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1. Using microbiological data to improve the use of antibiotics for respiratory tract infections: A protocol for an individual patient data meta-analysis

Author

HAG Infectieziekten, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Boateng, Irene, Stuart, Beth, Becque, Taeko, Barrett, Bruce, Bostock, Jennifer, Bruyndonckx, Robin, Carr-Knox, Lucy, Ciccone, Emily J, Coenen, Samuel, Ebell, Mark, Gillespie, David, Hayward, Gail, Hedin, Katarina, Hood, Kerenza, Lau, Tin Man Mandy, Little, Paul, Merenstein, Dan, Mulogo, Edgar, Ordóñez-Mena, Jose, Muir, Peter, Samuel, Kirsty, Shaikh, Nader, Tonner, Sharon, van der Velden, Alike W, Verheij, Theo, Wang, Kay, Hay, Alastair D, Francis, Nick, HAG Infectieziekten, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Boateng, Irene, Stuart, Beth, Becque, Taeko, Barrett, Bruce, Bostock, Jennifer, Bruyndonckx, Robin, Carr-Knox, Lucy, Ciccone, Emily J, Coenen, Samuel, Ebell, Mark, Gillespie, David, Hayward, Gail, Hedin, Katarina, Hood, Kerenza, Lau, Tin Man Mandy, Little, Paul, Merenstein, Dan, Mulogo, Edgar, Ordóñez-Mena, Jose, Muir, Peter, Samuel, Kirsty, Shaikh, Nader, Tonner, Sharon, van der Velden, Alike W, Verheij, Theo, Wang, Kay, Hay, Alastair D, and Francis, Nick

Published
2023

2. Using microbiological data to improve the use of antibiotics for respiratory tract infections: A protocol for an individual patient data meta-analysis

Author

Boateng, Irene, Stuart, Beth, Becque, Taeko, Barrett, Bruce, Bostock, Jennifer, Bruyndonckx, Robin, Carr-Knox, Lucy, Ciccone, Emily J., Coenen, Samuel, Ebell, Mark, Gillespie, David, Hayward, Gail, Hedin, Katarina, Hood, Kerenza, Lau, Tin Man Mandy, Little, Paul, Merenstein, Dan, Mulogo, Edgar, Ordonez-Mena, Jose, Muir, Peter, Samuel, Kirsty, Shaikh, Nader, Tonner, Sharon, van der Velden, Alike W., Verheij, Theo, Wang, Kay, Hay, Alastair D., Francis, Nick, Boateng, Irene, Stuart, Beth, Becque, Taeko, Barrett, Bruce, Bostock, Jennifer, Bruyndonckx, Robin, Carr-Knox, Lucy, Ciccone, Emily J., Coenen, Samuel, Ebell, Mark, Gillespie, David, Hayward, Gail, Hedin, Katarina, Hood, Kerenza, Lau, Tin Man Mandy, Little, Paul, Merenstein, Dan, Mulogo, Edgar, Ordonez-Mena, Jose, Muir, Peter, Samuel, Kirsty, Shaikh, Nader, Tonner, Sharon, van der Velden, Alike W., Verheij, Theo, Wang, Kay, Hay, Alastair D., and Francis, Nick

Abstract

BackgroundResistance to antibiotics is rising and threatens future antibiotic effectiveness. 'Antibiotic targeting' ensures patients who may benefit from antibiotics receive them, while being safely withheld from those who may not. Point-of-care tests may assist with antibiotic targeting by allowing primary care clinicians to establish if symptomatic patients have a viral, bacterial, combined, or no infection. However, because organisms can be harmlessly carried, it is important to know if the presence of the virus/bacteria is related to the illness for which the patient is being assessed. One way to do this is to look for associations with more severe/prolonged symptoms and test results. Previous research to answer this question for acute respiratory tract infections has given conflicting results with studies has not having enough participants to provide statistical confidence.AimTo undertake a synthesis of IPD from both randomised controlled trials (RCTs) and observational cohort studies of respiratory tract infections (RTI) in order to investigate the prognostic value of microbiological data in addition to, or instead of, clinical symptoms and signs.MethodsA systematic search of Cochrane Central Register of Controlled Trials, Ovid Medline and Ovid Embase will be carried out for studies of acute respiratory infection in primary care settings. The outcomes of interest are duration of disease, severity of disease, repeated consultation with new/worsening illness and complications requiring hospitalisation. Authors of eligible studies will be contacted to provide anonymised individual participant data. The data will be harmonised and aggregated. Multilevel regression analysis will be conducted to determine key outcome measures for different potential pathogens and whether these offer any additional information on prognosis beyond clinical symptoms and signs.Trial registrationPROSPERO Registration number: CRD42023376769., Funding Agencies|National Institute for Health and Care Research (NIHR) School for Primary Care Research [589]

Published
2023
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3. Effectiveness of the Strengthening Families Programme in the UK at preventing substance misuse in 10–14 year-olds: A pragmatic randomised controlled trial

Author

Segrott, Jeremy, Gillespie, David, Lau, Mandy, Holliday, Jo, Murphy, Simon, Foxcroft, David, Hood, Kerenza, Scourfield, Jonathan, Phillips, Ceri, Roberts, Zoe, Rothwell, Heather, Hurlow, Claire, Moore, Laurence, Segrott, Jeremy, Gillespie, David, Lau, Mandy, Holliday, Jo, Murphy, Simon, Foxcroft, David, Hood, Kerenza, Scourfield, Jonathan, Phillips, Ceri, Roberts, Zoe, Rothwell, Heather, Hurlow, Claire, and Moore, Laurence

Abstract

Objectives. The Strengthening Families Programme 10–14 (SFP10-14) is a USA-developed universal group-based intervention aiming to prevent substance misuse by strengthening protective factors within the family. This study evaluated a proportionate universal implementation of the adapted UK version (SFP10-14UK) which brought together families identified as likely/not likely to experience/present challenges within a group setting. Design. Pragmatic cluster-randomised controlled effectiveness trial, with families as the unit of randomisation and embedded process and economic evaluations. Setting. The study took place in seven counties of Wales, UK. Participants. 715 families (919 parents/carers, 931 young people) were randomised. Interventions. Families randomised to the intervention arm received the SFP10-14 comprising seven weekly sessions. Families in intervention and control arms received existing services as normal. Outcome measures. Primary outcomes were the number of occasions young people reported drinking alcohol in the last 30 days; and drunkenness during the same period, dichotomised as ‘never’ and ‘1–2 times or more’. Secondary outcomes examined alcohol/tobacco/substance behaviours including: cannabis use; weekly smoking (validated by salivary cotinine measures); age of alcohol initiation; frequency of drinking >5 drinks in a row; frequency of different types of alcoholic drinks; alcohol-related problems. Retention: primary analysis included 746 young people (80.1%) (alcohol consumption) and 732 young people (78.6%) (drunkenness). Results. There was no evidence of statistically significant between-group differences 2 years after randomisation for primary outcomes (young people’s alcohol consumption in the last 30 days adjusted OR=1.11, 95% CI 0.72 to 1.71, p=0.646; drunkenness in the last 30 days adjusted OR=1.46, 95% CI 0.83 to 2.55, p=0.185). There were no statistically significant between-group differences for other substance use outcomes, or those relati

Published
2022

4. Effectiveness of the Strengthening Families Programme in the UK at preventing substance misuse in 10–14 year-olds: A pragmatic randomised controlled trial

Author

Segrott, Jeremy, Gillespie, David, Lau, Mandy, Holliday, Jo, Murphy, Simon, Foxcroft, David, Hood, Kerenza, Scourfield, Jonathan, Phillips, Ceri, Roberts, Zoe, Rothwell, Heather, Hurlow, Claire, Moore, Laurence, Segrott, Jeremy, Gillespie, David, Lau, Mandy, Holliday, Jo, Murphy, Simon, Foxcroft, David, Hood, Kerenza, Scourfield, Jonathan, Phillips, Ceri, Roberts, Zoe, Rothwell, Heather, Hurlow, Claire, and Moore, Laurence

Abstract

Objectives. The Strengthening Families Programme 10–14 (SFP10-14) is a USA-developed universal group-based intervention aiming to prevent substance misuse by strengthening protective factors within the family. This study evaluated a proportionate universal implementation of the adapted UK version (SFP10-14UK) which brought together families identified as likely/not likely to experience/present challenges within a group setting. Design. Pragmatic cluster-randomised controlled effectiveness trial, with families as the unit of randomisation and embedded process and economic evaluations. Setting. The study took place in seven counties of Wales, UK. Participants. 715 families (919 parents/carers, 931 young people) were randomised. Interventions. Families randomised to the intervention arm received the SFP10-14 comprising seven weekly sessions. Families in intervention and control arms received existing services as normal. Outcome measures. Primary outcomes were the number of occasions young people reported drinking alcohol in the last 30 days; and drunkenness during the same period, dichotomised as ‘never’ and ‘1–2 times or more’. Secondary outcomes examined alcohol/tobacco/substance behaviours including: cannabis use; weekly smoking (validated by salivary cotinine measures); age of alcohol initiation; frequency of drinking >5 drinks in a row; frequency of different types of alcoholic drinks; alcohol-related problems. Retention: primary analysis included 746 young people (80.1%) (alcohol consumption) and 732 young people (78.6%) (drunkenness). Results. There was no evidence of statistically significant between-group differences 2 years after randomisation for primary outcomes (young people’s alcohol consumption in the last 30 days adjusted OR=1.11, 95% CI 0.72 to 1.71, p=0.646; drunkenness in the last 30 days adjusted OR=1.46, 95% CI 0.83 to 2.55, p=0.185). There were no statistically significant between-group differences for other substance use outcomes, or those relati

Published
2022

5. Associations with Post-Consultation Health-Status in Primary Care Managed Acute Exacerbation of COPD

Author

Gillespie,David, Francis,Nick, Ahmed,Haroon, Hood,Kerenza, Llor,Carl, White,Patrick, Thomas-Jones,Emma, Stanton,Helen, Sewell,Bernadette, Phillips,Rhiannon, Naik,Gurudutt, Melbye,Hasse, Lowe,Rachel, Kirby,Nigel, Cochrane,Ann, Bates,Janine, Alam,Mohammed Fasihul, Butler,Christopher, Gillespie,David, Francis,Nick, Ahmed,Haroon, Hood,Kerenza, Llor,Carl, White,Patrick, Thomas-Jones,Emma, Stanton,Helen, Sewell,Bernadette, Phillips,Rhiannon, Naik,Gurudutt, Melbye,Hasse, Lowe,Rachel, Kirby,Nigel, Cochrane,Ann, Bates,Janine, Alam,Mohammed Fasihul, and Butler,Christopher

Abstract

David Gillespie,1,2 Nick Francis,3 Haroon Ahmed,4 Kerenza Hood,2 Carl Llor,5 Patrick White,6 Emma Thomas-Jones,2 Helen Stanton,2 Bernadette Sewell,7 Rhiannon Phillips,8 Gurudutt Naik,4 Hasse Melbye,9 Rachel Lowe,2 Nigel Kirby,2 Ann Cochrane,10 Janine Bates,2 Mohammed Fasihul Alam,11 Christopher Butler1 1Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, England, UK; 2Centre for Trials Research, School of Medicine, College of Biomedical & Life Sciences, Cardiff University, Cardiff, Wales, UK; 3Primary Care, Population Sciences and Medical Education, University of Southampton, Southampton, England, UK; 4Division of Population Medicine, School of Medicine, Cardiff University, Cardiff, Wales, UK; 5University Institute in Primary Care Research Jordi Gol, Via Roma Health Centre, Barcelona, Spain; 6School of Population Health and Environmental Sciences, Kings College London, London, England, UK; 7Swansea Centre for Health Economics, Swansea University, Swansea, Wales, UK; 8Cardiff School of Sport & Health Science, Cardiff Metropolitan University, Cardiff, Wales, UK; 9General Practice Research Unit, Department of Community Medicine, UIT the Arctic University of Norway, Tromsø, Norway; 10York Trials Unit, Department of Health Sciences, University of York, York, England, UK; 11Department of Public Health, College of Health Sciences, QU-Health, Qatar University, Doha, QatarCorrespondence: David Gillespie, Nuffield Department of Primary Care Health Sciences, University of Oxford, Radcliffe Observatory Quarter, Woodstock Road, Oxford, England, OX2 6GG, UK, Email david.gillespie@phc.ox.ac.ukBackground: It has been demonstrated that antibiotic prescribing for Acute Exacerbations of Chronic Obstructive Pulmonary Disease (AECOPD) can be safely reduced in primary care when general practitioners have access to C-reactive protein (CRP) rapid testing.Aim: To investigate the factors associated with post-consultation COPD health status in patients

Published
2022

9. Associations with antibiotic prescribing for acute exacerbation of COPD in primary care:secondary analysis of a randomised controlled trial

Author

Gillespie, David, Butler, Christopher C., Bates, Janine, Hood, Kerenza, Melbye, Hasse, Phillips, Rhiannon, Stanton, Helen, Alam, Mohammed Fasihul, Cals, Jochen Wl, Cochrane, Ann, Kirby, Nigel, Llor, Carl, Lowe, Rachel, Naik, Gurudutt, Riga, Evgenia, Sewell, Bernadette, Thomas-Jones, Emma, White, Patrick, Francis, Nick A., Gillespie, David, Butler, Christopher C., Bates, Janine, Hood, Kerenza, Melbye, Hasse, Phillips, Rhiannon, Stanton, Helen, Alam, Mohammed Fasihul, Cals, Jochen Wl, Cochrane, Ann, Kirby, Nigel, Llor, Carl, Lowe, Rachel, Naik, Gurudutt, Riga, Evgenia, Sewell, Bernadette, Thomas-Jones, Emma, White, Patrick, and Francis, Nick A.

Abstract

BACKGROUND: C-reactive protein (CRP) point-of-care testing can reduce antibiotic use in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) in primary care, without compromising patient care. Further safe reductions may be possible. AIM: To investigate the associations between presenting features and antibiotic prescribing in patients with AECOPD in primary care. DESIGN AND SETTING: Secondary analysis of a randomised controlled trial of participants presenting with AECOPD in primary care (the PACE trial). METHOD: Clinicians collected participants' demographic features, comorbid illnesses, clinical signs, and symptoms. Antibiotic prescribing decisions were made after participants were randomised to receive a point-of-care CRP measurement or usual care. Multivariable regression models were fitted to explore the association between patient and clinical features and antibiotic prescribing, and extended to further explore any interactions with CRP measurement category (CRP not measured, CRP <20 mg/l, or CRP ≥20 mg/l). RESULTS: A total of 649 participants from 86 general practices across England and Wales were included. Odds of antibiotic prescribing were higher in the presence of clinician-recorded crackles (adjusted odds ratio [AOR] = 5.22, 95% confidence interval [CI] = 3.24 to 8.41), wheeze (AOR = 1.64, 95% CI = 1.07 to 2.52), diminished vesicular breathing (AOR = 2.95, 95% CI = 1.70 to 5.10), or clinician-reported evidence of consolidation (AOR = 34.40, 95% CI = 2.84 to 417.27). Increased age was associated with lower odds of antibiotic prescribing (AOR per additional year increase = 0.98, 95% CI = 0.95 to 1.00), as was the presence of heart failure (AOR = 0.32, 95% CI = 0.12 to 0.85). CONCLUSION: Several demographic features and clinical signs and symptoms are associated with antibiotic prescribing in AECOPD. Diagnostic and prognostic value of these features may help identify further safe reductions.

Published
2021

10. Associations with antibiotic prescribing for acute exacerbation of COPD in primary care:secondary analysis of a randomised controlled trial

Author

Gillespie, David, Butler, Christopher C., Bates, Janine, Hood, Kerenza, Melbye, Hasse, Phillips, Rhiannon, Stanton, Helen, Alam, Mohammed Fasihul, Cals, Jochen Wl, Cochrane, Ann, Kirby, Nigel, Llor, Carl, Lowe, Rachel, Naik, Gurudutt, Riga, Evgenia, Sewell, Bernadette, Thomas-Jones, Emma, White, Patrick, Francis, Nick A., Gillespie, David, Butler, Christopher C., Bates, Janine, Hood, Kerenza, Melbye, Hasse, Phillips, Rhiannon, Stanton, Helen, Alam, Mohammed Fasihul, Cals, Jochen Wl, Cochrane, Ann, Kirby, Nigel, Llor, Carl, Lowe, Rachel, Naik, Gurudutt, Riga, Evgenia, Sewell, Bernadette, Thomas-Jones, Emma, White, Patrick, and Francis, Nick A.

Abstract

BACKGROUND: C-reactive protein (CRP) point-of-care testing can reduce antibiotic use in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) in primary care, without compromising patient care. Further safe reductions may be possible. AIM: To investigate the associations between presenting features and antibiotic prescribing in patients with AECOPD in primary care. DESIGN AND SETTING: Secondary analysis of a randomised controlled trial of participants presenting with AECOPD in primary care (the PACE trial). METHOD: Clinicians collected participants' demographic features, comorbid illnesses, clinical signs, and symptoms. Antibiotic prescribing decisions were made after participants were randomised to receive a point-of-care CRP measurement or usual care. Multivariable regression models were fitted to explore the association between patient and clinical features and antibiotic prescribing, and extended to further explore any interactions with CRP measurement category (CRP not measured, CRP <20 mg/l, or CRP ≥20 mg/l). RESULTS: A total of 649 participants from 86 general practices across England and Wales were included. Odds of antibiotic prescribing were higher in the presence of clinician-recorded crackles (adjusted odds ratio [AOR] = 5.22, 95% confidence interval [CI] = 3.24 to 8.41), wheeze (AOR = 1.64, 95% CI = 1.07 to 2.52), diminished vesicular breathing (AOR = 2.95, 95% CI = 1.70 to 5.10), or clinician-reported evidence of consolidation (AOR = 34.40, 95% CI = 2.84 to 417.27). Increased age was associated with lower odds of antibiotic prescribing (AOR per additional year increase = 0.98, 95% CI = 0.95 to 1.00), as was the presence of heart failure (AOR = 0.32, 95% CI = 0.12 to 0.85). CONCLUSION: Several demographic features and clinical signs and symptoms are associated with antibiotic prescribing in AECOPD. Diagnostic and prognostic value of these features may help identify further safe reductions.

Published
2021

11. Clinical Features and C-Reactive Protein as Predictors of Bacterial Exacerbations of COPD

Author

Francis,Nick A, Gillespie,David, Wootton,Mandy, White,Patrick, Bates,Janine, Richards,Jennifer, Melbye,Hasse, Hood,Kerenza, Butler,Christopher C, Francis,Nick A, Gillespie,David, Wootton,Mandy, White,Patrick, Bates,Janine, Richards,Jennifer, Melbye,Hasse, Hood,Kerenza, and Butler,Christopher C

Abstract

Nick A Francis,1 David Gillespie,2 Mandy Wootton,3 Patrick White,4 Janine Bates,2 Jennifer Richards,3 Hasse Melbye,5 Kerenza Hood,2 Christopher C Butler6 1Primary Care, Population Sciences and Medical Education, University of Southampton, Southampton, England, UK; 2Centre for Trials Research, Cardiff University, Cardiff, Wales, UK; 3Specialist Antimicrobial Chemotherapy Unit, Microbiology Cardiff, Public Health Wales, Cardiff, Wales, UK; 4School of Population Health and Environmental Sciences, King’s College London, London, England, UK; 5Department of Community Medicine, UIT the Arctic University of Norway, Tromsø, Norway; 6Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, England, UKCorrespondence: Nick A FrancisPrimary Care, Population Sciences and Medical Education, University of Southampton, Aldermoor Health Centre, Southampton SO16 5ST, UKEmail nick.francis@soton.ac.ukIntroduction: Identifying predictors of bacterial and viral pathogens in sputum from patients with acute exacerbations of chronic obstructive pulmonary disease (COPD) may help direct management.Methods: We used data from a trial evaluating a C-reactive protein (CRP) point of care guided approach to managing COPD exacerbations in primary care. We used regression analyses to identify baseline clinical features, including CRP value in those randomized to testing, associated with bacterial, viral or mixed infections, defined by the presence of bacterial and viral pathogens in sputum, detected by culture or polymerase chain reaction (PCR), respectively.Results: Of 386 participants with baseline sputum samples, 79 (20.5%), 123 (31.9%), and 91 (23.6%) had bacterial, viral/atypical, and mixed bacterial/viral/atypical pathogens identified, respectively. Increasing sputum purulence assessed by color chart was associated with increased odds of finding bacterial and mixed (bacterial and viral/atypical) pathogens in sputum (area under the ROC curve (AUROC)

Published
2020

12. Challenges in managing urinary tract infection and the potential of a point-of-care test guided care in primary care : an international qualitative study

Author

Brookes-Howell, Lucy, Thomas-Jones, Emma, Bates, Janine, Bekkers, Marie-Jet, Brugman, Curt, Coulman, Elinor, Francis, Nick, Hashmi, Khurram, Hood, Kerenza, Kirby, Nigel, Llor, Carl, Little, Paul, Moore, Michael, Moragas, Anna, Rumsby, Kate, Verheij, Theo, Butler, Christopher, Brookes-Howell, Lucy, Thomas-Jones, Emma, Bates, Janine, Bekkers, Marie-Jet, Brugman, Curt, Coulman, Elinor, Francis, Nick, Hashmi, Khurram, Hood, Kerenza, Kirby, Nigel, Llor, Carl, Little, Paul, Moore, Michael, Moragas, Anna, Rumsby, Kate, Verheij, Theo, and Butler, Christopher

Published
2019

13. Challenges in managing urinary tract infection and the potential of a point-of-care test guided care in primary care : an international qualitative study

Author

Brookes-Howell, Lucy, Thomas-Jones, Emma, Bates, Janine, Bekkers, Marie-Jet, Brugman, Curt, Coulman, Elinor, Francis, Nick, Hashmi, Khurram, Hood, Kerenza, Kirby, Nigel, Llor, Carl, Little, Paul, Moore, Michael, Moragas, Anna, Rumsby, Kate, Verheij, Theo, Butler, Christopher, Brookes-Howell, Lucy, Thomas-Jones, Emma, Bates, Janine, Bekkers, Marie-Jet, Brugman, Curt, Coulman, Elinor, Francis, Nick, Hashmi, Khurram, Hood, Kerenza, Kirby, Nigel, Llor, Carl, Little, Paul, Moore, Michael, Moragas, Anna, Rumsby, Kate, Verheij, Theo, and Butler, Christopher

Published
2019

14. Challenges in managing urinary tract infection and the potential of a point-of-care test guided care in primary care : an international qualitative study

Author

Brookes-Howell, Lucy, Thomas-Jones, Emma, Bates, Janine, Bekkers, Marie-Jet, Brugman, Curt, Coulman, Elinor, Francis, Nick, Hashmi, Khurram, Hood, Kerenza, Kirby, Nigel, Llor, Carl, Little, Paul, Moore, Michael, Moragas, Anna, Rumsby, Kate, Verheij, Theo, Butler, Christopher, Brookes-Howell, Lucy, Thomas-Jones, Emma, Bates, Janine, Bekkers, Marie-Jet, Brugman, Curt, Coulman, Elinor, Francis, Nick, Hashmi, Khurram, Hood, Kerenza, Kirby, Nigel, Llor, Carl, Little, Paul, Moore, Michael, Moragas, Anna, Rumsby, Kate, Verheij, Theo, and Butler, Christopher

Published
2019

15. Challenges in managing urinary tract infection and the potential of a point-of-care test guided care in primary care: an international qualitative study

Author

HAG Infectieziekten, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Brookes-Howell, Lucy, Thomas-Jones, Emma, Bates, Janine, Bekkers, Marie-Jet, Brugman, Curt, Coulman, Elinor, Francis, Nick, Hashmi, Khurram, Hood, Kerenza, Kirby, Nigel, Llor, Carl, Little, Paul, Moore, Michael, Moragas, Anna, Rumsby, Kate, Verheij, Theo, Butler, Christopher, HAG Infectieziekten, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Brookes-Howell, Lucy, Thomas-Jones, Emma, Bates, Janine, Bekkers, Marie-Jet, Brugman, Curt, Coulman, Elinor, Francis, Nick, Hashmi, Khurram, Hood, Kerenza, Kirby, Nigel, Llor, Carl, Little, Paul, Moore, Michael, Moragas, Anna, Rumsby, Kate, Verheij, Theo, and Butler, Christopher

Published
2019

16. Point-of-care urine culture for managing urinary tract infection in primary care : A randomised controlled trial of clinical and cost-effectiveness

Author

Butler, Christopher C., Francis, Nick A., Thomas-Jones, Emma, Longo, Mirella, Wootton, Mandy, Llor, Carl, Little, Paul, Moore, Michael, Bates, Janine, Pickles, Timothy, Kirby, Nigel, Gillespie, David, Rumsby, Kate, Brugman, Curt, Gal, Micaela, Hood, Kerenza, Verheij, Theo, Butler, Christopher C., Francis, Nick A., Thomas-Jones, Emma, Longo, Mirella, Wootton, Mandy, Llor, Carl, Little, Paul, Moore, Michael, Bates, Janine, Pickles, Timothy, Kirby, Nigel, Gillespie, David, Rumsby, Kate, Brugman, Curt, Gal, Micaela, Hood, Kerenza, and Verheij, Theo

Published
2018

17. Point-of-care urine culture for managing urinary tract infection in primary care : A randomised controlled trial of clinical and cost-effectiveness

Author

Butler, Christopher C., Francis, Nick A., Thomas-Jones, Emma, Longo, Mirella, Wootton, Mandy, Llor, Carl, Little, Paul, Moore, Michael, Bates, Janine, Pickles, Timothy, Kirby, Nigel, Gillespie, David, Rumsby, Kate, Brugman, Curt, Gal, Micaela, Hood, Kerenza, Verheij, Theo, Butler, Christopher C., Francis, Nick A., Thomas-Jones, Emma, Longo, Mirella, Wootton, Mandy, Llor, Carl, Little, Paul, Moore, Michael, Bates, Janine, Pickles, Timothy, Kirby, Nigel, Gillespie, David, Rumsby, Kate, Brugman, Curt, Gal, Micaela, Hood, Kerenza, and Verheij, Theo

Published
2018

18. Point-of-care urine culture for managing urinary tract infection in primary care : A randomised controlled trial of clinical and cost-effectiveness

Author

Butler, Christopher C., Francis, Nick A., Thomas-Jones, Emma, Longo, Mirella, Wootton, Mandy, Llor, Carl, Little, Paul, Moore, Michael, Bates, Janine, Pickles, Timothy, Kirby, Nigel, Gillespie, David, Rumsby, Kate, Brugman, Curt, Gal, Micaela, Hood, Kerenza, Verheij, Theo, Butler, Christopher C., Francis, Nick A., Thomas-Jones, Emma, Longo, Mirella, Wootton, Mandy, Llor, Carl, Little, Paul, Moore, Michael, Bates, Janine, Pickles, Timothy, Kirby, Nigel, Gillespie, David, Rumsby, Kate, Brugman, Curt, Gal, Micaela, Hood, Kerenza, and Verheij, Theo

Published
2018

19. Point-of-care urine culture for managing urinary tract infection in primary care: A randomised controlled trial of clinical and cost-effectiveness

Author

HAG Infectieziekten, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Butler, Christopher C., Francis, Nick A., Thomas-Jones, Emma, Longo, Mirella, Wootton, Mandy, Llor, Carl, Little, Paul, Moore, Michael, Bates, Janine, Pickles, Timothy, Kirby, Nigel, Gillespie, David, Rumsby, Kate, Brugman, Curt, Gal, Micaela, Hood, Kerenza, Verheij, Theo, HAG Infectieziekten, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Butler, Christopher C., Francis, Nick A., Thomas-Jones, Emma, Longo, Mirella, Wootton, Mandy, Llor, Carl, Little, Paul, Moore, Michael, Bates, Janine, Pickles, Timothy, Kirby, Nigel, Gillespie, David, Rumsby, Kate, Brugman, Curt, Gal, Micaela, Hood, Kerenza, and Verheij, Theo

Published
2018

20. Determinants of initiation, implementation, and discontinuation of amoxicillin by adults with acute cough in primary care

Author

Gillespie, David, Farewell, Daniel, Brookes-Howell, Lucy, Butler, Christopher C., Coenen, Samuel, Francis, Nick A., Little, Paul, Stuart, Beth, Verheij, Theo, Hood, Kerenza, Grace consortium, Gillespie, David, Farewell, Daniel, Brookes-Howell, Lucy, Butler, Christopher C., Coenen, Samuel, Francis, Nick A., Little, Paul, Stuart, Beth, Verheij, Theo, Hood, Kerenza, and Grace consortium

Published
2017

22. Variations in presentation, management, and patient outcomes of urinary tract infection : a prospective four-country primary care observational cohort study

Author

Butler, Christopher C., Francis, Nick A., Thomas-Jones, Emma, Llor, Carl, Bongard, Emily, Moore, Michael, Little, Paul, Bates, Janine, Lau, Mandy, Pickles, Timothy, Gal, Micaela, Wootton, Mandy, Kirby, Nigel, Gillespie, David, Rumbsy, Kate, Brugman, Curt, Hood, Kerenza, Verheij, Theo, Butler, Christopher C., Francis, Nick A., Thomas-Jones, Emma, Llor, Carl, Bongard, Emily, Moore, Michael, Little, Paul, Bates, Janine, Lau, Mandy, Pickles, Timothy, Gal, Micaela, Wootton, Mandy, Kirby, Nigel, Gillespie, David, Rumbsy, Kate, Brugman, Curt, Hood, Kerenza, and Verheij, Theo

Published
2017

23. Clinicians' interpretations of point of care urine culture versus laboratory culture results : Analysis from the four-country POETIC trial of diagnosis of uncomplicated urinary tract infection in primary care

Author

Hullegie, Saskia, Wootton, Mandy, Verheij, Theo J.M., Thomas-Jones, Emma, Bates, Janine, Hood, Kerenza, Gal, Micaela, Francis, Nick A., Little, Paul, Moore, Michael, Llor, Carl, Pickles, Timothy, Gillespie, David, Kirby, Nigel, Brugman, Curt, Butler, Christopher C., Hullegie, Saskia, Wootton, Mandy, Verheij, Theo J.M., Thomas-Jones, Emma, Bates, Janine, Hood, Kerenza, Gal, Micaela, Francis, Nick A., Little, Paul, Moore, Michael, Llor, Carl, Pickles, Timothy, Gillespie, David, Kirby, Nigel, Brugman, Curt, and Butler, Christopher C.

Published
2017

24. Clinicians' interpretations of point of care urine culture versus laboratory culture results : Analysis from the four-country POETIC trial of diagnosis of uncomplicated urinary tract infection in primary care

Author

Hullegie, Saskia, Wootton, Mandy, Verheij, Theo J.M., Thomas-Jones, Emma, Bates, Janine, Hood, Kerenza, Gal, Micaela, Francis, Nick A., Little, Paul, Moore, Michael, Llor, Carl, Pickles, Timothy, Gillespie, David, Kirby, Nigel, Brugman, Curt, Butler, Christopher C., Hullegie, Saskia, Wootton, Mandy, Verheij, Theo J.M., Thomas-Jones, Emma, Bates, Janine, Hood, Kerenza, Gal, Micaela, Francis, Nick A., Little, Paul, Moore, Michael, Llor, Carl, Pickles, Timothy, Gillespie, David, Kirby, Nigel, Brugman, Curt, and Butler, Christopher C.

Published
2017

26. Determinants of initiation, implementation, and discontinuation of amoxicillin by adults with acute cough in primary care

Author

Gillespie, David, Farewell, Daniel, Brookes-Howell, Lucy, Butler, Christopher C., Coenen, Samuel, Francis, Nick A., Little, Paul, Stuart, Beth, Verheij, Theo, Hood, Kerenza, Grace consortium, Gillespie, David, Farewell, Daniel, Brookes-Howell, Lucy, Butler, Christopher C., Coenen, Samuel, Francis, Nick A., Little, Paul, Stuart, Beth, Verheij, Theo, Hood, Kerenza, and Grace consortium

Published
2017

27. Variations in presentation, management, and patient outcomes of urinary tract infection : a prospective four-country primary care observational cohort study

Author

Butler, Christopher C., Francis, Nick A., Thomas-Jones, Emma, Llor, Carl, Bongard, Emily, Moore, Michael, Little, Paul, Bates, Janine, Lau, Mandy, Pickles, Timothy, Gal, Micaela, Wootton, Mandy, Kirby, Nigel, Gillespie, David, Rumbsy, Kate, Brugman, Curt, Hood, Kerenza, Verheij, Theo, Butler, Christopher C., Francis, Nick A., Thomas-Jones, Emma, Llor, Carl, Bongard, Emily, Moore, Michael, Little, Paul, Bates, Janine, Lau, Mandy, Pickles, Timothy, Gal, Micaela, Wootton, Mandy, Kirby, Nigel, Gillespie, David, Rumbsy, Kate, Brugman, Curt, Hood, Kerenza, and Verheij, Theo

Published
2017

28. Determinants of initiation, implementation, and discontinuation of amoxicillin by adults with acute cough in primary care

Author

Gillespie, David, Farewell, Daniel, Brookes-Howell, Lucy, Butler, Christopher C., Coenen, Samuel, Francis, Nick A., Little, Paul, Stuart, Beth, Verheij, Theo, Hood, Kerenza, Grace consortium, Gillespie, David, Farewell, Daniel, Brookes-Howell, Lucy, Butler, Christopher C., Coenen, Samuel, Francis, Nick A., Little, Paul, Stuart, Beth, Verheij, Theo, Hood, Kerenza, and Grace consortium

Published
2017

29. Clinicians' interpretations of point of care urine culture versus laboratory culture results : Analysis from the four-country POETIC trial of diagnosis of uncomplicated urinary tract infection in primary care

Author

Hullegie, Saskia, Wootton, Mandy, Verheij, Theo J.M., Thomas-Jones, Emma, Bates, Janine, Hood, Kerenza, Gal, Micaela, Francis, Nick A., Little, Paul, Moore, Michael, Llor, Carl, Pickles, Timothy, Gillespie, David, Kirby, Nigel, Brugman, Curt, Butler, Christopher C., Hullegie, Saskia, Wootton, Mandy, Verheij, Theo J.M., Thomas-Jones, Emma, Bates, Janine, Hood, Kerenza, Gal, Micaela, Francis, Nick A., Little, Paul, Moore, Michael, Llor, Carl, Pickles, Timothy, Gillespie, David, Kirby, Nigel, Brugman, Curt, and Butler, Christopher C.

Published
2017

30. Variations in presentation, management, and patient outcomes of urinary tract infection : a prospective four-country primary care observational cohort study

Author

Butler, Christopher C., Francis, Nick A., Thomas-Jones, Emma, Llor, Carl, Bongard, Emily, Moore, Michael, Little, Paul, Bates, Janine, Lau, Mandy, Pickles, Timothy, Gal, Micaela, Wootton, Mandy, Kirby, Nigel, Gillespie, David, Rumbsy, Kate, Brugman, Curt, Hood, Kerenza, Verheij, Theo, Butler, Christopher C., Francis, Nick A., Thomas-Jones, Emma, Llor, Carl, Bongard, Emily, Moore, Michael, Little, Paul, Bates, Janine, Lau, Mandy, Pickles, Timothy, Gal, Micaela, Wootton, Mandy, Kirby, Nigel, Gillespie, David, Rumbsy, Kate, Brugman, Curt, Hood, Kerenza, and Verheij, Theo

Published
2017

32. Determinants of initiation, implementation, and discontinuation of amoxicillin by adults with acute cough in primary care

Author

Gillespie,David, Farewell,Daniel, Brookes-Howell,Lucy, Butler,Christopher, Coenen,Samuel, Francis,Nick, Little,Paul, Stuart,Beth, Verheij,Theo, Hood,Kerenza, Gillespie,David, Farewell,Daniel, Brookes-Howell,Lucy, Butler,Christopher, Coenen,Samuel, Francis,Nick, Little,Paul, Stuart,Beth, Verheij,Theo, and Hood,Kerenza

Abstract

David Gillespie,1 Daniel Farewell,2 Lucy Brookes-Howell,1 Christopher C Butler,3 Samuel Coenen,4–6 Nick A Francis,2 Paul Little,7 Beth Stuart,7 Theo Verheij,8 Kerenza Hood1 On behalf of the GRACE consortium 1Centre for Trials Research, College of Biomedical & Life Sciences, 2Division of Population Medicine, School of Medicine, Cardiff University, Cardiff, 3Nuffield Department of Primary Health Care Sciences, University of Oxford, Oxford, UK; 4Laboratory of Medical Microbiology, Vaccine & Infectious Disease Institute (VAXINFECTIO), 5Centre for General Practice, Department of Primary and Interdisciplinary Care (ELIZA), 6Clinical Epidemiology and Medical Statistics, Department of Epidemiology and Social Medicine (ESOC), University of Antwerp, Antwerp, Belgium; 7Aldermoor Health Centre, Primary Care and Population Sciences, Faculty of Medicine, University of Southampton, Southampton, UK; 8Department of General Practice, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands Aim: To investigate the determinants of adherence to amoxicillin in patients with acute lower respiratory tract infection.Materials and methods: Three European data sets were used. Adherence data were collected using self-reported diaries. Candidate determinants included factors relating to patient, condition, therapy, health care system/provider, and the study in which the patient participated. Logistic and Cox regression models were used to investigate the determinants of initiation, implementation, and discontinuation of amoxicillin.Results: Although initiation differed across samples, implementation and discontinuation were similar. Determinants of initiation were days waited before consulting, duration of prescription, and being in a country where a doctor-issued sick certificate is required for being off work for <7 days. Implementation was higher for older participants or those with abnormal auscultation.

Published
2017

33. Clinicians' interpretations of point of care urine culture versus laboratory culture results: Analysis from the four-country POETIC trial of diagnosis of uncomplicated urinary tract infection in primary care

Author

HAG Infectieziekten, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Hullegie, Saskia, Wootton, Mandy, Verheij, Theo J.M., Thomas-Jones, Emma, Bates, Janine, Hood, Kerenza, Gal, Micaela, Francis, Nick A., Little, Paul, Moore, Michael, Llor, Carl, Pickles, Timothy, Gillespie, David, Kirby, Nigel, Brugman, Curt, Butler, Christopher C., HAG Infectieziekten, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Hullegie, Saskia, Wootton, Mandy, Verheij, Theo J.M., Thomas-Jones, Emma, Bates, Janine, Hood, Kerenza, Gal, Micaela, Francis, Nick A., Little, Paul, Moore, Michael, Llor, Carl, Pickles, Timothy, Gillespie, David, Kirby, Nigel, Brugman, Curt, and Butler, Christopher C.

Published
2017

34. Determinants of initiation, implementation, and discontinuation of amoxicillin by adults with acute cough in primary care

Author

Huisartsopleiding Opleiders, UMC Utrecht, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Gillespie, David, Farewell, Daniel, Brookes-Howell, Lucy, Butler, Christopher C., Coenen, Samuel, Francis, Nick A., Little, Paul, Stuart, Beth, Verheij, Theo, Hood, Kerenza, GRACE Consortium, Huisartsopleiding Opleiders, UMC Utrecht, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Gillespie, David, Farewell, Daniel, Brookes-Howell, Lucy, Butler, Christopher C., Coenen, Samuel, Francis, Nick A., Little, Paul, Stuart, Beth, Verheij, Theo, Hood, Kerenza, and GRACE Consortium

Published
2017

35. Variations in presentation, management, and patient outcomes of urinary tract infection: a prospective four-country primary care observational cohort study

Author

HAG Infectieziekten, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Butler, Christopher C., Francis, Nick A., Thomas-Jones, Emma, Llor, Carl, Bongard, Emily, Moore, Michael, Little, Paul, Bates, Janine, Lau, Mandy, Pickles, Timothy, Gal, Micaela, Wootton, Mandy, Kirby, Nigel, Gillespie, David, Rumbsy, Kate, Brugman, Curt, Hood, Kerenza, Verheij, Theo, HAG Infectieziekten, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Butler, Christopher C., Francis, Nick A., Thomas-Jones, Emma, Llor, Carl, Bongard, Emily, Moore, Michael, Little, Paul, Bates, Janine, Lau, Mandy, Pickles, Timothy, Gal, Micaela, Wootton, Mandy, Kirby, Nigel, Gillespie, David, Rumbsy, Kate, Brugman, Curt, Hood, Kerenza, and Verheij, Theo

Published
2017

36. Comparison between treatment effects in a randomised controlled trial and an observational study using propensity scores in primary care

Author

HAG Infectieziekten, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Stuart, Beth L., Grebel, Louise E.N., Butler, Christopher C., Hood, Kerenza, Verheij, Theo J.M., Little, Paul, HAG Infectieziekten, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Stuart, Beth L., Grebel, Louise E.N., Butler, Christopher C., Hood, Kerenza, Verheij, Theo J.M., and Little, Paul

Published
2017

37. Discrepancies between qualitative and quantitative evaluation of randomised controlled trial results : achieving clarity through mixed methods triangulation

Author

Tonkin-Crine, Sarah, Anthierens, Sibyl, Hood, Kerenza, Yardley, Lucy, Cals, Jochen W L, Francis, Nick A, Coenen, Samuel, van der Velden, Alike W, Godycki-Cwirko, Maciek, Llor, Carl, Butler, Chris C, Verheij, Theo J M, Goossens, Herman, Little, Paul, GRACE INTRO/CHAMP consortium, Tonkin-Crine, Sarah, Anthierens, Sibyl, Hood, Kerenza, Yardley, Lucy, Cals, Jochen W L, Francis, Nick A, Coenen, Samuel, van der Velden, Alike W, Godycki-Cwirko, Maciek, Llor, Carl, Butler, Chris C, Verheij, Theo J M, Goossens, Herman, Little, Paul, and GRACE INTRO/CHAMP consortium

Published
2016

39. Amoxicillin for clinically unsuspected pneumonia in primary care : subgroup analysis

Author

Little, Paul, Elshof, Nori, Broekhuizen, Berna D. L., Moore, Michael, Stuart, Beth, Butler, Chris C., Hood, Kerenza, Ieven, Margareta, Coenen, Samuel, Goossens, Herman, Verheij, Theo J. M., GRACE Consortium, Teepe, J, Little, Paul, Elshof, Nori, Broekhuizen, Berna D. L., Moore, Michael, Stuart, Beth, Butler, Chris C., Hood, Kerenza, Ieven, Margareta, Coenen, Samuel, Goossens, Herman, Verheij, Theo J. M., GRACE Consortium, and Teepe, J

Published
2016

40. Discrepancies between qualitative and quantitative evaluation of randomised controlled trial results : achieving clarity through mixed methods triangulation

Author

Tonkin-Crine, Sarah, Anthierens, Sibyl, Hood, Kerenza, Yardley, Lucy, Cals, Jochen W L, Francis, Nick A, Coenen, Samuel, van der Velden, Alike W, Godycki-Cwirko, Maciek, Llor, Carl, Butler, Chris C, Verheij, Theo J M, Goossens, Herman, Little, Paul, GRACE INTRO/CHAMP consortium, Tonkin-Crine, Sarah, Anthierens, Sibyl, Hood, Kerenza, Yardley, Lucy, Cals, Jochen W L, Francis, Nick A, Coenen, Samuel, van der Velden, Alike W, Godycki-Cwirko, Maciek, Llor, Carl, Butler, Chris C, Verheij, Theo J M, Goossens, Herman, Little, Paul, and GRACE INTRO/CHAMP consortium

Published
2016

42. Amoxicillin for clinically unsuspected pneumonia in primary care : subgroup analysis

Author

Little, Paul, Elshof, Nori, Broekhuizen, Berna D. L., Moore, Michael, Stuart, Beth, Butler, Chris C., Hood, Kerenza, Ieven, Margareta, Coenen, Samuel, Goossens, Herman, Verheij, Theo J. M., GRACE Consortium, Teepe, J, Little, Paul, Elshof, Nori, Broekhuizen, Berna D. L., Moore, Michael, Stuart, Beth, Butler, Chris C., Hood, Kerenza, Ieven, Margareta, Coenen, Samuel, Goossens, Herman, Verheij, Theo J. M., GRACE Consortium, and Teepe, J

Published
2016

43. Discrepancies between qualitative and quantitative evaluation of randomised controlled trial results : achieving clarity through mixed methods triangulation

Author

Tonkin-Crine, Sarah, Anthierens, Sibyl, Hood, Kerenza, Yardley, Lucy, Cals, Jochen W L, Francis, Nick A, Coenen, Samuel, van der Velden, Alike W, Godycki-Cwirko, Maciek, Llor, Carl, Butler, Chris C, Verheij, Theo J M, Goossens, Herman, Little, Paul, GRACE INTRO/CHAMP consortium, Tonkin-Crine, Sarah, Anthierens, Sibyl, Hood, Kerenza, Yardley, Lucy, Cals, Jochen W L, Francis, Nick A, Coenen, Samuel, van der Velden, Alike W, Godycki-Cwirko, Maciek, Llor, Carl, Butler, Chris C, Verheij, Theo J M, Goossens, Herman, Little, Paul, and GRACE INTRO/CHAMP consortium

Published
2016

44. Amoxicillin for clinically unsuspected pneumonia in primary care : subgroup analysis

Author

Little, Paul, Elshof, Nori, Broekhuizen, Berna D. L., Moore, Michael, Stuart, Beth, Butler, Chris C., Hood, Kerenza, Ieven, Margareta, Coenen, Samuel, Goossens, Herman, Verheij, Theo J. M., GRACE Consortium, Teepe, J, Little, Paul, Elshof, Nori, Broekhuizen, Berna D. L., Moore, Michael, Stuart, Beth, Butler, Chris C., Hood, Kerenza, Ieven, Margareta, Coenen, Samuel, Goossens, Herman, Verheij, Theo J. M., GRACE Consortium, and Teepe, J

Published
2016

46. Family practitioners' advice about taking time off work for lower respiratory tract infections: A prospective study in twelve European primary care networks

Author

UMC Utrecht, HAG Infectieziekten, JC onderzoeksprogramma Infectieziekten, Infection & Immunity, Godycki-Cwirko, MacIek, Nocun, Marek, Butler, Christopher C., Little, Paul, Verheij, Theo, Hood, Kerenza, Fleten, Nils, Kowalczyk, Anna, Melbye, Hasse, UMC Utrecht, HAG Infectieziekten, JC onderzoeksprogramma Infectieziekten, Infection & Immunity, Godycki-Cwirko, MacIek, Nocun, Marek, Butler, Christopher C., Little, Paul, Verheij, Theo, Hood, Kerenza, Fleten, Nils, Kowalczyk, Anna, and Melbye, Hasse

Published
2016

47. Amoxicillin for clinically unsuspected pneumonia in primary care: subgroup analysis

Author

HAG Infectieziekten, JC onderzoeksprogramma Infectieziekten, Infection & Immunity, Little, Paul, Elshof, Nori, Broekhuizen, Berna D. L., Moore, Michael, Stuart, Beth, Butler, Chris C., Hood, Kerenza, Ieven, Margareta, Coenen, Samuel, Goossens, Herman, Verheij, Theo J. M., GRACE Consortium, Teepe, J, HAG Infectieziekten, JC onderzoeksprogramma Infectieziekten, Infection & Immunity, Little, Paul, Elshof, Nori, Broekhuizen, Berna D. L., Moore, Michael, Stuart, Beth, Butler, Chris C., Hood, Kerenza, Ieven, Margareta, Coenen, Samuel, Goossens, Herman, Verheij, Theo J. M., GRACE Consortium, and Teepe, J

Published
2016

48. Adherence-adjusted estimates of benefits and harms from treatment with amoxicillin for LRTI : Secondary analysis of a 12-country randomised placebocontrolled trial using randomisationbased efficacy estimators

Author

Gillespie, David, Hood, Kerenza, Farewell, Daniel, Butler, Christopher C., Verheij, Theo, Goossens, Herman, Stuart, Beth, Mullee, Mark, Little, Paul, Gillespie, David, Hood, Kerenza, Farewell, Daniel, Butler, Christopher C., Verheij, Theo, Goossens, Herman, Stuart, Beth, Mullee, Mark, and Little, Paul

Published
2015

49. Validity of a clinical model to predict influenza in patients presenting with symptoms of lower respiratory tract infection in primary care

Author

de Vries-van Vugt, Saskia F., Broekhuizen, Berna D L, Zuithoff, Nicolaas P A, van Essen, Gerrit A., Ebell, Mark H., Coenen, Samuel, Ieven, Margareta, Lammens, Christine, Goossens, Herman, Butler, Chris C., Hood, Kerenza, Littleg, Paul, Verheij, Theo J M, Zuithoff, Peter, van Essen, Ted, Almirall, Jordi, Blasi, Francesco, Chlabicz, Slawomir, Davies, Mel, Godycki-Cwirko, Maciek, Hupkova, Helena, Kersnik, Janko, Mierzecki, Artur, Mölstad, Sigvard, Moore, Michael, Schaberg, Tom, de Sutter, An, Torres, Antoni, Touboul, Pia, Little, Paul, Verheij, Theo, de Vries-van Vugt, Saskia F., Broekhuizen, Berna D L, Zuithoff, Nicolaas P A, van Essen, Gerrit A., Ebell, Mark H., Coenen, Samuel, Ieven, Margareta, Lammens, Christine, Goossens, Herman, Butler, Chris C., Hood, Kerenza, Littleg, Paul, Verheij, Theo J M, Zuithoff, Peter, van Essen, Ted, Almirall, Jordi, Blasi, Francesco, Chlabicz, Slawomir, Davies, Mel, Godycki-Cwirko, Maciek, Hupkova, Helena, Kersnik, Janko, Mierzecki, Artur, Mölstad, Sigvard, Moore, Michael, Schaberg, Tom, de Sutter, An, Torres, Antoni, Touboul, Pia, Little, Paul, and Verheij, Theo

Published
2015

50. Adherence-adjusted estimates of benefits and harms from treatment with amoxicillin for LRTI : Secondary analysis of a 12-country randomised placebocontrolled trial using randomisationbased efficacy estimators

Author

Gillespie, David, Hood, Kerenza, Farewell, Daniel, Butler, Christopher C., Verheij, Theo, Goossens, Herman, Stuart, Beth, Mullee, Mark, Little, Paul, Gillespie, David, Hood, Kerenza, Farewell, Daniel, Butler, Christopher C., Verheij, Theo, Goossens, Herman, Stuart, Beth, Mullee, Mark, and Little, Paul

Published
2015

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