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8 results on '"Intussusceptive angiogenesis"'

1. Endothelial MT1-MMP targeting limits intussusceptive angiogenesis and colitis via TSP1/nitric oxide axis

Author

Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Clemente, Cristina [0000-0002-5831-9132], Gonzalo, Pilar [0000-0001-8811-8369], Martínez, Fernando [0000-0003-0908-9366], Linares, Pablo M. [0000-0003-4090-6942], Chaparro, María [0000-0002-9275-4242], Urzainqui, Ana [0000-0001-9326-6112], Andrés, Vicente [0000-0002-0125-7209], Seiki, Motoharu [0000-0002-3909-0782], Gisbert, Javier P. [0000-0003-2090-3445], Arroyo, Alicia G. [0000-0002-1536-3846], Esteban, Sergio, Clemente, Cristina, Koziol, Agnieszka, Gonzalo, Pilar, Rius, Cristina, Martínez, Fernando, Linares, Pablo M., Chaparro, María, Urzainqui, Ana, Andrés, Vicente, Seiki, Motoharu, Gisbert, Javier P., Arroyo, Alicia G., Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Clemente, Cristina [0000-0002-5831-9132], Gonzalo, Pilar [0000-0001-8811-8369], Martínez, Fernando [0000-0003-0908-9366], Linares, Pablo M. [0000-0003-4090-6942], Chaparro, María [0000-0002-9275-4242], Urzainqui, Ana [0000-0001-9326-6112], Andrés, Vicente [0000-0002-0125-7209], Seiki, Motoharu [0000-0002-3909-0782], Gisbert, Javier P. [0000-0003-2090-3445], Arroyo, Alicia G. [0000-0002-1536-3846], Esteban, Sergio, Clemente, Cristina, Koziol, Agnieszka, Gonzalo, Pilar, Rius, Cristina, Martínez, Fernando, Linares, Pablo M., Chaparro, María, Urzainqui, Ana, Andrés, Vicente, Seiki, Motoharu, Gisbert, Javier P., and Arroyo, Alicia G.

Abstract

Pathological angiogenesis contributes to cancer progression and chronic inflammatory diseases. In inflammatory bowel disease, the microvasculature expands by intussusceptive angiogenesis (IA), a poorly characterized mechanism involving increased blood flow and splitting of pre-existing capillaries. In this report, mice lacking the protease MT1-MMP in endothelial cells (MT1(i Delta EC)) presented limited IA in the capillary plexus of the colon mucosa assessed by 3D imaging during 1% DSS-induced colitis. This resulted in better tissue perfusion, preserved intestinal morphology, and milder disease activity index. Combined in vivo intravital microscopy and lentiviral rescue experiments with in vitro cell culture demonstrated that MT1-MMP activity in endothelial cells is required for vasodilation and IA, as well as for nitric oxide production via binding of the C-terminal fragment of MT1-MMP substrate thrombospondin-1 (TSP1) to CD47/alpha v beta 3 integrin. Moreover, TSP1 levels were significantly higher in serum from IBD patients and in vivo administration of an anti-MT1-MMP inhibitory antibody or a nonamer peptide spanning the alpha v beta 3 integrin binding site in TSP1 reduced IA during mouse colitis. Our results identify MT1-MMP as a new actor in inflammatory IA and a promising therapeutic target for inflammatory bowel disease.

Published
2019

2. Consensus guidelines for the use and interpretation of angiogenesis assays

Author

Nowak-Sliwinska, Patrycja, Alitalo, Kari, Allen, Elizabeth, Anisimov, Andrey, Aplin, Alfred C., Auerbach, Robert, Augustin, Hellmut G., Bates, David O., van Beijnum, Judy R., Bender, R. Hugh F., Bergers, Gabriele, Bikfalvi, Andreas, Bischoff, Joyce, Boeck, Barbara C., Brooks, Peter C., Bussolino, Federico, Cakir, Bertan, Carmeliet, Peter, Castranova, Daniel, Cimpean, Anca M., Cleaver, Ondine, Coukos, George, Davis, George E., De Palma, Michele, Dimberg, Anna, Dings, Ruud P. M., Djonov, Valentin, Dudley, Andrew C., Dufton, Neil P., Fendt, Sarah-Maria, Ferrara, Napoleone, Fruttiger, Marcus, Fukumura, Dai, Ghesquiere, Bart, Gong, Yan, Griffin, Robert J., Harris, Adrian L., Hughes, Christopher C. W., Hultgren, Nan W., Iruela-Arispe, M. Luisa, Irving, Melita, Jain, Rakesh K., Kalluri, Raghu, Kalucka, Joanna, Kerbel, Robert S., Kitajewski, Jan, Klaassen, Ingeborg, Kleinmann, Hynda K., Koolwijk, Pieter, Kuczynski, Elisabeth, Kwak, Brenda R., Marien, Koen, Melero-Martin, Juan M., Munn, Lance L., Nicosia, Roberto F., Noel, Agnes, Nurro, Jussi, Olsson, Anna-Karin, Petrova, Tatiana V., Pietras, Kristian, Pili, Roberto, Pollard, Jeffrey W., Post, Mark J., Quax, Paul H. A., Rabinovich, Gabriel A., Raica, Marius, Randi, Anna M., Ribatti, Domenico, Ruegg, Curzio, Schlingemann, Reinier O., Schulte-Merker, Stefan, Smith, Lois E. H., Song, Jonathan W., Stacker, Steven A., Stalin, Jimmy, Stratman, Amber N., Van de Velde, Maureen, van Hinsbergh, Victor W. M., Vermeulen, Peter B., Waltenberger, Johannes, Weinstein, Brant M., Xin, Hong, Yetkin-Arik, Bahar, Yla-Herttuala, Seppo, Yoder, Mervin C., Griffioen, Arjan W., Nowak-Sliwinska, Patrycja, Alitalo, Kari, Allen, Elizabeth, Anisimov, Andrey, Aplin, Alfred C., Auerbach, Robert, Augustin, Hellmut G., Bates, David O., van Beijnum, Judy R., Bender, R. Hugh F., Bergers, Gabriele, Bikfalvi, Andreas, Bischoff, Joyce, Boeck, Barbara C., Brooks, Peter C., Bussolino, Federico, Cakir, Bertan, Carmeliet, Peter, Castranova, Daniel, Cimpean, Anca M., Cleaver, Ondine, Coukos, George, Davis, George E., De Palma, Michele, Dimberg, Anna, Dings, Ruud P. M., Djonov, Valentin, Dudley, Andrew C., Dufton, Neil P., Fendt, Sarah-Maria, Ferrara, Napoleone, Fruttiger, Marcus, Fukumura, Dai, Ghesquiere, Bart, Gong, Yan, Griffin, Robert J., Harris, Adrian L., Hughes, Christopher C. W., Hultgren, Nan W., Iruela-Arispe, M. Luisa, Irving, Melita, Jain, Rakesh K., Kalluri, Raghu, Kalucka, Joanna, Kerbel, Robert S., Kitajewski, Jan, Klaassen, Ingeborg, Kleinmann, Hynda K., Koolwijk, Pieter, Kuczynski, Elisabeth, Kwak, Brenda R., Marien, Koen, Melero-Martin, Juan M., Munn, Lance L., Nicosia, Roberto F., Noel, Agnes, Nurro, Jussi, Olsson, Anna-Karin, Petrova, Tatiana V., Pietras, Kristian, Pili, Roberto, Pollard, Jeffrey W., Post, Mark J., Quax, Paul H. A., Rabinovich, Gabriel A., Raica, Marius, Randi, Anna M., Ribatti, Domenico, Ruegg, Curzio, Schlingemann, Reinier O., Schulte-Merker, Stefan, Smith, Lois E. H., Song, Jonathan W., Stacker, Steven A., Stalin, Jimmy, Stratman, Amber N., Van de Velde, Maureen, van Hinsbergh, Victor W. M., Vermeulen, Peter B., Waltenberger, Johannes, Weinstein, Brant M., Xin, Hong, Yetkin-Arik, Bahar, Yla-Herttuala, Seppo, Yoder, Mervin C., and Griffioen, Arjan W.

Abstract

The formation of new blood vessels, or angiogenesis, is a complex process that plays important roles in growth and development, tissue and organ regeneration, as well as numerous pathological conditions. Angiogenesis undergoes multiple discrete steps that can be individually evaluated and quantified by a large number of bioassays. These independent assessments hold advantages but also have limitations. This article describes in vivo, ex vivo, and in vitro bioassays that are available for the evaluation of angiogenesis and highlights critical aspects that are relevant for their execution and proper interpretation. As such, this collaborative work is the first edition of consensus guidelines on angiogenesis bioassays to serve for current and future reference.

Published
2018
Full Text
View/download PDF

3. Consensus guidelines for the use and interpretation of angiogenesis assays

Author

Nowak-Sliwinska, Patrycja, Alitalo, Kari, Allen, Elizabeth, Anisimov, Andrey, Aplin, Alfred C., Auerbach, Robert, Augustin, Hellmut G., Bates, David O., van Beijnum, Judy R., Bender, R. Hugh F., Bergers, Gabriele, Bikfalvi, Andreas, Bischoff, Joyce, Boeck, Barbara C., Brooks, Peter C., Bussolino, Federico, Cakir, Bertan, Carmeliet, Peter, Castranova, Daniel, Cimpean, Anca M., Cleaver, Ondine, Coukos, George, Davis, George E., De Palma, Michele, Dimberg, Anna, Dings, Ruud P. M., Djonov, Valentin, Dudley, Andrew C., Dufton, Neil P., Fendt, Sarah-Maria, Ferrara, Napoleone, Fruttiger, Marcus, Fukumura, Dai, Ghesquiere, Bart, Gong, Yan, Griffin, Robert J., Harris, Adrian L., Hughes, Christopher C. W., Hultgren, Nan W., Iruela-Arispe, M. Luisa, Irving, Melita, Jain, Rakesh K., Kalluri, Raghu, Kalucka, Joanna, Kerbel, Robert S., Kitajewski, Jan, Klaassen, Ingeborg, Kleinmann, Hynda K., Koolwijk, Pieter, Kuczynski, Elisabeth, Kwak, Brenda R., Marien, Koen, Melero-Martin, Juan M., Munn, Lance L., Nicosia, Roberto F., Noel, Agnes, Nurro, Jussi, Olsson, Anna-Karin, Petrova, Tatiana V., Pietras, Kristian, Pili, Roberto, Pollard, Jeffrey W., Post, Mark J., Quax, Paul H. A., Rabinovich, Gabriel A., Raica, Marius, Randi, Anna M., Ribatti, Domenico, Ruegg, Curzio, Schlingemann, Reinier O., Schulte-Merker, Stefan, Smith, Lois E. H., Song, Jonathan W., Stacker, Steven A., Stalin, Jimmy, Stratman, Amber N., Van de Velde, Maureen, van Hinsbergh, Victor W. M., Vermeulen, Peter B., Waltenberger, Johannes, Weinstein, Brant M., Xin, Hong, Yetkin-Arik, Bahar, Yla-Herttuala, Seppo, Yoder, Mervin C., Griffioen, Arjan W., Nowak-Sliwinska, Patrycja, Alitalo, Kari, Allen, Elizabeth, Anisimov, Andrey, Aplin, Alfred C., Auerbach, Robert, Augustin, Hellmut G., Bates, David O., van Beijnum, Judy R., Bender, R. Hugh F., Bergers, Gabriele, Bikfalvi, Andreas, Bischoff, Joyce, Boeck, Barbara C., Brooks, Peter C., Bussolino, Federico, Cakir, Bertan, Carmeliet, Peter, Castranova, Daniel, Cimpean, Anca M., Cleaver, Ondine, Coukos, George, Davis, George E., De Palma, Michele, Dimberg, Anna, Dings, Ruud P. M., Djonov, Valentin, Dudley, Andrew C., Dufton, Neil P., Fendt, Sarah-Maria, Ferrara, Napoleone, Fruttiger, Marcus, Fukumura, Dai, Ghesquiere, Bart, Gong, Yan, Griffin, Robert J., Harris, Adrian L., Hughes, Christopher C. W., Hultgren, Nan W., Iruela-Arispe, M. Luisa, Irving, Melita, Jain, Rakesh K., Kalluri, Raghu, Kalucka, Joanna, Kerbel, Robert S., Kitajewski, Jan, Klaassen, Ingeborg, Kleinmann, Hynda K., Koolwijk, Pieter, Kuczynski, Elisabeth, Kwak, Brenda R., Marien, Koen, Melero-Martin, Juan M., Munn, Lance L., Nicosia, Roberto F., Noel, Agnes, Nurro, Jussi, Olsson, Anna-Karin, Petrova, Tatiana V., Pietras, Kristian, Pili, Roberto, Pollard, Jeffrey W., Post, Mark J., Quax, Paul H. A., Rabinovich, Gabriel A., Raica, Marius, Randi, Anna M., Ribatti, Domenico, Ruegg, Curzio, Schlingemann, Reinier O., Schulte-Merker, Stefan, Smith, Lois E. H., Song, Jonathan W., Stacker, Steven A., Stalin, Jimmy, Stratman, Amber N., Van de Velde, Maureen, van Hinsbergh, Victor W. M., Vermeulen, Peter B., Waltenberger, Johannes, Weinstein, Brant M., Xin, Hong, Yetkin-Arik, Bahar, Yla-Herttuala, Seppo, Yoder, Mervin C., and Griffioen, Arjan W.

Abstract

The formation of new blood vessels, or angiogenesis, is a complex process that plays important roles in growth and development, tissue and organ regeneration, as well as numerous pathological conditions. Angiogenesis undergoes multiple discrete steps that can be individually evaluated and quantified by a large number of bioassays. These independent assessments hold advantages but also have limitations. This article describes in vivo, ex vivo, and in vitro bioassays that are available for the evaluation of angiogenesis and highlights critical aspects that are relevant for their execution and proper interpretation. As such, this collaborative work is the first edition of consensus guidelines on angiogenesis bioassays to serve for current and future reference.

Published
2018
Full Text
View/download PDF

4. Consensus guidelines for the use and interpretation of angiogenesis assays.

Author

Nowak-Sliwinska, Patrycja, Nowak-Sliwinska, Patrycja, Alitalo, Kari, Allen, Elizabeth, Anisimov, Andrey, Aplin, Alfred C, Auerbach, Robert, Augustin, Hellmut G, Bates, David O, van Beijnum, Judy R, Bender, R Hugh F, Bergers, Gabriele, Bikfalvi, Andreas, Bischoff, Joyce, Böck, Barbara C, Brooks, Peter C, Bussolino, Federico, Cakir, Bertan, Carmeliet, Peter, Castranova, Daniel, Cimpean, Anca M, Cleaver, Ondine, Coukos, George, Davis, George E, De Palma, Michele, Dimberg, Anna, Dings, Ruud PM, Djonov, Valentin, Dudley, Andrew C, Dufton, Neil P, Fendt, Sarah-Maria, Ferrara, Napoleone, Fruttiger, Marcus, Fukumura, Dai, Ghesquière, Bart, Gong, Yan, Griffin, Robert J, Harris, Adrian L, Hughes, Christopher CW, Hultgren, Nan W, Iruela-Arispe, M Luisa, Irving, Melita, Jain, Rakesh K, Kalluri, Raghu, Kalucka, Joanna, Kerbel, Robert S, Kitajewski, Jan, Klaassen, Ingeborg, Kleinmann, Hynda K, Koolwijk, Pieter, Kuczynski, Elisabeth, Kwak, Brenda R, Marien, Koen, Melero-Martin, Juan M, Munn, Lance L, Nicosia, Roberto F, Noel, Agnes, Nurro, Jussi, Olsson, Anna-Karin, Petrova, Tatiana V, Pietras, Kristian, Pili, Roberto, Pollard, Jeffrey W, Post, Mark J, Quax, Paul HA, Rabinovich, Gabriel A, Raica, Marius, Randi, Anna M, Ribatti, Domenico, Ruegg, Curzio, Schlingemann, Reinier O, Schulte-Merker, Stefan, Smith, Lois EH, Song, Jonathan W, Stacker, Steven A, Stalin, Jimmy, Stratman, Amber N, Van de Velde, Maureen, van Hinsbergh, Victor WM, Vermeulen, Peter B, Waltenberger, Johannes, Weinstein, Brant M, Xin, Hong, Yetkin-Arik, Bahar, Yla-Herttuala, Seppo, Yoder, Mervin C, Griffioen, Arjan W, Nowak-Sliwinska, Patrycja, Nowak-Sliwinska, Patrycja, Alitalo, Kari, Allen, Elizabeth, Anisimov, Andrey, Aplin, Alfred C, Auerbach, Robert, Augustin, Hellmut G, Bates, David O, van Beijnum, Judy R, Bender, R Hugh F, Bergers, Gabriele, Bikfalvi, Andreas, Bischoff, Joyce, Böck, Barbara C, Brooks, Peter C, Bussolino, Federico, Cakir, Bertan, Carmeliet, Peter, Castranova, Daniel, Cimpean, Anca M, Cleaver, Ondine, Coukos, George, Davis, George E, De Palma, Michele, Dimberg, Anna, Dings, Ruud PM, Djonov, Valentin, Dudley, Andrew C, Dufton, Neil P, Fendt, Sarah-Maria, Ferrara, Napoleone, Fruttiger, Marcus, Fukumura, Dai, Ghesquière, Bart, Gong, Yan, Griffin, Robert J, Harris, Adrian L, Hughes, Christopher CW, Hultgren, Nan W, Iruela-Arispe, M Luisa, Irving, Melita, Jain, Rakesh K, Kalluri, Raghu, Kalucka, Joanna, Kerbel, Robert S, Kitajewski, Jan, Klaassen, Ingeborg, Kleinmann, Hynda K, Koolwijk, Pieter, Kuczynski, Elisabeth, Kwak, Brenda R, Marien, Koen, Melero-Martin, Juan M, Munn, Lance L, Nicosia, Roberto F, Noel, Agnes, Nurro, Jussi, Olsson, Anna-Karin, Petrova, Tatiana V, Pietras, Kristian, Pili, Roberto, Pollard, Jeffrey W, Post, Mark J, Quax, Paul HA, Rabinovich, Gabriel A, Raica, Marius, Randi, Anna M, Ribatti, Domenico, Ruegg, Curzio, Schlingemann, Reinier O, Schulte-Merker, Stefan, Smith, Lois EH, Song, Jonathan W, Stacker, Steven A, Stalin, Jimmy, Stratman, Amber N, Van de Velde, Maureen, van Hinsbergh, Victor WM, Vermeulen, Peter B, Waltenberger, Johannes, Weinstein, Brant M, Xin, Hong, Yetkin-Arik, Bahar, Yla-Herttuala, Seppo, Yoder, Mervin C, and Griffioen, Arjan W

Abstract

The formation of new blood vessels, or angiogenesis, is a complex process that plays important roles in growth and development, tissue and organ regeneration, as well as numerous pathological conditions. Angiogenesis undergoes multiple discrete steps that can be individually evaluated and quantified by a large number of bioassays. These independent assessments hold advantages but also have limitations. This article describes in vivo, ex vivo, and in vitro bioassays that are available for the evaluation of angiogenesis and highlights critical aspects that are relevant for their execution and proper interpretation. As such, this collaborative work is the first edition of consensus guidelines on angiogenesis bioassays to serve for current and future reference.

Published
2018

5. Consensus guidelines for the use and interpretation of angiogenesis assays.

Author

Nowak-Sliwinska, Patrycja, Nowak-Sliwinska, Patrycja, Alitalo, Kari, Allen, Elizabeth, Anisimov, Andrey, Aplin, Alfred C, Auerbach, Robert, Augustin, Hellmut G, Bates, David O, van Beijnum, Judy R, Bender, R Hugh F, Bergers, Gabriele, Bikfalvi, Andreas, Bischoff, Joyce, Böck, Barbara C, Brooks, Peter C, Bussolino, Federico, Cakir, Bertan, Carmeliet, Peter, Castranova, Daniel, Cimpean, Anca M, Cleaver, Ondine, Coukos, George, Davis, George E, De Palma, Michele, Dimberg, Anna, Dings, Ruud PM, Djonov, Valentin, Dudley, Andrew C, Dufton, Neil P, Fendt, Sarah-Maria, Ferrara, Napoleone, Fruttiger, Marcus, Fukumura, Dai, Ghesquière, Bart, Gong, Yan, Griffin, Robert J, Harris, Adrian L, Hughes, Christopher CW, Hultgren, Nan W, Iruela-Arispe, M Luisa, Irving, Melita, Jain, Rakesh K, Kalluri, Raghu, Kalucka, Joanna, Kerbel, Robert S, Kitajewski, Jan, Klaassen, Ingeborg, Kleinmann, Hynda K, Koolwijk, Pieter, Kuczynski, Elisabeth, Kwak, Brenda R, Marien, Koen, Melero-Martin, Juan M, Munn, Lance L, Nicosia, Roberto F, Noel, Agnes, Nurro, Jussi, Olsson, Anna-Karin, Petrova, Tatiana V, Pietras, Kristian, Pili, Roberto, Pollard, Jeffrey W, Post, Mark J, Quax, Paul HA, Rabinovich, Gabriel A, Raica, Marius, Randi, Anna M, Ribatti, Domenico, Ruegg, Curzio, Schlingemann, Reinier O, Schulte-Merker, Stefan, Smith, Lois EH, Song, Jonathan W, Stacker, Steven A, Stalin, Jimmy, Stratman, Amber N, Van de Velde, Maureen, van Hinsbergh, Victor WM, Vermeulen, Peter B, Waltenberger, Johannes, Weinstein, Brant M, Xin, Hong, Yetkin-Arik, Bahar, Yla-Herttuala, Seppo, Yoder, Mervin C, Griffioen, Arjan W, Nowak-Sliwinska, Patrycja, Nowak-Sliwinska, Patrycja, Alitalo, Kari, Allen, Elizabeth, Anisimov, Andrey, Aplin, Alfred C, Auerbach, Robert, Augustin, Hellmut G, Bates, David O, van Beijnum, Judy R, Bender, R Hugh F, Bergers, Gabriele, Bikfalvi, Andreas, Bischoff, Joyce, Böck, Barbara C, Brooks, Peter C, Bussolino, Federico, Cakir, Bertan, Carmeliet, Peter, Castranova, Daniel, Cimpean, Anca M, Cleaver, Ondine, Coukos, George, Davis, George E, De Palma, Michele, Dimberg, Anna, Dings, Ruud PM, Djonov, Valentin, Dudley, Andrew C, Dufton, Neil P, Fendt, Sarah-Maria, Ferrara, Napoleone, Fruttiger, Marcus, Fukumura, Dai, Ghesquière, Bart, Gong, Yan, Griffin, Robert J, Harris, Adrian L, Hughes, Christopher CW, Hultgren, Nan W, Iruela-Arispe, M Luisa, Irving, Melita, Jain, Rakesh K, Kalluri, Raghu, Kalucka, Joanna, Kerbel, Robert S, Kitajewski, Jan, Klaassen, Ingeborg, Kleinmann, Hynda K, Koolwijk, Pieter, Kuczynski, Elisabeth, Kwak, Brenda R, Marien, Koen, Melero-Martin, Juan M, Munn, Lance L, Nicosia, Roberto F, Noel, Agnes, Nurro, Jussi, Olsson, Anna-Karin, Petrova, Tatiana V, Pietras, Kristian, Pili, Roberto, Pollard, Jeffrey W, Post, Mark J, Quax, Paul HA, Rabinovich, Gabriel A, Raica, Marius, Randi, Anna M, Ribatti, Domenico, Ruegg, Curzio, Schlingemann, Reinier O, Schulte-Merker, Stefan, Smith, Lois EH, Song, Jonathan W, Stacker, Steven A, Stalin, Jimmy, Stratman, Amber N, Van de Velde, Maureen, van Hinsbergh, Victor WM, Vermeulen, Peter B, Waltenberger, Johannes, Weinstein, Brant M, Xin, Hong, Yetkin-Arik, Bahar, Yla-Herttuala, Seppo, Yoder, Mervin C, and Griffioen, Arjan W

Abstract

The formation of new blood vessels, or angiogenesis, is a complex process that plays important roles in growth and development, tissue and organ regeneration, as well as numerous pathological conditions. Angiogenesis undergoes multiple discrete steps that can be individually evaluated and quantified by a large number of bioassays. These independent assessments hold advantages but also have limitations. This article describes in vivo, ex vivo, and in vitro bioassays that are available for the evaluation of angiogenesis and highlights critical aspects that are relevant for their execution and proper interpretation. As such, this collaborative work is the first edition of consensus guidelines on angiogenesis bioassays to serve for current and future reference.

Published
2018

6. Consensus guidelines for the use and interpretation of angiogenesis assays

Author

Nowak-Sliwinska, Patrycja, Alitalo, Kari, Allen, Elizabeth, Anisimov, Andrey, Aplin, Alfred C., Auerbach, Robert, Augustin, Hellmut G., Bates, David O., van Beijnum, Judy R., Bender, R. Hugh F., Bergers, Gabriele, Bikfalvi, Andreas, Bischoff, Joyce, Boeck, Barbara C., Brooks, Peter C., Bussolino, Federico, Cakir, Bertan, Carmeliet, Peter, Castranova, Daniel, Cimpean, Anca M., Cleaver, Ondine, Coukos, George, Davis, George E., De Palma, Michele, Dimberg, Anna, Dings, Ruud P. M., Djonov, Valentin, Dudley, Andrew C., Dufton, Neil P., Fendt, Sarah-Maria, Ferrara, Napoleone, Fruttiger, Marcus, Fukumura, Dai, Ghesquiere, Bart, Gong, Yan, Griffin, Robert J., Harris, Adrian L., Hughes, Christopher C. W., Hultgren, Nan W., Iruela-Arispe, M. Luisa, Irving, Melita, Jain, Rakesh K., Kalluri, Raghu, Kalucka, Joanna, Kerbel, Robert S., Kitajewski, Jan, Klaassen, Ingeborg, Kleinmann, Hynda K., Koolwijk, Pieter, Kuczynski, Elisabeth, Kwak, Brenda R., Marien, Koen, Melero-Martin, Juan M., Munn, Lance L., Nicosia, Roberto F., Noel, Agnes, Nurro, Jussi, Olsson, Anna-Karin, Petrova, Tatiana V., Pietras, Kristian, Pili, Roberto, Pollard, Jeffrey W., Post, Mark J., Quax, Paul H. A., Rabinovich, Gabriel A., Raica, Marius, Randi, Anna M., Ribatti, Domenico, Ruegg, Curzio, Schlingemann, Reinier O., Schulte-Merker, Stefan, Smith, Lois E. H., Song, Jonathan W., Stacker, Steven A., Stalin, Jimmy, Stratman, Amber N., Van de Velde, Maureen, van Hinsbergh, Victor W. M., Vermeulen, Peter B., Waltenberger, Johannes, Weinstein, Brant M., Xin, Hong, Yetkin-Arik, Bahar, Yla-Herttuala, Seppo, Yoder, Mervin C., Griffioen, Arjan W., Nowak-Sliwinska, Patrycja, Alitalo, Kari, Allen, Elizabeth, Anisimov, Andrey, Aplin, Alfred C., Auerbach, Robert, Augustin, Hellmut G., Bates, David O., van Beijnum, Judy R., Bender, R. Hugh F., Bergers, Gabriele, Bikfalvi, Andreas, Bischoff, Joyce, Boeck, Barbara C., Brooks, Peter C., Bussolino, Federico, Cakir, Bertan, Carmeliet, Peter, Castranova, Daniel, Cimpean, Anca M., Cleaver, Ondine, Coukos, George, Davis, George E., De Palma, Michele, Dimberg, Anna, Dings, Ruud P. M., Djonov, Valentin, Dudley, Andrew C., Dufton, Neil P., Fendt, Sarah-Maria, Ferrara, Napoleone, Fruttiger, Marcus, Fukumura, Dai, Ghesquiere, Bart, Gong, Yan, Griffin, Robert J., Harris, Adrian L., Hughes, Christopher C. W., Hultgren, Nan W., Iruela-Arispe, M. Luisa, Irving, Melita, Jain, Rakesh K., Kalluri, Raghu, Kalucka, Joanna, Kerbel, Robert S., Kitajewski, Jan, Klaassen, Ingeborg, Kleinmann, Hynda K., Koolwijk, Pieter, Kuczynski, Elisabeth, Kwak, Brenda R., Marien, Koen, Melero-Martin, Juan M., Munn, Lance L., Nicosia, Roberto F., Noel, Agnes, Nurro, Jussi, Olsson, Anna-Karin, Petrova, Tatiana V., Pietras, Kristian, Pili, Roberto, Pollard, Jeffrey W., Post, Mark J., Quax, Paul H. A., Rabinovich, Gabriel A., Raica, Marius, Randi, Anna M., Ribatti, Domenico, Ruegg, Curzio, Schlingemann, Reinier O., Schulte-Merker, Stefan, Smith, Lois E. H., Song, Jonathan W., Stacker, Steven A., Stalin, Jimmy, Stratman, Amber N., Van de Velde, Maureen, van Hinsbergh, Victor W. M., Vermeulen, Peter B., Waltenberger, Johannes, Weinstein, Brant M., Xin, Hong, Yetkin-Arik, Bahar, Yla-Herttuala, Seppo, Yoder, Mervin C., and Griffioen, Arjan W.

Abstract

The formation of new blood vessels, or angiogenesis, is a complex process that plays important roles in growth and development, tissue and organ regeneration, as well as numerous pathological conditions. Angiogenesis undergoes multiple discrete steps that can be individually evaluated and quantified by a large number of bioassays. These independent assessments hold advantages but also have limitations. This article describes in vivo, ex vivo, and in vitro bioassays that are available for the evaluation of angiogenesis and highlights critical aspects that are relevant for their execution and proper interpretation. As such, this collaborative work is the first edition of consensus guidelines on angiogenesis bioassays to serve for current and future reference.

Published
2018
Full Text
View/download PDF

7. Consensus guidelines for the use and interpretation of angiogenesis assays

Author

Nowak-Sliwinska, Patrycja, Alitalo, Kari, Allen, Elizabeth, Anisimov, Andrey, Aplin, Alfred C., Auerbach, Robert, Augustin, Hellmut G., Bates, David O., van Beijnum, Judy R., Bender, R. Hugh F., Bergers, Gabriele, Bikfalvi, Andreas, Bischoff, Joyce, Boeck, Barbara C., Brooks, Peter C., Bussolino, Federico, Cakir, Bertan, Carmeliet, Peter, Castranova, Daniel, Cimpean, Anca M., Cleaver, Ondine, Coukos, George, Davis, George E., De Palma, Michele, Dimberg, Anna, Dings, Ruud P. M., Djonov, Valentin, Dudley, Andrew C., Dufton, Neil P., Fendt, Sarah-Maria, Ferrara, Napoleone, Fruttiger, Marcus, Fukumura, Dai, Ghesquiere, Bart, Gong, Yan, Griffin, Robert J., Harris, Adrian L., Hughes, Christopher C. W., Hultgren, Nan W., Iruela-Arispe, M. Luisa, Irving, Melita, Jain, Rakesh K., Kalluri, Raghu, Kalucka, Joanna, Kerbel, Robert S., Kitajewski, Jan, Klaassen, Ingeborg, Kleinmann, Hynda K., Koolwijk, Pieter, Kuczynski, Elisabeth, Kwak, Brenda R., Marien, Koen, Melero-Martin, Juan M., Munn, Lance L., Nicosia, Roberto F., Noel, Agnes, Nurro, Jussi, Olsson, Anna-Karin, Petrova, Tatiana V., Pietras, Kristian, Pili, Roberto, Pollard, Jeffrey W., Post, Mark J., Quax, Paul H. A., Rabinovich, Gabriel A., Raica, Marius, Randi, Anna M., Ribatti, Domenico, Ruegg, Curzio, Schlingemann, Reinier O., Schulte-Merker, Stefan, Smith, Lois E. H., Song, Jonathan W., Stacker, Steven A., Stalin, Jimmy, Stratman, Amber N., Van de Velde, Maureen, van Hinsbergh, Victor W. M., Vermeulen, Peter B., Waltenberger, Johannes, Weinstein, Brant M., Xin, Hong, Yetkin-Arik, Bahar, Yla-Herttuala, Seppo, Yoder, Mervin C., Griffioen, Arjan W., Nowak-Sliwinska, Patrycja, Alitalo, Kari, Allen, Elizabeth, Anisimov, Andrey, Aplin, Alfred C., Auerbach, Robert, Augustin, Hellmut G., Bates, David O., van Beijnum, Judy R., Bender, R. Hugh F., Bergers, Gabriele, Bikfalvi, Andreas, Bischoff, Joyce, Boeck, Barbara C., Brooks, Peter C., Bussolino, Federico, Cakir, Bertan, Carmeliet, Peter, Castranova, Daniel, Cimpean, Anca M., Cleaver, Ondine, Coukos, George, Davis, George E., De Palma, Michele, Dimberg, Anna, Dings, Ruud P. M., Djonov, Valentin, Dudley, Andrew C., Dufton, Neil P., Fendt, Sarah-Maria, Ferrara, Napoleone, Fruttiger, Marcus, Fukumura, Dai, Ghesquiere, Bart, Gong, Yan, Griffin, Robert J., Harris, Adrian L., Hughes, Christopher C. W., Hultgren, Nan W., Iruela-Arispe, M. Luisa, Irving, Melita, Jain, Rakesh K., Kalluri, Raghu, Kalucka, Joanna, Kerbel, Robert S., Kitajewski, Jan, Klaassen, Ingeborg, Kleinmann, Hynda K., Koolwijk, Pieter, Kuczynski, Elisabeth, Kwak, Brenda R., Marien, Koen, Melero-Martin, Juan M., Munn, Lance L., Nicosia, Roberto F., Noel, Agnes, Nurro, Jussi, Olsson, Anna-Karin, Petrova, Tatiana V., Pietras, Kristian, Pili, Roberto, Pollard, Jeffrey W., Post, Mark J., Quax, Paul H. A., Rabinovich, Gabriel A., Raica, Marius, Randi, Anna M., Ribatti, Domenico, Ruegg, Curzio, Schlingemann, Reinier O., Schulte-Merker, Stefan, Smith, Lois E. H., Song, Jonathan W., Stacker, Steven A., Stalin, Jimmy, Stratman, Amber N., Van de Velde, Maureen, van Hinsbergh, Victor W. M., Vermeulen, Peter B., Waltenberger, Johannes, Weinstein, Brant M., Xin, Hong, Yetkin-Arik, Bahar, Yla-Herttuala, Seppo, Yoder, Mervin C., and Griffioen, Arjan W.

Abstract

The formation of new blood vessels, or angiogenesis, is a complex process that plays important roles in growth and development, tissue and organ regeneration, as well as numerous pathological conditions. Angiogenesis undergoes multiple discrete steps that can be individually evaluated and quantified by a large number of bioassays. These independent assessments hold advantages but also have limitations. This article describes in vivo, ex vivo, and in vitro bioassays that are available for the evaluation of angiogenesis and highlights critical aspects that are relevant for their execution and proper interpretation. As such, this collaborative work is the first edition of consensus guidelines on angiogenesis bioassays to serve for current and future reference.

Published
2018
Full Text
View/download PDF

8. Consensus guidelines for the use and interpretation of angiogenesis assays

Author

Nowak-Sliwinska, Patrycja, Alitalo, Kari, Allen, Elizabeth, Anisimov, Andrey, Aplin, Alfred C., Auerbach, Robert, Augustin, Hellmut G., Bates, David O., van Beijnum, Judy R., Bender, R. Hugh F., Bergers, Gabriele, Bikfalvi, Andreas, Bischoff, Joyce, Boeck, Barbara C., Brooks, Peter C., Bussolino, Federico, Cakir, Bertan, Carmeliet, Peter, Castranova, Daniel, Cimpean, Anca M., Cleaver, Ondine, Coukos, George, Davis, George E., De Palma, Michele, Dimberg, Anna, Dings, Ruud P. M., Djonov, Valentin, Dudley, Andrew C., Dufton, Neil P., Fendt, Sarah-Maria, Ferrara, Napoleone, Fruttiger, Marcus, Fukumura, Dai, Ghesquiere, Bart, Gong, Yan, Griffin, Robert J., Harris, Adrian L., Hughes, Christopher C. W., Hultgren, Nan W., Iruela-Arispe, M. Luisa, Irving, Melita, Jain, Rakesh K., Kalluri, Raghu, Kalucka, Joanna, Kerbel, Robert S., Kitajewski, Jan, Klaassen, Ingeborg, Kleinmann, Hynda K., Koolwijk, Pieter, Kuczynski, Elisabeth, Kwak, Brenda R., Marien, Koen, Melero-Martin, Juan M., Munn, Lance L., Nicosia, Roberto F., Noel, Agnes, Nurro, Jussi, Olsson, Anna-Karin, Petrova, Tatiana V., Pietras, Kristian, Pili, Roberto, Pollard, Jeffrey W., Post, Mark J., Quax, Paul H. A., Rabinovich, Gabriel A., Raica, Marius, Randi, Anna M., Ribatti, Domenico, Ruegg, Curzio, Schlingemann, Reinier O., Schulte-Merker, Stefan, Smith, Lois E. H., Song, Jonathan W., Stacker, Steven A., Stalin, Jimmy, Stratman, Amber N., Van de Velde, Maureen, van Hinsbergh, Victor W. M., Vermeulen, Peter B., Waltenberger, Johannes, Weinstein, Brant M., Xin, Hong, Yetkin-Arik, Bahar, Yla-Herttuala, Seppo, Yoder, Mervin C., Griffioen, Arjan W., Nowak-Sliwinska, Patrycja, Alitalo, Kari, Allen, Elizabeth, Anisimov, Andrey, Aplin, Alfred C., Auerbach, Robert, Augustin, Hellmut G., Bates, David O., van Beijnum, Judy R., Bender, R. Hugh F., Bergers, Gabriele, Bikfalvi, Andreas, Bischoff, Joyce, Boeck, Barbara C., Brooks, Peter C., Bussolino, Federico, Cakir, Bertan, Carmeliet, Peter, Castranova, Daniel, Cimpean, Anca M., Cleaver, Ondine, Coukos, George, Davis, George E., De Palma, Michele, Dimberg, Anna, Dings, Ruud P. M., Djonov, Valentin, Dudley, Andrew C., Dufton, Neil P., Fendt, Sarah-Maria, Ferrara, Napoleone, Fruttiger, Marcus, Fukumura, Dai, Ghesquiere, Bart, Gong, Yan, Griffin, Robert J., Harris, Adrian L., Hughes, Christopher C. W., Hultgren, Nan W., Iruela-Arispe, M. Luisa, Irving, Melita, Jain, Rakesh K., Kalluri, Raghu, Kalucka, Joanna, Kerbel, Robert S., Kitajewski, Jan, Klaassen, Ingeborg, Kleinmann, Hynda K., Koolwijk, Pieter, Kuczynski, Elisabeth, Kwak, Brenda R., Marien, Koen, Melero-Martin, Juan M., Munn, Lance L., Nicosia, Roberto F., Noel, Agnes, Nurro, Jussi, Olsson, Anna-Karin, Petrova, Tatiana V., Pietras, Kristian, Pili, Roberto, Pollard, Jeffrey W., Post, Mark J., Quax, Paul H. A., Rabinovich, Gabriel A., Raica, Marius, Randi, Anna M., Ribatti, Domenico, Ruegg, Curzio, Schlingemann, Reinier O., Schulte-Merker, Stefan, Smith, Lois E. H., Song, Jonathan W., Stacker, Steven A., Stalin, Jimmy, Stratman, Amber N., Van de Velde, Maureen, van Hinsbergh, Victor W. M., Vermeulen, Peter B., Waltenberger, Johannes, Weinstein, Brant M., Xin, Hong, Yetkin-Arik, Bahar, Yla-Herttuala, Seppo, Yoder, Mervin C., and Griffioen, Arjan W.

Abstract

The formation of new blood vessels, or angiogenesis, is a complex process that plays important roles in growth and development, tissue and organ regeneration, as well as numerous pathological conditions. Angiogenesis undergoes multiple discrete steps that can be individually evaluated and quantified by a large number of bioassays. These independent assessments hold advantages but also have limitations. This article describes in vivo, ex vivo, and in vitro bioassays that are available for the evaluation of angiogenesis and highlights critical aspects that are relevant for their execution and proper interpretation. As such, this collaborative work is the first edition of consensus guidelines on angiogenesis bioassays to serve for current and future reference.

Published
2018
Full Text
View/download PDF

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