Search

Your search keyword '"Kupčinskas, L"' showing total 2 results
Start Over Author "Kupčinskas, L" Database OAIster
2 results on '"Kupčinskas, L"'

1. Etiology and Outcome of Adult and Pediatric Acute Liver Failure in Europe.

Author

Lenz, D., Hørby Jørgensen, M., Kelly, D., Cardinale, V., Geerts, A., Gonçalves Costa, I., Fichtner, A., Garbade, S.F., Hegen, B., Hilberath, J., Kleine, R. de, Kupčinskas, L., McLin, V., Niesert, M., Prado Gonzalez, V., Sturm, E., Staufner, C., Tjwa, E.T., Willemse, J., Zecher, B.F., Larsen, F.S., Sebode, M., Ytting, H., Lenz, D., Hørby Jørgensen, M., Kelly, D., Cardinale, V., Geerts, A., Gonçalves Costa, I., Fichtner, A., Garbade, S.F., Hegen, B., Hilberath, J., Kleine, R. de, Kupčinskas, L., McLin, V., Niesert, M., Prado Gonzalez, V., Sturm, E., Staufner, C., Tjwa, E.T., Willemse, J., Zecher, B.F., Larsen, F.S., Sebode, M., and Ytting, H.

Abstract

Item does not contain fulltext, Acute liver failure (ALF) is rare but life-threatening. Common causes include intoxications, infections, and metabolic disorders. Indeterminate etiology is still frequent. No systematic data on incidence, causes, and outcome of ALF across Europe are available. Via an online survey we reached out to European Reference Network Centers on rare liver diseases. Numbers and etiology of ALF cases during 2020 were retrieved and diagnostic and treatment availabilities assessed. In total, 455 cases (306 adult, 149 pediatric) were reported from 36 centers from 20 countries. Intoxication was the most common cause in adult and pediatric care. The number of cases with indeterminate etiology is low. Diagnostic tools and specific treatment options are broadly available within this network. This is the first approach to report on etiology and outcome of ALF in the pediatric and adult population in Europe. High diagnostic yield and standard of care reflects the expert status of involved centers.

Published
2023

2. Association of adverse perinatal outcomes of intrahepatic cholestasis of pregnancy with biochemical markers: results of aggregate and individual patient data meta-analyses

Author

Ovadia, C, Seed, P, Sklavounos, A, Geenes, V, Di Illio, C, Chambers, J, Kohari, K, Bacq, Y, Bozkurt, N, Brun-Furrer, R, Bull, L, Estiú, M, Grymowicz, M, Gunaydin, B, Hague, W, Haslinger, C, Hu, Y, Kawakita, T, Kebapcilar, A, Kebapcilar, L, Kondrackienė, J, Koster, M, Kowalska-Kańka, A, Kupčinskas, L, Lee, R, Locatelli, A, Macias, R, Marschall, H, Oudijk, M, Raz, Y, Rimon, E, Shan, D, Shao, Y, Tribe, R, Tripodi, V, Yayla Abide, C, Yenidede, I, Thornton, J, Chappell, L, Williamson, C, Seed, PT, Estiú, MC, Hague, WM, Kebapcilar, AG, Kondrackienė, Jūratė, Koster, Maria P H, Kowalska-Kańka, Aneta, Kupčinskas, Limas, Lee, Richard H, Macias, RIR, Marschall, HU, Oudijk, MA, Thornton, JG, Chappell, LC, Ovadia, C, Seed, P, Sklavounos, A, Geenes, V, Di Illio, C, Chambers, J, Kohari, K, Bacq, Y, Bozkurt, N, Brun-Furrer, R, Bull, L, Estiú, M, Grymowicz, M, Gunaydin, B, Hague, W, Haslinger, C, Hu, Y, Kawakita, T, Kebapcilar, A, Kebapcilar, L, Kondrackienė, J, Koster, M, Kowalska-Kańka, A, Kupčinskas, L, Lee, R, Locatelli, A, Macias, R, Marschall, H, Oudijk, M, Raz, Y, Rimon, E, Shan, D, Shao, Y, Tribe, R, Tripodi, V, Yayla Abide, C, Yenidede, I, Thornton, J, Chappell, L, Williamson, C, Seed, PT, Estiú, MC, Hague, WM, Kebapcilar, AG, Kondrackienė, Jūratė, Koster, Maria P H, Kowalska-Kańka, Aneta, Kupčinskas, Limas, Lee, Richard H, Macias, RIR, Marschall, HU, Oudijk, MA, Thornton, JG, and Chappell, LC

Abstract

Background: Intrahepatic cholestasis of pregnancy is associated with adverse perinatal outcomes, but the association with the concentration of specific biochemical markers is unclear. We aimed to quantify the adverse perinatal effects of intrahepatic cholestasis of pregnancy in women with increased serum bile acid concentrations and determine whether elevated bile acid concentrations were associated with the risk of stillbirth and preterm birth. Methods: We did a systematic review by searching PubMed, Web of Science, and Embase databases for studies published from database inception to June 1, 2018, reporting perinatal outcomes for women with intrahepatic cholestasis of pregnancy when serum bile acid concentrations were available. Inclusion criteria were studies defining intrahepatic cholestasis of pregnancy based upon pruritus and elevated serum bile acid concentrations, with or without raised liver aminotransferase concentrations. Eligible studies were case-control, cohort, and population-based studies, and randomised controlled trials, with at least 30 participants, and that reported bile acid concentrations and perinatal outcomes. Studies at potential higher risk of reporter bias were excluded, including case reports, studies not comprising cohorts, or successive cases seen in a unit; we also excluded studies with high risk of bias from groups selected (eg, a subgroup of babies with poor outcomes were explicitly excluded), conference abstracts, and Letters to the Editor without clear peer review. We also included unpublished data from two UK hospitals. We did a random effects meta-analysis to determine risk of adverse perinatal outcomes. Aggregate data for maternal and perinatal outcomes were extracted from case-control studies, and individual patient data (IPD) were requested from study authors for all types of study (as no control group was required for the IPD analysis) to assess associations between biochemical markers and adverse outcomes using logistic and

Published
2019

Catalog

Books, media, physical & digital resources
See catalog results