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Background: The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) showed cognitive benefits from a multidomain lifestyle intervention in at-risk older people. The LipiDiDiet trial highlighted benefits of medical food in prodromal Alzheimer’s disease (AD). However, the feasibility and impact of multimodal interventions combining lifestyle with medical food in prodromal AD is unclear. Methods: MIND-ADmini was a 6-month multinational (Sweden, Finland, Germany, France) proof-of-concept randomized controlled trial (RCT). Participants were 60–85 years old, had prodromal AD (International Working Group-1 criteria), and vascular/lifestyle risk factors. The parallel-group RCT had three arms: multimodal lifestyle intervention (nutritional guidance, exercise, cognitive training, vascular/metabolic risk management and social stimulation); multimodal lifestyle intervention + medical food (Fortasyn Connect); and regular health advice/care (control). Participants were randomized 1:1:1 (computer-generated allocation at each site). Outcome evaluators were blinded to randomization. Primary outcome was feasibility of the multimodal intervention, evaluated by recruitment rate during a 6-month recruitment phase, overall adherence in each intervention arm, and 6-month retention rate. Successful adherence was pre-specified as attending ≥ 40% of sessions/domain in ≥ 2/4 domains (lifestyle intervention), and consuming ≥ 60% of the medical food (lifestyle intervention + medical food). The secondary outcomes included adherence/participation to each intervention component and overall adherence to healthy lifestyle changes, measured using a composite score for healthy lifestyle. Cognitive assessments were included as exploratory outcomes, e.g. Clinical Dementia Rating scale. Results: During September 2017-May 2019, 93 individuals were randomized (32 lifestyle intervention, 31 lifestyle + medical food, and 30 control group). Overall recruitment rate was

Background The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) showed cognitive benefits from a multidomain lifestyle intervention in at-risk older people. The LipiDiDiet trial highlighted benefits of medical food in prodromal Alzheimer’s disease (AD). However, the feasibility and impact of multimodal interventions combining lifestyle with medical food in prodromal AD is unclear. Methods MIND-ADmini was a 6-month multinational (Sweden, Finland, Germany, France) proof-of-concept randomized controlled trial (RCT). Participants were 60–85 years old, had prodromal AD (International Working Group-1 criteria), and vascular/lifestyle risk factors. The parallel-group RCT had three arms: multimodal lifestyle intervention (nutritional guidance, exercise, cognitive training, vascular/metabolic risk management and social stimulation); multimodal lifestyle intervention + medical food (Fortasyn Connect); and regular health advice/care (control). Participants were randomized 1:1:1 (computer-generated allocation at each site). Outcome evaluators were blinded to randomization. Primary outcome was feasibility of the multimodal intervention, evaluated by recruitment rate during a 6-month recruitment phase, overall adherence in each intervention arm, and 6-month retention rate. Successful adherence was pre-specified as attending ≥ 40% of sessions/domain in ≥ 2/4 domains (lifestyle intervention), and consuming ≥ 60% of the medical food (lifestyle intervention + medical food). The secondary outcomes included adherence/participation to each intervention component and overall adherence to healthy lifestyle changes, measured using a composite score for healthy lifestyle. Cognitive assessments were included as exploratory outcomes, e.g. Clinical Dementia Rating scale. ResultsDuring September 2017-May 2019, 93 individuals were randomized (32 lifestyle intervention, 31 lifestyle + medical food, and 30 control group). Overall recruitment rate was 76.

Background: The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) showed cognitive benefits from a multidomain lifestyle intervention in at-risk older people. The LipiDiDiet trial highlighted benefits of medical food in prodromal Alzheimer’s disease (AD). However, the feasibility and impact of multimodal interventions combining lifestyle with medical food in prodromal AD is unclear. Methods: MIND-ADmini was a 6-month multinational (Sweden, Finland, Germany, France) proof-of-concept randomized controlled trial (RCT). Participants were 60–85 years old, had prodromal AD (International Working Group-1 criteria), and vascular/lifestyle risk factors. The parallel-group RCT had three arms: multimodal lifestyle intervention (nutritional guidance, exercise, cognitive training, vascular/metabolic risk management and social stimulation); multimodal lifestyle intervention + medical food (Fortasyn Connect); and regular health advice/care (control). Participants were randomized 1:1:1 (computer-generated allocation at each site). Outcome evaluators were blinded to randomization. Primary outcome was feasibility of the multimodal intervention, evaluated by recruitment rate during a 6-month recruitment phase, overall adherence in each intervention arm, and 6-month retention rate. Successful adherence was pre-specified as attending ≥ 40% of sessions/domain in ≥ 2/4 domains (lifestyle intervention), and consuming ≥ 60% of the medical food (lifestyle intervention + medical food). The secondary outcomes included adherence/participation to each intervention component and overall adherence to healthy lifestyle changes, measured using a composite score for healthy lifestyle. Cognitive assessments were included as exploratory outcomes, e.g. Clinical Dementia Rating scale. Results: During September 2017-May 2019, 93 individuals were randomized (32 lifestyle intervention, 31 lifestyle + medical food, and 30 control group). Overall recruitment rate was

Background: The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) showed cognitive benefits from a multidomain lifestyle intervention in at-risk older people. The LipiDiDiet trial highlighted benefits of medical food in prodromal Alzheimer’s disease (AD). However, the feasibility and impact of multimodal interventions combining lifestyle with medical food in prodromal AD is unclear. Methods: MIND-ADmini was a 6-month multinational (Sweden, Finland, Germany, France) proof-of-concept randomized controlled trial (RCT). Participants were 60–85 years old, had prodromal AD (International Working Group-1 criteria), and vascular/lifestyle risk factors. The parallel-group RCT had three arms: multimodal lifestyle intervention (nutritional guidance, exercise, cognitive training, vascular/metabolic risk management and social stimulation); multimodal lifestyle intervention + medical food (Fortasyn Connect); and regular health advice/care (control). Participants were randomized 1:1:1 (computer-generated allocation at each site). Outcome evaluators were blinded to randomization. Primary outcome was feasibility of the multimodal intervention, evaluated by recruitment rate during a 6-month recruitment phase, overall adherence in each intervention arm, and 6-month retention rate. Successful adherence was pre-specified as attending ≥ 40% of sessions/domain in ≥ 2/4 domains (lifestyle intervention), and consuming ≥ 60% of the medical food (lifestyle intervention + medical food). The secondary outcomes included adherence/participation to each intervention component and overall adherence to healthy lifestyle changes, measured using a composite score for healthy lifestyle. Cognitive assessments were included as exploratory outcomes, e.g. Clinical Dementia Rating scale. Results: During September 2017-May 2019, 93 individuals were randomized (32 lifestyle intervention, 31 lifestyle + medical food, and 30 control group). Overall recruitment rate was

BACKGROUND: The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) showed cognitive benefits from a multidomain lifestyle intervention in at-risk older people. The LipiDiDiet trial highlighted benefits of medical food in prodromal Alzheimer's disease (AD). However, the feasibility and impact of multimodal interventions combining lifestyle with medical food in prodromal AD is unclear. METHODS: MIND-ADmini was a 6-month multinational (Sweden, Finland, Germany, France) proof-of-concept randomized controlled trial (RCT). Participants were 60-85 years old, had prodromal AD (International Working Group-1 criteria), and vascular/lifestyle risk factors. The parallel-group RCT had three arms: multimodal lifestyle intervention (nutritional guidance, exercise, cognitive training, vascular/metabolic risk management and social stimulation); multimodal lifestyle intervention + medical food (Fortasyn Connect); and regular health advice/care (control). Participants were randomized 1:1:1 (computer-generated allocation at each site). Outcome evaluators were blinded to randomization. Primary outcome was feasibility of the multimodal intervention, evaluated by recruitment rate during a 6-month recruitment phase, overall adherence in each intervention arm, and 6-month retention rate. Successful adherence was pre-specified as attending ≥ 40% of sessions/domain in ≥ 2/4 domains (lifestyle intervention), and consuming ≥ 60% of the medical food (lifestyle intervention + medical food). The secondary outcomes included adherence/participation to each intervention component and overall adherence to healthy lifestyle changes, measured using a composite score for healthy lifestyle. Cognitive assessments were included as exploratory outcomes, e.g. Clinical Dementia Rating scale. RESULTS: During September 2017-May 2019, 93 individuals were randomized (32 lifestyle intervention, 31 lifestyle + medical food, and 30 control group). Overall recruitment rate was

Background The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) showed cognitive benefits from a multidomain lifestyle intervention in at-risk older people. The LipiDiDiet trial highlighted benefits of medical food in prodromal Alzheimer’s disease (AD). However, the feasibility and impact of multimodal interventions combining lifestyle with medical food in prodromal AD is unclear. Methods MIND-ADmini was a 6-month multinational (Sweden, Finland, Germany, France) proof-of-concept randomized controlled trial (RCT). Participants were 60–85 years old, had prodromal AD (International Working Group-1 criteria), and vascular/lifestyle risk factors. The parallel-group RCT had three arms: multimodal lifestyle intervention (nutritional guidance, exercise, cognitive training, vascular/metabolic risk management and social stimulation); multimodal lifestyle intervention + medical food (Fortasyn Connect); and regular health advice/care (control). Participants were randomized 1:1:1 (computer-generated allocation at each site). Outcome evaluators were blinded to randomization. Primary outcome was feasibility of the multimodal intervention, evaluated by recruitment rate during a 6-month recruitment phase, overall adherence in each intervention arm, and 6-month retention rate. Successful adherence was pre-specified as attending ≥ 40% of sessions/domain in ≥ 2/4 domains (lifestyle intervention), and consuming ≥ 60% of the medical food (lifestyle intervention + medical food). The secondary outcomes included adherence/participation to each intervention component and overall adherence to healthy lifestyle changes, measured using a composite score for healthy lifestyle. Cognitive assessments were included as exploratory outcomes, e.g. Clinical Dementia Rating scale. ResultsDuring September 2017-May 2019, 93 individuals were randomized (32 lifestyle intervention, 31 lifestyle + medical food, and 30 control group). Overall recruitment rate was 76.

BACKGROUND: The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) showed cognitive benefits from a multidomain lifestyle intervention in at-risk older people. The LipiDiDiet trial highlighted benefits of medical food in prodromal Alzheimer's disease (AD). However, the feasibility and impact of multimodal interventions combining lifestyle with medical food in prodromal AD is unclear. METHODS: MIND-ADmini was a 6-month multinational (Sweden, Finland, Germany, France) proof-of-concept randomized controlled trial (RCT). Participants were 60-85 years old, had prodromal AD (International Working Group-1 criteria), and vascular/lifestyle risk factors. The parallel-group RCT had three arms: multimodal lifestyle intervention (nutritional guidance, exercise, cognitive training, vascular/metabolic risk management and social stimulation); multimodal lifestyle intervention + medical food (Fortasyn Connect); and regular health advice/care (control). Participants were randomized 1:1:1 (computer-generated allocation at each site). Outcome evaluators were blinded to randomization. Primary outcome was feasibility of the multimodal intervention, evaluated by recruitment rate during a 6-month recruitment phase, overall adherence in each intervention arm, and 6-month retention rate. Successful adherence was pre-specified as attending ≥ 40% of sessions/domain in ≥ 2/4 domains (lifestyle intervention), and consuming ≥ 60% of the medical food (lifestyle intervention + medical food). The secondary outcomes included adherence/participation to each intervention component and overall adherence to healthy lifestyle changes, measured using a composite score for healthy lifestyle. Cognitive assessments were included as exploratory outcomes, e.g. Clinical Dementia Rating scale. RESULTS: During September 2017-May 2019, 93 individuals were randomized (32 lifestyle intervention, 31 lifestyle + medical food, and 30 control group). Overall recruitment rate was

Background The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) showed cognitive benefits from a multidomain lifestyle intervention in at-risk older people. The LipiDiDiet trial highlighted benefits of medical food in prodromal Alzheimer’s disease (AD). However, the feasibility and impact of multimodal interventions combining lifestyle with medical food in prodromal AD is unclear. Methods MIND-ADmini was a 6-month multinational (Sweden, Finland, Germany, France) proof-of-concept randomized controlled trial (RCT). Participants were 60–85 years old, had prodromal AD (International Working Group-1 criteria), and vascular/lifestyle risk factors. The parallel-group RCT had three arms: multimodal lifestyle intervention (nutritional guidance, exercise, cognitive training, vascular/metabolic risk management and social stimulation); multimodal lifestyle intervention + medical food (Fortasyn Connect); and regular health advice/care (control). Participants were randomized 1:1:1 (computer-generated allocation at each site). Outcome evaluators were blinded to randomization. Primary outcome was feasibility of the multimodal intervention, evaluated by recruitment rate during a 6-month recruitment phase, overall adherence in each intervention arm, and 6-month retention rate. Successful adherence was pre-specified as attending ≥ 40% of sessions/domain in ≥ 2/4 domains (lifestyle intervention), and consuming ≥ 60% of the medical food (lifestyle intervention + medical food). The secondary outcomes included adherence/participation to each intervention component and overall adherence to healthy lifestyle changes, measured using a composite score for healthy lifestyle. Cognitive assessments were included as exploratory outcomes, e.g. Clinical Dementia Rating scale. ResultsDuring September 2017-May 2019, 93 individuals were randomized (32 lifestyle intervention, 31 lifestyle + medical food, and 30 control group). Overall recruitment rate was 76.

BACKGROUND: The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) showed cognitive benefits from a multidomain lifestyle intervention in at-risk older people. The LipiDiDiet trial highlighted benefits of medical food in prodromal Alzheimer's disease (AD). However, the feasibility and impact of multimodal interventions combining lifestyle with medical food in prodromal AD is unclear. METHODS: MIND-ADmini was a 6-month multinational (Sweden, Finland, Germany, France) proof-of-concept randomized controlled trial (RCT). Participants were 60-85 years old, had prodromal AD (International Working Group-1 criteria), and vascular/lifestyle risk factors. The parallel-group RCT had three arms: multimodal lifestyle intervention (nutritional guidance, exercise, cognitive training, vascular/metabolic risk management and social stimulation); multimodal lifestyle intervention + medical food (Fortasyn Connect); and regular health advice/care (control). Participants were randomized 1:1:1 (computer-generated allocation at each site). Outcome evaluators were blinded to randomization. Primary outcome was feasibility of the multimodal intervention, evaluated by recruitment rate during a 6-month recruitment phase, overall adherence in each intervention arm, and 6-month retention rate. Successful adherence was pre-specified as attending ≥ 40% of sessions/domain in ≥ 2/4 domains (lifestyle intervention), and consuming ≥ 60% of the medical food (lifestyle intervention + medical food). The secondary outcomes included adherence/participation to each intervention component and overall adherence to healthy lifestyle changes, measured using a composite score for healthy lifestyle. Cognitive assessments were included as exploratory outcomes, e.g. Clinical Dementia Rating scale. RESULTS: During September 2017-May 2019, 93 individuals were randomized (32 lifestyle intervention, 31 lifestyle + medical food, and 30 control group). Overall recruitment rate was

Background: Fertilization with organic waste compost can close the nutrient cycles between urban and rural environments. However, its effect on yield and soil fertility must be investigated. Aim: This study investigated the long-term effect of compost on soil nutrient and potentially toxic elements (PTEs) concentration, nutrient budgets, and nitrogen (N) mineralization and efficiency. Methods: After 21 years of annual compost application (100/400 kg N ha–1 year–1 [100BC/400BC]) alone and combined with mineral fertilization, soil was analyzed for pH, organic carbon (SOC), nutrient (total N and P, Nmin, extractable CAL-P, CAL-K, and Mg), and PTE (Cu, Ni, Zn) concentrations. Yields were recorded and nutrient/PTE budgets and apparent netmineralization (ANM, only 2019) were calculated. Results:Nefficiency was the highest in maize and formineral fertilization. Compost application led to lower N efficiencies, but increased ANM, SOC, pH, and soil N, and surpluses of N, P, and all PTEs. Higher PTE concentrations were only found in 400BC for Cu. Nutrient budgets correlatedwith soil nutrient concentration. A surplus of 16.1 kg P ha–1 year–1 and 19.5 kgKha–1 year–1 resulted in 1mg kg–1 increase in CAL-P and CAL-K over 21 years. Conclusion: Compost application supplies nutrients to crops with a minor risk of soilaccumulation of PTEs. However, the nutrient stoichiometry provided by compost does not match crop offtakes causing imbalances. Synchronization of compost N mineralization and plant N demand does not match and limits the yield effect. In winter wheat only 65–70% of Nmineralization occurred during the growth period.

Background: Fertilization with organic waste compost can close the nutrient cycles between urban and rural environments. However, its effect on yield and soil fertility must be investigated. Aim: This study investigated the long-term effect of compost on soil nutrient and potentially toxic elements (PTEs) concentration, nutrient budgets, and nitrogen (N) mineralization and efficiency. Methods: After 21 years of annual compost application (100/400 kg N ha–1 year–1 [100BC/400BC]) alone and combined with mineral fertilization, soil was analyzed for pH, organic carbon (SOC), nutrient (total N and P, Nmin, extractable CAL-P, CAL-K, and Mg), and PTE (Cu, Ni, Zn) concentrations. Yields were recorded and nutrient/PTE budgets and apparent netmineralization (ANM, only 2019) were calculated. Results:Nefficiency was the highest in maize and formineral fertilization. Compost application led to lower N efficiencies, but increased ANM, SOC, pH, and soil N, and surpluses of N, P, and all PTEs. Higher PTE concentrations were only found in 400BC for Cu. Nutrient budgets correlatedwith soil nutrient concentration. A surplus of 16.1 kg P ha–1 year–1 and 19.5 kgKha–1 year–1 resulted in 1mg kg–1 increase in CAL-P and CAL-K over 21 years. Conclusion: Compost application supplies nutrients to crops with a minor risk of soilaccumulation of PTEs. However, the nutrient stoichiometry provided by compost does not match crop offtakes causing imbalances. Synchronization of compost N mineralization and plant N demand does not match and limits the yield effect. In winter wheat only 65–70% of Nmineralization occurred during the growth period.

Background: Fertilization with organic waste compost can close the nutrient cycles between urban and rural environments. However, its effect on yield and soil fertility must be investigated. Aim: This study investigated the long-term effect of compost on soil nutrient and potentially toxic elements (PTEs) concentration, nutrient budgets, and nitrogen (N) mineralization and efficiency. Methods: After 21 years of annual compost application (100/400 kg N ha–1 year–1 [100BC/400BC]) alone and combined with mineral fertilization, soil was analyzed for pH, organic carbon (SOC), nutrient (total N and P, Nmin, extractable CAL-P, CAL-K, and Mg), and PTE (Cu, Ni, Zn) concentrations. Yields were recorded and nutrient/PTE budgets and apparent netmineralization (ANM, only 2019) were calculated. Results:Nefficiency was the highest in maize and formineral fertilization. Compost application led to lower N efficiencies, but increased ANM, SOC, pH, and soil N, and surpluses of N, P, and all PTEs. Higher PTE concentrations were only found in 400BC for Cu. Nutrient budgets correlatedwith soil nutrient concentration. A surplus of 16.1 kg P ha–1 year–1 and 19.5 kgKha–1 year–1 resulted in 1mg kg–1 increase in CAL-P and CAL-K over 21 years. Conclusion: Compost application supplies nutrients to crops with a minor risk of soilaccumulation of PTEs. However, the nutrient stoichiometry provided by compost does not match crop offtakes causing imbalances. Synchronization of compost N mineralization and plant N demand does not match and limits the yield effect. In winter wheat only 65–70% of Nmineralization occurred during the growth period.

Background: Fertilization with organic waste compost can close the nutrient cycles between urban and rural environments. However, its effect on yield and soil fertility must be investigated. Aim: This study investigated the long-term effect of compost on soil nutrient and potentially toxic elements (PTEs) concentration, nutrient budgets, and nitrogen (N) mineralization and efficiency. Methods: After 21 years of annual compost application (100/400 kg N ha–1 year–1 [100BC/400BC]) alone and combined with mineral fertilization, soil was analyzed for pH, organic carbon (SOC), nutrient (total N and P, Nmin, extractable CAL-P, CAL-K, and Mg), and PTE (Cu, Ni, Zn) concentrations. Yields were recorded and nutrient/PTE budgets and apparent netmineralization (ANM, only 2019) were calculated. Results:Nefficiency was the highest in maize and formineral fertilization. Compost application led to lower N efficiencies, but increased ANM, SOC, pH, and soil N, and surpluses of N, P, and all PTEs. Higher PTE concentrations were only found in 400BC for Cu. Nutrient budgets correlatedwith soil nutrient concentration. A surplus of 16.1 kg P ha–1 year–1 and 19.5 kgKha–1 year–1 resulted in 1mg kg–1 increase in CAL-P and CAL-K over 21 years. Conclusion: Compost application supplies nutrients to crops with a minor risk of soilaccumulation of PTEs. However, the nutrient stoichiometry provided by compost does not match crop offtakes causing imbalances. Synchronization of compost N mineralization and plant N demand does not match and limits the yield effect. In winter wheat only 65–70% of Nmineralization occurred during the growth period.

Background: Fertilization with organic waste compost can close the nutrient cycles between urban and rural environments. However, its effect on yield and soil fertility must be investigated. Aim: This study investigated the long-term effect of compost on soil nutrient and potentially toxic elements (PTEs) concentration, nutrient budgets, and nitrogen (N) mineralization and efficiency. Methods: After 21 years of annual compost application (100/400 kg N ha–1 year–1 [100BC/400BC]) alone and combined with mineral fertilization, soil was analyzed for pH, organic carbon (SOC), nutrient (total N and P, Nmin, extractable CAL-P, CAL-K, and Mg), and PTE (Cu, Ni, Zn) concentrations. Yields were recorded and nutrient/PTE budgets and apparent netmineralization (ANM, only 2019) were calculated. Results:Nefficiency was the highest in maize and formineral fertilization. Compost application led to lower N efficiencies, but increased ANM, SOC, pH, and soil N, and surpluses of N, P, and all PTEs. Higher PTE concentrations were only found in 400BC for Cu. Nutrient budgets correlatedwith soil nutrient concentration. A surplus of 16.1 kg P ha–1 year–1 and 19.5 kgKha–1 year–1 resulted in 1mg kg–1 increase in CAL-P and CAL-K over 21 years. Conclusion: Compost application supplies nutrients to crops with a minor risk of soilaccumulation of PTEs. However, the nutrient stoichiometry provided by compost does not match crop offtakes causing imbalances. Synchronization of compost N mineralization and plant N demand does not match and limits the yield effect. In winter wheat only 65–70% of Nmineralization occurred during the growth period.

Background: Fertilization with organic waste compost can close the nutrient cycles between urban and rural environments. However, its effect on yield and soil fertility must be investigated. Aim: This study investigated the long-term effect of compost on soil nutrient and potentially toxic elements (PTEs) concentration, nutrient budgets, and nitrogen (N) mineralization and efficiency. Methods: After 21 years of annual compost application (100/400 kg N ha–1 year–1 [100BC/400BC]) alone and combined with mineral fertilization, soil was analyzed for pH, organic carbon (SOC), nutrient (total N and P, Nmin, extractable CAL-P, CAL-K, and Mg), and PTE (Cu, Ni, Zn) concentrations. Yields were recorded and nutrient/PTE budgets and apparent netmineralization (ANM, only 2019) were calculated. Results:Nefficiency was the highest in maize and formineral fertilization. Compost application led to lower N efficiencies, but increased ANM, SOC, pH, and soil N, and surpluses of N, P, and all PTEs. Higher PTE concentrations were only found in 400BC for Cu. Nutrient budgets correlatedwith soil nutrient concentration. A surplus of 16.1 kg P ha–1 year–1 and 19.5 kgKha–1 year–1 resulted in 1mg kg–1 increase in CAL-P and CAL-K over 21 years. Conclusion: Compost application supplies nutrients to crops with a minor risk of soilaccumulation of PTEs. However, the nutrient stoichiometry provided by compost does not match crop offtakes causing imbalances. Synchronization of compost N mineralization and plant N demand does not match and limits the yield effect. In winter wheat only 65–70% of Nmineralization occurred during the growth period.

Background: Fertilization with organic waste compost can close the nutrient cycles between urban and rural environments. However, its effect on yield and soil fertility must be investigated. Aim: This study investigated the long-term effect of compost on soil nutrient and potentially toxic elements (PTEs) concentration, nutrient budgets, and nitrogen (N) mineralization and efficiency. Methods: After 21 years of annual compost application (100/400 kg N ha–1 year–1 [100BC/400BC]) alone and combined with mineral fertilization, soil was analyzed for pH, organic carbon (SOC), nutrient (total N and P, Nmin, extractable CAL-P, CAL-K, and Mg), and PTE (Cu, Ni, Zn) concentrations. Yields were recorded and nutrient/PTE budgets and apparent netmineralization (ANM, only 2019) were calculated. Results:Nefficiency was the highest in maize and formineral fertilization. Compost application led to lower N efficiencies, but increased ANM, SOC, pH, and soil N, and surpluses of N, P, and all PTEs. Higher PTE concentrations were only found in 400BC for Cu. Nutrient budgets correlatedwith soil nutrient concentration. A surplus of 16.1 kg P ha–1 year–1 and 19.5 kgKha–1 year–1 resulted in 1mg kg–1 increase in CAL-P and CAL-K over 21 years. Conclusion: Compost application supplies nutrients to crops with a minor risk of soilaccumulation of PTEs. However, the nutrient stoichiometry provided by compost does not match crop offtakes causing imbalances. Synchronization of compost N mineralization and plant N demand does not match and limits the yield effect. In winter wheat only 65–70% of Nmineralization occurred during the growth period.

Background: Fertilization with organic waste compost can close the nutrient cycles between urban and rural environments. However, its effect on yield and soil fertility must be investigated. Aim: This study investigated the long-term effect of compost on soil nutrient and potentially toxic elements (PTEs) concentration, nutrient budgets, and nitrogen (N) mineralization and efficiency. Methods: After 21 years of annual compost application (100/400 kg N ha–1 year–1 [100BC/400BC]) alone and combined with mineral fertilization, soil was analyzed for pH, organic carbon (SOC), nutrient (total N and P, Nmin, extractable CAL-P, CAL-K, and Mg), and PTE (Cu, Ni, Zn) concentrations. Yields were recorded and nutrient/PTE budgets and apparent netmineralization (ANM, only 2019) were calculated. Results:Nefficiency was the highest in maize and formineral fertilization. Compost application led to lower N efficiencies, but increased ANM, SOC, pH, and soil N, and surpluses of N, P, and all PTEs. Higher PTE concentrations were only found in 400BC for Cu. Nutrient budgets correlatedwith soil nutrient concentration. A surplus of 16.1 kg P ha–1 year–1 and 19.5 kgKha–1 year–1 resulted in 1mg kg–1 increase in CAL-P and CAL-K over 21 years. Conclusion: Compost application supplies nutrients to crops with a minor risk of soilaccumulation of PTEs. However, the nutrient stoichiometry provided by compost does not match crop offtakes causing imbalances. Synchronization of compost N mineralization and plant N demand does not match and limits the yield effect. In winter wheat only 65–70% of Nmineralization occurred during the growth period.

QC 20211019

Many clinical trials repeatedly measure several longitudinal outcomes on patients. Patient follow-up can discontinue due to an outcome-dependent event, such as clinical diagnosis, death, or dropout. Joint modeling is a popular choice for the analysis of this type of data. Using example data from a prodromal Alzheimer's disease trial, we propose a new type of multivariate joint model in which longitudinal brain imaging outcomes and memory impairment ratings are allowed to be associated both with time to open-label medication and dropout, and where the brain imaging outcomes may also directly affect the memory impairment ratings. Existing joint models for multivariate longitudinal outcomes account for the correlation between the longitudinal outcomes through the random effects, often by assuming a multivariate normal distribution. However, for these models, it is difficult to interpret how the longitudinal outcomes affect each other. We model the dependence between the longitudinal outcomes differently so that a first longitudinal outcome affects a second one. Specifically, for each longitudinal outcome, we use a linear mixed-effects model to estimate its trajectory, where, for the second longitudinal outcome, we include the linear predictor of the first outcome as a time-varying covariate. This facilitates an easy and direct interpretation of the association between the longitudinal outcomes and provides a framework for latent mediation analysis to understand the underlying biological processes. For the trial considered here, we found that part of the intervention effect is mediated through hippocampal brain atrophy. The proposed joint models are fitted using a Bayesian framework via MCMC simulation.

Knowledge of nutrient budgets of organic farms and their effect on soil nutrient contents across Europe is relatively limited. Therefore, a meta-analysis was conducted to investigate the nutrient supply of organic farms as affected by budgeting method, farm type and studied country. Further, an assessment was performed relating nutrient budgets with soil nutrient contents across five countries. We found an average surplus of N, an almost balanced budget for P and a deficit for K. Yet, nutrient budgets varied over a wide range. Farm type, more than the studied country or budgeting method, was able to explain some of the variations, with vegetable farms having higher surpluses, especially for N, than dairy farms, followed by mixed or stockless farms. Soil nutrient contents showed also considerable differences among farms and countries. A relationship between soil nutrient content and budget was found only for P, which indicates negative P budgets as a real risk for soil P depletion.

Rapid urbanization has decoupled phosphorus (P) urban consumption and hinterland production, which has accelerated the need for a broader perspective that includes the city and hinterland in managing the P cycle. However, there is a scarcity of frameworks for the combined city and hinterland approach, aimed at quantifying the transboundary P flow between the city and hinterland. In this study, we developed a coupled city-hinterland framework (using Beijing as a case study) to assess the P flow pattern at the source, waste, and transboundary flow using substance flow analysis, and proposed a pathway to identify the key subsystem in the coupled system by sensitivity analysis. Results shows that the P waste within Beijing is due to human consumption, rather than production, while P waste in the hinterland was nearly twice that observed in Beijing. Further, hinterland crop production subsystems were identified as the key subsystem to reduce P rock demand for the whole coupled system; 39% of P rock demand could be reduced by optimizing fertilizer use in the hinterland. In the scenarios that consider an improvement in technology both in Beijing and its hinterland, 64% and 60% of the total P rock demand and waste were reduced, respectively. Therefore, we provided suggestions to reduce P waste in the coupled system. This study provides a broader perspective to evaluate the impacts of urban consumption on the hinterland, which will serve as a basis for policy decisions for sustainable P flow in the supply chain of other similar cities., QC 20211206

Knowledge of nutrient budgets of organic farms and their effect on soil nutrient contents across Europe is relatively limited. Therefore, a meta-analysis was conducted to investigate the nutrient supply of organic farms as affected by budgeting method, farm type and studied country. Further, an assessment was performed relating nutrient budgets with soil nutrient contents across five countries. We found an average surplus of N, an almost balanced budget for P and a deficit for K. Yet, nutrient budgets varied over a wide range. Farm type, more than the studied country or budgeting method, was able to explain some of the variations, with vegetable farms having higher surpluses, especially for N, than dairy farms, followed by mixed or stockless farms. Soil nutrient contents showed also considerable differences among farms and countries. A relationship between soil nutrient content and budget was found only for P, which indicates negative P budgets as a real risk for soil P depletion.

Knowledge of nutrient budgets of organic farms and their effect on soil nutrient contents across Europe is relatively limited. Therefore, a meta-analysis was conducted to investigate the nutrient supply of organic farms as affected by budgeting method, farm type and studied country. Further, an assessment was performed relating nutrient budgets with soil nutrient contents across five countries. We found an average surplus of N, an almost balanced budget for P and a deficit for K. Yet, nutrient budgets varied over a wide range. Farm type, more than the studied country or budgeting method, was able to explain some of the variations, with vegetable farms having higher surpluses, especially for N, than dairy farms, followed by mixed or stockless farms. Soil nutrient contents showed also considerable differences among farms and countries. A relationship between soil nutrient content and budget was found only for P, which indicates negative P budgets as a real risk for soil P depletion.

Knowledge of nutrient budgets of organic farms and their effect on soil nutrient contents across Europe is relatively limited. Therefore, a meta-analysis was conducted to investigate the nutrient supply of organic farms as affected by budgeting method, farm type and studied country. Further, an assessment was performed relating nutrient budgets with soil nutrient contents across five countries. We found an average surplus of N, an almost balanced budget for P and a deficit for K. Yet, nutrient budgets varied over a wide range. Farm type, more than the studied country or budgeting method, was able to explain some of the variations, with vegetable farms having higher surpluses, especially for N, than dairy farms, followed by mixed or stockless farms. Soil nutrient contents showed also considerable differences among farms and countries. A relationship between soil nutrient content and budget was found only for P, which indicates negative P budgets as a real risk for soil P depletion.

Reducing the risk of dementia can halt the worldwide increase of affected people. The multifactorial and heterogeneous nature of late-onset dementia, including Alzheimer's disease (AD), indicates a potential impact of multidomain lifestyle interventions on risk reduction. The positive results of the landmark multidomain Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) support such an approach. The World-Wide FINGERS (WW-FINGERS), launched in 2017 and including over 25 countries, is the first global network of multidomain lifestyle intervention trials for dementia risk reduction and prevention. WW-FINGERS aims to adapt, test, and optimize the FINGER model to reduce risk across the spectrum of cognitive decline-from at-risk asymptomatic states to early symptomatic stages-in different geographical, cultural, and economic settings. WW-FINGERS aims to harmonize and adapt multidomain interventions across various countries and settings, to facilitate data sharing and analysis across studies, and to promote international joint initiatives to identify globally implementable and effective preventive strategies.

Reducing the risk of dementia can halt the worldwide increase of affected people. The multifactorial and heterogeneous nature of late-onset dementia, including Alzheimer's disease (AD), indicates a potential impact of multidomain lifestyle interventions on risk reduction. The positive results of the landmark multidomain Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) support such an approach. The World-Wide FINGERS (WW-FINGERS), launched in 2017 and including over 25 countries, is the first global network of multidomain lifestyle intervention trials for dementia risk reduction and prevention. WW-FINGERS aims to adapt, test, and optimize the FINGER model to reduce risk across the spectrum of cognitive decline-from at-risk asymptomatic states to early symptomatic stages-in different geographical, cultural, and economic settings. WW-FINGERS aims to harmonize and adapt multidomain interventions across various countries and settings, to facilitate data sharing and analysis across studies, and to promote international joint initiatives to identify globally implementable and effective preventive strategies.

© 2020 The Authors. Alzheimer's & Dementia published by Wiley Periodicals, Inc. on behalf of Alzheimer's Association Reducing the risk of dementia can halt the worldwide increase of affected people. The multifactorial and heterogeneous nature of late-onset dementia, including Alzheimer's disease (AD), indicates a potential impact of multidomain lifestyle interventions on risk reduction. The positive results of the landmark multidomain Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) support such an approach. The World-Wide FINGERS (WW-FINGERS), launched in 2017 and including over 25 countries, is the first global network of multidomain lifestyle intervention trials for dementia risk reduction and prevention. WW-FINGERS aims to adapt, test, and optimize the FINGER model to reduce risk across the spectrum of cognitive decline—from at-risk asymptomatic states to early symptomatic stages—in different geographical, cultural, and economic settings. WW-FINGERS aims to harmonize and adapt multidomain interventions across various countries and settings, to facilitate data sharing and analysis across studies, and to promote international joint initiatives to identify globally implementable and effective preventive strategies.

Objectives: To implement a multi-year nation-wide programme, by the means of a personalised lifestyle intervention, to prevent or to delay cognitive decline that can contribute to development of dementia in Luxembourg. Methods: Participants with mild cognitive impairment, referred to the programme by their treating physician, undergo an extensive cognitive evaluation by a neuropsychologist on relevant neuropsychological domains as well as a structured dementia risk factor assessment. Based on these assessments, individualised lifestyle interventions are offered by diverse national partners involved in the programme, thus filling a gap of not yet reimbursed services in the Luxemburgish healthcare system. After the personalised lifestyle interventions, each participant will undergo a neuropsychological follow-up in order to re-evaluate his/her health status in terms of cognition. Results: We established a participant-centred national network by presenting the programme on many outreach events and efficient stakeholder communication. The network raises the awareness of dementia prevention in the Luxembourgish population, fosters interdisciplinary communication between individual medical and non-medical healthcare professionals and allows for a successful recruitment of the target population. Moreover, we collect information about adherence to the suggested lifestyle changes, as well as the effectiveness of our interventions in reducing risk factors contributing to the onset of dementia. Conclusions: We provide evidence for the feasibility of the implementation of a nation-wide dementia prevention programme including diverse partners offering personalised lifestyle interventions, which are easily transferrable to other countries. Future results from this programme may also help to integrate prevention interventions into the regular healthcare system.

Reducing the risk of dementia can halt the worldwide increase of affected people. The multifactorial and heterogeneous nature of late-onset dementia, including Alzheimer's disease (AD), indicates a potential impact of multidomain lifestyle interventions on risk reduction. The positive results of the landmark multidomain Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) support such an approach. The World-Wide FINGERS (WW-FINGERS), launched in 2017 and including over 25 countries, is the first global network of multidomain lifestyle intervention trials for dementia risk reduction and prevention. WW-FINGERS aims to adapt, test, and optimize the FINGER model to reduce risk across the spectrum of cognitive decline-from at-risk asymptomatic states to early symptomatic stages-in different geographical, cultural, and economic settings. WW-FINGERS aims to harmonize and adapt multidomain interventions across various countries and settings, to facilitate data sharing and analysis across studies, and to promote international joint initiatives to identify globally implementable and effective preventive strategies.

Nutrient supply to organic farms is a highly discussed topic in Europe, due to the restricted availability of external fertilizer resources and the use of contentious inputs. To optimize the flow of nutrients throughout the organic farming system, it is firstly necessary to obtain valid data on the nutrient status of organic farms. Nutrient budgets are a valid tool to investigate the nutrient demand or surplus of a system. However, there is currently no comprehensive overview of nutrient budgets of European organic farms. We therefore carried out a meta-analysis on 56 individual studies that reported either farm-gate or soil-surface budgets. The analysis showed an imbalance between nutrients, a general surplus of nitrogen (45 kg N ha-1 year-1 [95%-confidence interval (CI): 30, 61]), magnesium (16 kg Mg ha-1 year-1 [-9, 40]) and sulphur (45 kg S ha-1 year-1 [-29, 118]), a balanced phosphorus budget (0 kg P ha-1 year-1 [-2,2]), and a deficit for potassium (-12 kg K ha-1 year-1 [-21, -3]). We observed large differences between farms that could be partly explained by farm type and budgeting method. Arable and mixed farms showed lower nitrogen, phosphor, magnesium and sulphur budgets than dairy/beef farms or even vegetable farms, while all farm types besides dairy/ beef farms showed deficits for K budgets. Further, farm-gate budget studies yielded higher budgets than soil surface budgets. Variations between studied countries could also be detected, but the coverage and comparability is low due to differences in studied farm types and budgeting method.

Nutrient supply to organic farms is a highly discussed topic in Europe, due to the restricted availability of external fertilizer resources and the use of contentious inputs. To optimize the flow of nutrients throughout the organic farming system, it is firstly necessary to obtain valid data on the nutrient status of organic farms. Nutrient budgets are a valid tool to investigate the nutrient demand or surplus of a system. However, there is currently no comprehensive overview of nutrient budgets of European organic farms. We therefore carried out a meta-analysis on 56 individual studies that reported either farm-gate or soil-surface budgets. The analysis showed an imbalance between nutrients, a general surplus of nitrogen (45 kg N ha-1 year-1 [95%-confidence interval (CI): 30, 61]), magnesium (16 kg Mg ha-1 year-1 [-9, 40]) and sulphur (45 kg S ha-1 year-1 [-29, 118]), a balanced phosphorus budget (0 kg P ha-1 year-1 [-2,2]), and a deficit for potassium (-12 kg K ha-1 year-1 [-21, -3]). We observed large differences between farms that could be partly explained by farm type and budgeting method. Arable and mixed farms showed lower nitrogen, phosphor, magnesium and sulphur budgets than dairy/beef farms or even vegetable farms, while all farm types besides dairy/ beef farms showed deficits for K budgets. Further, farm-gate budget studies yielded higher budgets than soil surface budgets. Variations between studied countries could also be detected, but the coverage and comparability is low due to differences in studied farm types and budgeting method.

Nutrient supply to organic farms is a highly discussed topic in Europe, due to the restricted availability of external fertilizer resources and the use of contentious inputs. To optimize the flow of nutrients throughout the organic farming system, it is firstly necessary to obtain valid data on the nutrient status of organic farms. Nutrient budgets are a valid tool to investigate the nutrient demand or surplus of a system. However, there is currently no comprehensive overview of nutrient budgets of European organic farms. We therefore carried out a meta-analysis on 56 individual studies that reported either farm-gate or soil-surface budgets. The analysis showed an imbalance between nutrients, a general surplus of nitrogen (45 kg N ha-1 year-1 [95%-confidence interval (CI): 30, 61]), magnesium (16 kg Mg ha-1 year-1 [-9, 40]) and sulphur (45 kg S ha-1 year-1 [-29, 118]), a balanced phosphorus budget (0 kg P ha-1 year-1 [-2,2]), and a deficit for potassium (-12 kg K ha-1 year-1 [-21, -3]). We observed large differences between farms that could be partly explained by farm type and budgeting method. Arable and mixed farms showed lower nitrogen, phosphor, magnesium and sulphur budgets than dairy/beef farms or even vegetable farms, while all farm types besides dairy/ beef farms showed deficits for K budgets. Further, farm-gate budget studies yielded higher budgets than soil surface budgets. Variations between studied countries could also be detected, but the coverage and comparability is low due to differences in studied farm types and budgeting method.

Nutrient supply to organic farms is a highly discussed topic in Europe, due to the restricted availability of external fertilizer resources and the use of contentious inputs. To optimize the flow of nutrients throughout the organic farming system, it is firstly necessary to obtain valid data on the nutrient status of organic farms. Nutrient budgets are a valid tool to investigate the nutrient demand or surplus of a system. However, there is currently no comprehensive overview of nutrient budgets of European organic farms. We therefore carried out a meta-analysis on 56 individual studies that reported either farm-gate or soil-surface budgets. The analysis showed an imbalance between nutrients, a general surplus of nitrogen (45 kg N ha-1 year-1 [95%-confidence interval (CI): 30, 61]), magnesium (16 kg Mg ha-1 year-1 [-9, 40]) and sulphur (45 kg S ha-1 year-1 [-29, 118]), a balanced phosphorus budget (0 kg P ha-1 year-1 [-2,2]), and a deficit for potassium (-12 kg K ha-1 year-1 [-21, -3]). We observed large differences between farms that could be partly explained by farm type and budgeting method. Arable and mixed farms showed lower nitrogen, phosphor, magnesium and sulphur budgets than dairy/beef farms or even vegetable farms, while all farm types besides dairy/ beef farms showed deficits for K budgets. Further, farm-gate budget studies yielded higher budgets than soil surface budgets. Variations between studied countries could also be detected, but the coverage and comparability is low due to differences in studied farm types and budgeting method.

Objectives: To implement a multi-year nation-wide programme, by the means of a personalised lifestyle intervention, to prevent or to delay cognitive decline that can contribute to development of dementia in Luxembourg. Methods: Participants with mild cognitive impairment, referred to the programme by their treating physician, undergo an extensive cognitive evaluation by a neuropsychologist on relevant neuropsychological domains as well as a structured dementia risk factor assessment. Based on these assessments, individualised lifestyle interventions are offered by diverse national partners involved in the programme, thus filling a gap of not yet reimbursed services in the Luxemburgish healthcare system. After the personalised lifestyle interventions, each participant will undergo a neuropsychological follow-up in order to re-evaluate his/her health status in terms of cognition. Results: We established a participant-centred national network by presenting the programme on many outreach events and efficient stakeholder communication. The network raises the awareness of dementia prevention in the Luxembourgish population, fosters interdisciplinary communication between individual medical and non-medical healthcare professionals and allows for a successful recruitment of the target population. Moreover, we collect information about adherence to the suggested lifestyle changes, as well as the effectiveness of our interventions in reducing risk factors contributing to the onset of dementia. Conclusions: We provide evidence for the feasibility of the implementation of a nation-wide dementia prevention programme including diverse partners offering personalised lifestyle interventions, which are easily transferrable to other countries. Future results from this programme may also help to integrate prevention interventions into the regular healthcare system.

Objectives: To implement a multi-year nation-wide programme, by the means of a personalised lifestyle intervention, to prevent or to delay cognitive decline that can contribute to development of dementia in Luxembourg. Methods: Participants with mild cognitive impairment, referred to the programme by their treating physician, undergo an extensive cognitive evaluation by a neuropsychologist on relevant neuropsychological domains as well as a structured dementia risk factor assessment. Based on these assessments, individualised lifestyle interventions are offered by diverse national partners involved in the programme, thus filling a gap of not yet reimbursed services in the Luxemburgish healthcare system. After the personalised lifestyle interventions, each participant will undergo a neuropsychological follow-up in order to re-evaluate his/her health status in terms of cognition. Results: We established a participant-centred national network by presenting the programme on many outreach events and efficient stakeholder communication. The network raises the awareness of dementia prevention in the Luxembourgish population, fosters interdisciplinary communication between individual medical and non-medical healthcare professionals and allows for a successful recruitment of the target population. Moreover, we collect information about adherence to the suggested lifestyle changes, as well as the effectiveness of our interventions in reducing risk factors contributing to the onset of dementia. Conclusions: We provide evidence for the feasibility of the implementation of a nation-wide dementia prevention programme including diverse partners offering personalised lifestyle interventions, which are easily transferrable to other countries. Future results from this programme may also help to integrate prevention interventions into the regular healthcare system.

Limited nutrient availability is one of the major challenges in organic farming. Little is known about nutrient budgets of organic farms, the underlying factors or effects on soil fertility. We therefore assessed farm gate nutrient budgets for nitrogen (N), phosphorus (P), potassium (K), magnesium (Mg) and sulfur (S) of 20 organic farms in Germany and analyzed their soil nutri-ent status. In average, the budgets showed a surplus of N (19 kg ha−1), K (5 kg ha−1), S (12 kg ha−1), and Mg (7 kg ha−1), and a deficit of P (−3 kg ha−1). There was, however, high variability between farms (e.g. standard deviation up to ± 36 kg N ha−1), which was mainly explained by different degrees of reliance on biological N fixation (BNF) as N source. When farms obtained more than 60% of their N input through BNF, they had deficits of P (mean −8 kg P ha−1) and K (mean −18 kg K ha−1). Nutrient status of most soils was within the ad-vised corridor, but for P, K and Mg, 10–15% of fields were lower and 45–63% were higher than advised. Extractable soil nutrient contents did not correlate with the nutrient budgets, inputs or outputs. Only extractable soil P increased with increasing P inputs and outputs. Fur-thermore, a decrease in extractable soil P was detected with a prolonged history of organic farming, indicating a risk of soil P mining in organic farming systems. In conclusion, the study revealed nutrient imbalances in organic farming and pointed to P and K scarcity as a major challenge for organic farms with high reliance on BNF in the long term.

Limited nutrient availability is one of the major challenges in organic farming. Little is known about nutrient budgets of organic farms, the underlying factors or effects on soil fertility. We therefore assessed farm gate nutrient budgets for nitrogen (N), phosphorus (P), potassium (K), magnesium (Mg) and sulfur (S) of 20 organic farms in Germany and analyzed their soil nutri-ent status. In average, the budgets showed a surplus of N (19 kg ha−1), K (5 kg ha−1), S (12 kg ha−1), and Mg (7 kg ha−1), and a deficit of P (−3 kg ha−1). There was, however, high variability between farms (e.g. standard deviation up to ± 36 kg N ha−1), which was mainly explained by different degrees of reliance on biological N fixation (BNF) as N source. When farms obtained more than 60% of their N input through BNF, they had deficits of P (mean −8 kg P ha−1) and K (mean −18 kg K ha−1). Nutrient status of most soils was within the ad-vised corridor, but for P, K and Mg, 10–15% of fields were lower and 45–63% were higher than advised. Extractable soil nutrient contents did not correlate with the nutrient budgets, inputs or outputs. Only extractable soil P increased with increasing P inputs and outputs. Fur-thermore, a decrease in extractable soil P was detected with a prolonged history of organic farming, indicating a risk of soil P mining in organic farming systems. In conclusion, the study revealed nutrient imbalances in organic farming and pointed to P and K scarcity as a major challenge for organic farms with high reliance on BNF in the long term.

Organic fertilisers for apple production are multi-nutrient fertilisers that may cause nutrient imbalances in the production system. We carried out investigations on new organic fertilisers to assess their suitability for apple cultivation with the goal of more balanced fertilisation. We compared biogas digestates, compost, peas, clover grass pellets and silage to commonly used horn grit, vinasse and an unfertilised control in 2018 and 2019 in an apple orchard near Lake Constance. No significant differences were detected with regard to fruit quality and yield. Highest values of mineral nitrogen in the soil could be seen in the digestates and the peas in May

Limited nutrient availability is one of the major challenges in organic farming. Little is known about nutrient budgets of organic farms, the underlying factors or effects on soil fertility. We therefore assessed farm gate nutrient budgets for nitrogen (N), phosphorus (P), potassium (K), magnesium (Mg) and sulfur (S) of 20 organic farms in Germany and analyzed their soil nutri-ent status. In average, the budgets showed a surplus of N (19 kg ha−1), K (5 kg ha−1), S (12 kg ha−1), and Mg (7 kg ha−1), and a deficit of P (−3 kg ha−1). There was, however, high variability between farms (e.g. standard deviation up to ± 36 kg N ha−1), which was mainly explained by different degrees of reliance on biological N fixation (BNF) as N source. When farms obtained more than 60% of their N input through BNF, they had deficits of P (mean −8 kg P ha−1) and K (mean −18 kg K ha−1). Nutrient status of most soils was within the ad-vised corridor, but for P, K and Mg, 10–15% of fields were lower and 45–63% were higher than advised. Extractable soil nutrient contents did not correlate with the nutrient budgets, inputs or outputs. Only extractable soil P increased with increasing P inputs and outputs. Fur-thermore, a decrease in extractable soil P was detected with a prolonged history of organic farming, indicating a risk of soil P mining in organic farming systems. In conclusion, the study revealed nutrient imbalances in organic farming and pointed to P and K scarcity as a major challenge for organic farms with high reliance on BNF in the long term.

Phosphorus (P) is an essential and limiting nutrient for agricultural systems, where the demand for agricultural products such as food, feed, and bio-fuel are the major drivers of the intensification of agricultural production systems. Globally, maize is one of three main cereal crops, a main feedstock for animal production and a substrate for the production of bio-ethanol. This study investigated P flows through the multiple utilization systems of maize (as represented by the subsystems of food, feed and energy production) at a crop level of 2016 as reference year and made future predictions of P flows for the year 2030 based on different scenarios for foodfeed-energy systems in China. For 2016, the subsystem of animal production resulted in the highest waste of P due to inappropriate manure management, but the subsystem of value-added products (Bio-fuel production, distillers dried grains with solubles (DDGS), maize-oil) showed the lowest P use efficiency (39%). From the value-added subsystem, 17% of P from the process flow to the subsystem of animal production as DDGS, and 61% of P is wasted associated with wastewater and sludge. Future scenarios of structural adjustments in the maize consumption system predict that the supply of maize for animal feed will be threatened if the policy of the Biofuel National Promotion before 2020 is fully implemented in China, as current maize production will not meet the future demand of food, feed and energy simultaneously. The results emphasized the use of P waste resources and better sludge management from a systems perspective. This also implied the importance of exploring coordinated development and integrated strategies for sustainable P flow management in multiple utilization systems.

Organic fertilisers for apple production are multi-nutrient fertilisers that may cause nutrient imbalances in the production system. We carried out investigations on new organic fertilisers to assess their suitability for apple cultivation with the goal of more balanced fertilisation. We compared biogas digestates, compost, peas, clover grass pellets and silage to commonly used horn grit, vinasse and an unfertilised control in 2018 and 2019 in an apple orchard near Lake Constance. No significant differences were detected with regard to fruit quality and yield. Highest values of mineral nitrogen in the soil could be seen in the digestates and the peas in May

Nutrient supply to organic farms is a highly discussed topic in Europe, due to the restricted availability of external fertilizer resources and the use of contentious inputs. To optimize the flow of nutrients throughout the organic farming system, it is firstly necessary to obtain valid data on the nutrient status of organic farms. Nutrient budgets are a valid tool to investigate the nutrient demand or surplus of a system. However, there is currently no comprehensive overview of nutrient budgets of European organic farms. We therefore carried out a meta-analysis on 56 individual studies that reported either farm-gate or soil-surface budgets. The analysis showed an imbalance between nutrients, a general surplus of nitrogen (45 kg N ha-1 year-1 [95%-confidence interval (CI): 30, 61]), magnesium (16 kg Mg ha-1 year-1 [-9, 40]) and sulphur (45 kg S ha-1 year-1 [-29, 118]), a balanced phosphorus budget (0 kg P ha-1 year-1 [-2,2]), and a deficit for potassium (-12 kg K ha-1 year-1 [-21, -3]). We observed large differences between farms that could be partly explained by farm type and budgeting method. Arable and mixed farms showed lower nitrogen, phosphor, magnesium and sulphur budgets than dairy/beef farms or even vegetable farms, while all farm types besides dairy/ beef farms showed deficits for K budgets. Further, farm-gate budget studies yielded higher budgets than soil surface budgets. Variations between studied countries could also be detected, but the coverage and comparability is low due to differences in studied farm types and budgeting method.

Nutrient supply to organic farms is a highly discussed topic in Europe, due to the restricted availability of external fertilizer resources and the use of contentious inputs. To optimize the flow of nutrients throughout the organic farming system, it is firstly necessary to obtain valid data on the nutrient status of organic farms. Nutrient budgets are a valid tool to investigate the nutrient demand or surplus of a system. However, there is currently no comprehensive overview of nutrient budgets of European organic farms. We therefore carried out a meta-analysis on 56 individual studies that reported either farm-gate or soil-surface budgets. The analysis showed an imbalance between nutrients, a general surplus of nitrogen (45 kg N ha-1 year-1 [95%-confidence interval (CI): 30, 61]), magnesium (16 kg Mg ha-1 year-1 [-9, 40]) and sulphur (45 kg S ha-1 year-1 [-29, 118]), a balanced phosphorus budget (0 kg P ha-1 year-1 [-2,2]), and a deficit for potassium (-12 kg K ha-1 year-1 [-21, -3]). We observed large differences between farms that could be partly explained by farm type and budgeting method. Arable and mixed farms showed lower nitrogen, phosphor, magnesium and sulphur budgets than dairy/beef farms or even vegetable farms, while all farm types besides dairy/ beef farms showed deficits for K budgets. Further, farm-gate budget studies yielded higher budgets than soil surface budgets. Variations between studied countries could also be detected, but the coverage and comparability is low due to differences in studied farm types and budgeting method.

Limited nutrient availability is one of the major challenges in organic farming. Little is known about nutrient budgets of organic farms, the underlying factors or effects on soil fertility. We therefore assessed farm gate nutrient budgets for nitrogen (N), phosphorus (P), potassium (K), magnesium (Mg) and sulfur (S) of 20 organic farms in Germany and analyzed their soil nutri-ent status. In average, the budgets showed a surplus of N (19 kg ha−1), K (5 kg ha−1), S (12 kg ha−1), and Mg (7 kg ha−1), and a deficit of P (−3 kg ha−1). There was, however, high variability between farms (e.g. standard deviation up to ± 36 kg N ha−1), which was mainly explained by different degrees of reliance on biological N fixation (BNF) as N source. When farms obtained more than 60% of their N input through BNF, they had deficits of P (mean −8 kg P ha−1) and K (mean −18 kg K ha−1). Nutrient status of most soils was within the ad-vised corridor, but for P, K and Mg, 10–15% of fields were lower and 45–63% were higher than advised. Extractable soil nutrient contents did not correlate with the nutrient budgets, inputs or outputs. Only extractable soil P increased with increasing P inputs and outputs. Fur-thermore, a decrease in extractable soil P was detected with a prolonged history of organic farming, indicating a risk of soil P mining in organic farming systems. In conclusion, the study revealed nutrient imbalances in organic farming and pointed to P and K scarcity as a major challenge for organic farms with high reliance on BNF in the long term.

Nutrient supply to organic farms is a highly discussed topic in Europe, due to the restricted availability of external fertilizer resources and the use of contentious inputs. To optimize the flow of nutrients throughout the organic farming system, it is firstly necessary to obtain valid data on the nutrient status of organic farms. Nutrient budgets are a valid tool to investigate the nutrient demand or surplus of a system. However, there is currently no comprehensive overview of nutrient budgets of European organic farms. We therefore carried out a meta-analysis on 56 individual studies that reported either farm-gate or soil-surface budgets. The analysis showed an imbalance between nutrients, a general surplus of nitrogen (45 kg N ha-1 year-1 [95%-confidence interval (CI): 30, 61]), magnesium (16 kg Mg ha-1 year-1 [-9, 40]) and sulphur (45 kg S ha-1 year-1 [-29, 118]), a balanced phosphorus budget (0 kg P ha-1 year-1 [-2,2]), and a deficit for potassium (-12 kg K ha-1 year-1 [-21, -3]). We observed large differences between farms that could be partly explained by farm type and budgeting method. Arable and mixed farms showed lower nitrogen, phosphor, magnesium and sulphur budgets than dairy/beef farms or even vegetable farms, while all farm types besides dairy/ beef farms showed deficits for K budgets. Further, farm-gate budget studies yielded higher budgets than soil surface budgets. Variations between studied countries could also be detected, but the coverage and comparability is low due to differences in studied farm types and budgeting method.

Nutrient supply to organic farms is a highly discussed topic in Europe, due to the restricted availability of external fertilizer resources and the use of contentious inputs. To optimize the flow of nutrients throughout the organic farming system, it is firstly necessary to obtain valid data on the nutrient status of organic farms. Nutrient budgets are a valid tool to investigate the nutrient demand or surplus of a system. However, there is currently no comprehensive overview of nutrient budgets of European organic farms. We therefore carried out a meta-analysis on 56 individual studies that reported either farm-gate or soil-surface budgets. The analysis showed an imbalance between nutrients, a general surplus of nitrogen (45 kg N ha-1 year-1 [95%-confidence interval (CI): 30, 61]), magnesium (16 kg Mg ha-1 year-1 [-9, 40]) and sulphur (45 kg S ha-1 year-1 [-29, 118]), a balanced phosphorus budget (0 kg P ha-1 year-1 [-2,2]), and a deficit for potassium (-12 kg K ha-1 year-1 [-21, -3]). We observed large differences between farms that could be partly explained by farm type and budgeting method. Arable and mixed farms showed lower nitrogen, phosphor, magnesium and sulphur budgets than dairy/beef farms or even vegetable farms, while all farm types besides dairy/ beef farms showed deficits for K budgets. Further, farm-gate budget studies yielded higher budgets than soil surface budgets. Variations between studied countries could also be detected, but the coverage and comparability is low due to differences in studied farm types and budgeting method.

Limited nutrient availability is one of the major challenges in organic farming. Little is known about nutrient budgets of organic farms, the underlying factors or effects on soil fertility. We therefore assessed farm gate nutrient budgets for nitrogen (N), phosphorus (P), potassium (K), magnesium (Mg) and sulfur (S) of 20 organic farms in Germany and analyzed their soil nutri-ent status. In average, the budgets showed a surplus of N (19 kg ha−1), K (5 kg ha−1), S (12 kg ha−1), and Mg (7 kg ha−1), and a deficit of P (−3 kg ha−1). There was, however, high variability between farms (e.g. standard deviation up to ± 36 kg N ha−1), which was mainly explained by different degrees of reliance on biological N fixation (BNF) as N source. When farms obtained more than 60% of their N input through BNF, they had deficits of P (mean −8 kg P ha−1) and K (mean −18 kg K ha−1). Nutrient status of most soils was within the ad-vised corridor, but for P, K and Mg, 10–15% of fields were lower and 45–63% were higher than advised. Extractable soil nutrient contents did not correlate with the nutrient budgets, inputs or outputs. Only extractable soil P increased with increasing P inputs and outputs. Fur-thermore, a decrease in extractable soil P was detected with a prolonged history of organic farming, indicating a risk of soil P mining in organic farming systems. In conclusion, the study revealed nutrient imbalances in organic farming and pointed to P and K scarcity as a major challenge for organic farms with high reliance on BNF in the long term.

Limited nutrient availability is one of the major challenges in organic farming. Little is known about nutrient budgets of organic farms, the underlying factors or effects on soil fertility. We therefore assessed farm gate nutrient budgets for nitrogen (N), phosphorus (P), potassium (K), magnesium (Mg) and sulfur (S) of 20 organic farms in Germany and analyzed their soil nutri-ent status. In average, the budgets showed a surplus of N (19 kg ha−1), K (5 kg ha−1), S (12 kg ha−1), and Mg (7 kg ha−1), and a deficit of P (−3 kg ha−1). There was, however, high variability between farms (e.g. standard deviation up to ± 36 kg N ha−1), which was mainly explained by different degrees of reliance on biological N fixation (BNF) as N source. When farms obtained more than 60% of their N input through BNF, they had deficits of P (mean −8 kg P ha−1) and K (mean −18 kg K ha−1). Nutrient status of most soils was within the ad-vised corridor, but for P, K and Mg, 10–15% of fields were lower and 45–63% were higher than advised. Extractable soil nutrient contents did not correlate with the nutrient budgets, inputs or outputs. Only extractable soil P increased with increasing P inputs and outputs. Fur-thermore, a decrease in extractable soil P was detected with a prolonged history of organic farming, indicating a risk of soil P mining in organic farming systems. In conclusion, the study revealed nutrient imbalances in organic farming and pointed to P and K scarcity as a major challenge for organic farms with high reliance on BNF in the long term.

© 2020 The Authors. Alzheimer's & Dementia published by Wiley Periodicals, Inc. on behalf of Alzheimer's Association Reducing the risk of dementia can halt the worldwide increase of affected people. The multifactorial and heterogeneous nature of late-onset dementia, including Alzheimer's disease (AD), indicates a potential impact of multidomain lifestyle interventions on risk reduction. The positive results of the landmark multidomain Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) support such an approach. The World-Wide FINGERS (WW-FINGERS), launched in 2017 and including over 25 countries, is the first global network of multidomain lifestyle intervention trials for dementia risk reduction and prevention. WW-FINGERS aims to adapt, test, and optimize the FINGER model to reduce risk across the spectrum of cognitive decline—from at-risk asymptomatic states to early symptomatic stages—in different geographical, cultural, and economic settings. WW-FINGERS aims to harmonize and adapt multidomain interventions across various countries and settings, to facilitate data sharing and analysis across studies, and to promote international joint initiatives to identify globally implementable and effective preventive strategies.

Nutrient supply to organic farms is a highly discussed topic in Europe, due to the restricted availability of external fertilizer resources and the use of contentious inputs. To optimize the flow of nutrients throughout the organic farming system, it is firstly necessary to obtain valid data on the nutrient status of organic farms. Nutrient budgets are a valid tool to investigate the nutrient demand or surplus of a system. However, there is currently no comprehensive overview of nutrient budgets of European organic farms. We therefore carried out a meta-analysis on 56 individual studies that reported either farm-gate or soil-surface budgets. The analysis showed an imbalance between nutrients, a general surplus of nitrogen (45 kg N ha-1 year-1 [95%-confidence interval (CI): 30, 61]), magnesium (16 kg Mg ha-1 year-1 [-9, 40]) and sulphur (45 kg S ha-1 year-1 [-29, 118]), a balanced phosphorus budget (0 kg P ha-1 year-1 [-2,2]), and a deficit for potassium (-12 kg K ha-1 year-1 [-21, -3]). We observed large differences between farms that could be partly explained by farm type and budgeting method. Arable and mixed farms showed lower nitrogen, phosphor, magnesium and sulphur budgets than dairy/beef farms or even vegetable farms, while all farm types besides dairy/ beef farms showed deficits for K budgets. Further, farm-gate budget studies yielded higher budgets than soil surface budgets. Variations between studied countries could also be detected, but the coverage and comparability is low due to differences in studied farm types and budgeting method.