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1. The international EAACI/GA²LEN/EuroGuiDerm/APAAACI guideline for the definition, classification, diagnosis, and management of urticaria

Author: Zuberbier, Torsten, Abdul Latiff, Amir Hamzah, Abuzakouk, Mohamed, Aquilina, Susan, Asero, Riccardo, Baker, Diane, Ballmer-Weber, Barbara, Bangert, Christine, Ben-Shoshan, Moshe, Bernstein, Jonathan A., Bindslev-Jensen, Carsten, Brockow, Knut, Brzoza, Zenon, Chong Neto, Herberto Jose, Church, Martin K., Criado, Paulo R., Danilycheva, Inna V., Dressler, Corinna, Ensina, Luis Felipe, Fonacier, Luz, Gaskins, Matthew, Gáspár, Krisztian, Gelincik, Aslı, Giménez-Arnau, Ana, Godse, Kiran, Gonçalo, Margarida, Grattan, Clive, Grosber, Martine, Hamelmann, Eckard, Hébert, Jacques, Hide, Michihiro, Kaplan, Allen, Kapp, Alexander, Kessel, Aharon, Kocatürk, Emek, Kulthanan, Kanokvalai, Larenas-Linnemann, Désirée, Lauerma, Antti, Leslie, Tabi A., Magerl, Markus, Makris, Michael, Meshkova, Raisa Y., Metz, Martin, Micallef, Daniel, Mortz, Charlotte G., Nast, Alexander, Oude-Elberink, Hanneke, Pawankar, Ruby, Pigatto, Paolo D., Ratti Sisa, Hector, Rojo Gutiérrez, María Isabel, Saini, Sarbjit S., Schmid-Grendelmeier, Peter, Sekerel, Bulent E., Siebenhaar, Frank, Siiskonen, Hanna, Soria, Angele, Staubach-Renz, Petra, Stingeni, Luca, Sussman, Gordon, Szegedi, Andrea, Thomsen, Simon Francis, Vadasz, Zahava, Vestergaard, Christian, Wedi, Bettina, Zhao, Zuotao, Maurer, Marcus, Zuberbier, Torsten, Abdul Latiff, Amir Hamzah, Abuzakouk, Mohamed, Aquilina, Susan, Asero, Riccardo, Baker, Diane, Ballmer-Weber, Barbara, Bangert, Christine, Ben-Shoshan, Moshe, Bernstein, Jonathan A., Bindslev-Jensen, Carsten, Brockow, Knut, Brzoza, Zenon, Chong Neto, Herberto Jose, Church, Martin K., Criado, Paulo R., Danilycheva, Inna V., Dressler, Corinna, Ensina, Luis Felipe, Fonacier, Luz, Gaskins, Matthew, Gáspár, Krisztian, Gelincik, Aslı, Giménez-Arnau, Ana, Godse, Kiran, Gonçalo, Margarida, Grattan, Clive, Grosber, Martine, Hamelmann, Eckard, Hébert, Jacques, Hide, Michihiro, Kaplan, Allen, Kapp, Alexander, Kessel, Aharon, Kocatürk, Emek, Kulthanan, Kanokvalai, Larenas-Linnemann, Désirée, Lauerma, Antti, Leslie, Tabi A., Magerl, Markus, Makris, Michael, Meshkova, Raisa Y., Metz, Martin, Micallef, Daniel, Mortz, Charlotte G., Nast, Alexander, Oude-Elberink, Hanneke, Pawankar, Ruby, Pigatto, Paolo D., Ratti Sisa, Hector, Rojo Gutiérrez, María Isabel, Saini, Sarbjit S., Schmid-Grendelmeier, Peter, Sekerel, Bulent E., Siebenhaar, Frank, Siiskonen, Hanna, Soria, Angele, Staubach-Renz, Petra, Stingeni, Luca, Sussman, Gordon, Szegedi, Andrea, Thomsen, Simon Francis, Vadasz, Zahava, Vestergaard, Christian, Wedi, Bettina, Zhao, Zuotao, and Maurer, Marcus
Abstract: This update and revision of the international guideline for urticaria was developed following the methods recommended by Cochrane and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group. It is a joint initiative of the Dermatology Section of the European Academy of Allergology and Clinical Immunology (EAACI), the Global Allergy and Asthma European Network (GA²LEN) and its Urticaria and Angioedema Centers of Reference and Excellence (UCAREs and ACAREs), the European Dermatology Forum (EDF; EuroGuiDerm), and the Asia Pacific Association of Allergy, Asthma and Clinical Immunology with the participation of 64 delegates of 50 national and international societies and from 31 countries. The consensus conference was held on 3 December 2020. This guideline was acknowledged and accepted by the European Union of Medical Specialists (UEMS). Urticaria is a frequent, mast cell–driven disease that presents with wheals, angioedema, or both. The lifetime prevalence for acute urticaria is approximately 20%. Chronic spontaneous or inducible urticaria is disabling, impairs quality of life, and affects performance at work and school. This updated version of the international guideline for urticaria covers the definition and classification of urticaria and outlines expert-guided and evidence-based diagnostic and therapeutic approaches for the different subtypes of urticaria.
Published: 2022

2. The international EAACI/GA²LEN/EuroGuiDerm/APAAACI guideline for the definition, classification, diagnosis, and management of urticaria

Author: Zuberbier, Torsten, Abdul Latiff, Amir Hamzah, Abuzakouk, Mohamed, Aquilina, Susan, Asero, Riccardo, Baker, Diane, Ballmer-Weber, Barbara, Bangert, Christine, Ben-Shoshan, Moshe, Bernstein, Jonathan A., Bindslev-Jensen, Carsten, Brockow, Knut, Brzoza, Zenon, Chong Neto, Herberto Jose, Church, Martin K., Criado, Paulo R., Danilycheva, Inna V., Dressler, Corinna, Ensina, Luis Felipe, Fonacier, Luz, Gaskins, Matthew, Gáspár, Krisztian, Gelincik, Aslı, Giménez-Arnau, Ana, Godse, Kiran, Gonçalo, Margarida, Grattan, Clive, Grosber, Martine, Hamelmann, Eckard, Hébert, Jacques, Hide, Michihiro, Kaplan, Allen, Kapp, Alexander, Kessel, Aharon, Kocatürk, Emek, Kulthanan, Kanokvalai, Larenas-Linnemann, Désirée, Lauerma, Antti, Leslie, Tabi A., Magerl, Markus, Makris, Michael, Meshkova, Raisa Y., Metz, Martin, Micallef, Daniel, Mortz, Charlotte G., Nast, Alexander, Oude-Elberink, Hanneke, Pawankar, Ruby, Pigatto, Paolo D., Ratti Sisa, Hector, Rojo Gutiérrez, María Isabel, Saini, Sarbjit S., Schmid-Grendelmeier, Peter, Sekerel, Bulent E., Siebenhaar, Frank, Siiskonen, Hanna, Soria, Angele, Staubach-Renz, Petra, Stingeni, Luca, Sussman, Gordon, Szegedi, Andrea, Thomsen, Simon Francis, Vadasz, Zahava, Vestergaard, Christian, Wedi, Bettina, Zhao, Zuotao, Maurer, Marcus, Zuberbier, Torsten, Abdul Latiff, Amir Hamzah, Abuzakouk, Mohamed, Aquilina, Susan, Asero, Riccardo, Baker, Diane, Ballmer-Weber, Barbara, Bangert, Christine, Ben-Shoshan, Moshe, Bernstein, Jonathan A., Bindslev-Jensen, Carsten, Brockow, Knut, Brzoza, Zenon, Chong Neto, Herberto Jose, Church, Martin K., Criado, Paulo R., Danilycheva, Inna V., Dressler, Corinna, Ensina, Luis Felipe, Fonacier, Luz, Gaskins, Matthew, Gáspár, Krisztian, Gelincik, Aslı, Giménez-Arnau, Ana, Godse, Kiran, Gonçalo, Margarida, Grattan, Clive, Grosber, Martine, Hamelmann, Eckard, Hébert, Jacques, Hide, Michihiro, Kaplan, Allen, Kapp, Alexander, Kessel, Aharon, Kocatürk, Emek, Kulthanan, Kanokvalai, Larenas-Linnemann, Désirée, Lauerma, Antti, Leslie, Tabi A., Magerl, Markus, Makris, Michael, Meshkova, Raisa Y., Metz, Martin, Micallef, Daniel, Mortz, Charlotte G., Nast, Alexander, Oude-Elberink, Hanneke, Pawankar, Ruby, Pigatto, Paolo D., Ratti Sisa, Hector, Rojo Gutiérrez, María Isabel, Saini, Sarbjit S., Schmid-Grendelmeier, Peter, Sekerel, Bulent E., Siebenhaar, Frank, Siiskonen, Hanna, Soria, Angele, Staubach-Renz, Petra, Stingeni, Luca, Sussman, Gordon, Szegedi, Andrea, Thomsen, Simon Francis, Vadasz, Zahava, Vestergaard, Christian, Wedi, Bettina, Zhao, Zuotao, and Maurer, Marcus
Abstract: This update and revision of the international guideline for urticaria was developed following the methods recommended by Cochrane and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group. It is a joint initiative of the Dermatology Section of the European Academy of Allergology and Clinical Immunology (EAACI), the Global Allergy and Asthma European Network (GA²LEN) and its Urticaria and Angioedema Centers of Reference and Excellence (UCAREs and ACAREs), the European Dermatology Forum (EDF; EuroGuiDerm), and the Asia Pacific Association of Allergy, Asthma and Clinical Immunology with the participation of 64 delegates of 50 national and international societies and from 31 countries. The consensus conference was held on 3 December 2020. This guideline was acknowledged and accepted by the European Union of Medical Specialists (UEMS). Urticaria is a frequent, mast cell–driven disease that presents with wheals, angioedema, or both. The lifetime prevalence for acute urticaria is approximately 20%. Chronic spontaneous or inducible urticaria is disabling, impairs quality of life, and affects performance at work and school. This updated version of the international guideline for urticaria covers the definition and classification of urticaria and outlines expert-guided and evidence-based diagnostic and therapeutic approaches for the different subtypes of urticaria.
Published: 2022

3. Management of anaphylaxis due to COVID-19 vaccines in the elderly

Author: CTI Research, MS Dermatologie/Allergologie, Infection & Immunity, Bousquet, Jean, Agache, Ioana, Blain, Hubert, Jutel, Marek, Ventura, Maria Teresa, Worm, Margitta, Del Giacco, Stefano, Benetos, Athanasios, Bilo, Beatrice Maria, Czarlewski, Wienczyslawa, Abdul Latiff, Amir Hamzah, Al-Ahmad, Mona, Angier, Elizabeth, Annesi-Maesano, Isabella, Atanaskovic-Markovic, Marina, Bachert, Claus, Barbaud, Annick, Bedbrook, Anna, Bennoor, Kazi S., Berghea, Elena Camelia, Bindslev-Jensen, Carsten, Bonini, Sergio, Bosnic-Anticevich, Sinthia, Brockow, Knut, Brussino, Luisa, Camargos, Paulo, Canonica, G. Walter, Cardona, Victoria, Carreiro-Martins, Pedro, Carriazo, Ana, Casale, Thomas, Caubet, Jean Christoph, Cecchi, Lorenzo, Cherubini, Antonio, Christoff, George, Chu, Derek K., Cruz, Alvaro A., Dokic, Dejan, El-Gamal, Yehia, Ebisawa, Motohiro, Eberlein, Bernadette, Farrell, John, Fernandez-Rivas, Montserrat, Fokkens, Wytske J., Fonseca, Joao A., Gao, Yadong, Gavazzi, Gaëtan, Gawlik, Radoslaw, Gelincik, Asli, Gemicioğlu, Bilun, Gotua, Maia, Guérin, Olivier, Haahtela, Tari, Hoffmann-Sommergruber, Karin, Hoffmann, Hans Jürgen, Hofmann, Maja, Hrubisko, Martin, Illario, Maddalena, Irani, Carla, Ispayeva, Zhanat, Ivancevich, Juan Carlos, Julge, Kaja, Kaidashev, Igor, Khaitov, Musa, Knol, Edward, Kraxner, Helga, Kuna, Piotr, Kvedariene, Violeta, Lauerma, Antti, Le, Lan T.T., Le Moing, Vincent, Levin, Michael, Louis, Renaud, Lourenco, Olga, Mahler, Vera, Martin, Finbarr C., Matucci, Andrea, Milenkovic, Branislava, Miot, Stéphanie, Montella, Emma, Morais-Almeida, Mario, Mortz, Charlotte G., Mullol, Joaquim, Namazova-Baranova, Leyla, Neffen, Hugo, Nekam, Kristof, Niedoszytko, Marek, Odemyr, Mikaëla, O’Hehir, Robyn E., Okamoto, Yoshitaka, Ollert, Markus, Palomares, Oscar, Papadopoulos, Nikolaos G., Panzner, Petr, Passalacqua, Giovanni, Patella, Vincenzo, Petrovic, Mirko, Pfaar, Oliver, Pham-Thi, Nhân, Plavec, Davor, Popov, Todor A., Recto, Marysia T., Regateiro, Frederico S., Reynes, Jacques, Roller-Winsberger, Regina E., Rolland, Yves, Romano, Antonino, Rondon, Carmen, Rottem, Menachem, Rouadi, Philip W., Salles, Nathalie, Samolinski, Boleslaw, Santos, Alexandra F., S Sarquis, Faradiba, Sastre, Joaquin, M. G. A. Schols, Jos, Scichilone, Nicola, Sediva, Anna, Shamji, Mohamed H., Sheikh, Aziz, Skypala, Isabel, Smolinska, Sylwia, Sokolowska, Milena, Sousa-Pinto, Bernardo, Sova, Milan, Stelmach, Rafael, Sturm, Gunter, Suppli Ulrik, Charlotte, Todo-Bom, Ana Maria, Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Torres, Maria, Untersmayr, Eva, Urrutia Pereira, Marilyn, Valiulis, Arunas, Vitte, Joana, Vultaggio, Alessandra, Wallace, Dana, Walusiak-Skorupa, Jolanta, Wang, De Yun, Waserman, Susan, Yorgancioglu, Arzu, Yusuf, Osman M., Zernotti, Mario, Zidarn, Mihaela, Chivato, Tomas, Akdis, Cezmi A., Zuberbier, Torsten, Klimek, Ludger, CTI Research, MS Dermatologie/Allergologie, Infection & Immunity, Bousquet, Jean, Agache, Ioana, Blain, Hubert, Jutel, Marek, Ventura, Maria Teresa, Worm, Margitta, Del Giacco, Stefano, Benetos, Athanasios, Bilo, Beatrice Maria, Czarlewski, Wienczyslawa, Abdul Latiff, Amir Hamzah, Al-Ahmad, Mona, Angier, Elizabeth, Annesi-Maesano, Isabella, Atanaskovic-Markovic, Marina, Bachert, Claus, Barbaud, Annick, Bedbrook, Anna, Bennoor, Kazi S., Berghea, Elena Camelia, Bindslev-Jensen, Carsten, Bonini, Sergio, Bosnic-Anticevich, Sinthia, Brockow, Knut, Brussino, Luisa, Camargos, Paulo, Canonica, G. Walter, Cardona, Victoria, Carreiro-Martins, Pedro, Carriazo, Ana, Casale, Thomas, Caubet, Jean Christoph, Cecchi, Lorenzo, Cherubini, Antonio, Christoff, George, Chu, Derek K., Cruz, Alvaro A., Dokic, Dejan, El-Gamal, Yehia, Ebisawa, Motohiro, Eberlein, Bernadette, Farrell, John, Fernandez-Rivas, Montserrat, Fokkens, Wytske J., Fonseca, Joao A., Gao, Yadong, Gavazzi, Gaëtan, Gawlik, Radoslaw, Gelincik, Asli, Gemicioğlu, Bilun, Gotua, Maia, Guérin, Olivier, Haahtela, Tari, Hoffmann-Sommergruber, Karin, Hoffmann, Hans Jürgen, Hofmann, Maja, Hrubisko, Martin, Illario, Maddalena, Irani, Carla, Ispayeva, Zhanat, Ivancevich, Juan Carlos, Julge, Kaja, Kaidashev, Igor, Khaitov, Musa, Knol, Edward, Kraxner, Helga, Kuna, Piotr, Kvedariene, Violeta, Lauerma, Antti, Le, Lan T.T., Le Moing, Vincent, Levin, Michael, Louis, Renaud, Lourenco, Olga, Mahler, Vera, Martin, Finbarr C., Matucci, Andrea, Milenkovic, Branislava, Miot, Stéphanie, Montella, Emma, Morais-Almeida, Mario, Mortz, Charlotte G., Mullol, Joaquim, Namazova-Baranova, Leyla, Neffen, Hugo, Nekam, Kristof, Niedoszytko, Marek, Odemyr, Mikaëla, O’Hehir, Robyn E., Okamoto, Yoshitaka, Ollert, Markus, Palomares, Oscar, Papadopoulos, Nikolaos G., Panzner, Petr, Passalacqua, Giovanni, Patella, Vincenzo, Petrovic, Mirko, Pfaar, Oliver, Pham-Thi, Nhân, Plavec, Davor, Popov, Todor A., Recto, Marysia T., Regateiro, Frederico S., Reynes, Jacques, Roller-Winsberger, Regina E., Rolland, Yves, Romano, Antonino, Rondon, Carmen, Rottem, Menachem, Rouadi, Philip W., Salles, Nathalie, Samolinski, Boleslaw, Santos, Alexandra F., S Sarquis, Faradiba, Sastre, Joaquin, M. G. A. Schols, Jos, Scichilone, Nicola, Sediva, Anna, Shamji, Mohamed H., Sheikh, Aziz, Skypala, Isabel, Smolinska, Sylwia, Sokolowska, Milena, Sousa-Pinto, Bernardo, Sova, Milan, Stelmach, Rafael, Sturm, Gunter, Suppli Ulrik, Charlotte, Todo-Bom, Ana Maria, Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Torres, Maria, Untersmayr, Eva, Urrutia Pereira, Marilyn, Valiulis, Arunas, Vitte, Joana, Vultaggio, Alessandra, Wallace, Dana, Walusiak-Skorupa, Jolanta, Wang, De Yun, Waserman, Susan, Yorgancioglu, Arzu, Yusuf, Osman M., Zernotti, Mario, Zidarn, Mihaela, Chivato, Tomas, Akdis, Cezmi A., Zuberbier, Torsten, and Klimek, Ludger
Published: 2021

4. ARIA‐EAACI care pathways for allergen immunotherapy in respiratory allergy

Author: Bousquet, Jean, Pfaar, Oliver, Agache, Ioana, Bedbrook, Anna, Akdis, Cezmi A, Canonica, G. Walter, Chivato, Tomas, Al‐ahmad, Mona, Abdul Latiff, Amir H, Ansotegui, Ignacio J, Bachert, Claus, Baharuddin, Abdullah, Bergmann, Karl‐christian, Bindslev‐jensen, Carsten, Bjermer, Leif, Bonini, Matteo, Bosnic‐anticevich, Sinthia, Bosse, Isabelle, Brough, Helen A., Brussino, Luisa, Calderon, Moises A, Caraballo, Luis, Cardona, Victoria, Carreiro‐martins, Pedro, Casale, Tomas, Cecchi, Lorenzo, Cepeda Sarabia, Alfonso M, Chkhartishvili, Ekaterine, Chu, Derek K, Cirule, Ieva, Cruz, Alvaro A, Czarlewski, Wienczyslawa, Giacco, Stefano, Demoly, Pascal, Devillier, Philippe, Dokic, Dejan, Durham, Stephen L, Ebisawa, Motohiro, El‐gamal✝, Yehia, Emuzyte, Regina, Gamkrelidze, Amiran, Fauquert, Jean Luc, Fiocchi, Alessandro, Fokkens, Wytske J, Fonseca, Joao A, Fontaine, Jean‐françois, Gawlik, Radoslaw, Gelincik, Asli, Gemicioglu, Bilun, Gereda, Jose E, Gerth Van Wijk, Roy, Gomez, R Maximiliano, Gotua, Maia, Grisle, Ineta, Guzmán, Maria‐antonieta, Haahtela, Tari, Halken, Susanne, Heffler, Enrico, Hoffmann‐sommergruber, Karin, Hossny, Elham, Hrubiško, Martin, Irani, Carla, Ivancevich, Juan Carlos, Ispayeva, Zhanat, Julge, Kaja, Kaidashev, Igor, Kalayci, Omer, Khaitov, Musa, Klimek, Ludger, Knol, Edward, Kowalski, Marek L, Kraxner, Helga, Kull, Inger, Kuna, Piotr, Kvedariene, Violeta, Kritikos, Vicky, Lauerma, Antti, Lau, Susanne, Laune, Daniel, Levin, Michael, Larenas‐linnemann, Desiree E, Lodrup Carlsen, Karin C, Lombardi, Carlo, Lourenço, Olga M, Mahboub, Bassam, Malling, Hans‐jørgen, Manning, Patrick, Marshall, Gailen D, Melén, Erik, Meltzer, Eli O, Miculinic, Neven, Milenkovic, Branislava, Moin, Mostafa, Montefort, Stephen, Morais‐almeida, Mario, Mortz, Charlotte G, Mösges, Ralph, Mullol, Joaquim, Namazova Baranova, Leyla, Neffen, Hugo, Nekam, Kristof, Niedoszytko, Marek, Odemyr, Mikaëla, O'hehir, Robyn E, Ollert, Markus, O'mahony, Liam, Ohta, Ken, Okamoto, Yoshitaka, Okubo, Kimi, Pajno, Giovanni B, Palomares, Oscar, Palkonen, Susanna, Panzner, Petr, Papadopoulos, Nikolaos, Park, Hae‐sim, Passalacqua, Giovanni, Patella, Vincenzo, Pawankar, Ruby, Pham‐thi, Nhân, Plavec, Davor, Popov, Todor A, Recto, Marysia, Regateiro, Frederico S, Riggioni, Carmen, Roberts, Graham, Rodriguez‐gonzales, Monica, Rosario, Nelson, Rottem, Menachem, Rouadi, Philip W, Ryan, Dermot, Samolinski, Boleslaw, Sanchez‐borges✝, Mario, Serpa, Faradiba S, Sastre, Joaquin, Scadding, Glenis K., Shamji, Mohamed H, Schmid‐grendelmeier, Peter, Schünemann, Holger J, Sheikh, Aziz, Scichilone, Nicola, Sisul, Juan Carlos, Sofiev, Mikhail, Solé, Dirceu, Sooronbaev, Talant, Soto‐martinez, Manuel, Soto‐quiros, Manuel, Sova, Milan, Schwarze, Jürgen, Skypala, Isabel, Suppli‐ulrik, Charlotte, Taborda‐barata, Luis, Todo‐bom, Ana, Torres, Maria J, Valentin‐rostan, Marylin, Tomazic, Peter‐valentin, Valero, Antonio, Toppila‐salmi, Sanna, Tsiligianni, Ioanna, Untersmayr, Eva, Urrutia‐pereira, Marilyn, Valiulis, Arunas, Valovirta, Erkka, Vandenplas, Olivier, Ventura, Maria Teresa, Vichyanond, Pakit, Wagenmann, Martin, Wallace, Dana, Walusiak‐skorupa, Jolanta, Wang, De Yun, Waserman, Susan, Wong, Gary Wk, Yorgancioglu, Arzu, Yusuf, Osman M, Zernotti, Mario, Zhang, Luo, Zidarn, Mihaela, Zuberbier, Torsten, Jutel, Marek, Bousquet, Jean, Pfaar, Oliver, Agache, Ioana, Bedbrook, Anna, Akdis, Cezmi A, Canonica, G. Walter, Chivato, Tomas, Al‐ahmad, Mona, Abdul Latiff, Amir H, Ansotegui, Ignacio J, Bachert, Claus, Baharuddin, Abdullah, Bergmann, Karl‐christian, Bindslev‐jensen, Carsten, Bjermer, Leif, Bonini, Matteo, Bosnic‐anticevich, Sinthia, Bosse, Isabelle, Brough, Helen A., Brussino, Luisa, Calderon, Moises A, Caraballo, Luis, Cardona, Victoria, Carreiro‐martins, Pedro, Casale, Tomas, Cecchi, Lorenzo, Cepeda Sarabia, Alfonso M, Chkhartishvili, Ekaterine, Chu, Derek K, Cirule, Ieva, Cruz, Alvaro A, Czarlewski, Wienczyslawa, Giacco, Stefano, Demoly, Pascal, Devillier, Philippe, Dokic, Dejan, Durham, Stephen L, Ebisawa, Motohiro, El‐gamal✝, Yehia, Emuzyte, Regina, Gamkrelidze, Amiran, Fauquert, Jean Luc, Fiocchi, Alessandro, Fokkens, Wytske J, Fonseca, Joao A, Fontaine, Jean‐françois, Gawlik, Radoslaw, Gelincik, Asli, Gemicioglu, Bilun, Gereda, Jose E, Gerth Van Wijk, Roy, Gomez, R Maximiliano, Gotua, Maia, Grisle, Ineta, Guzmán, Maria‐antonieta, Haahtela, Tari, Halken, Susanne, Heffler, Enrico, Hoffmann‐sommergruber, Karin, Hossny, Elham, Hrubiško, Martin, Irani, Carla, Ivancevich, Juan Carlos, Ispayeva, Zhanat, Julge, Kaja, Kaidashev, Igor, Kalayci, Omer, Khaitov, Musa, Klimek, Ludger, Knol, Edward, Kowalski, Marek L, Kraxner, Helga, Kull, Inger, Kuna, Piotr, Kvedariene, Violeta, Kritikos, Vicky, Lauerma, Antti, Lau, Susanne, Laune, Daniel, Levin, Michael, Larenas‐linnemann, Desiree E, Lodrup Carlsen, Karin C, Lombardi, Carlo, Lourenço, Olga M, Mahboub, Bassam, Malling, Hans‐jørgen, Manning, Patrick, Marshall, Gailen D, Melén, Erik, Meltzer, Eli O, Miculinic, Neven, Milenkovic, Branislava, Moin, Mostafa, Montefort, Stephen, Morais‐almeida, Mario, Mortz, Charlotte G, Mösges, Ralph, Mullol, Joaquim, Namazova Baranova, Leyla, Neffen, Hugo, Nekam, Kristof, Niedoszytko, Marek, Odemyr, Mikaëla, O'hehir, Robyn E, Ollert, Markus, O'mahony, Liam, Ohta, Ken, Okamoto, Yoshitaka, Okubo, Kimi, Pajno, Giovanni B, Palomares, Oscar, Palkonen, Susanna, Panzner, Petr, Papadopoulos, Nikolaos, Park, Hae‐sim, Passalacqua, Giovanni, Patella, Vincenzo, Pawankar, Ruby, Pham‐thi, Nhân, Plavec, Davor, Popov, Todor A, Recto, Marysia, Regateiro, Frederico S, Riggioni, Carmen, Roberts, Graham, Rodriguez‐gonzales, Monica, Rosario, Nelson, Rottem, Menachem, Rouadi, Philip W, Ryan, Dermot, Samolinski, Boleslaw, Sanchez‐borges✝, Mario, Serpa, Faradiba S, Sastre, Joaquin, Scadding, Glenis K., Shamji, Mohamed H, Schmid‐grendelmeier, Peter, Schünemann, Holger J, Sheikh, Aziz, Scichilone, Nicola, Sisul, Juan Carlos, Sofiev, Mikhail, Solé, Dirceu, Sooronbaev, Talant, Soto‐martinez, Manuel, Soto‐quiros, Manuel, Sova, Milan, Schwarze, Jürgen, Skypala, Isabel, Suppli‐ulrik, Charlotte, Taborda‐barata, Luis, Todo‐bom, Ana, Torres, Maria J, Valentin‐rostan, Marylin, Tomazic, Peter‐valentin, Valero, Antonio, Toppila‐salmi, Sanna, Tsiligianni, Ioanna, Untersmayr, Eva, Urrutia‐pereira, Marilyn, Valiulis, Arunas, Valovirta, Erkka, Vandenplas, Olivier, Ventura, Maria Teresa, Vichyanond, Pakit, Wagenmann, Martin, Wallace, Dana, Walusiak‐skorupa, Jolanta, Wang, De Yun, Waserman, Susan, Wong, Gary Wk, Yorgancioglu, Arzu, Yusuf, Osman M, Zernotti, Mario, Zhang, Luo, Zidarn, Mihaela, Zuberbier, Torsten, and Jutel, Marek
Published: 2021

5. COVID-19 pandemic: Practical considerations on the organization of an allergy clinic-An EAACI/ARIA Position Paper.

Author: UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (SLuc) Service d'oto-rhino-laryngologie, Pfaar, Oliver, Klimek, Ludger, Jutel, Marek, Akdis, Cezmi A, Bousquet, Jean, Breiteneder, Heimo, Chinthrajah, Sharon, Diamant, Zuzana, Eiwegger, Thomas, Fokkens, Wytske J, Fritsch, Hans-Walter, Nadeau, Kari C, O'Hehir, Robyn E, O'Mahony, Liam, Rief, Winfried, Sampath, Vanitha, Schedlowski, Manfred, Torres, María José, Traidl-Hoffmann, Claudia, Wang, De Yun, Zhang, Luo, Bonini, Matteo, Brehler, Randolf, Brough, Helen Annaruth, Chivato, Tomás, Del Giacco, Stefano R, Dramburg, Stephanie, Gawlik, Radoslaw, Gelincik, Aslı, Hoffmann-Sommergruber, Karin, Hox, Valérie, Knol, Edward F, Lauerma, Antti, Matricardi, Paolo M, Mortz, Charlotte G, Ollert, Markus, Palomares, Oscar, Riggioni, Carmen, Schwarze, Jürgen, Skypala, Isabel, Untersmayr, Eva, Walusiak-Skorupa, Jolanta, Ansotegui, Ignacio J, Bachert, Claus, Bedbrook, Anna, Bosnic-Anticevich, Sinthia, Brussino, Luisa, Canonica, Giorgio Walter, Cardona, Victoria, Carreiro-Martins, Pedro, Cruz, Alvaro A, Czarlewski, Wienczyslawa, Fonseca, João A, Gotua, Maia, Haahtela, Tari, Ivancevich, Juan Carlos, Kuna, Piotr, Kvedariene, Violeta, Larenas-Linnemann, Désirée Erlinda, Abdul Latiff, Amir Hamzah, Mäkelä, Mika, Morais-Almeida, Mário, Mullol, Joaquim, Naclerio, Robert, Ohta, Ken, Okamoto, Yoshitaka, Onorato, Gabrielle L, Papadopoulos, Nikolaos G, Patella, Vincenzo, Regateiro, Frederico S, Samoliński, Bolesław, Suppli Ulrik, Charlotte, Toppila-Salmi, Sanna, Valiulis, Arunas, Ventura, Maria-Teresa, Yorgancioglu, Arzu, Zuberbier, Torsten, Agache, Ioana, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (SLuc) Service d'oto-rhino-laryngologie, Pfaar, Oliver, Klimek, Ludger, Jutel, Marek, Akdis, Cezmi A, Bousquet, Jean, Breiteneder, Heimo, Chinthrajah, Sharon, Diamant, Zuzana, Eiwegger, Thomas, Fokkens, Wytske J, Fritsch, Hans-Walter, Nadeau, Kari C, O'Hehir, Robyn E, O'Mahony, Liam, Rief, Winfried, Sampath, Vanitha, Schedlowski, Manfred, Torres, María José, Traidl-Hoffmann, Claudia, Wang, De Yun, Zhang, Luo, Bonini, Matteo, Brehler, Randolf, Brough, Helen Annaruth, Chivato, Tomás, Del Giacco, Stefano R, Dramburg, Stephanie, Gawlik, Radoslaw, Gelincik, Aslı, Hoffmann-Sommergruber, Karin, Hox, Valérie, Knol, Edward F, Lauerma, Antti, Matricardi, Paolo M, Mortz, Charlotte G, Ollert, Markus, Palomares, Oscar, Riggioni, Carmen, Schwarze, Jürgen, Skypala, Isabel, Untersmayr, Eva, Walusiak-Skorupa, Jolanta, Ansotegui, Ignacio J, Bachert, Claus, Bedbrook, Anna, Bosnic-Anticevich, Sinthia, Brussino, Luisa, Canonica, Giorgio Walter, Cardona, Victoria, Carreiro-Martins, Pedro, Cruz, Alvaro A, Czarlewski, Wienczyslawa, Fonseca, João A, Gotua, Maia, Haahtela, Tari, Ivancevich, Juan Carlos, Kuna, Piotr, Kvedariene, Violeta, Larenas-Linnemann, Désirée Erlinda, Abdul Latiff, Amir Hamzah, Mäkelä, Mika, Morais-Almeida, Mário, Mullol, Joaquim, Naclerio, Robert, Ohta, Ken, Okamoto, Yoshitaka, Onorato, Gabrielle L, Papadopoulos, Nikolaos G, Patella, Vincenzo, Regateiro, Frederico S, Samoliński, Bolesław, Suppli Ulrik, Charlotte, Toppila-Salmi, Sanna, Valiulis, Arunas, Ventura, Maria-Teresa, Yorgancioglu, Arzu, Zuberbier, Torsten, and Agache, Ioana
Abstract: BACKGROUND: The coronavirus disease 2019 (COVID-19) has evolved into a pandemic infectious disease transmitted by the severe acute respiratory syndrome coronavirus (SARS-CoV-2). Allergists and other healthcare providers (HCPs) in the field of allergies and associated airway diseases are on the front line, taking care of patients potentially infected with SARS-CoV-2. Hence, strategies and practices to minimize risks of infection for both HCPs and treated patients have to be developed and followed by allergy clinics. METHOD: The scientific information on COVID-19 was analysed by a literature search in MEDLINE, PubMed, the National and International Guidelines from the European Academy of Allergy and Clinical Immunology (EAACI), the Cochrane Library, and the internet. RESULTS: Based on the diagnostic and treatment standards developed by EAACI, on international information regarding COVID-19, on guidelines of the World Health Organization (WHO) and other international organizations, and on previous experience, a panel of experts including clinicians, psychologists, IT experts, and basic scientists along with EAACI and the "Allergic Rhinitis and its Impact on Asthma (ARIA)" initiative have developed recommendations for the optimal management of allergy clinics during the current COVID-19 pandemic. These recommendations are grouped into nine sections on different relevant aspects for the care of patients with allergies. CONCLUSIONS: This international Position Paper provides recommendations on operational plans and procedures to maintain high standards in the daily clinical care of allergic patients while ensuring the necessary safety measures in the current COVID-19 pandemic.
Published: 2021

6. COVID-19 pandemic:Practical considerations on the organization of an allergy clinic—An EAACI/ARIA Position Paper

Author: Pfaar, Oliver, Klimek, Ludger, Jutel, Marek, Akdis, Cezmi A., Bousquet, Jean, Breiteneder, Heimo, Chinthrajah, Sharon, Diamant, Zuzana, Eiwegger, Thomas, Fokkens, Wytske J., Fritsch, Hans Walter, Nadeau, Kari C., O’Hehir, Robyn E., O’Mahony, Liam, Rief, Winfried, Sampath, Vanitha, Schedlowski, Manfred, Torres, María José, Traidl-Hoffmann, Claudia, Wang, De Yun, Zhang, Luo, Bonini, Matteo, Brehler, Randolf, Brough, Helen Annaruth, Chivato, Tomás, Del Giacco, Stefano R., Dramburg, Stephanie, Gawlik, Radoslaw, Gelincik, Aslı, Hoffmann-Sommergruber, Karin, Hox, Valerie, Knol, Edward F., Lauerma, Antti, Matricardi, Paolo M., Mortz, Charlotte G., Ollert, Markus, Palomares, Oscar, Riggioni, Carmen, Schwarze, Jürgen, Skypala, Isabel, Untersmayr, Eva, Walusiak-Skorupa, Jolanta, Ansotegui, Ignacio J., Bachert, Claus, Bedbrook, Anna, Bosnic-Anticevich, Sinthia, Brussino, Luisa, Canonica, Giorgio Walter, Cardona, Victoria, Carreiro-Martins, Pedro, Cruz, Alvaro A., Czarlewski, Wienczyslawa, Fonseca, João A., Gotua, Maia, Haahtela, Tari, Ivancevich, Juan Carlos, Kuna, Piotr, Kvedariene, Violeta, Larenas-Linnemann, Désirée Erlinda, Abdul Latiff, Amir Hamzah, Mäkelä, Mika, Morais-Almeida, Mário, Mullol, Joaquim, Naclerio, Robert, Ohta, Ken, Okamoto, Yoshitaka, Onorato, Gabrielle L., Papadopoulos, Nikolaos G., Patella, Vincenzo, Regateiro, Frederico S., Samoliński, Bolesław, Suppli Ulrik, Charlotte, Toppila-Salmi, Sanna, Valiulis, Arunas, Ventura, Maria Teresa, Yorgancioglu, Arzu, Zuberbier, Torsten, Agache, Ioana, Pfaar, Oliver, Klimek, Ludger, Jutel, Marek, Akdis, Cezmi A., Bousquet, Jean, Breiteneder, Heimo, Chinthrajah, Sharon, Diamant, Zuzana, Eiwegger, Thomas, Fokkens, Wytske J., Fritsch, Hans Walter, Nadeau, Kari C., O’Hehir, Robyn E., O’Mahony, Liam, Rief, Winfried, Sampath, Vanitha, Schedlowski, Manfred, Torres, María José, Traidl-Hoffmann, Claudia, Wang, De Yun, Zhang, Luo, Bonini, Matteo, Brehler, Randolf, Brough, Helen Annaruth, Chivato, Tomás, Del Giacco, Stefano R., Dramburg, Stephanie, Gawlik, Radoslaw, Gelincik, Aslı, Hoffmann-Sommergruber, Karin, Hox, Valerie, Knol, Edward F., Lauerma, Antti, Matricardi, Paolo M., Mortz, Charlotte G., Ollert, Markus, Palomares, Oscar, Riggioni, Carmen, Schwarze, Jürgen, Skypala, Isabel, Untersmayr, Eva, Walusiak-Skorupa, Jolanta, Ansotegui, Ignacio J., Bachert, Claus, Bedbrook, Anna, Bosnic-Anticevich, Sinthia, Brussino, Luisa, Canonica, Giorgio Walter, Cardona, Victoria, Carreiro-Martins, Pedro, Cruz, Alvaro A., Czarlewski, Wienczyslawa, Fonseca, João A., Gotua, Maia, Haahtela, Tari, Ivancevich, Juan Carlos, Kuna, Piotr, Kvedariene, Violeta, Larenas-Linnemann, Désirée Erlinda, Abdul Latiff, Amir Hamzah, Mäkelä, Mika, Morais-Almeida, Mário, Mullol, Joaquim, Naclerio, Robert, Ohta, Ken, Okamoto, Yoshitaka, Onorato, Gabrielle L., Papadopoulos, Nikolaos G., Patella, Vincenzo, Regateiro, Frederico S., Samoliński, Bolesław, Suppli Ulrik, Charlotte, Toppila-Salmi, Sanna, Valiulis, Arunas, Ventura, Maria Teresa, Yorgancioglu, Arzu, Zuberbier, Torsten, and Agache, Ioana
Abstract: Background: The coronavirus disease 2019 (COVID-19) has evolved into a pandemic infectious disease transmitted by the severe acute respiratory syndrome coronavirus (SARS-CoV-2). Allergists and other healthcare providers (HCPs) in the field of allergies and associated airway diseases are on the front line, taking care of patients potentially infected with SARS-CoV-2. Hence, strategies and practices to minimize risks of infection for both HCPs and treated patients have to be developed and followed by allergy clinics. Method: The scientific information on COVID-19 was analysed by a literature search in MEDLINE, PubMed, the National and International Guidelines from the European Academy of Allergy and Clinical Immunology (EAACI), the Cochrane Library, and the internet. Results: Based on the diagnostic and treatment standards developed by EAACI, on international information regarding COVID-19, on guidelines of the World Health Organization (WHO) and other international organizations, and on previous experience, a panel of experts including clinicians, psychologists, IT experts, and basic scientists along with EAACI and the “Allergic Rhinitis and its Impact on Asthma (ARIA)” initiative have developed recommendations for the optimal management of allergy clinics during the current COVID-19 pandemic. These recommendations are grouped into nine sections on different relevant aspects for the care of patients with allergies. Conclusions: This international Position Paper provides recommendations on operational plans and procedures to maintain high standards in the daily clinical care of allergic patients while ensuring the necessary safety measures in the current COVID-19 pandemic.
Published: 2021

7. The international EAACI/GA(2)LEN/EuroGuiDerm/APAAACI guideline for the definition, classification, diagnosis, and management of urticaria

Author: Göncü, Özgür Emek Kocatürk (ORCID 0000-0003-2801-0959 & YÖK ID 217219), Zuberbier, Torsten; Abdul Latiff, Amir Hamzah; Abuzakouk, Mohamed; Aquilina, Susan; Asero, Riccardo; Baker, Diane; Ballmer-Weber, Barbara; Bangert, Christine; Ben-Shoshan, Moshe; Bernstein, Jonathan A.; Bindslev-Jensen, Carsten; Brockow, Knut; Brzoza, Zenon; Chong Neto, Herberto Jose; Church, Martin K.; Criado, Paulo R.; Danilycheva, Inna V.; Dressler, Corinna; Ensina, Luis Felipe; Fonacier, Luz; Gaskins, Matthew; Gaspar, Krisztian; Gelincik, Asli; Gimenez-Arnau, Ana; Godse, Kiran; Goncalo, Margarida; Grattan, Clive; Grosber, Martine; Hamelmann, Eckard; Hebert, Jacques; Hide, Michihiro; Kaplan, Allen; Kapp, Alexander; Kessel, Aharon; Kulthanan, Kanokvalai; Larenas-Linnemann, Desiree; Lauerma, Antti; Leslie, Tabi A.; Magerl, Markus; Makris, Michael; Meshkova, Raisa Y.; Metz, Martin; Micallef, Daniel; Mortz, Charlotte G.; Nast, Alexander; Oude-Elberink, Hanneke; Pawankar, Ruby; Pigatto, Paolo D.; Ratti Sisa, Hector; Rojo Gutierrez, Maria Isabel; Saini, Sarbjit S.; Schmid-Grendelmeier, Peter; Sekerel, Bulent E.; Siebenhaar, Frank; Siiskonen, Hanna; Soria, Angele; Staubach-Renz, Petra; Stingeni, Luca; Sussman, Gordon; Szegedi, Andrea; Thomsen, Simon Francis; Vadasz, Zahava; Vestergaard, Christian; Wedi, Bettina; Zhao, Zuotao; Maurer, Marcus, School of Medicine, Göncü, Özgür Emek Kocatürk (ORCID 0000-0003-2801-0959 & YÖK ID 217219), Zuberbier, Torsten; Abdul Latiff, Amir Hamzah; Abuzakouk, Mohamed; Aquilina, Susan; Asero, Riccardo; Baker, Diane; Ballmer-Weber, Barbara; Bangert, Christine; Ben-Shoshan, Moshe; Bernstein, Jonathan A.; Bindslev-Jensen, Carsten; Brockow, Knut; Brzoza, Zenon; Chong Neto, Herberto Jose; Church, Martin K.; Criado, Paulo R.; Danilycheva, Inna V.; Dressler, Corinna; Ensina, Luis Felipe; Fonacier, Luz; Gaskins, Matthew; Gaspar, Krisztian; Gelincik, Asli; Gimenez-Arnau, Ana; Godse, Kiran; Goncalo, Margarida; Grattan, Clive; Grosber, Martine; Hamelmann, Eckard; Hebert, Jacques; Hide, Michihiro; Kaplan, Allen; Kapp, Alexander; Kessel, Aharon; Kulthanan, Kanokvalai; Larenas-Linnemann, Desiree; Lauerma, Antti; Leslie, Tabi A.; Magerl, Markus; Makris, Michael; Meshkova, Raisa Y.; Metz, Martin; Micallef, Daniel; Mortz, Charlotte G.; Nast, Alexander; Oude-Elberink, Hanneke; Pawankar, Ruby; Pigatto, Paolo D.; Ratti Sisa, Hector; Rojo Gutierrez, Maria Isabel; Saini, Sarbjit S.; Schmid-Grendelmeier, Peter; Sekerel, Bulent E.; Siebenhaar, Frank; Siiskonen, Hanna; Soria, Angele; Staubach-Renz, Petra; Stingeni, Luca; Sussman, Gordon; Szegedi, Andrea; Thomsen, Simon Francis; Vadasz, Zahava; Vestergaard, Christian; Wedi, Bettina; Zhao, Zuotao; Maurer, Marcus, and School of Medicine
Abstract: This update and revision of the international guideline for urticaria was developed following the methods recommended by Cochrane and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group. It is a joint initiative of the Dermatology Section of the European Academy of Allergology and Clinical Immunology (EAACI), the Global Allergy and Asthma European Network (GA(2)LEN) and its Urticaria and Angioedema Centers of Reference and Excellence (UCAREs and ACAREs), the European Dermatology Forum (EDF; EuroGuiDerm), and the Asia Pacific Association of Allergy, Asthma and Clinical Immunology with the participation of 64 delegates of 50 national and international societies and from 31 countries. The consensus conference was held on 3 December 2020. This guideline was acknowledged and accepted by the European Union of Medical Specialists (UEMS). Urticaria is a frequent, mast cell-driven disease that presents with wheals, angioedema, or both. The lifetime prevalence for acute urticaria is approximately 20%. Chronic spontaneous or inducible urticaria is disabling, impairs quality of life, and affects performance at work and school. This updated version of the international guideline for urticaria covers the definition and classification of urticaria and outlines expert-guided and evidence-based diagnostic and therapeutic approaches for the different subtypes of urticaria., Urticaria and Angioedema Centers of Reference and Excellence (UCAREs and ACAREs); European Union (EU); 6th Framework Programme; Global Allergy and Asthma European Network (GA2LEN); European Academy of Allergology and Clinical Immunology (EAACI); Asia Pacific Association of Allergy, Asthma and Clinical Immunology (APAAACI); European Dermatology Forum (EDF)
Published: 2021

8. Management of anaphylaxis due to COVID-19 vaccines in the elderly

Author: Bousquet, Jean, Agache, Ioana, Blain, Hubert, Jutel, Marek, Ventura, Maria Teresa, Worm, Margitta, Del Giacco, Stefano, Benetos, Athanasios, Bilo, Beatrice Maria, Czarlewski, Wienczyslawa, Abdul Latiff, Amir Hamzah, Al-Ahmad, Mona, Angier, Elizabeth, Annesi-Maesano, Isabella, Atanaskovic-Markovic, Marina, Bachert, Claus, Barbaud, Annick, Bedbrook, Anna, Bennoor, Kazi S., Berghea, Elena Camelia, Bindslev-Jensen, Carsten, Bonini, Sergio, Bosnic-Anticevich, Sinthia, Brockow, Knut, Brussino, Luisa, Camargos, Paulo, Canonica, G. Walter, Cardona, Victoria, Carreiro-Martins, Pedro, Carriazo, Ana, Casale, Thomas, Caubet, Jean Christoph, Cecchi, Lorenzo, Cherubini, Antonio, Christoff, George, Chu, Derek K., Cruz, Alvaro A., Dokic, Dejan, El-Gamal, Yehia, Ebisawa, Motohiro, Eberlein, Bernadette, Farrell, John, Fernandez-Rivas, Montserrat, Fokkens, Wytske J., Fonseca, Joao A., Gao, Yadong, Gavazzi, Gaëtan, Gawlik, Radoslaw, Gelincik, Asli, Gemicioğlu, Bilun, Gotua, Maia, Guérin, Olivier, Haahtela, Tari, Hoffmann-Sommergruber, Karin, Hoffmann, Hans Jürgen, Hofmann, Maja, Hrubisko, Martin, Illario, Maddalena, Irani, Carla, Ispayeva, Zhanat, Ivancevich, Juan Carlos, Julge, Kaja, Kaidashev, Igor, Khaitov, Musa, Knol, Edward, Kraxner, Helga, Kuna, Piotr, Kvedariene, Violeta, Lauerma, Antti, Le, Lan T.T., Le Moing, Vincent, Levin, Michael, Louis, Renaud, Lourenco, Olga, Mahler, Vera, Martin, Finbarr C., Matucci, Andrea, Milenkovic, Branislava, Miot, Stéphanie, Montella, Emma, Morais-Almeida, Mario, Mortz, Charlotte G., Mullol, Joaquim, Namazova-Baranova, Leyla, Neffen, Hugo, Nekam, Kristof, Niedoszytko, Marek, Odemyr, Mikaëla, O’Hehir, Robyn E., Okamoto, Yoshitaka, Ollert, Markus, Palomares, Oscar, Papadopoulos, Nikolaos G., Panzner, Petr, Passalacqua, Giovanni, Patella, Vincenzo, Petrovic, Mirko, Pfaar, Oliver, Pham-Thi, Nhân, Plavec, Davor, Popov, Todor A., Recto, Marysia T., Regateiro, Frederico S., Reynes, Jacques, Roller-Winsberger, Regina E., Rolland, Yves, Romano, Antonino, Rondon, Carmen, Rottem, Menachem, Rouadi, Philip W., Salles, Nathalie, Samolinski, Boleslaw, Santos, Alexandra F., S Sarquis, Faradiba, Sastre, Joaquin, M. G. A. Schols, Jos, Scichilone, Nicola, Sediva, Anna, Shamji, Mohamed H., Sheikh, Aziz, Skypala, Isabel, Smolinska, Sylwia, Sokolowska, Milena, Sousa-Pinto, Bernardo, Sova, Milan, Stelmach, Rafael, Sturm, Gunter, Suppli Ulrik, Charlotte, Todo-Bom, Ana Maria, Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Torres, Maria, Untersmayr, Eva, Urrutia Pereira, Marilyn, Valiulis, Arunas, Vitte, Joana, Vultaggio, Alessandra, Wallace, Dana, Walusiak-Skorupa, Jolanta, Wang, De Yun, Waserman, Susan, Yorgancioglu, Arzu, Yusuf, Osman M., Zernotti, Mario, Zidarn, Mihaela, Chivato, Tomas, Akdis, Cezmi A., Zuberbier, Torsten, Klimek, Ludger, Bousquet, Jean, Agache, Ioana, Blain, Hubert, Jutel, Marek, Ventura, Maria Teresa, Worm, Margitta, Del Giacco, Stefano, Benetos, Athanasios, Bilo, Beatrice Maria, Czarlewski, Wienczyslawa, Abdul Latiff, Amir Hamzah, Al-Ahmad, Mona, Angier, Elizabeth, Annesi-Maesano, Isabella, Atanaskovic-Markovic, Marina, Bachert, Claus, Barbaud, Annick, Bedbrook, Anna, Bennoor, Kazi S., Berghea, Elena Camelia, Bindslev-Jensen, Carsten, Bonini, Sergio, Bosnic-Anticevich, Sinthia, Brockow, Knut, Brussino, Luisa, Camargos, Paulo, Canonica, G. Walter, Cardona, Victoria, Carreiro-Martins, Pedro, Carriazo, Ana, Casale, Thomas, Caubet, Jean Christoph, Cecchi, Lorenzo, Cherubini, Antonio, Christoff, George, Chu, Derek K., Cruz, Alvaro A., Dokic, Dejan, El-Gamal, Yehia, Ebisawa, Motohiro, Eberlein, Bernadette, Farrell, John, Fernandez-Rivas, Montserrat, Fokkens, Wytske J., Fonseca, Joao A., Gao, Yadong, Gavazzi, Gaëtan, Gawlik, Radoslaw, Gelincik, Asli, Gemicioğlu, Bilun, Gotua, Maia, Guérin, Olivier, Haahtela, Tari, Hoffmann-Sommergruber, Karin, Hoffmann, Hans Jürgen, Hofmann, Maja, Hrubisko, Martin, Illario, Maddalena, Irani, Carla, Ispayeva, Zhanat, Ivancevich, Juan Carlos, Julge, Kaja, Kaidashev, Igor, Khaitov, Musa, Knol, Edward, Kraxner, Helga, Kuna, Piotr, Kvedariene, Violeta, Lauerma, Antti, Le, Lan T.T., Le Moing, Vincent, Levin, Michael, Louis, Renaud, Lourenco, Olga, Mahler, Vera, Martin, Finbarr C., Matucci, Andrea, Milenkovic, Branislava, Miot, Stéphanie, Montella, Emma, Morais-Almeida, Mario, Mortz, Charlotte G., Mullol, Joaquim, Namazova-Baranova, Leyla, Neffen, Hugo, Nekam, Kristof, Niedoszytko, Marek, Odemyr, Mikaëla, O’Hehir, Robyn E., Okamoto, Yoshitaka, Ollert, Markus, Palomares, Oscar, Papadopoulos, Nikolaos G., Panzner, Petr, Passalacqua, Giovanni, Patella, Vincenzo, Petrovic, Mirko, Pfaar, Oliver, Pham-Thi, Nhân, Plavec, Davor, Popov, Todor A., Recto, Marysia T., Regateiro, Frederico S., Reynes, Jacques, Roller-Winsberger, Regina E., Rolland, Yves, Romano, Antonino, Rondon, Carmen, Rottem, Menachem, Rouadi, Philip W., Salles, Nathalie, Samolinski, Boleslaw, Santos, Alexandra F., S Sarquis, Faradiba, Sastre, Joaquin, M. G. A. Schols, Jos, Scichilone, Nicola, Sediva, Anna, Shamji, Mohamed H., Sheikh, Aziz, Skypala, Isabel, Smolinska, Sylwia, Sokolowska, Milena, Sousa-Pinto, Bernardo, Sova, Milan, Stelmach, Rafael, Sturm, Gunter, Suppli Ulrik, Charlotte, Todo-Bom, Ana Maria, Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Torres, Maria, Untersmayr, Eva, Urrutia Pereira, Marilyn, Valiulis, Arunas, Vitte, Joana, Vultaggio, Alessandra, Wallace, Dana, Walusiak-Skorupa, Jolanta, Wang, De Yun, Waserman, Susan, Yorgancioglu, Arzu, Yusuf, Osman M., Zernotti, Mario, Zidarn, Mihaela, Chivato, Tomas, Akdis, Cezmi A., Zuberbier, Torsten, and Klimek, Ludger
Abstract: Older adults, especially men and/or those with diabetes, hypertension, and/or obesity, are prone to severe COVID-19. In some countries, older adults, particularly those residing in nursing homes, have been prioritized to receive COVID-19 vaccines due to high risk of death. In very rare instances, the COVID-19 vaccines can induce anaphylaxis, and the management of anaphylaxis in older people should be considered carefully. An ARIA-EAACI-EuGMS (Allergic Rhinitis and its Impact on Asthma, European Academy of Allergy and Clinical Immunology, and European Geriatric Medicine Society) Working Group has proposed some recommendations for older adults receiving the COVID-19 vaccines. Anaphylaxis to COVID-19 vaccines is extremely rare (from 1 per 100,000 to 5 per million injections). Symptoms are similar in younger and older adults but they tend to be more severe in the older patients. Adrenaline is the mainstay treatment and should be readily available. A flowchart is proposed to manage anaphylaxis in the older patients.
Published: 2021

9. COVID-19 pandemic:Practical considerations on the organization of an allergy clinic—An EAACI/ARIA Position Paper

Author: Pfaar, Oliver, Klimek, Ludger, Jutel, Marek, Akdis, Cezmi A., Bousquet, Jean, Breiteneder, Heimo, Chinthrajah, Sharon, Diamant, Zuzana, Eiwegger, Thomas, Fokkens, Wytske J., Fritsch, Hans Walter, Nadeau, Kari C., O’Hehir, Robyn E., O’Mahony, Liam, Rief, Winfried, Sampath, Vanitha, Schedlowski, Manfred, Torres, María José, Traidl-Hoffmann, Claudia, Wang, De Yun, Zhang, Luo, Bonini, Matteo, Brehler, Randolf, Brough, Helen Annaruth, Chivato, Tomás, Del Giacco, Stefano R., Dramburg, Stephanie, Gawlik, Radoslaw, Gelincik, Aslı, Hoffmann-Sommergruber, Karin, Hox, Valerie, Knol, Edward F., Lauerma, Antti, Matricardi, Paolo M., Mortz, Charlotte G., Ollert, Markus, Palomares, Oscar, Riggioni, Carmen, Schwarze, Jürgen, Skypala, Isabel, Untersmayr, Eva, Walusiak-Skorupa, Jolanta, Ansotegui, Ignacio J., Bachert, Claus, Bedbrook, Anna, Bosnic-Anticevich, Sinthia, Brussino, Luisa, Canonica, Giorgio Walter, Cardona, Victoria, Carreiro-Martins, Pedro, Cruz, Alvaro A., Czarlewski, Wienczyslawa, Fonseca, João A., Gotua, Maia, Haahtela, Tari, Ivancevich, Juan Carlos, Kuna, Piotr, Kvedariene, Violeta, Larenas-Linnemann, Désirée Erlinda, Abdul Latiff, Amir Hamzah, Mäkelä, Mika, Morais-Almeida, Mário, Mullol, Joaquim, Naclerio, Robert, Ohta, Ken, Okamoto, Yoshitaka, Onorato, Gabrielle L., Papadopoulos, Nikolaos G., Patella, Vincenzo, Regateiro, Frederico S., Samoliński, Bolesław, Suppli Ulrik, Charlotte, Toppila-Salmi, Sanna, Valiulis, Arunas, Ventura, Maria Teresa, Yorgancioglu, Arzu, Zuberbier, Torsten, Agache, Ioana, Pfaar, Oliver, Klimek, Ludger, Jutel, Marek, Akdis, Cezmi A., Bousquet, Jean, Breiteneder, Heimo, Chinthrajah, Sharon, Diamant, Zuzana, Eiwegger, Thomas, Fokkens, Wytske J., Fritsch, Hans Walter, Nadeau, Kari C., O’Hehir, Robyn E., O’Mahony, Liam, Rief, Winfried, Sampath, Vanitha, Schedlowski, Manfred, Torres, María José, Traidl-Hoffmann, Claudia, Wang, De Yun, Zhang, Luo, Bonini, Matteo, Brehler, Randolf, Brough, Helen Annaruth, Chivato, Tomás, Del Giacco, Stefano R., Dramburg, Stephanie, Gawlik, Radoslaw, Gelincik, Aslı, Hoffmann-Sommergruber, Karin, Hox, Valerie, Knol, Edward F., Lauerma, Antti, Matricardi, Paolo M., Mortz, Charlotte G., Ollert, Markus, Palomares, Oscar, Riggioni, Carmen, Schwarze, Jürgen, Skypala, Isabel, Untersmayr, Eva, Walusiak-Skorupa, Jolanta, Ansotegui, Ignacio J., Bachert, Claus, Bedbrook, Anna, Bosnic-Anticevich, Sinthia, Brussino, Luisa, Canonica, Giorgio Walter, Cardona, Victoria, Carreiro-Martins, Pedro, Cruz, Alvaro A., Czarlewski, Wienczyslawa, Fonseca, João A., Gotua, Maia, Haahtela, Tari, Ivancevich, Juan Carlos, Kuna, Piotr, Kvedariene, Violeta, Larenas-Linnemann, Désirée Erlinda, Abdul Latiff, Amir Hamzah, Mäkelä, Mika, Morais-Almeida, Mário, Mullol, Joaquim, Naclerio, Robert, Ohta, Ken, Okamoto, Yoshitaka, Onorato, Gabrielle L., Papadopoulos, Nikolaos G., Patella, Vincenzo, Regateiro, Frederico S., Samoliński, Bolesław, Suppli Ulrik, Charlotte, Toppila-Salmi, Sanna, Valiulis, Arunas, Ventura, Maria Teresa, Yorgancioglu, Arzu, Zuberbier, Torsten, and Agache, Ioana
Abstract: Background: The coronavirus disease 2019 (COVID-19) has evolved into a pandemic infectious disease transmitted by the severe acute respiratory syndrome coronavirus (SARS-CoV-2). Allergists and other healthcare providers (HCPs) in the field of allergies and associated airway diseases are on the front line, taking care of patients potentially infected with SARS-CoV-2. Hence, strategies and practices to minimize risks of infection for both HCPs and treated patients have to be developed and followed by allergy clinics. Method: The scientific information on COVID-19 was analysed by a literature search in MEDLINE, PubMed, the National and International Guidelines from the European Academy of Allergy and Clinical Immunology (EAACI), the Cochrane Library, and the internet. Results: Based on the diagnostic and treatment standards developed by EAACI, on international information regarding COVID-19, on guidelines of the World Health Organization (WHO) and other international organizations, and on previous experience, a panel of experts including clinicians, psychologists, IT experts, and basic scientists along with EAACI and the “Allergic Rhinitis and its Impact on Asthma (ARIA)” initiative have developed recommendations for the optimal management of allergy clinics during the current COVID-19 pandemic. These recommendations are grouped into nine sections on different relevant aspects for the care of patients with allergies. Conclusions: This international Position Paper provides recommendations on operational plans and procedures to maintain high standards in the daily clinical care of allergic patients while ensuring the necessary safety measures in the current COVID-19 pandemic.
Published: 2021

10. Management of anaphylaxis due to COVID-19 vaccines in the elderly

Author: Bousquet, Jean, Agache, Ioana, Blain, Hubert, Jutel, Marek, Ventura, Maria Teresa, Worm, Margitta, Del Giacco, Stefano, Benetos, Athanasios, Bilo, Beatrice Maria, Czarlewski, Wienczyslawa, Abdul Latiff, Amir Hamzah, Al-Ahmad, Mona, Angier, Elizabeth, Annesi-Maesano, Isabella, Atanaskovic-Markovic, Marina, Bachert, Claus, Barbaud, Annick, Bedbrook, Anna, Bennoor, Kazi S., Berghea, Elena Camelia, Bindslev-Jensen, Carsten, Bonini, Sergio, Bosnic-Anticevich, Sinthia, Brockow, Knut, Brussino, Luisa, Camargos, Paulo, Canonica, G. Walter, Cardona, Victoria, Carreiro-Martins, Pedro, Carriazo, Ana, Casale, Thomas, Caubet, Jean Christoph, Cecchi, Lorenzo, Cherubini, Antonio, Christoff, George, Chu, Derek K., Cruz, Alvaro A., Dokic, Dejan, El-Gamal, Yehia, Ebisawa, Motohiro, Eberlein, Bernadette, Farrell, John, Fernandez-Rivas, Montserrat, Fokkens, Wytske J., Fonseca, Joao A., Gao, Yadong, Gavazzi, Gaëtan, Gawlik, Radoslaw, Gelincik, Asli, Gemicioğlu, Bilun, Gotua, Maia, Guérin, Olivier, Haahtela, Tari, Hoffmann-Sommergruber, Karin, Hoffmann, Hans Jürgen, Hofmann, Maja, Hrubisko, Martin, Illario, Maddalena, Irani, Carla, Ispayeva, Zhanat, Ivancevich, Juan Carlos, Julge, Kaja, Kaidashev, Igor, Khaitov, Musa, Knol, Edward, Kraxner, Helga, Kuna, Piotr, Kvedariene, Violeta, Lauerma, Antti, Le, Lan T.T., Le Moing, Vincent, Levin, Michael, Louis, Renaud, Lourenco, Olga, Mahler, Vera, Martin, Finbarr C., Matucci, Andrea, Milenkovic, Branislava, Miot, Stéphanie, Montella, Emma, Morais-Almeida, Mario, Mortz, Charlotte G., Mullol, Joaquim, Namazova-Baranova, Leyla, Neffen, Hugo, Nekam, Kristof, Niedoszytko, Marek, Odemyr, Mikaëla, O’Hehir, Robyn E., Okamoto, Yoshitaka, Ollert, Markus, Palomares, Oscar, Papadopoulos, Nikolaos G., Panzner, Petr, Passalacqua, Giovanni, Patella, Vincenzo, Petrovic, Mirko, Pfaar, Oliver, Pham-Thi, Nhân, Plavec, Davor, Popov, Todor A., Recto, Marysia T., Regateiro, Frederico S., Reynes, Jacques, Roller-Winsberger, Regina E., Rolland, Yves, Romano, Antonino, Rondon, Carmen, Rottem, Menachem, Rouadi, Philip W., Salles, Nathalie, Samolinski, Boleslaw, Santos, Alexandra F., S Sarquis, Faradiba, Sastre, Joaquin, M. G. A. Schols, Jos, Scichilone, Nicola, Sediva, Anna, Shamji, Mohamed H., Sheikh, Aziz, Skypala, Isabel, Smolinska, Sylwia, Sokolowska, Milena, Sousa-Pinto, Bernardo, Sova, Milan, Stelmach, Rafael, Sturm, Gunter, Suppli Ulrik, Charlotte, Todo-Bom, Ana Maria, Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Torres, Maria, Untersmayr, Eva, Urrutia Pereira, Marilyn, Valiulis, Arunas, Vitte, Joana, Vultaggio, Alessandra, Wallace, Dana, Walusiak-Skorupa, Jolanta, Wang, De Yun, Waserman, Susan, Yorgancioglu, Arzu, Yusuf, Osman M., Zernotti, Mario, Zidarn, Mihaela, Chivato, Tomas, Akdis, Cezmi A., Zuberbier, Torsten, Klimek, Ludger, Bousquet, Jean, Agache, Ioana, Blain, Hubert, Jutel, Marek, Ventura, Maria Teresa, Worm, Margitta, Del Giacco, Stefano, Benetos, Athanasios, Bilo, Beatrice Maria, Czarlewski, Wienczyslawa, Abdul Latiff, Amir Hamzah, Al-Ahmad, Mona, Angier, Elizabeth, Annesi-Maesano, Isabella, Atanaskovic-Markovic, Marina, Bachert, Claus, Barbaud, Annick, Bedbrook, Anna, Bennoor, Kazi S., Berghea, Elena Camelia, Bindslev-Jensen, Carsten, Bonini, Sergio, Bosnic-Anticevich, Sinthia, Brockow, Knut, Brussino, Luisa, Camargos, Paulo, Canonica, G. Walter, Cardona, Victoria, Carreiro-Martins, Pedro, Carriazo, Ana, Casale, Thomas, Caubet, Jean Christoph, Cecchi, Lorenzo, Cherubini, Antonio, Christoff, George, Chu, Derek K., Cruz, Alvaro A., Dokic, Dejan, El-Gamal, Yehia, Ebisawa, Motohiro, Eberlein, Bernadette, Farrell, John, Fernandez-Rivas, Montserrat, Fokkens, Wytske J., Fonseca, Joao A., Gao, Yadong, Gavazzi, Gaëtan, Gawlik, Radoslaw, Gelincik, Asli, Gemicioğlu, Bilun, Gotua, Maia, Guérin, Olivier, Haahtela, Tari, Hoffmann-Sommergruber, Karin, Hoffmann, Hans Jürgen, Hofmann, Maja, Hrubisko, Martin, Illario, Maddalena, Irani, Carla, Ispayeva, Zhanat, Ivancevich, Juan Carlos, Julge, Kaja, Kaidashev, Igor, Khaitov, Musa, Knol, Edward, Kraxner, Helga, Kuna, Piotr, Kvedariene, Violeta, Lauerma, Antti, Le, Lan T.T., Le Moing, Vincent, Levin, Michael, Louis, Renaud, Lourenco, Olga, Mahler, Vera, Martin, Finbarr C., Matucci, Andrea, Milenkovic, Branislava, Miot, Stéphanie, Montella, Emma, Morais-Almeida, Mario, Mortz, Charlotte G., Mullol, Joaquim, Namazova-Baranova, Leyla, Neffen, Hugo, Nekam, Kristof, Niedoszytko, Marek, Odemyr, Mikaëla, O’Hehir, Robyn E., Okamoto, Yoshitaka, Ollert, Markus, Palomares, Oscar, Papadopoulos, Nikolaos G., Panzner, Petr, Passalacqua, Giovanni, Patella, Vincenzo, Petrovic, Mirko, Pfaar, Oliver, Pham-Thi, Nhân, Plavec, Davor, Popov, Todor A., Recto, Marysia T., Regateiro, Frederico S., Reynes, Jacques, Roller-Winsberger, Regina E., Rolland, Yves, Romano, Antonino, Rondon, Carmen, Rottem, Menachem, Rouadi, Philip W., Salles, Nathalie, Samolinski, Boleslaw, Santos, Alexandra F., S Sarquis, Faradiba, Sastre, Joaquin, M. G. A. Schols, Jos, Scichilone, Nicola, Sediva, Anna, Shamji, Mohamed H., Sheikh, Aziz, Skypala, Isabel, Smolinska, Sylwia, Sokolowska, Milena, Sousa-Pinto, Bernardo, Sova, Milan, Stelmach, Rafael, Sturm, Gunter, Suppli Ulrik, Charlotte, Todo-Bom, Ana Maria, Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Torres, Maria, Untersmayr, Eva, Urrutia Pereira, Marilyn, Valiulis, Arunas, Vitte, Joana, Vultaggio, Alessandra, Wallace, Dana, Walusiak-Skorupa, Jolanta, Wang, De Yun, Waserman, Susan, Yorgancioglu, Arzu, Yusuf, Osman M., Zernotti, Mario, Zidarn, Mihaela, Chivato, Tomas, Akdis, Cezmi A., Zuberbier, Torsten, and Klimek, Ludger
Abstract: Older adults, especially men and/or those with diabetes, hypertension, and/or obesity, are prone to severe COVID-19. In some countries, older adults, particularly those residing in nursing homes, have been prioritized to receive COVID-19 vaccines due to high risk of death. In very rare instances, the COVID-19 vaccines can induce anaphylaxis, and the management of anaphylaxis in older people should be considered carefully. An ARIA-EAACI-EuGMS (Allergic Rhinitis and its Impact on Asthma, European Academy of Allergy and Clinical Immunology, and European Geriatric Medicine Society) Working Group has proposed some recommendations for older adults receiving the COVID-19 vaccines. Anaphylaxis to COVID-19 vaccines is extremely rare (from 1 per 100,000 to 5 per million injections). Symptoms are similar in younger and older adults but they tend to be more severe in the older patients. Adrenaline is the mainstay treatment and should be readily available. A flowchart is proposed to manage anaphylaxis in the older patients.
Published: 2021

11. COVID-19 pandemic and allergen immunotherapy - an EAACI survey

Author: CTI Research, MS Dermatologie/Allergologie, Infection & Immunity, Pfaar, Oliver, Agache, Ioana, Bonini, Matteo, Brough, Helen Annaruth, Chivato, Tomás, Del Giacco, Stefano R, Gawlik, Radoslaw, Gelincik, Aslı, Hoffmann-Sommergruber, Karin, Jutel, Marek, Klimek, Ludger, Knol, Edward F, Lauerma, Antti, Ollert, Markus, O'Mahony, Liam, Mortz, Charlotte G, Palomares, Oscar, Riggioni, Carmen, Schwarze, Jürgen, Skypala, Isabel, Torres, María José, Untersmayr, Eva, Walusiak-Skorupa, Jolanta, Chaker, Adam, Giovannini, Mattia, Heffler, Enrico, Jensen-Jarolim, Erika, Quecchia, Cristina, Sandoval-Ruballos, Mónica, Sahiner, Umit, Tomić Spirić, Vesna, Alvaro-Lozano, Montserrat, CTI Research, MS Dermatologie/Allergologie, Infection & Immunity, Pfaar, Oliver, Agache, Ioana, Bonini, Matteo, Brough, Helen Annaruth, Chivato, Tomás, Del Giacco, Stefano R, Gawlik, Radoslaw, Gelincik, Aslı, Hoffmann-Sommergruber, Karin, Jutel, Marek, Klimek, Ludger, Knol, Edward F, Lauerma, Antti, Ollert, Markus, O'Mahony, Liam, Mortz, Charlotte G, Palomares, Oscar, Riggioni, Carmen, Schwarze, Jürgen, Skypala, Isabel, Torres, María José, Untersmayr, Eva, Walusiak-Skorupa, Jolanta, Chaker, Adam, Giovannini, Mattia, Heffler, Enrico, Jensen-Jarolim, Erika, Quecchia, Cristina, Sandoval-Ruballos, Mónica, Sahiner, Umit, Tomić Spirić, Vesna, and Alvaro-Lozano, Montserrat
Published: 2021

12. Machine-learning-driven biomarker discovery for the discrimination between allergic and irritant contact dermatitis

Author: Fortino, Vittorio, Wisgrill, Lukas, Werner, Paulina, Suomela, Sari, Linder, Nina, Jalonen, Erja, Suomalainen, Alina, Marwah, Veer, Kero, Mia, Pesonen, Maria, Lundin, Johan, Lauerma, Antti, Aalto-Korte, Kristiina, Greco, Dario, Alenius, Harri, Fyhrquist, Nanna, Fortino, Vittorio, Wisgrill, Lukas, Werner, Paulina, Suomela, Sari, Linder, Nina, Jalonen, Erja, Suomalainen, Alina, Marwah, Veer, Kero, Mia, Pesonen, Maria, Lundin, Johan, Lauerma, Antti, Aalto-Korte, Kristiina, Greco, Dario, Alenius, Harri, and Fyhrquist, Nanna
Abstract: Contact dermatitis tremendously impacts the quality of life of suffering patients. Currently, diagnostic regimes rely on allergy testing, exposure specification, and follow-up visits; however, distinguishing the clinical phenotype of irritant and allergic contact dermatitis remains challenging. Employing integrative transcriptomic analysis and machine-learning approaches, we aimed to decipher disease-related signature genes to find suitable sets of biomarkers. A total of 89 positive patch-test reaction biopsies against four contact allergens and two irritants were analyzed via microarray. Coexpression network analysis and Random Forest classification were used to discover potential biomarkers and selected biomarker models were validated in an independent patient group. Differential gene-expression analysis identified major gene-expression changes depending on the stimulus. Random Forest classification identified CD47, BATF, FASLG, RGS16, SYNPO, SELE, PTPN7, WARS, PRC1, EXO1, RRM2, PBK, RAD54L, KIFC1, SPC25, PKMYT, HISTH1A, TPX2, DLGAP5, TPX2, CH25H, and IL37 as potential biomarkers to distinguish allergic and irritant contact dermatitis in human skin. Validation experiments and prediction performances on external testing datasets demonstrated potential applicability of the identified biomarker models in the clinic. Capitalizing on this knowledge, novel diagnostic tools can be developed to guide clinical diagnosis of contact allergies.
Published: 2020
Full Text: View/download PDF

13. Machine-learning-driven biomarker discovery for the discrimination between allergic and irritant contact dermatitis

Author: Fortino, Vittorio, Wisgrill, Lukas, Werner, Paulina, Suomela, Sari, Linder, Nina, Jalonen, Erja, Suomalainen, Alina, Marwah, Veer, Kero, Mia, Pesonen, Maria, Lundin, Johan, Lauerma, Antti, Aalto-Korte, Kristiina, Greco, Dario, Alenius, Harri, Fyhrquist, Nanna, Fortino, Vittorio, Wisgrill, Lukas, Werner, Paulina, Suomela, Sari, Linder, Nina, Jalonen, Erja, Suomalainen, Alina, Marwah, Veer, Kero, Mia, Pesonen, Maria, Lundin, Johan, Lauerma, Antti, Aalto-Korte, Kristiina, Greco, Dario, Alenius, Harri, and Fyhrquist, Nanna
Abstract: Contact dermatitis tremendously impacts the quality of life of suffering patients. Currently, diagnostic regimes rely on allergy testing, exposure specification, and follow-up visits; however, distinguishing the clinical phenotype of irritant and allergic contact dermatitis remains challenging. Employing integrative transcriptomic analysis and machine-learning approaches, we aimed to decipher disease-related signature genes to find suitable sets of biomarkers. A total of 89 positive patch-test reaction biopsies against four contact allergens and two irritants were analyzed via microarray. Coexpression network analysis and Random Forest classification were used to discover potential biomarkers and selected biomarker models were validated in an independent patient group. Differential gene-expression analysis identified major gene-expression changes depending on the stimulus. Random Forest classification identified CD47, BATF, FASLG, RGS16, SYNPO, SELE, PTPN7, WARS, PRC1, EXO1, RRM2, PBK, RAD54L, KIFC1, SPC25, PKMYT, HISTH1A, TPX2, DLGAP5, TPX2, CH25H, and IL37 as potential biomarkers to distinguish allergic and irritant contact dermatitis in human skin. Validation experiments and prediction performances on external testing datasets demonstrated potential applicability of the identified biomarker models in the clinic. Capitalizing on this knowledge, novel diagnostic tools can be developed to guide clinical diagnosis of contact allergies.
Published: 2020
Full Text: View/download PDF

14. Machine-learning-driven biomarker discovery for the discrimination between allergic and irritant contact dermatitis

Author: Fortino, Vittorio, Wisgrill, Lukas, Werner, Paulina, Suomela, Sari, Linder, Nina, Jalonen, Erja, Suomalainen, Alina, Marwah, Veer, Kero, Mia, Pesonen, Maria, Lundin, Johan, Lauerma, Antti, Aalto-Korte, Kristiina, Greco, Dario, Alenius, Harri, Fyhrquist, Nanna, Fortino, Vittorio, Wisgrill, Lukas, Werner, Paulina, Suomela, Sari, Linder, Nina, Jalonen, Erja, Suomalainen, Alina, Marwah, Veer, Kero, Mia, Pesonen, Maria, Lundin, Johan, Lauerma, Antti, Aalto-Korte, Kristiina, Greco, Dario, Alenius, Harri, and Fyhrquist, Nanna
Abstract: Contact dermatitis tremendously impacts the quality of life of suffering patients. Currently, diagnostic regimes rely on allergy testing, exposure specification, and follow-up visits; however, distinguishing the clinical phenotype of irritant and allergic contact dermatitis remains challenging. Employing integrative transcriptomic analysis and machine-learning approaches, we aimed to decipher disease-related signature genes to find suitable sets of biomarkers. A total of 89 positive patch-test reaction biopsies against four contact allergens and two irritants were analyzed via microarray. Coexpression network analysis and Random Forest classification were used to discover potential biomarkers and selected biomarker models were validated in an independent patient group. Differential gene-expression analysis identified major gene-expression changes depending on the stimulus. Random Forest classification identified CD47, BATF, FASLG, RGS16, SYNPO, SELE, PTPN7, WARS, PRC1, EXO1, RRM2, PBK, RAD54L, KIFC1, SPC25, PKMYT, HISTH1A, TPX2, DLGAP5, TPX2, CH25H, and IL37 as potential biomarkers to distinguish allergic and irritant contact dermatitis in human skin. Validation experiments and prediction performances on external testing datasets demonstrated potential applicability of the identified biomarker models in the clinic. Capitalizing on this knowledge, novel diagnostic tools can be developed to guide clinical diagnosis of contact allergies.
Published: 2020
Full Text: View/download PDF

15. Machine-learning-driven biomarker discovery for the discrimination between allergic and irritant contact dermatitis

Author: Fortino, Vittorio, Wisgrill, Lukas, Werner, Paulina, Suomela, Sari, Linder, Nina, Jalonen, Erja, Suomalainen, Alina, Marwah, Veer, Kero, Mia, Pesonen, Maria, Lundin, Johan, Lauerma, Antti, Aalto-Korte, Kristiina, Greco, Dario, Alenius, Harri, Fyhrquist, Nanna, Fortino, Vittorio, Wisgrill, Lukas, Werner, Paulina, Suomela, Sari, Linder, Nina, Jalonen, Erja, Suomalainen, Alina, Marwah, Veer, Kero, Mia, Pesonen, Maria, Lundin, Johan, Lauerma, Antti, Aalto-Korte, Kristiina, Greco, Dario, Alenius, Harri, and Fyhrquist, Nanna
Abstract: Contact dermatitis tremendously impacts the quality of life of suffering patients. Currently, diagnostic regimes rely on allergy testing, exposure specification, and follow-up visits; however, distinguishing the clinical phenotype of irritant and allergic contact dermatitis remains challenging. Employing integrative transcriptomic analysis and machine-learning approaches, we aimed to decipher disease-related signature genes to find suitable sets of biomarkers. A total of 89 positive patch-test reaction biopsies against four contact allergens and two irritants were analyzed via microarray. Coexpression network analysis and Random Forest classification were used to discover potential biomarkers and selected biomarker models were validated in an independent patient group. Differential gene-expression analysis identified major gene-expression changes depending on the stimulus. Random Forest classification identified CD47, BATF, FASLG, RGS16, SYNPO, SELE, PTPN7, WARS, PRC1, EXO1, RRM2, PBK, RAD54L, KIFC1, SPC25, PKMYT, HISTH1A, TPX2, DLGAP5, TPX2, CH25H, and IL37 as potential biomarkers to distinguish allergic and irritant contact dermatitis in human skin. Validation experiments and prediction performances on external testing datasets demonstrated potential applicability of the identified biomarker models in the clinic. Capitalizing on this knowledge, novel diagnostic tools can be developed to guide clinical diagnosis of contact allergies.
Published: 2020
Full Text: View/download PDF

16. Machine-learning-driven biomarker discovery for the discrimination between allergic and irritant contact dermatitis

Author: Fortino, Vittorio, Wisgrill, Lukas, Werner, Paulina, Suomela, Sari, Linder, Nina, Jalonen, Erja, Suomalainen, Alina, Marwah, Veer, Kero, Mia, Pesonen, Maria, Lundin, Johan, Lauerma, Antti, Aalto-Korte, Kristiina, Greco, Dario, Alenius, Harri, Fyhrquist, Nanna, Fortino, Vittorio, Wisgrill, Lukas, Werner, Paulina, Suomela, Sari, Linder, Nina, Jalonen, Erja, Suomalainen, Alina, Marwah, Veer, Kero, Mia, Pesonen, Maria, Lundin, Johan, Lauerma, Antti, Aalto-Korte, Kristiina, Greco, Dario, Alenius, Harri, and Fyhrquist, Nanna
Abstract: Contact dermatitis tremendously impacts the quality of life of suffering patients. Currently, diagnostic regimes rely on allergy testing, exposure specification, and follow-up visits; however, distinguishing the clinical phenotype of irritant and allergic contact dermatitis remains challenging. Employing integrative transcriptomic analysis and machine-learning approaches, we aimed to decipher disease-related signature genes to find suitable sets of biomarkers. A total of 89 positive patch-test reaction biopsies against four contact allergens and two irritants were analyzed via microarray. Coexpression network analysis and Random Forest classification were used to discover potential biomarkers and selected biomarker models were validated in an independent patient group. Differential gene-expression analysis identified major gene-expression changes depending on the stimulus. Random Forest classification identified CD47, BATF, FASLG, RGS16, SYNPO, SELE, PTPN7, WARS, PRC1, EXO1, RRM2, PBK, RAD54L, KIFC1, SPC25, PKMYT, HISTH1A, TPX2, DLGAP5, TPX2, CH25H, and IL37 as potential biomarkers to distinguish allergic and irritant contact dermatitis in human skin. Validation experiments and prediction performances on external testing datasets demonstrated potential applicability of the identified biomarker models in the clinic. Capitalizing on this knowledge, novel diagnostic tools can be developed to guide clinical diagnosis of contact allergies.
Published: 2020
Full Text: View/download PDF

17. Skin Microbiome in Cutaneous T-Cell Lymphoma by 16S and Whole-Genome Shotgun Sequencing

Author: Salava, Alexander, Deptula, Paulina, Lyyski, Annina, Laine, Pia, Paulin, Lars, Väkevä, Liisa, Ranki, Annamari, Auvinen, Petri, Lauerma, Antti, Salava, Alexander, Deptula, Paulina, Lyyski, Annina, Laine, Pia, Paulin, Lars, Väkevä, Liisa, Ranki, Annamari, Auvinen, Petri, and Lauerma, Antti
Published: 2020

18. Skin Microbiome in Cutaneous T-Cell Lymphoma by 16S and Whole-Genome Shotgun Sequencing

Author: Salava, Alexander, Deptula, Paulina, Lyyski, Annina, Laine, Pia, Paulin, Lars, Väkevä, Liisa, Ranki, Annamari, Auvinen, Petri, Lauerma, Antti, Salava, Alexander, Deptula, Paulina, Lyyski, Annina, Laine, Pia, Paulin, Lars, Väkevä, Liisa, Ranki, Annamari, Auvinen, Petri, and Lauerma, Antti
Published: 2020

19. Machine-learning-driven biomarker discovery for the discrimination between allergic and irritant contact dermatitis

Author: Fortino, Vittorio, Wisgrill, Lukas, Werner, Paulina, Suomela, Sari, Linder, Nina, Jalonen, Erja, Suomalainen, Alina, Marwah, Veer, Kero, Mia, Pesonen, Maria, Lundin, Johan, Lauerma, Antti, Aalto-Korte, Kristiina, Greco, Dario, Alenius, Harri, Fyhrquist, Nanna, Fortino, Vittorio, Wisgrill, Lukas, Werner, Paulina, Suomela, Sari, Linder, Nina, Jalonen, Erja, Suomalainen, Alina, Marwah, Veer, Kero, Mia, Pesonen, Maria, Lundin, Johan, Lauerma, Antti, Aalto-Korte, Kristiina, Greco, Dario, Alenius, Harri, and Fyhrquist, Nanna
Abstract: Contact dermatitis tremendously impacts the quality of life of suffering patients. Currently, diagnostic regimes rely on allergy testing, exposure specification, and follow-up visits; however, distinguishing the clinical phenotype of irritant and allergic contact dermatitis remains challenging. Employing integrative transcriptomic analysis and machine-learning approaches, we aimed to decipher disease-related signature genes to find suitable sets of biomarkers. A total of 89 positive patch-test reaction biopsies against four contact allergens and two irritants were analyzed via microarray. Coexpression network analysis and Random Forest classification were used to discover potential biomarkers and selected biomarker models were validated in an independent patient group. Differential gene-expression analysis identified major gene-expression changes depending on the stimulus. Random Forest classification identified CD47, BATF, FASLG, RGS16, SYNPO, SELE, PTPN7, WARS, PRC1, EXO1, RRM2, PBK, RAD54L, KIFC1, SPC25, PKMYT, HISTH1A, TPX2, DLGAP5, TPX2, CH25H, and IL37 as potential biomarkers to distinguish allergic and irritant contact dermatitis in human skin. Validation experiments and prediction performances on external testing datasets demonstrated potential applicability of the identified biomarker models in the clinic. Capitalizing on this knowledge, novel diagnostic tools can be developed to guide clinical diagnosis of contact allergies.
Published: 2020
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20. Skin Microbiome in Small- and Large-plaque Parapsoriasis

Author: University of Helsinki, Departments of Dermatology, Allergology and Venereology, University of Helsinki, Institute of Biotechnology, University of Helsinki, Clinicum, Salava, Alexander, Pereira, Pedro, Aho, Velma, Vakeva, Liisa, Paulin, Lars, Auvinen, Petri, Ranki, Annamari, Lauerma, Antti, University of Helsinki, Departments of Dermatology, Allergology and Venereology, University of Helsinki, Institute of Biotechnology, University of Helsinki, Clinicum, Salava, Alexander, Pereira, Pedro, Aho, Velma, Vakeva, Liisa, Paulin, Lars, Auvinen, Petri, Ranki, Annamari, and Lauerma, Antti
Abstract: Staphylococcal enterotoxins have been shown to promote lymphoma-associated immune dysregulation. This study examined changes in the skin microbiome of parapsoriasis compared with intact skin. Swab microbiome specimens were taken of the parapsoriasis lesions of 13 patients. Control samples were taken from contralateral healthy sides of the body. Micro-biotas were characterized by sequencing the V1-V3 region of the 16S ribosomal RNA bacterial genes on the Illumina MiSeq platform. The most common genera in the microbiome data were Propionibacterium (27.13%), Corynebacterium (21.20%) and Staphylococcus (4.63%). Out of the Staphylococcus sequences, 39.6% represented S. epidermidis, with the rest including S. hominis, S. capitis and unidentified species. No significant differences were observed between the patients' parapsoriasis and contralateral healthy skin or between large-and small-plaque parapsoriasis. Notable interpersonal variation was demonstrated. These results suggest that parapsoriasis is not associated with significant alterations in the cutaneous bacterial microbiome.
Published: 2017

21. Research needs in allergy: an EAACI position paper, in collaboration with EFA

Author: KUL - University Hospitals Leuven, Spertini, Francois, Sokolowska, Milena, Skypala, Isabel, Spiewak, Radoslaw, Sprikkelman, Aline, Alves, Rodrigo, Sturm, Gunter, Siracusa, Andrea, Seys, Sven, Vlieg-Boerstra, Berber, Venter, Carina, Whitacker, Paul, Swoboda, Ines, Terreehorst, Ingrid, Traidl-Hoffmann, Claudia, Toskala, Elina, Robson-Ansley, Paula, Roje, Zeljka, Schnyder, Benno, Schmidt-Weber, Carsten, Scharf, Christian, Schwarze, Jürgen, Senna, Gianenrico, Akdis, Cezmi A, Sergejeva, Svetlana, Santucci, Annalisa, Santos, Alexandra F, Rudzeviciene, Odilija, Rondon, Carmen, Ruëff, Franziska, Rukhadze, Maia, Sackesen, Cansin, Rumi, Gabriele, Xepapadaki, Paraskevi, Worm, Margitta, Papadopoulos, Nikolaos G, Agache, Ioana, Bavbek, Sevim, Bilo, Beatrice M, Braido, Fulvio, Cardona, Victoria, Custovic, Adnan, deMonchy, Jan, Demoly, Pascal, Eigenmann, Philippe, Gayraud, Jacques, Grattan, Clive, Heffler, Enrico, Hellings, Peter W, Jutel, Marek, Knol, Edward, Lötvall, Jan, Muraro, Antonella, Poulsen, Lars K, Roberts, Graham, Schmid-Grendelmeier, Peter, Skevaki, Chrysanthi, Triggiani, Massimo, vanRee, Ronald, Werfel, Thomas, Flood, Breda, Palkonen, Susanna, Savli, Roberta, Allegri, Pia, Annesi-Maesano, Isabella, Annunziato, Francesco, Antolin-Amerigo, Dario, Apfelbacher, Christian, Blanca, Miguel, Bogacka, Ewa, Bonadonna, Patrizia, Bonini, Matteo, Boyman, Onur, Brockow, Knut, Burney, Peter, Buters, Jeroen, Butiene, Indre, Calderon, Moises, Cardell, Lars, Caubet, Jean-Christoph, Celenk, Sevcan, Cichocka-Jarosz, Ewa, Cingi, Cemal, Couto, Mariana, deJong, Nicolette, Del Giacco, Stefano, Douladiris, Nikolaos, Fassio, Filippo, Fauquert, Jean-Luc, Fernandez, Javier, Rivas, Montserrat, Ferrer, Marta, Flohr, Carsten, Gardner, James, Genuneit, Jon, Gevaert, Philippe, Groblewska, Anna, Hamelmann, Eckard, Hoffmann, Hans, Hoffmann-Sommergruber, Karin, Hovhannisyan, Lilit, Hox, Valérie, Jahnsen, Frode L, Kalayci, Ömer, Kalpaklioglu, Ayse, Kleine-Tebbe, Jörg, Konstantinou, George, Kurowski, Marcin, Lau, Susanne, Lauener, Roger, Lauerma, Antti, Logan, Kirsty, Magnan, Antoine, Makowska, Joanna, Makrinioti, Heidi, Mangina, Paraskevi, Manole, Felicia, Mari, Adriano, Mazon, Angel, Mills, Clare, Mingomataj, ErvinÇ, Niggemann, Bodo, Nilsson, Gunnar, Ollert, Markus, O'Mahony, Liam, O'Neil, Serena, Pala, Gianni, Papi, Alberto, Passalacqua, Gianni, Perkin, Michael, Pfaar, Oliver, Pitsios, Constantinos, Quirce, Santiago, Raap, Ulrike, Raulf-Heimsoth, Monika, Rhyner, Claudio, KUL - University Hospitals Leuven, Spertini, Francois, Sokolowska, Milena, Skypala, Isabel, Spiewak, Radoslaw, Sprikkelman, Aline, Alves, Rodrigo, Sturm, Gunter, Siracusa, Andrea, Seys, Sven, Vlieg-Boerstra, Berber, Venter, Carina, Whitacker, Paul, Swoboda, Ines, Terreehorst, Ingrid, Traidl-Hoffmann, Claudia, Toskala, Elina, Robson-Ansley, Paula, Roje, Zeljka, Schnyder, Benno, Schmidt-Weber, Carsten, Scharf, Christian, Schwarze, Jürgen, Senna, Gianenrico, Akdis, Cezmi A, Sergejeva, Svetlana, Santucci, Annalisa, Santos, Alexandra F, Rudzeviciene, Odilija, Rondon, Carmen, Ruëff, Franziska, Rukhadze, Maia, Sackesen, Cansin, Rumi, Gabriele, Xepapadaki, Paraskevi, Worm, Margitta, Papadopoulos, Nikolaos G, Agache, Ioana, Bavbek, Sevim, Bilo, Beatrice M, Braido, Fulvio, Cardona, Victoria, Custovic, Adnan, deMonchy, Jan, Demoly, Pascal, Eigenmann, Philippe, Gayraud, Jacques, Grattan, Clive, Heffler, Enrico, Hellings, Peter W, Jutel, Marek, Knol, Edward, Lötvall, Jan, Muraro, Antonella, Poulsen, Lars K, Roberts, Graham, Schmid-Grendelmeier, Peter, Skevaki, Chrysanthi, Triggiani, Massimo, vanRee, Ronald, Werfel, Thomas, Flood, Breda, Palkonen, Susanna, Savli, Roberta, Allegri, Pia, Annesi-Maesano, Isabella, Annunziato, Francesco, Antolin-Amerigo, Dario, Apfelbacher, Christian, Blanca, Miguel, Bogacka, Ewa, Bonadonna, Patrizia, Bonini, Matteo, Boyman, Onur, Brockow, Knut, Burney, Peter, Buters, Jeroen, Butiene, Indre, Calderon, Moises, Cardell, Lars, Caubet, Jean-Christoph, Celenk, Sevcan, Cichocka-Jarosz, Ewa, Cingi, Cemal, Couto, Mariana, deJong, Nicolette, Del Giacco, Stefano, Douladiris, Nikolaos, Fassio, Filippo, Fauquert, Jean-Luc, Fernandez, Javier, Rivas, Montserrat, Ferrer, Marta, Flohr, Carsten, Gardner, James, Genuneit, Jon, Gevaert, Philippe, Groblewska, Anna, Hamelmann, Eckard, Hoffmann, Hans, Hoffmann-Sommergruber, Karin, Hovhannisyan, Lilit, Hox, Valérie, Jahnsen, Frode L, Kalayci, Ömer, Kalpaklioglu, Ayse, Kleine-Tebbe, Jörg, Konstantinou, George, Kurowski, Marcin, Lau, Susanne, Lauener, Roger, Lauerma, Antti, Logan, Kirsty, Magnan, Antoine, Makowska, Joanna, Makrinioti, Heidi, Mangina, Paraskevi, Manole, Felicia, Mari, Adriano, Mazon, Angel, Mills, Clare, Mingomataj, ErvinÇ, Niggemann, Bodo, Nilsson, Gunnar, Ollert, Markus, O'Mahony, Liam, O'Neil, Serena, Pala, Gianni, Papi, Alberto, Passalacqua, Gianni, Perkin, Michael, Pfaar, Oliver, Pitsios, Constantinos, Quirce, Santiago, Raap, Ulrike, Raulf-Heimsoth, Monika, and Rhyner, Claudio
Abstract: In less than half a century, allergy, originally perceived as a rare disease, has become a major public health threat, today affecting the lives of more than 60 million people in Europe, and probably close to one billion worldwide, thereby heavily impacting the budgets of public health systems. More disturbingly, its prevalence and impact are on the rise, a development that has been associated with environmental and lifestyle changes accompanying the continuous process of urbanization and globalization. Therefore, there is an urgent need to prioritize and concert research efforts in the field of allergy, in order to achieve sustainable results on prevention, diagnosis and treatment of this most prevalent chronic disease of the 21st century.The European Academy of Allergy and Clinical Immunology (EAACI) is the leading professional organization in the field of allergy, promoting excellence in clinical care, education, training and basic and translational research, all with the ultimate goal of improving the health of allergic patients. The European Federation of Allergy and Airways Diseases Patients' Associations (EFA) is a non-profit network of allergy, asthma and Chronic Obstructive Pulmonary Disorder (COPD) patients' organizations. In support of their missions, the present EAACI Position Paper, in collaboration with EFA, highlights the most important research needs in the field of allergy to serve as key recommendations for future research funding at the national and European levels.Although allergies may involve almost every organ of the body and an array of diverse external factors act as triggers, there are several common themes that need to be prioritized in research efforts. As in many other chronic diseases, effective prevention, curative treatment and accurate, rapid diagnosis represent major unmet needs. Detailed phenotyping/endotyping stands out as widely required in order to arrange or re-categorize clinical syndromes into more coherent, uniform and treat
Published: 2012

22. CD8+T Cell Migration to the Skin Requires CD4+Help in a Murine Model of Contact Hypersensitivity

Author: University of Helsinki, Haartman Institute, University of Helsinki, Clinicum, Fyhrquist, Nanna, Wolff, Henrik, Lauerma, Antti, Alenius, Harri, University of Helsinki, Haartman Institute, University of Helsinki, Clinicum, Fyhrquist, Nanna, Wolff, Henrik, Lauerma, Antti, and Alenius, Harri
Published: 2012

23. Research needs in allergy:An EAACI position paper, in collaboration with EFA

Author: Papadopoulos, Nikolaos G., Agache, Ioana, Bavbek, Sevim, Bilo, Beatrice M., Braido, Fulvio, Cardona, Victoria, Custovic, Adnan, DeMonchy, Jan, Demoly, Pascal, Eigenmann, Philippe, Gayraud, Jacques, Grattan, Clive, Heffler, Enrico, Hellings, Peter W., Jutel, Marek, Knol, Edward, Lötvall, Jan, Muraro, Antonella, Poulsen, Lars K., Roberts, Graham, Schmid-Grendelmeier, Peter, Skevaki, Chrysanthi, Triggiani, Massimo, VanRee, Ronald, Werfel, Thomas, Flood, Breda, Palkonen, Susanna, Savli, Roberta, Allegri, Pia, Annesi-Maesano, Isabella, Annunziato, Francesco, Antolin-Amerigo, Dario, Apfelbacher, Christian, Blanca, Miguel, Bogacka, Ewa, Bonadonna, Patrizia, Bonini, Matteo, Boyman, Onur, Brockow, Knut, Burney, Peter, Butiene, Indre, Calderon, Moises, Cardell, Lars Olaf, Caubet, Jean Christoph, Celenk, Sevcan, Cichocka-Jarosz, Ewa, Cingi, Cemal, Couto, Mariana, DeJong, Nicolette, Del Giacco, Stefano, Douladiris, Nikolaos, Fassio, Filippo, Fauquert, Jean Luc, Fernandez, Javier, Rivas, Montserrat Fernandez, Ferrer, Marta, Flohr, Carsten, Gardner, James, Genuneit, Jon, Gevaert, Philippe, Groblewska, Anna, Hamelmann, Eckard, Hoffmann, Hans Jürgen, Hoffmann-Sommergruber, Karin, Hovhannisyan, Lilit, Hox, Valérie, Jahnsen, Frode L., Kalayci, Ömer, Kalpaklioglu, Ayse Füsun, Kleine-Tebbe, Jörg, Konstantinou, George, Kurowski, Marcin, Lau, Susanne, Lauener, Roger, Lauerma, Antti, Logan, Kirsty, Magnan, Antoine, Makowska, Joanna, Makrinioti, Heidi, Mangina, Paraskevi, Manole, Felicia, Mari, Adriano, Mazon, Angel, Mills, Clare, Mingomataj, Ervin, Niggemann, Bodo, Nilsson, Gunnar, Ollert, Markus, O'Mahony, Liam, O'Neil, Serena, Papi, Alberto, Passalacqua, Gianni, Perkin, Michael, Pfaar, Oliver, Pitsios, Constantinos, Quirce, Santiago, Raap, Ulrike, Raulf-Heimsoth, Monika, Rhyner, Claudio, Robson-Ansley, Paula, Roje, Zeljka, Rondon, Carmen, Rudzeviciene, Odilija, Ruëff, Franziska, Rukhadze, Maia, Rumi, Gabriele, Sackesen, Cansin, Santos, Alexandra F., Santucci, Annalisa, Scharf, Christian, Schmidt-Weber, Carsten, Schnyder, Benno, Schwarze, Jürgen, Senna, Gianenrico, Sergejeva, Svetlana, Seys, Sven, Siracusa, Andrea, Skypala, Isabel, Sokolowska, Milena, Spertini, Francois, Spiewak, Radoslaw, Sprikkelman, Aline, Sturm, Gunter, Swoboda, Ines, Terreehorst, Ingrid, Toskala, Elina, Traidl-Hoffmann, Claudia, Venter, Carina, Vlieg-Boerstra, Berber, Whitacker, Paul, Worm, Margitta, Xepapadaki, Paraskevi, Akdis, Cezmi A., Papadopoulos, Nikolaos G., Agache, Ioana, Bavbek, Sevim, Bilo, Beatrice M., Braido, Fulvio, Cardona, Victoria, Custovic, Adnan, DeMonchy, Jan, Demoly, Pascal, Eigenmann, Philippe, Gayraud, Jacques, Grattan, Clive, Heffler, Enrico, Hellings, Peter W., Jutel, Marek, Knol, Edward, Lötvall, Jan, Muraro, Antonella, Poulsen, Lars K., Roberts, Graham, Schmid-Grendelmeier, Peter, Skevaki, Chrysanthi, Triggiani, Massimo, VanRee, Ronald, Werfel, Thomas, Flood, Breda, Palkonen, Susanna, Savli, Roberta, Allegri, Pia, Annesi-Maesano, Isabella, Annunziato, Francesco, Antolin-Amerigo, Dario, Apfelbacher, Christian, Blanca, Miguel, Bogacka, Ewa, Bonadonna, Patrizia, Bonini, Matteo, Boyman, Onur, Brockow, Knut, Burney, Peter, Butiene, Indre, Calderon, Moises, Cardell, Lars Olaf, Caubet, Jean Christoph, Celenk, Sevcan, Cichocka-Jarosz, Ewa, Cingi, Cemal, Couto, Mariana, DeJong, Nicolette, Del Giacco, Stefano, Douladiris, Nikolaos, Fassio, Filippo, Fauquert, Jean Luc, Fernandez, Javier, Rivas, Montserrat Fernandez, Ferrer, Marta, Flohr, Carsten, Gardner, James, Genuneit, Jon, Gevaert, Philippe, Groblewska, Anna, Hamelmann, Eckard, Hoffmann, Hans Jürgen, Hoffmann-Sommergruber, Karin, Hovhannisyan, Lilit, Hox, Valérie, Jahnsen, Frode L., Kalayci, Ömer, Kalpaklioglu, Ayse Füsun, Kleine-Tebbe, Jörg, Konstantinou, George, Kurowski, Marcin, Lau, Susanne, Lauener, Roger, Lauerma, Antti, Logan, Kirsty, Magnan, Antoine, Makowska, Joanna, Makrinioti, Heidi, Mangina, Paraskevi, Manole, Felicia, Mari, Adriano, Mazon, Angel, Mills, Clare, Mingomataj, Ervin, Niggemann, Bodo, Nilsson, Gunnar, Ollert, Markus, O'Mahony, Liam, O'Neil, Serena, Papi, Alberto, Passalacqua, Gianni, Perkin, Michael, Pfaar, Oliver, Pitsios, Constantinos, Quirce, Santiago, Raap, Ulrike, Raulf-Heimsoth, Monika, Rhyner, Claudio, Robson-Ansley, Paula, Roje, Zeljka, Rondon, Carmen, Rudzeviciene, Odilija, Ruëff, Franziska, Rukhadze, Maia, Rumi, Gabriele, Sackesen, Cansin, Santos, Alexandra F., Santucci, Annalisa, Scharf, Christian, Schmidt-Weber, Carsten, Schnyder, Benno, Schwarze, Jürgen, Senna, Gianenrico, Sergejeva, Svetlana, Seys, Sven, Siracusa, Andrea, Skypala, Isabel, Sokolowska, Milena, Spertini, Francois, Spiewak, Radoslaw, Sprikkelman, Aline, Sturm, Gunter, Swoboda, Ines, Terreehorst, Ingrid, Toskala, Elina, Traidl-Hoffmann, Claudia, Venter, Carina, Vlieg-Boerstra, Berber, Whitacker, Paul, Worm, Margitta, Xepapadaki, Paraskevi, and Akdis, Cezmi A.
Abstract: In less than half a century, allergy, originally perceived as a rare disease, has become a major public health threat, today affecting the lives of more than 60 million people in Europe, and probably close to one billion worldwide, thereby heavily impacting the budgets of public health systems. More disturbingly, its prevalence and impact are on the rise, a development that has been associated with environmental and lifestyle changes accompanying the continuous process of urbanization and globalization. Therefore, there is an urgent need to prioritize and concert research efforts in the field of allergy, in order to achieve sustainable results on prevention, diagnosis and treatment of this most prevalent chronic disease of the 21st century. The European Academy of Allergy and Clinical Immunology (EAACI) is the leading professional organization in the field of allergy, promoting excellence in clinical care, education, training and basic and translational research, all with the ultimate goal of improving the health of allergic patients. The European Federation of Allergy and Airways Diseases Patients' Associations (EFA) is a non-profit network of allergy, asthma and Chronic Obstructive Pulmonary Disorder (COPD) patients' organizations. In support of their missions, the present EAACI Position Paper, in collaboration with EFA, highlights the most important research needs in the field of allergy to serve as key recommendations for future research funding at the national and European levels. Although allergies may involve almost every organ of the body and an array of diverse external factors act as triggers, there are several common themes that need to be prioritized in research efforts. As in many other chronic diseases, effective prevention, curative treatment and accurate, rapid diagnosis represent major unmet needs. Detailed phenotyping/endotyping stands out as widely required in order to arrange or re-categorize clinical syndromes into more coherent, uniform and
Published: 2012

24. Research needs in allergy:an EAACI position paper, in collaboration with EFA

Author: Papadopoulos, Nikolaos G, Agache, Ioana, Bavbek, Sevim, Bilo, Beatrice M, Braido, Fulvio, Cardona, Victoria, Custovic, Adnan, Demonchy, Jan, Demoly, Pascal, Eigenmann, Philippe, Gayraud, Jacques, Grattan, Clive, Heffler, Enrico, Hellings, Peter W, Jutel, Marek, Knol, Edward, Lötvall, Jan, Muraro, Antonella, Poulsen, Lars K., Roberts, Graham, Schmid-Grendelmeier, Peter, Skevaki, Chrysanthi, Triggiani, Massimo, Vanree, Ronald, Werfel, Thomas, Flood, Breda, Palkonen, Susanna, Savli, Roberta, Allegri, Pia, Annesi-Maesano, Isabella, Annunziato, Francesco, Antolin-Amerigo, Dario, Apfelbacher, Christian, Blanca, Miguel, Bogacka, Ewa, Bonadonna, Patrizia, Bonini, Matteo, Boyman, Onur, Brockow, Knut, Burney, Peter, Buters, Jeroen, Butiene, Indre, Calderon, Moises, Cardell, Lars Olaf, Caubet, Jean-Christoph, Celenk, Sevcan, Cichocka-Jarosz, Ewa, Cingi, Cemal, Couto, Mariana, Dejong, Nicolette, Del Giacco, Stefano, Douladiris, Nikolaos, Fassio, Filippo, Fauquert, Jean-Luc, Fernandez, Javier, Rivas, Montserrat Fernandez, Ferrer, Marta, Flohr, Carsten, Gardner, James, Genuneit, Jon, Gevaert, Philippe, Groblewska, Anna, Hamelmann, Eckard, Hoffmann, Hans Jürgen, Hoffmann-Sommergruber, Karin, Hovhannisyan, Lilit, Hox, Valérie, Jahnsen, Frode L, Kalayci, Omer, Kalpaklioglu, Ayse Füsun, Kleine-Tebbe, Jörg, Konstantinou, George, Kurowski, Marcin, Lau, Susanne, Lauener, Roger, Lauerma, Antti, Logan, Kirsty, Magnan, Antoine, Makowska, Joanna, Makrinioti, Heidi, Mangina, Paraskevi, Manole, Felicia, Mari, Adriano, Mazon, Angel, Mills, Clare, Mingomataj, Ervin C, Niggemann, Bodo, Nilsson, Gunnar, Ollert, Markus, O'Mahony, Liam, O'Neil, Serena, Pala, Gianni, Papi, Alberto, Passalacqua, Gianni, Perkin, Michael, Pfaar, Oliver, Pitsios, Constantinos, Quirce, Santiago, Raap, Ulrike, Raulf-Heimsoth, Monika, Rhyner, Claudio, Robson-Ansley, Paula, Alves, Rodrigo Rodrigues, Roje, Zeljka, Rondon, Carmen, Rudzeviciene, Odilija, Ruëff, Franziska, Rukhadze, Maia, Rumi, Gabriele, Sackesen, Cansin, Santos, Alexandra F, Santucci, Annalisa, Scharf, Christian, Schmidt-Weber, Carsten, Schnyder, Benno, Schwarze, Jürgen, Senna, Gianenrico, Sergejeva, Svetlana, Seys, Sven, Siracusa, Andrea, Skypala, Isabel, Sokolowska, Milena, Spertini, Francois, Spiewak, Radoslaw, Sprikkelman, Aline, Sturm, Gunter, Swoboda, Ines, Terreehorst, Ingrid, Toskala, Elina, Traidl-Hoffmann, Claudia, Venter, Carina, Vlieg-Boerstra, Berber, Whitacker, Paul, Worm, Margitta, Xepapadaki, Paraskevi, Akdis, Cezmi A, Papadopoulos, Nikolaos G, Agache, Ioana, Bavbek, Sevim, Bilo, Beatrice M, Braido, Fulvio, Cardona, Victoria, Custovic, Adnan, Demonchy, Jan, Demoly, Pascal, Eigenmann, Philippe, Gayraud, Jacques, Grattan, Clive, Heffler, Enrico, Hellings, Peter W, Jutel, Marek, Knol, Edward, Lötvall, Jan, Muraro, Antonella, Poulsen, Lars K., Roberts, Graham, Schmid-Grendelmeier, Peter, Skevaki, Chrysanthi, Triggiani, Massimo, Vanree, Ronald, Werfel, Thomas, Flood, Breda, Palkonen, Susanna, Savli, Roberta, Allegri, Pia, Annesi-Maesano, Isabella, Annunziato, Francesco, Antolin-Amerigo, Dario, Apfelbacher, Christian, Blanca, Miguel, Bogacka, Ewa, Bonadonna, Patrizia, Bonini, Matteo, Boyman, Onur, Brockow, Knut, Burney, Peter, Buters, Jeroen, Butiene, Indre, Calderon, Moises, Cardell, Lars Olaf, Caubet, Jean-Christoph, Celenk, Sevcan, Cichocka-Jarosz, Ewa, Cingi, Cemal, Couto, Mariana, Dejong, Nicolette, Del Giacco, Stefano, Douladiris, Nikolaos, Fassio, Filippo, Fauquert, Jean-Luc, Fernandez, Javier, Rivas, Montserrat Fernandez, Ferrer, Marta, Flohr, Carsten, Gardner, James, Genuneit, Jon, Gevaert, Philippe, Groblewska, Anna, Hamelmann, Eckard, Hoffmann, Hans Jürgen, Hoffmann-Sommergruber, Karin, Hovhannisyan, Lilit, Hox, Valérie, Jahnsen, Frode L, Kalayci, Omer, Kalpaklioglu, Ayse Füsun, Kleine-Tebbe, Jörg, Konstantinou, George, Kurowski, Marcin, Lau, Susanne, Lauener, Roger, Lauerma, Antti, Logan, Kirsty, Magnan, Antoine, Makowska, Joanna, Makrinioti, Heidi, Mangina, Paraskevi, Manole, Felicia, Mari, Adriano, Mazon, Angel, Mills, Clare, Mingomataj, Ervin C, Niggemann, Bodo, Nilsson, Gunnar, Ollert, Markus, O'Mahony, Liam, O'Neil, Serena, Pala, Gianni, Papi, Alberto, Passalacqua, Gianni, Perkin, Michael, Pfaar, Oliver, Pitsios, Constantinos, Quirce, Santiago, Raap, Ulrike, Raulf-Heimsoth, Monika, Rhyner, Claudio, Robson-Ansley, Paula, Alves, Rodrigo Rodrigues, Roje, Zeljka, Rondon, Carmen, Rudzeviciene, Odilija, Ruëff, Franziska, Rukhadze, Maia, Rumi, Gabriele, Sackesen, Cansin, Santos, Alexandra F, Santucci, Annalisa, Scharf, Christian, Schmidt-Weber, Carsten, Schnyder, Benno, Schwarze, Jürgen, Senna, Gianenrico, Sergejeva, Svetlana, Seys, Sven, Siracusa, Andrea, Skypala, Isabel, Sokolowska, Milena, Spertini, Francois, Spiewak, Radoslaw, Sprikkelman, Aline, Sturm, Gunter, Swoboda, Ines, Terreehorst, Ingrid, Toskala, Elina, Traidl-Hoffmann, Claudia, Venter, Carina, Vlieg-Boerstra, Berber, Whitacker, Paul, Worm, Margitta, Xepapadaki, Paraskevi, and Akdis, Cezmi A
Abstract: In less than half a century, allergy, originally perceived as a rare disease, has become a major public health threat, today affecting the lives of more than 60 million people in Europe, and probably close to one billion worldwide, thereby heavily impacting the budgets of public health systems. More disturbingly, its prevalence and impact are on the rise, a development that has been associated with environmental and lifestyle changes accompanying the continuous process of urbanization and globalization. Therefore, there is an urgent need to prioritize and concert research efforts in the field of allergy, in order to achieve sustainable results on prevention, diagnosis and treatment of this most prevalent chronic disease of the 21st century.The European Academy of Allergy and Clinical Immunology (EAACI) is the leading professional organization in the field of allergy, promoting excellence in clinical care, education, training and basic and translational research, all with the ultimate goal of improving the health of allergic patients. The European Federation of Allergy and Airways Diseases Patients' Associations (EFA) is a non-profit network of allergy, asthma and Chronic Obstructive Pulmonary Disorder (COPD) patients' organizations. In support of their missions, the present EAACI Position Paper, in collaboration with EFA, highlights the most important research needs in the field of allergy to serve as key recommendations for future research funding at the national and European levels.Although allergies may involve almost every organ of the body and an array of diverse external factors act as triggers, there are several common themes that need to be prioritized in research efforts. As in many other chronic diseases, effective prevention, curative treatment and accurate, rapid diagnosis represent major unmet needs. Detailed phenotyping/endotyping stands out as widely required in order to arrange or re-categorize clinical syndromes into more coherent, uniform
Published: 2012

25. Research needs in allergy:an EAACI position paper, in collaboration with EFA

Author: Papadopoulos, Nikolaos G, Agache, Ioana, Bavbek, Sevim, Bilo, Beatrice M, Braido, Fulvio, Cardona, Victoria, Custovic, Adnan, Demonchy, Jan, Demoly, Pascal, Eigenmann, Philippe, Gayraud, Jacques, Grattan, Clive, Heffler, Enrico, Hellings, Peter W, Jutel, Marek, Knol, Edward, Lötvall, Jan, Muraro, Antonella, Poulsen, Lars K., Roberts, Graham, Schmid-Grendelmeier, Peter, Skevaki, Chrysanthi, Triggiani, Massimo, Vanree, Ronald, Werfel, Thomas, Flood, Breda, Palkonen, Susanna, Savli, Roberta, Allegri, Pia, Annesi-Maesano, Isabella, Annunziato, Francesco, Antolin-Amerigo, Dario, Apfelbacher, Christian, Blanca, Miguel, Bogacka, Ewa, Bonadonna, Patrizia, Bonini, Matteo, Boyman, Onur, Brockow, Knut, Burney, Peter, Buters, Jeroen, Butiene, Indre, Calderon, Moises, Cardell, Lars Olaf, Caubet, Jean-Christoph, Celenk, Sevcan, Cichocka-Jarosz, Ewa, Cingi, Cemal, Couto, Mariana, Dejong, Nicolette, Del Giacco, Stefano, Douladiris, Nikolaos, Fassio, Filippo, Fauquert, Jean-Luc, Fernandez, Javier, Rivas, Montserrat Fernandez, Ferrer, Marta, Flohr, Carsten, Gardner, James, Genuneit, Jon, Gevaert, Philippe, Groblewska, Anna, Hamelmann, Eckard, Hoffmann, Hans Jürgen, Hoffmann-Sommergruber, Karin, Hovhannisyan, Lilit, Hox, Valérie, Jahnsen, Frode L, Kalayci, Omer, Kalpaklioglu, Ayse Füsun, Kleine-Tebbe, Jörg, Konstantinou, George, Kurowski, Marcin, Lau, Susanne, Lauener, Roger, Lauerma, Antti, Logan, Kirsty, Magnan, Antoine, Makowska, Joanna, Makrinioti, Heidi, Mangina, Paraskevi, Manole, Felicia, Mari, Adriano, Mazon, Angel, Mills, Clare, Mingomataj, Ervin C, Niggemann, Bodo, Nilsson, Gunnar, Ollert, Markus, O'Mahony, Liam, O'Neil, Serena, Pala, Gianni, Papi, Alberto, Passalacqua, Gianni, Perkin, Michael, Pfaar, Oliver, Pitsios, Constantinos, Quirce, Santiago, Raap, Ulrike, Raulf-Heimsoth, Monika, Rhyner, Claudio, Robson-Ansley, Paula, Alves, Rodrigo Rodrigues, Roje, Zeljka, Rondon, Carmen, Rudzeviciene, Odilija, Ruëff, Franziska, Rukhadze, Maia, Rumi, Gabriele, Sackesen, Cansin, Santos, Alexandra F, Santucci, Annalisa, Scharf, Christian, Schmidt-Weber, Carsten, Schnyder, Benno, Schwarze, Jürgen, Senna, Gianenrico, Sergejeva, Svetlana, Seys, Sven, Siracusa, Andrea, Skypala, Isabel, Sokolowska, Milena, Spertini, Francois, Spiewak, Radoslaw, Sprikkelman, Aline, Sturm, Gunter, Swoboda, Ines, Terreehorst, Ingrid, Toskala, Elina, Traidl-Hoffmann, Claudia, Venter, Carina, Vlieg-Boerstra, Berber, Whitacker, Paul, Worm, Margitta, Xepapadaki, Paraskevi, Akdis, Cezmi A, Papadopoulos, Nikolaos G, Agache, Ioana, Bavbek, Sevim, Bilo, Beatrice M, Braido, Fulvio, Cardona, Victoria, Custovic, Adnan, Demonchy, Jan, Demoly, Pascal, Eigenmann, Philippe, Gayraud, Jacques, Grattan, Clive, Heffler, Enrico, Hellings, Peter W, Jutel, Marek, Knol, Edward, Lötvall, Jan, Muraro, Antonella, Poulsen, Lars K., Roberts, Graham, Schmid-Grendelmeier, Peter, Skevaki, Chrysanthi, Triggiani, Massimo, Vanree, Ronald, Werfel, Thomas, Flood, Breda, Palkonen, Susanna, Savli, Roberta, Allegri, Pia, Annesi-Maesano, Isabella, Annunziato, Francesco, Antolin-Amerigo, Dario, Apfelbacher, Christian, Blanca, Miguel, Bogacka, Ewa, Bonadonna, Patrizia, Bonini, Matteo, Boyman, Onur, Brockow, Knut, Burney, Peter, Buters, Jeroen, Butiene, Indre, Calderon, Moises, Cardell, Lars Olaf, Caubet, Jean-Christoph, Celenk, Sevcan, Cichocka-Jarosz, Ewa, Cingi, Cemal, Couto, Mariana, Dejong, Nicolette, Del Giacco, Stefano, Douladiris, Nikolaos, Fassio, Filippo, Fauquert, Jean-Luc, Fernandez, Javier, Rivas, Montserrat Fernandez, Ferrer, Marta, Flohr, Carsten, Gardner, James, Genuneit, Jon, Gevaert, Philippe, Groblewska, Anna, Hamelmann, Eckard, Hoffmann, Hans Jürgen, Hoffmann-Sommergruber, Karin, Hovhannisyan, Lilit, Hox, Valérie, Jahnsen, Frode L, Kalayci, Omer, Kalpaklioglu, Ayse Füsun, Kleine-Tebbe, Jörg, Konstantinou, George, Kurowski, Marcin, Lau, Susanne, Lauener, Roger, Lauerma, Antti, Logan, Kirsty, Magnan, Antoine, Makowska, Joanna, Makrinioti, Heidi, Mangina, Paraskevi, Manole, Felicia, Mari, Adriano, Mazon, Angel, Mills, Clare, Mingomataj, Ervin C, Niggemann, Bodo, Nilsson, Gunnar, Ollert, Markus, O'Mahony, Liam, O'Neil, Serena, Pala, Gianni, Papi, Alberto, Passalacqua, Gianni, Perkin, Michael, Pfaar, Oliver, Pitsios, Constantinos, Quirce, Santiago, Raap, Ulrike, Raulf-Heimsoth, Monika, Rhyner, Claudio, Robson-Ansley, Paula, Alves, Rodrigo Rodrigues, Roje, Zeljka, Rondon, Carmen, Rudzeviciene, Odilija, Ruëff, Franziska, Rukhadze, Maia, Rumi, Gabriele, Sackesen, Cansin, Santos, Alexandra F, Santucci, Annalisa, Scharf, Christian, Schmidt-Weber, Carsten, Schnyder, Benno, Schwarze, Jürgen, Senna, Gianenrico, Sergejeva, Svetlana, Seys, Sven, Siracusa, Andrea, Skypala, Isabel, Sokolowska, Milena, Spertini, Francois, Spiewak, Radoslaw, Sprikkelman, Aline, Sturm, Gunter, Swoboda, Ines, Terreehorst, Ingrid, Toskala, Elina, Traidl-Hoffmann, Claudia, Venter, Carina, Vlieg-Boerstra, Berber, Whitacker, Paul, Worm, Margitta, Xepapadaki, Paraskevi, and Akdis, Cezmi A
Abstract: In less than half a century, allergy, originally perceived as a rare disease, has become a major public health threat, today affecting the lives of more than 60 million people in Europe, and probably close to one billion worldwide, thereby heavily impacting the budgets of public health systems. More disturbingly, its prevalence and impact are on the rise, a development that has been associated with environmental and lifestyle changes accompanying the continuous process of urbanization and globalization. Therefore, there is an urgent need to prioritize and concert research efforts in the field of allergy, in order to achieve sustainable results on prevention, diagnosis and treatment of this most prevalent chronic disease of the 21st century.The European Academy of Allergy and Clinical Immunology (EAACI) is the leading professional organization in the field of allergy, promoting excellence in clinical care, education, training and basic and translational research, all with the ultimate goal of improving the health of allergic patients. The European Federation of Allergy and Airways Diseases Patients' Associations (EFA) is a non-profit network of allergy, asthma and Chronic Obstructive Pulmonary Disorder (COPD) patients' organizations. In support of their missions, the present EAACI Position Paper, in collaboration with EFA, highlights the most important research needs in the field of allergy to serve as key recommendations for future research funding at the national and European levels.Although allergies may involve almost every organ of the body and an array of diverse external factors act as triggers, there are several common themes that need to be prioritized in research efforts. As in many other chronic diseases, effective prevention, curative treatment and accurate, rapid diagnosis represent major unmet needs. Detailed phenotyping/endotyping stands out as widely required in order to arrange or re-categorize clinical syndromes into more coherent, uniform
Published: 2012

26. MiR-155 is overexpressed in patients with atopic dermatitis and modulates T-cell proliferative responses by targeting cytotoxic T lymphocyte-associated antigen 4.

Author: Sonkoly, Enikö, Janson, Peter, Majuri, Marja-Leena, Savinko, Terhi, Fyhrquist, Nanna, Eidsmo, Liv, Xu, Ning, Meisgen, Florian, Wei, Tianling, Bradley, Maria, Stenvang, Jan, Kauppinen, Sakari, Alenius, Harri, Lauerma, Antti, Homey, Bernhard, Winqvist, Ola, Ståhle, Mona, Pivarcsi, Andor, Sonkoly, Enikö, Janson, Peter, Majuri, Marja-Leena, Savinko, Terhi, Fyhrquist, Nanna, Eidsmo, Liv, Xu, Ning, Meisgen, Florian, Wei, Tianling, Bradley, Maria, Stenvang, Jan, Kauppinen, Sakari, Alenius, Harri, Lauerma, Antti, Homey, Bernhard, Winqvist, Ola, Ståhle, Mona, and Pivarcsi, Andor
Abstract: BACKGROUND: MicroRNAs (miRNAs) are short noncoding RNAs that suppress gene expression at the posttranscriptional level. Atopic dermatitis is a common chronic inflammatory skin disease characterized by the presence of activated T cells within the skin. OBJECTIVE: We sought to explore the role of miRNAs in the pathogenesis of atopic dermatitis. METHODS: Global miRNA expression in healthy and lesional skin of patients with atopic dermatitis was compared by using TaqMan MicroRNA Low Density Arrays. miR-155 expression in tissues and cells was quantified by means of quantitative real-time PCR. The cellular localization of miR-155 was analyzed by means of in situ hybridization. The regulation of cytotoxic T lymphocyte-associated antigen (CTLA-4) by miR-155 was investigated by using luciferase reporter assays and flow cytometry. CTLA-4 expression and functional assays were performed on T(H) cells overexpressing miR-155. RESULTS: miR-155 was one of the highest-ranked upregulated miRNAs in patients with atopic dermatitis. In the skin miR-155 was predominantly expressed in infiltrating immune cells. miR-155 was upregulated during T-cell differentiation/activation and was markedly induced by T-cell activators in PBMCs in vitro and by superantigens and allergens in the skin in vivo. CTLA-4, an important negative regulator of T-cell activation, was identified as a direct target of miR-155. Overexpression of miR-155 in T(H) cells resulted in decreased CTLA-4 levels accompanied by an increased proliferative response. CONCLUSION: miR-155 is significantly overexpressed in patients with atopic dermatitis and might contribute to chronic skin inflammation by increasing the proliferative response of T(H) cells through the downregulation of CTLA-4.
Published: 2010
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27. IL-31 : a new link between T cells and pruritus in atopic skin inflammation.

Author: Sonkoly, Eniko, Muller, Anja, Lauerma, Antti I, Pivarcsi, Andor, Soto, Hortensia, Kemeny, Lajos, Alenius, Harri, Dieu-Nosjean, Marie-Caroline, Meller, Stephan, Rieker, Juliane, Steinhoff, Martin, Hoffmann, Thomas K, Ruzicka, Thomas, Zlotnik, Albert, Homey, Bernhard, Sonkoly, Eniko, Muller, Anja, Lauerma, Antti I, Pivarcsi, Andor, Soto, Hortensia, Kemeny, Lajos, Alenius, Harri, Dieu-Nosjean, Marie-Caroline, Meller, Stephan, Rieker, Juliane, Steinhoff, Martin, Hoffmann, Thomas K, Ruzicka, Thomas, Zlotnik, Albert, and Homey, Bernhard
Abstract: BACKGROUND: IL-31 is a novel T-cell-derived cytokine that induces severe pruritus and dermatitis in transgenic mice, and signals through a heterodimeric receptor composed of IL-31 receptor A and oncostatin M receptor. OBJECTIVE: To investigate the role of human IL-31 in pruritic and nonpruritic inflammatory skin diseases. METHODS: The expression of IL-31 was analyzed by quantitative real-time PCR in skin samples of healthy individuals and patients with chronic inflammatory skin diseases. Moreover, IL-31 expression was analyzed in nonlesional skin of atopic dermatitis patients after allergen or superantigen exposure, as well as in stimulated leukocytes. The tissue distribution of the IL-31 receptor heterodimer was investigated by DNA microarray analysis. RESULTS: IL-31 was significantly overexpressed in pruritic atopic compared with nonpruritic psoriatic skin inflammation. Highest IL-31 levels were detected in prurigo nodularis, one of the most pruritic forms of chronic skin inflammation. In vivo, staphylococcal superantigen rapidly induced IL-31 expression in atopic individuals. In vitro, staphylococcal enterotoxin B but not viruses or T(H)1 and T(H)2 cytokines induced IL-31 in leukocytes. In patients with atopic dermatitis, activated leukocytes expressed significantly higher IL-31 levels compared with control subjects. IL-31 receptor A showed most abundant expression in dorsal root ganglia representing the site where the cell bodies of cutaneous sensory neurons reside. CONCLUSION: Our findings provide a new link among staphylococcal colonization, subsequent T-cell recruitment/activation, and pruritus induction in patients with atopic dermatitis. Taken together, these findings show that IL-31 may represent a novel target for antipruritic drug development.
Published: 2006
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28. CCL1-CCR8 interactions : an axis mediating the recruitment of T cells and Langerhans-type dendritic cells to sites of atopic skin inflammation.

Author: Gombert, Michael, Dieu-Nosjean, Marie-Caroline, Winterberg, Franziska, Bünemann, Erich, Kubitza, Robert C, Da Cunha, Ludivine, Haahtela, Anna, Lehtimäki, Sari, Müller, Anja, Rieker, Juliane, Meller, Stephan, Pivarcsi, Andor, Koreck, Andrea, Fridman, Wolf-Herman, Zentgraf, Hans-Walter, Pavenstädt, Hermann, Amara, Ali, Caux, Christophe, Kemeny, Lajos, Alenius, Harri, Lauerma, Antti, Ruzicka, Thomas, Zlotnik, Albert, Homey, Bernhard, Gombert, Michael, Dieu-Nosjean, Marie-Caroline, Winterberg, Franziska, Bünemann, Erich, Kubitza, Robert C, Da Cunha, Ludivine, Haahtela, Anna, Lehtimäki, Sari, Müller, Anja, Rieker, Juliane, Meller, Stephan, Pivarcsi, Andor, Koreck, Andrea, Fridman, Wolf-Herman, Zentgraf, Hans-Walter, Pavenstädt, Hermann, Amara, Ali, Caux, Christophe, Kemeny, Lajos, Alenius, Harri, Lauerma, Antti, Ruzicka, Thomas, Zlotnik, Albert, and Homey, Bernhard
Abstract: Atopic dermatitis represents a chronically relapsing skin disease with a steadily increasing prevalence of 10-20% in children. Skin-infiltrating T cells, dendritic cells (DC), and mast cells are thought to play a crucial role in its pathogenesis. We report that the expression of the CC chemokine CCL1 (I-309) is significantly and selectively up-regulated in atopic dermatitis in comparison to psoriasis, cutaneous lupus erythematosus, or normal skin. CCL1 serum levels of atopic dermatitis patients are significantly higher than levels in healthy individuals. DC, mast cells, and dermal endothelial cells are abundant sources of CCL1 during atopic skin inflammation and allergen challenge, and Staphylococcus aureus-derived products induce its production. In vitro, binding and cross-linking of IgE on mast cells resulted in a significant up-regulation of this inflammatory chemokine. Its specific receptor, CCR8, is expressed on a small subset of circulating T cells and is abundantly expressed on interstitial DC, Langerhans cells generated in vitro, and their monocytic precursors. Although DC maintain their CCR8+ status during maturation, brief activation of circulating T cells recruits CCR8 from intracytoplamic stores to the cell surface. Moreover, the inflammatory and atopy-associated chemokine CCL1 synergizes with the homeostatic chemokine CXCL12 (SDF-1alpha) resulting in the recruitment of T cell and Langerhans cell-like DC. Taken together, these findings suggest that the axis CCL1-CCR8 links adaptive and innate immune functions that play a role in the initiation and amplification of atopic skin inflammation.
Published: 2005
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29. CC chemokine ligand 18, an atopic dermatitis-associated and dendritic cell-derived chemokine, is regulated by staphylococcal products and allergen exposure.

Author: Pivarcsi, Andor, Gombert, Michael, Dieu-Nosjean, Marie-Caroline, Lauerma, Antti, Kubitza, Robert, Meller, Stephan, Rieker, Juliane, Muller, Anja, Da Cunha, Ludivine, Haahtela, Anna, Sonkoly, Eniko, Fridman, Wolf-Herman, Alenius, Harri, Kemeny, Lajos, Ruzicka, Thomas, Zlotnik, Albert, Homey, Bernhard, Pivarcsi, Andor, Gombert, Michael, Dieu-Nosjean, Marie-Caroline, Lauerma, Antti, Kubitza, Robert, Meller, Stephan, Rieker, Juliane, Muller, Anja, Da Cunha, Ludivine, Haahtela, Anna, Sonkoly, Eniko, Fridman, Wolf-Herman, Alenius, Harri, Kemeny, Lajos, Ruzicka, Thomas, Zlotnik, Albert, and Homey, Bernhard
Abstract: Atopic dermatitis is a chronic inflammatory skin disease with a steadily increasing prevalence. Exposure to allergens or bacterial superantigens triggers T and dendritic cell (DC) recruitment and induces atopic skin inflammation. In this study, we report that among all known chemokines CCL18/DC-CK1/PARC represents the most highly expressed ligand in atopic dermatitis. Moreover, CCL18 expression is associated with an atopic dermatitis phenotype when compared with other chronic inflammatory skin diseases. DCs either dispersed within the dermis or clustering at sites showing perivascular infiltrates are abundant sources of CCL18. In vitro, microbial products including LPS, peptidoglycan, and mannan, as well as the T cell-derived activation signal CD40L, induced CCL18 in monocytes. In contrast to monocytes, monocyte-derived, interstitial-type, and Langerhans-type DCs showed a constitutive and abundant expression of CCL18. In comparison to Langerhans cells, interstitial-type DCs produced higher constitutive levels of CCL18. In vivo, topical exposure to the relevant allergen or the superantigen staphylococcal enterotoxin B, resulted in a significant induction of CCL18 in atopic dermatitis patients. Furthermore, in nonatopic NiSO4-sensitized individuals, only relevant allergen but not irritant exposure resulted in the induction of CCL18. Taken together, findings of the present study demonstrate that CCL18 is associated with an atopy/allergy skin phenotype, and is expressed at the interface between the environment and the host by cells constantly screening foreign Ags. Its regulation by allergen exposure and microbial products suggests an important role for CCL18 in the initiation and amplification of atopic skin inflammation.
Published: 2004
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29 results on '"Lauerma, Antti"'

1. The international EAACI/GA²LEN/EuroGuiDerm/APAAACI guideline for the definition, classification, diagnosis, and management of urticaria

2. The international EAACI/GA²LEN/EuroGuiDerm/APAAACI guideline for the definition, classification, diagnosis, and management of urticaria

3. Management of anaphylaxis due to COVID-19 vaccines in the elderly

4. ARIA‐EAACI care pathways for allergen immunotherapy in respiratory allergy

5. COVID-19 pandemic: Practical considerations on the organization of an allergy clinic-An EAACI/ARIA Position Paper.

6. COVID-19 pandemic:Practical considerations on the organization of an allergy clinic—An EAACI/ARIA Position Paper

7. The international EAACI/GA(2)LEN/EuroGuiDerm/APAAACI guideline for the definition, classification, diagnosis, and management of urticaria

8. Management of anaphylaxis due to COVID-19 vaccines in the elderly

9. COVID-19 pandemic:Practical considerations on the organization of an allergy clinic—An EAACI/ARIA Position Paper

10. Management of anaphylaxis due to COVID-19 vaccines in the elderly

11. COVID-19 pandemic and allergen immunotherapy - an EAACI survey

12. Machine-learning-driven biomarker discovery for the discrimination between allergic and irritant contact dermatitis

13. Machine-learning-driven biomarker discovery for the discrimination between allergic and irritant contact dermatitis

14. Machine-learning-driven biomarker discovery for the discrimination between allergic and irritant contact dermatitis

15. Machine-learning-driven biomarker discovery for the discrimination between allergic and irritant contact dermatitis

16. Machine-learning-driven biomarker discovery for the discrimination between allergic and irritant contact dermatitis

17. Skin Microbiome in Cutaneous T-Cell Lymphoma by 16S and Whole-Genome Shotgun Sequencing

18. Skin Microbiome in Cutaneous T-Cell Lymphoma by 16S and Whole-Genome Shotgun Sequencing

19. Machine-learning-driven biomarker discovery for the discrimination between allergic and irritant contact dermatitis

20. Skin Microbiome in Small- and Large-plaque Parapsoriasis

21. Research needs in allergy: an EAACI position paper, in collaboration with EFA

22. CD8+T Cell Migration to the Skin Requires CD4+Help in a Murine Model of Contact Hypersensitivity

23. Research needs in allergy:An EAACI position paper, in collaboration with EFA

24. Research needs in allergy:an EAACI position paper, in collaboration with EFA

25. Research needs in allergy:an EAACI position paper, in collaboration with EFA

26. MiR-155 is overexpressed in patients with atopic dermatitis and modulates T-cell proliferative responses by targeting cytotoxic T lymphocyte-associated antigen 4.

27. IL-31 : a new link between T cells and pruritus in atopic skin inflammation.

28. CCL1-CCR8 interactions : an axis mediating the recruitment of T cells and Langerhans-type dendritic cells to sites of atopic skin inflammation.

29. CC chemokine ligand 18, an atopic dermatitis-associated and dendritic cell-derived chemokine, is regulated by staphylococcal products and allergen exposure.

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29 results on '"Lauerma, Antti"'

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