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1. Genome-wide Association Study of Bladder Cancer Reveals New Biological and Translational Insights

Author

Koutros, S, Kiemeney, LA, Choudhury, PP, Milne, RL, de Maturana, EL, Ye, Y, Joseph, V, Florez-Vargas, O, Dyrskjot, L, Figueroa, J, Dutta, D, Giles, GG, Hildebrandt, MAT, Offit, K, Kogevinas, M, Weiderpass, E, McCullough, ML, Freedman, ND, Albanes, D, Kooperberg, C, Cortessis, VK, Karagas, MR, Johnson, A, Schwenn, MR, Baris, D, Furberg, H, Bajorin, DF, Cussenot, O, Cancel-Tassin, G, Benhamou, S, Kraft, P, Porru, S, Carta, A, Bishop, T, Southey, MC, Matullo, G, Fletcher, T, Kumar, R, Taylor, JA, Lamy, P, Prip, F, Kalisz, M, Weinstein, SJ, Hengstler, JG, Selinski, S, Harland, M, Teo, M, Kiltie, AE, Tardon, A, Serra, C, Carrato, A, Garcia-Closas, R, Lloreta, J, Schned, A, Lenz, P, Riboli, E, Brennan, P, Tjonneland, A, Otto, T, Ovsiannikov, D, Volkert, F, Vermeulen, SH, Aben, KK, Galesloot, TE, Turman, C, De Vivo, I, Giovannucci, E, Hunter, DJ, Hohensee, C, Hunt, R, V. Patel, A, Huang, W-Y, Thorleifsson, G, Gago-Dominguez, M, Amiano, P, Golka, K, Stern, MC, Yan, W, Liu, J, Alfred, S, Katta, S, Hutchinson, A, Hicks, B, Wheeler, WA, Purdue, MP, McGlynn, KA, Kitahara, CM, Haiman, CA, Greene, MH, Rafnar, T, Chatterjee, N, Chanock, SJ, Wu, X, Real, FX, Silverman, DT, Garcia-Closas, M, Stefansson, K, Prokunina-Olsson, L, Malats, N, Rothman, N, Koutros, S, Kiemeney, LA, Choudhury, PP, Milne, RL, de Maturana, EL, Ye, Y, Joseph, V, Florez-Vargas, O, Dyrskjot, L, Figueroa, J, Dutta, D, Giles, GG, Hildebrandt, MAT, Offit, K, Kogevinas, M, Weiderpass, E, McCullough, ML, Freedman, ND, Albanes, D, Kooperberg, C, Cortessis, VK, Karagas, MR, Johnson, A, Schwenn, MR, Baris, D, Furberg, H, Bajorin, DF, Cussenot, O, Cancel-Tassin, G, Benhamou, S, Kraft, P, Porru, S, Carta, A, Bishop, T, Southey, MC, Matullo, G, Fletcher, T, Kumar, R, Taylor, JA, Lamy, P, Prip, F, Kalisz, M, Weinstein, SJ, Hengstler, JG, Selinski, S, Harland, M, Teo, M, Kiltie, AE, Tardon, A, Serra, C, Carrato, A, Garcia-Closas, R, Lloreta, J, Schned, A, Lenz, P, Riboli, E, Brennan, P, Tjonneland, A, Otto, T, Ovsiannikov, D, Volkert, F, Vermeulen, SH, Aben, KK, Galesloot, TE, Turman, C, De Vivo, I, Giovannucci, E, Hunter, DJ, Hohensee, C, Hunt, R, V. Patel, A, Huang, W-Y, Thorleifsson, G, Gago-Dominguez, M, Amiano, P, Golka, K, Stern, MC, Yan, W, Liu, J, Alfred, S, Katta, S, Hutchinson, A, Hicks, B, Wheeler, WA, Purdue, MP, McGlynn, KA, Kitahara, CM, Haiman, CA, Greene, MH, Rafnar, T, Chatterjee, N, Chanock, SJ, Wu, X, Real, FX, Silverman, DT, Garcia-Closas, M, Stefansson, K, Prokunina-Olsson, L, Malats, N, and Rothman, N

Abstract

BACKGROUND: Genomic regions identified by genome-wide association studies (GWAS) for bladder cancer risk provide new insights into etiology. OBJECTIVE: To identify new susceptibility variants for bladder cancer in a meta-analysis of new and existing genome-wide genotype data. DESIGN, SETTING, AND PARTICIPANTS: Data from 32 studies that includes 13,790 bladder cancer cases and 343,502 controls of European ancestry were used for meta-analysis. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSES: Log-additive associations of genetic variants were assessed using logistic regression models. A fixed-effects model was used for meta-analysis of the results. Stratified analyses were conducted to evaluate effect modification by sex and smoking status. A polygenic risk score (PRS) was generated on the basis of known and novel susceptibility variants and tested for interaction with smoking. RESULTS AND LIMITATIONS: Multiple novel bladder cancer susceptibility loci (6p.22.3, 7q36.3, 8q21.13, 9p21.3, 10q22.1, 19q13.33) as well as improved signals in three known regions (4p16.3, 5p15.33, 11p15.5) were identified, bringing the number of independent markers at genome-wide significance (p < 5 × 10-8) to 24. The 4p16.3 (FGFR3/TACC3) locus was associated with a stronger risk for women than for men (p-interaction = 0.002). Bladder cancer risk was increased by interactions between smoking status and genetic variants at 8p22 (NAT2; multiplicative p value for interaction [pM-I] = 0.004), 8q21.13 (PAG1; pM-I = 0.01), and 9p21.3 (LOC107987026/MTAP/CDKN2A; pM-I = 0.02). The PRS based on the 24 independent GWAS markers (odds ratio per standard deviation increase 1.49, 95% confidence interval 1.44-1.53), which also showed comparable results in two prospective cohorts (UK Biobank, PLCO trial), revealed an approximately fourfold difference in the lifetime risk of bladder cancer according to the PRS (e.g., 1st vs 10th decile) for both smokers and nonsmokers. CONCLUSIONS: We report novel loci associated

Published
2023

2. A meta-analysis of pre-pregnancy maternal body mass index and placental DNA methylation identifies 27 CpG sites with implications for mother-child health

Author

Fernandez-Jimenez, N, Fore, R, Cilleros-Portet, A, Lepeule, J, Perron, P, Kvist, T, Tian, F-Y, Lesseur, C, Binder, AM, Lozano, M, Martorell-Marugan, J, Loke, YJ, Bakulski, KM, Zhu, Y, Forhan, A, Sammallahti, S, Everson, TM, Chen, J, Michels, KB, Belmonte, T, Carmona-Saez, P, Halliday, J, Fallin, MD, LaSalle, JM, Tost, J, Czamara, D, Fernandez, MF, Gomez-Martin, A, Craig, JM, Gonzalez-Alzaga, B, Schmidt, RJ, Dou, JF, Muggli, E, Lacasana, M, Vrijheid, M, Marsit, CJ, Karagas, MR, Raikkonen, K, Bouchard, L, Heude, B, Santa-Marina, L, Bustamante, M, Hivert, M-F, Bilbao, JR, Fernandez-Jimenez, N, Fore, R, Cilleros-Portet, A, Lepeule, J, Perron, P, Kvist, T, Tian, F-Y, Lesseur, C, Binder, AM, Lozano, M, Martorell-Marugan, J, Loke, YJ, Bakulski, KM, Zhu, Y, Forhan, A, Sammallahti, S, Everson, TM, Chen, J, Michels, KB, Belmonte, T, Carmona-Saez, P, Halliday, J, Fallin, MD, LaSalle, JM, Tost, J, Czamara, D, Fernandez, MF, Gomez-Martin, A, Craig, JM, Gonzalez-Alzaga, B, Schmidt, RJ, Dou, JF, Muggli, E, Lacasana, M, Vrijheid, M, Marsit, CJ, Karagas, MR, Raikkonen, K, Bouchard, L, Heude, B, Santa-Marina, L, Bustamante, M, Hivert, M-F, and Bilbao, JR

Abstract

Higher maternal pre-pregnancy body mass index (ppBMI) is associated with increased neonatal morbidity, as well as with pregnancy complications and metabolic outcomes in offspring later in life. The placenta is a key organ in fetal development and has been proposed to act as a mediator between the mother and different health outcomes in children. The overall aim of the present work is to investigate the association of ppBMI with epigenome-wide placental DNA methylation (DNAm) in 10 studies from the PACE consortium, amounting to 2631 mother-child pairs. We identify 27 CpG sites at which we observe placental DNAm variations of up to 2.0% per 10 ppBMI-unit. The CpGs that are differentially methylated in placenta do not overlap with CpGs identified in previous studies in cord blood DNAm related to ppBMI. Many of the identified CpGs are located in open sea regions, are often close to obesity-related genes such as GPX1 and LGR4 and altogether, are enriched in cancer and oxidative stress pathways. Our findings suggest that placental DNAm could be one of the mechanisms by which maternal obesity is associated with metabolic health outcomes in newborns and children, although further studies will be needed in order to corroborate these findings.

Published
2022

3. Placental DNA methylation signatures of maternal smoking during pregnancy and potential impacts on fetal growth

Author

Everson, TM, Vives-Usano, M, Seyve, E, Cardenas, A, Lacasaña, M, Craig, Jeffrey, Lesseur, C, Baker, ER, Fernandez-Jimenez, N, Heude, B, Perron, P, Gónzalez-Alzaga, B, Halliday, J, Deyssenroth, MA, Karagas, MR, Íñiguez, C, Bouchard, L, Carmona-Sáez, P, Loke, YJ, Hao, K, Belmonte, T, Charles, MA, Martorell-Marugán, J, Muggli, E, Chen, J, Fernández, MF, Tost, J, Gómez-Martín, A, London, SJ, Sunyer, J, Marsit, CJ, Lepeule, J, Hivert, MF, Bustamante, M, Everson, TM, Vives-Usano, M, Seyve, E, Cardenas, A, Lacasaña, M, Craig, Jeffrey, Lesseur, C, Baker, ER, Fernandez-Jimenez, N, Heude, B, Perron, P, Gónzalez-Alzaga, B, Halliday, J, Deyssenroth, MA, Karagas, MR, Íñiguez, C, Bouchard, L, Carmona-Sáez, P, Loke, YJ, Hao, K, Belmonte, T, Charles, MA, Martorell-Marugán, J, Muggli, E, Chen, J, Fernández, MF, Tost, J, Gómez-Martín, A, London, SJ, Sunyer, J, Marsit, CJ, Lepeule, J, Hivert, MF, and Bustamante, M

Abstract

AbstractMaternal smoking during pregnancy (MSDP) contributes to poor birth outcomes, in part through disrupted placental functions, which may be reflected in the placental epigenome. Here we present a meta-analysis of the associations between MSDP and placental DNA methylation (DNAm) and between DNAm and birth outcomes within the Pregnancy And Childhood Epigenetics (PACE) consortium (N = 1700, 344 with MSDP). We identify 443 CpGs that are associated with MSDP, of which 142 associated with birth outcomes, 40 associated with gene expression, and 13 CpGs are associated with all three. Only two CpGs have consistent associations from a prior meta-analysis of cord blood DNAm, demonstrating substantial tissue-specific responses to MSDP. The placental MSDP-associated CpGs are enriched for environmental response genes, growth-factor signaling, and inflammation, which play important roles in placental function. We demonstrate links between placental DNAm, MSDP and poor birth outcomes, which may better inform the mechanisms through which MSDP impacts placental function and fetal growth.

Published
2021

4. Placental DNA methylation signatures of maternal smoking during pregnancy and potential impacts on fetal growth

Author

Everson, TM, Vives-Usano, M, Seyve, E, Cardenas, A, Lacasana, M, Craig, JM, Lesseur, C, Baker, ER, Fernandez-Jimenez, N, Heude, B, Perron, P, Gonzalez-Alzaga, B, Halliday, J, Deyssenroth, MA, Karagas, MR, Iniguez, C, Bouchard, L, Carmona-Saez, P, Loke, YJ, Hao, K, Belmonte, T, Charles, MA, Martorell-Marugan, J, Muggli, E, Chen, J, Fernandez, MF, Tost, J, Gomez-Martin, A, London, SJ, Sunyer, J, Marsit, CJ, Lepeule, J, Hivert, M-F, Bustamante, M, Everson, TM, Vives-Usano, M, Seyve, E, Cardenas, A, Lacasana, M, Craig, JM, Lesseur, C, Baker, ER, Fernandez-Jimenez, N, Heude, B, Perron, P, Gonzalez-Alzaga, B, Halliday, J, Deyssenroth, MA, Karagas, MR, Iniguez, C, Bouchard, L, Carmona-Saez, P, Loke, YJ, Hao, K, Belmonte, T, Charles, MA, Martorell-Marugan, J, Muggli, E, Chen, J, Fernandez, MF, Tost, J, Gomez-Martin, A, London, SJ, Sunyer, J, Marsit, CJ, Lepeule, J, Hivert, M-F, and Bustamante, M

Abstract

Maternal smoking during pregnancy (MSDP) contributes to poor birth outcomes, in part through disrupted placental functions, which may be reflected in the placental epigenome. Here we present a meta-analysis of the associations between MSDP and placental DNA methylation (DNAm) and between DNAm and birth outcomes within the Pregnancy And Childhood Epigenetics (PACE) consortium (N = 1700, 344 with MSDP). We identify 443 CpGs that are associated with MSDP, of which 142 associated with birth outcomes, 40 associated with gene expression, and 13 CpGs are associated with all three. Only two CpGs have consistent associations from a prior meta-analysis of cord blood DNAm, demonstrating substantial tissue-specific responses to MSDP. The placental MSDP-associated CpGs are enriched for environmental response genes, growth-factor signaling, and inflammation, which play important roles in placental function. We demonstrate links between placental DNAm, MSDP and poor birth outcomes, which may better inform the mechanisms through which MSDP impacts placental function and fetal growth.

Published
2021

5. Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight.

Author

Küpers, LK, Monnereau, C, Sharp, GC, Yousefi, P, Salas, LA, Ghantous, A, Page, CM, Reese, SE, Wilcox, AJ, Czamara, D, Starling, AP, Novoloaca, A, Lent, S, Roy, R, Hoyo, C, Breton, CV, Allard, C, Just, AC, Bakulski, KM, Holloway, JW, Everson, TM, Xu, C-J, Huang, R-C, van der Plaat, DA, Wielscher, M, Merid, SK, Ullemar, V, Rezwan, FI, Lahti, J, van Dongen, J, Langie, SAS, Richardson, TG, Magnus, MC, Nohr, EA, Xu, Z, Duijts, L, Zhao, S, Zhang, W, Plusquin, M, DeMeo, DL, Solomon, O, Heimovaara, JH, Jima, DD, Gao, L, Bustamante, M, Perron, P, Wright, RO, Hertz-Picciotto, I, Zhang, H, Karagas, MR, Gehring, U, Marsit, CJ, Beilin, LJ, Vonk, JM, Jarvelin, M-R, Bergström, A, Örtqvist, AK, Ewart, S, Villa, PM, Moore, SE, Willemsen, G, Standaert, ARL, Håberg, SE, Sørensen, TIA, Taylor, JA, Räikkönen, K, Yang, IV, Kechris, K, Nawrot, TS, Silver, MJ, Gong, YY, Richiardi, L, Kogevinas, M, Litonjua, AA, Eskenazi, B, Huen, K, Mbarek, H, Maguire, RL, Dwyer, T, Vrijheid, M, Bouchard, L, Baccarelli, AA, Croen, LA, Karmaus, W, Anderson, D, de Vries, M, Sebert, S, Kere, J, Karlsson, R, Arshad, SH, Hämäläinen, E, Routledge, MN, Boomsma, DI, Feinberg, AP, Newschaffer, CJ, Govarts, E, Moisse, M, Fallin, MD, Melén, E, Prentice, AM, Kajantie, E, Almqvist, C, Oken, E, Dabelea, D, Boezen, HM, Melton, PE, Wright, RJ, Koppelman, GH, Trevisi, L, Hivert, M-F, Sunyer, J, Munthe-Kaas, MC, Murphy, SK, Corpeleijn, E, Wiemels, J, Holland, N, Herceg, Z, Binder, EB, Davey Smith, G, Jaddoe, VWV, Lie, RT, Nystad, W, London, SJ, Lawlor, DA, Relton, CL, Snieder, H, Felix, JF, Küpers, LK, Monnereau, C, Sharp, GC, Yousefi, P, Salas, LA, Ghantous, A, Page, CM, Reese, SE, Wilcox, AJ, Czamara, D, Starling, AP, Novoloaca, A, Lent, S, Roy, R, Hoyo, C, Breton, CV, Allard, C, Just, AC, Bakulski, KM, Holloway, JW, Everson, TM, Xu, C-J, Huang, R-C, van der Plaat, DA, Wielscher, M, Merid, SK, Ullemar, V, Rezwan, FI, Lahti, J, van Dongen, J, Langie, SAS, Richardson, TG, Magnus, MC, Nohr, EA, Xu, Z, Duijts, L, Zhao, S, Zhang, W, Plusquin, M, DeMeo, DL, Solomon, O, Heimovaara, JH, Jima, DD, Gao, L, Bustamante, M, Perron, P, Wright, RO, Hertz-Picciotto, I, Zhang, H, Karagas, MR, Gehring, U, Marsit, CJ, Beilin, LJ, Vonk, JM, Jarvelin, M-R, Bergström, A, Örtqvist, AK, Ewart, S, Villa, PM, Moore, SE, Willemsen, G, Standaert, ARL, Håberg, SE, Sørensen, TIA, Taylor, JA, Räikkönen, K, Yang, IV, Kechris, K, Nawrot, TS, Silver, MJ, Gong, YY, Richiardi, L, Kogevinas, M, Litonjua, AA, Eskenazi, B, Huen, K, Mbarek, H, Maguire, RL, Dwyer, T, Vrijheid, M, Bouchard, L, Baccarelli, AA, Croen, LA, Karmaus, W, Anderson, D, de Vries, M, Sebert, S, Kere, J, Karlsson, R, Arshad, SH, Hämäläinen, E, Routledge, MN, Boomsma, DI, Feinberg, AP, Newschaffer, CJ, Govarts, E, Moisse, M, Fallin, MD, Melén, E, Prentice, AM, Kajantie, E, Almqvist, C, Oken, E, Dabelea, D, Boezen, HM, Melton, PE, Wright, RJ, Koppelman, GH, Trevisi, L, Hivert, M-F, Sunyer, J, Munthe-Kaas, MC, Murphy, SK, Corpeleijn, E, Wiemels, J, Holland, N, Herceg, Z, Binder, EB, Davey Smith, G, Jaddoe, VWV, Lie, RT, Nystad, W, London, SJ, Lawlor, DA, Relton, CL, Snieder, H, and Felix, JF

Abstract

Birthweight is associated with health outcomes across the life course, DNA methylation may be an underlying mechanism. In this meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birth cohorts in the Pregnancy And Childhood Epigenetics Consortium, we find that DNA methylation in neonatal blood is associated with birthweight at 914 sites, with a difference in birthweight ranging from -183 to 178 grams per 10% increase in methylation (PBonferroni < 1.06 x 10-7). In additional analyses in 7,278 participants, <1.3% of birthweight-associated differential methylation is also observed in childhood and adolescence, but not adulthood. Birthweight-related CpGs overlap with some Bonferroni-significant CpGs that were previously reported to be related to maternal smoking (55/914, p = 6.12 x 10-74) and BMI in pregnancy (3/914, p = 1.13x10-3), but not with those related to folate levels in pregnancy. Whether the associations that we observe are causal or explained by confounding or fetal growth influencing DNA methylation (i.e. reverse causality) requires further research.

Published
2019

6. Interaktion von vier genetischen Risikovarianten für das Harnblasenkarzinom

Author

Selinski, S, Blaszkewicz, M, Ickstadt, K, Gerullis, H, Otto, T, Roth, E, Volkert, F, Ovsiannikov, D, Moormann, O, Banfi, G, Nyirady, P, Vermeulen, SH, Garcia-Closas, M, Figueroa, JD, Johnson, A, Karagas, MR, Kogevinas, M, Malats, N, Schwenn, M, Silverman, DT, Koutros, S, Rothman, N, Kiemeney, LA, Hengstler, JG, Golka, K, Selinski, S, Blaszkewicz, M, Ickstadt, K, Gerullis, H, Otto, T, Roth, E, Volkert, F, Ovsiannikov, D, Moormann, O, Banfi, G, Nyirady, P, Vermeulen, SH, Garcia-Closas, M, Figueroa, JD, Johnson, A, Karagas, MR, Kogevinas, M, Malats, N, Schwenn, M, Silverman, DT, Koutros, S, Rothman, N, Kiemeney, LA, Hengstler, JG, and Golka, K

Published
2018

7. Cohort Profile: Pregnancy And Childhood Epigenetics (PACE) Consortium.

Author

Felix, JF, Joubert, BR, Baccarelli, AA, Sharp, GC, Almqvist, C, Annesi-Maesano, I, Arshad, H, Baïz, N, Bakermans-Kranenburg, MJ, Bakulski, KM, Binder, EB, Bouchard, L, Breton, CV, Brunekreef, B, Brunst, KJ, Burchard, EG, Bustamante, M, Chatzi, L, Cheng Munthe-Kaas, M, Corpeleijn, E, Czamara, D, Dabelea, D, Davey Smith, G, De Boever, P, Duijts, L, Dwyer, T, Eng, C, Eskenazi, B, Everson, TM, Falahi, F, Fallin, MD, Farchi, S, Fernandez, MF, Gao, L, Gaunt, TR, Ghantous, A, Gillman, MW, Gonseth, S, Grote, V, Gruzieva, O, Håberg, SE, Herceg, Z, Hivert, M-F, Holland, N, Holloway, JW, Hoyo, C, Hu, D, Huang, R-C, Huen, K, Järvelin, M-R, Jima, DD, Just, AC, Karagas, MR, Karlsson, R, Karmaus, W, Kechris, KJ, Kere, J, Kogevinas, M, Koletzko, B, Koppelman, GH, Küpers, LK, Ladd-Acosta, C, Lahti, J, Lambrechts, N, Langie, SAS, Lie, RT, Liu, AH, Magnus, MC, Magnus, P, Maguire, RL, Marsit, CJ, McArdle, W, Melén, E, Melton, P, Murphy, SK, Nawrot, TS, Nisticò, L, Nohr, EA, Nordlund, B, Nystad, W, Oh, SS, Oken, E, Page, CM, Perron, P, Pershagen, G, Pizzi, C, Plusquin, M, Raikkonen, K, Reese, SE, Reischl, E, Richiardi, L, Ring, S, Roy, RP, Rzehak, P, Schoeters, G, Schwartz, DA, Sebert, S, Snieder, H, Sørensen, TIA, Starling, AP, Sunyer, J, Taylor, JA, Tiemeier, H, Ullemar, V, Vafeiadi, M, Van Ijzendoorn, MH, Vonk, JM, Vriens, A, Vrijheid, M, Wang, P, Wiemels, JL, Wilcox, AJ, Wright, RJ, Xu, C-J, Xu, Z, Yang, IV, Yousefi, P, Zhang, H, Zhang, W, Zhao, S, Agha, G, Relton, CL, Jaddoe, VWV, London, SJ, Felix, JF, Joubert, BR, Baccarelli, AA, Sharp, GC, Almqvist, C, Annesi-Maesano, I, Arshad, H, Baïz, N, Bakermans-Kranenburg, MJ, Bakulski, KM, Binder, EB, Bouchard, L, Breton, CV, Brunekreef, B, Brunst, KJ, Burchard, EG, Bustamante, M, Chatzi, L, Cheng Munthe-Kaas, M, Corpeleijn, E, Czamara, D, Dabelea, D, Davey Smith, G, De Boever, P, Duijts, L, Dwyer, T, Eng, C, Eskenazi, B, Everson, TM, Falahi, F, Fallin, MD, Farchi, S, Fernandez, MF, Gao, L, Gaunt, TR, Ghantous, A, Gillman, MW, Gonseth, S, Grote, V, Gruzieva, O, Håberg, SE, Herceg, Z, Hivert, M-F, Holland, N, Holloway, JW, Hoyo, C, Hu, D, Huang, R-C, Huen, K, Järvelin, M-R, Jima, DD, Just, AC, Karagas, MR, Karlsson, R, Karmaus, W, Kechris, KJ, Kere, J, Kogevinas, M, Koletzko, B, Koppelman, GH, Küpers, LK, Ladd-Acosta, C, Lahti, J, Lambrechts, N, Langie, SAS, Lie, RT, Liu, AH, Magnus, MC, Magnus, P, Maguire, RL, Marsit, CJ, McArdle, W, Melén, E, Melton, P, Murphy, SK, Nawrot, TS, Nisticò, L, Nohr, EA, Nordlund, B, Nystad, W, Oh, SS, Oken, E, Page, CM, Perron, P, Pershagen, G, Pizzi, C, Plusquin, M, Raikkonen, K, Reese, SE, Reischl, E, Richiardi, L, Ring, S, Roy, RP, Rzehak, P, Schoeters, G, Schwartz, DA, Sebert, S, Snieder, H, Sørensen, TIA, Starling, AP, Sunyer, J, Taylor, JA, Tiemeier, H, Ullemar, V, Vafeiadi, M, Van Ijzendoorn, MH, Vonk, JM, Vriens, A, Vrijheid, M, Wang, P, Wiemels, JL, Wilcox, AJ, Wright, RJ, Xu, C-J, Xu, Z, Yang, IV, Yousefi, P, Zhang, H, Zhang, W, Zhao, S, Agha, G, Relton, CL, Jaddoe, VWV, and London, SJ

Published
2018

8. Interaktion von vier genetischen Risikovarianten für das Harnblasenkarzinom

Author

Selinski, S, Blaszkewicz, M, Ickstadt, K, Gerullis, H, Otto, T, Roth, E, Volkert, F, Ovsiannikov, D, Moormann, O, Banfi, G, Nyirady, P, Vermeulen, SH, Garcia-Closas, M, Figueroa, JD, Johnson, A, Karagas, MR, Kogevinas, M, Malats, N, Schwenn, M, Silverman, DT, Koutros, S, Rothman, N, Kiemeney, LA, Hengstler, JG, Golka, K, Selinski, S, Blaszkewicz, M, Ickstadt, K, Gerullis, H, Otto, T, Roth, E, Volkert, F, Ovsiannikov, D, Moormann, O, Banfi, G, Nyirady, P, Vermeulen, SH, Garcia-Closas, M, Figueroa, JD, Johnson, A, Karagas, MR, Kogevinas, M, Malats, N, Schwenn, M, Silverman, DT, Koutros, S, Rothman, N, Kiemeney, LA, Hengstler, JG, and Golka, K

Published
2018

9. Cohort Profile: Pregnancy And Childhood Epigenetics (PACE) Consortium

Author

Felix, Janine, Joubert, BR, Baccarelli, AA, Sharp, GC, Almqvist, C, Annesi-Maesano, I, Arshad, H, Baiz, N, Bakermans-Kranenburg, MJ, Bakulski, KM, Binder, EB, Bouchard, L, Breton, CV, Brunekreef, B, Brunst, KJ, Burchard, EG, Bustamante, M, Chatzi, L, Munthe-Kaas, MC, Corpeleijn, E, Czamara, D, Dabelea, D, Smith, GD, De Boever, P, Duijts, Liesbeth, Dwyer, T, Eng, C, Eskenazi, B, Everson, TM, Falahi, F, Fallin, MD, Farchi, S, Fernandez, MF, Gao, L, Gaunt, TR, Ghantous, A, Gillman, MW, Gonseth, S, Grote, V, Gruzieva, O, Haberg, SE, Herceg, Z, Hivert, MF, Holland, N, Holloway, JW, Hoyo, C, Hu, DL, Huang, RC, Huen, K, Jarvelin, MR, Jima, DD, Just, AC, Karagas, MR, Karlsson, R, Karmaus, W, Kechris, KJ, Kere, J, Kogevinas, M, Koletzko, B, Koppelman, GH, Kupers, LK, Ladd-Acosta, C, Lahti, J, Lambrechts, N, Langie, SAS, Lie, RT, Liu, AH, Magnus, MC, Magnus, P, Maguire, RL, Marsit, CJ, McArdle, W, Melen, E, Melton, P, Murphy, SK, Nawrot, TS, Nistico, L, Nohr, EA, Nordlund, B, Nystad, W, Oh, SS, Oken, E, Page, CM, Perron, P, Pershagen, G, Pizzi, C, Plusquin, M, Raikkonen, K, Reese, SE, Reischl, E, Richiardi, L, Ring, S, Roy, RP, Rzehak, P, Schoeters, G, Schwartz, DA, Sebert, S, Snieder, H, Sorensen, TIA, Starling, AP, Sunyer, J, Ataylor, J, Tiemeier, Henning, Ullemar, V, Vafeiadi, M, van IJzendoorn, Marinus, Vonk, JM, Vriens, A, Vrijheid, M, Wang, P, Wiemels, JL, Wilcox, AJ, Wright, RJ, Xu, CJ, Xu, ZL, Yang, IV, Yousefi, P, Zhang, HM, Zhang, WM, Zhao, SS, Agha, G, Relton, CL, Jaddoe, Vincent, London, SJ, Felix, Janine, Joubert, BR, Baccarelli, AA, Sharp, GC, Almqvist, C, Annesi-Maesano, I, Arshad, H, Baiz, N, Bakermans-Kranenburg, MJ, Bakulski, KM, Binder, EB, Bouchard, L, Breton, CV, Brunekreef, B, Brunst, KJ, Burchard, EG, Bustamante, M, Chatzi, L, Munthe-Kaas, MC, Corpeleijn, E, Czamara, D, Dabelea, D, Smith, GD, De Boever, P, Duijts, Liesbeth, Dwyer, T, Eng, C, Eskenazi, B, Everson, TM, Falahi, F, Fallin, MD, Farchi, S, Fernandez, MF, Gao, L, Gaunt, TR, Ghantous, A, Gillman, MW, Gonseth, S, Grote, V, Gruzieva, O, Haberg, SE, Herceg, Z, Hivert, MF, Holland, N, Holloway, JW, Hoyo, C, Hu, DL, Huang, RC, Huen, K, Jarvelin, MR, Jima, DD, Just, AC, Karagas, MR, Karlsson, R, Karmaus, W, Kechris, KJ, Kere, J, Kogevinas, M, Koletzko, B, Koppelman, GH, Kupers, LK, Ladd-Acosta, C, Lahti, J, Lambrechts, N, Langie, SAS, Lie, RT, Liu, AH, Magnus, MC, Magnus, P, Maguire, RL, Marsit, CJ, McArdle, W, Melen, E, Melton, P, Murphy, SK, Nawrot, TS, Nistico, L, Nohr, EA, Nordlund, B, Nystad, W, Oh, SS, Oken, E, Page, CM, Perron, P, Pershagen, G, Pizzi, C, Plusquin, M, Raikkonen, K, Reese, SE, Reischl, E, Richiardi, L, Ring, S, Roy, RP, Rzehak, P, Schoeters, G, Schwartz, DA, Sebert, S, Snieder, H, Sorensen, TIA, Starling, AP, Sunyer, J, Ataylor, J, Tiemeier, Henning, Ullemar, V, Vafeiadi, M, van IJzendoorn, Marinus, Vonk, JM, Vriens, A, Vrijheid, M, Wang, P, Wiemels, JL, Wilcox, AJ, Wright, RJ, Xu, CJ, Xu, ZL, Yang, IV, Yousefi, P, Zhang, HM, Zhang, WM, Zhao, SS, Agha, G, Relton, CL, Jaddoe, Vincent, and London, SJ

Published
2018

10. Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: findings from the pregnancy and childhood epigenetics (PACE) consortium

Author

Sharp, GC, Salas, LA, Monnereau, Claire, Allard, C, Yousefi, P, Everson, TM, Bohlin, J, Xu, ZL, Huang, RC, Reese, SE, Xu, CJ, Baiz, N, Hoyo, C, Agha, G, Roy, R, Holloway, JW, Ghantous, A, Merid, SK, Bakulski, KM, Kupers, LK, Zhang, HM, Richmond, Rebecca, Page, CM, Duijts, Liesbeth, Lie, RT, Melton, PE, Vonk, JM, Nohr, EA, Williams-DeVane, C, Huen, K, Rifas-Shiman, SL, Ruiz-Arenas, C, Gonseth, S, Rezwan, FI, Herceg, Z, Ekstrom, S, Croen, L, Falahi, F, Perron, P, Karagas, MR, Quraishi, BM, Suderman, M, Magnus, MC, Jaddoe, Vincent, Taylor, JA, Anderson, D, Zhao, SS, Smit, HA, Josey, MJ, Bradman, A, Baccarelli, AA, Bustamante, M, Haberg, SE, Pershagen, G, Hertz-Picciotto, I, Newschaffer, C, Corpeleijn, E, Bouchard, L, Lawlor, DA, Maguire, RL, Barcellos, LF, Smith, GD, Eskenazi, B, Karmaus, W, Marsit, CJ, Hivert, MF, Snieder, H, Fallin, MD, Melen, E, Munthe-Kaas, MC, Arshad, H, Wiemels, JL, Annesi-Maesano, I, Vrijheid, M, Oken, E, Holland, N, Murphy, SK, Sorensen, TIA, Koppelman, GH, Newnham, JP, Wilcox, AJ, Nystad, W, London, SJ, Felix, Janine, Relton, CL, Sharp, GC, Salas, LA, Monnereau, Claire, Allard, C, Yousefi, P, Everson, TM, Bohlin, J, Xu, ZL, Huang, RC, Reese, SE, Xu, CJ, Baiz, N, Hoyo, C, Agha, G, Roy, R, Holloway, JW, Ghantous, A, Merid, SK, Bakulski, KM, Kupers, LK, Zhang, HM, Richmond, Rebecca, Page, CM, Duijts, Liesbeth, Lie, RT, Melton, PE, Vonk, JM, Nohr, EA, Williams-DeVane, C, Huen, K, Rifas-Shiman, SL, Ruiz-Arenas, C, Gonseth, S, Rezwan, FI, Herceg, Z, Ekstrom, S, Croen, L, Falahi, F, Perron, P, Karagas, MR, Quraishi, BM, Suderman, M, Magnus, MC, Jaddoe, Vincent, Taylor, JA, Anderson, D, Zhao, SS, Smit, HA, Josey, MJ, Bradman, A, Baccarelli, AA, Bustamante, M, Haberg, SE, Pershagen, G, Hertz-Picciotto, I, Newschaffer, C, Corpeleijn, E, Bouchard, L, Lawlor, DA, Maguire, RL, Barcellos, LF, Smith, GD, Eskenazi, B, Karmaus, W, Marsit, CJ, Hivert, MF, Snieder, H, Fallin, MD, Melen, E, Munthe-Kaas, MC, Arshad, H, Wiemels, JL, Annesi-Maesano, I, Vrijheid, M, Oken, E, Holland, N, Murphy, SK, Sorensen, TIA, Koppelman, GH, Newnham, JP, Wilcox, AJ, Nystad, W, London, SJ, Felix, Janine, and Relton, CL

Published
2017

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