form a complete representation in which sequential SPN activity jointly encodes task progress and value. We propose that the three major output pathways in the dorsomedial striatum share a similarly complete representation of the entire action space, including task- and phase-specific signals of action value and choice., QC 20231101
Published: 2021
Full Text: View/download PDF

38. Complete representation of action space and value in all dorsal striatal pathways

Author: Weglage, Moritz, Wärnberg, Emil, Lazaridis, Iakovos, Calvigioni, Daniela, Tzortzi, Ourania, Meletis, Konstantinos, Weglage, Moritz, Wärnberg, Emil, Lazaridis, Iakovos, Calvigioni, Daniela, Tzortzi, Ourania, and Meletis, Konstantinos
Abstract: The dorsal striatum plays a central role in the selection, execution, and evaluation of actions. An emerging model attributes action selection to the matrix and evaluation to the striosome compartment. Here, we use large-scale cell-type-specific calcium imaging to determine the activity of striatal projection neurons (SPNs) during motor and decision behaviors in the three major outputs of the dorsomedial striatum: Oprm1+ striosome versus D1+ direct and A2A+ indirect pathway SPNs. We find that Oprm1+ SPNs show complex tunings to simple movements and value-guided actions, which are conserved across many sessions in a single task but remap between contexts. During decision making, the SPN tuning profiles form a complete representation in which sequential SPN activity jointly encodes task progress and value. We propose that the three major output pathways in the dorsomedial striatum share a similarly complete representation of the entire action space, including task- and phase-specific signals of action value and choice., QC 20231101
Published: 2021
Full Text: View/download PDF

39. An international genome-wide meta-analysis of primary biliary cholangitis: novel risk loci and candidate drugs

Author: 90396862, Cordell, Heather J., Fryett, James J., Ueno, Kazuko, Darlay, Rebecca, Aiba, Yoshihiro, Hitomi, Yuki, Kawashima, Minae, Nishida, Nao, Khor, Seik-Soon, Gervais, Olivier, Kawai, Yosuke, Nagasaki, Masao, Tokunaga, Katsushi, Tang, Ruqi, Shi, Yongyong, Li, Zhiqiang, Juran, Brian D., Atkinson, Elizabeth J., Gerussi, Alessio, Carbone, Marco, Asselta, Rosanna, Cheung, Angela, de Andrade, Mariza, Baras, Aris, Horowitz, Julie, Ferreira, Manuel A.R., Sun, Dylan, Jones, David E., Flack, Steven, Spicer, Ann, Mulcahy, Victoria L., Byan, Jinyoung, Han, Younghun, Sandford, Richard N., Lazaridis, Konstantinos N., Amos, Christopher I., Hirschfield, Gideon M., Seldin, Michael F., Invernizzi, Pietro, Siminovitch, Katherine A., Ma, Xiong, Nakamura, Minoru, Mells, George F., Canadian PBC Consortium, Chinese PBC Consortium, Italian PBC Study Group, Japan-PBC-GWAS Consortium, US PBC Consortium, UK-PBC Consortium, 90396862, Cordell, Heather J., Fryett, James J., Ueno, Kazuko, Darlay, Rebecca, Aiba, Yoshihiro, Hitomi, Yuki, Kawashima, Minae, Nishida, Nao, Khor, Seik-Soon, Gervais, Olivier, Kawai, Yosuke, Nagasaki, Masao, Tokunaga, Katsushi, Tang, Ruqi, Shi, Yongyong, Li, Zhiqiang, Juran, Brian D., Atkinson, Elizabeth J., Gerussi, Alessio, Carbone, Marco, Asselta, Rosanna, Cheung, Angela, de Andrade, Mariza, Baras, Aris, Horowitz, Julie, Ferreira, Manuel A.R., Sun, Dylan, Jones, David E., Flack, Steven, Spicer, Ann, Mulcahy, Victoria L., Byan, Jinyoung, Han, Younghun, Sandford, Richard N., Lazaridis, Konstantinos N., Amos, Christopher I., Hirschfield, Gideon M., Seldin, Michael F., Invernizzi, Pietro, Siminovitch, Katherine A., Ma, Xiong, Nakamura, Minoru, Mells, George F., Canadian PBC Consortium, Chinese PBC Consortium, Italian PBC Study Group, Japan-PBC-GWAS Consortium, US PBC Consortium, and UK-PBC Consortium
Abstract: [BACKGROUND & AIMS] Primary biliary cholangitis (PBC) is a chronic liver disease in which autoimmune destruction of the small intra-hepatic bile ducts eventually leads to cirrhosis. Many patients have inadequate response to licensed medications, motivating the search for novel therapies. Previous genome-wide association studies (GWAS) and meta-analyses (GWMA) of PBC have identified numerous risk loci for this condition, providing insight into its aetiology. We undertook the largest GWMA of PBC to date, aiming to identify additional risk loci and prioritise candidate genes for in silico drug efficacy screening. [METHODS] We combined new and existing genotype data for 10, 516 cases and 20, 772 controls from five European and two East Asian cohorts. [RESULTS] We identified 56 genome-wide significant loci (20 novel) including 46 in European, 13 in Asian, and 41 in combined cohorts; and a 57th genome-wide significant locus (also novel) in conditional analysis of the European cohorts. Candidate genes at newly identified loci include FCRL3, INAVA, PRDM1, IRF7, CCR6, CD226, and IL12RB1, each having key roles in immunity. Pathway analysis reiterated the likely importance of pattern recognition receptor and TNF signalling, Jak-STAT signalling, and differentiation of TH1 and TH17 cells in the pathogenesis of this disease. Drug efficacy screening identified several medications predicted to be therapeutic in PBC, some well-established in the treatment of other autoimmune disorders. [CONCLUSIONS] This study has identified additional risk loci for PBC, provided a hierarchy of agents that could be trialled in this condition, and emphasised the value of genetic and genomic approaches to drug discovery in complex disorders. [Lay summary] Primary biliary cholangitis (PBC) is a chronic liver disease that eventually leads to cirrhosis. In this study, we analysed genetic information from 10, 516 people with PBC and 20, 772 healthy individuals recruited in Canada, China, Italy, Japan, UK
Published: 2021

40. Large-scale migration into Britain during the Middle to Late Bronze Age

Author: Patterson, Nick, Isakov, Michael, Booth, Thomas, Büster, Lindsey, Fischer, Claire-Elise, Olalde, Iñigo, Ringbauer, Harald, Akbari, Ali, Cheronet, Olivia, Bleasdale, Madeleine, Adamski, Nicole, Altena, Eveline, Bernardos, Rebecca, Brace, Selina, Broomandkhoshbacht, Nasreen, Callan, Kimberly, Candilio, Francesca, Culleton, Brendan, Curtis, Elizabeth, Demetz, Lea, Carlson, Kellie Sara Duffett, Fernandes, Daniel M, Foody, M George B, Freilich, Suzanne, Goodchild, Helen, Kearns, Aisling, Lawson, Ann Marie, Lazaridis, Iosif, Mah, Matthew, Mallick, Swapan, Mandl, Kirsten, Micco, Adam, Michel, Megan, Morante, Guillermo Bravo, Oppenheimer, Jonas, Özdoğan, Kadir Toykan, Qiu, Lijun, Schattke, Constanze, Stewardson, Kristin, Workman, J Noah, Zalzala, Fatma, Zhang, Zhao, Agustí, Bibiana, Allen, Tim, Almássy, Katalin, Amkreutz, Luc, Ash, Abigail, Baillif-Ducros, Christèle, Barclay, Alistair, Bartosiewicz, László, Baxter, Katherine, Bernert, Zsolt, Blažek, Jan, Bodružić, Mario, Boissinot, Philippe, Bonsall, Clive, Bradley, Pippa, Brittain, Marcus, Brookes, Alison, Brown, Fraser, Brown, Lisa, Brunning, Richard, Budd, Chelsea, Burmaz, Josip, Canet, Sylvain, Carnicero-Cáceres, Silvia, Čaušević-Bully, Morana, Chamberlain, Andrew, Chauvin, Sébastien, Clough, Sharon, Čondić, Natalija, Coppa, Alfredo, Craig, Oliver, Črešnar, Matija, Cummings, Vicki, Czifra, Szabolcs, Danielisová, Alžběta, Daniels, Robin, Davies, Alex, de Jersey, Philip, Deacon, Jody, Deminger, Csilla, Ditchfield, Peter W, Dizdar, Marko, Dobeš, Miroslav, Dobisíková, Miluše, Domboróczki, László, Drinkall, Gail, Đukić, Ana, Edwards, Ceiridwen J, Ernée, Michal, Evans, Christopher, Evans, Jane, Fernández-Götz, Manuel, Filipović, Slavica, Fitzpatrick, Andrew, Fokkens, Harry, Fowler, Chris, Fox, Allison, Gallina, Zsolt, Gamble, Michelle, González Morales, Manuel R, González-Rabanal, Borja, Green, Adrian, Gyenesei, Katalin, Habermehl, Diederick, Hajdu, Tamás, Hamilton, Derek, Harris, James, Hayden, Chris, Hendriks, Joep, Hernu, Bénédicte, Hey, Gill, Horňák, Milan, Ilon, Gábor, Istvánovits, Eszter, Jones, Andy M, Kavur, Martina Blečić, Kazek, Kevin, Kenyon, Robert A, Khreisheh, Amal, Kiss, Viktória, Kleijne, Jos, Knight, Mark, Kootker, Lisette M, Kovács, Péter F, Kozubová, Anita, Kulcsár, Gabriella, Kulcsár, Valéria, Le Pennec, Christophe, Legge, Michael, Leivers, Matt, Loe, Louise, López-Costas, Olalla, Lord, Tom, Los, Dženi, Lyall, James, Marín-Arroyo, Ana B, Mason, Philip, Matošević, Damir, Maxted, Andy, McIntyre, Lauren, McKinley, Jacqueline, McSweeney, Kathleen, Meijlink, Bernard, Mende, Balázs G, Menđušić, Marko, Metlička, Milan, Meyer, Sophie, Mihovilić, Kristina, Milasinovic, Lidija, Minnitt, Steve, Moore, Joanna, Morley, Geoff, Mullan, Graham, Musilová, Margaréta, Neil, Benjamin, Nicholls, Rebecca, Novak, Mario, Pala, Maria, Papworth, Martin, Paresys, Cécile, Patten, Ricky, Perkić, Domagoj, Pesti, Krisztina, Petit, Alba, Petriščáková, Katarína, Pichon, Coline, Pickard, Catriona, Pilling, Zoltán, Price, T Douglas, Radović, Siniša, Redfern, Rebecca, Resutík, Branislav, Rhodes, Daniel T, Richards, Martin B, Roberts, Amy, Roefstra, Jean, Sankot, Pavel, Šefčáková, Alena, Sheridan, Alison, Skae, Sabine, Šmolíková, Miroslava, Somogyi, Krisztina, Somogyvári, Ágnes, Stephens, Mark, Szabó, Géza, Szécsényi-Nagy, Anna, Szeniczey, Tamás, Tabor, Jonathan, Tankó, Károly, Maria, Clenis Tavarez, Terry, Rachel, Teržan, Biba, Teschler-Nicola, Maria, Torres-Martínez, Jesús F, Trapp, Julien, Turle, Ross, Ujvári, Ferenc, van der Heiden, Menno, Veleminsky, Petr, Veselka, Barbara, Vytlačil, Zdeněk, Waddington, Clive, Ware, Paula, Wilkinson, Paul, Wilson, Linda, Wiseman, Rob, Young, Eilidh, Zaninović, Joško, Žitňan, Andrej, Lalueza-Fox, Carles, de Knijff, Peter, Barnes, Ian, Halkon, Peter, Thomas, Mark G, Kennett, Douglas J, Cunliffe, Barry, Lillie, Malcolm, Rohland, Nadin, Pinhasi, Ron, Armit, Ian, Reich, David, Patterson, Nick, Isakov, Michael, Booth, Thomas, Büster, Lindsey, Fischer, Claire-Elise, Olalde, Iñigo, Ringbauer, Harald, Akbari, Ali, Cheronet, Olivia, Bleasdale, Madeleine, Adamski, Nicole, Altena, Eveline, Bernardos, Rebecca, Brace, Selina, Broomandkhoshbacht, Nasreen, Callan, Kimberly, Candilio, Francesca, Culleton, Brendan, Curtis, Elizabeth, Demetz, Lea, Carlson, Kellie Sara Duffett, Fernandes, Daniel M, Foody, M George B, Freilich, Suzanne, Goodchild, Helen, Kearns, Aisling, Lawson, Ann Marie, Lazaridis, Iosif, Mah, Matthew, Mallick, Swapan, Mandl, Kirsten, Micco, Adam, Michel, Megan, Morante, Guillermo Bravo, Oppenheimer, Jonas, Özdoğan, Kadir Toykan, Qiu, Lijun, Schattke, Constanze, Stewardson, Kristin, Workman, J Noah, Zalzala, Fatma, Zhang, Zhao, Agustí, Bibiana, Allen, Tim, Almássy, Katalin, Amkreutz, Luc, Ash, Abigail, Baillif-Ducros, Christèle, Barclay, Alistair, Bartosiewicz, László, Baxter, Katherine, Bernert, Zsolt, Blažek, Jan, Bodružić, Mario, Boissinot, Philippe, Bonsall, Clive, Bradley, Pippa, Brittain, Marcus, Brookes, Alison, Brown, Fraser, Brown, Lisa, Brunning, Richard, Budd, Chelsea, Burmaz, Josip, Canet, Sylvain, Carnicero-Cáceres, Silvia, Čaušević-Bully, Morana, Chamberlain, Andrew, Chauvin, Sébastien, Clough, Sharon, Čondić, Natalija, Coppa, Alfredo, Craig, Oliver, Črešnar, Matija, Cummings, Vicki, Czifra, Szabolcs, Danielisová, Alžběta, Daniels, Robin, Davies, Alex, de Jersey, Philip, Deacon, Jody, Deminger, Csilla, Ditchfield, Peter W, Dizdar, Marko, Dobeš, Miroslav, Dobisíková, Miluše, Domboróczki, László, Drinkall, Gail, Đukić, Ana, Edwards, Ceiridwen J, Ernée, Michal, Evans, Christopher, Evans, Jane, Fernández-Götz, Manuel, Filipović, Slavica, Fitzpatrick, Andrew, Fokkens, Harry, Fowler, Chris, Fox, Allison, Gallina, Zsolt, Gamble, Michelle, González Morales, Manuel R, González-Rabanal, Borja, Green, Adrian, Gyenesei, Katalin, Habermehl, Diederick, Hajdu, Tamás, Hamilton, Derek, Harris, James, Hayden, Chris, Hendriks, Joep, Hernu, Bénédicte, Hey, Gill, Horňák, Milan, Ilon, Gábor, Istvánovits, Eszter, Jones, Andy M, Kavur, Martina Blečić, Kazek, Kevin, Kenyon, Robert A, Khreisheh, Amal, Kiss, Viktória, Kleijne, Jos, Knight, Mark, Kootker, Lisette M, Kovács, Péter F, Kozubová, Anita, Kulcsár, Gabriella, Kulcsár, Valéria, Le Pennec, Christophe, Legge, Michael, Leivers, Matt, Loe, Louise, López-Costas, Olalla, Lord, Tom, Los, Dženi, Lyall, James, Marín-Arroyo, Ana B, Mason, Philip, Matošević, Damir, Maxted, Andy, McIntyre, Lauren, McKinley, Jacqueline, McSweeney, Kathleen, Meijlink, Bernard, Mende, Balázs G, Menđušić, Marko, Metlička, Milan, Meyer, Sophie, Mihovilić, Kristina, Milasinovic, Lidija, Minnitt, Steve, Moore, Joanna, Morley, Geoff, Mullan, Graham, Musilová, Margaréta, Neil, Benjamin, Nicholls, Rebecca, Novak, Mario, Pala, Maria, Papworth, Martin, Paresys, Cécile, Patten, Ricky, Perkić, Domagoj, Pesti, Krisztina, Petit, Alba, Petriščáková, Katarína, Pichon, Coline, Pickard, Catriona, Pilling, Zoltán, Price, T Douglas, Radović, Siniša, Redfern, Rebecca, Resutík, Branislav, Rhodes, Daniel T, Richards, Martin B, Roberts, Amy, Roefstra, Jean, Sankot, Pavel, Šefčáková, Alena, Sheridan, Alison, Skae, Sabine, Šmolíková, Miroslava, Somogyi, Krisztina, Somogyvári, Ágnes, Stephens, Mark, Szabó, Géza, Szécsényi-Nagy, Anna, Szeniczey, Tamás, Tabor, Jonathan, Tankó, Károly, Maria, Clenis Tavarez, Terry, Rachel, Teržan, Biba, Teschler-Nicola, Maria, Torres-Martínez, Jesús F, Trapp, Julien, Turle, Ross, Ujvári, Ferenc, van der Heiden, Menno, Veleminsky, Petr, Veselka, Barbara, Vytlačil, Zdeněk, Waddington, Clive, Ware, Paula, Wilkinson, Paul, Wilson, Linda, Wiseman, Rob, Young, Eilidh, Zaninović, Joško, Žitňan, Andrej, Lalueza-Fox, Carles, de Knijff, Peter, Barnes, Ian, Halkon, Peter, Thomas, Mark G, Kennett, Douglas J, Cunliffe, Barry, Lillie, Malcolm, Rohland, Nadin, Pinhasi, Ron, Armit, Ian, and Reich, David
Abstract: Present-day people from England and Wales harbour more ancestry derived from Early European Farmers (EEF) than people of the Early Bronze Age . To understand this, we generated genome-wide data from 793 individuals, increasing data from the Middle to Late Bronze and Iron Age in Britain by 12-fold, and Western and Central Europe by 3.5-fold. Between 1000 and 875 BC, EEF ancestry increased in southern Britain (England and Wales) but not northern Britain (Scotland) due to incorporation of migrants who arrived at this time and over previous centuries, and who were genetically most similar to ancient individuals from France. These migrants contributed about half the ancestry of Iron Age people of England and Wales, thereby creating a plausible vector for the spread of early Celtic languages into Britain. These patterns are part of a broader trend of EEF ancestry becoming more similar across central and western Europe in the Middle to Late Bronze Age, coincident with archaeological evidence of intensified cultural exchange . There was comparatively less gene flow from continental Europe during the Iron Age, and Britain's independent genetic trajectory is also reflected in the rise of the allele conferring lactase persistence to ~50% by this time compared to ~7% in central Europe where it rose rapidly in frequency only a millennium later. This suggests that dairy products were used in qualitatively different ways in Britain and in central Europe over this period. [Abstract copyright: © 2021. The Author(s), under exclusive licence to Springer Nature Limited.]
Published: 2021

41. Large-scale migration into Britain during the Middle to Late Bronze Age

Author: Patterson, Nick, Isakov, Michael, Booth, Thomas, Büster, Lindsey, Fischer, Claire-Elise, Olalde, Iñigo, Ringbauer, Harald, Akbari, Ali, Cheronet, Olivia, Bleasdale, Madeleine, Adamski, Nicole, Altena, Eveline, Bernardos, Rebecca, Brace, Selina, Broomandkhoshbacht, Nasreen, Callan, Kimberly, Candilio, Francesca, Culleton, Brendan, Curtis, Elizabeth, Demetz, Lea, Carlson, Kellie Sara Duffett, Fernandes, Daniel M, Foody, M George B, Freilich, Suzanne, Goodchild, Helen, Kearns, Aisling, Lawson, Ann Marie, Lazaridis, Iosif, Mah, Matthew, Mallick, Swapan, Mandl, Kirsten, Micco, Adam, Michel, Megan, Morante, Guillermo Bravo, Oppenheimer, Jonas, Özdoğan, Kadir Toykan, Qiu, Lijun, Schattke, Constanze, Stewardson, Kristin, Workman, J Noah, Zalzala, Fatma, Zhang, Zhao, Agustí, Bibiana, Allen, Tim, Almássy, Katalin, Amkreutz, Luc, Ash, Abigail, Baillif-Ducros, Christèle, Barclay, Alistair, Bartosiewicz, László, Baxter, Katherine, Bernert, Zsolt, Blažek, Jan, Bodružić, Mario, Boissinot, Philippe, Bonsall, Clive, Bradley, Pippa, Brittain, Marcus, Brookes, Alison, Brown, Fraser, Brown, Lisa, Brunning, Richard, Budd, Chelsea, Burmaz, Josip, Canet, Sylvain, Carnicero-Cáceres, Silvia, Čaušević-Bully, Morana, Chamberlain, Andrew, Chauvin, Sébastien, Clough, Sharon, Čondić, Natalija, Coppa, Alfredo, Craig, Oliver, Črešnar, Matija, Cummings, Vicki, Czifra, Szabolcs, Danielisová, Alžběta, Daniels, Robin, Davies, Alex, de Jersey, Philip, Deacon, Jody, Deminger, Csilla, Ditchfield, Peter W, Dizdar, Marko, Dobeš, Miroslav, Dobisíková, Miluše, Domboróczki, László, Drinkall, Gail, Đukić, Ana, Edwards, Ceiridwen J, Ernée, Michal, Evans, Christopher, Evans, Jane, Fernández-Götz, Manuel, Filipović, Slavica, Fitzpatrick, Andrew, Fokkens, Harry, Fowler, Chris, Fox, Allison, Gallina, Zsolt, Gamble, Michelle, González Morales, Manuel R, González-Rabanal, Borja, Green, Adrian, Gyenesei, Katalin, Habermehl, Diederick, Hajdu, Tamás, Hamilton, Derek, Harris, James, Hayden, Chris, Hendriks, Joep, Hernu, Bénédicte, Hey, Gill, Horňák, Milan, Ilon, Gábor, Istvánovits, Eszter, Jones, Andy M, Kavur, Martina Blečić, Kazek, Kevin, Kenyon, Robert A, Khreisheh, Amal, Kiss, Viktória, Kleijne, Jos, Knight, Mark, Kootker, Lisette M, Kovács, Péter F, Kozubová, Anita, Kulcsár, Gabriella, Kulcsár, Valéria, Le Pennec, Christophe, Legge, Michael, Leivers, Matt, Loe, Louise, López-Costas, Olalla, Lord, Tom, Los, Dženi, Lyall, James, Marín-Arroyo, Ana B, Mason, Philip, Matošević, Damir, Maxted, Andy, McIntyre, Lauren, McKinley, Jacqueline, McSweeney, Kathleen, Meijlink, Bernard, Mende, Balázs G, Menđušić, Marko, Metlička, Milan, Meyer, Sophie, Mihovilić, Kristina, Milasinovic, Lidija, Minnitt, Steve, Moore, Joanna, Morley, Geoff, Mullan, Graham, Musilová, Margaréta, Neil, Benjamin, Nicholls, Rebecca, Novak, Mario, Pala, Maria, Papworth, Martin, Paresys, Cécile, Patten, Ricky, Perkić, Domagoj, Pesti, Krisztina, Petit, Alba, Petriščáková, Katarína, Pichon, Coline, Pickard, Catriona, Pilling, Zoltán, Price, T Douglas, Radović, Siniša, Redfern, Rebecca, Resutík, Branislav, Rhodes, Daniel T, Richards, Martin B, Roberts, Amy, Roefstra, Jean, Sankot, Pavel, Šefčáková, Alena, Sheridan, Alison, Skae, Sabine, Šmolíková, Miroslava, Somogyi, Krisztina, Somogyvári, Ágnes, Stephens, Mark, Szabó, Géza, Szécsényi-Nagy, Anna, Szeniczey, Tamás, Tabor, Jonathan, Tankó, Károly, Maria, Clenis Tavarez, Terry, Rachel, Teržan, Biba, Teschler-Nicola, Maria, Torres-Martínez, Jesús F, Trapp, Julien, Turle, Ross, Ujvári, Ferenc, van der Heiden, Menno, Veleminsky, Petr, Veselka, Barbara, Vytlačil, Zdeněk, Waddington, Clive, Ware, Paula, Wilkinson, Paul, Wilson, Linda, Wiseman, Rob, Young, Eilidh, Zaninović, Joško, Žitňan, Andrej, Lalueza-Fox, Carles, de Knijff, Peter, Barnes, Ian, Halkon, Peter, Thomas, Mark G, Kennett, Douglas J, Cunliffe, Barry, Lillie, Malcolm, Rohland, Nadin, Pinhasi, Ron, Armit, Ian, Reich, David, Patterson, Nick, Isakov, Michael, Booth, Thomas, Büster, Lindsey, Fischer, Claire-Elise, Olalde, Iñigo, Ringbauer, Harald, Akbari, Ali, Cheronet, Olivia, Bleasdale, Madeleine, Adamski, Nicole, Altena, Eveline, Bernardos, Rebecca, Brace, Selina, Broomandkhoshbacht, Nasreen, Callan, Kimberly, Candilio, Francesca, Culleton, Brendan, Curtis, Elizabeth, Demetz, Lea, Carlson, Kellie Sara Duffett, Fernandes, Daniel M, Foody, M George B, Freilich, Suzanne, Goodchild, Helen, Kearns, Aisling, Lawson, Ann Marie, Lazaridis, Iosif, Mah, Matthew, Mallick, Swapan, Mandl, Kirsten, Micco, Adam, Michel, Megan, Morante, Guillermo Bravo, Oppenheimer, Jonas, Özdoğan, Kadir Toykan, Qiu, Lijun, Schattke, Constanze, Stewardson, Kristin, Workman, J Noah, Zalzala, Fatma, Zhang, Zhao, Agustí, Bibiana, Allen, Tim, Almássy, Katalin, Amkreutz, Luc, Ash, Abigail, Baillif-Ducros, Christèle, Barclay, Alistair, Bartosiewicz, László, Baxter, Katherine, Bernert, Zsolt, Blažek, Jan, Bodružić, Mario, Boissinot, Philippe, Bonsall, Clive, Bradley, Pippa, Brittain, Marcus, Brookes, Alison, Brown, Fraser, Brown, Lisa, Brunning, Richard, Budd, Chelsea, Burmaz, Josip, Canet, Sylvain, Carnicero-Cáceres, Silvia, Čaušević-Bully, Morana, Chamberlain, Andrew, Chauvin, Sébastien, Clough, Sharon, Čondić, Natalija, Coppa, Alfredo, Craig, Oliver, Črešnar, Matija, Cummings, Vicki, Czifra, Szabolcs, Danielisová, Alžběta, Daniels, Robin, Davies, Alex, de Jersey, Philip, Deacon, Jody, Deminger, Csilla, Ditchfield, Peter W, Dizdar, Marko, Dobeš, Miroslav, Dobisíková, Miluše, Domboróczki, László, Drinkall, Gail, Đukić, Ana, Edwards, Ceiridwen J, Ernée, Michal, Evans, Christopher, Evans, Jane, Fernández-Götz, Manuel, Filipović, Slavica, Fitzpatrick, Andrew, Fokkens, Harry, Fowler, Chris, Fox, Allison, Gallina, Zsolt, Gamble, Michelle, González Morales, Manuel R, González-Rabanal, Borja, Green, Adrian, Gyenesei, Katalin, Habermehl, Diederick, Hajdu, Tamás, Hamilton, Derek, Harris, James, Hayden, Chris, Hendriks, Joep, Hernu, Bénédicte, Hey, Gill, Horňák, Milan, Ilon, Gábor, Istvánovits, Eszter, Jones, Andy M, Kavur, Martina Blečić, Kazek, Kevin, Kenyon, Robert A, Khreisheh, Amal, Kiss, Viktória, Kleijne, Jos, Knight, Mark, Kootker, Lisette M, Kovács, Péter F, Kozubová, Anita, Kulcsár, Gabriella, Kulcsár, Valéria, Le Pennec, Christophe, Legge, Michael, Leivers, Matt, Loe, Louise, López-Costas, Olalla, Lord, Tom, Los, Dženi, Lyall, James, Marín-Arroyo, Ana B, Mason, Philip, Matošević, Damir, Maxted, Andy, McIntyre, Lauren, McKinley, Jacqueline, McSweeney, Kathleen, Meijlink, Bernard, Mende, Balázs G, Menđušić, Marko, Metlička, Milan, Meyer, Sophie, Mihovilić, Kristina, Milasinovic, Lidija, Minnitt, Steve, Moore, Joanna, Morley, Geoff, Mullan, Graham, Musilová, Margaréta, Neil, Benjamin, Nicholls, Rebecca, Novak, Mario, Pala, Maria, Papworth, Martin, Paresys, Cécile, Patten, Ricky, Perkić, Domagoj, Pesti, Krisztina, Petit, Alba, Petriščáková, Katarína, Pichon, Coline, Pickard, Catriona, Pilling, Zoltán, Price, T Douglas, Radović, Siniša, Redfern, Rebecca, Resutík, Branislav, Rhodes, Daniel T, Richards, Martin B, Roberts, Amy, Roefstra, Jean, Sankot, Pavel, Šefčáková, Alena, Sheridan, Alison, Skae, Sabine, Šmolíková, Miroslava, Somogyi, Krisztina, Somogyvári, Ágnes, Stephens, Mark, Szabó, Géza, Szécsényi-Nagy, Anna, Szeniczey, Tamás, Tabor, Jonathan, Tankó, Károly, Maria, Clenis Tavarez, Terry, Rachel, Teržan, Biba, Teschler-Nicola, Maria, Torres-Martínez, Jesús F, Trapp, Julien, Turle, Ross, Ujvári, Ferenc, van der Heiden, Menno, Veleminsky, Petr, Veselka, Barbara, Vytlačil, Zdeněk, Waddington, Clive, Ware, Paula, Wilkinson, Paul, Wilson, Linda, Wiseman, Rob, Young, Eilidh, Zaninović, Joško, Žitňan, Andrej, Lalueza-Fox, Carles, de Knijff, Peter, Barnes, Ian, Halkon, Peter, Thomas, Mark G, Kennett, Douglas J, Cunliffe, Barry, Lillie, Malcolm, Rohland, Nadin, Pinhasi, Ron, Armit, Ian, and Reich, David
Abstract: Present-day people from England and Wales harbour more ancestry derived from Early European Farmers (EEF) than people of the Early Bronze Age . To understand this, we generated genome-wide data from 793 individuals, increasing data from the Middle to Late Bronze and Iron Age in Britain by 12-fold, and Western and Central Europe by 3.5-fold. Between 1000 and 875 BC, EEF ancestry increased in southern Britain (England and Wales) but not northern Britain (Scotland) due to incorporation of migrants who arrived at this time and over previous centuries, and who were genetically most similar to ancient individuals from France. These migrants contributed about half the ancestry of Iron Age people of England and Wales, thereby creating a plausible vector for the spread of early Celtic languages into Britain. These patterns are part of a broader trend of EEF ancestry becoming more similar across central and western Europe in the Middle to Late Bronze Age, coincident with archaeological evidence of intensified cultural exchange . There was comparatively less gene flow from continental Europe during the Iron Age, and Britain's independent genetic trajectory is also reflected in the rise of the allele conferring lactase persistence to ~50% by this time compared to ~7% in central Europe where it rose rapidly in frequency only a millennium later. This suggests that dairy products were used in qualitatively different ways in Britain and in central Europe over this period. [Abstract copyright: © 2021. The Author(s), under exclusive licence to Springer Nature Limited.]
Published: 2021

42. OCT Signal Enhancement with Deep Learning.

Author: Lazaridis, G, Lorenzi, M, Mohamed-Noriega, J, Aguilar-Munoa, S, Suzuki, K, Nomoto, H, Ourselin, S, Garway-Heath, DF, United Kingdom Glaucoma Treatment Study Investigators, Lazaridis, G, Lorenzi, M, Mohamed-Noriega, J, Aguilar-Munoa, S, Suzuki, K, Nomoto, H, Ourselin, S, Garway-Heath, DF, and United Kingdom Glaucoma Treatment Study Investigators
Abstract: PURPOSE: To establish whether deep learning methods are able to improve the signal-to-noise ratio of time-domain (TD) OCT images to approach that of spectral-domain (SD) OCT images. DESIGN: Method agreement study and progression detection in a randomized, double-masked, placebo-controlled, multicenter trial for open-angle glaucoma (OAG), the United Kingdom Glaucoma Treatment Study (UKGTS). PARTICIPANTS: The training and validation cohort comprised 77 stable OAG participants with TD OCT and SD OCT imaging at up to 11 visits within 3 months. The testing cohort comprised 284 newly diagnosed OAG patients with TD OCT images from a cohort of 516 recruited at 10 United Kingdom centers between 2007 and 2010. METHODS: An ensemble of generative adversarial networks (GANs) was trained on TD OCT and SD OCT image pairs from the training dataset and applied to TD OCT images from the testing dataset. Time-domain OCT images were converted to synthesized SD OCT images and segmented via Bayesian fusion on the output of the GANs. MAIN OUTCOME MEASURES: Bland-Altman analysis assessed agreement between TD OCT and synthesized SD OCT average retinal nerve fiber layer thickness (RNFLT) measurements and the SD OCT RNFLT. Analysis of the distribution of the rates of RNFLT change in TD OCT and synthesized SD OCT in the two treatment arms of the UKGTS was compared. A Cox model for predictors of time-to-incident visual field (VF) progression was computed with the TD OCT and the synthesized SD OCT images. RESULTS: The 95% limits of agreement were between TD OCT and SD OCT were 26.64 to -22.95; between synthesized SD OCT and SD OCT were 8.11 to -6.73; and between SD OCT and SD OCT were 4.16 to -4.04. The mean difference in the rate of RNFLT change between UKGTS treatment and placebo arms with TD OCT was 0.24 (P = 0.11) and with synthesized SD OCT was 0.43 (P = 0.0017). The hazard ratio for RNFLT slope in Cox regression modeling for time to incident VF progression was 1.09 (95% confidence interval
Published: 2021

43. Circular economy in the building industry : Innovation as an incentive and its link to company growth

Author: Narin, Fabian, Lazaridis, Georgios Petros, Narin, Fabian, and Lazaridis, Georgios Petros
Abstract: Background: The building industry is slowly but progressively shifting from the ‘take-make-dispose’principle of the linear economy towards a circular economy (CE), where waste is minimized and reintroduced to the loop of production. In this way, the loop of materials, energy and waste flows is closed; all for the hopes of saving the environment. Nonetheless, studies show that this is not the main incentivefor which architects and engineers implement CE principles into their projects and businesses but rather because they are interested in the innovative aspect of CE (Alhawari, et al., 2021). Previous research has also shown that there is a positive correlation between this innovation incentive and the growth thata company has experienced over the years (Horbach & Rammer, 2020). Innovation as such allows companies to attain competitiveness and make their presence stronger in the market (Raghuvanshi & Agrawal, 2020). Objectives: The objective is to extend previous studies about innovation being the main incentivedriving the implementation of CE principles in the building industry. Furthermore, the relationship between company growth and the strength of the innovation incentive is studied, as well as the relationship between company growth and the number of CE projects a company has worked on over the last years. Methodology: The study is based on a quantitative approach for data collection and data analysis. The data comes from 70 architectural and engineering companies operating in various countries of the European Union and is analyzed with the help of descriptive statistics and Mann-Whitney U tests through STATA software. Results: Innovation is proved to be the main incentive, driving the transition towards CE in the building industry; it is also clearly proven that there is a positive correlation between the innovation incentiveand the company growth. Diving deeper into the subject, no correlation was found between the numberof CE projects and the compan
Published: 2021

44. The inclination for a preference.

Author: Lazaridis, Georgios and Lazaridis, Georgios
Abstract: In this essay I have playfully ventured to rediscover what I might know about art,what has been formed and blended all this time inside my mind, by the sources,influences, readings, references I have come across. Partially to answer to myselfwhere is my trajectory, where is it headed, and in that tracing hopefully, I willprovide a short reading here about what I think is art, and how I approach it.So, one can start from a simple question, at which one does not care to concludewith an answer: "why do we mark/trace a surface? Or for that matter, sculpt, think,animate etc." What is the inclination behind it? And more importantly, why do wecling to a specific preference?” My work consists of two parts: of the one which is here, and of everything whichI have not written. And precisely this second part is the important one.”-Wittgenstein
Published: 2021

45. Safety, Antitumor Activity, and T-cell Responses in a Dose-Ranging Phase I Trial of the Oncolytic Peptide LTX-315 in Patients with Solid Tumors.

Author: UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie, Spicer, James, Marabelle, Aurélien, Baurain, Jean-François, Jebsen, Nina Louise, Jøssang, Dag Erik, Awada, Ahmad, Kristeleit, Rebecca, Loirat, Delphine, Lazaridis, George, Jungels, Christiane, Brunsvig, Paal, Nicolaisen, Berit, Saunders, Andrew, Patel, Hamina, Galon, Jérôme, Hermitte, Fabienne, Camilio, Ketil André, Mauseth, Brynjar, Sundvold, Vibeke, Sveinbjørnsson, Baldur, Rekdal, Øystein, UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie, Spicer, James, Marabelle, Aurélien, Baurain, Jean-François, Jebsen, Nina Louise, Jøssang, Dag Erik, Awada, Ahmad, Kristeleit, Rebecca, Loirat, Delphine, Lazaridis, George, Jungels, Christiane, Brunsvig, Paal, Nicolaisen, Berit, Saunders, Andrew, Patel, Hamina, Galon, Jérôme, Hermitte, Fabienne, Camilio, Ketil André, Mauseth, Brynjar, Sundvold, Vibeke, Sveinbjørnsson, Baldur, and Rekdal, Øystein
Abstract: LTX-315 is a first-in-class, 9-mer membranolytic peptide that has shown potent immunomodulatory properties in preclinical models. We conducted a phase I dose-escalating study of intratumoral LTX-315 administration in patients with advanced solid tumors. Thirty-nine patients were enrolled, receiving LTX-315 injections into accessible tumors. The primary objective was to assess the safety and tolerability of this approach, with antitumor and immunomodulatory activity as secondary objectives. Tumor biopsies were collected at baseline and posttreatment for analysis of immunologic parameters. The most common treatment-related grade 1-2 adverse events were vascular disorders including transient hypotension (18 patients, 46%), flushing (11 patients, 28%), and injection site reactions in 38% of patients. The most common grade 3 LTX-315-related toxicities were hypersensitivity or anaphylaxis (4 patients, 10%). Analysis of immune endpoints in serial biopsies indicated that LTX-315 induces necrosis and CD8 T-cell infiltration into the tumor microenvironment. Sequencing of the T-cell receptor repertoire in peripheral blood identified significant expansion of T-cell clones after treatment, of which 49% were present in available tumor biopsies after treatment, suggesting that they were tumor associated. Substantial volume reduction (≥30%) of injected tumors occurred in 29% of the patients, and 86% (12/14 biopsies) had an increase in intralesional CD8 T cells posttreatment. No partial responses by immune-related response criteria were seen, but evidence of abscopal effect was demonstrated following treatment with LTX-315. LTX-315 has an acceptable safety profile, is clinically active, induces changes in the tumor microenvironment and contributes to immune-mediated anticancer activity.
Published: 2021

46. Artificial intelligence for the differentiation between multiple sclerosis and glioma II° or III° using 18F-FET-PET imaging

Author: Rauschenbach, L, Kebir, S, Weber, M, Lazaridis, L, Schmidt, T, Keyvani, K, Schäfer, N, Umutlu, L, Pierscianek, D, Stuschke, M, Forsting, M, Sure, U, Kleinschnitz, C, Antoch, G, Colletti, P, Rubello, D, Herrmann, K, Herrlinger, U, Scheffler, B, Bundschuh, R, Glas, M, Rauschenbach, L, Kebir, S, Weber, M, Lazaridis, L, Schmidt, T, Keyvani, K, Schäfer, N, Umutlu, L, Pierscianek, D, Stuschke, M, Forsting, M, Sure, U, Kleinschnitz, C, Antoch, G, Colletti, P, Rubello, D, Herrmann, K, Herrlinger, U, Scheffler, B, Bundschuh, R, and Glas, M
Published: 2021

47. Large-scale migration into Britain during the Middle to Late Bronze Age

Author: Patterson, Nick, Isakov, Michael, Booth, Thomas, Büster, Lindsey, Fischer, Claire-Elise, Olalde, Iñigo, Ringbauer, Harald, Akbari, Ali, Cheronet, Olivia, Bleasdale, Madeleine, Adamski, Nicole, Altena, Eveline, Bernardos, Rebecca, Brace, Selina, Broomandkhoshbacht, Nasreen, Callan, Kimberly, Candilio, Francesca, Culleton, Brendan, Curtis, Elizabeth, Demetz, Lea, Carlson, Kellie Sara Duffett, Edwards, Ceiridwen J., Fernandes, Daniel M., Foody, M. George B., Freilich, Suzanne, Goodchild, Helen, Kearns, Aisling, Lawson, Ann Marie, Lazaridis, Iosif, Mah, Matthew, Mallick, Swapan, Mandl, Kirsten, Micco, Adam, Michel, Megan, Morante, Guillermo Bravo, Oppenheimer, Jonas, Özdoğan, Kadir Toykan, Qiu, Lijun, Schattke, Constanze, Stewardson, Kristin, Workman, J. Noah, Zalzala, Fatma, Zhang, Zhao, Agustí, Bibiana, Allen, Tim, Almássy, Katalin, Amkreutz, Luc, Ash, Abigail, Baillif-Ducros, Christèle, Barclay, Alistair, Patterson, Nick, Isakov, Michael, Booth, Thomas, Büster, Lindsey, Fischer, Claire-Elise, Olalde, Iñigo, Ringbauer, Harald, Akbari, Ali, Cheronet, Olivia, Bleasdale, Madeleine, Adamski, Nicole, Altena, Eveline, Bernardos, Rebecca, Brace, Selina, Broomandkhoshbacht, Nasreen, Callan, Kimberly, Candilio, Francesca, Culleton, Brendan, Curtis, Elizabeth, Demetz, Lea, Carlson, Kellie Sara Duffett, Edwards, Ceiridwen J., Fernandes, Daniel M., Foody, M. George B., Freilich, Suzanne, Goodchild, Helen, Kearns, Aisling, Lawson, Ann Marie, Lazaridis, Iosif, Mah, Matthew, Mallick, Swapan, Mandl, Kirsten, Micco, Adam, Michel, Megan, Morante, Guillermo Bravo, Oppenheimer, Jonas, Özdoğan, Kadir Toykan, Qiu, Lijun, Schattke, Constanze, Stewardson, Kristin, Workman, J. Noah, Zalzala, Fatma, Zhang, Zhao, Agustí, Bibiana, Allen, Tim, Almássy, Katalin, Amkreutz, Luc, Ash, Abigail, Baillif-Ducros, Christèle, and Barclay, Alistair
Published: 2021
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48. The intention for a preference : Aimless venture

Author: Lazaridis, Georgios and Lazaridis, Georgios
Abstract: In search of, the current and urgent, accompanied with our guiltless but potentially not agencies, we fight for the intelligence of reality. A zeitgeist that we try to ghostbust, that we hope to understand. A pandemonium circulated around the event, the now, the branches of time that flicker the possibilities and variations of expressions, that we as trajectories might solidify into a reality. "So, one can start from a simple question, at which one does not care to conclude with an answer: "why do we mark/trace a surface? Or for that matter, sculpt, think, animate etc." What is the inclination behind it? And more importantly, why do we cling to a specific preference?" In this essay I attempt a brief brush through from a number of familiar questions about art. And attempt to provide my own understanding, of art, creativity, society, and the ever newer intentions of the human expressive trajectories, that provide variations of possibilities and potentialities.
Published: 2021

49. Complete representation of action space and value in all dorsal striatal pathways

Author: Weglage, Moritz, Wärnberg, Emil, Lazaridis, Iakovos, Calvigioni, Daniela, Tzortzi, Ourania, Meletis, Konstantinos, Weglage, Moritz, Wärnberg, Emil, Lazaridis, Iakovos, Calvigioni, Daniela, Tzortzi, Ourania, and Meletis, Konstantinos
Abstract: The dorsal striatum plays a central role in the selection, execution, and evaluation of actions. An emerging model attributes action selection to the matrix and evaluation to the striosome compartment. Here, we use large-scale cell-type-specific calcium imaging to determine the activity of striatal projection neurons (SPNs) during motor and decision behaviors in the three major outputs of the dorsomedial striatum: Oprm1+ striosome versus D1+ direct and A2A+ indirect pathway SPNs. We find that Oprm1+ SPNs show complex tunings to simple movements and value-guided actions, which are conserved across many sessions in a single task but remap between contexts. During decision making, the SPN tuning profiles form a complete representation in which sequential SPN activity jointly encodes task progress and value. We propose that the three major output pathways in the dorsomedial striatum share a similarly complete representation of the entire action space, including task- and phase-specific signals of action value and choice., QC 20231101
Published: 2021
Full Text: View/download PDF

50. Complete representation of action space and value in all dorsal striatal pathways

Author: Weglage, Moritz, Wärnberg, Emil, Lazaridis, Iakovos, Calvigioni, Daniela, Tzortzi, Ourania, Meletis, Konstantinos, Weglage, Moritz, Wärnberg, Emil, Lazaridis, Iakovos, Calvigioni, Daniela, Tzortzi, Ourania, and Meletis, Konstantinos
Abstract: The dorsal striatum plays a central role in the selection, execution, and evaluation of actions. An emerging model attributes action selection to the matrix and evaluation to the striosome compartment. Here, we use large-scale cell-type-specific calcium imaging to determine the activity of striatal projection neurons (SPNs) during motor and decision behaviors in the three major outputs of the dorsomedial striatum: Oprm1+ striosome versus D1+ direct and A2A+ indirect pathway SPNs. We find that Oprm1+ SPNs show complex tunings to simple movements and value-guided actions, which are conserved across many sessions in a single task but remap between contexts. During decision making, the SPN tuning profiles form a complete representation in which sequential SPN activity jointly encodes task progress and value. We propose that the three major output pathways in the dorsomedial striatum share a similarly complete representation of the entire action space, including task- and phase-specific signals of action value and choice., QC 20231101
Published: 2021
Full Text: View/download PDF

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