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Patients with glioblastoma die from local relapse despite surgery and high-dose radiotherapy. Resistance to radiotherapy is thought to be due to efficient DNA double-strand break (DSB) repair in stem-like cells able to survive DNA damage and repopulate the tumor. We used clinical samples and patient-derived glioblastoma stem cells (GSCs) to confirm that the DSB repair protein RAD51 is highly expressed in GSCs, which are reliant on RAD51-dependent DSB repair after radiation. RAD51 expression and RAD51 foci numbers fall when these cells move toward astrocytic differentiation. In GSCs, the small-molecule RAD51 inhibitors RI-1 and B02 prevent RAD51 focus formation, reduce DNA DSB repair, and cause significant radiosensitization. We further demonstrate that treatment with these agents combined with radiation promotes loss of stem cells defined by SOX2 expression. This indicates that RAD51-dependent repair represents an effective and specific target in GSCs.

A new type of composite, which consists of a reinforcement phase plus a matrix composed of many alternate thin layers of two different materials, has been prepared. CVI appears to be an appropriate process for the fabrication of this class of materials. We have successfully fabricated such a composite using the forced flow-thermal gradient CVI process. A carbon 2-D cloth preform was infiltrated with alternate layers of C and SiC having thicknesses of 0.01 to 0.5 micrometers Composites containing inexpensive SiC particles or platelets rather than fibrous reinforcement were also prepared. For a fixed cycle time, layer thicknesses increased with distance from the fiber surface. Crack deflection patterns indicate that the laminated matrix may contribute to mechanical toughness. The latter half of the project emphasized the CVD of Ti3SiC2 which may be a useful fiber matrix interface coating and/or matrix material. Ti3SiC2 was successfully deposited onto graphite substrates, and more recently on C and SiC cloth substrates. The reagent system TiCl4-SiCl4-CCl4-H2 was used.

Shading indicates age of rock.; "Fifth annual report plate II", 1 map 53 x 81 cm, a 1550000 W1251900 W0665600 N0494700 N0244200, Scale [ca. 1:1,550,000] (W 125°19'00"-- W 66°56'00"/N 49°47'00"-- N 24°42'00")., http://name.umdl.umich.edu/IC-CLARK1IC-X-013669886%5D39015091195233, https://quod.lib.umich.edu/cgi/i/image/api/thumb/clark1ic/013669886/39015091195233/!250,250, This map is in the public domain. Please attribute access and use of this digitized map to the Stephen S. Clark Library, University of Michigan Library., https://www.lib.umich.edu/about-us/policies/copyright-policy

Shows rail roads completed, rail roads proposed, life saving stations, county seats, light houses, military roads and trails and roads.; Relief shown by shading and spot heights.; Also available via the Internet., 1 map : col. 70 x 89 cm., a 760320 W1250000 W1160000 N0463000 N0420000, Scale [1:760,320]. 1 in. = 12 miles (W 125°00'--W 116°00'/N 46°30'--N 42°00')., http://name.umdl.umich.edu/IC-CLARK1IC-X-009674503%5D39015095421932, https://quod.lib.umich.edu/cgi/i/image/api/thumb/clark1ic/009674503/39015095421932/!250,250, This map is in the public domain. Please attribute access and use of this digitized map to the Stephen S. Clark Library, University of Michigan Library., https://www.lib.umich.edu/about-us/policies/copyright-policy

Shading indicates age of rock.; "Fifth annual report plate II", 1 map 53 x 81 cm, a 1550000 W1251900 W0665600 N0494700 N0244200, Scale [ca. 1:1,550,000] (W 125°19'00"-- W 66°56'00"/N 49°47'00"-- N 24°42'00")., http://name.umdl.umich.edu/IC-CLARK1IC-X-013669886%5D39015091195233, https://quod.lib.umich.edu/cgi/i/image/api/thumb/clark1ic/013669886/39015091195233/!250,250, This map is in the public domain. Please attribute access and use of this digitized map to the Stephen S. Clark Library, University of Michigan Library., https://www.lib.umich.edu/about-us/policies/copyright-policy

Shows rail roads completed, rail roads proposed, life saving stations, county seats, light houses, military roads and trails and roads.; Relief shown by shading and spot heights.; Also available via the Internet., 1 map : col. 70 x 89 cm., a 760320 W1250000 W1160000 N0463000 N0420000, Scale [1:760,320]. 1 in. = 12 miles (W 125°00'--W 116°00'/N 46°30'--N 42°00')., http://name.umdl.umich.edu/IC-CLARK1IC-X-009674503%5D39015095421932, https://quod.lib.umich.edu/cgi/i/image/api/thumb/clark1ic/009674503/39015095421932/!250,250, This map is in the public domain. Please attribute access and use of this digitized map to the Stephen S. Clark Library, University of Michigan Library., https://www.lib.umich.edu/about-us/policies/copyright-policy

Shading indicates age of rock.; "Fifth annual report plate II", 1 map 53 x 81 cm, a 1550000 W1251900 W0665600 N0494700 N0244200, Scale [ca. 1:1,550,000] (W 125°19'00"-- W 66°56'00"/N 49°47'00"-- N 24°42'00")., http://name.umdl.umich.edu/IC-CLARK1IC-X-013669886%5D39015091195233, https://quod.lib.umich.edu/cgi/i/image/api/thumb/clark1ic/013669886/39015091195233/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. These materials are believed to be in the public domain in the United States; however, if you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact Clark Library for Maps Digital Collections Help: clark1ic-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: LibraryIT-info@umich.edu. DPLA No Copyright - United States, https://www.lib.umich.edu/about-us/policies/copyright-policy

Shows rail roads completed, rail roads proposed, life saving stations, county seats, light houses, military roads and trails and roads.; Relief shown by shading and spot heights.; Also available via the Internet., 1 map : col. 70 x 89 cm., a 760320 W1250000 W1160000 N0463000 N0420000, Scale [1:760,320]. 1 in. = 12 miles (W 125°00'--W 116°00'/N 46°30'--N 42°00')., http://name.umdl.umich.edu/IC-CLARK1IC-X-009674503%5D39015095421932, https://quod.lib.umich.edu/cgi/i/image/api/thumb/clark1ic/009674503/39015095421932/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. These materials are believed to be in the public domain in the United States; however, if you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact Clark Library for Maps Digital Collections Help: clark1ic-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: LibraryIT-info@umich.edu. DPLA No Copyright - United States, https://www.lib.umich.edu/about-us/policies/copyright-policy

The report describes optical design and brightness measurements of Cs(+) and I(-) ion sources. Design and operation are also discussed., See also AD772833.

The analytic and experimental studies conducted during Phase 1 of the program indicate that it is possible to design both cesium and iodine sources to meet the specified brightness requirements of 200 and 100 A/cm squared sr respectively. No reasons were uncovered as to why these two types of sources cannot operate in the same vacuum environment in such a manner that the ion species available to the AMS can be rapidly changed. Prototype hardware will be developed in Phase 2 to demonstrate this ability.

Debajo del título y mención de responsabilidad, nota explicativa sobre los organismos que participaron en el levantamiento del mapa, En el ángulo inferior izquierdo inserta: 1. Alaska. - Escala [ca. 1:8.950.000]. 250 Stat. Miles [= 4,5 cm]. - Márgenes graduados. - Indica las fronteras con líneas de color. - 20 x 34,5 cm, Escala también expresada en 100 millas [= 8 cm], Márgenes graduados. - Relieve por curvas de nivel . - Hidrografía. - Red del ferrocarril. - Divisiones administrativas diferenciadas por líneas de color. - Ciudades representadas por planos. - Abundante toponimia, "First published in 1890"