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8. Stress Research:Past, Present, and Future

Author

Pfaff, Donald W., Volkow, Nora D., Rubinstein, John L., de Kloet, E. Ronald, Joëls, Marian, Pfaff, Donald W., Volkow, Nora D., Rubinstein, John L., de Kloet, E. Ronald, and Joëls, Marian

Abstract

This chapter starts with highlighting the evolution of the stress concept and the discovery of mediators that coordinate stress adaptation. Next, progress in the unraveling of the mechanism underlying the action of these stress mediators is discussed, focusing on glucocorticoids as the end product of the hypothalamus-pituitary-adrenal (HPA) axis. This action exerted by the glucocorticoids is mediated by a dual receptor system: mineralocorticoid (MR) and glucocorticoid receptors (GR). With these receptors as leading theme we present five highlights that illustrate the serendipitous nature of stress research. These five highlights are integrated in the final section which culminates in reflections on the role of stress in mental health. In these reflections we merge the mind-boggling complexity of molecular signaling pathways with neuroendocrine communication, integrating body and brain functions. The new insights will be used during the next decennium to target, in an individual-specific fashion, the stress system with the objective to enhance the quality of life.

Published
2022

9. The mouse brain after foot shock in four dimensions: Temporal dynamics at a single-cell resolution

Author

TN groep Joëls, TN groep Pasterkamp, Brain, Translational Neuroscience, Regenerative Medicine and Stem Cells, Bonapersona, Valeria, Schuler, Heike, Damsteegt, Ruth, Adolfs, Youri, Pasterkamp, R. Jeroen, van den Heuvel, Martijn P., Joëls, Marian, Sarabdjitsingh, R. Angela, TN groep Joëls, TN groep Pasterkamp, Brain, Translational Neuroscience, Regenerative Medicine and Stem Cells, Bonapersona, Valeria, Schuler, Heike, Damsteegt, Ruth, Adolfs, Youri, Pasterkamp, R. Jeroen, van den Heuvel, Martijn P., Joëls, Marian, and Sarabdjitsingh, R. Angela

Published
2022

12. Disrupted upregulation of salience network connectivity during acute stress in siblings of schizophrenia patients

Author

Sub General Pharmacology, Leerstoel Kemner, Social and personality development: A transactional approach, Afd Psychologische functieleer, Helmholtz Institute, Experimental Psychology (onderzoeksprogramma PF), van Leeuwen, Judith M C, Vinkers, Christiaan H, Vink, Matthijs, Kahn, René S, Joëls, Marian, Hermans, Erno J, Sub General Pharmacology, Leerstoel Kemner, Social and personality development: A transactional approach, Afd Psychologische functieleer, Helmholtz Institute, Experimental Psychology (onderzoeksprogramma PF), van Leeuwen, Judith M C, Vinkers, Christiaan H, Vink, Matthijs, Kahn, René S, Joëls, Marian, and Hermans, Erno J

Published
2021

13. Disrupted upregulation of salience network connectivity during acute stress in siblings of schizophrenia patients

Author

Sub General Pharmacology, Leerstoel Kemner, Social and personality development: A transactional approach, Afd Psychologische functieleer, Helmholtz Institute, Experimental Psychology (onderzoeksprogramma PF), van Leeuwen, Judith M C, Vinkers, Christiaan H, Vink, Matthijs, Kahn, René S, Joëls, Marian, Hermans, Erno J, Sub General Pharmacology, Leerstoel Kemner, Social and personality development: A transactional approach, Afd Psychologische functieleer, Helmholtz Institute, Experimental Psychology (onderzoeksprogramma PF), van Leeuwen, Judith M C, Vinkers, Christiaan H, Vink, Matthijs, Kahn, René S, Joëls, Marian, and Hermans, Erno J

Published
2021

14. The Role of Stress in Bipolar Disorder

Author

Umeoka, Eduardo H L, van Leeuwen, Judith M C, Vinkers, Christiaan H, Joëls, Marian, Umeoka, Eduardo H L, van Leeuwen, Judith M C, Vinkers, Christiaan H, and Joëls, Marian

Abstract

Stress is a major risk factor for bipolar disorder. Even though we do not completely understand how stress increases the risk for the onset and poorer course of bipolar disorder, knowledge of stress physiology is rapidly evolving. Following stress, stress hormones - including (nor)adrenaline and corticosteroid - reach the brain and change neuronal function in a time-, region-, and receptor-dependent manner. Stress has direct consequences for a range of cognitive functions which are time-dependent. Directly after stress, emotional processing is increased at the cost of higher brain functions. In the aftermath of stress, the reverse is seen, i.e., increased executive function and contextualization of information. In bipolar disorder, basal corticosteroid levels (under non-stressed conditions) are generally found to be increased with blunted responses in response to experimental stress. Moreover, patients who have bipolar disorder generally show impaired brain function, including reward processing. There is some evidence for a causal role of (dysfunction of) the stress system in the etiology of bipolar disorder and their effects on brain system functionality. However, longitudinal studies investigating the functionality of the stress systems in conjunction with detailed information on the development and course of bipolar disorder are vital to understand in detail how stress increases the risk for bipolar disorder.

Published
2021

16. Disrupted upregulation of salience network connectivity during acute stress in siblings of schizophrenia patients

Author

Brain, Risico & Preventie Ond., Onderzoek Bob Oranje, Diagnostiek & Vroege Psychose Medisch, MS Neonatologie, Onderzoeksgroep 11, TN groep Joëls, van Leeuwen, Judith M C, Vinkers, Christiaan H, Vink, Matthijs, Kahn, René S, Joëls, Marian, Hermans, Erno J, Brain, Risico & Preventie Ond., Onderzoek Bob Oranje, Diagnostiek & Vroege Psychose Medisch, MS Neonatologie, Onderzoeksgroep 11, TN groep Joëls, van Leeuwen, Judith M C, Vinkers, Christiaan H, Vink, Matthijs, Kahn, René S, Joëls, Marian, and Hermans, Erno J

Published
2021

21. Reward-Related Striatal Responses Following Stress in Healthy Individuals and Patients With Bipolar Disorder

Author

Leerstoel Kemner, Social and personality development: A transactional approach, Experimental Psychology (onderzoeksprogramma PF), Afd Psychologische functieleer, Helmholtz Institute, Sub General Pharmacology, van Leeuwen, Judith M C, Vink, Matthijs, Joëls, Marian, Kahn, René S, Hermans, Erno J, Vinkers, Christiaan H, Leerstoel Kemner, Social and personality development: A transactional approach, Experimental Psychology (onderzoeksprogramma PF), Afd Psychologische functieleer, Helmholtz Institute, Sub General Pharmacology, van Leeuwen, Judith M C, Vink, Matthijs, Joëls, Marian, Kahn, René S, Hermans, Erno J, and Vinkers, Christiaan H

Published
2019

25. The effects of different rearing conditions on sexual maturation and maternal care in heterozygous mineralocorticoid receptor knockout mice

Author

Knop, Jelle, van IJzendoorn, Marinus H., Bakermans-Kranenburg, Marian J., Joëls, Marian, van der Veen, Rixt, Knop, Jelle, van IJzendoorn, Marinus H., Bakermans-Kranenburg, Marian J., Joëls, Marian, and van der Veen, Rixt

Abstract

Sexual and social development is affected by a complex interplay between genetic makeup and the early-life rearing environment. While many rodent studies focused primarily on the detrimental effects of early-life stress, human literature suggests that genetic susceptibility may not be restricted to negative environments; it may also enhance the beneficial effects of positive rearing conditions. To examine this interaction in a controlled setting, heterozygous mineralocorticoid receptor knockout (MR +/− ) mice and control litter mates were exposed to a limited nesting/bedding (LN, impoverished), standard nesting (SN, control) or communal nesting (CN, enriched) paradigm from postnatal day 2–9 (P2-P9). Offspring was monitored for puberty onset between P24-P36 and, in females, maternal care-giving (i.e. as F1) during adulthood, after which basal corticosterone was measured. Different home-cage environments resulted in profound differences in received maternal care and offspring body weight. In male offspring, LN resulted in delayed puberty onset that was mediated by body weight and unpredictability of maternal care received during early development. In female offspring, rearing condition did not significantly alter sexual maturation and had little effect on their own maternal care-giving behavior. Genotype did affect maternal care: female MR +/− offspring exhibited a less active nursing style and upregulated fragmentation during adulthood, irrespective of early life conditions. Basal corticosterone levels were highest in MR +/− mice with a background of LN. Overall, we found a gene-by-environment interaction with respect to basal corticosterone levels, but not for sexual maturation or maternal behavior.

Published
2019
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26. Hyperthermia-induced seizures followed by repetitive stress are associated with age-dependent changes in specific aspects of the mouse stress system

Author

Umeoka, Eduardo H.L., Robinson, Edward J., Turimella, Sada Lakshmi, van Campen, Jolien S., Motta-Teixeira, Lívia C., Sarabdjitsingh, R. Angela, Garcia-Cairasco, Norberto, Braun, Kees, de Graan, Pierre N., Joëls, Marian, Umeoka, Eduardo H.L., Robinson, Edward J., Turimella, Sada Lakshmi, van Campen, Jolien S., Motta-Teixeira, Lívia C., Sarabdjitsingh, R. Angela, Garcia-Cairasco, Norberto, Braun, Kees, de Graan, Pierre N., and Joëls, Marian

Published
2019

28. Hyperthermia-induced seizures followed by repetitive stress are associated with age-dependent changes in specific aspects of the mouse stress system

Author

Umeoka, Eduardo H.L., Robinson, Edward J., Turimella, Sada Lakshmi, van Campen, Jolien S., Motta-Teixeira, Lívia C., Sarabdjitsingh, R. Angela, Garcia-Cairasco, Norberto, Braun, Kees, de Graan, Pierre N., Joëls, Marian, Umeoka, Eduardo H.L., Robinson, Edward J., Turimella, Sada Lakshmi, van Campen, Jolien S., Motta-Teixeira, Lívia C., Sarabdjitsingh, R. Angela, Garcia-Cairasco, Norberto, Braun, Kees, de Graan, Pierre N., and Joëls, Marian

Published
2019

33. Reward-Related Striatal Responses Following Stress in Healthy Individuals and Patients With Bipolar Disorder

Author

Leerstoel Kemner, Social and personality development: A transactional approach, Experimental Psychology (onderzoeksprogramma PF), Afd Psychologische functieleer, Helmholtz Institute, Sub General Pharmacology, van Leeuwen, Judith M C, Vink, Matthijs, Joëls, Marian, Kahn, René S, Hermans, Erno J, Vinkers, Christiaan H, Leerstoel Kemner, Social and personality development: A transactional approach, Experimental Psychology (onderzoeksprogramma PF), Afd Psychologische functieleer, Helmholtz Institute, Sub General Pharmacology, van Leeuwen, Judith M C, Vink, Matthijs, Joëls, Marian, Kahn, René S, Hermans, Erno J, and Vinkers, Christiaan H

Published
2019

36. Hyperthermia-induced seizures followed by repetitive stress are associated with age-dependent changes in specific aspects of the mouse stress system

Author

UMC Utrecht, ZL Kinder Ner en Nec Medisch, TN groep Joëls, Brain, Umeoka, Eduardo H.L., Robinson, Edward J., Turimella, Sada Lakshmi, van Campen, Jolien S., Motta-Teixeira, Lívia C., Sarabdjitsingh, R. Angela, Garcia-Cairasco, Norberto, Braun, Kees, de Graan, Pierre N., Joëls, Marian, UMC Utrecht, ZL Kinder Ner en Nec Medisch, TN groep Joëls, Brain, Umeoka, Eduardo H.L., Robinson, Edward J., Turimella, Sada Lakshmi, van Campen, Jolien S., Motta-Teixeira, Lívia C., Sarabdjitsingh, R. Angela, Garcia-Cairasco, Norberto, Braun, Kees, de Graan, Pierre N., and Joëls, Marian

Published
2019

39. Reward-Related Striatal Responses Following Stress in Healthy Individuals and Patients With Bipolar Disorder

Author

Leerstoel Kemner, Social and personality development: A transactional approach, Experimental Psychology (onderzoeksprogramma PF), Afd Psychologische functieleer, Helmholtz Institute, Sub General Pharmacology, van Leeuwen, Judith M C, Vink, Matthijs, Joëls, Marian, Kahn, René S, Hermans, Erno J, Vinkers, Christiaan H, Leerstoel Kemner, Social and personality development: A transactional approach, Experimental Psychology (onderzoeksprogramma PF), Afd Psychologische functieleer, Helmholtz Institute, Sub General Pharmacology, van Leeuwen, Judith M C, Vink, Matthijs, Joëls, Marian, Kahn, René S, Hermans, Erno J, and Vinkers, Christiaan H

Published
2019

40. The effects of different rearing conditions on sexual maturation and maternal care in heterozygous mineralocorticoid receptor knockout mice

Author

Knop, Jelle, van IJzendoorn, Marinus H., Bakermans-Kranenburg, Marian J., Joëls, Marian, van der Veen, Rixt, Knop, Jelle, van IJzendoorn, Marinus H., Bakermans-Kranenburg, Marian J., Joëls, Marian, and van der Veen, Rixt

Abstract

Sexual and social development is affected by a complex interplay between genetic makeup and the early-life rearing environment. While many rodent studies focused primarily on the detrimental effects of early-life stress, human literature suggests that genetic susceptibility may not be restricted to negative environments; it may also enhance the beneficial effects of positive rearing conditions. To examine this interaction in a controlled setting, heterozygous mineralocorticoid receptor knockout (MR +/− ) mice and control litter mates were exposed to a limited nesting/bedding (LN, impoverished), standard nesting (SN, control) or communal nesting (CN, enriched) paradigm from postnatal day 2–9 (P2-P9). Offspring was monitored for puberty onset between P24-P36 and, in females, maternal care-giving (i.e. as F1) during adulthood, after which basal corticosterone was measured. Different home-cage environments resulted in profound differences in received maternal care and offspring body weight. In male offspring, LN resulted in delayed puberty onset that was mediated by body weight and unpredictability of maternal care received during early development. In female offspring, rearing condition did not significantly alter sexual maturation and had little effect on their own maternal care-giving behavior. Genotype did affect maternal care: female MR +/− offspring exhibited a less active nursing style and upregulated fragmentation during adulthood, irrespective of early life conditions. Basal corticosterone levels were highest in MR +/− mice with a background of LN. Overall, we found a gene-by-environment interaction with respect to basal corticosterone levels, but not for sexual maturation or maternal behavior.

Published
2019
Full Text
View/download PDF

42. Diffusion MRI-based cortical connectome reconstruction : dependency on tractography procedures and neuroanatomical characteristics

Author

Sinke, Michel R.T., Otte, Willem M., Christiaens, Daan, Schmitt, Oliver, Leemans, Alexander, van der Toorn, Annette, Sarabdjitsingh, R. Angela, Joëls, Marian, Dijkhuizen, Rick M., Sinke, Michel R.T., Otte, Willem M., Christiaens, Daan, Schmitt, Oliver, Leemans, Alexander, van der Toorn, Annette, Sarabdjitsingh, R. Angela, Joëls, Marian, and Dijkhuizen, Rick M.

Published
2018

45. Stress and corticosteroids aggravate morphological changes in the dentate gyrus after early-life experimental febrile seizures in mice

Author

van Campen, Jolien S., Hessel, Ellen V.S., Bohmbach, Kirsten, Rizzi, Giorgio, Lucassen, Paul J., Turimella, Sada Lakshmi, Umeoka, Eduardo H.L., Meerhoff, Gideon F., Braun, Kees P.J., de Graan, Pierre N.E., Joëls, Marian, van Campen, Jolien S., Hessel, Ellen V.S., Bohmbach, Kirsten, Rizzi, Giorgio, Lucassen, Paul J., Turimella, Sada Lakshmi, Umeoka, Eduardo H.L., Meerhoff, Gideon F., Braun, Kees P.J., de Graan, Pierre N.E., and Joëls, Marian

Published
2018

49. Diffusion MRI-based cortical connectome reconstruction : dependency on tractography procedures and neuroanatomical characteristics

Author

Sinke, Michel R.T., Otte, Willem M., Christiaens, Daan, Schmitt, Oliver, Leemans, Alexander, van der Toorn, Annette, Sarabdjitsingh, R. Angela, Joëls, Marian, Dijkhuizen, Rick M., Sinke, Michel R.T., Otte, Willem M., Christiaens, Daan, Schmitt, Oliver, Leemans, Alexander, van der Toorn, Annette, Sarabdjitsingh, R. Angela, Joëls, Marian, and Dijkhuizen, Rick M.

Published
2018

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