70 results on '"Laprie, A."'
Search Results
2. Surface guided radiotherapy practice in paediatric oncology: a survey on behalf of the SIOPE radiation oncology working group
- Author
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Klinische Fysica RT, Cancer, MS Radiotherapie, Seravalli, Enrica, Kroon, Petra S, Bolle, Stephanie, Dunlea, Cathy, Harrabi, Semi B, Laprie, Anne, Lassen-Ramshad, Yasmin, Whitfield, Gillian, Janssens, Geert O, Klinische Fysica RT, Cancer, MS Radiotherapie, Seravalli, Enrica, Kroon, Petra S, Bolle, Stephanie, Dunlea, Cathy, Harrabi, Semi B, Laprie, Anne, Lassen-Ramshad, Yasmin, Whitfield, Gillian, and Janssens, Geert O
- Published
- 2024
3. Management of the vertebrae as an organ at risk in paediatric radiotherapy clinical trials: Initial QUARTET experience
- Author
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MS Radiotherapie, Cancer, Turcas, Andrada, Kelly, Sarah M., Bernier-Chastagner, Valérie, Bolle, Stephanie, Cameron, Alison, Corning, Coreen, Clementel, Enrico, Dieckmann, Karin, Davila Fajardo, Raquel, Gaze, Mark N., Laprie, Anne, Magelssen, Henriette, Meroni, Silvia, Pignoli, Emanuele, Safwat, Akmal, Scarzello, Giovanni, Talbot, James, Timmermann, Beate, Boterberg, Tom, Mandeville, Henry C., MS Radiotherapie, Cancer, Turcas, Andrada, Kelly, Sarah M., Bernier-Chastagner, Valérie, Bolle, Stephanie, Cameron, Alison, Corning, Coreen, Clementel, Enrico, Dieckmann, Karin, Davila Fajardo, Raquel, Gaze, Mark N., Laprie, Anne, Magelssen, Henriette, Meroni, Silvia, Pignoli, Emanuele, Safwat, Akmal, Scarzello, Giovanni, Talbot, James, Timmermann, Beate, Boterberg, Tom, and Mandeville, Henry C.
- Published
- 2023
4. Radical skeletal metastatic site irradiation in highrisk neuroblastoma: systematic review and proposal for a randomised trial: a report from the SIOPEN Radiotherapy Committee
- Author
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MS Radiotherapie, Cancer, Keshwani, Karimali, Boterberg, Tom, Dieckmann, Karin, Janssens, Geert O., Laprie, Anne, Timmermann, Beate, Gaze, Mark N., MS Radiotherapie, Cancer, Keshwani, Karimali, Boterberg, Tom, Dieckmann, Karin, Janssens, Geert O., Laprie, Anne, Timmermann, Beate, and Gaze, Mark N.
- Published
- 2023
5. Contemporary paediatric radiation oncology
- Author
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MS Radiotherapie, Boterberg, Tom, Dunlea, Cathy, Harrabi, Semi, Janssens, Geert, Laprie, Anne, Whitfield, Gillian, Gaze, Mark, MS Radiotherapie, Boterberg, Tom, Dunlea, Cathy, Harrabi, Semi, Janssens, Geert, Laprie, Anne, Whitfield, Gillian, and Gaze, Mark
- Published
- 2023
6. Quantitative Aspects of Designing and Validating Dependable Computing Systems -- Calculations, Measurements, and Simulations (Dagstuhl Seminar 9546)
- Author
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Echtle, Klaus, Laprie, Jean-Claude, Schneeweiss, Winfrid, Echtle, Klaus, Laprie, Jean-Claude, and Schneeweiss, Winfrid
- Published
- 2021
- Full Text
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7. Articulatory Copy Synthesis Based on the Speech Synthesizer VocalTractLab
- Author
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Birkholz, Peter, Möbius, Bernd, Laprie, Yves, Technische Universität Dresden, Gao, Yingming, Birkholz, Peter, Möbius, Bernd, Laprie, Yves, Technische Universität Dresden, and Gao, Yingming
- Abstract
Articulatory copy synthesis (ACS), a subarea of speech inversion, refers to the reproduction of natural utterances and involves both the physiological articulatory processes and their corresponding acoustic results. This thesis proposes two novel methods for the ACS of human speech using the articulatory speech synthesizer VocalTractLab (VTL) to address or mitigate the existing problems of speech inversion, such as non-unique mapping, acoustic variation among different speakers, and the time-consuming nature of the process. The first method involved finding appropriate VTL gestural scores for given natural utterances using a genetic algorithm. It consisted of two steps: gestural score initialization and optimization. In the first step, gestural scores were initialized using the given acoustic signals with speech recognition, grapheme-to-phoneme (G2P), and a VTL rule-based method for converting phoneme sequences to gestural scores. In the second step, the initial gestural scores were optimized by a genetic algorithm via an analysis-by-synthesis (ABS) procedure that sought to minimize the cosine distance between the acoustic features of the synthetic and natural utterances. The articulatory parameters were also regularized during the optimization process to restrict them to reasonable values. The second method was based on long short-term memory (LSTM) and convolutional neural networks, which were responsible for capturing the temporal dependence and the spatial structure of the acoustic features, respectively. The neural network regression models were trained, which used acoustic features as inputs and produced articulatory trajectories as outputs. In addition, to cover as much of the articulatory and acoustic space as possible, the training samples were augmented by manipulating the phonation type, speaking effort, and the vocal tract length of the synthetic utterances. Furthermore, two regularization methods were proposed: one based on the smoothness loss of articu
- Published
- 2021
8. Articulatory Copy Synthesis Based on the Speech Synthesizer VocalTractLab
- Author
-
Birkholz, Peter, Möbius, Bernd, Laprie, Yves, Technische Universität Dresden, Gao, Yingming, Birkholz, Peter, Möbius, Bernd, Laprie, Yves, Technische Universität Dresden, and Gao, Yingming
- Abstract
Articulatory copy synthesis (ACS), a subarea of speech inversion, refers to the reproduction of natural utterances and involves both the physiological articulatory processes and their corresponding acoustic results. This thesis proposes two novel methods for the ACS of human speech using the articulatory speech synthesizer VocalTractLab (VTL) to address or mitigate the existing problems of speech inversion, such as non-unique mapping, acoustic variation among different speakers, and the time-consuming nature of the process. The first method involved finding appropriate VTL gestural scores for given natural utterances using a genetic algorithm. It consisted of two steps: gestural score initialization and optimization. In the first step, gestural scores were initialized using the given acoustic signals with speech recognition, grapheme-to-phoneme (G2P), and a VTL rule-based method for converting phoneme sequences to gestural scores. In the second step, the initial gestural scores were optimized by a genetic algorithm via an analysis-by-synthesis (ABS) procedure that sought to minimize the cosine distance between the acoustic features of the synthetic and natural utterances. The articulatory parameters were also regularized during the optimization process to restrict them to reasonable values. The second method was based on long short-term memory (LSTM) and convolutional neural networks, which were responsible for capturing the temporal dependence and the spatial structure of the acoustic features, respectively. The neural network regression models were trained, which used acoustic features as inputs and produced articulatory trajectories as outputs. In addition, to cover as much of the articulatory and acoustic space as possible, the training samples were augmented by manipulating the phonation type, speaking effort, and the vocal tract length of the synthetic utterances. Furthermore, two regularization methods were proposed: one based on the smoothness loss of articu
- Published
- 2021
9. Articulatory Copy Synthesis Based on the Speech Synthesizer VocalTractLab
- Author
-
Birkholz, Peter, Möbius, Bernd, Laprie, Yves, Technische Universität Dresden, Gao, Yingming, Birkholz, Peter, Möbius, Bernd, Laprie, Yves, Technische Universität Dresden, and Gao, Yingming
- Abstract
Articulatory copy synthesis (ACS), a subarea of speech inversion, refers to the reproduction of natural utterances and involves both the physiological articulatory processes and their corresponding acoustic results. This thesis proposes two novel methods for the ACS of human speech using the articulatory speech synthesizer VocalTractLab (VTL) to address or mitigate the existing problems of speech inversion, such as non-unique mapping, acoustic variation among different speakers, and the time-consuming nature of the process. The first method involved finding appropriate VTL gestural scores for given natural utterances using a genetic algorithm. It consisted of two steps: gestural score initialization and optimization. In the first step, gestural scores were initialized using the given acoustic signals with speech recognition, grapheme-to-phoneme (G2P), and a VTL rule-based method for converting phoneme sequences to gestural scores. In the second step, the initial gestural scores were optimized by a genetic algorithm via an analysis-by-synthesis (ABS) procedure that sought to minimize the cosine distance between the acoustic features of the synthetic and natural utterances. The articulatory parameters were also regularized during the optimization process to restrict them to reasonable values. The second method was based on long short-term memory (LSTM) and convolutional neural networks, which were responsible for capturing the temporal dependence and the spatial structure of the acoustic features, respectively. The neural network regression models were trained, which used acoustic features as inputs and produced articulatory trajectories as outputs. In addition, to cover as much of the articulatory and acoustic space as possible, the training samples were augmented by manipulating the phonation type, speaking effort, and the vocal tract length of the synthetic utterances. Furthermore, two regularization methods were proposed: one based on the smoothness loss of articu
- Published
- 2021
10. Management of vertebral radiotherapy dose in paediatric patients with cancer: consensus recommendations from the SIOPE radiotherapy working group
- Author
-
Hoeben, B.A.W., Carrie, C., Timmermann, B., Mandeville, H.C., Gandola, L., Dieckmann, K., Albiac, M. Ramos, Magelssen, H., Lassen-Ramshad, Y., Ondrova, B., Ajithkumar, T., Alapetite, C., Balgobind, B.V., Bolle, S., Cameron, A.L., Fajardo, R. Davila, Dietzsch, S., Lecomte, D. Dumont, Heuvel-Eibrink, M.M. van den, Kortmann, R.D., Laprie, A., Melchior, P., Padovani, L., Rombi, B., Scarzello, G., Schwarz, R., Seiersen, K., Seravalli, E., Thorp, N., Whitfield, G.A., Boterberg, T., Janssens, G.O., Hoeben, B.A.W., Carrie, C., Timmermann, B., Mandeville, H.C., Gandola, L., Dieckmann, K., Albiac, M. Ramos, Magelssen, H., Lassen-Ramshad, Y., Ondrova, B., Ajithkumar, T., Alapetite, C., Balgobind, B.V., Bolle, S., Cameron, A.L., Fajardo, R. Davila, Dietzsch, S., Lecomte, D. Dumont, Heuvel-Eibrink, M.M. van den, Kortmann, R.D., Laprie, A., Melchior, P., Padovani, L., Rombi, B., Scarzello, G., Schwarz, R., Seiersen, K., Seravalli, E., Thorp, N., Whitfield, G.A., Boterberg, T., and Janssens, G.O.
- Abstract
Item does not contain fulltext, Inhomogeneities in radiotherapy dose distributions covering the vertebrae in children can produce long-term spinal problems, including kyphosis, lordosis, scoliosis, and hypoplasia. In the published literature, many often interrelated variables have been reported to affect the extent of potential radiotherapy damage to the spine. Articles published in the 2D and 3D radiotherapy era instructed radiation oncologists to avoid dose inhomogeneity over growing vertebrae. However, in the present era of highly conformal radiotherapy, steep dose gradients over at-risk structures can be generated and thus less harm is caused to patients. In this report, paediatric radiation oncologists from leading centres in 11 European countries have produced recommendations on how to approach dose coverage for target volumes that are adjacent to vertebrae to minimise the risk of long-term spinal problems. Based on available information, it is advised that homogeneous vertebral radiotherapy doses should be delivered in children who have not yet finished the pubertal growth spurt. If dose fall-off within vertebrae cannot be avoided, acceptable dose gradients for different age groups are detailed here. Vertebral delineation should include all primary ossification centres and growth plates, and therefore include at least the vertebral body and arch. For partial spinal radiotherapy, the number of irradiated vertebrae should be restricted as much as achievable, particularly at the thoracic level in young children (<6 years old). There is a need for multicentre research on vertebral radiotherapy dose distributions for children, but until more valid data become available, these recommendations can provide a basis for daily practice for radiation oncologists who have patients that require vertebral radiotherapy.
- Published
- 2019
11. Inter-observer variability in target delineation increases during adaptive treatment of head-and-neck and lung cancer
- Author
-
Apolle, R., Appold, S., Bijl, H.P., Blanchard, P., Bussink, J., Faivre-Finn, C., Khalifa, J., Laprie, A., Lievens, Y., Madani, I., Ruffier, A., Ruysscher, D. de, Elmpt, W. van, Troost, E.G.C., Apolle, R., Appold, S., Bijl, H.P., Blanchard, P., Bussink, J., Faivre-Finn, C., Khalifa, J., Laprie, A., Lievens, Y., Madani, I., Ruffier, A., Ruysscher, D. de, Elmpt, W. van, and Troost, E.G.C.
- Abstract
Item does not contain fulltext, Introduction: Inter-observer variability (IOV) in target volume delineation is a well-documented source of geometric uncertainty in radiotherapy. Such variability has not yet been explored in the context of adaptive re-delineation based on imaging data acquired during treatment. We compared IOV in the pre- and mid-treatment setting using expert primary gross tumour volume (GTV) and clinical target volume (CTV) delineations in locoregionally advanced head-and-neck squamous cell carcinoma (HNSCC) and (non-)small cell lung cancer [(N)SCLC]. Material and methods: Five and six observers participated in the HNSCC and (N)SCLC arm, respectively, and provided delineations for five cases each. Imaging data consisted of CT studies partly complemented by FDG-PET and was provided in two separate phases for pre- and mid-treatment. Global delineation compatibility was assessed with a volume overlap metric (the Generalised Conformity Index), while local extremes of IOV were identified through the standard deviation of surface distances from observer delineations to a median consensus delineation. Details of delineation procedures, in particular, GTV to CTV expansion and adaptation strategies, were collected through a questionnaire. Results: Volume overlap analysis revealed a worsening of IOV in all but one case per disease site, which failed to reach significance in this small sample (p-value range .063-.125). Changes in agreement were propagated from GTV to CTV delineations, but correlation could not be formally demonstrated. Surface distance based analysis identified longitudinal target extent as a pervasive source of disagreement for HNSCC. High variability in (N)SCLC was often associated with tumours abutting consolidated lung tissue or potentially invading the mediastinum. Adaptation practices were variable between observers with fewer than half stating that they consistently adapted pre-treatment delineations during treatment. Conclusion: IOV in target volume delineation incr
- Published
- 2019
12. Management of vertebral radiotherapy dose in paediatric patients with cancer : consensus recommendations from the SIOPE radiotherapy working group
- Author
-
Hoeben, Bianca A, Carrie, Christian, Timmermann, Beate, Mandeville, Henry C, Gandola, Lorenza, Dieckmann, Karin, Ramos Albiac, Monica, Magelssen, Henriette, Lassen-Ramshad, Yasmin, Ondrová, Barbora, Ajithkumar, Thankamma, Alapetite, Claire, Balgobind, Brian V, Bolle, Stephanie, Cameron, Alison L, Davila Fajardo, Raquel, Dietzsch, Stefan, Dumont Lecomte, Delphine, van den Heuvel-Eibrink, Marry M, Kortmann, Rolf D, Laprie, Anne, Melchior, Patrick, Padovani, Laetitia, Rombi, Barbara, Scarzello, Giovanni, Schwarz, Rudolf, Seiersen, Klaus, Seravalli, Enrica, Thorp, Nicola, Whitfield, Gillian A, Boterberg, Tom, Janssens, Geert O, Hoeben, Bianca A, Carrie, Christian, Timmermann, Beate, Mandeville, Henry C, Gandola, Lorenza, Dieckmann, Karin, Ramos Albiac, Monica, Magelssen, Henriette, Lassen-Ramshad, Yasmin, Ondrová, Barbora, Ajithkumar, Thankamma, Alapetite, Claire, Balgobind, Brian V, Bolle, Stephanie, Cameron, Alison L, Davila Fajardo, Raquel, Dietzsch, Stefan, Dumont Lecomte, Delphine, van den Heuvel-Eibrink, Marry M, Kortmann, Rolf D, Laprie, Anne, Melchior, Patrick, Padovani, Laetitia, Rombi, Barbara, Scarzello, Giovanni, Schwarz, Rudolf, Seiersen, Klaus, Seravalli, Enrica, Thorp, Nicola, Whitfield, Gillian A, Boterberg, Tom, and Janssens, Geert O
- Published
- 2019
13. Inter-observer variability in target delineation increases during adaptive treatment of head-and-neck and lung cancer
- Author
-
Apolle, Rudi, Apolle, Rudi, Appold, Steffen, Bijl, Henk P., Blanchard, Pierre, Bussink, Johan, Faivre-Finn, Corinne, Khalifa, Jonathan, Laprie, Anne, Lievens, Yolande, Madani, Indira, Ruffier, Amandine, de Ruysscher, Dirk, van Elmpt, Wouter, Troost, Esther G. C., Apolle, Rudi, Apolle, Rudi, Appold, Steffen, Bijl, Henk P., Blanchard, Pierre, Bussink, Johan, Faivre-Finn, Corinne, Khalifa, Jonathan, Laprie, Anne, Lievens, Yolande, Madani, Indira, Ruffier, Amandine, de Ruysscher, Dirk, van Elmpt, Wouter, and Troost, Esther G. C.
- Abstract
Introduction: Inter-observer variability (IOV) in target volume delineation is a well-documented source of geometric uncertainty in radiotherapy. Such variability has not yet been explored in the context of adaptive re-delineation based on imaging data acquired during treatment. We compared IOV in the pre- and mid-treatment setting using expert primary gross tumour volume (GTV) and clinical target volume (CTV) delineations in locoregionally advanced head-and-neck squamous cell carcinoma (HNSCC) and (non-)small cell lung cancer [(N)SCLC]. Material and methods: Five and six observers participated in the HNSCC and (N)SCLC arm, respectively, and provided delineations for five cases each. Imaging data consisted of CT studies partly complemented by FDG-PET and was provided in two separate phases for pre- and mid-treatment. Global delineation compatibility was assessed with a volume overlap metric (the Generalised Conformity Index), while local extremes of IOV were identified through the standard deviation of surface distances from observer delineations to a median consensus delineation. Details of delineation procedures, in particular, GTV to CTV expansion and adaptation strategies, were collected through a questionnaire. Results: Volume overlap analysis revealed a worsening of IOV in all but one case per disease site, which failed to reach significance in this small sample (p-value range .063-.125). Changes in agreement were propagated from GTV to CTV delineations, but correlation could not be formally demonstrated. Surface distance based analysis identified longitudinal target extent as a pervasive source of disagreement for HNSCC. High variability in (N)SCLC was often associated with tumours abutting consolidated lung tissue or potentially invading the mediastinum. Adaptation practices were variable between observers with fewer than half stating that they consistently adapted pre-treatment delineations during treatment. Conclusion: IOV in target volume delineation i
- Published
- 2019
14. Management of vertebral radiotherapy dose in paediatric patients with cancer : consensus recommendations from the SIOPE radiotherapy working group
- Author
-
Hoeben, Bianca A, Carrie, Christian, Timmermann, Beate, Mandeville, Henry C, Gandola, Lorenza, Dieckmann, Karin, Ramos Albiac, Monica, Magelssen, Henriette, Lassen-Ramshad, Yasmin, Ondrová, Barbora, Ajithkumar, Thankamma, Alapetite, Claire, Balgobind, Brian V, Bolle, Stephanie, Cameron, Alison L, Davila Fajardo, Raquel, Dietzsch, Stefan, Dumont Lecomte, Delphine, van den Heuvel-Eibrink, Marry M, Kortmann, Rolf D, Laprie, Anne, Melchior, Patrick, Padovani, Laetitia, Rombi, Barbara, Scarzello, Giovanni, Schwarz, Rudolf, Seiersen, Klaus, Seravalli, Enrica, Thorp, Nicola, Whitfield, Gillian A, Boterberg, Tom, Janssens, Geert O, Hoeben, Bianca A, Carrie, Christian, Timmermann, Beate, Mandeville, Henry C, Gandola, Lorenza, Dieckmann, Karin, Ramos Albiac, Monica, Magelssen, Henriette, Lassen-Ramshad, Yasmin, Ondrová, Barbora, Ajithkumar, Thankamma, Alapetite, Claire, Balgobind, Brian V, Bolle, Stephanie, Cameron, Alison L, Davila Fajardo, Raquel, Dietzsch, Stefan, Dumont Lecomte, Delphine, van den Heuvel-Eibrink, Marry M, Kortmann, Rolf D, Laprie, Anne, Melchior, Patrick, Padovani, Laetitia, Rombi, Barbara, Scarzello, Giovanni, Schwarz, Rudolf, Seiersen, Klaus, Seravalli, Enrica, Thorp, Nicola, Whitfield, Gillian A, Boterberg, Tom, and Janssens, Geert O
- Published
- 2019
15. Inter-observer variability in target delineation increases during adaptive treatment of head-and-neck and lung cancer
- Author
-
Apolle, R., Appold, S., Bijl, H.P., Blanchard, P., Bussink, J., Faivre-Finn, C., Khalifa, J., Laprie, A., Lievens, Y., Madani, I., Ruffier, A., Ruysscher, D. de, Elmpt, W. van, Troost, E.G.C., Apolle, R., Appold, S., Bijl, H.P., Blanchard, P., Bussink, J., Faivre-Finn, C., Khalifa, J., Laprie, A., Lievens, Y., Madani, I., Ruffier, A., Ruysscher, D. de, Elmpt, W. van, and Troost, E.G.C.
- Abstract
Item does not contain fulltext, Introduction: Inter-observer variability (IOV) in target volume delineation is a well-documented source of geometric uncertainty in radiotherapy. Such variability has not yet been explored in the context of adaptive re-delineation based on imaging data acquired during treatment. We compared IOV in the pre- and mid-treatment setting using expert primary gross tumour volume (GTV) and clinical target volume (CTV) delineations in locoregionally advanced head-and-neck squamous cell carcinoma (HNSCC) and (non-)small cell lung cancer [(N)SCLC]. Material and methods: Five and six observers participated in the HNSCC and (N)SCLC arm, respectively, and provided delineations for five cases each. Imaging data consisted of CT studies partly complemented by FDG-PET and was provided in two separate phases for pre- and mid-treatment. Global delineation compatibility was assessed with a volume overlap metric (the Generalised Conformity Index), while local extremes of IOV were identified through the standard deviation of surface distances from observer delineations to a median consensus delineation. Details of delineation procedures, in particular, GTV to CTV expansion and adaptation strategies, were collected through a questionnaire. Results: Volume overlap analysis revealed a worsening of IOV in all but one case per disease site, which failed to reach significance in this small sample (p-value range .063-.125). Changes in agreement were propagated from GTV to CTV delineations, but correlation could not be formally demonstrated. Surface distance based analysis identified longitudinal target extent as a pervasive source of disagreement for HNSCC. High variability in (N)SCLC was often associated with tumours abutting consolidated lung tissue or potentially invading the mediastinum. Adaptation practices were variable between observers with fewer than half stating that they consistently adapted pre-treatment delineations during treatment. Conclusion: IOV in target volume delineation incr
- Published
- 2019
16. Management of vertebral radiotherapy dose in paediatric patients with cancer: consensus recommendations from the SIOPE radiotherapy working group
- Author
-
Hoeben, B.A.W., Carrie, C., Timmermann, B., Mandeville, H.C., Gandola, L., Dieckmann, K., Albiac, M. Ramos, Magelssen, H., Lassen-Ramshad, Y., Ondrova, B., Ajithkumar, T., Alapetite, C., Balgobind, B.V., Bolle, S., Cameron, A.L., Fajardo, R. Davila, Dietzsch, S., Lecomte, D. Dumont, Heuvel-Eibrink, M.M. van den, Kortmann, R.D., Laprie, A., Melchior, P., Padovani, L., Rombi, B., Scarzello, G., Schwarz, R., Seiersen, K., Seravalli, E., Thorp, N., Whitfield, G.A., Boterberg, T., Janssens, G.O., Hoeben, B.A.W., Carrie, C., Timmermann, B., Mandeville, H.C., Gandola, L., Dieckmann, K., Albiac, M. Ramos, Magelssen, H., Lassen-Ramshad, Y., Ondrova, B., Ajithkumar, T., Alapetite, C., Balgobind, B.V., Bolle, S., Cameron, A.L., Fajardo, R. Davila, Dietzsch, S., Lecomte, D. Dumont, Heuvel-Eibrink, M.M. van den, Kortmann, R.D., Laprie, A., Melchior, P., Padovani, L., Rombi, B., Scarzello, G., Schwarz, R., Seiersen, K., Seravalli, E., Thorp, N., Whitfield, G.A., Boterberg, T., and Janssens, G.O.
- Abstract
Item does not contain fulltext, Inhomogeneities in radiotherapy dose distributions covering the vertebrae in children can produce long-term spinal problems, including kyphosis, lordosis, scoliosis, and hypoplasia. In the published literature, many often interrelated variables have been reported to affect the extent of potential radiotherapy damage to the spine. Articles published in the 2D and 3D radiotherapy era instructed radiation oncologists to avoid dose inhomogeneity over growing vertebrae. However, in the present era of highly conformal radiotherapy, steep dose gradients over at-risk structures can be generated and thus less harm is caused to patients. In this report, paediatric radiation oncologists from leading centres in 11 European countries have produced recommendations on how to approach dose coverage for target volumes that are adjacent to vertebrae to minimise the risk of long-term spinal problems. Based on available information, it is advised that homogeneous vertebral radiotherapy doses should be delivered in children who have not yet finished the pubertal growth spurt. If dose fall-off within vertebrae cannot be avoided, acceptable dose gradients for different age groups are detailed here. Vertebral delineation should include all primary ossification centres and growth plates, and therefore include at least the vertebral body and arch. For partial spinal radiotherapy, the number of irradiated vertebrae should be restricted as much as achievable, particularly at the thoracic level in young children (<6 years old). There is a need for multicentre research on vertebral radiotherapy dose distributions for children, but until more valid data become available, these recommendations can provide a basis for daily practice for radiation oncologists who have patients that require vertebral radiotherapy.
- Published
- 2019
17. Management of vertebral radiotherapy dose in paediatric patients with cancer : consensus recommendations from the SIOPE radiotherapy working group
- Author
-
Hoeben, Bianca A, Carrie, Christian, Timmermann, Beate, Mandeville, Henry C, Gandola, Lorenza, Dieckmann, Karin, Ramos Albiac, Monica, Magelssen, Henriette, Lassen-Ramshad, Yasmin, Ondrová, Barbora, Ajithkumar, Thankamma, Alapetite, Claire, Balgobind, Brian V, Bolle, Stephanie, Cameron, Alison L, Davila Fajardo, Raquel, Dietzsch, Stefan, Dumont Lecomte, Delphine, van den Heuvel-Eibrink, Marry M, Kortmann, Rolf D, Laprie, Anne, Melchior, Patrick, Padovani, Laetitia, Rombi, Barbara, Scarzello, Giovanni, Schwarz, Rudolf, Seiersen, Klaus, Seravalli, Enrica, Thorp, Nicola, Whitfield, Gillian A, Boterberg, Tom, Janssens, Geert O, Hoeben, Bianca A, Carrie, Christian, Timmermann, Beate, Mandeville, Henry C, Gandola, Lorenza, Dieckmann, Karin, Ramos Albiac, Monica, Magelssen, Henriette, Lassen-Ramshad, Yasmin, Ondrová, Barbora, Ajithkumar, Thankamma, Alapetite, Claire, Balgobind, Brian V, Bolle, Stephanie, Cameron, Alison L, Davila Fajardo, Raquel, Dietzsch, Stefan, Dumont Lecomte, Delphine, van den Heuvel-Eibrink, Marry M, Kortmann, Rolf D, Laprie, Anne, Melchior, Patrick, Padovani, Laetitia, Rombi, Barbara, Scarzello, Giovanni, Schwarz, Rudolf, Seiersen, Klaus, Seravalli, Enrica, Thorp, Nicola, Whitfield, Gillian A, Boterberg, Tom, and Janssens, Geert O
- Published
- 2019
18. Inter-observer variability in target delineation increases during adaptive treatment of head-and-neck and lung cancer
- Author
-
Apolle, R., Appold, S., Bijl, H.P., Blanchard, P., Bussink, J., Faivre-Finn, C., Khalifa, J., Laprie, A., Lievens, Y., Madani, I., Ruffier, A., Ruysscher, D. de, Elmpt, W. van, Troost, E.G.C., Apolle, R., Appold, S., Bijl, H.P., Blanchard, P., Bussink, J., Faivre-Finn, C., Khalifa, J., Laprie, A., Lievens, Y., Madani, I., Ruffier, A., Ruysscher, D. de, Elmpt, W. van, and Troost, E.G.C.
- Abstract
Item does not contain fulltext, Introduction: Inter-observer variability (IOV) in target volume delineation is a well-documented source of geometric uncertainty in radiotherapy. Such variability has not yet been explored in the context of adaptive re-delineation based on imaging data acquired during treatment. We compared IOV in the pre- and mid-treatment setting using expert primary gross tumour volume (GTV) and clinical target volume (CTV) delineations in locoregionally advanced head-and-neck squamous cell carcinoma (HNSCC) and (non-)small cell lung cancer [(N)SCLC]. Material and methods: Five and six observers participated in the HNSCC and (N)SCLC arm, respectively, and provided delineations for five cases each. Imaging data consisted of CT studies partly complemented by FDG-PET and was provided in two separate phases for pre- and mid-treatment. Global delineation compatibility was assessed with a volume overlap metric (the Generalised Conformity Index), while local extremes of IOV were identified through the standard deviation of surface distances from observer delineations to a median consensus delineation. Details of delineation procedures, in particular, GTV to CTV expansion and adaptation strategies, were collected through a questionnaire. Results: Volume overlap analysis revealed a worsening of IOV in all but one case per disease site, which failed to reach significance in this small sample (p-value range .063-.125). Changes in agreement were propagated from GTV to CTV delineations, but correlation could not be formally demonstrated. Surface distance based analysis identified longitudinal target extent as a pervasive source of disagreement for HNSCC. High variability in (N)SCLC was often associated with tumours abutting consolidated lung tissue or potentially invading the mediastinum. Adaptation practices were variable between observers with fewer than half stating that they consistently adapted pre-treatment delineations during treatment. Conclusion: IOV in target volume delineation incr
- Published
- 2019
19. Management of vertebral radiotherapy dose in paediatric patients with cancer: consensus recommendations from the SIOPE radiotherapy working group
- Author
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Hoeben, B.A.W., Carrie, C., Timmermann, B., Mandeville, H.C., Gandola, L., Dieckmann, K., Albiac, M. Ramos, Magelssen, H., Lassen-Ramshad, Y., Ondrova, B., Ajithkumar, T., Alapetite, C., Balgobind, B.V., Bolle, S., Cameron, A.L., Fajardo, R. Davila, Dietzsch, S., Lecomte, D. Dumont, Heuvel-Eibrink, M.M. van den, Kortmann, R.D., Laprie, A., Melchior, P., Padovani, L., Rombi, B., Scarzello, G., Schwarz, R., Seiersen, K., Seravalli, E., Thorp, N., Whitfield, G.A., Boterberg, T., Janssens, G.O., Hoeben, B.A.W., Carrie, C., Timmermann, B., Mandeville, H.C., Gandola, L., Dieckmann, K., Albiac, M. Ramos, Magelssen, H., Lassen-Ramshad, Y., Ondrova, B., Ajithkumar, T., Alapetite, C., Balgobind, B.V., Bolle, S., Cameron, A.L., Fajardo, R. Davila, Dietzsch, S., Lecomte, D. Dumont, Heuvel-Eibrink, M.M. van den, Kortmann, R.D., Laprie, A., Melchior, P., Padovani, L., Rombi, B., Scarzello, G., Schwarz, R., Seiersen, K., Seravalli, E., Thorp, N., Whitfield, G.A., Boterberg, T., and Janssens, G.O.
- Abstract
Item does not contain fulltext, Inhomogeneities in radiotherapy dose distributions covering the vertebrae in children can produce long-term spinal problems, including kyphosis, lordosis, scoliosis, and hypoplasia. In the published literature, many often interrelated variables have been reported to affect the extent of potential radiotherapy damage to the spine. Articles published in the 2D and 3D radiotherapy era instructed radiation oncologists to avoid dose inhomogeneity over growing vertebrae. However, in the present era of highly conformal radiotherapy, steep dose gradients over at-risk structures can be generated and thus less harm is caused to patients. In this report, paediatric radiation oncologists from leading centres in 11 European countries have produced recommendations on how to approach dose coverage for target volumes that are adjacent to vertebrae to minimise the risk of long-term spinal problems. Based on available information, it is advised that homogeneous vertebral radiotherapy doses should be delivered in children who have not yet finished the pubertal growth spurt. If dose fall-off within vertebrae cannot be avoided, acceptable dose gradients for different age groups are detailed here. Vertebral delineation should include all primary ossification centres and growth plates, and therefore include at least the vertebral body and arch. For partial spinal radiotherapy, the number of irradiated vertebrae should be restricted as much as achievable, particularly at the thoracic level in young children (<6 years old). There is a need for multicentre research on vertebral radiotherapy dose distributions for children, but until more valid data become available, these recommendations can provide a basis for daily practice for radiation oncologists who have patients that require vertebral radiotherapy.
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- 2019
20. Inter-observer variability in target delineation increases during adaptive treatment of head-and-neck and lung cancer
- Author
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Apolle, R., Appold, S., Bijl, H. P., Blanchard, P., Bussink, J., Faivre-Finn, C., Khalifa, J., Laprie, A., Lievens, Y., Madani, I., Ruffier, A., Ruysscher, D., Elmpt, W., Troost, E. G. C., Apolle, R., Appold, S., Bijl, H. P., Blanchard, P., Bussink, J., Faivre-Finn, C., Khalifa, J., Laprie, A., Lievens, Y., Madani, I., Ruffier, A., Ruysscher, D., Elmpt, W., and Troost, E. G. C.
- Abstract
Introduction Inter-observer variability (IOV) in target volume delineation is a well-documented source of geometric uncertainty in radiotherapy. Such variability has not yet been explored in the context of adaptive re-delineation based on imaging data acquired during treatment. We compared IOV in the pre- and mid-treatment setting using expert primary gross tumour volume (GTV) and clinical target volume (CTV) delineations in locoregionally advanced head-and-neck squamous cell carcinoma (HNSCC) and (non-)small cell lung cancer [(N)SCLC]. Materials and Methods Five and six observers participated in the HNSCC and (N)SCLC arm, respectively, and provided delineations for five cases each. Imaging data consisted of CT studies partly complemented by FDG-PET and was provided in two separate phases for pre- and mid-treatment. Global delineation compatibility was assessed with a volume overlap metric (the Generalised Conformity Index), while local extremes of IOV were identified through the standard deviation of surface distances from observer delineations to a median consensus delineation. Details of delineation procedures, in particular GTV to CTV expansion and adaptation strategies, were collected through a questionnaire. Results Volume overlap analysis revealed a worsening of IOV in all but one case per disease site, which failed to reach significance in this small sample (p-value range 0.063- 0.125). Changes in agreement were propagated from GTV to CTV delineations, but correlation could not be formally demonstrated. Surface distance based analysis identified longitudinal target extent as a pervasive source of disagreement for HNSCC. High variability in (N)SCLC was often associated with tumours abutting consolidated lung tissue or potentially invading the mediastinum. Adaptation practices were variable between observers with fewer than half stating that they consistently adapted pre-treatment delineations during treatment. Conclusion IOV in target volume delineation incre
- Published
- 2019
21. Inter-observer variability in target delineation increases during adaptive treatment of head-and-neck and lung cancer
- Author
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Apolle, R., Appold, S., Bijl, H. P., Blanchard, P., Bussink, J., Faivre-Finn, C., Khalifa, J., Laprie, A., Lievens, Y., Madani, I., Ruffier, A., Ruysscher, D., Elmpt, W., Troost, E. G. C., Apolle, R., Appold, S., Bijl, H. P., Blanchard, P., Bussink, J., Faivre-Finn, C., Khalifa, J., Laprie, A., Lievens, Y., Madani, I., Ruffier, A., Ruysscher, D., Elmpt, W., and Troost, E. G. C.
- Abstract
Introduction Inter-observer variability (IOV) in target volume delineation is a well-documented source of geometric uncertainty in radiotherapy. Such variability has not yet been explored in the context of adaptive re-delineation based on imaging data acquired during treatment. We compared IOV in the pre- and mid-treatment setting using expert primary gross tumour volume (GTV) and clinical target volume (CTV) delineations in locoregionally advanced head-and-neck squamous cell carcinoma (HNSCC) and (non-)small cell lung cancer [(N)SCLC]. Materials and Methods Five and six observers participated in the HNSCC and (N)SCLC arm, respectively, and provided delineations for five cases each. Imaging data consisted of CT studies partly complemented by FDG-PET and was provided in two separate phases for pre- and mid-treatment. Global delineation compatibility was assessed with a volume overlap metric (the Generalised Conformity Index), while local extremes of IOV were identified through the standard deviation of surface distances from observer delineations to a median consensus delineation. Details of delineation procedures, in particular GTV to CTV expansion and adaptation strategies, were collected through a questionnaire. Results Volume overlap analysis revealed a worsening of IOV in all but one case per disease site, which failed to reach significance in this small sample (p-value range 0.063- 0.125). Changes in agreement were propagated from GTV to CTV delineations, but correlation could not be formally demonstrated. Surface distance based analysis identified longitudinal target extent as a pervasive source of disagreement for HNSCC. High variability in (N)SCLC was often associated with tumours abutting consolidated lung tissue or potentially invading the mediastinum. Adaptation practices were variable between observers with fewer than half stating that they consistently adapted pre-treatment delineations during treatment. Conclusion IOV in target volume delineation incre
- Published
- 2019
22. Management of vertebral radiotherapy dose in paediatric patients with cancer: consensus recommendations from the SIOPE radiotherapy working group
- Author
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MS Radiotherapie, Cancer, Klinische Fysica RT, Hoeben, Bianca A, Carrie, Christian, Timmermann, Beate, Mandeville, Henry C, Gandola, Lorenza, Dieckmann, Karin, Ramos Albiac, Monica, Magelssen, Henriette, Lassen-Ramshad, Yasmin, Ondrová, Barbora, Ajithkumar, Thankamma, Alapetite, Claire, Balgobind, Brian V, Bolle, Stephanie, Cameron, Alison L, Davila Fajardo, Raquel, Dietzsch, Stefan, Dumont Lecomte, Delphine, van den Heuvel-Eibrink, Marry M, Kortmann, Rolf D, Laprie, Anne, Melchior, Patrick, Padovani, Laetitia, Rombi, Barbara, Scarzello, Giovanni, Schwarz, Rudolf, Seiersen, Klaus, Seravalli, Enrica, Thorp, Nicola, Whitfield, Gillian A, Boterberg, Tom, Janssens, Geert O, MS Radiotherapie, Cancer, Klinische Fysica RT, Hoeben, Bianca A, Carrie, Christian, Timmermann, Beate, Mandeville, Henry C, Gandola, Lorenza, Dieckmann, Karin, Ramos Albiac, Monica, Magelssen, Henriette, Lassen-Ramshad, Yasmin, Ondrová, Barbora, Ajithkumar, Thankamma, Alapetite, Claire, Balgobind, Brian V, Bolle, Stephanie, Cameron, Alison L, Davila Fajardo, Raquel, Dietzsch, Stefan, Dumont Lecomte, Delphine, van den Heuvel-Eibrink, Marry M, Kortmann, Rolf D, Laprie, Anne, Melchior, Patrick, Padovani, Laetitia, Rombi, Barbara, Scarzello, Giovanni, Schwarz, Rudolf, Seiersen, Klaus, Seravalli, Enrica, Thorp, Nicola, Whitfield, Gillian A, Boterberg, Tom, and Janssens, Geert O
- Published
- 2019
23. Inter-observer variability in target delineation increases during adaptive treatment of head-and-neck and lung cancer
- Author
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Apolle, Rudi, Appold, Steffen, Bijl, Henk P., Blanchard, Pierre, Bussink, Johan, Faivre-Finn, Corinne, Khalifa, Jonathan, Laprie, Anne, Lievens, Yolande, Madani, Indira, Ruffier, Amandine, de Ruysscher, Dirk, van Elmpt, Wouter, Troost, Esther G. C., Apolle, Rudi, Appold, Steffen, Bijl, Henk P., Blanchard, Pierre, Bussink, Johan, Faivre-Finn, Corinne, Khalifa, Jonathan, Laprie, Anne, Lievens, Yolande, Madani, Indira, Ruffier, Amandine, de Ruysscher, Dirk, van Elmpt, Wouter, and Troost, Esther G. C.
- Abstract
Introduction: Inter-observer variability (IOV) in target volume delineation is a well-documented source of geometric uncertainty in radiotherapy. Such variability has not yet been explored in the context of adaptive re-delineation based on imaging data acquired during treatment. We compared IOV in the pre- and mid-treatment setting using expert primary gross tumour volume (GTV) and clinical target volume (CTV) delineations in locoregionally advanced head-and-neck squamous cell carcinoma (HNSCC) and (non-)small cell lung cancer [(N)SCLC]. Material and methods: Five and six observers participated in the HNSCC and (N)SCLC arm, respectively, and provided delineations for five cases each. Imaging data consisted of CT studies partly complemented by FDG-PET and was provided in two separate phases for pre- and mid-treatment. Global delineation compatibility was assessed with a volume overlap metric (the Generalised Conformity Index), while local extremes of IOV were identified through the standard deviation of surface distances from observer delineations to a median consensus delineation. Details of delineation procedures, in particular, GTV to CTV expansion and adaptation strategies, were collected through a questionnaire. Results: Volume overlap analysis revealed a worsening of IOV in all but one case per disease site, which failed to reach significance in this small sample (p-value range .063-.125). Changes in agreement were propagated from GTV to CTV delineations, but correlation could not be formally demonstrated. Surface distance based analysis identified longitudinal target extent as a pervasive source of disagreement for HNSCC. High variability in (N)SCLC was often associated with tumours abutting consolidated lung tissue or potentially invading the mediastinum. Adaptation practices were variable between observers with fewer than half stating that they consistently adapted pre-treatment delineations during treatment. Conclusion: IOV in target volume delineation i
- Published
- 2019
24. EANO guidelines for the diagnosis and treatment of ependymal tumors
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Rudà, Roberta, Reifenberger, Guido, Frappaz, Didier, Pfister, Stefan M, Laprie, Anne, Santarius, Thomas, Roth, Patrick, Tonn, Joerg Christian, Soffietti, Riccardo, Weller, Michael, Rudà, Roberta, Reifenberger, Guido, Frappaz, Didier, Pfister, Stefan M, Laprie, Anne, Santarius, Thomas, Roth, Patrick, Tonn, Joerg Christian, Soffietti, Riccardo, and Weller, Michael
- Abstract
Ependymal tumors are rare CNS tumors and may occur at any age, but their proportion among primary brain tumors is highest in children and young adults. Thus, the level of evidence of diagnostic and therapeutic interventions is higher in the pediatric compared with the adult patient population.The diagnosis and disease staging is performed by craniospinal MRI. Tumor classification is achieved by histological and molecular diagnostic assessment of tissue specimens according to the World Health Organization (WHO) classification 2016. Surgery is the crucial initial treatment in both children and adults. In pediatric patients with intracranial ependymomas of WHO grades II or III, surgery is followed by local radiotherapy regardless of residual tumor volume. In adults, radiotherapy is employed in patients with anaplastic ependymoma WHO grade III, and in case of incomplete resection of WHO grade II ependymoma. Chemotherapy alone is reserved for young children <12 months and for adults with recurrent disease when further surgery and irradiation are no longer feasible. A gross total resection is the mainstay of treatment in spinal ependymomas, and radiotherapy is reserved for incompletely resected tumors. Nine subgroups of ependymal tumors across different anatomical compartments (supratentorial, posterior fossa, spinal) and patient ages have been identified with distinct genetic and epigenetic alterations, and with distinct outcomes. These findings may lead to more precise diagnostic and prognostic assessments, molecular subgroup-adapted therapies, and eventually new recommendations pending validation in prospective studies.
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- 2018
25. The influence of automation on tumor contouring
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Aselmaa, A. (author), van Herk, Marcel (author), Song, Y. (author), Goossens, R.H.M. (author), Laprie, Anne (author), Aselmaa, A. (author), van Herk, Marcel (author), Song, Y. (author), Goossens, R.H.M. (author), and Laprie, Anne (author)
- Abstract
Fully or semi-automatic contouring tools are increasingly being used in the tumor contouring task for radiotherapy. While the fully automatic contouring tools have not reached sufficient efficiency, the semi-automatic contouring tools balance more effectively between the human interaction and automation. This study evaluates the influences of a semi-automation contouring tool, called between-slice interpolation, on the resulting contours and the contouring process. The tumor contouring study was conducted on three patient cases with five physicians in a naturalistic setting. The contouring task consisted of initiating the 2D contour manually or with the interpolation tool and correcting that initial contour. The similarity of the resulting contours was pairwise measured within the manual or the interpolated category. Interactions with the software were recorded, and variations in the contouring workflows steps were compared. Results indicated that using the between-slice interpolation tool for creating the initial contour, instead of initiating it manually, influenced both the contouring process and outcomes. First, it was identified that contours initiated by the interpolation tool showed an increased similarity among themselves compared to the manually initiated contours. At the same time, influences to the resulting contours were below clinical relevance, and toward the desired direction—improved consistency of contours. Second, when interpolation was used, in two cases out of three, the average contouring time also decreased significantly. Therefore, the use of such an automation tool can be encouraged., Mechatronic Design, Industrial Design
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- 2017
- Full Text
- View/download PDF
26. Using a contextualized sensemaking model for interaction design: A case study of tumor contouring
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Aselmaa, A. (author), van Herk, Marcel (author), Laprie, Anne (author), Nestle, Ursula (author), Götz, Irina (author), Wiedenmann, Nicole (author), Schimek-Jasch, Tanja (author), Picaud, Francois (author), Syrykh, Charlotte (author), Cagetti, Leonel (author), Jolnerovski, Maria (author), Song, Y. (author), Goossens, R.H.M. (author), Aselmaa, A. (author), van Herk, Marcel (author), Laprie, Anne (author), Nestle, Ursula (author), Götz, Irina (author), Wiedenmann, Nicole (author), Schimek-Jasch, Tanja (author), Picaud, Francois (author), Syrykh, Charlotte (author), Cagetti, Leonel (author), Jolnerovski, Maria (author), Song, Y. (author), and Goossens, R.H.M. (author)
- Abstract
Sensemaking theories help designers understand the cognitive processes of a user when he/she performs a complicated task. This paper introduces a two-step approach of incorporating sensemaking support within the design of health information systems by: (1) modeling the sensemaking process of physicians while performing a task, and (2) identifying software interaction design requirements that support sensemaking based on this model. The two-step approach is presented based on a case study of the tumor contouring clinical task for radiotherapy planning. In the first step of the approach, a contextualized sensemaking model was developed to describe the sensemaking process based on the goal, the workflow and the context of the task. In the second step, based on a research software prototype, an experiment was conducted where three contouring tasks were performed by eight physicians respectively. Four types of navigation interactions and five types of interaction sequence patterns were identified by analyzing the gathered interaction log data from those twenty-four cases. Further in-depth study on each of the navigation interactions and interaction sequence patterns in relation to the contextualized sensemaking model revealed five main areas for design improvements to increase sensemaking support. Outcomes of the case study indicate that the proposed two-step approach was beneficial for gaining a deeper understanding of the sensemaking process during the task, as well as for identifying design requirements for better sensemaking support., Mechatronic Design, Industrial Design
- Published
- 2017
- Full Text
- View/download PDF
27. The influence of automation on tumor contouring
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Aselmaa, A. (author), van Herk, Marcel (author), Song, Y. (author), Goossens, R.H.M. (author), Laprie, Anne (author), Aselmaa, A. (author), van Herk, Marcel (author), Song, Y. (author), Goossens, R.H.M. (author), and Laprie, Anne (author)
- Abstract
Fully or semi-automatic contouring tools are increasingly being used in the tumor contouring task for radiotherapy. While the fully automatic contouring tools have not reached sufficient efficiency, the semi-automatic contouring tools balance more effectively between the human interaction and automation. This study evaluates the influences of a semi-automation contouring tool, called between-slice interpolation, on the resulting contours and the contouring process. The tumor contouring study was conducted on three patient cases with five physicians in a naturalistic setting. The contouring task consisted of initiating the 2D contour manually or with the interpolation tool and correcting that initial contour. The similarity of the resulting contours was pairwise measured within the manual or the interpolated category. Interactions with the software were recorded, and variations in the contouring workflows steps were compared. Results indicated that using the between-slice interpolation tool for creating the initial contour, instead of initiating it manually, influenced both the contouring process and outcomes. First, it was identified that contours initiated by the interpolation tool showed an increased similarity among themselves compared to the manually initiated contours. At the same time, influences to the resulting contours were below clinical relevance, and toward the desired direction—improved consistency of contours. Second, when interpolation was used, in two cases out of three, the average contouring time also decreased significantly. Therefore, the use of such an automation tool can be encouraged., Mechatronic Design, Industrial Design
- Published
- 2017
- Full Text
- View/download PDF
28. Using a contextualized sensemaking model for interaction design: A case study of tumor contouring
- Author
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Aselmaa, A. (author), van Herk, Marcel (author), Laprie, Anne (author), Nestle, Ursula (author), Götz, Irina (author), Wiedenmann, Nicole (author), Schimek-Jasch, Tanja (author), Picaud, Francois (author), Syrykh, Charlotte (author), Cagetti, Leonel (author), Jolnerovski, Maria (author), Song, Y. (author), Goossens, R.H.M. (author), Aselmaa, A. (author), van Herk, Marcel (author), Laprie, Anne (author), Nestle, Ursula (author), Götz, Irina (author), Wiedenmann, Nicole (author), Schimek-Jasch, Tanja (author), Picaud, Francois (author), Syrykh, Charlotte (author), Cagetti, Leonel (author), Jolnerovski, Maria (author), Song, Y. (author), and Goossens, R.H.M. (author)
- Abstract
Sensemaking theories help designers understand the cognitive processes of a user when he/she performs a complicated task. This paper introduces a two-step approach of incorporating sensemaking support within the design of health information systems by: (1) modeling the sensemaking process of physicians while performing a task, and (2) identifying software interaction design requirements that support sensemaking based on this model. The two-step approach is presented based on a case study of the tumor contouring clinical task for radiotherapy planning. In the first step of the approach, a contextualized sensemaking model was developed to describe the sensemaking process based on the goal, the workflow and the context of the task. In the second step, based on a research software prototype, an experiment was conducted where three contouring tasks were performed by eight physicians respectively. Four types of navigation interactions and five types of interaction sequence patterns were identified by analyzing the gathered interaction log data from those twenty-four cases. Further in-depth study on each of the navigation interactions and interaction sequence patterns in relation to the contextualized sensemaking model revealed five main areas for design improvements to increase sensemaking support. Outcomes of the case study indicate that the proposed two-step approach was beneficial for gaining a deeper understanding of the sensemaking process during the task, as well as for identifying design requirements for better sensemaking support., Mechatronic Design, Industrial Design
- Published
- 2017
- Full Text
- View/download PDF
29. Langzeittoxizität nach Strahlentherapie des lokalisierten Neuroblastoms im Kindesalter: Ergebnisse der NB90- und NB94-Studien
- Author
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Ducassou, Anne, Helfre, Sylvie, Bolle, Stéphanie, Leseur, Julie, Huchet, Aymeri, Rubie, Hervé, Valteau-Couanet, Dominique, Schleiermacher, Gudrun, Coze, Carole, Defachelles, Anne Sophie, Marabelle, Aurélien, Gambart, Marion, Ducassou, Stéphane, Devalck, Christine, Gandemer, Virginie, Munzer, Martine, Laprie, Anne, Munzer, Caroline, Padovani, Laetitia, Carrie, Christian, Haas-Kogan, Daphne, Bernier-Chastagner, Valérie, Demoor, Charlotte, Claude, Line, Ducassou, Anne, Helfre, Sylvie, Bolle, Stéphanie, Leseur, Julie, Huchet, Aymeri, Rubie, Hervé, Valteau-Couanet, Dominique, Schleiermacher, Gudrun, Coze, Carole, Defachelles, Anne Sophie, Marabelle, Aurélien, Gambart, Marion, Ducassou, Stéphane, Devalck, Christine, Gandemer, Virginie, Munzer, Martine, Laprie, Anne, Munzer, Caroline, Padovani, Laetitia, Carrie, Christian, Haas-Kogan, Daphne, Bernier-Chastagner, Valérie, Demoor, Charlotte, and Claude, Line
- Abstract
Introduction: Neuroblastoma (NB) is the most frequent indication for extracranial pediatric radiotherapy. As long-term survival of high-risk localized NB has greatly improved, we reviewed treatment-related late toxicities in pediatric patients who received postoperative radiotherapy (RT) for localized NB within two French prospective clinical trials: NB90 and NB94. Patients and methods: From 1990–2000, 610 children were enrolled. Among these, 35 were treated with induction chemotherapy, surgery, and RT. The recommended RT dose was 24 Gy at ≤ 2 years, 34 Gy at > 2 years, ± a 5 Gy boost in both age groups. Results: The 22 patients still alive after 5 years were analyzed. The median follow-up time was 14 years (range 5–21 years). Late effects after therapy occurred in 73 % of patients (16/22), within the RT field for 50 % (11/22). The most frequent in-field effects were musculoskeletal abnormalities (n = 7) that occurred only with doses > 31 Gy/1.5 Gy fraction (p = 0.037). Other effects were endocrine in 3 patients and second malignancies in 2 patients. Four patients presented with multiple in-field late effects only with doses > 31 Gy. Conclusion: After a median follow-up of 14 years, late effects with multimodality treatment were frequent. The most frequent effects were musculoskeletal abnormalities and the threshold for their occurrence was 31 Gy., SCOPUS: ar.j, info:eu-repo/semantics/published
- Published
- 2015
30. Langzeittoxizität nach Strahlentherapie des lokalisierten Neuroblastoms im Kindesalter: Ergebnisse der NB90- und NB94-Studien
- Author
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Ducassou, Anne, Helfre, Sylvie, Bolle, Stéphanie, Leseur, Julie, Huchet, Aymeri, Rubie, Hervé, Valteau-Couanet, Dominique, Schleiermacher, Gudrun, Coze, Carole, Defachelles, Anne Sophie, Marabelle, Aurélien, Gambart, Marion, Ducassou, Stéphane, Devalck, Christine, Gandemer, Virginie, Munzer, Martine, Laprie, Anne, Munzer, Caroline, Padovani, Laetitia, Carrie, Christian, Haas-Kogan, Daphne, Bernier-Chastagner, Valérie, Demoor, Charlotte, Claude, Line, Ducassou, Anne, Helfre, Sylvie, Bolle, Stéphanie, Leseur, Julie, Huchet, Aymeri, Rubie, Hervé, Valteau-Couanet, Dominique, Schleiermacher, Gudrun, Coze, Carole, Defachelles, Anne Sophie, Marabelle, Aurélien, Gambart, Marion, Ducassou, Stéphane, Devalck, Christine, Gandemer, Virginie, Munzer, Martine, Laprie, Anne, Munzer, Caroline, Padovani, Laetitia, Carrie, Christian, Haas-Kogan, Daphne, Bernier-Chastagner, Valérie, Demoor, Charlotte, and Claude, Line
- Abstract
Introduction: Neuroblastoma (NB) is the most frequent indication for extracranial pediatric radiotherapy. As long-term survival of high-risk localized NB has greatly improved, we reviewed treatment-related late toxicities in pediatric patients who received postoperative radiotherapy (RT) for localized NB within two French prospective clinical trials: NB90 and NB94. Patients and methods: From 1990–2000, 610 children were enrolled. Among these, 35 were treated with induction chemotherapy, surgery, and RT. The recommended RT dose was 24 Gy at ≤ 2 years, 34 Gy at > 2 years, ± a 5 Gy boost in both age groups. Results: The 22 patients still alive after 5 years were analyzed. The median follow-up time was 14 years (range 5–21 years). Late effects after therapy occurred in 73 % of patients (16/22), within the RT field for 50 % (11/22). The most frequent in-field effects were musculoskeletal abnormalities (n = 7) that occurred only with doses > 31 Gy/1.5 Gy fraction (p = 0.037). Other effects were endocrine in 3 patients and second malignancies in 2 patients. Four patients presented with multiple in-field late effects only with doses > 31 Gy. Conclusion: After a median follow-up of 14 years, late effects with multimodality treatment were frequent. The most frequent effects were musculoskeletal abnormalities and the threshold for their occurrence was 31 Gy., SCOPUS: ar.j, info:eu-repo/semantics/published
- Published
- 2015
31. Quantitative Aspects of Designing and Validating Dependable Computing Systems -- Calculations, Measurements, and Simulations (Dagstuhl Seminar 9546)
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Klaus Echtle and Winfried Görke and Jean-Claude Laprie and Winfrid Schneeweiss, Echtle, Klaus, Görke, Winfried, Laprie, Jean-Claude, Schneeweiss, Winfrid, Klaus Echtle and Winfried Görke and Jean-Claude Laprie and Winfrid Schneeweiss, Echtle, Klaus, Görke, Winfried, Laprie, Jean-Claude, and Schneeweiss, Winfrid
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- 1996
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32. Workflow analysis report
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Aselmaa, A. (author), Goossens, R.H.M. (author), Laprie, A. (author), Ken, S. (author), Fechter, T. (author), Ramkumar, A. (author), Freudenthal, A. (author), Aselmaa, A. (author), Goossens, R.H.M. (author), Laprie, A. (author), Ken, S. (author), Fechter, T. (author), Ramkumar, A. (author), and Freudenthal, A. (author)
- Abstract
Design Engineering, Industrial Design Engineering
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- 2013
33. Workflow analysis report
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Aselmaa, A. (author), Goossens, R.H.M. (author), Laprie, A. (author), Ken, S. (author), Fechter, T. (author), Ramkumar, A. (author), Freudenthal, A. (author), Aselmaa, A. (author), Goossens, R.H.M. (author), Laprie, A. (author), Ken, S. (author), Fechter, T. (author), Ramkumar, A. (author), and Freudenthal, A. (author)
- Abstract
Design Engineering, Industrial Design Engineering
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- 2013
34. Project no. 2005-021324 ASPI Audiovisual to Articulatory Speech Inversion: Deliverable D6.2 Final report on evaluation results
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Berger, Marie-Odile, Laprie, Yves, Maragos, Petros, Schoentgen, Jean, Engwall, Olov, Ananthakrishnan, G., Neiberg, D., Berger, Marie-Odile, Laprie, Yves, Maragos, Petros, Schoentgen, Jean, Engwall, Olov, Ananthakrishnan, G., and Neiberg, D.
- Abstract
info:eu-repo/semantics/published
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- 2009
35. ASPI Audiovisual to Articulatory Speech Inversion
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Maragos, Petros, Engwall, Olov, Laprie, Yves, Maeda, Shinji, Schoentgen, Jean, Katsamanis, A., Roussos, A., Maragos, Petros, Engwall, Olov, Laprie, Yves, Maeda, Shinji, Schoentgen, Jean, Katsamanis, A., and Roussos, A.
- Abstract
Deliverable D2.2 - Final Report on Speech Inversion Methods, FP6/IST-2005-021324 ASPI, info:eu-repo/semantics/published
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- 2009
36. ASPI Audiovisual to Articulatory Speech Inversion
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Berger, Marie-Odile, Laprie, Yves, Maragos, Petros, Schoentgen, Jean, Engwall, Olov, Ananthakrishnan, G., Neiberg, D., Berger, Marie-Odile, Laprie, Yves, Maragos, Petros, Schoentgen, Jean, Engwall, Olov, Ananthakrishnan, G., and Neiberg, D.
- Abstract
2005-021324, info:eu-repo/semantics/published
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- 2009
37. ASPI Audiovisual to Articulatory Speech Inversion
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Schoentgen, Jean, Aron, Michael, Engwall, Olov, Laprie, Yves, Maragos, Petros, Schoentgen, Jean, Aron, Michael, Engwall, Olov, Laprie, Yves, and Maragos, Petros
- Abstract
Deliverable D5.3 Final report on the development of evaluation protocols, 2005-021324, info:eu-repo/semantics/published
- Published
- 2009
38. Project no. 2005-021324 ASPI Audiovisual to Articulatory Speech Inversion: Deliverable D6.2 Final report on evaluation results
- Author
-
Berger, Marie-Odile, Laprie, Yves, Maragos, Petros, Schoentgen, Jean, Engwall, Olov, Ananthakrishnan, G., Neiberg, D., Berger, Marie-Odile, Laprie, Yves, Maragos, Petros, Schoentgen, Jean, Engwall, Olov, Ananthakrishnan, G., and Neiberg, D.
- Abstract
info:eu-repo/semantics/published
- Published
- 2009
39. ASPI Audiovisual to Articulatory Speech Inversion
- Author
-
Maragos, Petros, Engwall, Olov, Laprie, Yves, Maeda, Shinji, Schoentgen, Jean, Katsamanis, A., Roussos, A., Maragos, Petros, Engwall, Olov, Laprie, Yves, Maeda, Shinji, Schoentgen, Jean, Katsamanis, A., and Roussos, A.
- Abstract
Deliverable D2.2 - Final Report on Speech Inversion Methods, FP6/IST-2005-021324 ASPI, info:eu-repo/semantics/published
- Published
- 2009
40. ASPI Audiovisual to Articulatory Speech Inversion
- Author
-
Schoentgen, Jean, Aron, Michael, Engwall, Olov, Laprie, Yves, Maragos, Petros, Schoentgen, Jean, Aron, Michael, Engwall, Olov, Laprie, Yves, and Maragos, Petros
- Abstract
Deliverable D5.3 Final report on the development of evaluation protocols, 2005-021324, info:eu-repo/semantics/published
- Published
- 2009
41. ASPI Audiovisual to Articulatory Speech Inversion
- Author
-
Berger, Marie-Odile, Laprie, Yves, Maragos, Petros, Schoentgen, Jean, Engwall, Olov, Ananthakrishnan, G., Neiberg, D., Berger, Marie-Odile, Laprie, Yves, Maragos, Petros, Schoentgen, Jean, Engwall, Olov, Ananthakrishnan, G., and Neiberg, D.
- Abstract
2005-021324, info:eu-repo/semantics/published
- Published
- 2009
42. ASPI Audiovisual to Articulatory Speech Inversion
- Author
-
Laprie, Yves, Maragos, Petros, Schoentgen, Jean, Laprie, Yves, Maragos, Petros, and Schoentgen, Jean
- Abstract
Deliverable D6.1 Initial report on evaluation results, 2005-021324, info:eu-repo/semantics/published
- Published
- 2008
43. ASPI Audiovisual to Articulatory Speech Inversion
- Author
-
Aron, Michael, Laprie, Yves, Maragos, Petros, Schoentgen, Jean, Aron, Michael, Laprie, Yves, Maragos, Petros, and Schoentgen, Jean
- Abstract
Deliverable D5.2 :Interim report on the development of evaluation protocols, 2005-021324, info:eu-repo/semantics/published
- Published
- 2008
44. ASPI Audiovisual to Articulatory Speech Inversion
- Author
-
Aron, Michael, Laprie, Yves, Maragos, Petros, Schoentgen, Jean, Aron, Michael, Laprie, Yves, Maragos, Petros, and Schoentgen, Jean
- Abstract
Deliverable D5.2 :Interim report on the development of evaluation protocols, 2005-021324, info:eu-repo/semantics/published
- Published
- 2008
45. ASPI Audiovisual to Articulatory Speech Inversion
- Author
-
Laprie, Yves, Maragos, Petros, Schoentgen, Jean, Laprie, Yves, Maragos, Petros, and Schoentgen, Jean
- Abstract
Deliverable D6.1 Initial report on evaluation results, 2005-021324, info:eu-repo/semantics/published
- Published
- 2008
46. How can acoustic-to-articulatory maps be constrained ?
- Author
-
Laprie, Yves, Maragos, Petros, Schoentgen, Jean, Laprie, Yves, Maragos, Petros, and Schoentgen, Jean
- Abstract
5 pages (unpaginated DVD), info:eu-repo/semantics/published
- Published
- 2008
47. Modelling interdependencies between the electricity and information infrastructures
- Author
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Laprie, Jean-Claude, Kanoun, Karama, Kaaniche, Mohamed, Laprie, Jean-Claude, Kanoun, Karama, and Kaaniche, Mohamed
- Abstract
The aim of this paper is to provide qualitative models characterizing interdependencies related failures of two critical infrastructures: the electricity infrastructure and the associated information infrastructure. The interdependencies of these two infrastructures are increasing due to a growing connection of the power grid networks to the global information infrastructure, as a consequence of market deregulation and opening. These interdependencies increase the risk of failures. We focus on cascading, escalating and common-cause failures, which correspond to the main causes of failures due to interdependencies. We address failures in the electricity infrastructure, in combination with accidental failures in the information infrastructure, then we show briefly how malicious attacks in the information infrastructure can be addressed.
- Published
- 2008
48. Technology inventory and specification of fields investigated, ASPI, FET
- Author
-
Maeda, Shinji, Berger, Marie-Odile, Engwall, Olov, Laprie, Yves, Maragos, Petros, Potard, Blaise, Schoentgen, Jean, Maeda, Shinji, Berger, Marie-Odile, Engwall, Olov, Laprie, Yves, Maragos, Petros, Potard, Blaise, and Schoentgen, Jean
- Abstract
Deliverable D1, promoteur: Y.Laprie, LORIA, Nancy, France, info:eu-repo/semantics/published
- Published
- 2007
49. Initial Report on Speech Inversion Methods, ASPI, FET
- Author
-
Maragos, Petros, Engwall, Olov, Laprie, Yves, Maeda, Shinji, Potard, Blaise, Schoentgen, Jean, Maragos, Petros, Engwall, Olov, Laprie, Yves, Maeda, Shinji, Potard, Blaise, and Schoentgen, Jean
- Abstract
D2.1 Report, promoteur: Y. Laprie, LORIA,Nancy, France, info:eu-repo/semantics/published
- Published
- 2007
50. Initial Report on Speech Inversion Methods, ASPI, FET
- Author
-
Maragos, Petros, Engwall, Olov, Laprie, Yves, Maeda, Shinji, Potard, Blaise, Schoentgen, Jean, Maragos, Petros, Engwall, Olov, Laprie, Yves, Maeda, Shinji, Potard, Blaise, and Schoentgen, Jean
- Abstract
D2.1 Report, promoteur: Y. Laprie, LORIA,Nancy, France, info:eu-repo/semantics/published
- Published
- 2007
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