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Introduction: Individual case reports are the main asset in pharmacovigilance signal management. Signal validation is the first stage after signal detection and aims to determine if there is sufficient evidence to justify further assessment. Throughout signal management, a prioritization of signals is continually made. Routinely collected health data can provide relevant contextual information but are primarily used at a later stage in pharmacoepidemiological studies to assess communicated signals. Objective: The aim of this study was to examine the feasibility and utility of analysing routine health data from a multinational distributed network to support signal validation and prioritization and to reflect on key user requirements for these analyses to become an integral part of this process. Methods: Statistical signal detection was performed in VigiBase, the WHO global database of individual case safety reports, targeting generic manufacturer drugs and 16 prespecified adverse events. During a 5-day study-a-thon, signal validation and prioritization were performed using information from VigiBase, regulatory documents and the scientific literature alongside descriptive analyses of routine health data from 10 partners of the European Health Data and Evidence Network (EHDEN). Databases included in the study were from the UK, Spain, Norway, the Netherlands and Serbia, capturing records from primary care and/or hospitals. Results: Ninety-five statistical signals were subjected to signal validation, of which eight were considered for descriptive analyses in the routine health data. Design, execution and interpretation of results from these analyses took up to a few hours for each signal (of which 15–60 minutes were for execution) and informed decisions for five out of eight signals. The impact of insights from the routine health data varied and included possible alternative explanations, potential public health and clinical impact and feasibility of follow-up pharmacoep

Неједнакости Коши-Шварца и Грис-Ландауа за елементарне операторе и трансформере типа унутрашњег производа на Q и Q∗ идеалима компактних оператора Резиме: Листа од раније познатих и недавно установљених Cauchy-Schwarz-ових неједнакости за елементарне операторе, σ−елементарне трансформере и трансформере типа унутрашњег производа допуњена је следећом варијантом Cauchy-Schwarz-ове неједнакости у Schatten-von Neumann-овим идеалима: ZΩ AtA∗ t dµ(t) 12q − 1Z2 Ω AtXBt dµ(t)ZΩ Bt∗Bt dµ(t) 1 2r − 12 p 6 ZΩ A∗ t At dµ(t) 12q XZΩ BtBt∗ dµ(t) 1 2r p за све X 2 C p(H) и све p, q, r > 1 такве да је 2 p = 1q + 1r, уколико су фамилије оператора fAtgt∈Ω, fA∗ tgt∈Ω, fBtgt∈Ω, fBt∗gt∈Ω јако квадратно интеграбилне, такве да су RΩ AtA∗ t dµ(t) и RΩ Bt∗Bt dµ(t) (ограничено) инвертибилни оператори. Разматраће се такође и друге варијанте оваквих неједнакости, омогућене додатним условима комутативности и нормалности операторних фамилија fAng∞ n=1, fBng∞ n=1, fAtgt∈Ω и fBtgt∈Ω, односно степеном p-модификације унитарно инваријантних норми, као и примене ових неједнакости на одређене проблеме у теорији оператора, укључујући норма неједнакости за генерализоване функцијске деривације Pick-ових оператор вредносних функција и оператор вредносних Fourier-ових трансформација комплексних мера, као и неједнакости Grüss-Landau-овог типа., List of already known and recently established Cauchy-Schwarz inequalities for elementary operators, σ−elementary transformers and inner product type transformers is complemented by the next variant of Cauchy-Schwarz inequality in Schatten-von Neumann ideals: ZΩ AtA∗ t dµ(t) 12q − 1Z2 Ω AtXBt dµ(t)ZΩ Bt∗Bt dµ(t) 1 2r − 12 p 6 ZΩ A∗ t At dµ(t) 12q XZΩ BtBt∗ dµ(t) 1 2r p for all X 2 C p(H) and for all p, q, r > 1 which satisfes 2 p = 1q + 1r, if families of operators fAtgt∈Ω, fA∗ tgt∈Ω, fBtgt∈Ω, fBt∗gt∈Ω are strongly square integrabile, such that RΩ AtA∗ t dµ(t) and RΩ Bt∗Bt dµ(t) are (boundedly) invertible operators. Enabled by some additional conditions of commutativity and normality for operator families fAng∞ n=1, fBng∞ n=1, fAtgt∈Ω and fBtgt∈Ω, as well as by the degree of p-modifcations of unitary invariant norms, some others variants of those inequalities will also be considered, including their applications to the certain problems in operator theory, norm inequalities for generalized function derivations of Pick operator values functions and operator values Fourier transformations of complex measures, as well as some Grüss-Landau type inequalities.

V želji po trajnostnem razvoju si v industrijskih podjetjih prizadevajo dosegati zelo lahke konstrukcije proizvoda s kar najmanjšim vplivom na okolje. Dober primer so pralni stroji, pri katerih je obvladovanje vibracij in hrupa kot stranski in neželeni učinek zelo pomembna naloga pri razvoju konkurenčnega proizvoda. Zato se tudi v industriji bele tehnike uporabljajo dognanja s področja adaptronike in adaptronskih sistemov, ki so sicer večinoma domena avtomobilske in letalske industrije. Prispevek prikazuje praktičen primer uporabe magnetnoreoloških dušilcev za analizo in razvoj dinamike pralnega stroja pri doseganju želenih funkcionalnih lastnosti. V dinamiki sistemov je tak tehnični sistem dušenja poznan kot sistem delno aktivnega ali adaptivnega obvladovanja (kontrole) vibracij. Opisane so tudi možnosti uporabnosti adaptronskih sistemov pri drugih elementih in komponentah pralnega stroja.

The paper presents a new algorithms of fractional process control - type which may include iterative learning feedback control (ILC). When the structure of object is not known or when many parameters cannot be determined, iterative learning control may be considered, [1]. Motivated by human learning, the basic idea of iterative learning control is to use information from previous execution of a trial in order to improve performance from trial to trial. This is an advantage, when accurate model of the system is not available as friction and actuator dynamics, though present in the system, are not modeled to reduce the computational complexity. Therefore, iterative learning control requires less a priori knowledge about the controlled system in the controller design phase and also less computational effort than many other kinds of control. ILC is a technique to control systems operating in a repetitive mode with the additional requirement that a specified output trajectory in an interval be followed to a high precision and in order to improve performance from trial to trial in the sense that the tracking error is sequentially reduced. Also, the fractional integro-differential operators-(fractional calculus) is a generalization of integration and derivation to non-integer order (fractional) operators and they provide an excellent instrument for the description of memory and hereditary properties of various materials and processes and, also obtaining more degrees of freedom in the model, [2]. Fractional order controllers can significantly improve static and dynamic control system properties and they are less sensitive to controlled systems and controllers parameters variations and can be used as robust controllers. In this paper different aspects of including the design schemes and control algorithms are covered. The control scheme comprises two types of control laws: a feedback law and a feed-forward control law where the controller provides stability of the system and