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1. Die Bedeutung nachhaltiger Ernährung für die Vermeidung von Übergewicht und Adipositas: Ergebnisse einer systematischen Übersichtsarbeit und Metaanalyse

Author: Jochem, C, Reger, C, Sedlmeier, AM, Leitzmann, MF, Rohrmann, S, Kühn, T, Jochem, C, Reger, C, Sedlmeier, AM, Leitzmann, MF, Rohrmann, S, and Kühn, T
Published: 2024

2. Sustainable diets and cancer: a systematic review

Author: Karavasiloglou, N, Pannen, S, Jochem, C, Kühn, T, Rohrmann, S, Karavasiloglou, N, Pannen, S, Jochem, C, Kühn, T, and Rohrmann, S
Published: 2023

3. Sustainable diets and cancer: a systematic review

Author: Karavasiloglou, N, Pannen, S, Jochem, C, Kühn, T, Rohrmann, S, Karavasiloglou, N, Pannen, S, Jochem, C, Kühn, T, and Rohrmann, S
Published: 2023

4. Metabolic Signatures of Healthy Lifestyle Patterns and Colorectal Cancer Risk in a European Cohort.

Author: Rothwell, JA, Murphy, N, Bešević, J, Kliemann, N, Jenab, M, Ferrari, P, Achaintre, D, Gicquiau, A, Vozar, B, Scalbert, A, Huybrechts, I, Freisling, H, Prehn, C, Adamski, J, Cross, AJ, Pala, VM, Boutron-Ruault, M-C, Dahm, CC, Overvad, K, Gram, IT, Sandanger, TM, Skeie, G, Jakszyn, P, Tsilidis, KK, Aleksandrova, K, Schulze, MB, Hughes, DJ, van Guelpen, B, Bodén, S, Sánchez, M-J, Schmidt, JA, Katzke, V, Kühn, T, Colorado-Yohar, S, Tumino, R, Bueno-de-Mesquita, B, Vineis, P, Masala, G, Panico, S, Eriksen, AK, Tjønneland, A, Aune, D, Weiderpass, E, Severi, G, Chajès, V, Gunter, MJ, Rothwell, JA, Murphy, N, Bešević, J, Kliemann, N, Jenab, M, Ferrari, P, Achaintre, D, Gicquiau, A, Vozar, B, Scalbert, A, Huybrechts, I, Freisling, H, Prehn, C, Adamski, J, Cross, AJ, Pala, VM, Boutron-Ruault, M-C, Dahm, CC, Overvad, K, Gram, IT, Sandanger, TM, Skeie, G, Jakszyn, P, Tsilidis, KK, Aleksandrova, K, Schulze, MB, Hughes, DJ, van Guelpen, B, Bodén, S, Sánchez, M-J, Schmidt, JA, Katzke, V, Kühn, T, Colorado-Yohar, S, Tumino, R, Bueno-de-Mesquita, B, Vineis, P, Masala, G, Panico, S, Eriksen, AK, Tjønneland, A, Aune, D, Weiderpass, E, Severi, G, Chajès, V, and Gunter, MJ
Abstract: BACKGROUND & AIMS: Colorectal cancer risk can be lowered by adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) guidelines. We derived metabolic signatures of adherence to these guidelines and tested their associations with colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort. METHODS: Scores reflecting adherence to the WCRF/AICR recommendations (scale, 1-5) were calculated from participant data on weight maintenance, physical activity, diet, and alcohol among a discovery set of 5738 cancer-free European Prospective Investigation into Cancer and Nutrition participants with metabolomics data. Partial least-squares regression was used to derive fatty acid and endogenous metabolite signatures of the WCRF/AICR score in this group. In an independent set of 1608 colorectal cancer cases and matched controls, odds ratios (ORs) and 95% CIs were calculated for colorectal cancer risk per unit increase in WCRF/AICR score and per the corresponding change in metabolic signatures using multivariable conditional logistic regression. RESULTS: Higher WCRF/AICR scores were characterized by metabolic signatures of increased odd-chain fatty acids, serine, glycine, and specific phosphatidylcholines. Signatures were inversely associated more strongly with colorectal cancer risk (fatty acids: OR, 0.51 per unit increase; 95% CI, 0.29-0.90; endogenous metabolites: OR, 0.62 per unit change; 95% CI, 0.50-0.78) than the WCRF/AICR score (OR, 0.93 per unit change; 95% CI, 0.86-1.00) overall. Signature associations were stronger in male compared with female participants. CONCLUSIONS: Metabolite profiles reflecting adherence to WCRF/AICR guidelines and additional lifestyle or biological risk factors were associated with colorectal cancer. Measuring a specific panel of metabolites representative of a healthy or unhealthy lifestyle may identify strata of the population at higher risk of colorectal cancer.
Published: 2022

5. Clean air policies are key for successfully mitigating Arctic warming

Author: von Salzen, K., Whaley, C.H., Anenberg, S.C., Van Dingenen, R., Klimont, Z., Flanner, M.G., Mahmood, R., Arnold, S.R., Beagley, S., Chien, R.-Y., Christensen, J.H., Eckhardt, S., Ekman, A.M.L., Evangeliou, N., Faluvegi, G., Fu, J.S., Gauss, M., Gong, W., Hjorth, J.L., Im, U., Krishnan, S., Kupiainen, K., Kühn, T., Langner, J., Law, K.S., Marelle, L., Olivié, D., Onishi, T., Oshima, N., Paunu, V.-V., Peng, Y., Plummer, D., Pozzoli, L., Rao, S., Raut, J.-C., Sand, M., Schmale, J., Sigmond, M., Thomas, M.A., Tsigaridis, K., Tsyro, S., Turnock, S.T., Wang, M., Winter, B., von Salzen, K., Whaley, C.H., Anenberg, S.C., Van Dingenen, R., Klimont, Z., Flanner, M.G., Mahmood, R., Arnold, S.R., Beagley, S., Chien, R.-Y., Christensen, J.H., Eckhardt, S., Ekman, A.M.L., Evangeliou, N., Faluvegi, G., Fu, J.S., Gauss, M., Gong, W., Hjorth, J.L., Im, U., Krishnan, S., Kupiainen, K., Kühn, T., Langner, J., Law, K.S., Marelle, L., Olivié, D., Onishi, T., Oshima, N., Paunu, V.-V., Peng, Y., Plummer, D., Pozzoli, L., Rao, S., Raut, J.-C., Sand, M., Schmale, J., Sigmond, M., Thomas, M.A., Tsigaridis, K., Tsyro, S., Turnock, S.T., Wang, M., and Winter, B.
Abstract: A tighter integration of modeling frameworks for climate and air quality is urgently needed to assess the impacts of clean air policies on future Arctic and global climate. We combined a new model emulator and comprehensive emissions scenarios for air pollutants and greenhouse gases to assess climate and human health co-benefits of emissions reductions. Fossil fuel use is projected to rapidly decline in an increasingly sustainable world, resulting in far-reaching air quality benefits. Despite human health benefits, reductions in sulfur emissions in a more sustainable world could enhance Arctic warming by 0.8 °C in 2050 relative to the 1995–2014, thereby offsetting climate benefits of greenhouse gas reductions. Targeted and technically feasible emissions reduction opportunities exist for achieving simultaneous climate and human health co-benefits. It would be particularly beneficial to unlock a newly identified mitigation potential for carbon particulate matter, yielding Arctic climate benefits equivalent to those from carbon dioxide reductions by 2050.
Published: 2022
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6. Clean air policies are key for successfully mitigating Arctic warming

Author: von Salzen, K., Whaley, C.H., Anenberg, S.C., Van Dingenen, R., Klimont, Z., Flanner, M.G., Mahmood, R., Arnold, S.R., Beagley, S., Chien, R.-Y., Christensen, J.H., Eckhardt, S., Ekman, A.M.L., Evangeliou, N., Faluvegi, G., Fu, J.S., Gauss, M., Gong, W., Hjorth, J.L., Im, U., Krishnan, S., Kupiainen, K., Kühn, T., Langner, J., Law, K.S., Marelle, L., Olivié, D., Onishi, T., Oshima, N., Paunu, V.-V., Peng, Y., Plummer, D., Pozzoli, L., Rao, S., Raut, J.-C., Sand, M., Schmale, J., Sigmond, M., Thomas, M.A., Tsigaridis, K., Tsyro, S., Turnock, S.T., Wang, M., Winter, B., von Salzen, K., Whaley, C.H., Anenberg, S.C., Van Dingenen, R., Klimont, Z., Flanner, M.G., Mahmood, R., Arnold, S.R., Beagley, S., Chien, R.-Y., Christensen, J.H., Eckhardt, S., Ekman, A.M.L., Evangeliou, N., Faluvegi, G., Fu, J.S., Gauss, M., Gong, W., Hjorth, J.L., Im, U., Krishnan, S., Kupiainen, K., Kühn, T., Langner, J., Law, K.S., Marelle, L., Olivié, D., Onishi, T., Oshima, N., Paunu, V.-V., Peng, Y., Plummer, D., Pozzoli, L., Rao, S., Raut, J.-C., Sand, M., Schmale, J., Sigmond, M., Thomas, M.A., Tsigaridis, K., Tsyro, S., Turnock, S.T., Wang, M., and Winter, B.
Abstract: A tighter integration of modeling frameworks for climate and air quality is urgently needed to assess the impacts of clean air policies on future Arctic and global climate. We combined a new model emulator and comprehensive emissions scenarios for air pollutants and greenhouse gases to assess climate and human health co-benefits of emissions reductions. Fossil fuel use is projected to rapidly decline in an increasingly sustainable world, resulting in far-reaching air quality benefits. Despite human health benefits, reductions in sulfur emissions in a more sustainable world could enhance Arctic warming by 0.8 °C in 2050 relative to the 1995–2014, thereby offsetting climate benefits of greenhouse gas reductions. Targeted and technically feasible emissions reduction opportunities exist for achieving simultaneous climate and human health co-benefits. It would be particularly beneficial to unlock a newly identified mitigation potential for carbon particulate matter, yielding Arctic climate benefits equivalent to those from carbon dioxide reductions by 2050.
Published: 2022
Full Text: View/download PDF

7. Clean air policies are key for successfully mitigating Arctic warming

Author: von Salzen, K., Whaley, C.H., Anenberg, S.C., Van Dingenen, R., Klimont, Z., Flanner, M.G., Mahmood, R., Arnold, S.R., Beagley, S., Chien, R.-Y., Christensen, J.H., Eckhardt, S., Ekman, A.M.L., Evangeliou, N., Faluvegi, G., Fu, J.S., Gauss, M., Gong, W., Hjorth, J.L., Im, U., Krishnan, S., Kupiainen, K., Kühn, T., Langner, J., Law, K.S., Marelle, L., Olivié, D., Onishi, T., Oshima, N., Paunu, V.-V., Peng, Y., Plummer, D., Pozzoli, L., Rao, S., Raut, J.-C., Sand, M., Schmale, J., Sigmond, M., Thomas, M.A., Tsigaridis, K., Tsyro, S., Turnock, S.T., Wang, M., Winter, B., von Salzen, K., Whaley, C.H., Anenberg, S.C., Van Dingenen, R., Klimont, Z., Flanner, M.G., Mahmood, R., Arnold, S.R., Beagley, S., Chien, R.-Y., Christensen, J.H., Eckhardt, S., Ekman, A.M.L., Evangeliou, N., Faluvegi, G., Fu, J.S., Gauss, M., Gong, W., Hjorth, J.L., Im, U., Krishnan, S., Kupiainen, K., Kühn, T., Langner, J., Law, K.S., Marelle, L., Olivié, D., Onishi, T., Oshima, N., Paunu, V.-V., Peng, Y., Plummer, D., Pozzoli, L., Rao, S., Raut, J.-C., Sand, M., Schmale, J., Sigmond, M., Thomas, M.A., Tsigaridis, K., Tsyro, S., Turnock, S.T., Wang, M., and Winter, B.
Abstract: A tighter integration of modeling frameworks for climate and air quality is urgently needed to assess the impacts of clean air policies on future Arctic and global climate. We combined a new model emulator and comprehensive emissions scenarios for air pollutants and greenhouse gases to assess climate and human health co-benefits of emissions reductions. Fossil fuel use is projected to rapidly decline in an increasingly sustainable world, resulting in far-reaching air quality benefits. Despite human health benefits, reductions in sulfur emissions in a more sustainable world could enhance Arctic warming by 0.8 °C in 2050 relative to the 1995–2014, thereby offsetting climate benefits of greenhouse gas reductions. Targeted and technically feasible emissions reduction opportunities exist for achieving simultaneous climate and human health co-benefits. It would be particularly beneficial to unlock a newly identified mitigation potential for carbon particulate matter, yielding Arctic climate benefits equivalent to those from carbon dioxide reductions by 2050.
Published: 2022
Full Text: View/download PDF

8. Metabolic perturbations prior to hepatocellular carcinoma diagnosis: Findings from a prospective observational cohort study

Author: IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Stepien, M., Keski-Rahkonen, P., Kiss, A., Robinot, N., Duarte-Salles, T., Murphy, N., Perlemuter, G., Viallon, V., Tjønneland, A., Rostgaard-Hansen, A.L., Dahm, C.C., Overvad, K., Boutron-Ruault, M.-C., Mancini, F.R., Mahamat-Saleh, Y., Aleksandrova, K., Kaaks, R., Kühn, T., Trichopoulou, A., Karakatsani, A., Panico, S., Tumino, R., Palli, D., Tagliabue, G., Naccarati, A., Vermeulen, R.C.H., Bueno-de-Mesquita, H.B., Weiderpass, E., Skeie, G., Ramón Quirós, J., Ardanaz, E., Mokoroa, O., Sala, N., Sánchez, M.-J., Huerta, J.M., Winkvist, A., Harlid, S., Ohlsson, B., Sjöberg, K., Wareham, N., Khaw, K.-T., Ferrari, P., Rothwell, J.A., Gunter, M., Riboli, E., Scalbert, A., Jenab, M., IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Stepien, M., Keski-Rahkonen, P., Kiss, A., Robinot, N., Duarte-Salles, T., Murphy, N., Perlemuter, G., Viallon, V., Tjønneland, A., Rostgaard-Hansen, A.L., Dahm, C.C., Overvad, K., Boutron-Ruault, M.-C., Mancini, F.R., Mahamat-Saleh, Y., Aleksandrova, K., Kaaks, R., Kühn, T., Trichopoulou, A., Karakatsani, A., Panico, S., Tumino, R., Palli, D., Tagliabue, G., Naccarati, A., Vermeulen, R.C.H., Bueno-de-Mesquita, H.B., Weiderpass, E., Skeie, G., Ramón Quirós, J., Ardanaz, E., Mokoroa, O., Sala, N., Sánchez, M.-J., Huerta, J.M., Winkvist, A., Harlid, S., Ohlsson, B., Sjöberg, K., Wareham, N., Khaw, K.-T., Ferrari, P., Rothwell, J.A., Gunter, M., Riboli, E., Scalbert, A., and Jenab, M.
Published: 2021

9. Associations between dietary amino acid intakes and blood concentration levels

Author: IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Iguacel, I., Perez-Cornago, A., Van Puyvelde, H., Travis, R., Stepien, M., Scalbert, A., Casagrande, C., Weiderpass, E., Riboli, E., Schulze, M.B., Skeie, G., Bodén, S., Boeing, H., Cross, A.J., Harlid, S., Jensen, T.E., Huerta, J.M., Katzke, V., Kühn, T., Lujan-Barroso, L., Masala, G., Rodriguez-Barranco, M., Rostgaard-Hansen, A.L., van der Schouw, Y.T., Vermeulen, R., Tagliabue, G., Tjønneland, A., Trevisan, M., Ferrari, P., Gunter, M.J., Huybrechts, I., IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Iguacel, I., Perez-Cornago, A., Van Puyvelde, H., Travis, R., Stepien, M., Scalbert, A., Casagrande, C., Weiderpass, E., Riboli, E., Schulze, M.B., Skeie, G., Bodén, S., Boeing, H., Cross, A.J., Harlid, S., Jensen, T.E., Huerta, J.M., Katzke, V., Kühn, T., Lujan-Barroso, L., Masala, G., Rodriguez-Barranco, M., Rostgaard-Hansen, A.L., van der Schouw, Y.T., Vermeulen, R., Tagliabue, G., Tjønneland, A., Trevisan, M., Ferrari, P., Gunter, M.J., and Huybrechts, I.
Published: 2021

10. Metabolic perturbations prior to hepatocellular carcinoma diagnosis: Findings from a prospective observational cohort study

Author: IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Stepien, M., Keski-Rahkonen, P., Kiss, A., Robinot, N., Duarte-Salles, T., Murphy, N., Perlemuter, G., Viallon, V., Tjønneland, A., Rostgaard-Hansen, A.L., Dahm, C.C., Overvad, K., Boutron-Ruault, M.-C., Mancini, F.R., Mahamat-Saleh, Y., Aleksandrova, K., Kaaks, R., Kühn, T., Trichopoulou, A., Karakatsani, A., Panico, S., Tumino, R., Palli, D., Tagliabue, G., Naccarati, A., Vermeulen, R.C.H., Bueno-de-Mesquita, H.B., Weiderpass, E., Skeie, G., Ramón Quirós, J., Ardanaz, E., Mokoroa, O., Sala, N., Sánchez, M.-J., Huerta, J.M., Winkvist, A., Harlid, S., Ohlsson, B., Sjöberg, K., Wareham, N., Khaw, K.-T., Ferrari, P., Rothwell, J.A., Gunter, M., Riboli, E., Scalbert, A., Jenab, M., IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Stepien, M., Keski-Rahkonen, P., Kiss, A., Robinot, N., Duarte-Salles, T., Murphy, N., Perlemuter, G., Viallon, V., Tjønneland, A., Rostgaard-Hansen, A.L., Dahm, C.C., Overvad, K., Boutron-Ruault, M.-C., Mancini, F.R., Mahamat-Saleh, Y., Aleksandrova, K., Kaaks, R., Kühn, T., Trichopoulou, A., Karakatsani, A., Panico, S., Tumino, R., Palli, D., Tagliabue, G., Naccarati, A., Vermeulen, R.C.H., Bueno-de-Mesquita, H.B., Weiderpass, E., Skeie, G., Ramón Quirós, J., Ardanaz, E., Mokoroa, O., Sala, N., Sánchez, M.-J., Huerta, J.M., Winkvist, A., Harlid, S., Ohlsson, B., Sjöberg, K., Wareham, N., Khaw, K.-T., Ferrari, P., Rothwell, J.A., Gunter, M., Riboli, E., Scalbert, A., and Jenab, M.
Published: 2021

11. Associations between dietary amino acid intakes and blood concentration levels

Author: IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Iguacel, I., Perez-Cornago, A., Van Puyvelde, H., Travis, R., Stepien, M., Scalbert, A., Casagrande, C., Weiderpass, E., Riboli, E., Schulze, M.B., Skeie, G., Bodén, S., Boeing, H., Cross, A.J., Harlid, S., Jensen, T.E., Huerta, J.M., Katzke, V., Kühn, T., Lujan-Barroso, L., Masala, G., Rodriguez-Barranco, M., Rostgaard-Hansen, A.L., van der Schouw, Y.T., Vermeulen, R., Tagliabue, G., Tjønneland, A., Trevisan, M., Ferrari, P., Gunter, M.J., Huybrechts, I., IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Iguacel, I., Perez-Cornago, A., Van Puyvelde, H., Travis, R., Stepien, M., Scalbert, A., Casagrande, C., Weiderpass, E., Riboli, E., Schulze, M.B., Skeie, G., Bodén, S., Boeing, H., Cross, A.J., Harlid, S., Jensen, T.E., Huerta, J.M., Katzke, V., Kühn, T., Lujan-Barroso, L., Masala, G., Rodriguez-Barranco, M., Rostgaard-Hansen, A.L., van der Schouw, Y.T., Vermeulen, R., Tagliabue, G., Tjønneland, A., Trevisan, M., Ferrari, P., Gunter, M.J., and Huybrechts, I.
Published: 2021

12. Metabolic perturbations prior to hepatocellular carcinoma diagnosis: Findings from a prospective observational cohort study

Author: IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Stepien, M., Keski-Rahkonen, P., Kiss, A., Robinot, N., Duarte-Salles, T., Murphy, N., Perlemuter, G., Viallon, V., Tjønneland, A., Rostgaard-Hansen, A.L., Dahm, C.C., Overvad, K., Boutron-Ruault, M.-C., Mancini, F.R., Mahamat-Saleh, Y., Aleksandrova, K., Kaaks, R., Kühn, T., Trichopoulou, A., Karakatsani, A., Panico, S., Tumino, R., Palli, D., Tagliabue, G., Naccarati, A., Vermeulen, R.C.H., Bueno-de-Mesquita, H.B., Weiderpass, E., Skeie, G., Ramón Quirós, J., Ardanaz, E., Mokoroa, O., Sala, N., Sánchez, M.-J., Huerta, J.M., Winkvist, A., Harlid, S., Ohlsson, B., Sjöberg, K., Wareham, N., Khaw, K.-T., Ferrari, P., Rothwell, J.A., Gunter, M., Riboli, E., Scalbert, A., Jenab, M., IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Stepien, M., Keski-Rahkonen, P., Kiss, A., Robinot, N., Duarte-Salles, T., Murphy, N., Perlemuter, G., Viallon, V., Tjønneland, A., Rostgaard-Hansen, A.L., Dahm, C.C., Overvad, K., Boutron-Ruault, M.-C., Mancini, F.R., Mahamat-Saleh, Y., Aleksandrova, K., Kaaks, R., Kühn, T., Trichopoulou, A., Karakatsani, A., Panico, S., Tumino, R., Palli, D., Tagliabue, G., Naccarati, A., Vermeulen, R.C.H., Bueno-de-Mesquita, H.B., Weiderpass, E., Skeie, G., Ramón Quirós, J., Ardanaz, E., Mokoroa, O., Sala, N., Sánchez, M.-J., Huerta, J.M., Winkvist, A., Harlid, S., Ohlsson, B., Sjöberg, K., Wareham, N., Khaw, K.-T., Ferrari, P., Rothwell, J.A., Gunter, M., Riboli, E., Scalbert, A., and Jenab, M.
Published: 2021

13. Associations between dietary amino acid intakes and blood concentration levels

Author: IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Iguacel, I., Perez-Cornago, A., Van Puyvelde, H., Travis, R., Stepien, M., Scalbert, A., Casagrande, C., Weiderpass, E., Riboli, E., Schulze, M.B., Skeie, G., Bodén, S., Boeing, H., Cross, A.J., Harlid, S., Jensen, T.E., Huerta, J.M., Katzke, V., Kühn, T., Lujan-Barroso, L., Masala, G., Rodriguez-Barranco, M., Rostgaard-Hansen, A.L., van der Schouw, Y.T., Vermeulen, R., Tagliabue, G., Tjønneland, A., Trevisan, M., Ferrari, P., Gunter, M.J., Huybrechts, I., IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Iguacel, I., Perez-Cornago, A., Van Puyvelde, H., Travis, R., Stepien, M., Scalbert, A., Casagrande, C., Weiderpass, E., Riboli, E., Schulze, M.B., Skeie, G., Bodén, S., Boeing, H., Cross, A.J., Harlid, S., Jensen, T.E., Huerta, J.M., Katzke, V., Kühn, T., Lujan-Barroso, L., Masala, G., Rodriguez-Barranco, M., Rostgaard-Hansen, A.L., van der Schouw, Y.T., Vermeulen, R., Tagliabue, G., Tjønneland, A., Trevisan, M., Ferrari, P., Gunter, M.J., and Huybrechts, I.
Published: 2021

14. Blood pressure and risk of cancer in the European Prospective Investigation into Cancer and Nutrition

Author: Christakoudi, S., Kakourou, A., Markozannes, G., Tzoulaki, I., Weiderpass, E., Brennan, P., Gunter, M., Dahm, C.C., Overvad, K., Olsen, A., Tjønneland, A., Boutron-Ruault, M.-C., Madika, A.-L., Severi, G., Katzke, V., Kühn, T., Bergmann, M.M., Boeing, H., Karakatsani, A., Martimianaki, G., Thriskos, P., Masala, G., Sieri, S., Panico, S., Tumino, R., Ricceri, F., Agudo, A., Redondo-Sánchez, D., Colorado-Yohar, S.M., Mokoroa, O., Melander, O., Stocks, T., Häggström, C., Harlid, S., Bueno-de-Mesquita, B., van Gils, C.H., Vermeulen, R.C.H., Khaw, K.-T., Wareham, N.J., Tong, T.Y.N., Freisling, H., Johansson, M., Lennon, H., Aune, D., Riboli, E., Trichopoulos, D., Trichopoulou, A., Tsilidis, K.K., Christakoudi, S., Kakourou, A., Markozannes, G., Tzoulaki, I., Weiderpass, E., Brennan, P., Gunter, M., Dahm, C.C., Overvad, K., Olsen, A., Tjønneland, A., Boutron-Ruault, M.-C., Madika, A.-L., Severi, G., Katzke, V., Kühn, T., Bergmann, M.M., Boeing, H., Karakatsani, A., Martimianaki, G., Thriskos, P., Masala, G., Sieri, S., Panico, S., Tumino, R., Ricceri, F., Agudo, A., Redondo-Sánchez, D., Colorado-Yohar, S.M., Mokoroa, O., Melander, O., Stocks, T., Häggström, C., Harlid, S., Bueno-de-Mesquita, B., van Gils, C.H., Vermeulen, R.C.H., Khaw, K.-T., Wareham, N.J., Tong, T.Y.N., Freisling, H., Johansson, M., Lennon, H., Aune, D., Riboli, E., Trichopoulos, D., Trichopoulou, A., and Tsilidis, K.K.
Abstract: Several studies have reported associations of hypertension with cancer, but not all results were conclusive. We examined the association of systolic (SBP) and diastolic (DBP) blood pressure with the development of incident cancer at all anatomical sites in the European Prospective Investigation into Cancer and Nutrition (EPIC). Hazard ratios (HRs) (95% confidence intervals) were estimated using multivariable Cox proportional hazards models, stratified by EPIC-participating center and age at recruitment, and adjusted for sex, education, smoking, body mass index, physical activity, diabetes and dietary (in women also reproductive) factors. The study included 307,318 men and women, with an average follow-up of 13.7 (standard deviation 4.4) years and 39,298 incident cancers. We confirmed the expected positive association with renal cell carcinoma: HR = 1.12 (1.08–1.17) per 10 mm Hg higher SBP and HR = 1.23 (1.14–1.32) for DBP. We additionally found positive associations for esophageal squamous cell carcinoma (SCC): HR = 1.16 (1.07–1.26) (SBP), HR = 1.31 (1.13–1.51) (DBP), weaker for head and neck cancers: HR = 1.08 (1.04–1.12) (SBP), HR = 1.09 (1.01–1.17) (DBP) and, similarly, for skin SCC, colon cancer, postmenopausal breast cancer and uterine adenocarcinoma (AC), but not for esophageal AC, lung SCC, lung AC or uterine endometroid cancer. We observed weak inverse associations of SBP with cervical SCC: HR = 0.91 (0.82–1.00) and lymphomas: HR = 0.97 (0.93–1.00). There were no consistent associations with cancers in other locations. Our results are largely compatible with published studies and support weak associations of blood pressure with cancers in specific locations and morphologies.
Published: 2020

15. Polyphenol intake and differentiated thyroid cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Author: Zamora-Ros, R., Cayssials, V., Franceschi, S., Kyrø, C., Weiderpass, E., Hennings, J., Sandström, M., Tjønneland, A., Olsen, A., Overvad, K., Boutron-Ruault, M.-C., Truong, T., Mancini, F.R., Katzke, V., Kühn, T., Boeing, H., Trichopoulou, A., Karakatsani, A., Martimianaki, G., Palli, D., Krogh, V., Panico, S., Tumino, R., Sacerdote, C., Lasheras, C., Rodríguez-Barranco, M., Amiano, P., Colorado-Yohar, S.M., Ardanaz, E., Almquist, M., Ericson, U., Bueno-de-Mesquita, H.B., Vermeulen, R., Byrnes, G., Scalbert, A., Agudo, A., Rinaldi, S., Zamora-Ros, R., Cayssials, V., Franceschi, S., Kyrø, C., Weiderpass, E., Hennings, J., Sandström, M., Tjønneland, A., Olsen, A., Overvad, K., Boutron-Ruault, M.-C., Truong, T., Mancini, F.R., Katzke, V., Kühn, T., Boeing, H., Trichopoulou, A., Karakatsani, A., Martimianaki, G., Palli, D., Krogh, V., Panico, S., Tumino, R., Sacerdote, C., Lasheras, C., Rodríguez-Barranco, M., Amiano, P., Colorado-Yohar, S.M., Ardanaz, E., Almquist, M., Ericson, U., Bueno-de-Mesquita, H.B., Vermeulen, R., Byrnes, G., Scalbert, A., Agudo, A., and Rinaldi, S.
Abstract: Polyphenols are bioactive compounds with several anticarcinogenic activities; however, human data regarding associations with thyroid cancer (TC) is still negligible. Our aim was to evaluate the association between intakes of total, classes and subclasses of polyphenols and risk of differentiated TC and its main subtypes, papillary and follicular, in a European population. The European Prospective Investigation into Cancer and Nutrition cohort included 476,108 men and women from 10 European countries. During a mean follow-up of 14 years, there were 748 incident differentiated TC cases, including 601 papillary and 109 follicular tumors. Polyphenol intake was estimated at baseline using validated center/country-specific dietary questionnaires and the Phenol-Explorer database. In multivariable-adjusted Cox regression models, no association between total polyphenol and the risks of overall differentiated TC (HRQ4 vs. Q1 = 0.99, 95% confidence interval [CI] 0.77–1.29), papillary (HRQ4 vs. Q1 = 1.06, 95% CI 0.80–1.41) or follicular TC (HRQ4 vs. Q1 = 1.10, 95% CI 0.55–2.22) were found. No associations were observed either for flavonoids, phenolic acids or the rest of classes and subclasses of polyphenols. After stratification by body mass index (BMI), an inverse association between the intake of polyphenols (p-trend = 0.019) and phenolic acids (p-trend = 0.007) and differentiated TC risk in subjects with BMI ≥ 25 was observed. In conclusion, our study showed no associations between dietary polyphenol intake and differentiated TC risk; although further studies are warranted to investigate the potential protective associations in overweight and obese individuals.
Published: 2020

16. Anthropometric and reproductive factors and risk of esophageal and gastric cancer by subtype and subsite: Results from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Author: Sanikini, H., Sophiea, M., Rinaldi, S., Agudo, A., Duell, E.J., Weiderpass, E., Overvad, K., Tjønneland, A., Halkjær, J., Boutron-Ruault, M.-C., Carbonnel, F., Cervenka, I., Boeing, H., Kaaks, R., Kühn, T., Trichopoulou, A., Martimianaki, G., Karakatsani, A., Pala, V., Palli, D., Mattiello, A., Tumino, R., Sacerdote, C., Skeie, G., Rylander, C., Chirlaque López, M.-D., Sánchez, M.-J., Ardanaz, E., Regnér, S., Stocks, T., Bueno-de-Mesquita, B., Vermeulen, R.C.H., Aune, D., Tong, T.Y.N., Kliemann, N., Murphy, N., Chadeau-Hyam, M., Gunter, M.J., Cross, A.J., Sanikini, H., Sophiea, M., Rinaldi, S., Agudo, A., Duell, E.J., Weiderpass, E., Overvad, K., Tjønneland, A., Halkjær, J., Boutron-Ruault, M.-C., Carbonnel, F., Cervenka, I., Boeing, H., Kaaks, R., Kühn, T., Trichopoulou, A., Martimianaki, G., Karakatsani, A., Pala, V., Palli, D., Mattiello, A., Tumino, R., Sacerdote, C., Skeie, G., Rylander, C., Chirlaque López, M.-D., Sánchez, M.-J., Ardanaz, E., Regnér, S., Stocks, T., Bueno-de-Mesquita, B., Vermeulen, R.C.H., Aune, D., Tong, T.Y.N., Kliemann, N., Murphy, N., Chadeau-Hyam, M., Gunter, M.J., and Cross, A.J.
Abstract: Obesity has been associated with upper gastrointestinal cancers; however, there are limited prospective data on associations by subtype/subsite. Obesity can impact hormonal factors, which have been hypothesized to play a role in these cancers. We investigated anthropometric and reproductive factors in relation to esophageal and gastric cancer by subtype and subsite for 476,160 participants from the European Prospective Investigation into Cancer and Nutrition cohort. Multivariable hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox models. During a mean follow-up of 14 years, 220 esophageal adenocarcinomas (EA), 195 esophageal squamous cell carcinomas, 243 gastric cardia (GC) and 373 gastric noncardia (GNC) cancers were diagnosed. Body mass index (BMI) was associated with EA in men (BMI ≥30 vs. 18.5–25 kg/m2: HR = 1.94, 95% CI: 1.25–3.03) and women (HR = 2.66, 95% CI: 1.15–6.19); however, adjustment for waist-to-hip ratio (WHR) attenuated these associations. After mutual adjustment for BMI and HC, respectively, WHR and waist circumference (WC) were associated with EA in men (HR = 3.47, 95% CI: 1.99–6.06 for WHR >0.96 vs. <0.91; HR = 2.67, 95% CI: 1.52–4.72 for WC >98 vs. <90 cm) and women (HR = 4.40, 95% CI: 1.35–14.33 for WHR >0.82 vs. <0.76; HR = 5.67, 95% CI: 1.76–18.26 for WC >84 vs. <74 cm). WHR was also positively associated with GC in women, and WC was positively associated with GC in men. Inverse associations were observed between parity and EA (HR = 0.38, 95% CI: 0.14–0.99; >2 vs. 0) and age at first pregnancy and GNC (HR = 0.54, 95% CI: 0.32–0.91; >26 vs. <22 years); whereas bilateral ovariectomy was positively associated with GNC (HR = 1.87, 95% CI: 1.04–3.36). These findings support a role for hormonal pathways in upper gastrointestinal cancers.
Published: 2020

17. Plasma polyphenols associated with lower high-sensitivity C-reactive protein concentrations: A cross-sectional study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Author: Harms, L.M., Scalbert, A., Zamora-Ros, R., Rinaldi, S., Jenab, M., Murphy, N., Achaintre, D., Tjønneland, A., Olsen, A., Overvad, K., Romana Mancini, F., Mahamat-Saleh, Y., Boutron-Ruault, M.-C., Kühn, T., Katzke, V., Trichopoulou, A., Martimianaki, G., Karakatsani, A., Palli, D., Panico, S., Sieri, S., Tumino, R., Sacerdote, C., Bueno-De-Mesquita, B., Vermeulen, R.C.H., Weiderpass, E., Nøst, T.H., Lasheras, C., Rodríguez-Barranco, M., Huerta, J.M., Barricarte, A., Dorronsoro, M., Hultdin, J., Gunter, M., Riboli, E., Aleksandrova, K., Harms, L.M., Scalbert, A., Zamora-Ros, R., Rinaldi, S., Jenab, M., Murphy, N., Achaintre, D., Tjønneland, A., Olsen, A., Overvad, K., Romana Mancini, F., Mahamat-Saleh, Y., Boutron-Ruault, M.-C., Kühn, T., Katzke, V., Trichopoulou, A., Martimianaki, G., Karakatsani, A., Palli, D., Panico, S., Sieri, S., Tumino, R., Sacerdote, C., Bueno-De-Mesquita, B., Vermeulen, R.C.H., Weiderpass, E., Nøst, T.H., Lasheras, C., Rodríguez-Barranco, M., Huerta, J.M., Barricarte, A., Dorronsoro, M., Hultdin, J., Gunter, M., Riboli, E., and Aleksandrova, K.
Abstract: Experimental studies have reported on the anti-inflammatory properties of polyphenols. However, results from epidemiological investigations have been inconsistent and especially studies using biomarkers for assessment of polyphenol intake have been scant. We aimed to characterise the association between plasma concentrations of thirty-five polyphenol compounds and low-grade systemic inflammation state as measured by high-sensitivity C-reactive protein (hsCRP). A cross-sectional data analysis was performed based on 315 participants in the European Prospective Investigation into Cancer and Nutrition cohort with available measurements of plasma polyphenols and hsCRP. In logistic regression analysis, the OR and 95 % CI of elevated serum hsCRP (>3 mg/l) were calculated within quartiles and per standard deviation higher level of plasma polyphenol concentrations. In a multivariable-adjusted model, the sum of plasma concentrations of all polyphenols measured (per standard deviation) was associated with 29 (95 % CI 50, 1) % lower odds of elevated hsCRP. In the class of flavonoids, daidzein was inversely associated with elevated hsCRP (OR 0·66, 95 % CI 0·46, 0·96). Among phenolic acids, statistically significant associations were observed for 3,5-dihydroxyphenylpropionic acid (OR 0·58, 95 % CI 0·39, 0·86), 3,4-dihydroxyphenylpropionic acid (OR 0·63, 95 % CI 0·46, 0·87), ferulic acid (OR 0·65, 95 % CI 0·44, 0·96) and caffeic acid (OR 0·69, 95 % CI 0·51, 0·93). The odds of elevated hsCRP were significantly reduced for hydroxytyrosol (OR 0·67, 95 % CI 0·48, 0·93). The present study showed that polyphenol biomarkers are associated with lower odds of elevated hsCRP. Whether diet rich in bioactive polyphenol compounds could be an effective strategy to prevent or modulate deleterious health effects of inflammation should be addressed by further well-powered longitudinal studies.
Published: 2020

18. Consumption of nuts and seeds and pancreatic ductal adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition

Author: Obón-Santacana, M., Luján-Barroso, L., Freisling, H., Naudin, S., Boutron-Ruault, M.-C., Mancini, F.R., Rebours, V., Kühn, T., Katzke, V., Boeing, H., Tjønneland, A., Olsen, A., Overvad, K., Lasheras, C., Rodríguez-Barranco, M., Amiano, P., Santiuste, C., Ardanaz, E., Khaw, K.-T., Wareham, N.J., Aune, D., Trichopoulou, A., Thriskos, P., Peppa, E., Masala, G., Grioni, S., Tumino, R., Panico, S., Bueno-de-Mesquita, B., Sciannameo, V., Vermeulen, R., Sonestedt, E., Sund, M., Weiderpass, E., Skeie, G., Riboli, E., Duell, E.J., Obón-Santacana, M., Luján-Barroso, L., Freisling, H., Naudin, S., Boutron-Ruault, M.-C., Mancini, F.R., Rebours, V., Kühn, T., Katzke, V., Boeing, H., Tjønneland, A., Olsen, A., Overvad, K., Lasheras, C., Rodríguez-Barranco, M., Amiano, P., Santiuste, C., Ardanaz, E., Khaw, K.-T., Wareham, N.J., Aune, D., Trichopoulou, A., Thriskos, P., Peppa, E., Masala, G., Grioni, S., Tumino, R., Panico, S., Bueno-de-Mesquita, B., Sciannameo, V., Vermeulen, R., Sonestedt, E., Sund, M., Weiderpass, E., Skeie, G., Riboli, E., and Duell, E.J.
Abstract: Four epidemiologic studies have assessed the association between nut intake and pancreatic cancer risk with contradictory results. The present study aims to investigate the relation between nut intake (including seeds) and pancreatic ductal adenocarcinoma (PDAC) risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Cox proportional hazards models were used to estimate hazards ratio (HR) and 95% confidence intervals (95% CI) for nut intake and PDAC risk. Information on intake of nuts was obtained from the EPIC country-specific dietary questionnaires. After a mean follow-up of 14 years, 476,160 participants were eligible for the present study and included 1,283 PDAC cases. No association was observed between consumption of nuts and PDAC risk (highest intake vs nonconsumers: HR, 0.89; 95% CI, 0.72–1.10; p-trend = 0.70). Furthermore, no evidence for effect-measure modification was observed when different subgroups were analyzed. Overall, in EPIC, the highest intake of nuts was not statistically significantly associated with PDAC risk.
Published: 2020

19. A metabolomic study of red and processed meat intake and acylcarnitine concentrations in human urine and blood

Author: Wedekind, R., Kiss, A., Keski-Rahkonen, P., Viallon, V., Rothwell, J.A., Cross, A.J., Rostgaard-Hansen, A.L., Sandanger, T.M., Jakszyn, P., Pala, V., Vermeulen, R., Schulze, M.B., Kühn, T., Johnson, T., Trichopoulou, A., Peppa, E., Vechia, C.L., Masala, G., Tumino, R., Sacerdote, C., Wittenbecher, C., de Magistris, M.S., Dahm, C.C., Severi, G., Mancini, F.R., Weiderpass, E., Gunter, M.J., Huybrechts, I., Scalbert, A., Wedekind, R., Kiss, A., Keski-Rahkonen, P., Viallon, V., Rothwell, J.A., Cross, A.J., Rostgaard-Hansen, A.L., Sandanger, T.M., Jakszyn, P., Pala, V., Vermeulen, R., Schulze, M.B., Kühn, T., Johnson, T., Trichopoulou, A., Peppa, E., Vechia, C.L., Masala, G., Tumino, R., Sacerdote, C., Wittenbecher, C., de Magistris, M.S., Dahm, C.C., Severi, G., Mancini, F.R., Weiderpass, E., Gunter, M.J., Huybrechts, I., and Scalbert, A.
Abstract: Background Acylcarnitines (ACs) play a major role in fatty acid metabolism and are potential markers of metabolic dysfunction with higher blood concentrations reported in obese and diabetic individuals. Diet, and in particular red and processed meat intake, has been shown to influence AC concentrations but data on the effect of meat consumption on AC concentrations is limited. Objectives To investigate the effect of red and processed meat intake on AC concentrations in plasma and urine using a randomized controlled trial with replication in an observational cohort. Methods In the randomized crossover trial, 12 volunteers successively consumed 2 different diets containing either pork or tofu for 3 d each. A panel of 44 ACs including several oxidized ACs was analyzed by LC-MS in plasma and urine samples collected after the 3-d period. ACs that were associated with pork intake were then measured in urine (n = 474) and serum samples (n = 451) from the European Prospective Investigation into Cancer and nutrition (EPIC) study and tested for associations with habitual red and processed meat intake derived from dietary questionnaires. Results In urine samples from the intervention study, pork intake was positively associated with concentrations of 18 short- and medium-chain ACs. Eleven of these were also positively associated with habitual red and processed meat intake in the EPIC cross-sectional study. In blood, C18:0 was positively associated with red meat intake in both the intervention study (q = 0.004, Student's t-test) and the cross-sectional study (q = 0.033, linear regression). Conclusions AC concentrations in urine and blood were associated with red meat intake in both a highly controlled intervention study and in subjects of a cross-sectional study. Our data on the role of meat intake on this important pathway of fatty acid and energy metabolism may help understanding the role of red meat consumption in the e
Published: 2020

20. Polyphenol intake and differentiated thyroid cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Author: IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Zamora-Ros, R., Cayssials, V., Franceschi, S., Kyrø, C., Weiderpass, E., Hennings, J., Sandström, M., Tjønneland, A., Olsen, A., Overvad, K., Boutron-Ruault, M.-C., Truong, T., Mancini, F.R., Katzke, V., Kühn, T., Boeing, H., Trichopoulou, A., Karakatsani, A., Martimianaki, G., Palli, D., Krogh, V., Panico, S., Tumino, R., Sacerdote, C., Lasheras, C., Rodríguez-Barranco, M., Amiano, P., Colorado-Yohar, S.M., Ardanaz, E., Almquist, M., Ericson, U., Bueno-de-Mesquita, H.B., Vermeulen, R., Byrnes, G., Scalbert, A., Agudo, A., Rinaldi, S., IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Zamora-Ros, R., Cayssials, V., Franceschi, S., Kyrø, C., Weiderpass, E., Hennings, J., Sandström, M., Tjønneland, A., Olsen, A., Overvad, K., Boutron-Ruault, M.-C., Truong, T., Mancini, F.R., Katzke, V., Kühn, T., Boeing, H., Trichopoulou, A., Karakatsani, A., Martimianaki, G., Palli, D., Krogh, V., Panico, S., Tumino, R., Sacerdote, C., Lasheras, C., Rodríguez-Barranco, M., Amiano, P., Colorado-Yohar, S.M., Ardanaz, E., Almquist, M., Ericson, U., Bueno-de-Mesquita, H.B., Vermeulen, R., Byrnes, G., Scalbert, A., Agudo, A., and Rinaldi, S.
Published: 2020

21. A metabolomic study of red and processed meat intake and acylcarnitine concentrations in human urine and blood

Author: IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Wedekind, R., Kiss, A., Keski-Rahkonen, P., Viallon, V., Rothwell, J.A., Cross, A.J., Rostgaard-Hansen, A.L., Sandanger, T.M., Jakszyn, P., Pala, V., Vermeulen, R., Schulze, M.B., Kühn, T., Johnson, T., Trichopoulou, A., Peppa, E., Vechia, C.L., Masala, G., Tumino, R., Sacerdote, C., Wittenbecher, C., de Magistris, M.S., Dahm, C.C., Severi, G., Mancini, F.R., Weiderpass, E., Gunter, M.J., Huybrechts, I., Scalbert, A., IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Wedekind, R., Kiss, A., Keski-Rahkonen, P., Viallon, V., Rothwell, J.A., Cross, A.J., Rostgaard-Hansen, A.L., Sandanger, T.M., Jakszyn, P., Pala, V., Vermeulen, R., Schulze, M.B., Kühn, T., Johnson, T., Trichopoulou, A., Peppa, E., Vechia, C.L., Masala, G., Tumino, R., Sacerdote, C., Wittenbecher, C., de Magistris, M.S., Dahm, C.C., Severi, G., Mancini, F.R., Weiderpass, E., Gunter, M.J., Huybrechts, I., and Scalbert, A.
Published: 2020

22. Anthropometric and reproductive factors and risk of esophageal and gastric cancer by subtype and subsite: Results from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Author: IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Sanikini, H., Sophiea, M., Rinaldi, S., Agudo, A., Duell, E.J., Weiderpass, E., Overvad, K., Tjønneland, A., Halkjær, J., Boutron-Ruault, M.-C., Carbonnel, F., Cervenka, I., Boeing, H., Kaaks, R., Kühn, T., Trichopoulou, A., Martimianaki, G., Karakatsani, A., Pala, V., Palli, D., Mattiello, A., Tumino, R., Sacerdote, C., Skeie, G., Rylander, C., Chirlaque López, M.-D., Sánchez, M.-J., Ardanaz, E., Regnér, S., Stocks, T., Bueno-de-Mesquita, B., Vermeulen, R.C.H., Aune, D., Tong, T.Y.N., Kliemann, N., Murphy, N., Chadeau-Hyam, M., Gunter, M.J., Cross, A.J., IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Sanikini, H., Sophiea, M., Rinaldi, S., Agudo, A., Duell, E.J., Weiderpass, E., Overvad, K., Tjønneland, A., Halkjær, J., Boutron-Ruault, M.-C., Carbonnel, F., Cervenka, I., Boeing, H., Kaaks, R., Kühn, T., Trichopoulou, A., Martimianaki, G., Karakatsani, A., Pala, V., Palli, D., Mattiello, A., Tumino, R., Sacerdote, C., Skeie, G., Rylander, C., Chirlaque López, M.-D., Sánchez, M.-J., Ardanaz, E., Regnér, S., Stocks, T., Bueno-de-Mesquita, B., Vermeulen, R.C.H., Aune, D., Tong, T.Y.N., Kliemann, N., Murphy, N., Chadeau-Hyam, M., Gunter, M.J., and Cross, A.J.
Published: 2020

23. Consumption of nuts and seeds and pancreatic ductal adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition

Author: IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Obón-Santacana, M., Luján-Barroso, L., Freisling, H., Naudin, S., Boutron-Ruault, M.-C., Mancini, F.R., Rebours, V., Kühn, T., Katzke, V., Boeing, H., Tjønneland, A., Olsen, A., Overvad, K., Lasheras, C., Rodríguez-Barranco, M., Amiano, P., Santiuste, C., Ardanaz, E., Khaw, K.-T., Wareham, N.J., Aune, D., Trichopoulou, A., Thriskos, P., Peppa, E., Masala, G., Grioni, S., Tumino, R., Panico, S., Bueno-de-Mesquita, B., Sciannameo, V., Vermeulen, R., Sonestedt, E., Sund, M., Weiderpass, E., Skeie, G., Riboli, E., Duell, E.J., IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Obón-Santacana, M., Luján-Barroso, L., Freisling, H., Naudin, S., Boutron-Ruault, M.-C., Mancini, F.R., Rebours, V., Kühn, T., Katzke, V., Boeing, H., Tjønneland, A., Olsen, A., Overvad, K., Lasheras, C., Rodríguez-Barranco, M., Amiano, P., Santiuste, C., Ardanaz, E., Khaw, K.-T., Wareham, N.J., Aune, D., Trichopoulou, A., Thriskos, P., Peppa, E., Masala, G., Grioni, S., Tumino, R., Panico, S., Bueno-de-Mesquita, B., Sciannameo, V., Vermeulen, R., Sonestedt, E., Sund, M., Weiderpass, E., Skeie, G., Riboli, E., and Duell, E.J.
Published: 2020

24. Plasma polyphenols associated with lower high-sensitivity C-reactive protein concentrations: A cross-sectional study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Author: IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Harms, L.M., Scalbert, A., Zamora-Ros, R., Rinaldi, S., Jenab, M., Murphy, N., Achaintre, D., Tjønneland, A., Olsen, A., Overvad, K., Romana Mancini, F., Mahamat-Saleh, Y., Boutron-Ruault, M.-C., Kühn, T., Katzke, V., Trichopoulou, A., Martimianaki, G., Karakatsani, A., Palli, D., Panico, S., Sieri, S., Tumino, R., Sacerdote, C., Bueno-De-Mesquita, B., Vermeulen, R.C.H., Weiderpass, E., Nøst, T.H., Lasheras, C., Rodríguez-Barranco, M., Huerta, J.M., Barricarte, A., Dorronsoro, M., Hultdin, J., Gunter, M., Riboli, E., Aleksandrova, K., IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Harms, L.M., Scalbert, A., Zamora-Ros, R., Rinaldi, S., Jenab, M., Murphy, N., Achaintre, D., Tjønneland, A., Olsen, A., Overvad, K., Romana Mancini, F., Mahamat-Saleh, Y., Boutron-Ruault, M.-C., Kühn, T., Katzke, V., Trichopoulou, A., Martimianaki, G., Karakatsani, A., Palli, D., Panico, S., Sieri, S., Tumino, R., Sacerdote, C., Bueno-De-Mesquita, B., Vermeulen, R.C.H., Weiderpass, E., Nøst, T.H., Lasheras, C., Rodríguez-Barranco, M., Huerta, J.M., Barricarte, A., Dorronsoro, M., Hultdin, J., Gunter, M., Riboli, E., and Aleksandrova, K.
Published: 2020

25. Blood pressure and risk of cancer in the European Prospective Investigation into Cancer and Nutrition

Author: IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Christakoudi, S., Kakourou, A., Markozannes, G., Tzoulaki, I., Weiderpass, E., Brennan, P., Gunter, M., Dahm, C.C., Overvad, K., Olsen, A., Tjønneland, A., Boutron-Ruault, M.-C., Madika, A.-L., Severi, G., Katzke, V., Kühn, T., Bergmann, M.M., Boeing, H., Karakatsani, A., Martimianaki, G., Thriskos, P., Masala, G., Sieri, S., Panico, S., Tumino, R., Ricceri, F., Agudo, A., Redondo-Sánchez, D., Colorado-Yohar, S.M., Mokoroa, O., Melander, O., Stocks, T., Häggström, C., Harlid, S., Bueno-de-Mesquita, B., van Gils, C.H., Vermeulen, R.C.H., Khaw, K.-T., Wareham, N.J., Tong, T.Y.N., Freisling, H., Johansson, M., Lennon, H., Aune, D., Riboli, E., Trichopoulos, D., Trichopoulou, A., Tsilidis, K.K., IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Christakoudi, S., Kakourou, A., Markozannes, G., Tzoulaki, I., Weiderpass, E., Brennan, P., Gunter, M., Dahm, C.C., Overvad, K., Olsen, A., Tjønneland, A., Boutron-Ruault, M.-C., Madika, A.-L., Severi, G., Katzke, V., Kühn, T., Bergmann, M.M., Boeing, H., Karakatsani, A., Martimianaki, G., Thriskos, P., Masala, G., Sieri, S., Panico, S., Tumino, R., Ricceri, F., Agudo, A., Redondo-Sánchez, D., Colorado-Yohar, S.M., Mokoroa, O., Melander, O., Stocks, T., Häggström, C., Harlid, S., Bueno-de-Mesquita, B., van Gils, C.H., Vermeulen, R.C.H., Khaw, K.-T., Wareham, N.J., Tong, T.Y.N., Freisling, H., Johansson, M., Lennon, H., Aune, D., Riboli, E., Trichopoulos, D., Trichopoulou, A., and Tsilidis, K.K.
Published: 2020

26. Consumption of nuts and seeds and pancreatic ductal adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition

Author: IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Obón-Santacana, M., Luján-Barroso, L., Freisling, H., Naudin, S., Boutron-Ruault, M.-C., Mancini, F.R., Rebours, V., Kühn, T., Katzke, V., Boeing, H., Tjønneland, A., Olsen, A., Overvad, K., Lasheras, C., Rodríguez-Barranco, M., Amiano, P., Santiuste, C., Ardanaz, E., Khaw, K.-T., Wareham, N.J., Aune, D., Trichopoulou, A., Thriskos, P., Peppa, E., Masala, G., Grioni, S., Tumino, R., Panico, S., Bueno-de-Mesquita, B., Sciannameo, V., Vermeulen, R., Sonestedt, E., Sund, M., Weiderpass, E., Skeie, G., Riboli, E., Duell, E.J., IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Obón-Santacana, M., Luján-Barroso, L., Freisling, H., Naudin, S., Boutron-Ruault, M.-C., Mancini, F.R., Rebours, V., Kühn, T., Katzke, V., Boeing, H., Tjønneland, A., Olsen, A., Overvad, K., Lasheras, C., Rodríguez-Barranco, M., Amiano, P., Santiuste, C., Ardanaz, E., Khaw, K.-T., Wareham, N.J., Aune, D., Trichopoulou, A., Thriskos, P., Peppa, E., Masala, G., Grioni, S., Tumino, R., Panico, S., Bueno-de-Mesquita, B., Sciannameo, V., Vermeulen, R., Sonestedt, E., Sund, M., Weiderpass, E., Skeie, G., Riboli, E., and Duell, E.J.
Published: 2020

27. Anthropometric and reproductive factors and risk of esophageal and gastric cancer by subtype and subsite: Results from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Author: IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Sanikini, H., Sophiea, M., Rinaldi, S., Agudo, A., Duell, E.J., Weiderpass, E., Overvad, K., Tjønneland, A., Halkjær, J., Boutron-Ruault, M.-C., Carbonnel, F., Cervenka, I., Boeing, H., Kaaks, R., Kühn, T., Trichopoulou, A., Martimianaki, G., Karakatsani, A., Pala, V., Palli, D., Mattiello, A., Tumino, R., Sacerdote, C., Skeie, G., Rylander, C., Chirlaque López, M.-D., Sánchez, M.-J., Ardanaz, E., Regnér, S., Stocks, T., Bueno-de-Mesquita, B., Vermeulen, R.C.H., Aune, D., Tong, T.Y.N., Kliemann, N., Murphy, N., Chadeau-Hyam, M., Gunter, M.J., Cross, A.J., IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Sanikini, H., Sophiea, M., Rinaldi, S., Agudo, A., Duell, E.J., Weiderpass, E., Overvad, K., Tjønneland, A., Halkjær, J., Boutron-Ruault, M.-C., Carbonnel, F., Cervenka, I., Boeing, H., Kaaks, R., Kühn, T., Trichopoulou, A., Martimianaki, G., Karakatsani, A., Pala, V., Palli, D., Mattiello, A., Tumino, R., Sacerdote, C., Skeie, G., Rylander, C., Chirlaque López, M.-D., Sánchez, M.-J., Ardanaz, E., Regnér, S., Stocks, T., Bueno-de-Mesquita, B., Vermeulen, R.C.H., Aune, D., Tong, T.Y.N., Kliemann, N., Murphy, N., Chadeau-Hyam, M., Gunter, M.J., and Cross, A.J.
Published: 2020

28. Polyphenol intake and differentiated thyroid cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Author: IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Zamora-Ros, R., Cayssials, V., Franceschi, S., Kyrø, C., Weiderpass, E., Hennings, J., Sandström, M., Tjønneland, A., Olsen, A., Overvad, K., Boutron-Ruault, M.-C., Truong, T., Mancini, F.R., Katzke, V., Kühn, T., Boeing, H., Trichopoulou, A., Karakatsani, A., Martimianaki, G., Palli, D., Krogh, V., Panico, S., Tumino, R., Sacerdote, C., Lasheras, C., Rodríguez-Barranco, M., Amiano, P., Colorado-Yohar, S.M., Ardanaz, E., Almquist, M., Ericson, U., Bueno-de-Mesquita, H.B., Vermeulen, R., Byrnes, G., Scalbert, A., Agudo, A., Rinaldi, S., IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Zamora-Ros, R., Cayssials, V., Franceschi, S., Kyrø, C., Weiderpass, E., Hennings, J., Sandström, M., Tjønneland, A., Olsen, A., Overvad, K., Boutron-Ruault, M.-C., Truong, T., Mancini, F.R., Katzke, V., Kühn, T., Boeing, H., Trichopoulou, A., Karakatsani, A., Martimianaki, G., Palli, D., Krogh, V., Panico, S., Tumino, R., Sacerdote, C., Lasheras, C., Rodríguez-Barranco, M., Amiano, P., Colorado-Yohar, S.M., Ardanaz, E., Almquist, M., Ericson, U., Bueno-de-Mesquita, H.B., Vermeulen, R., Byrnes, G., Scalbert, A., Agudo, A., and Rinaldi, S.
Published: 2020

29. Blood pressure and risk of cancer in the European Prospective Investigation into Cancer and Nutrition

Author: IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Christakoudi, S., Kakourou, A., Markozannes, G., Tzoulaki, I., Weiderpass, E., Brennan, P., Gunter, M., Dahm, C.C., Overvad, K., Olsen, A., Tjønneland, A., Boutron-Ruault, M.-C., Madika, A.-L., Severi, G., Katzke, V., Kühn, T., Bergmann, M.M., Boeing, H., Karakatsani, A., Martimianaki, G., Thriskos, P., Masala, G., Sieri, S., Panico, S., Tumino, R., Ricceri, F., Agudo, A., Redondo-Sánchez, D., Colorado-Yohar, S.M., Mokoroa, O., Melander, O., Stocks, T., Häggström, C., Harlid, S., Bueno-de-Mesquita, B., van Gils, C.H., Vermeulen, R.C.H., Khaw, K.-T., Wareham, N.J., Tong, T.Y.N., Freisling, H., Johansson, M., Lennon, H., Aune, D., Riboli, E., Trichopoulos, D., Trichopoulou, A., Tsilidis, K.K., IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Christakoudi, S., Kakourou, A., Markozannes, G., Tzoulaki, I., Weiderpass, E., Brennan, P., Gunter, M., Dahm, C.C., Overvad, K., Olsen, A., Tjønneland, A., Boutron-Ruault, M.-C., Madika, A.-L., Severi, G., Katzke, V., Kühn, T., Bergmann, M.M., Boeing, H., Karakatsani, A., Martimianaki, G., Thriskos, P., Masala, G., Sieri, S., Panico, S., Tumino, R., Ricceri, F., Agudo, A., Redondo-Sánchez, D., Colorado-Yohar, S.M., Mokoroa, O., Melander, O., Stocks, T., Häggström, C., Harlid, S., Bueno-de-Mesquita, B., van Gils, C.H., Vermeulen, R.C.H., Khaw, K.-T., Wareham, N.J., Tong, T.Y.N., Freisling, H., Johansson, M., Lennon, H., Aune, D., Riboli, E., Trichopoulos, D., Trichopoulou, A., and Tsilidis, K.K.
Published: 2020

30. A metabolomic study of red and processed meat intake and acylcarnitine concentrations in human urine and blood

Author: IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Wedekind, R., Kiss, A., Keski-Rahkonen, P., Viallon, V., Rothwell, J.A., Cross, A.J., Rostgaard-Hansen, A.L., Sandanger, T.M., Jakszyn, P., Pala, V., Vermeulen, R., Schulze, M.B., Kühn, T., Johnson, T., Trichopoulou, A., Peppa, E., Vechia, C.L., Masala, G., Tumino, R., Sacerdote, C., Wittenbecher, C., de Magistris, M.S., Dahm, C.C., Severi, G., Mancini, F.R., Weiderpass, E., Gunter, M.J., Huybrechts, I., Scalbert, A., IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Wedekind, R., Kiss, A., Keski-Rahkonen, P., Viallon, V., Rothwell, J.A., Cross, A.J., Rostgaard-Hansen, A.L., Sandanger, T.M., Jakszyn, P., Pala, V., Vermeulen, R., Schulze, M.B., Kühn, T., Johnson, T., Trichopoulou, A., Peppa, E., Vechia, C.L., Masala, G., Tumino, R., Sacerdote, C., Wittenbecher, C., de Magistris, M.S., Dahm, C.C., Severi, G., Mancini, F.R., Weiderpass, E., Gunter, M.J., Huybrechts, I., and Scalbert, A.
Published: 2020

31. Plasma polyphenols associated with lower high-sensitivity C-reactive protein concentrations: A cross-sectional study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Author: IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Harms, L.M., Scalbert, A., Zamora-Ros, R., Rinaldi, S., Jenab, M., Murphy, N., Achaintre, D., Tjønneland, A., Olsen, A., Overvad, K., Romana Mancini, F., Mahamat-Saleh, Y., Boutron-Ruault, M.-C., Kühn, T., Katzke, V., Trichopoulou, A., Martimianaki, G., Karakatsani, A., Palli, D., Panico, S., Sieri, S., Tumino, R., Sacerdote, C., Bueno-De-Mesquita, B., Vermeulen, R.C.H., Weiderpass, E., Nøst, T.H., Lasheras, C., Rodríguez-Barranco, M., Huerta, J.M., Barricarte, A., Dorronsoro, M., Hultdin, J., Gunter, M., Riboli, E., Aleksandrova, K., IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Harms, L.M., Scalbert, A., Zamora-Ros, R., Rinaldi, S., Jenab, M., Murphy, N., Achaintre, D., Tjønneland, A., Olsen, A., Overvad, K., Romana Mancini, F., Mahamat-Saleh, Y., Boutron-Ruault, M.-C., Kühn, T., Katzke, V., Trichopoulou, A., Martimianaki, G., Karakatsani, A., Palli, D., Panico, S., Sieri, S., Tumino, R., Sacerdote, C., Bueno-De-Mesquita, B., Vermeulen, R.C.H., Weiderpass, E., Nøst, T.H., Lasheras, C., Rodríguez-Barranco, M., Huerta, J.M., Barricarte, A., Dorronsoro, M., Hultdin, J., Gunter, M., Riboli, E., and Aleksandrova, K.
Published: 2020

32. A metabolomic study of red and processed meat intake and acylcarnitine concentrations in human urine and blood

Author: IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Wedekind, R., Kiss, A., Keski-Rahkonen, P., Viallon, V., Rothwell, J.A., Cross, A.J., Rostgaard-Hansen, A.L., Sandanger, T.M., Jakszyn, P., Pala, V., Vermeulen, R., Schulze, M.B., Kühn, T., Johnson, T., Trichopoulou, A., Peppa, E., Vechia, C.L., Masala, G., Tumino, R., Sacerdote, C., Wittenbecher, C., de Magistris, M.S., Dahm, C.C., Severi, G., Mancini, F.R., Weiderpass, E., Gunter, M.J., Huybrechts, I., Scalbert, A., IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Wedekind, R., Kiss, A., Keski-Rahkonen, P., Viallon, V., Rothwell, J.A., Cross, A.J., Rostgaard-Hansen, A.L., Sandanger, T.M., Jakszyn, P., Pala, V., Vermeulen, R., Schulze, M.B., Kühn, T., Johnson, T., Trichopoulou, A., Peppa, E., Vechia, C.L., Masala, G., Tumino, R., Sacerdote, C., Wittenbecher, C., de Magistris, M.S., Dahm, C.C., Severi, G., Mancini, F.R., Weiderpass, E., Gunter, M.J., Huybrechts, I., and Scalbert, A.
Published: 2020

33. Polyphenol intake and differentiated thyroid cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Author: IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Zamora-Ros, R., Cayssials, V., Franceschi, S., Kyrø, C., Weiderpass, E., Hennings, J., Sandström, M., Tjønneland, A., Olsen, A., Overvad, K., Boutron-Ruault, M.-C., Truong, T., Mancini, F.R., Katzke, V., Kühn, T., Boeing, H., Trichopoulou, A., Karakatsani, A., Martimianaki, G., Palli, D., Krogh, V., Panico, S., Tumino, R., Sacerdote, C., Lasheras, C., Rodríguez-Barranco, M., Amiano, P., Colorado-Yohar, S.M., Ardanaz, E., Almquist, M., Ericson, U., Bueno-de-Mesquita, H.B., Vermeulen, R., Byrnes, G., Scalbert, A., Agudo, A., Rinaldi, S., IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Zamora-Ros, R., Cayssials, V., Franceschi, S., Kyrø, C., Weiderpass, E., Hennings, J., Sandström, M., Tjønneland, A., Olsen, A., Overvad, K., Boutron-Ruault, M.-C., Truong, T., Mancini, F.R., Katzke, V., Kühn, T., Boeing, H., Trichopoulou, A., Karakatsani, A., Martimianaki, G., Palli, D., Krogh, V., Panico, S., Tumino, R., Sacerdote, C., Lasheras, C., Rodríguez-Barranco, M., Amiano, P., Colorado-Yohar, S.M., Ardanaz, E., Almquist, M., Ericson, U., Bueno-de-Mesquita, H.B., Vermeulen, R., Byrnes, G., Scalbert, A., Agudo, A., and Rinaldi, S.
Published: 2020

34. Consumption of nuts and seeds and pancreatic ductal adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition

Author: IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Obón-Santacana, M., Luján-Barroso, L., Freisling, H., Naudin, S., Boutron-Ruault, M.-C., Mancini, F.R., Rebours, V., Kühn, T., Katzke, V., Boeing, H., Tjønneland, A., Olsen, A., Overvad, K., Lasheras, C., Rodríguez-Barranco, M., Amiano, P., Santiuste, C., Ardanaz, E., Khaw, K.-T., Wareham, N.J., Aune, D., Trichopoulou, A., Thriskos, P., Peppa, E., Masala, G., Grioni, S., Tumino, R., Panico, S., Bueno-de-Mesquita, B., Sciannameo, V., Vermeulen, R., Sonestedt, E., Sund, M., Weiderpass, E., Skeie, G., Riboli, E., Duell, E.J., IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Obón-Santacana, M., Luján-Barroso, L., Freisling, H., Naudin, S., Boutron-Ruault, M.-C., Mancini, F.R., Rebours, V., Kühn, T., Katzke, V., Boeing, H., Tjønneland, A., Olsen, A., Overvad, K., Lasheras, C., Rodríguez-Barranco, M., Amiano, P., Santiuste, C., Ardanaz, E., Khaw, K.-T., Wareham, N.J., Aune, D., Trichopoulou, A., Thriskos, P., Peppa, E., Masala, G., Grioni, S., Tumino, R., Panico, S., Bueno-de-Mesquita, B., Sciannameo, V., Vermeulen, R., Sonestedt, E., Sund, M., Weiderpass, E., Skeie, G., Riboli, E., and Duell, E.J.
Published: 2020

35. Blood pressure and risk of cancer in the European Prospective Investigation into Cancer and Nutrition

Author: IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Christakoudi, S., Kakourou, A., Markozannes, G., Tzoulaki, I., Weiderpass, E., Brennan, P., Gunter, M., Dahm, C.C., Overvad, K., Olsen, A., Tjønneland, A., Boutron-Ruault, M.-C., Madika, A.-L., Severi, G., Katzke, V., Kühn, T., Bergmann, M.M., Boeing, H., Karakatsani, A., Martimianaki, G., Thriskos, P., Masala, G., Sieri, S., Panico, S., Tumino, R., Ricceri, F., Agudo, A., Redondo-Sánchez, D., Colorado-Yohar, S.M., Mokoroa, O., Melander, O., Stocks, T., Häggström, C., Harlid, S., Bueno-de-Mesquita, B., van Gils, C.H., Vermeulen, R.C.H., Khaw, K.-T., Wareham, N.J., Tong, T.Y.N., Freisling, H., Johansson, M., Lennon, H., Aune, D., Riboli, E., Trichopoulos, D., Trichopoulou, A., Tsilidis, K.K., IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Christakoudi, S., Kakourou, A., Markozannes, G., Tzoulaki, I., Weiderpass, E., Brennan, P., Gunter, M., Dahm, C.C., Overvad, K., Olsen, A., Tjønneland, A., Boutron-Ruault, M.-C., Madika, A.-L., Severi, G., Katzke, V., Kühn, T., Bergmann, M.M., Boeing, H., Karakatsani, A., Martimianaki, G., Thriskos, P., Masala, G., Sieri, S., Panico, S., Tumino, R., Ricceri, F., Agudo, A., Redondo-Sánchez, D., Colorado-Yohar, S.M., Mokoroa, O., Melander, O., Stocks, T., Häggström, C., Harlid, S., Bueno-de-Mesquita, B., van Gils, C.H., Vermeulen, R.C.H., Khaw, K.-T., Wareham, N.J., Tong, T.Y.N., Freisling, H., Johansson, M., Lennon, H., Aune, D., Riboli, E., Trichopoulos, D., Trichopoulou, A., and Tsilidis, K.K.
Published: 2020

36. Anthropometric and reproductive factors and risk of esophageal and gastric cancer by subtype and subsite: Results from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Author: IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Sanikini, H., Sophiea, M., Rinaldi, S., Agudo, A., Duell, E.J., Weiderpass, E., Overvad, K., Tjønneland, A., Halkjær, J., Boutron-Ruault, M.-C., Carbonnel, F., Cervenka, I., Boeing, H., Kaaks, R., Kühn, T., Trichopoulou, A., Martimianaki, G., Karakatsani, A., Pala, V., Palli, D., Mattiello, A., Tumino, R., Sacerdote, C., Skeie, G., Rylander, C., Chirlaque López, M.-D., Sánchez, M.-J., Ardanaz, E., Regnér, S., Stocks, T., Bueno-de-Mesquita, B., Vermeulen, R.C.H., Aune, D., Tong, T.Y.N., Kliemann, N., Murphy, N., Chadeau-Hyam, M., Gunter, M.J., Cross, A.J., IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Sanikini, H., Sophiea, M., Rinaldi, S., Agudo, A., Duell, E.J., Weiderpass, E., Overvad, K., Tjønneland, A., Halkjær, J., Boutron-Ruault, M.-C., Carbonnel, F., Cervenka, I., Boeing, H., Kaaks, R., Kühn, T., Trichopoulou, A., Martimianaki, G., Karakatsani, A., Pala, V., Palli, D., Mattiello, A., Tumino, R., Sacerdote, C., Skeie, G., Rylander, C., Chirlaque López, M.-D., Sánchez, M.-J., Ardanaz, E., Regnér, S., Stocks, T., Bueno-de-Mesquita, B., Vermeulen, R.C.H., Aune, D., Tong, T.Y.N., Kliemann, N., Murphy, N., Chadeau-Hyam, M., Gunter, M.J., and Cross, A.J.
Published: 2020

37. Plasma polyphenols associated with lower high-sensitivity C-reactive protein concentrations: A cross-sectional study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Author: IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Harms, L.M., Scalbert, A., Zamora-Ros, R., Rinaldi, S., Jenab, M., Murphy, N., Achaintre, D., Tjønneland, A., Olsen, A., Overvad, K., Romana Mancini, F., Mahamat-Saleh, Y., Boutron-Ruault, M.-C., Kühn, T., Katzke, V., Trichopoulou, A., Martimianaki, G., Karakatsani, A., Palli, D., Panico, S., Sieri, S., Tumino, R., Sacerdote, C., Bueno-De-Mesquita, B., Vermeulen, R.C.H., Weiderpass, E., Nøst, T.H., Lasheras, C., Rodríguez-Barranco, M., Huerta, J.M., Barricarte, A., Dorronsoro, M., Hultdin, J., Gunter, M., Riboli, E., Aleksandrova, K., IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Harms, L.M., Scalbert, A., Zamora-Ros, R., Rinaldi, S., Jenab, M., Murphy, N., Achaintre, D., Tjønneland, A., Olsen, A., Overvad, K., Romana Mancini, F., Mahamat-Saleh, Y., Boutron-Ruault, M.-C., Kühn, T., Katzke, V., Trichopoulou, A., Martimianaki, G., Karakatsani, A., Palli, D., Panico, S., Sieri, S., Tumino, R., Sacerdote, C., Bueno-De-Mesquita, B., Vermeulen, R.C.H., Weiderpass, E., Nøst, T.H., Lasheras, C., Rodríguez-Barranco, M., Huerta, J.M., Barricarte, A., Dorronsoro, M., Hultdin, J., Gunter, M., Riboli, E., and Aleksandrova, K.
Published: 2020

38. Association between Soft Drink Consumption and Mortality in 10 European Countries

Author: Mullee, A., Romaguera, D., Pearson-Stuttard, J., Viallon, V., Stepien, M., Freisling, H., Fagherazzi, G., Mancini, F.R., Boutron-Ruault, M.-C., Kühn, T., Kaaks, R., Boeing, H., Aleksandrova, K., Tjønneland, A., Halkjær, J., Overvad, K., Weiderpass, E., Skeie, G., Parr, C.L., Quirós, J.R., Agudo, A., Sánchez, M.-J., Amiano, P., Cirera, L., Ardanaz, E., Khaw, K.-T., Tong, T.Y.N., Trichopoulou, A., Martimianaki, G., Karakatsani, A., Palli, D., Agnoli, C., Tumino, R., Sacerdote, C., Panico, S., Bueno-De-Mesquita, B., Verschuren, W.M.M., Vermeulen, R., Ramne, S., Sonestedt, E., Van Guelpen, B., Holgersson, P.L., Tsilidis, K.K., Heath, A.K., Riboli, E., Gunter, M.J., Murphy, N., Mullee, A., Romaguera, D., Pearson-Stuttard, J., Viallon, V., Stepien, M., Freisling, H., Fagherazzi, G., Mancini, F.R., Boutron-Ruault, M.-C., Kühn, T., Kaaks, R., Boeing, H., Aleksandrova, K., Tjønneland, A., Halkjær, J., Overvad, K., Weiderpass, E., Skeie, G., Parr, C.L., Quirós, J.R., Agudo, A., Sánchez, M.-J., Amiano, P., Cirera, L., Ardanaz, E., Khaw, K.-T., Tong, T.Y.N., Trichopoulou, A., Martimianaki, G., Karakatsani, A., Palli, D., Agnoli, C., Tumino, R., Sacerdote, C., Panico, S., Bueno-De-Mesquita, B., Verschuren, W.M.M., Vermeulen, R., Ramne, S., Sonestedt, E., Van Guelpen, B., Holgersson, P.L., Tsilidis, K.K., Heath, A.K., Riboli, E., Gunter, M.J., and Murphy, N.
Abstract: Importance Soft drinks are frequently consumed, but whether this consumption is associated with mortality risk is unknown and has been understudied in European populations to date. Objective To examine the association between total, sugar-sweetened, and artificially sweetened soft drink consumption and subsequent total and cause-specific mortality. Design, Setting, and Participants This population-based cohort study involved participants (n = 451 743 of the full cohort) in the European Prospective Investigation into Cancer and Nutrition (EPIC), an ongoing, large multinational cohort of people from 10 European countries (Denmark, France, Germany, Greece, Italy, the Netherlands, Norway, Spain, Sweden, and the United Kingdom), with participants recruited between January 1, 1992, and December 31, 2000. Excluded participants were those who reported cancer, heart disease, stroke, or diabetes at baseline; those with implausible dietary intake data; and those with missing soft drink consumption or follow-up information. Data analyses were performed from February 1, 2018, to October 1, 2018. Exposure Consumption of total, sugar-sweetened, and artificially sweetened soft drinks. Main Outcomes and Measures Total mortality and cause-specific mortality. Hazard ratios (HRs) and 95% CIs were estimated using multivariable Cox proportional hazards regression models adjusted for other mortality risk factors. Results In total, 521 330 individuals were enrolled. Of this total, 451 743 (86.7%) were included in the study, with a mean (SD) age of 50.8 (9.8) years and with 321 081 women (71.1%). During a mean (range) follow-up of 16.4 (11.1 in Greece to 19.2 in France) years, 41 693 deaths occurred. Higher all-cause mortality was found among participants who consumed 2 or more glasses per day (vs consumers of <1 glass per month) of total soft drinks (hazard ratio [HR], 1.17; 95% CI, 1.11-1.22; P < .001), sugar-sweetened soft drinks (HR, 1.
Published: 2019

39. Methodological issues in a prospective study on plasma concentrations of persistent organic pollutants and pancreatic cancer risk within the EPIC cohort

Author: Gasull, M., Pumarega, J., Kiviranta, H., Rantakokko, P., Raaschou-Nielsen, O., Bergdahl, I.A., Sandanger, T.M., Goñi, F., Cirera, L., Donat-Vargas, C., Alguacil, J., Iglesias, M., Tjønneland, A., Overvad, K., Mancini, F.R., Boutron-Ruault, M.-C., Severi, G., Johnson, T., Kühn, T., Trichopoulou, A., Karakatsani, A., Peppa, E., Palli, D., Pala, V., Tumino, R., Naccarati, A., Panico, S., Verschuren, M., Vermeulen, R., Rylander, C., Nøst, T.H., Rodríguez-Barranco, M., Molinuevo, A., Chirlaque, M.-D., Ardanaz, E., Sund, M., Key, T., Ye, W., Jenab, M., Michaud, D., Matullo, G., Canzian, F., Kaaks, R., Nieters, A., Nöthlings, U., Jeurnink, S., Chajes, V., Matejcic, M., Gunter, M., Aune, D., Riboli, E., Agudo, A., Weiderpass, E., Bueno-de-Mesquita, B., Duell, E.J., Vineis, P., Porta, M., Gasull, M., Pumarega, J., Kiviranta, H., Rantakokko, P., Raaschou-Nielsen, O., Bergdahl, I.A., Sandanger, T.M., Goñi, F., Cirera, L., Donat-Vargas, C., Alguacil, J., Iglesias, M., Tjønneland, A., Overvad, K., Mancini, F.R., Boutron-Ruault, M.-C., Severi, G., Johnson, T., Kühn, T., Trichopoulou, A., Karakatsani, A., Peppa, E., Palli, D., Pala, V., Tumino, R., Naccarati, A., Panico, S., Verschuren, M., Vermeulen, R., Rylander, C., Nøst, T.H., Rodríguez-Barranco, M., Molinuevo, A., Chirlaque, M.-D., Ardanaz, E., Sund, M., Key, T., Ye, W., Jenab, M., Michaud, D., Matullo, G., Canzian, F., Kaaks, R., Nieters, A., Nöthlings, U., Jeurnink, S., Chajes, V., Matejcic, M., Gunter, M., Aune, D., Riboli, E., Agudo, A., Weiderpass, E., Bueno-de-Mesquita, B., Duell, E.J., Vineis, P., and Porta, M.
Abstract: Background The use of biomarkers of environmental exposure to explore new risk factors for pancreatic cancer presents clinical, logistic, and methodological challenges that are also relevant in research on other complex diseases. Objectives First, to summarize the main design features of a prospective case-control study –nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort– on plasma concentrations of persistent organic pollutants (POPs) and pancreatic cancer risk. And second, to assess the main methodological challenges posed by associations among characteristics and habits of study participants, fasting status, time from blood draw to cancer diagnosis, disease progression bias, basis of cancer diagnosis, and plasma concentrations of lipids and POPs. Results from etiologic analyses on POPs and pancreatic cancer risk, and other analyses, will be reported in future articles. Methods Study subjects were 1533 participants (513 cases and 1020 controls matched by study centre, sex, age at blood collection, date and time of blood collection, and fasting status) enrolled between 1992 and 2000. Plasma concentrations of 22 POPs were measured by gas chromatography - triple quadrupole mass spectrometry (GC-MS/MS). To estimate the magnitude of the associations we calculated multivariate-adjusted odds ratios by unconditional logistic regression, and adjusted geometric means by General Linear Regression Models. Results There were differences among countries in subjects’ characteristics (as age, gender, smoking, lipid and POP concentrations), and in study characteristics (as time from blood collection to index date, year of last follow-up, length of follow-up, basis of cancer diagnosis, and fasting status). Adjusting for centre and time of blood collection, no factors were significantly associated with fasting status. Plasma concentrations of lipids were related to age, body mass index, fasting, cou
Published: 2019

40. General and abdominal adiposity and the risk of Parkinson's disease: A prospective cohort study

Author: Riso, L., Kaaks, R., Kühn, T., Sookthai, D., Forsgren, L., Trupp, M., Trichopoulou, A., La Vecchia, C., Karakatsani, A., Gavrila, D., Ferrari, P., Freisling, H., Petersson, J., Lewan, S., Vermeulen, R.C., Panico, S., Masala, G., Ardanaz, E., Krogh, V., Perneczky, R., Middleton, L.T., Mokoroa, O., Sacerdote, C., Sieri, S., Hayat, S.A., Brayne, C., Riboli, E., Vineis, P., Gallo, V., Katzke, V.A., Riso, L., Kaaks, R., Kühn, T., Sookthai, D., Forsgren, L., Trupp, M., Trichopoulou, A., La Vecchia, C., Karakatsani, A., Gavrila, D., Ferrari, P., Freisling, H., Petersson, J., Lewan, S., Vermeulen, R.C., Panico, S., Masala, G., Ardanaz, E., Krogh, V., Perneczky, R., Middleton, L.T., Mokoroa, O., Sacerdote, C., Sieri, S., Hayat, S.A., Brayne, C., Riboli, E., Vineis, P., Gallo, V., and Katzke, V.A.
Published: 2019

41. Comparison of metabolite networks from four German population-based studies

Author: Iqbal, K., Dietrich, S., Wittenbecher, C., Krumsiek, J., Kühn, T., Lacruz, M.E., Kluttig, A., Prehn, C., Adamski, J., von Bergen, Martin, Kaaks, R., Schulze, M.B., Boeing, H., Floegel, A., Iqbal, K., Dietrich, S., Wittenbecher, C., Krumsiek, J., Kühn, T., Lacruz, M.E., Kluttig, A., Prehn, C., Adamski, J., von Bergen, Martin, Kaaks, R., Schulze, M.B., Boeing, H., and Floegel, A.
Abstract: BackgroundMetabolite networks are suggested to reflect biological pathways in health and disease. However, it is unknown whether such metabolite networks are reproducible across different populations. Therefore, the current study aimed to investigate similarity of metabolite networks in four German population-based studies.MethodsOne hundred serum metabolites were quantified in European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam (n = 2458), EPIC-Heidelberg (n = 812), KORA (Cooperative Health Research in the Augsburg Region) (n = 3029) and CARLA (Cardiovascular Disease, Living and Ageing in Halle) (n = 1427) with targeted metabolomics. In a cross-sectional analysis, Gaussian graphical models were used to construct similar networks of 100 edges each, based on partial correlations of these metabolites. The four metabolite networks of the top 100 edges were compared based on (i) common features, i.e. number of common edges, Pearson correlation (r) and hamming distance (h); and (ii) meta-analysis of the four networks.ResultsAmong the four networks, 57 common edges and 66 common nodes (metabolites) were identified. Pairwise network comparisons showed moderate to high similarity (r = 63–0.96, h = 7–72), among the networks. Meta-analysis of the networks showed that, among the 100 edges and 89 nodes of the meta-analytic network, 57 edges and 66 metabolites were present in all the four networks, 58–76 edges and 75–89 nodes were present in at least three networks, and 63–84 edges and 76–87 edges were present in at least two networks. The meta-analytic network showed clear grouping of 10 sphingolipids, 8 lyso-phosphatidylcholines, 31 acyl-alkyl-phosphatidylcholines, 30 diacyl-phosphatidylcholines, 8 amino acids and 2 acylcarnitines.ConclusionsWe found structural similarity in metabolite networks from four large studies. Using a meta-analytic network, as a new approach for combining metabolite data from different studies, closely related metabolites could
Published: 2018

42. The chemistry-climate model ECHAM6.3-HAM2.3-MOZ1.0

Author: Schultz, M.G., Stadtler, S., Schroder, Sören, Taraborrelli, D., Franco, Bruno, Krefting, J., Henrot, A., Ferrachat, S., Lohmann, U., Neubauer, D., Wahl, S., Siegenthaler-Le Drian, C., Kokkola, H., Kühn, T., Rast, S., Schmidt, H., Stier, P., Kinnison, D., Tyndall, G.S., Orlando, J.J., Wespes, Catherine, Schultz, M.G., Stadtler, S., Schroder, Sören, Taraborrelli, D., Franco, Bruno, Krefting, J., Henrot, A., Ferrachat, S., Lohmann, U., Neubauer, D., Wahl, S., Siegenthaler-Le Drian, C., Kokkola, H., Kühn, T., Rast, S., Schmidt, H., Stier, P., Kinnison, D., Tyndall, G.S., Orlando, J.J., and Wespes, Catherine
Abstract: The chemistry-climate model ECHAM-HAMMOZ contains a detailed representation of tropospheric and stratospheric reactive chemistry and state-of-the-art parameterizations of aerosols using either a modal scheme (M7) or a bin scheme (SALSA). This article describes and evaluates the model version ECHAM6.3-HAM2.3-MOZ1.0 with a focus on the tropospheric gas-phase chemistry. A 10-year model simulation was performed to test the stability of the model and provide data for its evaluation. The comparison to observations concentrates on the year 2008 and includes total column observations of ozone and CO from IASI and OMI, Aura MLS observations of temperature, HNO3, ClO, and O3 for the evaluation of polar stratospheric processes, an ozonesonde climatology, surface ozone observations from the TOAR database, and surface CO data from the Global Atmosphere Watch network. Global budgets of ozone, OH, NOx, aerosols, clouds, and radiation are analyzed and compared to the literature. ECHAM-HAMMOZ performs well in many aspects. However, in the base simulation, lightning NOx emissions are very low, and the impact of the heterogeneous reaction of HNO3 on dust and sea salt aerosol is too strong. Sensitivity simulations with increased lightning NOx or modified heterogeneous chemistry deteriorate the comparison with observations and yield excessively large ozone budget terms and too much OH. We hypothesize that this is an impact of potential issues with tropical convection in the ECHAM model., SCOPUS: ar.j, info:eu-repo/semantics/published
Published: 2018

43. P722 Prediagnostic serum vitamin D levels and risk of inflammatory bowel disease : a pan-European, nested case-control study

Author: Opstelten, J, Chan, S, Hart, A, van Schaik, F, Siersema, P, Lentjes, E, Khaw, K-T, Luben, R, Key, T, Boeing, H, Bergmann, M, Overvad, K, Palli, D, Masala, G, Racine, A, Carbonnel, F, Boutron-Ruault, M-C, Tjønneland, A, Olsen, A, Andersen, V, Kaaks, R, Kühn, T, Tumino, R, Trichopoulou, A, Verschuren, M, Witteman, B, Oldenburg, B, Opstelten, J, Chan, S, Hart, A, van Schaik, F, Siersema, P, Lentjes, E, Khaw, K-T, Luben, R, Key, T, Boeing, H, Bergmann, M, Overvad, K, Palli, D, Masala, G, Racine, A, Carbonnel, F, Boutron-Ruault, M-C, Tjønneland, A, Olsen, A, Andersen, V, Kaaks, R, Kühn, T, Tumino, R, Trichopoulou, A, Verschuren, M, Witteman, B, and Oldenburg, B
Published: 2017

44. Alcohol consumption and the risk of renal cancers in the European Prospective Investigation into Cancer and Nutrition (EPIC). Wozniak MB, Brennan P, Brenner DR, Overvad K, Olsen A, Tjønneland A, Boutron-Ruault MC, Clavel-Chapelon F, Fagherazzi G, Katzke V, Kühn T, Boeing H, Bergmann MM, Steffen A, Naska A, Trichopoulou A, Trichopoulos D, Saieva C, Grioni S

Author: Jay, Raman, Brennan, P., Brenner, X., Overvad, K., Olsen, A., Tjønneland, A., Boutron-Ruault, M. C., Clavel-Chapelon, F., Fagherazzi, X., Katzke, V., Kühn, T., Boeing, H., Bergmann, M. M., Steffen, A., Naska, A., Trichopoulou, A., Trichopoulos, D., Saieva, C., Grioni, S., Panico, S., Tumino, R., Vineis, P., Bueno-de-Mesquita, H. B., Hjartåker, A., Peeters, P. H., Weiderpass, E., Arriola, L., Molina-Montes, E., Duell, E. J., Santiuste, C., Alonso de la Torre, R., Barricarte Gurrea, A., Stocks, T., Johansson, M., Ljungberg, B., Wareham, N., Khaw, K. T., Travis, R. C., Cross, A. J., Murphy, N., Riboli, E., Scelo, G., Jay, Raman, Brennan, P., Brenner, X., Overvad, K., Olsen, A., Tjønneland, A., Boutron-Ruault, M. C., Clavel-Chapelon, F., Fagherazzi, X., Katzke, V., Kühn, T., Boeing, H., Bergmann, M. M., Steffen, A., Naska, A., Trichopoulou, A., Trichopoulos, D., Saieva, C., Grioni, S., Panico, S., Tumino, R., Vineis, P., Bueno-de-Mesquita, H. B., Hjartåker, A., Peeters, P. H., Weiderpass, E., Arriola, L., Molina-Montes, E., Duell, E. J., Santiuste, C., Alonso de la Torre, R., Barricarte Gurrea, A., Stocks, T., Johansson, M., Ljungberg, B., Wareham, N., Khaw, K. T., Travis, R. C., Cross, A. J., Murphy, N., Riboli, E., and Scelo, G.
Published: 2017

45. Alcohol consumption and the risk of renal cancers in the European Prospective Investigation into Cancer and Nutrition (EPIC). Wozniak MB, Brennan P, Brenner DR, Overvad K, Olsen A, Tjønneland A, Boutron-Ruault MC, Clavel-Chapelon F, Fagherazzi G, Katzke V, Kühn T, Boeing H, Bergmann MM, Steffen A, Naska A, Trichopoulou A, Trichopoulos D, Saieva C, Grioni S

Author: Jay, Raman, Brennan, P., Brenner, X., Overvad, K., Olsen, A., Tjønneland, A., Boutron-Ruault, M. C., Clavel-Chapelon, F., Fagherazzi, X., Katzke, V., Kühn, T., Boeing, H., Bergmann, M. M., Steffen, A., Naska, A., Trichopoulou, A., Trichopoulos, D., Saieva, C., Grioni, S., Panico, S., Tumino, R., Vineis, P., Bueno-de-Mesquita, H. B., Hjartåker, A., Peeters, P. H., Weiderpass, E., Arriola, L., Molina-Montes, E., Duell, E. J., Santiuste, C., Alonso de la Torre, R., Barricarte Gurrea, A., Stocks, T., Johansson, M., Ljungberg, B., Wareham, N., Khaw, K. T., Travis, R. C., Cross, A. J., Murphy, N., Riboli, E., Scelo, G., Jay, Raman, Brennan, P., Brenner, X., Overvad, K., Olsen, A., Tjønneland, A., Boutron-Ruault, M. C., Clavel-Chapelon, F., Fagherazzi, X., Katzke, V., Kühn, T., Boeing, H., Bergmann, M. M., Steffen, A., Naska, A., Trichopoulou, A., Trichopoulos, D., Saieva, C., Grioni, S., Panico, S., Tumino, R., Vineis, P., Bueno-de-Mesquita, H. B., Hjartåker, A., Peeters, P. H., Weiderpass, E., Arriola, L., Molina-Montes, E., Duell, E. J., Santiuste, C., Alonso de la Torre, R., Barricarte Gurrea, A., Stocks, T., Johansson, M., Ljungberg, B., Wareham, N., Khaw, K. T., Travis, R. C., Cross, A. J., Murphy, N., Riboli, E., and Scelo, G.
Published: 2017

46. P722 Prediagnostic serum vitamin D levels and risk of inflammatory bowel disease : a pan-European, nested case-control study

Author: Opstelten, J, Chan, S, Hart, A, van Schaik, F, Siersema, P, Lentjes, E, Khaw, K-T, Luben, R, Key, T, Boeing, H, Bergmann, M, Overvad, K, Palli, D, Masala, G, Racine, A, Carbonnel, F, Boutron-Ruault, M-C, Tjønneland, A, Olsen, A, Andersen, V, Kaaks, R, Kühn, T, Tumino, R, Trichopoulou, A, Verschuren, M, Witteman, B, Oldenburg, B, Opstelten, J, Chan, S, Hart, A, van Schaik, F, Siersema, P, Lentjes, E, Khaw, K-T, Luben, R, Key, T, Boeing, H, Bergmann, M, Overvad, K, Palli, D, Masala, G, Racine, A, Carbonnel, F, Boutron-Ruault, M-C, Tjønneland, A, Olsen, A, Andersen, V, Kaaks, R, Kühn, T, Tumino, R, Trichopoulou, A, Verschuren, M, Witteman, B, and Oldenburg, B
Published: 2017

47. Alcohol consumption and the risk of renal cancers in the European Prospective Investigation into Cancer and Nutrition (EPIC). Wozniak MB, Brennan P, Brenner DR, Overvad K, Olsen A, Tjønneland A, Boutron-Ruault MC, Clavel-Chapelon F, Fagherazzi G, Katzke V, Kühn T, Boeing H, Bergmann MM, Steffen A, Naska A, Trichopoulou A, Trichopoulos D, Saieva C, Grioni S

Author: Jay, Raman, Brennan, P., Brenner, X., Overvad, K., Olsen, A., Tjønneland, A., Boutron-Ruault, M. C., Clavel-Chapelon, F., Fagherazzi, X., Katzke, V., Kühn, T., Boeing, H., Bergmann, M. M., Steffen, A., Naska, A., Trichopoulou, A., Trichopoulos, D., Saieva, C., Grioni, S., Panico, S., Tumino, R., Vineis, P., Bueno-de-Mesquita, H. B., Hjartåker, A., Peeters, P. H., Weiderpass, E., Arriola, L., Molina-Montes, E., Duell, E. J., Santiuste, C., Alonso de la Torre, R., Barricarte Gurrea, A., Stocks, T., Johansson, M., Ljungberg, B., Wareham, N., Khaw, K. T., Travis, R. C., Cross, A. J., Murphy, N., Riboli, E., Scelo, G., Jay, Raman, Brennan, P., Brenner, X., Overvad, K., Olsen, A., Tjønneland, A., Boutron-Ruault, M. C., Clavel-Chapelon, F., Fagherazzi, X., Katzke, V., Kühn, T., Boeing, H., Bergmann, M. M., Steffen, A., Naska, A., Trichopoulou, A., Trichopoulos, D., Saieva, C., Grioni, S., Panico, S., Tumino, R., Vineis, P., Bueno-de-Mesquita, H. B., Hjartåker, A., Peeters, P. H., Weiderpass, E., Arriola, L., Molina-Montes, E., Duell, E. J., Santiuste, C., Alonso de la Torre, R., Barricarte Gurrea, A., Stocks, T., Johansson, M., Ljungberg, B., Wareham, N., Khaw, K. T., Travis, R. C., Cross, A. J., Murphy, N., Riboli, E., and Scelo, G.
Published: 2017

48. P722 Prediagnostic serum vitamin D levels and risk of inflammatory bowel disease : a pan-European, nested case-control study

Author: Opstelten, J, Chan, S, Hart, A, van Schaik, F, Siersema, P, Lentjes, E, Khaw, K-T, Luben, R, Key, T, Boeing, H, Bergmann, M, Overvad, K, Palli, D, Masala, G, Racine, A, Carbonnel, F, Boutron-Ruault, M-C, Tjønneland, A, Olsen, A, Andersen, V, Kaaks, R, Kühn, T, Tumino, R, Trichopoulou, A, Verschuren, M, Witteman, B, Oldenburg, B, Opstelten, J, Chan, S, Hart, A, van Schaik, F, Siersema, P, Lentjes, E, Khaw, K-T, Luben, R, Key, T, Boeing, H, Bergmann, M, Overvad, K, Palli, D, Masala, G, Racine, A, Carbonnel, F, Boutron-Ruault, M-C, Tjønneland, A, Olsen, A, Andersen, V, Kaaks, R, Kühn, T, Tumino, R, Trichopoulou, A, Verschuren, M, Witteman, B, and Oldenburg, B
Published: 2017

49. Serum metabolites and risk of myocardial infarction and ischemic stroke: a targeted metabolomic approach in two German prospective cohorts

Author: Floegel, A., Kühn, T., Sookthai, D., Johnson, T., Prehn, C., Rolle-Kampczyk, Ulrike, Otto, Wolfgang, Weikert, C., Illig, T., von Bergen, Martin, Adamski, J., Boeing, H., Kaaks, R., Pischon, T., Floegel, A., Kühn, T., Sookthai, D., Johnson, T., Prehn, C., Rolle-Kampczyk, Ulrike, Otto, Wolfgang, Weikert, C., Illig, T., von Bergen, Martin, Adamski, J., Boeing, H., Kaaks, R., and Pischon, T.
Abstract: Metabolomic approaches in prospective cohorts may offer a unique snapshot into early metabolic perturbations that are associated with a higher risk of cardiovascular diseases (CVD) in healthy people. We investigated the association of 105 serum metabolites, including acylcarnitines, amino acids, phospholipids and hexose, with risk of myocardial infarction (MI) and ischemic stroke in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam (27,548 adults) and Heidelberg (25,540 adults) cohorts. Using case-cohort designs, we measured metabolites among individuals who were free of CVD and diabetes at blood draw but developed MI (n = 204 and n = 228) or stroke (n = 147 and n = 121) during follow-up (mean, 7.8 and 7.3 years) and among randomly drawn subcohorts (n = 2214 and n = 770). We used Cox regression analysis and combined results using meta-analysis. Independent of classical CVD risk factors, ten metabolites were associated with risk of MI in both cohorts, including sphingomyelins, diacyl-phosphatidylcholines and acyl-alkyl-phosphatidylcholines with pooled relative risks in the range of 1.21–1.40 per one standard deviation increase in metabolite concentrations. The metabolites showed positive correlations with total- and LDL-cholesterol (r ranged from 0.13 to 0.57). When additionally adjusting for total-, LDL- and HDL-cholesterol, triglycerides and C-reactive protein, acyl-alkyl-phosphatidylcholine C36:3 and diacyl-phosphatidylcholines C38:3 and C40:4 remained associated with risk of MI. When added to classical CVD risk models these metabolites further improved CVD prediction (c-statistics increased from 0.8365 to 0.8384 in EPIC-Potsdam and from 0.8344 to 0.8378 in EPIC-Heidelberg). None of the metabolites was consistently associated with stroke risk. Alterations in sphingomyelin and phosphatidylcholine metabolism, and particul
Published: 2017

50. Alcohol consumption and the risk of renal cancers in the European Prospective Investigation into Cancer and Nutrition (EPIC). Wozniak MB, Brennan P, Brenner DR, Overvad K, Olsen A, Tjønneland A, Boutron-Ruault MC, Clavel-Chapelon F, Fagherazzi G, Katzke V, Kühn T, Boeing H, Bergmann MM, Steffen A, Naska A, Trichopoulou A, Trichopoulos D, Saieva C, Grioni S, Panico S, Tumino R, Vineis P, Bueno-de-Mesquita HB, Peeters PH, Hjartåker A, Weiderpass E, Arriola L, Molina-Montes E, Duell EJ, Santiuste C, Alonso de la Torre R, Barricarte Gurrea A, Stocks T, Johansson M, Ljungberg B, Wareham N, Khaw KT, Travis RC, Cross AJ, Murphy N, Riboli E, Scelo G.Int J Cancer. 2015 Oct 15;137(8):1953-66. [Epub 2015 Apr 28]. doi

Author: MS MDL 1, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, Jay, Raman, Brennan, P., Brenner, X., Overvad, K., Olsen, A., Tjønneland, A., Boutron-Ruault, M. C., Clavel-Chapelon, F., Fagherazzi, X., Katzke, V., Kühn, T., Boeing, H., Bergmann, M. M., Steffen, A., Naska, A., Trichopoulou, A., Trichopoulos, D., Saieva, C., Grioni, S., Panico, S., Tumino, R., Vineis, P., Bueno-de-Mesquita, H. B., Hjartåker, A., Peeters, P. H., Weiderpass, E., Arriola, L., Molina-Montes, E., Duell, E. J., Santiuste, C., Alonso de la Torre, R., Barricarte Gurrea, A., Stocks, T., Johansson, M., Ljungberg, B., Wareham, N., Khaw, K. T., Travis, R. C., Cross, A. J., Murphy, N., Riboli, E., Scelo, G., MS MDL 1, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, Jay, Raman, Brennan, P., Brenner, X., Overvad, K., Olsen, A., Tjønneland, A., Boutron-Ruault, M. C., Clavel-Chapelon, F., Fagherazzi, X., Katzke, V., Kühn, T., Boeing, H., Bergmann, M. M., Steffen, A., Naska, A., Trichopoulou, A., Trichopoulos, D., Saieva, C., Grioni, S., Panico, S., Tumino, R., Vineis, P., Bueno-de-Mesquita, H. B., Hjartåker, A., Peeters, P. H., Weiderpass, E., Arriola, L., Molina-Montes, E., Duell, E. J., Santiuste, C., Alonso de la Torre, R., Barricarte Gurrea, A., Stocks, T., Johansson, M., Ljungberg, B., Wareham, N., Khaw, K. T., Travis, R. C., Cross, A. J., Murphy, N., Riboli, E., and Scelo, G.
Published: 2017

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