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The effectiveness of air bubble-mineral interaction is affected by the hydrodynamic conditions, which were investigated in a pulsating medium in which the bubble floats with a variable speed depending on the vibration frequency and amplitude. It was found that as the speed of collision between a particle and a bubble increases, the period of formation of a flotation aggregate is shortened, and the aggregate strength increases. During pulsation, the average bubble speed increases and the period of bubble rise is shortened. Pneumatic pulsating flotation machines with an active chamber volume of 0.125 to 21 m3 were full-scale tested for the flotation of potassium salts, copper-nickel and polymetallic ores, and black coal. Results showed that the machines permit fine air dispersion, high aeration rates, high flotation rates, high separation selectivity and low power consumption. The number of recleaner operations can also be reduced., The effectiveness of air bubble-mineral interaction is affected by the hydrodynamic conditions, which were investigated in a pulsating medium in which the bubble floats with a variable speed depending on the vibration frequency and amplitude. It was found that as the speed of collision between a particle and a bubble increases, the period of formation of a flotation aggregate is shortened, and the aggregate strength increases. During pulsation, the average bubble speed increases and the period of bubble rise is shortened. Pneumatic pulsating flotation machines with an active chamber volume of 0.125 to 21 m3 were full-scale tested for the flotation of potassium salts, copper-nickel and polymetallic ores, and black coal. Results showed that the machines permit fine air dispersion, high aeration rates, high flotation rates, high separation selectivity and low power consumption. The number of recleaner operations can also be reduced.