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1. Modification of the Association Between Frequent Aspirin Use and Ovarian Cancer Risk: A Meta-Analysis Using Individual-Level Data From Two Ovarian Cancer Consortia.

Author: Hurwitz, Lauren M, Hurwitz, Lauren M, Townsend, Mary K, Jordan, Susan J, Patel, Alpa V, Teras, Lauren R, Lacey, James V, Doherty, Jennifer A, Harris, Holly R, Goodman, Marc T, Shvetsov, Yurii B, Modugno, Francesmary, Moysich, Kirsten B, Robien, Kim, Prizment, Anna, Schildkraut, Joellen M, Berchuck, Andrew, Fortner, Renée T, Chan, Andrew T, Wentzensen, Nicolas, Hartge, Patricia, Sandler, Dale P, O'Brien, Katie M, Anton-Culver, Hoda, Ziogas, Argyrios, Menon, Usha, Ramus, Susan J, Pearce, Celeste Leigh, Wu, Anna H, White, Emily, Peters, Ulrike, Webb, Penelope M, Tworoger, Shelley S, Trabert, Britton, Hurwitz, Lauren M, Hurwitz, Lauren M, Townsend, Mary K, Jordan, Susan J, Patel, Alpa V, Teras, Lauren R, Lacey, James V, Doherty, Jennifer A, Harris, Holly R, Goodman, Marc T, Shvetsov, Yurii B, Modugno, Francesmary, Moysich, Kirsten B, Robien, Kim, Prizment, Anna, Schildkraut, Joellen M, Berchuck, Andrew, Fortner, Renée T, Chan, Andrew T, Wentzensen, Nicolas, Hartge, Patricia, Sandler, Dale P, O'Brien, Katie M, Anton-Culver, Hoda, Ziogas, Argyrios, Menon, Usha, Ramus, Susan J, Pearce, Celeste Leigh, Wu, Anna H, White, Emily, Peters, Ulrike, Webb, Penelope M, Tworoger, Shelley S, and Trabert, Britton
Abstract: PurposeFrequent aspirin use has been associated with reduced ovarian cancer risk, but no study has comprehensively assessed for effect modification. We leveraged harmonized, individual-level data from 17 studies to examine the association between frequent aspirin use and ovarian cancer risk, overall and across subgroups of women with other ovarian cancer risk factors.MethodsNine cohort studies from the Ovarian Cancer Cohort Consortium (n = 2,600 cases) and eight case-control studies from the Ovarian Cancer Association Consortium (n = 5,726 cases) were included. We used Cox regression and logistic regression to assess study-specific associations between frequent aspirin use (≥ 6 days/week) and ovarian cancer risk and combined study-specific estimates using random-effects meta-analysis. We conducted analyses within subgroups defined by individual ovarian cancer risk factors (endometriosis, obesity, family history of breast/ovarian cancer, nulliparity, oral contraceptive use, and tubal ligation) and by number of risk factors (0, 1, and ≥ 2).ResultsOverall, frequent aspirin use was associated with a 13% reduction in ovarian cancer risk (95% CI, 6 to 20), with no significant heterogeneity by study design (P = .48) or histotype (P = .60). Although no association was observed among women with endometriosis, consistent risk reductions were observed among all other subgroups defined by ovarian cancer risk factors (relative risks ranging from 0.79 to 0.93, all P-heterogeneity > .05), including women with ≥ 2 risk factors (relative risk, 0.81; 95% CI, 0.73 to 0.90).ConclusionThis study, the largest to-date on aspirin use and ovarian cancer, provides evidence that frequent aspirin use is associated with lower ovarian cancer risk regardless of the presence of most other ovarian cancer risk factors. Risk reductions were also observed among women with multiple risk factors, providing proof of principle that chemoprevention programs with frequent aspirin use could target higher
Published: 2022

2. B-Cell NHL Subtype Risk Associated with Autoimmune Conditions and PRS

Author: Wang, Sophia S., Vajdic, Claire M., Linet, Martha S., Slager, Susan L., Voutsinas, Jenna, Nieters, Alexandra, Casabonne, Delphine, Cerhan, James R., Cozen, Wendy, Alarcón, Graciela, Martínez-Maza, Otoniel, Brown, Elizabeth E., Bracci, Paige M., Turner, Jennifer, Hjalgrim, Henrik, Bhatti, Parveen, Zhang, Yawei, Birmann, Brenda M., Flowers, Christopher R., Paltiel, Ora, Holly, Elizabeth A., Kane, Eleanor, Weisenburger, Dennis D., Maynadié, Marc, Cocco, Pierluigi, Foretova, Lenka, Breen, Elizabeth Crabb, Lan, Qing, Brooks-Wilson, Angela, De Roos, Anneclaire J., Smith, Martyn T., Roman, Eve, Boffetta, Paolo, Kricker, Anne, Zheng, Tongzhang, Skibola, Christine F., Clavel, Jacqueline, Monnereau, Alain, Chanock, Stephen J., Rothman, Nathaniel, Benavente, Yolanda, Hartge, Patricia, Smedby, Karin E., Wang, Sophia S., Vajdic, Claire M., Linet, Martha S., Slager, Susan L., Voutsinas, Jenna, Nieters, Alexandra, Casabonne, Delphine, Cerhan, James R., Cozen, Wendy, Alarcón, Graciela, Martínez-Maza, Otoniel, Brown, Elizabeth E., Bracci, Paige M., Turner, Jennifer, Hjalgrim, Henrik, Bhatti, Parveen, Zhang, Yawei, Birmann, Brenda M., Flowers, Christopher R., Paltiel, Ora, Holly, Elizabeth A., Kane, Eleanor, Weisenburger, Dennis D., Maynadié, Marc, Cocco, Pierluigi, Foretova, Lenka, Breen, Elizabeth Crabb, Lan, Qing, Brooks-Wilson, Angela, De Roos, Anneclaire J., Smith, Martyn T., Roman, Eve, Boffetta, Paolo, Kricker, Anne, Zheng, Tongzhang, Skibola, Christine F., Clavel, Jacqueline, Monnereau, Alain, Chanock, Stephen J., Rothman, Nathaniel, Benavente, Yolanda, Hartge, Patricia, and Smedby, Karin E.
Abstract: Background: A previous International Lymphoma Epidemiology (InterLymph) Consortium evaluation of joint associations between five immune gene variants and autoimmune conditions reported interactions between B-cell response-mediated autoimmune conditions and the rs1800629 genotype on risk of B-cell non–Hodgkin lymphoma (NHL) subtypes. Here, we extend that evaluation using NHL subtype-specific polygenic risk scores (PRS) constructed from loci identified in genome-wide association studies of three common B-cell NHL subtypes. Methods: In a pooled analysis of NHL cases and controls of Caucasian descent from 14 participating InterLymph studies, we evaluated joint associations between B-cell–mediated autoimmune conditions and tertile (T) of PRS for risk of diffuse large B-cell lymphoma (DLBCL; n ¼ 1,914), follicular lymphoma (n ¼ 1,733), and marginal zone lymphoma (MZL; n ¼ 407), using unconditional logistic regression. Results: We demonstrated a positive association of DLBCL PRS with DLBCL risk [T2 vs. T1: OR ¼ 1.24; 95% confidence interval (CI), 1.08–1.43; T3 vs. T1: OR ¼ 1.81; 95% CI, 1.59–2.07; P-trend (Ptrend) < 0.0001]. DLBCL risk also increased with increasing PRS tertile among those with an autoimmune condition, being highest for those with a B-cell–mediated autoimmune condition and a T3 PRS [OR ¼ 6.46 vs. no autoimmune condition and a T1 PRS, Ptrend < 0.0001, P-interaction (Pinteraction) ¼ 0.49]. Follicular lymphoma and MZL risk demonstrated no evidence of joint associations or significant Pinteraction. Conclusions: Our results suggest that PRS constructed from currently known subtype-specific loci may not necessarily capture biological pathways shared with autoimmune conditions. Impact: Targeted genetic (PRS) screening among population subsets with autoimmune conditions may offer opportunities for identifying those at highest risk for (and early detection from) DLBCL.
Published: 2022

3. B-Cell NHL Subtype Risk Associated with Autoimmune Conditions and PRS

Author: Wang, Sophia S., Vajdic, Claire M., Linet, Martha S., Slager, Susan L., Voutsinas, Jenna, Nieters, Alexandra, Casabonne, Delphine, Cerhan, James R., Cozen, Wendy, Alarcón, Graciela, Martínez-Maza, Otoniel, Brown, Elizabeth E., Bracci, Paige M., Turner, Jennifer, Hjalgrim, Henrik, Bhatti, Parveen, Zhang, Yawei, Birmann, Brenda M., Flowers, Christopher R., Paltiel, Ora, Holly, Elizabeth A., Kane, Eleanor, Weisenburger, Dennis D., Maynadié, Marc, Cocco, Pierluigi, Foretova, Lenka, Breen, Elizabeth Crabb, Lan, Qing, Brooks-Wilson, Angela, De Roos, Anneclaire J., Smith, Martyn T., Roman, Eve, Boffetta, Paolo, Kricker, Anne, Zheng, Tongzhang, Skibola, Christine F., Clavel, Jacqueline, Monnereau, Alain, Chanock, Stephen J., Rothman, Nathaniel, Benavente, Yolanda, Hartge, Patricia, Smedby, Karin E., Wang, Sophia S., Vajdic, Claire M., Linet, Martha S., Slager, Susan L., Voutsinas, Jenna, Nieters, Alexandra, Casabonne, Delphine, Cerhan, James R., Cozen, Wendy, Alarcón, Graciela, Martínez-Maza, Otoniel, Brown, Elizabeth E., Bracci, Paige M., Turner, Jennifer, Hjalgrim, Henrik, Bhatti, Parveen, Zhang, Yawei, Birmann, Brenda M., Flowers, Christopher R., Paltiel, Ora, Holly, Elizabeth A., Kane, Eleanor, Weisenburger, Dennis D., Maynadié, Marc, Cocco, Pierluigi, Foretova, Lenka, Breen, Elizabeth Crabb, Lan, Qing, Brooks-Wilson, Angela, De Roos, Anneclaire J., Smith, Martyn T., Roman, Eve, Boffetta, Paolo, Kricker, Anne, Zheng, Tongzhang, Skibola, Christine F., Clavel, Jacqueline, Monnereau, Alain, Chanock, Stephen J., Rothman, Nathaniel, Benavente, Yolanda, Hartge, Patricia, and Smedby, Karin E.
Abstract: Background: A previous International Lymphoma Epidemiology (InterLymph) Consortium evaluation of joint associations between five immune gene variants and autoimmune conditions reported interactions between B-cell response-mediated autoimmune conditions and the rs1800629 genotype on risk of B-cell non–Hodgkin lymphoma (NHL) subtypes. Here, we extend that evaluation using NHL subtype-specific polygenic risk scores (PRS) constructed from loci identified in genome-wide association studies of three common B-cell NHL subtypes. Methods: In a pooled analysis of NHL cases and controls of Caucasian descent from 14 participating InterLymph studies, we evaluated joint associations between B-cell–mediated autoimmune conditions and tertile (T) of PRS for risk of diffuse large B-cell lymphoma (DLBCL; n ¼ 1,914), follicular lymphoma (n ¼ 1,733), and marginal zone lymphoma (MZL; n ¼ 407), using unconditional logistic regression. Results: We demonstrated a positive association of DLBCL PRS with DLBCL risk [T2 vs. T1: OR ¼ 1.24; 95% confidence interval (CI), 1.08–1.43; T3 vs. T1: OR ¼ 1.81; 95% CI, 1.59–2.07; P-trend (Ptrend) < 0.0001]. DLBCL risk also increased with increasing PRS tertile among those with an autoimmune condition, being highest for those with a B-cell–mediated autoimmune condition and a T3 PRS [OR ¼ 6.46 vs. no autoimmune condition and a T1 PRS, Ptrend < 0.0001, P-interaction (Pinteraction) ¼ 0.49]. Follicular lymphoma and MZL risk demonstrated no evidence of joint associations or significant Pinteraction. Conclusions: Our results suggest that PRS constructed from currently known subtype-specific loci may not necessarily capture biological pathways shared with autoimmune conditions. Impact: Targeted genetic (PRS) screening among population subsets with autoimmune conditions may offer opportunities for identifying those at highest risk for (and early detection from) DLBCL.
Published: 2022

4. Smoking Modifies Pancreatic Cancer Risk Loci on 2q21.3

Author: Mocci, Evelina, Kundu, Prosenjit, Wheeler, William, Arslan, Alan A., Beane-Freeman, Laura E., Bracci, Paige M., Brennan, Paul, Canzian, Federico, Du, Mengmeng, Gallinger, Steven, Giles, Graham G., Goodman, Phyllis J., Kooperberg, Charles, Le Marchand, Loic, Neale, Rachel E., Shu, Xiao-Ou, Visvanathan, Kala, White, Emily, Zheng, Wei, Albanes, Demetrius, Andreotti, Gabriella, Babic, Ana, Bamlet, William R., Berndt, Sonja, Blackford, Amanda L., Bueno-de-Mesquita, Bas, Buring, Julie E., Campa, Daniele, Chanock, Stephen J., Childs, Erica J., Duell, Eric J., Fuchs, Charles S., Gaziano, J. Michael, Giovannucci, Edward L., Goggins, Michael G., Hartge, Patricia, Hassan, Manal M., Holly, Elizabeth A., Hoover, Robert N., Hung, Rayjean J., Kurtz, Robert C., Lee, I-Min, Malats, Nuria, Milne, Roger L., Ng, Kimmie, Oberg, Ann L., Panico, Salvatore, Peters, Ulrike, Porta, Miquel, Rabe, Kari G., Riboli, Elio, Rothman, Nathaniel, Scelo, Ghislaine, Sesso, Howard D., Silverman, Debra T., Stevens, Victoria L., Strobel, Oliver, Thompson, Ian M., Tjonneland, Anne, Trichopoulou, Antonia, Van den Eeden, Stephen K., Wactawski-Wende, Jean, Wentzensen, Nicolas, Wilkens, Lynne R., Yu, Herbert, Yuan, Fangcheng, Zeleniuch-Jacquotte, Anne, Amundadottir, Laufey T., Li, Donghui, Jacobs, Eric J., Petersen, Gloria M., Wolpin, Brian M., Risch, Harvey A., Kraft, Peter, Chatterjee, Nilanjan, Klein, Alison P., Stolzenberg-Solomon, Rachael, Mocci, Evelina, Kundu, Prosenjit, Wheeler, William, Arslan, Alan A., Beane-Freeman, Laura E., Bracci, Paige M., Brennan, Paul, Canzian, Federico, Du, Mengmeng, Gallinger, Steven, Giles, Graham G., Goodman, Phyllis J., Kooperberg, Charles, Le Marchand, Loic, Neale, Rachel E., Shu, Xiao-Ou, Visvanathan, Kala, White, Emily, Zheng, Wei, Albanes, Demetrius, Andreotti, Gabriella, Babic, Ana, Bamlet, William R., Berndt, Sonja, Blackford, Amanda L., Bueno-de-Mesquita, Bas, Buring, Julie E., Campa, Daniele, Chanock, Stephen J., Childs, Erica J., Duell, Eric J., Fuchs, Charles S., Gaziano, J. Michael, Giovannucci, Edward L., Goggins, Michael G., Hartge, Patricia, Hassan, Manal M., Holly, Elizabeth A., Hoover, Robert N., Hung, Rayjean J., Kurtz, Robert C., Lee, I-Min, Malats, Nuria, Milne, Roger L., Ng, Kimmie, Oberg, Ann L., Panico, Salvatore, Peters, Ulrike, Porta, Miquel, Rabe, Kari G., Riboli, Elio, Rothman, Nathaniel, Scelo, Ghislaine, Sesso, Howard D., Silverman, Debra T., Stevens, Victoria L., Strobel, Oliver, Thompson, Ian M., Tjonneland, Anne, Trichopoulou, Antonia, Van den Eeden, Stephen K., Wactawski-Wende, Jean, Wentzensen, Nicolas, Wilkens, Lynne R., Yu, Herbert, Yuan, Fangcheng, Zeleniuch-Jacquotte, Anne, Amundadottir, Laufey T., Li, Donghui, Jacobs, Eric J., Petersen, Gloria M., Wolpin, Brian M., Risch, Harvey A., Kraft, Peter, Chatterjee, Nilanjan, Klein, Alison P., and Stolzenberg-Solomon, Rachael
Abstract: Germline variation and smoking are independently associated with pancreatic ductal adenocarcinoma (PDAC). We conducted genome-wide smoking interaction analysis of PDAC using genotype data from four previous genome-wide association studies in individuals of European ancestry (7,937 cases and 11,774 controls). Examination of expression quantitative trait loci data from the Genotype-Tissue Expression Project followed by colocalization analysis was conducted to determine whether there was support for common SNP(s) underlying the observed associations. Statistical tests were two sided and P < 5 similar to 10(-8) was considered statistically significant. Genome-wide significant evidence of qualitative interaction was identified on chr2q21.3 in intron 5 of the transmembrane protein 163 (TMEM163) and upstream of the cyclin T2 (CCNT2). The most significant SNP using the Empirical Bayes method, in this region that included 45 significantly associated SNPs, was rs1818613 [per allele OR in never smokers 0.87, 95% confidence interval (CI), 0.82-0.93; former smokers 1.00, 95% CI, 0.91-1.07; current smokers 1.25, 95% CI 1.12-1.40, P-interaction = 3.08 x 10(-9)). Examination of the Genotype-Tissue Expression Project data demonstrated an expression quantitative trait locus in this region for TMEM163 and CCNT2 in several tissue types. Colocalization analysis supported a shared SNP, rs842357, in high linkage disequilibrium with rs1818613 (r(2) = 0. 94) driving both the observed interaction and the expression quantitative trait loci signals. Future studies are needed to confirm and understand the differential biologic mechanisms by smoking status that contribute to our PDAC findings.Significance: This large genome-wide interaction study identifies a susceptibility locus on 2q21.3 that significantly modified PDAC risk by smoking status, providing insight into smoking-associated PDAC, with implications for prevention.
Published: 2021

5. Associations between reproductive factors and biliary tract cancers in women from the Biliary Tract Cancers Pooling Project

Author: Jackson, Sarah S., Adami, Hans-Olov, Andreotti, Gabriella, Beane-Freeman, Laura E., de Gonzalez, Amy Berrington, Buring, Julie E., Fraser, Gary E., Freedman, Neal D., Gapstur, Susan M., Gierach, Gretchen, Giles, Graham G., Grodstein, Francine, Hartge, Patricia, Jenab, Mazda, Kirsh, Victoria, Knutsen, Synnove F., Lan, Qing, Larsson, Susanna C., Lee, I-Min, Lee, Mei-Hsuan, Liao, Linda M., Milne, Roger L., Monroe, Kristine R., Neuhouser, Marian L., O'Brien, Katie M., Petrick, Jessica L., Purdue, Mark P., Rohan, Thomas E., Sandin, Sven, Sandler, Dale P., Sawada, Norie, Shadyab, Aladdin H., Simon, Tracey G., Sinha, Rashmi, Stolzenberg-Solomon, Rachael, Tsugane, Shoichiro, Weiderpass, Elisabete, Wolk, Alicja, Yang, Hwai-, I, Zheng, Wei, McGlynn, Katherine A., Campbell, Peter T., Koshiol, Jill, Jackson, Sarah S., Adami, Hans-Olov, Andreotti, Gabriella, Beane-Freeman, Laura E., de Gonzalez, Amy Berrington, Buring, Julie E., Fraser, Gary E., Freedman, Neal D., Gapstur, Susan M., Gierach, Gretchen, Giles, Graham G., Grodstein, Francine, Hartge, Patricia, Jenab, Mazda, Kirsh, Victoria, Knutsen, Synnove F., Lan, Qing, Larsson, Susanna C., Lee, I-Min, Lee, Mei-Hsuan, Liao, Linda M., Milne, Roger L., Monroe, Kristine R., Neuhouser, Marian L., O'Brien, Katie M., Petrick, Jessica L., Purdue, Mark P., Rohan, Thomas E., Sandin, Sven, Sandler, Dale P., Sawada, Norie, Shadyab, Aladdin H., Simon, Tracey G., Sinha, Rashmi, Stolzenberg-Solomon, Rachael, Tsugane, Shoichiro, Weiderpass, Elisabete, Wolk, Alicja, Yang, Hwai-, I, Zheng, Wei, McGlynn, Katherine A., Campbell, Peter T., and Koshiol, Jill
Abstract: Background & Aims: Gallbladder cancer (GBC) is known to have a female predominance while other biliary tract cancers (BTCs) have a male predominance. However, the role of female reproductive factors in BTC etiology remains unclear. Methods: We pooled data from 19 studies of >1.5 million women participating in the Biliary Tract Cancers Pooling Project to examine the associations of parity, age at menarche, reproductive years, and age at menopause with BTC. Associations for age at menarche and reproductive years with BTC were analyzed separately for Asian and non-Asian women. Hazard ratios (HRs) and 95% CIs were estimated using Cox proportional hazards models, stratified by study. Results: During 21,681,798 person-years of follow-up, 875 cases of GBC, 379 of intrahepatic bile duct cancer (IHBDC), 450 of extrahepatic bile duct cancer (EHBDC), and 261 of ampulla of Vater cancer (AVC) occurred. High parity was associated with risk of GBC (HR >= 5 vs. 0 births 1.72; 95% CI 1.25-2.38). Age at menarche (HR per year increase 1.15; 95% CI 1.06-1.24) was associated with GBC risk in Asian women while reproductive years were associated with GBC risk (HR per 5 years 1.13; 95% CI 1.04-1.22) in non-Asian women. Later age at menarche was associated with IHBDC (HR 1.19; 95% CI 1.09-1.31) and EHBDC (HR 1.11; 95% CI 1.01-1.22) in Asian women only. Conclusion: We observed an increased risk of GBC with increasing parity. Among Asian women, older age at menarche was associated with increased risk for GBC, IHBDC, and EHBDC, while increasing reproductive years was associated with GBC in non-Asian women. These results suggest that sex hormones have distinct effects on cancers across the biliary tract that vary by geography. Lay summary: Our findings show that the risk of gallbladder cancer is increased among women who have given birth (especially women with 5 or more children). In women from Asian countries, later age at menarche increases the risk of gallbladder cancer, intrahepat
Published: 2020
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6. The Risk of Ovarian Cancer Increases with an Increase in the Lifetime Number of Ovulatory Cycles : An Analysis from the Ovarian Cancer Cohort Consortium (OC3)

Author: Trabert, Britton, Tworoger, Shelley S., O'Brien, Katie M., Townsend, Mary K., Fortner, Renee T., Iversen, Edwin S., Hartge, Patricia, White, Emily, Amiano, Pilar, Arslan, Alan A., Bernstein, Leslie, Brinton, Louise A., Buring, Julie E., Dossus, Laure, Fraser, Gary E., Gaudet, Mia M., Giles, Graham G., Gram, Inger T., Harris, Holly R., Bolton, Judith Hoffman, Idahl, Annika, Jones, Michael E., Kaaks, Rudolf, Kirsh, Victoria A., Knutsen, Synnove F., Kvaskoff, Marina, Lacey, James, V, Lee, I-Min, Milne, Roger L., Onland-Moret, N. Charlotte, Overvad, Kim, Patel, Alpa, V, Peters, Ulrike, Poynter, Jenny N., Riboli, Elio, Robien, Kim, Rohan, Thomas E., Sandler, Dale P., Schairer, Catherine, Schouten, Leo J., Setiawan, Veronica W., Swerdlow, Anthony J., Travis, Ruth C., Trichopoulou, Antonia, van den Brandt, Piet A., Visvanathan, Kala, Wilkens, Lynne R., Wolk, Alicja, Zeleniuch-Jacquotte, Anne, Wentzensen, Nicolas, Trabert, Britton, Tworoger, Shelley S., O'Brien, Katie M., Townsend, Mary K., Fortner, Renee T., Iversen, Edwin S., Hartge, Patricia, White, Emily, Amiano, Pilar, Arslan, Alan A., Bernstein, Leslie, Brinton, Louise A., Buring, Julie E., Dossus, Laure, Fraser, Gary E., Gaudet, Mia M., Giles, Graham G., Gram, Inger T., Harris, Holly R., Bolton, Judith Hoffman, Idahl, Annika, Jones, Michael E., Kaaks, Rudolf, Kirsh, Victoria A., Knutsen, Synnove F., Kvaskoff, Marina, Lacey, James, V, Lee, I-Min, Milne, Roger L., Onland-Moret, N. Charlotte, Overvad, Kim, Patel, Alpa, V, Peters, Ulrike, Poynter, Jenny N., Riboli, Elio, Robien, Kim, Rohan, Thomas E., Sandler, Dale P., Schairer, Catherine, Schouten, Leo J., Setiawan, Veronica W., Swerdlow, Anthony J., Travis, Ruth C., Trichopoulou, Antonia, van den Brandt, Piet A., Visvanathan, Kala, Wilkens, Lynne R., Wolk, Alicja, Zeleniuch-Jacquotte, Anne, and Wentzensen, Nicolas
Abstract: Repeated exposure to the acute proinflammatory environment that follows ovulation at the ovarian surface and distal fallopian tube over a woman's reproductive years may increase ovarian cancer risk. To address this, analyses included individual-level data from 558,709 naturally menopausal women across 20 prospective cohorts, among whom 3,246 developed invasive epithelial ovarian cancer (2,045 serous, 319 endometrioid, 184 mucinous, 121 clear cell, 577 other/unknown). Cox models were used to estimate multivariable-adjusted HRs between lifetime ovulatory cycles (LOC) and its components and ovarian cancer risk overall and by histotype. Women in the 90th percentile of LOC (>514 cycles) were almost twice as likely to be diagnosed with ovarian cancer than women in the 10th percentile (<294) [HR (95% confidence interval): 1.92 (1.60-2.30)]. Risk increased 14% per 5-year increase in LOC (60 cycles) [(1.10-1.17)]; this association remained after adjustment for LOC components: number of pregnancies and oral contraceptive use [1.08 (1.04-1.12)]. The association varied by histotype, with increased risk of serous [1.13 (1.09-1.17)], endometrioid [1.20 (1.10-1.32)], and clear cell [1.37 (1.18-1.58)], but not mucinous [0.99 (0.88-1.10), P-heterogeneity = 0.01] tumors. Heterogeneity across histotypes was reduced [P-heterogeneity = 0.15] with adjustment for LOC components [1.08 serous, 1.11 endometrioid, 1.26 clear cell, 0.94 mucinous]. Although the 10-year absolute risk of ovarian cancer is small, it roughly doubles as the number of LOC rises from approximately 300 to 500. The consistency and linearity of effects strongly support the hypothesis that each ovulation leads to small increases in the risk of most ovarian cancers, a risk that cumulates through life, suggesting this as an important area for identifying intervention strategies.
Published: 2020
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7. The Risk of Ovarian Cancer Increases with an Increase in the Lifetime Number of Ovulatory Cycles : An Analysis from the Ovarian Cancer Cohort Consortium (OC3)

Author: Trabert, Britton, Tworoger, Shelley S., O'Brien, Katie M., Townsend, Mary K., Fortner, Renee T., Iversen, Edwin S., Hartge, Patricia, White, Emily, Amiano, Pilar, Arslan, Alan A., Bernstein, Leslie, Brinton, Louise A., Buring, Julie E., Dossus, Laure, Fraser, Gary E., Gaudet, Mia M., Giles, Graham G., Gram, Inger T., Harris, Holly R., Bolton, Judith Hoffman, Idahl, Annika, Jones, Michael E., Kaaks, Rudolf, Kirsh, Victoria A., Knutsen, Synnove F., Kvaskoff, Marina, Lacey, James, V, Lee, I-Min, Milne, Roger L., Onland-Moret, N. Charlotte, Overvad, Kim, Patel, Alpa, V, Peters, Ulrike, Poynter, Jenny N., Riboli, Elio, Robien, Kim, Rohan, Thomas E., Sandler, Dale P., Schairer, Catherine, Schouten, Leo J., Setiawan, Veronica W., Swerdlow, Anthony J., Travis, Ruth C., Trichopoulou, Antonia, van den Brandt, Piet A., Visvanathan, Kala, Wilkens, Lynne R., Wolk, Alicja, Zeleniuch-Jacquotte, Anne, Wentzensen, Nicolas, Trabert, Britton, Tworoger, Shelley S., O'Brien, Katie M., Townsend, Mary K., Fortner, Renee T., Iversen, Edwin S., Hartge, Patricia, White, Emily, Amiano, Pilar, Arslan, Alan A., Bernstein, Leslie, Brinton, Louise A., Buring, Julie E., Dossus, Laure, Fraser, Gary E., Gaudet, Mia M., Giles, Graham G., Gram, Inger T., Harris, Holly R., Bolton, Judith Hoffman, Idahl, Annika, Jones, Michael E., Kaaks, Rudolf, Kirsh, Victoria A., Knutsen, Synnove F., Kvaskoff, Marina, Lacey, James, V, Lee, I-Min, Milne, Roger L., Onland-Moret, N. Charlotte, Overvad, Kim, Patel, Alpa, V, Peters, Ulrike, Poynter, Jenny N., Riboli, Elio, Robien, Kim, Rohan, Thomas E., Sandler, Dale P., Schairer, Catherine, Schouten, Leo J., Setiawan, Veronica W., Swerdlow, Anthony J., Travis, Ruth C., Trichopoulou, Antonia, van den Brandt, Piet A., Visvanathan, Kala, Wilkens, Lynne R., Wolk, Alicja, Zeleniuch-Jacquotte, Anne, and Wentzensen, Nicolas
Abstract: Repeated exposure to the acute proinflammatory environment that follows ovulation at the ovarian surface and distal fallopian tube over a woman's reproductive years may increase ovarian cancer risk. To address this, analyses included individual-level data from 558,709 naturally menopausal women across 20 prospective cohorts, among whom 3,246 developed invasive epithelial ovarian cancer (2,045 serous, 319 endometrioid, 184 mucinous, 121 clear cell, 577 other/unknown). Cox models were used to estimate multivariable-adjusted HRs between lifetime ovulatory cycles (LOC) and its components and ovarian cancer risk overall and by histotype. Women in the 90th percentile of LOC (>514 cycles) were almost twice as likely to be diagnosed with ovarian cancer than women in the 10th percentile (<294) [HR (95% confidence interval): 1.92 (1.60–2.30)]. Risk increased 14% per 5-year increase in LOC (60 cycles) [(1.10–1.17)]; this association remained after adjustment for LOC components: number of pregnancies and oral contraceptive use [1.08 (1.04–1.12)]. The association varied by histotype, with increased risk of serous [1.13 (1.09–1.17)], endometrioid [1.20 (1.10–1.32)], and clear cell [1.37 (1.18–1.58)], but not mucinous [0.99 (0.88–1.10), P-heterogeneity = 0.01] tumors. Heterogeneity across histotypes was reduced [P-heterogeneity = 0.15] with adjustment for LOC components [1.08 serous, 1.11 endometrioid, 1.26 clear cell, 0.94 mucinous]. Although the 10-year absolute risk of ovarian cancer is small, it roughly doubles as the number of LOC rises from approximately 300 to 500. The consistency and linearity of effects strongly support the hypothesis that each ovulation leads to small increases in the risk of most ovarian cancers, a risk that cumulates through life, suggesting this as an important area for identifying intervention strategies. Significance: Although ovarian cancer is rare, risk of most ovarian cancers doubles as the number of lifetime ovulatory cycles increases from
Published: 2020
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8. The risk of ovarian cancer increases with an increase in the lifetime number of ovulatory cycles : an analysis from the Ovarian Cancer Cohort Consortium (OC3)

Author: Trabert, Britton, Tworoger, Shelley S, O'Brien, Katie M, Townsend, Mary K, Fortner, Renée T, Iversen, Edwin S, Hartge, Patricia, White, Emily, Amiano, Pilar, Arslan, Alan A, Bernstein, Leslie, Brinton, Louise A, Buring, Julie E, Dossus, Laure, Fraser, Gary E, Gaudet, Mia M, Giles, Graham G, Gram, Inger T, Harris, Holly R, Hoffman Bolton, Judith, Idahl, Annika, Jones, Michael E, Kaaks, Rudolf, Kirsh, Victoria A, Knutsen, Synnove F, Kvaskoff, Marina, Lacey, James V, Lee, I-Min, Milne, Roger L, Onland-Moret, N Charlotte, Overvad, Kim, Patel, Alpa V, Peters, Ulrike, Poynter, Jenny N, Riboli, Elio, Robien, Kim, Rohan, Thomas E, Sandler, Dale P, Schairer, Catherine, Schouten, Leo J, Setiawan, Veronica Wendy, Swerdlow, Anthony J, Travis, Ruth C, Trichopoulou, Antonia, van den Brandt, Piet A, Visvanathan, Kala, Wilkens, Lynne R, Wolk, Alicja, Zeleniuch-Jacquotte, Anne, Wentzensen, Nicolas, Trabert, Britton, Tworoger, Shelley S, O'Brien, Katie M, Townsend, Mary K, Fortner, Renée T, Iversen, Edwin S, Hartge, Patricia, White, Emily, Amiano, Pilar, Arslan, Alan A, Bernstein, Leslie, Brinton, Louise A, Buring, Julie E, Dossus, Laure, Fraser, Gary E, Gaudet, Mia M, Giles, Graham G, Gram, Inger T, Harris, Holly R, Hoffman Bolton, Judith, Idahl, Annika, Jones, Michael E, Kaaks, Rudolf, Kirsh, Victoria A, Knutsen, Synnove F, Kvaskoff, Marina, Lacey, James V, Lee, I-Min, Milne, Roger L, Onland-Moret, N Charlotte, Overvad, Kim, Patel, Alpa V, Peters, Ulrike, Poynter, Jenny N, Riboli, Elio, Robien, Kim, Rohan, Thomas E, Sandler, Dale P, Schairer, Catherine, Schouten, Leo J, Setiawan, Veronica Wendy, Swerdlow, Anthony J, Travis, Ruth C, Trichopoulou, Antonia, van den Brandt, Piet A, Visvanathan, Kala, Wilkens, Lynne R, Wolk, Alicja, Zeleniuch-Jacquotte, Anne, and Wentzensen, Nicolas
Published: 2020

9. The risk of ovarian cancer increases with an increase in the lifetime number of ovulatory cycles : an analysis from the Ovarian Cancer Cohort Consortium (OC3)

Author: Trabert, Britton, Tworoger, Shelley S, O'Brien, Katie M, Townsend, Mary K, Fortner, Renée T, Iversen, Edwin S, Hartge, Patricia, White, Emily, Amiano, Pilar, Arslan, Alan A, Bernstein, Leslie, Brinton, Louise A, Buring, Julie E, Dossus, Laure, Fraser, Gary E, Gaudet, Mia M, Giles, Graham G, Gram, Inger T, Harris, Holly R, Hoffman Bolton, Judith, Idahl, Annika, Jones, Michael E, Kaaks, Rudolf, Kirsh, Victoria A, Knutsen, Synnove F, Kvaskoff, Marina, Lacey, James V, Lee, I-Min, Milne, Roger L, Onland-Moret, N Charlotte, Overvad, Kim, Patel, Alpa V, Peters, Ulrike, Poynter, Jenny N, Riboli, Elio, Robien, Kim, Rohan, Thomas E, Sandler, Dale P, Schairer, Catherine, Schouten, Leo J, Setiawan, Veronica Wendy, Swerdlow, Anthony J, Travis, Ruth C, Trichopoulou, Antonia, van den Brandt, Piet A, Visvanathan, Kala, Wilkens, Lynne R, Wolk, Alicja, Zeleniuch-Jacquotte, Anne, Wentzensen, Nicolas, Trabert, Britton, Tworoger, Shelley S, O'Brien, Katie M, Townsend, Mary K, Fortner, Renée T, Iversen, Edwin S, Hartge, Patricia, White, Emily, Amiano, Pilar, Arslan, Alan A, Bernstein, Leslie, Brinton, Louise A, Buring, Julie E, Dossus, Laure, Fraser, Gary E, Gaudet, Mia M, Giles, Graham G, Gram, Inger T, Harris, Holly R, Hoffman Bolton, Judith, Idahl, Annika, Jones, Michael E, Kaaks, Rudolf, Kirsh, Victoria A, Knutsen, Synnove F, Kvaskoff, Marina, Lacey, James V, Lee, I-Min, Milne, Roger L, Onland-Moret, N Charlotte, Overvad, Kim, Patel, Alpa V, Peters, Ulrike, Poynter, Jenny N, Riboli, Elio, Robien, Kim, Rohan, Thomas E, Sandler, Dale P, Schairer, Catherine, Schouten, Leo J, Setiawan, Veronica Wendy, Swerdlow, Anthony J, Travis, Ruth C, Trichopoulou, Antonia, van den Brandt, Piet A, Visvanathan, Kala, Wilkens, Lynne R, Wolk, Alicja, Zeleniuch-Jacquotte, Anne, and Wentzensen, Nicolas
Published: 2020

10. The risk of ovarian cancer increases with an increase in the lifetime number of ovulatory cycles : an analysis from the Ovarian Cancer Cohort Consortium (OC3)

Author: Trabert, Britton, Tworoger, Shelley S, O'Brien, Katie M, Townsend, Mary K, Fortner, Renée T, Iversen, Edwin S, Hartge, Patricia, White, Emily, Amiano, Pilar, Arslan, Alan A, Bernstein, Leslie, Brinton, Louise A, Buring, Julie E, Dossus, Laure, Fraser, Gary E, Gaudet, Mia M, Giles, Graham G, Gram, Inger T, Harris, Holly R, Hoffman Bolton, Judith, Idahl, Annika, Jones, Michael E, Kaaks, Rudolf, Kirsh, Victoria A, Knutsen, Synnove F, Kvaskoff, Marina, Lacey, James V, Lee, I-Min, Milne, Roger L, Onland-Moret, N Charlotte, Overvad, Kim, Patel, Alpa V, Peters, Ulrike, Poynter, Jenny N, Riboli, Elio, Robien, Kim, Rohan, Thomas E, Sandler, Dale P, Schairer, Catherine, Schouten, Leo J, Setiawan, Veronica Wendy, Swerdlow, Anthony J, Travis, Ruth C, Trichopoulou, Antonia, van den Brandt, Piet A, Visvanathan, Kala, Wilkens, Lynne R, Wolk, Alicja, Zeleniuch-Jacquotte, Anne, Wentzensen, Nicolas, Trabert, Britton, Tworoger, Shelley S, O'Brien, Katie M, Townsend, Mary K, Fortner, Renée T, Iversen, Edwin S, Hartge, Patricia, White, Emily, Amiano, Pilar, Arslan, Alan A, Bernstein, Leslie, Brinton, Louise A, Buring, Julie E, Dossus, Laure, Fraser, Gary E, Gaudet, Mia M, Giles, Graham G, Gram, Inger T, Harris, Holly R, Hoffman Bolton, Judith, Idahl, Annika, Jones, Michael E, Kaaks, Rudolf, Kirsh, Victoria A, Knutsen, Synnove F, Kvaskoff, Marina, Lacey, James V, Lee, I-Min, Milne, Roger L, Onland-Moret, N Charlotte, Overvad, Kim, Patel, Alpa V, Peters, Ulrike, Poynter, Jenny N, Riboli, Elio, Robien, Kim, Rohan, Thomas E, Sandler, Dale P, Schairer, Catherine, Schouten, Leo J, Setiawan, Veronica Wendy, Swerdlow, Anthony J, Travis, Ruth C, Trichopoulou, Antonia, van den Brandt, Piet A, Visvanathan, Kala, Wilkens, Lynne R, Wolk, Alicja, Zeleniuch-Jacquotte, Anne, and Wentzensen, Nicolas
Published: 2020

11. A Transcriptome-Wide Association Study Identifies Novel Candidate Susceptibility Genes for Pancreatic Cancer

Author: Zhong, Jun, Jermusyk, Ashley, Wu, Lang, Hoskins, Jason W., Collins, Irene, Mocci, Evelina, Zhang, Mingfeng, Song, Lei, Chung, Charles C., Zhang, Tongwu, Xiao, Wenming, Albanes, Demetrius, Andreotti, Gabriella, Arslan, Alan A., Babic, Ana, Bamlet, William R., Beane-Freeman, Laura, Berndt, Sonja, Borgida, Ayelet, Bracci, Paige M., Brais, Lauren, Brennan, Paul, Bueno-de-Mesquita, Bas, Buring, Julie, Canzian, Federico, Childs, Erica J., Cotterchio, Michelle, Du, Mengmeng, Duell, Eric J., Fuchs, Charles, Gallinger, Steven, Gaziano, J. Michael, Giles, Graham G., Giovannucci, Edward, Goggins, Michael, Goodman, Gary E., Goodman, Phyllis J., Haiman, Christopher, Hartge, Patricia, Hasan, Manal, Helzlsouer, Kathy J., Holly, Elizabeth A., Klein, Eric A., Kogevinas, Manolis, Kurtz, Robert J., LeMarchand, Loic, Malats, Nuria, Mannisto, Satu, Milne, Roger, Neale, Rachel E., Ng, Kimmie, Obazee, Ofure, Oberg, Ann L., Orlow, Irene, Patel, Alpa, V, Peters, Ulrike, Porta, Miquel, Rothman, Nathaniel, Scelo, Ghislaine, Sesso, Howard D., Severi, Gianluca, Sieri, Sabina, Silverman, Debra, Sund, Malin, Tjonneland, Anne, Thornquist, Mark D., Tobias, Geoffrey S., Trichopoulou, Antonia, Van den Eeden, Stephen K., Visvanathan, Kala, Wactawski-Wende, Jean, Wentzensen, Nicolas, White, Emily, Yu, Herbert, Yuan, Chen, Zeleniuch-Jacquotte, Anne, Hoover, Robert, Brown, Kevin, Kooperberg, Charles, Risch, Harvey A., Jacobs, Eric J., Li, Donghui, Yu, Kai, Shu, Xiao-Ou, Chanock, Stephen J., Wolpin, Brian M., Stolzenberg-Solomon, Rachael Z., Chatterjee, Nilanjan, Klein, Alison P., Smith, Jill P., Kraft, Peter, Shi, Jianxin, Petersen, Gloria M., Zheng, Wei, Amundadottir, Laufey T., Zhong, Jun, Jermusyk, Ashley, Wu, Lang, Hoskins, Jason W., Collins, Irene, Mocci, Evelina, Zhang, Mingfeng, Song, Lei, Chung, Charles C., Zhang, Tongwu, Xiao, Wenming, Albanes, Demetrius, Andreotti, Gabriella, Arslan, Alan A., Babic, Ana, Bamlet, William R., Beane-Freeman, Laura, Berndt, Sonja, Borgida, Ayelet, Bracci, Paige M., Brais, Lauren, Brennan, Paul, Bueno-de-Mesquita, Bas, Buring, Julie, Canzian, Federico, Childs, Erica J., Cotterchio, Michelle, Du, Mengmeng, Duell, Eric J., Fuchs, Charles, Gallinger, Steven, Gaziano, J. Michael, Giles, Graham G., Giovannucci, Edward, Goggins, Michael, Goodman, Gary E., Goodman, Phyllis J., Haiman, Christopher, Hartge, Patricia, Hasan, Manal, Helzlsouer, Kathy J., Holly, Elizabeth A., Klein, Eric A., Kogevinas, Manolis, Kurtz, Robert J., LeMarchand, Loic, Malats, Nuria, Mannisto, Satu, Milne, Roger, Neale, Rachel E., Ng, Kimmie, Obazee, Ofure, Oberg, Ann L., Orlow, Irene, Patel, Alpa, V, Peters, Ulrike, Porta, Miquel, Rothman, Nathaniel, Scelo, Ghislaine, Sesso, Howard D., Severi, Gianluca, Sieri, Sabina, Silverman, Debra, Sund, Malin, Tjonneland, Anne, Thornquist, Mark D., Tobias, Geoffrey S., Trichopoulou, Antonia, Van den Eeden, Stephen K., Visvanathan, Kala, Wactawski-Wende, Jean, Wentzensen, Nicolas, White, Emily, Yu, Herbert, Yuan, Chen, Zeleniuch-Jacquotte, Anne, Hoover, Robert, Brown, Kevin, Kooperberg, Charles, Risch, Harvey A., Jacobs, Eric J., Li, Donghui, Yu, Kai, Shu, Xiao-Ou, Chanock, Stephen J., Wolpin, Brian M., Stolzenberg-Solomon, Rachael Z., Chatterjee, Nilanjan, Klein, Alison P., Smith, Jill P., Kraft, Peter, Shi, Jianxin, Petersen, Gloria M., Zheng, Wei, and Amundadottir, Laufey T.
Abstract: Background: Although 20 pancreatic cancer susceptibility loci have been identified through genome-wide association studies in individuals of European ancestry, much of its heritability remains unexplained and the genes responsible largely unknown. Methods: To discover novel pancreatic cancer risk loci and possible causal genes, we performed a pancreatic cancer transcriptome-wide association study in Europeans using three approaches: FUSION, MetaXcan, and Summary-MulTiXcan. We integrated genome-wide association studies summary statistics from 9040 pancreatic cancer cases and 12 496 controls, with gene expression prediction models built using transcriptome data from histologically normal pancreatic tissue samples (NCI Laboratory of Translational Genomics [n = 95] and Genotype-Tissue Expression v7 [n = 174] datasets) and data from 48 different tissues (Genotype-Tissue Expression v7, n = 74-421 samples). Results: We identified 25 genes whose genetically predicted expression was statistically significantly associated with pancreatic cancer risk (false discovery rate < .05), including 14 candidate genes at 11 novel loci (1p36.12: CELA3B; 9q31.1: SMC2, SMC2-AS1; 10q23.31: RP11-80H5.9; 12q13.13: SMUG1; 14q32.33: BTBD6; 15q23: HEXA; 15q26.1: RCCD1; 17q12: PNMT, CDK12, PGAP3; 17q22: SUPT4H1; 18q11.22: RP11-888D10.3; and 19p13.11: PGPEPI) and 11 at six known risk loci (5p15.33: TERT, CLPTMIL, ZDHHCIIB; 7p14.1: INHBA; 9q34.2: ABO; 13q12.2: PDX1; 13q22.1: KLF5; and 16q23.1: WDR59, CFDP1, BCAR1, TMEM170A). The association for 12 of these genes (CELA3B, SMC2, and PNMT at novel risk loci and TERT, CLPTMIL, INHBA, ABO, PDX1, KLF5, WDR59, CFDP1, and BCAR1 at known loci) remained statistically significant after Bonferroni correction. Conclusions: By integrating gene expression and genotype data, we identified novel pancreatic cancer risk loci and candidate functional genes that warrant further investigation.
Published: 2020
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12. Associations between reproductive factors and biliary tract cancers in women from the Biliary Tract Cancers Pooling Project.

Author: Jackson, Sarah S, Jackson, Sarah S, Adami, Hans-Olov, Andreotti, Gabriella, Beane-Freeman, Laura E, de González, Amy Berrington, Buring, Julie E, Fraser, Gary E, Freedman, Neal D, Gapstur, Susan M, Gierach, Gretchen, Giles, Graham G, Grodstein, Francine, Hartge, Patricia, Jenab, Mazda, Kirsh, Victoria, Knutsen, Synnove F, Lan, Qing, Larsson, Susanna C, Lee, I-Min, Lee, Mei-Hsuan, Liao, Linda M, Milne, Roger L, Monroe, Kristine R, Neuhouser, Marian L, O'Brien, Katie M, Petrick, Jessica L, Purdue, Mark P, Rohan, Thomas E, Sandin, Sven, Sandler, Dale P, Sawada, Norie, Shadyab, Aladdin H, Simon, Tracey G, Sinha, Rashmi, Stolzenberg-Solomon, Rachael, Tsugane, Shoichiro, Weiderpass, Elisabete, Wolk, Alicja, Yang, Hwai-I, Zheng, Wei, McGlynn, Katherine A, Campbell, Peter T, Koshiol, Jill, Jackson, Sarah S, Jackson, Sarah S, Adami, Hans-Olov, Andreotti, Gabriella, Beane-Freeman, Laura E, de González, Amy Berrington, Buring, Julie E, Fraser, Gary E, Freedman, Neal D, Gapstur, Susan M, Gierach, Gretchen, Giles, Graham G, Grodstein, Francine, Hartge, Patricia, Jenab, Mazda, Kirsh, Victoria, Knutsen, Synnove F, Lan, Qing, Larsson, Susanna C, Lee, I-Min, Lee, Mei-Hsuan, Liao, Linda M, Milne, Roger L, Monroe, Kristine R, Neuhouser, Marian L, O'Brien, Katie M, Petrick, Jessica L, Purdue, Mark P, Rohan, Thomas E, Sandin, Sven, Sandler, Dale P, Sawada, Norie, Shadyab, Aladdin H, Simon, Tracey G, Sinha, Rashmi, Stolzenberg-Solomon, Rachael, Tsugane, Shoichiro, Weiderpass, Elisabete, Wolk, Alicja, Yang, Hwai-I, Zheng, Wei, McGlynn, Katherine A, Campbell, Peter T, and Koshiol, Jill
Abstract: Background & aimsGallbladder cancer (GBC) is known to have a female predominance while other biliary tract cancers (BTCs) have a male predominance. However, the role of female reproductive factors in BTC etiology remains unclear.MethodsWe pooled data from 19 studies of >1.5 million women participating in the Biliary Tract Cancers Pooling Project to examine the associations of parity, age at menarche, reproductive years, and age at menopause with BTC. Associations for age at menarche and reproductive years with BTC were analyzed separately for Asian and non-Asian women. Hazard ratios (HRs) and 95% CIs were estimated using Cox proportional hazards models, stratified by study.ResultsDuring 21,681,798 person-years of follow-up, 875 cases of GBC, 379 of intrahepatic bile duct cancer (IHBDC), 450 of extrahepatic bile duct cancer (EHBDC), and 261 of ampulla of Vater cancer (AVC) occurred. High parity was associated with risk of GBC (HR ≥5 vs. 0 births 1.72; 95% CI 1.25-2.38). Age at menarche (HR per year increase 1.15; 95% CI 1.06-1.24) was associated with GBC risk in Asian women while reproductive years were associated with GBC risk (HR per 5 years 1.13; 95% CI 1.04-1.22) in non-Asian women. Later age at menarche was associated with IHBDC (HR 1.19; 95% CI 1.09-1.31) and EHBDC (HR 1.11; 95% CI 1.01-1.22) in Asian women only.ConclusionWe observed an increased risk of GBC with increasing parity. Among Asian women, older age at menarche was associated with increased risk for GBC, IHBDC, and EHBDC, while increasing reproductive years was associated with GBC in non-Asian women. These results suggest that sex hormones have distinct effects on cancers across the biliary tract that vary by geography.Lay summaryOur findings show that the risk of gallbladder cancer is increased among women who have given birth (especially women with 5 or more children). In women from Asian countries, later age at menarche increases the risk of gallbladder cancer, intrahepatic bile duct cancer
Published: 2020

13. The risk of ovarian cancer increases with an increase in the lifetime number of ovulatory cycles: an analysis from the Ovarian Cancer Cohort Consortium (OC3)

Author: Cardiovasculaire Epi Team 3, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Trabert, Britton, Tworoger, Shelley S, O'Brien, Katie M, Townsend, Mary K, Fortner, Renée T, Iversen, Edwin S, Hartge, Patricia, White, Emily, Amiano, Pilar, Arslan, Alan A, Bernstein, Leslie, Brinton, Louise A, Buring, Julie E, Dossus, Laure, Fraser, Gary E, Gaudet, Mia M, Giles, Graham G, Gram, Inger T, Harris, Holly R, Hoffman Bolton, Judith, Idahl, Annika, Jones, Michael E, Kaaks, Rudolf, Kirsh, Victoria A, Knutsen, Synnove F, Kvaskoff, Marina, Lacey, James V, Lee, I-Min, Milne, Roger L, Onland-Moret, N Charlotte, Overvad, Kim, Patel, Alpa V, Peters, Ulrike, Poynter, Jenny N, Riboli, Elio, Robien, Kim, Rohan, Thomas E, Sandler, Dale P, Schairer, Catherine, Schouten, Leo J, Setiawan, Veronica Wendy, Swerdlow, Anthony J, Travis, Ruth C, Trichopoulou, Antonia, van den Brandt, Piet A, Visvanathan, Kala, Wilkens, Lynne R, Wolk, Alicja, Zeleniuch-Jacquotte, Anne, Wentzensen, Nicolas, Cardiovasculaire Epi Team 3, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Trabert, Britton, Tworoger, Shelley S, O'Brien, Katie M, Townsend, Mary K, Fortner, Renée T, Iversen, Edwin S, Hartge, Patricia, White, Emily, Amiano, Pilar, Arslan, Alan A, Bernstein, Leslie, Brinton, Louise A, Buring, Julie E, Dossus, Laure, Fraser, Gary E, Gaudet, Mia M, Giles, Graham G, Gram, Inger T, Harris, Holly R, Hoffman Bolton, Judith, Idahl, Annika, Jones, Michael E, Kaaks, Rudolf, Kirsh, Victoria A, Knutsen, Synnove F, Kvaskoff, Marina, Lacey, James V, Lee, I-Min, Milne, Roger L, Onland-Moret, N Charlotte, Overvad, Kim, Patel, Alpa V, Peters, Ulrike, Poynter, Jenny N, Riboli, Elio, Robien, Kim, Rohan, Thomas E, Sandler, Dale P, Schairer, Catherine, Schouten, Leo J, Setiawan, Veronica Wendy, Swerdlow, Anthony J, Travis, Ruth C, Trichopoulou, Antonia, van den Brandt, Piet A, Visvanathan, Kala, Wilkens, Lynne R, Wolk, Alicja, Zeleniuch-Jacquotte, Anne, and Wentzensen, Nicolas
Published: 2020

14. The Risk of Ovarian Cancer Increases with an Increase in the Lifetime Number of Ovulatory Cycles: An Analysis from the Ovarian Cancer Cohort Consortium (OC3)

Author: Trabert, Britton, Tworoger, Shelley S., O'Brien, Katie M., Townsend, Mary K., Fortner, Renee T., Iversen, Edwin S., Hartge, Patricia, White, Emily, Amiano, Pilar, Arslan, Alan A., Bernstein, Leslie, Brinton, Louise A., Buring, Julie E., Dossus, Laure, Fraser, Gary E., Gaudet, Mia M., Giles, Graham G., Gram, Inger T., Harris, Holly R., Bolton, Judith Hoffman, Idahl, Annika, Jones, Michael E., Kaaks, Rudolf, Kirsh, Victoria A., Knutsen, Synnove F., Kvaskoff, Marina, Lacey, James, Lee, I-Min, Milne, Roger L., Onland-Moret, N. Charlotte, Overvad, Kim, Patel, Alpa, Peters, Ulrike, Poynter, Jenny N., Riboli, Elio, Robien, Kim, Rohan, Thomas E., Sandler, Dale P., Schairer, Catherine, Schouten, Leo J., Setiawan, Veronica W., Swerdlow, Anthony J., Travis, Ruth C., Trichopoulou, Antonia, van den Brandt, Piet A., Visvanathan, Kala, Wilkens, Lynne R., Wolk, Alicja, Zeleniuch-Jacquotte, Anne, Wentzensen, Nicolas, Ovarian Cancer Cohort Consortium OC3, Trabert, Britton, Tworoger, Shelley S., O'Brien, Katie M., Townsend, Mary K., Fortner, Renee T., Iversen, Edwin S., Hartge, Patricia, White, Emily, Amiano, Pilar, Arslan, Alan A., Bernstein, Leslie, Brinton, Louise A., Buring, Julie E., Dossus, Laure, Fraser, Gary E., Gaudet, Mia M., Giles, Graham G., Gram, Inger T., Harris, Holly R., Bolton, Judith Hoffman, Idahl, Annika, Jones, Michael E., Kaaks, Rudolf, Kirsh, Victoria A., Knutsen, Synnove F., Kvaskoff, Marina, Lacey, James, Lee, I-Min, Milne, Roger L., Onland-Moret, N. Charlotte, Overvad, Kim, Patel, Alpa, Peters, Ulrike, Poynter, Jenny N., Riboli, Elio, Robien, Kim, Rohan, Thomas E., Sandler, Dale P., Schairer, Catherine, Schouten, Leo J., Setiawan, Veronica W., Swerdlow, Anthony J., Travis, Ruth C., Trichopoulou, Antonia, van den Brandt, Piet A., Visvanathan, Kala, Wilkens, Lynne R., Wolk, Alicja, Zeleniuch-Jacquotte, Anne, Wentzensen, Nicolas, and Ovarian Cancer Cohort Consortium OC3
Abstract: Repeated exposure to the acute proinflammatory environment that follows ovulation at the ovarian surface and distal fallopian tube over a woman's reproductive years may increase ovarian cancer risk. To address this, analyses included individual-level data from 558,709 naturally menopausal women across 20 prospective cohorts, among whom 3,246 developed invasive epithelial ovarian cancer (2,045 serous, 319 endometrioid, 184 mucinous, 121 clear cell, 577 other/unknown). Cox models were used to estimate multivariable-adjusted HRs between lifetime ovulatory cycles (LOC) and its components and ovarian cancer risk overall and by histotype. Women in the 90th percentile of LOC (>514 cycles) were almost twice as likely to be diagnosed with ovarian cancer than women in the 10th percentile (Significance: Although ovarian cancer is rare, risk of most ovarian cancers doubles as the number of lifetime ovulatory cycles increases from approximately 300 to 500. Thus, identifying an important area for cancer prevention research.
Published: 2020

15. A Transcriptome-Wide Association Study Identifies Novel Candidate Susceptibility Genes for Pancreatic Cancer

Author: Zhong, Jun, Jermusyk, Ashley, Wu, Lang, Hoskins, Jason W., Collins, Irene, Mocci, Evelina, Zhang, Mingfeng, Song, Lei, Chung, Charles C., Zhang, Tongwu, Xiao, Wenming, Albanes, Demetrius, Andreotti, Gabriella, Arslan, Alan A., Babic, Ana, Bamlet, William R., Beane-Freeman, Laura, Berndt, Sonja, Borgida, Ayelet, Bracci, Paige M., Brais, Lauren, Brennan, Paul, Bueno-de-Mesquita, Bas, Buring, Julie, Canzian, Federico, Childs, Erica J., Cotterchio, Michelle, Du, Mengmeng, Duell, Eric J., Fuchs, Charles, Gallinger, Steven, Gaziano, J. Michael, Giles, Graham G., Giovannucci, Edward, Goggins, Michael, Goodman, Gary E., Goodman, Phyllis J., Haiman, Christopher, Hartge, Patricia, Hasan, Manal, Helzlsouer, Kathy J., Holly, Elizabeth A., Klein, Eric A., Kogevinas, Manolis, Kurtz, Robert J., LeMarchand, Loic, Malats, Nuria, Mannisto, Satu, Milne, Roger, Neale, Rachel E., Ng, Kimmie, Obazee, Ofure, Oberg, Ann L., Orlow, Irene, Patel, Alpa, Peters, Ulrike, Porta, Miquel, Rothman, Nathaniel, Scelo, Ghislaine, Sesso, Howard D., Severi, Gianluca, Sieri, Sabina, Silverman, Debra, Sund, Malin, Tjonneland, Anne, Thornquist, Mark D., Tobias, Geoffrey S., Trichopoulou, Antonia, Van den Eeden, Stephen K., Visvanathan, Kala, Wactawski-Wende, Jean, Wentzensen, Nicolas, White, Emily, Yu, Herbert, Yuan, Chen, Zeleniuch-Jacquotte, Anne, Hoover, Robert, Brown, Kevin, Kooperberg, Charles, Risch, Harvey A., Jacobs, Eric J., Li, Donghui, Yu, Kai, Shu, Xiao-Ou, Chanock, Stephen J., Wolpin, Brian M., Stolzenberg-Solomon, Rachael Z., Chatterjee, Nilanjan, Klein, Alison P., Smith, Jill P., Kraft, Peter, Shi, Jianxin, Petersen, Gloria M., Zheng, Wei, Amundadottir, Laufey T., Zhong, Jun, Jermusyk, Ashley, Wu, Lang, Hoskins, Jason W., Collins, Irene, Mocci, Evelina, Zhang, Mingfeng, Song, Lei, Chung, Charles C., Zhang, Tongwu, Xiao, Wenming, Albanes, Demetrius, Andreotti, Gabriella, Arslan, Alan A., Babic, Ana, Bamlet, William R., Beane-Freeman, Laura, Berndt, Sonja, Borgida, Ayelet, Bracci, Paige M., Brais, Lauren, Brennan, Paul, Bueno-de-Mesquita, Bas, Buring, Julie, Canzian, Federico, Childs, Erica J., Cotterchio, Michelle, Du, Mengmeng, Duell, Eric J., Fuchs, Charles, Gallinger, Steven, Gaziano, J. Michael, Giles, Graham G., Giovannucci, Edward, Goggins, Michael, Goodman, Gary E., Goodman, Phyllis J., Haiman, Christopher, Hartge, Patricia, Hasan, Manal, Helzlsouer, Kathy J., Holly, Elizabeth A., Klein, Eric A., Kogevinas, Manolis, Kurtz, Robert J., LeMarchand, Loic, Malats, Nuria, Mannisto, Satu, Milne, Roger, Neale, Rachel E., Ng, Kimmie, Obazee, Ofure, Oberg, Ann L., Orlow, Irene, Patel, Alpa, Peters, Ulrike, Porta, Miquel, Rothman, Nathaniel, Scelo, Ghislaine, Sesso, Howard D., Severi, Gianluca, Sieri, Sabina, Silverman, Debra, Sund, Malin, Tjonneland, Anne, Thornquist, Mark D., Tobias, Geoffrey S., Trichopoulou, Antonia, Van den Eeden, Stephen K., Visvanathan, Kala, Wactawski-Wende, Jean, Wentzensen, Nicolas, White, Emily, Yu, Herbert, Yuan, Chen, Zeleniuch-Jacquotte, Anne, Hoover, Robert, Brown, Kevin, Kooperberg, Charles, Risch, Harvey A., Jacobs, Eric J., Li, Donghui, Yu, Kai, Shu, Xiao-Ou, Chanock, Stephen J., Wolpin, Brian M., Stolzenberg-Solomon, Rachael Z., Chatterjee, Nilanjan, Klein, Alison P., Smith, Jill P., Kraft, Peter, Shi, Jianxin, Petersen, Gloria M., Zheng, Wei, and Amundadottir, Laufey T.
Abstract: Background: Although 20 pancreatic cancer susceptibility loci have been identified through genome-wide association studies in individuals of European ancestry, much of its heritability remains unexplained and the genes responsible largely unknown. Methods: To discover novel pancreatic cancer risk loci and possible causal genes, we performed a pancreatic cancer transcriptome-wide association study in Europeans using three approaches: FUSION, MetaXcan, and Summary-MulTiXcan. We integrated genome-wide association studies summary statistics from 9040 pancreatic cancer cases and 12 496 controls, with gene expression prediction models built using transcriptome data from histologically normal pancreatic tissue samples (NCI Laboratory of Translational Genomics [n = 95] and Genotype-Tissue Expression v7 [n = 174] datasets) and data from 48 different tissues (Genotype-Tissue Expression v7, n = 74-421 samples). Results: We identified 25 genes whose genetically predicted expression was statistically significantly associated with pancreatic cancer risk (false discovery rate <.05), including 14 candidate genes at 11 novel loci (1p36.12: CELA3B; 9q31.1: SMC2, SMC2-AS1; 10q23.31: RP11-80H5.9; 12q13.13: SMUG1; 14q32.33: BTBD6; 15q23: HEXA; 15q26.1: RCCD1; 17q12: PNMT, CDK12, PGAP3; 17q22: SUPT4H1; 18q11.22: RP11-888D10.3; and 19p13.11: PGPEPI) and 11 at six known risk loci (5p15.33: TERT, CLPTMIL, ZDHHCIIB; 7p14.1: INHBA; 9q34.2: ABO; 13q12.2: PDX1; 13q22.1: KLF5; and 16q23.1: WDR59, CFDP1, BCAR1, TMEM170A). The association for 12 of these genes (CELA3B, SMC2, and PNMT at novel risk loci and TERT, CLPTMIL, INHBA, ABO, PDX1, KLF5, WDR59, CFDP1, and BCAR1 at known loci) remained statistically significant after Bonferroni correction. Conclusions: By integrating gene expression and genotype data, we identified novel pancreatic cancer risk loci and candidate functional genes that warrant further investigation.
Published: 2020

16. Genome-Wide Gene-Diabetes and Gene-Obesity Interaction Scan in 8,255 Cases and 11,900 Controls from PanScan and PanC4 Consortia

Author: Tang, Hongwei, Jiang, Lai, Stolzenberg-Solomon, Rachael Z., Arslan, Alan A., Freeman, Laura E. Beane, Bracci, Paige M., Brennan, Paul, Canzian, Federico, Du, Mengmeng, Gallinger, Steven, Giles, Graham G., Goodman, Phyllis J., Kooperberg, Charles, Le Marchand, Loic, Neale, Rachel E., Shu, Xiao-Ou, Visvanathan, Kala, White, Emily, Zheng, Wei, Albanes, Demetrius, Andreotti, Gabriella, Babic, Ana, Bamlet, William R., Berndt, Sonja, Blackford, Amanda, Bueno-de-Mesquita, Bas, Buring, Julie E., Campa, Daniele, Chanock, Stephen J., Childs, Erica, Duell, Eric J., Fuchs, Charles, Gaziano, J. Michael, Goggins, Michael, Hartge, Patricia, Hassam, Manal H., Holly, Elizabeth A., Hoover, Robert N., Hung, Rayjean J., Kurtz, Robert C., Lee, I-Min, Malats, Nuria, Milne, Roger L., Ng, Kimmie, Oberg, Ann L., Orlow, Irene, Peters, Ulrike, Porta, Miquel, Rabe, Kari G., Rothman, Nathaniel, Scelo, Ghislaine, Sesso, Howard D., Silverman, Debra T., Thompson, Ian M., Tjønneland, Anne, Trichopoulou, Antonia, Wactawski-Wende, Jean, Wentzensen, Nicolas, Wilkens, Lynne R., Yu, Herbert, Zeleniuch-Jacquotte, Anne, Amundadottir, Laufey T., Jacobs, Eric J., Petersen, Gloria M., Wolpin, Brian M., Risch, Harvey A., Chatterjee, Nilanjan, Klein, Alison P., Li, Donghui, Kraft, Peter, Wei, Peng, Tang, Hongwei, Jiang, Lai, Stolzenberg-Solomon, Rachael Z., Arslan, Alan A., Freeman, Laura E. Beane, Bracci, Paige M., Brennan, Paul, Canzian, Federico, Du, Mengmeng, Gallinger, Steven, Giles, Graham G., Goodman, Phyllis J., Kooperberg, Charles, Le Marchand, Loic, Neale, Rachel E., Shu, Xiao-Ou, Visvanathan, Kala, White, Emily, Zheng, Wei, Albanes, Demetrius, Andreotti, Gabriella, Babic, Ana, Bamlet, William R., Berndt, Sonja, Blackford, Amanda, Bueno-de-Mesquita, Bas, Buring, Julie E., Campa, Daniele, Chanock, Stephen J., Childs, Erica, Duell, Eric J., Fuchs, Charles, Gaziano, J. Michael, Goggins, Michael, Hartge, Patricia, Hassam, Manal H., Holly, Elizabeth A., Hoover, Robert N., Hung, Rayjean J., Kurtz, Robert C., Lee, I-Min, Malats, Nuria, Milne, Roger L., Ng, Kimmie, Oberg, Ann L., Orlow, Irene, Peters, Ulrike, Porta, Miquel, Rabe, Kari G., Rothman, Nathaniel, Scelo, Ghislaine, Sesso, Howard D., Silverman, Debra T., Thompson, Ian M., Tjønneland, Anne, Trichopoulou, Antonia, Wactawski-Wende, Jean, Wentzensen, Nicolas, Wilkens, Lynne R., Yu, Herbert, Zeleniuch-Jacquotte, Anne, Amundadottir, Laufey T., Jacobs, Eric J., Petersen, Gloria M., Wolpin, Brian M., Risch, Harvey A., Chatterjee, Nilanjan, Klein, Alison P., Li, Donghui, Kraft, Peter, and Wei, Peng
Abstract: Background: Obesity and diabetes are major modifiable risk factors for pancreatic cancer. Interactions between genetic variants and diabetes/obesity have not previously been comprehensively investigated in pancreatic cancer at the genome-wide level.Methods: We conducted a gene-environment interaction (GxE) analysis including 8,255 cases and 11,900 controls from four pancreatic cancer genome-wide association study (GWAS) datasets (Pancreatic Cancer Cohort Consortium I-III and Pancreatic Cancer Case Control Consortium). Obesity (body mass index >= 30 kg/m(2)) and diabetes (duration >= 3 years) were the environmental variables of interest. Approximately 870,000 SNPs (minor allele frequency >= 0.005, genotyped in at least one dataset) were analyzed. Case-control ( CC), case-only (CO), and joint-effect test methods were used for SNP-level GxE analysis. As a complementary approach, gene-based GxE analysis was also performed. Age, sex, study site, and principal components accounting for population substructure were included as covari- ates. Meta-analysis was applied to combine individual GWAS summary statistics.Results: No genome-wide significant interactions (departures from a log-additive odds model) with diabetes or obesity were detected at the SNP level by the CC or CO approaches. The jointeffect test detected numerous genome-wide significant GxE signals in the GWAS main effects top hit regions, but the significance diminished after adjusting for theGWAStop hits. In the gene-based analysis, a significant interaction of diabetes with variants in the FAM63A (family with sequence similarity 63 member A) gene (significance threshold P <1.25 x 10(-6)) was observed in the meta-analysis (P-GxE = 1.2 x 10(-6), P-Joint = 4.2 x 10(-7)).Conclusions: This analysis did not find significant GxE interactions at the SNP level but found one significant interaction with diabetes at the gene level. A larger sample size might unveil additional genetic f
Published: 2020

17. Anthropometric Risk Factors for Cancers of the Biliary Tract in the Biliary Tract Cancers Pooling Project

Author: Jackson, Sarah S., Van Dyke, Alison L., Zhu, Bin, Pfeiffer, Ruth M., Petrick, Jessica L., Adami, Hans-Olov, Albanes, Demetrius, Andreotti, Gabriella, Freeman, Laura E. Beane, de Gonzalez, Amy Berrington, Buring, Julie E., Chan, Andrew T., Chen, Yu, Fraser, Gary E., Freedman, Neal D., Gao, Yu-Tang, Gapstur, Susan M., Gaziano, J. Michael, Giles, Graham G., Grant, Eric J., Grodstein, Francine, Hartge, Patricia, Jenab, Mazda, Kitahara, Cari M., Knutsen, Synnove F., Koh, Woon-Puay, Larsson, Susanna C., Lee, I-Min, Liao, Linda M., Luo, Juhua, McGee, Emma E., Milne, Roger L., Monroe, Kristine R., Neuhouser, Marian L., O'Brien, Katie M., Peters, Ulrike, Poynter, Jenny N., Purdue, Mark P., Robien, Kim, Sandler, Dale P., Sawada, Norie, Schairer, Catherine, Sesso, Howard D., Simon, Tracey G., Sinha, Rashmi, Stolzenberg-Solomon, Rachael Z., Tsugane, Shoichiro, Wang, Renwei, Weiderpass, Elisabete, Weinstein, Stephanie J., White, Emily, Wolk, Alicja, Yuan, Jian-Min, Zeleniuch-Jacquotte, Anne, Zhang, Xuehong, McGlynn, Katherine A., Campbell, Peter T., Koshiol, Jill, Jackson, Sarah S., Van Dyke, Alison L., Zhu, Bin, Pfeiffer, Ruth M., Petrick, Jessica L., Adami, Hans-Olov, Albanes, Demetrius, Andreotti, Gabriella, Freeman, Laura E. Beane, de Gonzalez, Amy Berrington, Buring, Julie E., Chan, Andrew T., Chen, Yu, Fraser, Gary E., Freedman, Neal D., Gao, Yu-Tang, Gapstur, Susan M., Gaziano, J. Michael, Giles, Graham G., Grant, Eric J., Grodstein, Francine, Hartge, Patricia, Jenab, Mazda, Kitahara, Cari M., Knutsen, Synnove F., Koh, Woon-Puay, Larsson, Susanna C., Lee, I-Min, Liao, Linda M., Luo, Juhua, McGee, Emma E., Milne, Roger L., Monroe, Kristine R., Neuhouser, Marian L., O'Brien, Katie M., Peters, Ulrike, Poynter, Jenny N., Purdue, Mark P., Robien, Kim, Sandler, Dale P., Sawada, Norie, Schairer, Catherine, Sesso, Howard D., Simon, Tracey G., Sinha, Rashmi, Stolzenberg-Solomon, Rachael Z., Tsugane, Shoichiro, Wang, Renwei, Weiderpass, Elisabete, Weinstein, Stephanie J., White, Emily, Wolk, Alicja, Yuan, Jian-Min, Zeleniuch-Jacquotte, Anne, Zhang, Xuehong, McGlynn, Katherine A., Campbell, Peter T., and Koshiol, Jill
Abstract: Biliary tract cancers are rare but highly fatal with poorly understood etiology. Identifying potentially modifiable risk factors for these cancers is essential for prevention. Here we estimated the relationship between adiposity and cancer across the biliary tract, including cancers of the gallbladder (GBC), intrahepatic bile ducts (IHBDC), extrahepatic bile ducts (EHBDC), and the ampulla of Vater (AVC). We pooled data from 27 prospective cohorts with over 2.7 million adults. Adiposity was measured using baseline body mass index (BMI), waist circumference, hip circumference, waist-to-hip, and waist-to-height ratios. HRs and 95% confidence intervals (95% CI) were estimated using Cox proportional hazards models adjusted for sex, education, race, smoking, and alcohol consumption with age as the time metric and the baseline hazard stratified by study. During 37,883,648 person-years of follow-up, 1,343 GBC cases, 1,194 EHBDC cases, 784 IHBDC cases, and 623 AVC cases occurred. For each 5 kg/m(2) increase in BMI, there were risk increases for GBC (HR = 1.27; 95% CI, 1.19-1.36), IHBDC (HR = 1.32; 95% CI, 1.21-1.45), and EHBDC (HR = 1.13; 95% CI, 1.03-1.23), but not AVC (HR = 0.99; 95% CI, 0.88-1.11). Increasing waist circumference, hip circumference, waist-to-hip ratio, and waist-to-height ratio were associated with GBC and IHBDC but not EHBDC or AVC. These results indicate that adult adiposity is associated with an increased risk of biliary tract cancer, particularly GBC and IHBDC. Moreover, they provide evidence for recommending weight maintenance programs to reduce the risk of developing these cancers. Significance: These findings identify a correlation between adiposity and biliary tract cancers, indicating that weight management programs may help minimize the risk of these diseases.
Published: 2019
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18. Ovarian cancer risk factors by tumor aggressiveness : An analysis from the Ovarian Cancer Cohort Consortium

Author: Fortner, Renée T., Poole, Elizabeth M., Wentzensen, Nicolas A., Trabert, Britton, White, Emily, Arslan, Alan A., Patel, Alpa V., Setiawan, V. Wendy, Visvanathan, Kala, Weiderpass, Elisabete, Adami, Hans-Olov, Black, Amanda, Bernstein, Leslie, Brinton, Louise A., Buring, Julie, Clendenen, Tess V., Fournier, Agnès, Fraser, Gary, Gapstur, Susan M., Gaudet, Mia M., Giles, Graham G., Gram, Inger T., Hartge, Patricia, Hoffman-Bolton, Judith, Idahl, Annika, Kaaks, Rudolf, Kirsh, Victoria A., Knutsen, Synnove, Koh, Woon-Puay, Lacey, James V., Lee, I-Min, Lundin, Eva, Merritt, Melissa A., Milne, Roger L., Onland-Moret, N. Charlotte, Peters, Ulrike, Poynter, Jenny N., Rinaldi, Sabina, Robien, Kim, Rohan, Thomas, Sánchez, Maria-José, Schairer, Catherine, Schouten, Leo J., Tjonneland, Anne, Townsend, Mary K., Travis, Ruth C., Trichopoulou, Antonia, van den Brandt, Piet A., Vineis, Paolo, Wilkens, Lynne, Wolk, Alicja, Yang, Hannah P., Zeleniuch-Jacquotte, Anne, Tworoger, Shelley S., Fortner, Renée T., Poole, Elizabeth M., Wentzensen, Nicolas A., Trabert, Britton, White, Emily, Arslan, Alan A., Patel, Alpa V., Setiawan, V. Wendy, Visvanathan, Kala, Weiderpass, Elisabete, Adami, Hans-Olov, Black, Amanda, Bernstein, Leslie, Brinton, Louise A., Buring, Julie, Clendenen, Tess V., Fournier, Agnès, Fraser, Gary, Gapstur, Susan M., Gaudet, Mia M., Giles, Graham G., Gram, Inger T., Hartge, Patricia, Hoffman-Bolton, Judith, Idahl, Annika, Kaaks, Rudolf, Kirsh, Victoria A., Knutsen, Synnove, Koh, Woon-Puay, Lacey, James V., Lee, I-Min, Lundin, Eva, Merritt, Melissa A., Milne, Roger L., Onland-Moret, N. Charlotte, Peters, Ulrike, Poynter, Jenny N., Rinaldi, Sabina, Robien, Kim, Rohan, Thomas, Sánchez, Maria-José, Schairer, Catherine, Schouten, Leo J., Tjonneland, Anne, Townsend, Mary K., Travis, Ruth C., Trichopoulou, Antonia, van den Brandt, Piet A., Vineis, Paolo, Wilkens, Lynne, Wolk, Alicja, Yang, Hannah P., Zeleniuch-Jacquotte, Anne, and Tworoger, Shelley S.
Abstract: Ovarian cancer risk factors differ by histotype; however, within subtype, there is substantial variability in outcomes. We hypothesized that risk factor profiles may influence tumor aggressiveness, defined by time between diagnosis and death, independent of histology. Among 1.3 million women from 21 prospective cohorts, 4,584 invasive epithelial ovarian cancers were identified and classified as highly aggressive (death in <1 year, n = 864), very aggressive (death in 1 to < 3 years, n = 1,390), moderately aggressive (death in 3 to < 5 years, n = 639), and less aggressive (lived 5+ years, n = 1,691). Using competing risks Cox proportional hazards regression, we assessed heterogeneity of associations by tumor aggressiveness for all cases and among serous and endometrioid/clear cell tumors. Associations between parity (phet = 0.01), family history of ovarian cancer (phet = 0.02), body mass index (BMI; phet ≤ 0.04) and smoking (phet < 0.01) and ovarian cancer risk differed by aggressiveness. A first/single pregnancy, relative to nulliparity, was inversely associated with highly aggressive disease (HR: 0.72; 95% CI [0.58-0.88]), no association was observed for subsequent pregnancies (per pregnancy, 0.97 [0.92-1.02]). In contrast, first and subsequent pregnancies were similarly associated with less aggressive disease (0.87 for both). Family history of ovarian cancer was only associated with risk of less aggressive disease (1.94 [1.47-2.55]). High BMI (≥35 vs. 20 to < 25 kg/m2 , 1.93 [1.46-2.56] and current smoking (vs. never, 1.30 [1.07-1.57]) were associated with increased risk of highly aggressive disease. Results were similar within histotypes. Ovarian cancer risk factors may be directly associated with subtypes defined by tumor aggressiveness, rather than through differential effects on histology. Studies to assess biological pathways are warranted.
Published: 2019
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19. Smoking, Alcohol, and Biliary Tract Cancer Risk : A Pooling Project of 26 Prospective Studies

Author: McGee, Emma E., Jackson, Sarah S., Petrick, Jessica L., Van Dyke, Alison L., Adami, Hans-Olov, Albanes, Demetrius, Andreotti, Gabriella, Beane-Freeman, Laura E., de Gonzalez, Amy Berrington, Buring, Julie E., Chan, Andrew T., Chen, Yu, Fraser, Gary E., Freedman, Neal D., Gao, Yu-Tang, Gapstur, Susan M., Gaziano, J. Michael, Giles, Graham G., Grant, Eric J., Grodstein, Francine, Hartge, Patricia, Jenab, Mazda, Kitahara, Cari M., Knutsen, Synnove F., Koh, Woon-Puay, Larsson, Susanna C., Lee, I-Min, Liao, Linda M., Luo, Juhua, Milne, Roger L., Monroe, Kristine R., Neuhouser, Marian L., O'Brien, Katie M., Peters, Ulrike, Poynter, Jenny N., Purdue, Mark P., Robien, Kim, Sandler, Dale P., Sawada, Norie, Schairer, Catherine, Sesso, Howard D., Simon, Tracey G., Sinha, Rashmi, Stolzenberg-Solomon, Rachael, Tsugane, Shoichiro, Wang, Renwei, Weiderpass, Elisabete, Weinstein, Stephanie J., White, Emily, Wolk, Alicja, Yuan, Jian-Min, Zeleniuch-Jacquotte, Anne, Zhang, Xuehong, Zhu, Bin, McGlynn, Katherine A., Campbell, Peter T., Koshiol, Jill, McGee, Emma E., Jackson, Sarah S., Petrick, Jessica L., Van Dyke, Alison L., Adami, Hans-Olov, Albanes, Demetrius, Andreotti, Gabriella, Beane-Freeman, Laura E., de Gonzalez, Amy Berrington, Buring, Julie E., Chan, Andrew T., Chen, Yu, Fraser, Gary E., Freedman, Neal D., Gao, Yu-Tang, Gapstur, Susan M., Gaziano, J. Michael, Giles, Graham G., Grant, Eric J., Grodstein, Francine, Hartge, Patricia, Jenab, Mazda, Kitahara, Cari M., Knutsen, Synnove F., Koh, Woon-Puay, Larsson, Susanna C., Lee, I-Min, Liao, Linda M., Luo, Juhua, Milne, Roger L., Monroe, Kristine R., Neuhouser, Marian L., O'Brien, Katie M., Peters, Ulrike, Poynter, Jenny N., Purdue, Mark P., Robien, Kim, Sandler, Dale P., Sawada, Norie, Schairer, Catherine, Sesso, Howard D., Simon, Tracey G., Sinha, Rashmi, Stolzenberg-Solomon, Rachael, Tsugane, Shoichiro, Wang, Renwei, Weiderpass, Elisabete, Weinstein, Stephanie J., White, Emily, Wolk, Alicja, Yuan, Jian-Min, Zeleniuch-Jacquotte, Anne, Zhang, Xuehong, Zhu, Bin, McGlynn, Katherine A., Campbell, Peter T., and Koshiol, Jill
Abstract: Background: Tobacco and alcohol are well-established risk factors for numerous cancers, yet their relationship to biliary tract cancers remains unclear. Methods: We pooled data from 26 prospective studies to evaluate associations of cigarette smoking and alcohol consumption with biliary tract cancer risk. Study-specific hazard ratios (HRs) and 95% confidence intervals (CIs) for associations with smoking and alcohol consumption were calculated. Random-effects meta-analysis produced summary estimates. All statistical tests were two-sided. Results: Over a period of 38 369 156 person-years of follow-up, 1391 gallbladder, 758 intrahepatic bile duct, 1208 extrahepatic bile duct, and 623 ampulla of Vater cancer cases were identified. Ever, former, and current smoking were associated with increased extrahepatic bile duct and ampulla of Vater cancers risk (eg, current vs never smokers HR = 1.69, 95% CI = 1.34 to 2.13 and 2.22, 95% CI = 1.69 to 2.92, respectively), with dose-response effects for smoking pack-years, duration, and intensity (all P-trend<.01). Current smoking and smoking intensity were also associated with intrahepatic bile duct cancer (eg, >40 cigarettes per day vs never smokers HR = 2.15, 95 % CI = 1.15 to 4.00; P-trend = .001). No convincing association was observed between smoking and gallbladder cancer. Alcohol consumption was only associated with intrahepatic bile duct cancer, with increased risk for individuals consuming five or more vs zero drinks per day (HR = 2.35, 95%CI = 1.46 to 3.78; P-trend = .04). There was evidence of statistical heterogeneity among several cancer sites, particularly between gallbladder cancer and the other biliary tract cancers. Conclusions: Smoking appears to increase the risk of developing all biliary tract cancers except gallbladder cancer. Alcohol may increase the risk of intrahepatic bile duct cancer. Findings highlight etiologic heterogeneity across the biliary tract.
Published: 2019
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20. Agnostic Pathway/Gene Set Analysis of Genome-Wide Association Data Identifies Associations for Pancreatic Cancer

Author: Walsh, Naomi, Zhang, Han, Hyland, Paula L., Yang, Qi, Mocci, Evelina, Zhang, Mingfeng, Childs, Erica J., Collins, Irene, Wang, Zhaoming, Arslan, Alan A., Beane-Freeman, Laura, Bracci, Paige M., Brennan, Paul, Canzian, Federico, Duell, Eric J., Gallinger, Steven, Giles, Graham G., Goggins, Michael, Goodman, Gary E., Goodman, Phyllis J., Hung, Rayjean J., Kooperberg, Charles, Kurtz, Robert C., Malats, Núria, LeMarchand, Loic, Neale, Rachel E., Olson, Sara H., Scelo, Ghislaine, Shu, Xiao O., Van Den Eeden, Stephen K., Visvanathan, Kala, White, Emily, Zheng, Wei, Albanes, Demetrius, Andreotti, Gabriella, Babic, Ana, Bamlet, William R., Berndt, Sonja I., Borgida, Ayelet, Boutron-Ruault, Marie-Christine, Brais, Lauren, Bueno-de-Mesquita, Bas, Buring, Julie, Chaffee, Kari G., Chanock, Stephen, Cleary, Sean, Cotterchio, Michelle, Foretova, Lenka, Fuchs, Charles, M. Gaziano, J. Michael, Giovannucci, Edward, Hackert, Thilo, Haiman, Christopher, Hartge, Patricia, Hasan, Manal, Helzlsouer, Kathy J., Herman, Joseph, Holcatova, Ivana, Holly, Elizabeth A., Hoover, Robert, Janout, Vladimir, Klein, Eric A., Laheru, Daniel, Lee, I-Min, Lu, Lingeng, Mannisto, Satu, Milne, Roger L., Oberg, Ann L., Orlow, Irene, Patel, Alpa V., Peters, Ulrike, Porta, Miquel, Real, Francisco X., Rothman, Nathaniel, Sesso, Howard D., Severi, Gianluca, Silverman, Debra, Strobel, Oliver, Sund, Malin, Thornquist, Mark D., Tobias, Geoffrey S., Wactawski-Wende, Jean, Wareham, Nick, Weiderpass, Elisabete, Wentzensen, Nicolas, Wheeler, William, Yu, Herbert, Zeleniuch-Jacquotte, Anne, Kraft, Peter, Li, Donghui, Jacobs, Eric J., Petersen, Gloria M., Wolpin, Brian M., Risch, Harvey A., Amundadottir, Laufey T., Yu, Kai, Klein, Alison P., Stolzenberg-Solomon, Rachael Z., Walsh, Naomi, Zhang, Han, Hyland, Paula L., Yang, Qi, Mocci, Evelina, Zhang, Mingfeng, Childs, Erica J., Collins, Irene, Wang, Zhaoming, Arslan, Alan A., Beane-Freeman, Laura, Bracci, Paige M., Brennan, Paul, Canzian, Federico, Duell, Eric J., Gallinger, Steven, Giles, Graham G., Goggins, Michael, Goodman, Gary E., Goodman, Phyllis J., Hung, Rayjean J., Kooperberg, Charles, Kurtz, Robert C., Malats, Núria, LeMarchand, Loic, Neale, Rachel E., Olson, Sara H., Scelo, Ghislaine, Shu, Xiao O., Van Den Eeden, Stephen K., Visvanathan, Kala, White, Emily, Zheng, Wei, Albanes, Demetrius, Andreotti, Gabriella, Babic, Ana, Bamlet, William R., Berndt, Sonja I., Borgida, Ayelet, Boutron-Ruault, Marie-Christine, Brais, Lauren, Bueno-de-Mesquita, Bas, Buring, Julie, Chaffee, Kari G., Chanock, Stephen, Cleary, Sean, Cotterchio, Michelle, Foretova, Lenka, Fuchs, Charles, M. Gaziano, J. Michael, Giovannucci, Edward, Hackert, Thilo, Haiman, Christopher, Hartge, Patricia, Hasan, Manal, Helzlsouer, Kathy J., Herman, Joseph, Holcatova, Ivana, Holly, Elizabeth A., Hoover, Robert, Janout, Vladimir, Klein, Eric A., Laheru, Daniel, Lee, I-Min, Lu, Lingeng, Mannisto, Satu, Milne, Roger L., Oberg, Ann L., Orlow, Irene, Patel, Alpa V., Peters, Ulrike, Porta, Miquel, Real, Francisco X., Rothman, Nathaniel, Sesso, Howard D., Severi, Gianluca, Silverman, Debra, Strobel, Oliver, Sund, Malin, Thornquist, Mark D., Tobias, Geoffrey S., Wactawski-Wende, Jean, Wareham, Nick, Weiderpass, Elisabete, Wentzensen, Nicolas, Wheeler, William, Yu, Herbert, Zeleniuch-Jacquotte, Anne, Kraft, Peter, Li, Donghui, Jacobs, Eric J., Petersen, Gloria M., Wolpin, Brian M., Risch, Harvey A., Amundadottir, Laufey T., Yu, Kai, Klein, Alison P., and Stolzenberg-Solomon, Rachael Z.
Abstract: Background: Genome-wide association studies (GWAS) identify associations of individual single-nucleotide polymorphisms (SNPs) with cancer risk but usually only explain a fraction of the inherited variability. Pathway analysis of genetic variants is a powerful tool to identify networks of susceptibility genes. Methods: We conducted a large agnostic pathway-based meta-analysis of GWAS data using the summary-based adaptive rank truncated product method to identify gene sets and pathways associated with pancreatic ductal adenocarcinoma (PDAC) in 9040 cases and 12 496 controls. We performed expression quantitative trait loci (eQTL) analysis and functional annotation of the top SNPs in genes contributing to the top associated pathways and gene sets. All statistical tests were two-sided. Results: We identified 14 pathways and gene sets associated with PDAC at a false discovery rate of less than 0.05. After Bonferroni correction (P ≤ 1.3 × 10-5), the strongest associations were detected in five pathways and gene sets, including maturity-onset diabetes of the young, regulation of beta-cell development, role of epidermal growth factor (EGF) receptor transactivation by G protein-coupled receptors in cardiac hypertrophy pathways, and the Nikolsky breast cancer chr17q11-q21 amplicon and Pujana ATM Pearson correlation coefficient (PCC) network gene sets. We identified and validated rs876493 and three correlating SNPs (PGAP3) and rs3124737 (CASP7) from the Pujana ATM PCC gene set as eQTLs in two normal derived pancreas tissue datasets. Conclusion: Our agnostic pathway and gene set analysis integrated with functional annotation and eQTL analysis provides insight into genes and pathways that may be biologically relevant for risk of PDAC, including those not previously identified.
Published: 2019
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21. High Levels of C-Reactive Protein Are Associated with an Increased Risk of Ovarian Cancer : Results from the Ovarian Cancer Cohort Consortium

Author: Peres, Lauren C., Mallen, Adrianne R., Townsend, Mary K., Poole, Elizabeth M., Trabert, Britton, Allen, Naomi E., Arslan, Alan A., Dossus, Laure, Fortner, Renee T., Gram, Inger T., Hartge, Patricia, Idahl, Annika, Kaaks, Rudolf, Kvaskoff, Marina, Magliocco, Anthony M., Merritt, Melissa A., Quiros, J. Ramon, Tjonneland, Anne, Trichopoulou, Antonia, Tumino, Rosario, van Gils, Carla H., Visvanathan, Kala, Wentzensen, Nicolas, Zeleniuch-Jacquotte, Anne, Tworoger, Shelley S., Peres, Lauren C., Mallen, Adrianne R., Townsend, Mary K., Poole, Elizabeth M., Trabert, Britton, Allen, Naomi E., Arslan, Alan A., Dossus, Laure, Fortner, Renee T., Gram, Inger T., Hartge, Patricia, Idahl, Annika, Kaaks, Rudolf, Kvaskoff, Marina, Magliocco, Anthony M., Merritt, Melissa A., Quiros, J. Ramon, Tjonneland, Anne, Trichopoulou, Antonia, Tumino, Rosario, van Gils, Carla H., Visvanathan, Kala, Wentzensen, Nicolas, Zeleniuch-Jacquotte, Anne, and Tworoger, Shelley S.
Abstract: Growing epidemiologic evidence supports chronic inflammation as a mechanism of ovarian carcinogenesis. An association between a circulating marker of inflammation, C-reactive protein (CRP), and ovarian cancer risk has been consistently observed, yet, potential heterogeneity of this association by tumor and patient characteristics has not been adequately explored. In this study, we pooled data from case-control studies nested within six cohorts in the Ovarian Cancer Cohort Consortium (OC3) to examine the association between CRP and epithelial ovarian cancer risk overall, by histologic subtype and by participant characteristics. CRP concentrations were measured from prediagnosis serum or plasma in 1,091 cases and 1,951 controls. Multivariable conditional logistic regression was used to estimate ORs and 95% confidence intervals (CI). When CRP was evaluated using tertiles, no associations with ovarian cancer risk were observed. A 67% increased ovarian cancer risk was found for women with CRP concentrations >10 mg/L compared with <1 mg/L (OR = 1.67; 95% CI = 1.12-2.48). A CRP concentration >10 mg/L was positively associated with risk of mucinous (OR = 9.67; 95% CI = 1.10-84.80) and endometrioid carcinoma (OR = 3.41; 95% CI = 1.07-10.92), and suggestively positive, although not statistically significant, for serous (OR = 1.43; 95% CI = 0.82-2.49) and clear cell carcinoma (OR = 2.05; 95% CI = 0.36-11.57; P-heterogeneity = 0.20). Heterogeneity was observed with oral contraceptive use (P-interaction = 0.03), where the increased risk was present only among ever users (OR = 3.24; 95% CI = 1.62-6.47). This study adds to the existing evidence that CRP plays a role in ovarian carcinogenesis and suggests that inflammation may be particularly implicated in the etiology of endometrioid and mucinous carcinoma. Significance: C-reactive protein is involved in ovarian carcinogenesis, and chronic inflammation may be particularly implicated in the etiology of mucinous and endomet
Published: 2019
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22. Antibodies Against Chlamydia trachomatis and Ovarian Cancer Risk in Two Independent Populations

Author: Trabert, Britton, Waterboer, Tim, Idahl, Annika, Brenner, Nicole, Brinton, Louise A., Butt, Julia, Coburn, Sally B., Hartge, Patricia, Hufnagel, Katrin, Inturrisi, Federica, Lissowska, Jolanta, Mentzer, Alexander, Peplonska, Beata, Sherman, Mark E., Wills, Gillian S., Woodhall, Sarah C., Pawlita, Michael, Wentzensen, Nicolas, Trabert, Britton, Waterboer, Tim, Idahl, Annika, Brenner, Nicole, Brinton, Louise A., Butt, Julia, Coburn, Sally B., Hartge, Patricia, Hufnagel, Katrin, Inturrisi, Federica, Lissowska, Jolanta, Mentzer, Alexander, Peplonska, Beata, Sherman, Mark E., Wills, Gillian S., Woodhall, Sarah C., Pawlita, Michael, and Wentzensen, Nicolas
Abstract: Background: Pelvic inflammatory disease (PID) has been associated with ovarian cancer risk. To clarify the role of Chlamydia trachomatis and other infectious agents in the development of ovarian cancer, we evaluated the association of serologic markers with incident ovarian cancer using a staged approach in two independent populations. Methods: Studies included: 1) a case-control study in Poland (244 ovarian cancers/556 control subjects) and 2) a prospective nested case-control study in the PLCO Cancer Screening Trial (160 ovarian cancers/159 control subjects). Associations of serologic marker levels with ovarian cancer risk at diagnostic as well as higher thresholds, identified in Poland and independently evaluated in PLCO, were estimated using multivariable adjusted logistic regression. Results: In the Polish study, antibodies (based on laboratory cut-point) against the chlamydia plasmid-encoded Pgp3 protein (serological gold standard) were associated with increased ovarian cancer risk (adjusted odds ratio [OR] = 1.63, 95% confidence interval [CI] = 1.20 to 2.22); when a positive result was redefined at higher levels, ovarian cancer risk was increased (cut-point 2: OR = 2.00, 95% CI = 1.38 to 2.89; cut-point 3 [max OR]: OR = 2.19, 95% CI = 1.29 to 3.73). In the prospective PLCO study, Pgp3 antibodies were associated with elevated risk at the laboratory cut-point (OR = 1.43, 95% CI = 0.78 to 2.63) and more stringent cut-points (cut-point 2: OR = 2.25, 95% CI = 1.07 to 4.71); cut-point 3: OR = 2.53, 95% CI = 0.63 to 10.08). In both studies, antibodies against other infectious agents measured were not associated with risk. Conclusions: In two independent populations, antibodies against prior/current C. trachomatis (Pgp3) were associated with a doubling in ovarian cancer risk, whereas markers of other infectious agents were unrelated. These findings lend support for an association between PID and ovarian cancer.
Published: 2019
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23. Ovarian cancer risk factors by tumor aggressiveness : an analysis from the Ovarian Cancer Cohort Consortium

Author: Fortner, Renee T., Poole, Elizabeth M., Wentzensen, Nicolas A., Trabert, Britton, White, Emily, Arslan, Alan A., Patel, Alpa, V, Setiawan, V. Wendy, Visvanathan, Kala, Weiderpass, Elisabete, Adami, Hans-Olov, Black, Amanda, Bernstein, Leslie, Brinton, Louise A., Buring, Julie, Clendenen, Tess, V, Fournier, Agnes, Fraser, Gary, Gapstur, Susan M., Gaudet, Mia M., Giles, Graham G., Gram, Inger T., Hartge, Patricia, Hoffman-Bolton, Judith, Idahl, Annika, Kaaks, Rudolf, Kirsh, Victoria A., Knutsen, Synnove, Koh, Woon-Puay, Lacey, James V., Jr., Lee, I-Min, Lundin, Eva, Merritt, Melissa A., Milne, Roger L., Onland-Moret, N. Charlotte, Peters, Ulrike, Poynter, Jenny N., Rinaldi, Sabina, Robien, Kim, Rohan, Thomas, Sanchez, Maria-Jose, Schairer, Catherine, Schouten, Leo J., Tjonneland, Anne, Townsend, Mary K., Travis, Ruth C., Trichopoulou, Antonia, van den Brandt, Piet A., Vineis, Paolo, Wilkens, Lynne, Wolk, Alicja, Yang, Hannah P., Zeleniuch-Jacquotte, Anne, Tworoger, Shelley S., Fortner, Renee T., Poole, Elizabeth M., Wentzensen, Nicolas A., Trabert, Britton, White, Emily, Arslan, Alan A., Patel, Alpa, V, Setiawan, V. Wendy, Visvanathan, Kala, Weiderpass, Elisabete, Adami, Hans-Olov, Black, Amanda, Bernstein, Leslie, Brinton, Louise A., Buring, Julie, Clendenen, Tess, V, Fournier, Agnes, Fraser, Gary, Gapstur, Susan M., Gaudet, Mia M., Giles, Graham G., Gram, Inger T., Hartge, Patricia, Hoffman-Bolton, Judith, Idahl, Annika, Kaaks, Rudolf, Kirsh, Victoria A., Knutsen, Synnove, Koh, Woon-Puay, Lacey, James V., Jr., Lee, I-Min, Lundin, Eva, Merritt, Melissa A., Milne, Roger L., Onland-Moret, N. Charlotte, Peters, Ulrike, Poynter, Jenny N., Rinaldi, Sabina, Robien, Kim, Rohan, Thomas, Sanchez, Maria-Jose, Schairer, Catherine, Schouten, Leo J., Tjonneland, Anne, Townsend, Mary K., Travis, Ruth C., Trichopoulou, Antonia, van den Brandt, Piet A., Vineis, Paolo, Wilkens, Lynne, Wolk, Alicja, Yang, Hannah P., Zeleniuch-Jacquotte, Anne, and Tworoger, Shelley S.
Abstract: Ovarian cancer risk factors differ by histotype; however, within subtype, there is substantial variability in outcomes. We hypothesized that risk factor profiles may influence tumor aggressiveness, defined by time between diagnosis and death, independent of histology. Among 1.3 million women from 21 prospective cohorts, 4,584 invasive epithelial ovarian cancers were identified and classified as highly aggressive (death in <1 year, n = 864), very aggressive (death in 1 to < 3 years, n = 1,390), moderately aggressive (death in 3 to < 5 years, n = 639), and less aggressive (lived 5+ years, n = 1,691). Using competing risks Cox proportional hazards regression, we assessed heterogeneity of associations by tumor aggressiveness for all cases and among serous and endometrioid/clear cell tumors. Associations between parity (phet = 0.01), family history of ovarian cancer (phet = 0.02), body mass index (BMI; phet ≤ 0.04) and smoking (phet < 0.01) and ovarian cancer risk differed by aggressiveness. A first/single pregnancy, relative to nulliparity, was inversely associated with highly aggressive disease (HR: 0.72; 95% CI [0.58–0.88]), no association was observed for subsequent pregnancies (per pregnancy, 0.97 [0.92–1.02]). In contrast, first and subsequent pregnancies were similarly associated with less aggressive disease (0.87 for both). Family history of ovarian cancer was only associated with risk of less aggressive disease (1.94 [1.47–2.55]). High BMI (≥35 vs. 20 to < 25 kg/m2, 1.93 [1.46–2.56] and current smoking (vs. never, 1.30 [1.07–1.57]) were associated with increased risk of highly aggressive disease. Results were similar within histotypes. Ovarian cancer risk factors may be directly associated with subtypes defined by tumor aggressiveness, rather than through differential effects on histology. Studies to assess biological pathways are warranted.
Published: 2019
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24. Analgesic Use and Ovarian Cancer Risk: An Analysis in the Ovarian Cancer Cohort Consortium.

Author: Trabert, Britton, Trabert, Britton, Poole, Elizabeth M, White, Emily, Visvanathan, Kala, Adami, Hans-Olov, Anderson, Garnet L, Brasky, Theodore M, Brinton, Louise A, Fortner, Renee T, Gaudet, Mia, Hartge, Patricia, Hoffman-Bolton, Judith, Jones, Michael, Lacey, James V, Larsson, Susanna C, Mackenzie, Gerardo G, Schouten, Leo J, Sandler, Dale P, O'Brien, Katie, Patel, Alpa V, Peters, Ulrike, Prizment, Anna, Robien, Kim, Setiawan, V Wendy, Swerdlow, Anthony, van den Brandt, Piet A, Weiderpass, Elisabete, Wilkens, Lynne R, Wolk, Alicja, Wentzensen, Nicolas, Tworoger, Shelley S, Ovarian Cancer Cohort Consortium (OC3), Trabert, Britton, Trabert, Britton, Poole, Elizabeth M, White, Emily, Visvanathan, Kala, Adami, Hans-Olov, Anderson, Garnet L, Brasky, Theodore M, Brinton, Louise A, Fortner, Renee T, Gaudet, Mia, Hartge, Patricia, Hoffman-Bolton, Judith, Jones, Michael, Lacey, James V, Larsson, Susanna C, Mackenzie, Gerardo G, Schouten, Leo J, Sandler, Dale P, O'Brien, Katie, Patel, Alpa V, Peters, Ulrike, Prizment, Anna, Robien, Kim, Setiawan, V Wendy, Swerdlow, Anthony, van den Brandt, Piet A, Weiderpass, Elisabete, Wilkens, Lynne R, Wolk, Alicja, Wentzensen, Nicolas, Tworoger, Shelley S, and Ovarian Cancer Cohort Consortium (OC3)
Abstract: BACKGROUND:Aspirin use is associated with reduced risk of several cancers. A pooled analysis of 12 case-control studies showed a 10% decrease in ovarian cancer risk with regular aspirin use, which was stronger for daily and low-dose users. To prospectively investigate associations of analgesic use with ovarian cancer, we analyzed data from 13 studies in the Ovarian Cancer Cohort Consortium (OC3). METHODS:The current study included 758 829 women who at study enrollment self-reported analgesic use, among whom 3514 developed ovarian cancer. Using Cox regression, we assessed associations between frequent medication use and risk of ovarian cancer. Dose and duration were also evaluated. All statistical tests were two-sided. RESULTS:Women who used aspirin almost daily (≥6 days/wk) vs infrequent/nonuse experienced a 10% reduction in ovarian cancer risk (rate ratio [RR] = 0.90, 95% confidence interval [CI] = 0.82 to 1.00, P = .05). Frequent use (≥4 days/wk) of aspirin (RR = 0.95, 95% CI = 0.88 to 1.03), nonaspirin nonsteroidal anti-inflammatory drugs (NSAIDs; RR = 1.00, 95% CI = 0.90 to 1.11), or acetaminophen (RR = 1.05, 95% CI = 0.88 to 1.24) was not associated with risk. Daily acetaminophen use (RR = 1.28, 95% CI = 1.00 to 1.65, P = .05) was associated with elevated ovarian cancer risk. Risk estimates for frequent, long-term (10+ years) use of aspirin (RR = 1.15, 95% CI = 0.98 to 1.34) or nonaspirin NSAIDs (RR = 1.19, 95% CI = 0.84 to 1.68) were modestly elevated, although not statistically significantly so. CONCLUSIONS:This large, prospective analysis suggests that women who use aspirin daily have a slightly lower risk of developing ovarian cancer (∼10% lower than infrequent/nonuse)-similar to the risk reduction observed in case-control analyses. The observed potential elevated risks for 10+ years of frequent aspirin and NSAID use require further study but could be due to confounding by medical indications for use or variation in drug dosing.
Published: 2019

25. High levels of C-reactive protein are associated with an increased risk of ovarian cancer : Results from the Ovarian Cancer Cohort Consortium

Author: Peres, Lauren C, Mallen, Adrianne R, Townsend, Mary K, Poole, Elizabeth M, Trabert, Britton, Allen, Naomi E, Arslan, Alan A, Dossus, Laure, Fortner, Renée T, Gram, Inger T, Hartge, Patricia, Idahl, Annika, Kaaks, Rudolf, Kvaskoff, Marina, Magiocco, Anthony, Merritt, Melissa A, Quirós, J Ramón, Tjonneland, Anne, Trichopoulou, Antonia, Tumino, Rosario, van Gils, Carla, Visvanathan, Kala, Wentzensen, Nicolas, Zeleniuch-Jacquotte, Anne, Tworoger, Shelley S, Peres, Lauren C, Mallen, Adrianne R, Townsend, Mary K, Poole, Elizabeth M, Trabert, Britton, Allen, Naomi E, Arslan, Alan A, Dossus, Laure, Fortner, Renée T, Gram, Inger T, Hartge, Patricia, Idahl, Annika, Kaaks, Rudolf, Kvaskoff, Marina, Magiocco, Anthony, Merritt, Melissa A, Quirós, J Ramón, Tjonneland, Anne, Trichopoulou, Antonia, Tumino, Rosario, van Gils, Carla, Visvanathan, Kala, Wentzensen, Nicolas, Zeleniuch-Jacquotte, Anne, and Tworoger, Shelley S
Published: 2019

26. Ovarian cancer risk factors by tumor aggressiveness: An analysis from the Ovarian Cancer Cohort Consortium

Author: Fortner, Renee T., Fortner, Renee T., Poole, Elizabeth M., Wentzensen, Nicolas A., Trabert, Britton, White, Emily, Arslan, Alan A., Patel, Alpa, Setiawan, V. Wendy, Visvanathan, Kala, Weiderpass, Elisabete, Adami, Hans-Olov, Black, Amanda, Bernstein, Leslie, Brinton, Louise A., Buring, Julie, Clendenen, Tess, Fournier, Agnes, Fraser, Gary, Gapstur, Susan M., Gaudet, Mia M., Giles, Graham G., Gram, Inger T., Hartge, Patricia, Hoffman-Bolton, Judith, Idahl, Annika, Kaaks, Rudolf, Kirsh, Victoria A., Knutsen, Synnove, Koh, Woon-Puay, Lacey, James V., Lee, I-Min, Lundin, Eva, Merritt, Melissa A., Milne, Roger L., Onland-Moret, N. Charlotte, Peters, Ulrike, Poynter, Jenny N., Rinaldi, Sabina, Robien, Kim, Rohan, Thomas, Sanchez, Maria-Jose, Schairer, Catherine, Schouten, Leo J., Tjonneland, Anne, Townsend, Mary K., Travis, Ruth C., Trichopoulou, Antonia, van den Brandt, Piet A., Vineis, Paolo, Wilkens, Lynne, Wolk, Alicja, Yang, Hannah P., Zeleniuch-Jacquotte, Anne, Tworoger, Shelley S., Fortner, Renee T., Fortner, Renee T., Poole, Elizabeth M., Wentzensen, Nicolas A., Trabert, Britton, White, Emily, Arslan, Alan A., Patel, Alpa, Setiawan, V. Wendy, Visvanathan, Kala, Weiderpass, Elisabete, Adami, Hans-Olov, Black, Amanda, Bernstein, Leslie, Brinton, Louise A., Buring, Julie, Clendenen, Tess, Fournier, Agnes, Fraser, Gary, Gapstur, Susan M., Gaudet, Mia M., Giles, Graham G., Gram, Inger T., Hartge, Patricia, Hoffman-Bolton, Judith, Idahl, Annika, Kaaks, Rudolf, Kirsh, Victoria A., Knutsen, Synnove, Koh, Woon-Puay, Lacey, James V., Lee, I-Min, Lundin, Eva, Merritt, Melissa A., Milne, Roger L., Onland-Moret, N. Charlotte, Peters, Ulrike, Poynter, Jenny N., Rinaldi, Sabina, Robien, Kim, Rohan, Thomas, Sanchez, Maria-Jose, Schairer, Catherine, Schouten, Leo J., Tjonneland, Anne, Townsend, Mary K., Travis, Ruth C., Trichopoulou, Antonia, van den Brandt, Piet A., Vineis, Paolo, Wilkens, Lynne, Wolk, Alicja, Yang, Hannah P., Zeleniuch-Jacquotte, Anne, and Tworoger, Shelley S.
Abstract: Ovarian cancer risk factors differ by histotype; however, within subtype, there is substantial variability in outcomes. We hypothesized that risk factor profiles may influence tumor aggressiveness, defined by time between diagnosis and death, independent of histology. Among 1.3 million women from 21 prospective cohorts, 4,584 invasive epithelial ovarian cancers were identified and classified as highly aggressive (death in = 35 vs. 20 to <25 kg/m(2), 1.93 [1.46-2.56] and current smoking (vs. never, 1.30 [1.07-1.57]) were associated with increased risk of highly aggressive disease. Results were similar within histotypes. Ovarian cancer risk factors may be directly associated with subtypes defined by tumor aggressiveness, rather than through differential effects on histology. Studies to assess biological pathways are warranted.
Published: 2019

27. High levels of C-reactive protein are associated with an increased risk of ovarian cancer : Results from the Ovarian Cancer Cohort Consortium

Author: Peres, Lauren C, Mallen, Adrianne R, Townsend, Mary K, Poole, Elizabeth M, Trabert, Britton, Allen, Naomi E, Arslan, Alan A, Dossus, Laure, Fortner, Renée T, Gram, Inger T, Hartge, Patricia, Idahl, Annika, Kaaks, Rudolf, Kvaskoff, Marina, Magiocco, Anthony, Merritt, Melissa A, Quirós, J Ramón, Tjonneland, Anne, Trichopoulou, Antonia, Tumino, Rosario, van Gils, Carla, Visvanathan, Kala, Wentzensen, Nicolas, Zeleniuch-Jacquotte, Anne, Tworoger, Shelley S, Peres, Lauren C, Mallen, Adrianne R, Townsend, Mary K, Poole, Elizabeth M, Trabert, Britton, Allen, Naomi E, Arslan, Alan A, Dossus, Laure, Fortner, Renée T, Gram, Inger T, Hartge, Patricia, Idahl, Annika, Kaaks, Rudolf, Kvaskoff, Marina, Magiocco, Anthony, Merritt, Melissa A, Quirós, J Ramón, Tjonneland, Anne, Trichopoulou, Antonia, Tumino, Rosario, van Gils, Carla, Visvanathan, Kala, Wentzensen, Nicolas, Zeleniuch-Jacquotte, Anne, and Tworoger, Shelley S
Published: 2019

28. High Levels of C-Reactive Protein Are Associated with an Increased Risk of Ovarian Cancer : Results from the Ovarian Cancer Cohort Consortium

Author: Peres, Lauren C, Mallen, Adrianne R, Townsend, Mary K, Poole, Elizabeth M, Trabert, Britton, Allen, Naomi E, Arslan, Alan A, Dossus, Laure, Fortner, Renée T, Gram, Inger T, Hartge, Patricia, Idahl, Annika, Kaaks, Rudolf, Kvaskoff, Marina, Magliocco, Anthony M, Merritt, Melissa A, Quirós, J Ramón, Tjonneland, Anne, Trichopoulou, Antonia, Tumino, Rosario, van Gils, Carla H, Visvanathan, Kala, Wentzensen, Nicolas, Zeleniuch-Jacquotte, Anne, Tworoger, Shelley S, Peres, Lauren C, Mallen, Adrianne R, Townsend, Mary K, Poole, Elizabeth M, Trabert, Britton, Allen, Naomi E, Arslan, Alan A, Dossus, Laure, Fortner, Renée T, Gram, Inger T, Hartge, Patricia, Idahl, Annika, Kaaks, Rudolf, Kvaskoff, Marina, Magliocco, Anthony M, Merritt, Melissa A, Quirós, J Ramón, Tjonneland, Anne, Trichopoulou, Antonia, Tumino, Rosario, van Gils, Carla H, Visvanathan, Kala, Wentzensen, Nicolas, Zeleniuch-Jacquotte, Anne, and Tworoger, Shelley S
Abstract: Growing epidemiologic evidence supports chronic inflammation as a mechanism of ovarian carcinogenesis. An association between a circulating marker of inflammation, C-reactive protein (CRP), and ovarian cancer risk has been consistently observed, yet, potential heterogeneity of this association by tumor and patient characteristics has not been adequately explored. In this study, we pooled data from case-control studies nested within six cohorts in the Ovarian Cancer Cohort Consortium (OC3) to examine the association between CRP and epithelial ovarian cancer risk overall, by histologic subtype and by participant characteristics. CRP concentrations were measured from prediagnosis serum or plasma in 1,091 cases and 1,951 controls. Multivariable conditional logistic regression was used to estimate ORs and 95% confidence intervals (CI). When CRP was evaluated using tertiles, no associations with ovarian cancer risk were observed. A 67% increased ovarian cancer risk was found for women with CRP concentrations >10 mg/L compared with <1 mg/L (OR = 1.67; 95% CI = 1.12-2.48). A CRP concentration >10 mg/L was positively associated with risk of mucinous (OR = 9.67; 95% CI = 1.10-84.80) and endometrioid carcinoma (OR = 3.41; 95% CI = 1.07-10.92), and suggestively positive, although not statistically significant, for serous (OR = 1.43; 95% CI = 0.82-2.49) and clear cell carcinoma (OR = 2.05; 95% CI = 0.36-11.57; P heterogeneity = 0.20). Heterogeneity was observed with oral contraceptive use (P interaction = 0.03), where the increased risk was present only among ever users (OR = 3.24; 95% CI = 1.62-6.47). This study adds to the existing evidence that CRP plays a role in ovarian carcinogenesis and suggests that inflammation may be particularly implicated in the etiology of endometrioid and mucinous carcinoma. SIGNIFICANCE: C-reactive protein is involved in ovarian carcinogenesis, and chronic inflammation may be particularly implicated in the etiology of mucinous and endomet
Published: 2019
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29. High Levels of C-Reactive Protein Are Associated with an Increased Risk of Ovarian Cancer : Results from the Ovarian Cancer Cohort Consortium

Author: Peres, Lauren C., Mallen, Adrianne R., Townsend, Mary K., Poole, Elizabeth M., Trabert, Britton, Allen, Naomi E., Arslan, Alan A., Dossus, Laure, Fortner, Renee T., Gram, Inger T., Hartge, Patricia, Idahl, Annika, Kaaks, Rudolf, Kvaskoff, Marina, Magliocco, Anthony M., Merritt, Melissa A., Quiros, J. Ramon, Tjonneland, Anne, Trichopoulou, Antonia, Tumino, Rosario, van Gils, Carla H., Visvanathan, Kala, Wentzensen, Nicolas, Zeleniuch-Jacquotte, Anne, Tworoger, Shelley S., Peres, Lauren C., Mallen, Adrianne R., Townsend, Mary K., Poole, Elizabeth M., Trabert, Britton, Allen, Naomi E., Arslan, Alan A., Dossus, Laure, Fortner, Renee T., Gram, Inger T., Hartge, Patricia, Idahl, Annika, Kaaks, Rudolf, Kvaskoff, Marina, Magliocco, Anthony M., Merritt, Melissa A., Quiros, J. Ramon, Tjonneland, Anne, Trichopoulou, Antonia, Tumino, Rosario, van Gils, Carla H., Visvanathan, Kala, Wentzensen, Nicolas, Zeleniuch-Jacquotte, Anne, and Tworoger, Shelley S.
Abstract: Growing epidemiologic evidence supports chronic inflammation as a mechanism of ovarian carcinogenesis. An association between a circulating marker of inflammation, C-reactive protein (CRP), and ovarian cancer risk has been consistently observed, yet, potential heterogeneity of this association by tumor and patient characteristics has not been adequately explored. In this study, we pooled data from case-control studies nested within six cohorts in the Ovarian Cancer Cohort Consortium (OC3) to examine the association between CRP and epithelial ovarian cancer risk overall, by histologic subtype and by participant characteristics. CRP concentrations were measured from prediagnosis serum or plasma in 1,091 cases and 1,951 controls. Multivariable conditional logistic regression was used to estimate ORs and 95% confidence intervals (CI). When CRP was evaluated using tertiles, no associations with ovarian cancer risk were observed. A 67% increased ovarian cancer risk was found for women with CRP concentrations >10 mg/L compared with <1 mg/L (OR = 1.67; 95% CI = 1.12-2.48). A CRP concentration >10 mg/L was positively associated with risk of mucinous (OR = 9.67; 95% CI = 1.10-84.80) and endometrioid carcinoma (OR = 3.41; 95% CI = 1.07-10.92), and suggestively positive, although not statistically significant, for serous (OR = 1.43; 95% CI = 0.82-2.49) and clear cell carcinoma (OR = 2.05; 95% CI = 0.36-11.57; P-heterogeneity = 0.20). Heterogeneity was observed with oral contraceptive use (P-interaction = 0.03), where the increased risk was present only among ever users (OR = 3.24; 95% CI = 1.62-6.47). This study adds to the existing evidence that CRP plays a role in ovarian carcinogenesis and suggests that inflammation may be particularly implicated in the etiology of endometrioid and mucinous carcinoma. Significance: C-reactive protein is involved in ovarian carcinogenesis, and chronic inflammation may be particularly implicated in the etiology of mucinous and endomet
Published: 2019
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30. Antibodies Against Chlamydia trachomatis and Ovarian Cancer Risk in Two Independent Populations

Author: Trabert, Britton, Waterboer, Tim, Idahl, Annika, Brenner, Nicole, Brinton, Louise A., Butt, Julia, Coburn, Sally B., Hartge, Patricia, Hufnagel, Katrin, Inturrisi, Federica, Lissowska, Jolanta, Mentzer, Alexander, Peplonska, Beata, Sherman, Mark E., Wills, Gillian S., Woodhall, Sarah C., Pawlita, Michael, Wentzensen, Nicolas, Trabert, Britton, Waterboer, Tim, Idahl, Annika, Brenner, Nicole, Brinton, Louise A., Butt, Julia, Coburn, Sally B., Hartge, Patricia, Hufnagel, Katrin, Inturrisi, Federica, Lissowska, Jolanta, Mentzer, Alexander, Peplonska, Beata, Sherman, Mark E., Wills, Gillian S., Woodhall, Sarah C., Pawlita, Michael, and Wentzensen, Nicolas
Abstract: Background: Pelvic inflammatory disease (PID) has been associated with ovarian cancer risk. To clarify the role of Chlamydia trachomatis and other infectious agents in the development of ovarian cancer, we evaluated the association of serologic markers with incident ovarian cancer using a staged approach in two independent populations. Methods: Studies included: 1) a case-control study in Poland (244 ovarian cancers/556 control subjects) and 2) a prospective nested case-control study in the PLCO Cancer Screening Trial (160 ovarian cancers/159 control subjects). Associations of serologic marker levels with ovarian cancer risk at diagnostic as well as higher thresholds, identified in Poland and independently evaluated in PLCO, were estimated using multivariable adjusted logistic regression. Results: In the Polish study, antibodies (based on laboratory cut-point) against the chlamydia plasmid-encoded Pgp3 protein (serological gold standard) were associated with increased ovarian cancer risk (adjusted odds ratio [OR] = 1.63, 95% confidence interval [CI] = 1.20 to 2.22); when a positive result was redefined at higher levels, ovarian cancer risk was increased (cut-point 2: OR = 2.00, 95% CI = 1.38 to 2.89; cut-point 3 [max OR]: OR = 2.19, 95% CI = 1.29 to 3.73). In the prospective PLCO study, Pgp3 antibodies were associated with elevated risk at the laboratory cut-point (OR = 1.43, 95% CI = 0.78 to 2.63) and more stringent cut-points (cut-point 2: OR = 2.25, 95% CI = 1.07 to 4.71); cut-point 3: OR = 2.53, 95% CI = 0.63 to 10.08). In both studies, antibodies against other infectious agents measured were not associated with risk. Conclusions: In two independent populations, antibodies against prior/current C. trachomatis (Pgp3) were associated with a doubling in ovarian cancer risk, whereas markers of other infectious agents were unrelated. These findings lend support for an association between PID and ovarian cancer.
Published: 2019
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31. Analgesic Use and Ovarian Cancer Risk: An Analysis in the Ovarian Cancer Cohort Consortium.

Author: Trabert, Britton, Trabert, Britton, Poole, Elizabeth M, White, Emily, Visvanathan, Kala, Adami, Hans-Olov, Anderson, Garnet L, Brasky, Theodore M, Brinton, Louise A, Fortner, Renee T, Gaudet, Mia, Hartge, Patricia, Hoffman-Bolton, Judith, Jones, Michael, Lacey, James V, Larsson, Susanna C, Mackenzie, Gerardo G, Schouten, Leo J, Sandler, Dale P, O'Brien, Katie, Patel, Alpa V, Peters, Ulrike, Prizment, Anna, Robien, Kim, Setiawan, V Wendy, Swerdlow, Anthony, van den Brandt, Piet A, Weiderpass, Elisabete, Wilkens, Lynne R, Wolk, Alicja, Wentzensen, Nicolas, Tworoger, Shelley S, Ovarian Cancer Cohort Consortium (OC3), Trabert, Britton, Trabert, Britton, Poole, Elizabeth M, White, Emily, Visvanathan, Kala, Adami, Hans-Olov, Anderson, Garnet L, Brasky, Theodore M, Brinton, Louise A, Fortner, Renee T, Gaudet, Mia, Hartge, Patricia, Hoffman-Bolton, Judith, Jones, Michael, Lacey, James V, Larsson, Susanna C, Mackenzie, Gerardo G, Schouten, Leo J, Sandler, Dale P, O'Brien, Katie, Patel, Alpa V, Peters, Ulrike, Prizment, Anna, Robien, Kim, Setiawan, V Wendy, Swerdlow, Anthony, van den Brandt, Piet A, Weiderpass, Elisabete, Wilkens, Lynne R, Wolk, Alicja, Wentzensen, Nicolas, Tworoger, Shelley S, and Ovarian Cancer Cohort Consortium (OC3)
Abstract: BACKGROUND:Aspirin use is associated with reduced risk of several cancers. A pooled analysis of 12 case-control studies showed a 10% decrease in ovarian cancer risk with regular aspirin use, which was stronger for daily and low-dose users. To prospectively investigate associations of analgesic use with ovarian cancer, we analyzed data from 13 studies in the Ovarian Cancer Cohort Consortium (OC3). METHODS:The current study included 758 829 women who at study enrollment self-reported analgesic use, among whom 3514 developed ovarian cancer. Using Cox regression, we assessed associations between frequent medication use and risk of ovarian cancer. Dose and duration were also evaluated. All statistical tests were two-sided. RESULTS:Women who used aspirin almost daily (≥6 days/wk) vs infrequent/nonuse experienced a 10% reduction in ovarian cancer risk (rate ratio [RR] = 0.90, 95% confidence interval [CI] = 0.82 to 1.00, P = .05). Frequent use (≥4 days/wk) of aspirin (RR = 0.95, 95% CI = 0.88 to 1.03), nonaspirin nonsteroidal anti-inflammatory drugs (NSAIDs; RR = 1.00, 95% CI = 0.90 to 1.11), or acetaminophen (RR = 1.05, 95% CI = 0.88 to 1.24) was not associated with risk. Daily acetaminophen use (RR = 1.28, 95% CI = 1.00 to 1.65, P = .05) was associated with elevated ovarian cancer risk. Risk estimates for frequent, long-term (10+ years) use of aspirin (RR = 1.15, 95% CI = 0.98 to 1.34) or nonaspirin NSAIDs (RR = 1.19, 95% CI = 0.84 to 1.68) were modestly elevated, although not statistically significantly so. CONCLUSIONS:This large, prospective analysis suggests that women who use aspirin daily have a slightly lower risk of developing ovarian cancer (∼10% lower than infrequent/nonuse)-similar to the risk reduction observed in case-control analyses. The observed potential elevated risks for 10+ years of frequent aspirin and NSAID use require further study but could be due to confounding by medical indications for use or variation in drug dosing.
Published: 2019

32. High levels of C-reactive protein are associated with an increased risk of ovarian cancer : Results from the Ovarian Cancer Cohort Consortium

Author: Peres, Lauren C, Mallen, Adrianne R, Townsend, Mary K, Poole, Elizabeth M, Trabert, Britton, Allen, Naomi E, Arslan, Alan A, Dossus, Laure, Fortner, Renée T, Gram, Inger T, Hartge, Patricia, Idahl, Annika, Kaaks, Rudolf, Kvaskoff, Marina, Magiocco, Anthony, Merritt, Melissa A, Quirós, J Ramón, Tjonneland, Anne, Trichopoulou, Antonia, Tumino, Rosario, van Gils, Carla, Visvanathan, Kala, Wentzensen, Nicolas, Zeleniuch-Jacquotte, Anne, Tworoger, Shelley S, Peres, Lauren C, Mallen, Adrianne R, Townsend, Mary K, Poole, Elizabeth M, Trabert, Britton, Allen, Naomi E, Arslan, Alan A, Dossus, Laure, Fortner, Renée T, Gram, Inger T, Hartge, Patricia, Idahl, Annika, Kaaks, Rudolf, Kvaskoff, Marina, Magiocco, Anthony, Merritt, Melissa A, Quirós, J Ramón, Tjonneland, Anne, Trichopoulou, Antonia, Tumino, Rosario, van Gils, Carla, Visvanathan, Kala, Wentzensen, Nicolas, Zeleniuch-Jacquotte, Anne, and Tworoger, Shelley S
Published: 2019

33. High levels of C-reactive protein are associated with an increased risk of ovarian cancer: Results from the Ovarian Cancer Cohort Consortium

Author: Epi Kanker Team A, Cancer, JC onderzoeksprogramma Kanker, Peres, Lauren C, Mallen, Adrianne R, Townsend, Mary K, Poole, Elizabeth M, Trabert, Britton, Allen, Naomi E, Arslan, Alan A, Dossus, Laure, Fortner, Renée T, Gram, Inger T, Hartge, Patricia, Idahl, Annika, Kaaks, Rudolf, Kvaskoff, Marina, Magiocco, Anthony, Merritt, Melissa A, Quirós, J Ramón, Tjonneland, Anne, Trichopoulou, Antonia, Tumino, Rosario, van Gils, Carla, Visvanathan, Kala, Wentzensen, Nicolas, Zeleniuch-Jacquotte, Anne, Tworoger, Shelley S, Epi Kanker Team A, Cancer, JC onderzoeksprogramma Kanker, Peres, Lauren C, Mallen, Adrianne R, Townsend, Mary K, Poole, Elizabeth M, Trabert, Britton, Allen, Naomi E, Arslan, Alan A, Dossus, Laure, Fortner, Renée T, Gram, Inger T, Hartge, Patricia, Idahl, Annika, Kaaks, Rudolf, Kvaskoff, Marina, Magiocco, Anthony, Merritt, Melissa A, Quirós, J Ramón, Tjonneland, Anne, Trichopoulou, Antonia, Tumino, Rosario, van Gils, Carla, Visvanathan, Kala, Wentzensen, Nicolas, Zeleniuch-Jacquotte, Anne, and Tworoger, Shelley S
Published: 2019

34. Analgesic Use and Ovarian Cancer Risk: An Analysis in the Ovarian Cancer Cohort Consortium

Author: Trabert, Britton, Poole, Elizabeth M., White, Emily, Visvanathan, Kala, Adami, Hans-Olov, Anderson, Garnet L., Brasky, Theodore M., Brinton, Louise A., Fortner, Renee T., Gaudet, Mia, Hartge, Patricia, Hoffman-Bolton, Judith, Jones, Michael, Lacey, James V., Larsson, Susanna C., Mackenzie, Gerardo G., Schouten, Leo J., Sandler, Dale P., O'Brien, Katie, Patel, Alpa V., Peters, Ulrike, Prizment, Anna, Robien, Kim, Setiawan, V. Wendy, Swerdlow, Anthony, van den Brandt, Piet A., Weiderpass, Elisabete, Wilkens, Lynne R., Wolk, Alicja, Wentzensen, Nicolas, Tworoger, Shelley S., Ovarian Cancer Cohort Consortium OC3, Trabert, Britton, Poole, Elizabeth M., White, Emily, Visvanathan, Kala, Adami, Hans-Olov, Anderson, Garnet L., Brasky, Theodore M., Brinton, Louise A., Fortner, Renee T., Gaudet, Mia, Hartge, Patricia, Hoffman-Bolton, Judith, Jones, Michael, Lacey, James V., Larsson, Susanna C., Mackenzie, Gerardo G., Schouten, Leo J., Sandler, Dale P., O'Brien, Katie, Patel, Alpa V., Peters, Ulrike, Prizment, Anna, Robien, Kim, Setiawan, V. Wendy, Swerdlow, Anthony, van den Brandt, Piet A., Weiderpass, Elisabete, Wilkens, Lynne R., Wolk, Alicja, Wentzensen, Nicolas, Tworoger, Shelley S., and Ovarian Cancer Cohort Consortium OC3
Abstract: Background Aspirin use is associated with reduced risk of several cancers. A pooled analysis of 12 case-control studies showed a 10% decrease in ovarian cancer risk with regular aspirin use, which was stronger for daily and low-dose users. To prospectively investigate associations of analgesic use with ovarian cancer, we analyzed data from 13 studies in the Ovarian Cancer Cohort Consortium (OC3).Methods The current study included 758 829 women who at study enrollment self-reported analgesic use, among whom 3514 developed ovarian cancer. Using Cox regression, we assessed associations between frequent medication use and risk of ovarian cancer. Dose and duration were also evaluated. All statistical tests were two-sided.Results Women who used aspirin almost daily (6 days/wk) vs infrequent/nonuse experienced a 10% reduction in ovarian cancer risk (rate ratio [RR] = 0.90, 95% confidence interval [CI] = 0.82 to 1.00, P = .05). Frequent use (4 days/wk) of aspirin (RR = 0.95, 95% CI = 0.88 to 1.03), nonaspirin nonsteroidal anti-inflammatory drugs (NSAIDs; RR = 1.00, 95% CI = 0.90 to 1.11), or acetaminophen (RR = 1.05, 95% CI = 0.88 to 1.24) was not associated with risk. Daily acetaminophen use (RR = 1.28, 95% CI = 1.00 to 1.65, P = .05) was associated with elevated ovarian cancer risk. Risk estimates for frequent, long-term (10+ years) use of aspirin (RR = 1.15, 95% CI = 0.98 to 1.34) or nonaspirin NSAIDs (RR = 1.19, 95% CI = 0.84 to 1.68) were modestly elevated, although not statistically significantly so.Conclusions This large, prospective analysis suggests that women who use aspirin daily have a slightly lower risk of developing ovarian cancer (approximate to 10% lower than infrequent/nonuse)similar to the risk reduction observed in case-control analyses. The observed potential elevated risks for 10+ years of frequent aspirin and NSAID use require further study but could be due to confounding by medical indications for use or variation in drug dosi
Published: 2019

35. Ovarian cancer risk factors by tumor aggressiveness: An analysis from the Ovarian Cancer Cohort Consortium

Author: Fortner, Renee T., Poole, Elizabeth M., Wentzensen, Nicolas A., Trabert, Britton, White, Emily, Arslan, Alan A., Patel, Alpa, Setiawan, V. Wendy, Visvanathan, Kala, Weiderpass, Elisabete, Adami, Hans-Olov, Black, Amanda, Bernstein, Leslie, Brinton, Louise A., Buring, Julie, Clendenen, Tess, Fournier, Agnes, Fraser, Gary, Gapstur, Susan M., Gaudet, Mia M., Giles, Graham G., Gram, Inger T., Hartge, Patricia, Hoffman-Bolton, Judith, Idahl, Annika, Kaaks, Rudolf, Kirsh, Victoria A., Knutsen, Synnove, Koh, Woon-Puay, Lacey, James V., Lee, I-Min, Lundin, Eva, Merritt, Melissa A., Milne, Roger L., Onland-Moret, N. Charlotte, Peters, Ulrike, Poynter, Jenny N., Rinaldi, Sabina, Robien, Kim, Rohan, Thomas, Sanchez, Maria-Jose, Schairer, Catherine, Schouten, Leo J., Tjonneland, Anne, Townsend, Mary K., Travis, Ruth C., Trichopoulou, Antonia, van den Brandt, Piet A., Vineis, Paolo, Wilkens, Lynne, Wolk, Alicja, Yang, Hannah P., Zeleniuch-Jacquotte, Anne, Tworoger, Shelley S., Fortner, Renee T., Poole, Elizabeth M., Wentzensen, Nicolas A., Trabert, Britton, White, Emily, Arslan, Alan A., Patel, Alpa, Setiawan, V. Wendy, Visvanathan, Kala, Weiderpass, Elisabete, Adami, Hans-Olov, Black, Amanda, Bernstein, Leslie, Brinton, Louise A., Buring, Julie, Clendenen, Tess, Fournier, Agnes, Fraser, Gary, Gapstur, Susan M., Gaudet, Mia M., Giles, Graham G., Gram, Inger T., Hartge, Patricia, Hoffman-Bolton, Judith, Idahl, Annika, Kaaks, Rudolf, Kirsh, Victoria A., Knutsen, Synnove, Koh, Woon-Puay, Lacey, James V., Lee, I-Min, Lundin, Eva, Merritt, Melissa A., Milne, Roger L., Onland-Moret, N. Charlotte, Peters, Ulrike, Poynter, Jenny N., Rinaldi, Sabina, Robien, Kim, Rohan, Thomas, Sanchez, Maria-Jose, Schairer, Catherine, Schouten, Leo J., Tjonneland, Anne, Townsend, Mary K., Travis, Ruth C., Trichopoulou, Antonia, van den Brandt, Piet A., Vineis, Paolo, Wilkens, Lynne, Wolk, Alicja, Yang, Hannah P., Zeleniuch-Jacquotte, Anne, and Tworoger, Shelley S.
Abstract: Ovarian cancer risk factors differ by histotype; however, within subtype, there is substantial variability in outcomes. We hypothesized that risk factor profiles may influence tumor aggressiveness, defined by time between diagnosis and death, independent of histology. Among 1.3 million women from 21 prospective cohorts, 4,584 invasive epithelial ovarian cancers were identified and classified as highly aggressive (death in = 35 vs. 20 to <25 kg/m(2), 1.93 [1.46-2.56] and current smoking (vs. never, 1.30 [1.07-1.57]) were associated with increased risk of highly aggressive disease. Results were similar within histotypes. Ovarian cancer risk factors may be directly associated with subtypes defined by tumor aggressiveness, rather than through differential effects on histology. Studies to assess biological pathways are warranted.
Published: 2019

36. High Levels of C-Reactive Protein Are Associated with an Increased Risk of Ovarian Cancer: Results from the Ovarian Cancer Cohort Consortium

Author: Peres, Lauren C., Mallen, Adrianne R., Townsend, Mary K., Poole, Elizabeth M., Trabert, Britton, Allen, Naomi E., Arslan, Alan A., Dossus, Laure, Fortner, Renee T., Gram, Inger T., Hartge, Patricia, Idahl, Annika, Kaaks, Rudolf, Kvaskoff, Marina, Magliocco, Anthony M., Merritt, Melissa A., Quiros, J. Ramon, Tjønneland, Anne, Trichopoulou, Antonia, Tumino, Rosario, van Gils, Carla H., Visvanathan, Kala, Wentzensen, Nicolas, Zeleniuch-Jacquotte, Anne, Tworoger, Shelley S., Peres, Lauren C., Mallen, Adrianne R., Townsend, Mary K., Poole, Elizabeth M., Trabert, Britton, Allen, Naomi E., Arslan, Alan A., Dossus, Laure, Fortner, Renee T., Gram, Inger T., Hartge, Patricia, Idahl, Annika, Kaaks, Rudolf, Kvaskoff, Marina, Magliocco, Anthony M., Merritt, Melissa A., Quiros, J. Ramon, Tjønneland, Anne, Trichopoulou, Antonia, Tumino, Rosario, van Gils, Carla H., Visvanathan, Kala, Wentzensen, Nicolas, Zeleniuch-Jacquotte, Anne, and Tworoger, Shelley S.
Published: 2019

37. Analgesic Use and Ovarian Cancer Risk : An Analysis in the Ovarian Cancer Cohort Consortium.

Author: Trabert, Britton, Poole, Elizabeth M, White, Emily, Visvanathan, Kala, Adami, Hans-Olov, Anderson, Garnet L, Brasky, Theodore M, Brinton, Louise A, Fortner, Renee T, Gaudet, Mia, Hartge, Patricia, Hoffman-Bolton, Judith, Jones, Michael, Lacey, James V, Larsson, Susanna C, Mackenzie, Gerardo G, Schouten, Leo J, Sandler, Dale P, O'Brien, Katie, Patel, Alpa V, Peters, Ulrike, Prizment, Anna, Robien, Kim, Setiawan, V Wendy, Swerdlow, Anthony, van den Brandt, Piet A, Weiderpass, Elisabete, Wilkens, Lynne R, Wolk, Alicja, Wentzensen, Nicolas, Tworoger, Shelley S, Trabert, Britton, Poole, Elizabeth M, White, Emily, Visvanathan, Kala, Adami, Hans-Olov, Anderson, Garnet L, Brasky, Theodore M, Brinton, Louise A, Fortner, Renee T, Gaudet, Mia, Hartge, Patricia, Hoffman-Bolton, Judith, Jones, Michael, Lacey, James V, Larsson, Susanna C, Mackenzie, Gerardo G, Schouten, Leo J, Sandler, Dale P, O'Brien, Katie, Patel, Alpa V, Peters, Ulrike, Prizment, Anna, Robien, Kim, Setiawan, V Wendy, Swerdlow, Anthony, van den Brandt, Piet A, Weiderpass, Elisabete, Wilkens, Lynne R, Wolk, Alicja, Wentzensen, Nicolas, and Tworoger, Shelley S
Abstract: Background: Aspirin use is associated with reduced risk of several cancers. A pooled analysis of 12 case-control studies showed a 10% decrease in ovarian cancer risk with regular aspirin use, which was stronger for daily and low-dose users. To prospectively investigate associations of analgesic use with ovarian cancer, we analyzed data from 13 studies in the Ovarian Cancer Cohort Consortium (OC3). Methods: The current study included 758 829 women who at study enrollment self-reported analgesic use, among whom 3514 developed ovarian cancer. Using Cox regression, we assessed associations between frequent medication use and risk of ovarian cancer. Dose and duration were also evaluated. All statistical tests were two-sided. Results: Women who used aspirin almost daily (≥6 days/wk) vs infrequent/nonuse experienced a 10% reduction in ovarian cancer risk (rate ratio [RR] = 0.90, 95% confidence interval [CI] = 0.82 to 1.00, P = .05). Frequent use (≥4 days/wk) of aspirin (RR = 0.95, 95% CI = 0.88 to 1.03), nonaspirin nonsteroidal anti-inflammatory drugs (NSAIDs; RR = 1.00, 95% CI = 0.90 to 1.11), or acetaminophen (RR = 1.05, 95% CI = 0.88 to 1.24) was not associated with risk. Daily acetaminophen use (RR = 1.28, 95% CI = 1.00 to 1.65, P = .05) was associated with elevated ovarian cancer risk. Risk estimates for frequent, long-term (10+ years) use of aspirin (RR = 1.15, 95% CI = 0.98 to 1.34) or nonaspirin NSAIDs (RR = 1.19, 95% CI = 0.84 to 1.68) were modestly elevated, although not statistically significantly so. Conclusions: This large, prospective analysis suggests that women who use aspirin daily have a slightly lower risk of developing ovarian cancer (∼10% lower than infrequent/nonuse)-similar to the risk reduction observed in case-control analyses. The observed potential elevated risks for 10+ years of frequent aspirin and NSAID use require further study but could be due to confounding by medical indications for use or variation in drug dosing.
Published: 2018
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38. HLA Class I and II Diversity Contributes to the Etiologic Heterogeneity of Non-Hodgkin Lymphoma Subtypes

Author: Wang, Sophia S., Carrington, Mary, Berndt, Sonja I., Slager, Susan L., Bracci, Paige M., Voutsinas, Jenna, Cerhan, James R., Smedby, Karin E., Hjalgrim, Henrik, Vijai, Joseph, Morton, Lindsay M., Vermeulen, Roel, Paltiel, Ora, Vajdic, Claire M., Linet, Martha S., Nieters, Alexandra, de Sanjose, Silvia, Cozen, Wendy, Brown, Elizabeth E., Turner, Jennifer, Spinelli, John J., Zheng, Tongzhang, Birmann, Brenda M., Flowers, Christopher R., Becker, Nikolaus, Holly, Elizabeth A., Kane, Eleanor, Weisenburger, Dennis, Maynadie, Marc, Cocco, Pierluigi, Albanes, Demetrius, Weinstein, Stephanie J., Teras, Lauren R., Diver, W. Ryan, Lax, Stephanie J., Travis, Ruth C., Kaaks, Rudolph, Riboli, Elio, Benavente, Yolanda, Brennan, Paul, McKay, James, Delfau-Larue, Marie-Helene, Link, Brian K., Magnani, Corrado, Ennas, Maria Grazia, Latte, Giancarlo, Feldman, Andrew L., Doo, Nicole Wong, Giles, Graham G., Southey, Melissa C., Milne, Roger L., Offit, Kenneth, Musinsky, Jacob, Arslan, Alan A., Purdue, Mark P., Adami, Hans-Olov, Melbye, Mads, Glimelius, Bengt, Conde, Lucia, Camp, Nicola J., Glenn, Martha, Curtin, Karen, Clavel, Jacqueline, Monnereau, Alain, Cox, David G., Ghesquieres, Herve, Salles, Gilles, Bofetta, Paulo, Foretova, Lenka, Staines, Anthony, Davis, Scott, Severson, Richard K., Lan, Qing, Brooks-Wilson, Angela, Smith, Martyn T., Roman, Eve, Kricker, Anne, Zhang, Yawei, Kraft, Peter, Chanock, Stephen J., Rothman, Nathaniel, Hartge, Patricia, Skibola, Christine F., Wang, Sophia S., Carrington, Mary, Berndt, Sonja I., Slager, Susan L., Bracci, Paige M., Voutsinas, Jenna, Cerhan, James R., Smedby, Karin E., Hjalgrim, Henrik, Vijai, Joseph, Morton, Lindsay M., Vermeulen, Roel, Paltiel, Ora, Vajdic, Claire M., Linet, Martha S., Nieters, Alexandra, de Sanjose, Silvia, Cozen, Wendy, Brown, Elizabeth E., Turner, Jennifer, Spinelli, John J., Zheng, Tongzhang, Birmann, Brenda M., Flowers, Christopher R., Becker, Nikolaus, Holly, Elizabeth A., Kane, Eleanor, Weisenburger, Dennis, Maynadie, Marc, Cocco, Pierluigi, Albanes, Demetrius, Weinstein, Stephanie J., Teras, Lauren R., Diver, W. Ryan, Lax, Stephanie J., Travis, Ruth C., Kaaks, Rudolph, Riboli, Elio, Benavente, Yolanda, Brennan, Paul, McKay, James, Delfau-Larue, Marie-Helene, Link, Brian K., Magnani, Corrado, Ennas, Maria Grazia, Latte, Giancarlo, Feldman, Andrew L., Doo, Nicole Wong, Giles, Graham G., Southey, Melissa C., Milne, Roger L., Offit, Kenneth, Musinsky, Jacob, Arslan, Alan A., Purdue, Mark P., Adami, Hans-Olov, Melbye, Mads, Glimelius, Bengt, Conde, Lucia, Camp, Nicola J., Glenn, Martha, Curtin, Karen, Clavel, Jacqueline, Monnereau, Alain, Cox, David G., Ghesquieres, Herve, Salles, Gilles, Bofetta, Paulo, Foretova, Lenka, Staines, Anthony, Davis, Scott, Severson, Richard K., Lan, Qing, Brooks-Wilson, Angela, Smith, Martyn T., Roman, Eve, Kricker, Anne, Zhang, Yawei, Kraft, Peter, Chanock, Stephen J., Rothman, Nathaniel, Hartge, Patricia, and Skibola, Christine F.
Abstract: A growing number of loci within the human leukocyte antigen (HLA) region have been implicated in non-Hodgkin lymphoma (NHL) etiology. Here, we test a complementary hypothesis of "heterozygote advantage" regarding the role of HLA and NHL, whereby HLA diversity is beneficial and homozygous HLA loci are associated with increased disease risk. HLA alleles at class I and II loci were imputed from genome-wide association studies (GWAS) using SNP2HLA for 3,617 diffuse large B-cell lymphomas (DLBCL), 2,686 follicular lymphomas (FL), 2,878 chronic lymphocytic leukemia/small lymphocytic lymphomas (CLL/SLL), 741 marginal zone lymphomas (MZL), and 8,753 controls of European descent. Both DLBCL and MZL risk were elevated with homozygosity at class I HLA-B and -C loci (OR DLBCL = 1.31, 95% CI = 1.06-1.60; OR MZL = 1.45, 95% CI = 1.12-1.89) and class II HLA-DRB1 locus (OR DLBCL = 2.10, 95% CI = 1.24-3.55; OR MZL = 2.10, 95% CI = 0.99-4.45). Increased FL risk was observed with the overall increase in number of homozygous HLA class II loci (P trend < 0.0001, FDR = 0.0005). These results support a role for HLA zygosity in NHL etiology and suggests that distinct immune pathways may underly the etiology of the different NHL subtypes. Significance: HLA gene diversity reduces risk for non-Hodgkin lymphoma.
Published: 2018
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39. Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer

Author: Klein, Alison P., Wolpin, Brian M., Risch, Harvey A., Stolzenberg-Solomon, Rachael Z., Mocci, Evelina, Zhang, Mingfeng, Canzian, Federico, Childs, Erica J., Hoskins, Jason W., Jermusyk, Ashley, Zhong, Jun, Chen, Fei, Albanes, Demetrius, Andreotti, Gabriella, Arslan, Alan A., Babic, Ana, Bamlet, William R., Beane-Freeman, Laura, Berndt, Sonja I., Blackford, Amanda, Borges, Michael, Borgida, Ayelet, Bracci, Paige M., Brais, Lauren, Brennan, Paul, Brenner, Hermann, Bueno-de-Mesquita, Bas, Buring, Julie, Campa, Daniele, Capurso, Gabriele, Cavestro, Giulia Martina, Chaffee, Kari G., Chung, Charles C., Cleary, Sean, Cotterchio, Michelle, Dijk, Frederike, Duell, Eric J., Foretova, Lenka, Fuchs, Charles, Funel, Niccola, Gallinger, Steven, Gaziano, J. Michael M., Gazouli, Maria, Giles, Graham G., Giovannucci, Edward, Goggins, Michael, Goodman, Gary E., Goodman, Phyllis J., Hackert, Thilo, Haiman, Christopher, Hartge, Patricia, Hasan, Manal, Hegyi, Peter, Helzlsouer, Kathy J., Herman, Joseph, Holcatova, Ivana, Holly, Elizabeth A., Hoover, Robert, Hung, Rayjean J., Jacobs, Eric J., Jamroziak, Krzysztof, Janout, Vladimir, Kaaks, Rudolf, Khaw, Kay-Tee, Klein, Eric A., Kogevinas, Manolis, Kooperberg, Charles, Kulke, Matthew H., Kupcinskas, Juozas, Kurtz, Robert J., Laheru, Daniel, Landi, Stefano, Lawlor, Rita T., Lee, I. -Min, LeMarchand, Loic, Lu, Lingeng, Malats, Nuria, Mambrini, Andrea, Mannisto, Satu, Milne, Roger L., Mohelnikova-Duchonova, Beatrice, Neale, Rachel E., Neoptolemos, John P., Oberg, Ann L., Olson, Sara H., Orlow, Irene, Pasquali, Claudio, Patel, Alpa V., Peters, Ulrike, Pezzilli, Raffaele, Porta, Miquel, Real, Francisco X., Rothman, Nathaniel, Scelo, Ghislaine, Sesso, Howard D., Severi, Gianluca, Shu, Xiao-Ou, Silverman, Debra, Smith, Jill P., Soucek, Pavel, Sund, Malin, Talar-Wojnarowska, Renata, Tavano, Francesca, Thornquist, Mark D., Tobias, Geoffrey S., Van Den Eeden, Stephen K., Vashist, Yogesh, Visvanathan, Kala, Vodicka, Pavel, Wactawski-Wende, Jean, Wang, Zhaoming, Wentzensen, Nicolas, White, Emily, Yu, Herbert, Yu, Kai, Zeleniuch-Jacquotte, Anne, Zheng, Wei, Kraft, Peter, Li, Donghui, Chanock, Stephen, Obazee, Ofure, Petersen, Gloria M., Amundadottir, Laufey T., Klein, Alison P., Wolpin, Brian M., Risch, Harvey A., Stolzenberg-Solomon, Rachael Z., Mocci, Evelina, Zhang, Mingfeng, Canzian, Federico, Childs, Erica J., Hoskins, Jason W., Jermusyk, Ashley, Zhong, Jun, Chen, Fei, Albanes, Demetrius, Andreotti, Gabriella, Arslan, Alan A., Babic, Ana, Bamlet, William R., Beane-Freeman, Laura, Berndt, Sonja I., Blackford, Amanda, Borges, Michael, Borgida, Ayelet, Bracci, Paige M., Brais, Lauren, Brennan, Paul, Brenner, Hermann, Bueno-de-Mesquita, Bas, Buring, Julie, Campa, Daniele, Capurso, Gabriele, Cavestro, Giulia Martina, Chaffee, Kari G., Chung, Charles C., Cleary, Sean, Cotterchio, Michelle, Dijk, Frederike, Duell, Eric J., Foretova, Lenka, Fuchs, Charles, Funel, Niccola, Gallinger, Steven, Gaziano, J. Michael M., Gazouli, Maria, Giles, Graham G., Giovannucci, Edward, Goggins, Michael, Goodman, Gary E., Goodman, Phyllis J., Hackert, Thilo, Haiman, Christopher, Hartge, Patricia, Hasan, Manal, Hegyi, Peter, Helzlsouer, Kathy J., Herman, Joseph, Holcatova, Ivana, Holly, Elizabeth A., Hoover, Robert, Hung, Rayjean J., Jacobs, Eric J., Jamroziak, Krzysztof, Janout, Vladimir, Kaaks, Rudolf, Khaw, Kay-Tee, Klein, Eric A., Kogevinas, Manolis, Kooperberg, Charles, Kulke, Matthew H., Kupcinskas, Juozas, Kurtz, Robert J., Laheru, Daniel, Landi, Stefano, Lawlor, Rita T., Lee, I. -Min, LeMarchand, Loic, Lu, Lingeng, Malats, Nuria, Mambrini, Andrea, Mannisto, Satu, Milne, Roger L., Mohelnikova-Duchonova, Beatrice, Neale, Rachel E., Neoptolemos, John P., Oberg, Ann L., Olson, Sara H., Orlow, Irene, Pasquali, Claudio, Patel, Alpa V., Peters, Ulrike, Pezzilli, Raffaele, Porta, Miquel, Real, Francisco X., Rothman, Nathaniel, Scelo, Ghislaine, Sesso, Howard D., Severi, Gianluca, Shu, Xiao-Ou, Silverman, Debra, Smith, Jill P., Soucek, Pavel, Sund, Malin, Talar-Wojnarowska, Renata, Tavano, Francesca, Thornquist, Mark D., Tobias, Geoffrey S., Van Den Eeden, Stephen K., Vashist, Yogesh, Visvanathan, Kala, Vodicka, Pavel, Wactawski-Wende, Jean, Wang, Zhaoming, Wentzensen, Nicolas, White, Emily, Yu, Herbert, Yu, Kai, Zeleniuch-Jacquotte, Anne, Zheng, Wei, Kraft, Peter, Li, Donghui, Chanock, Stephen, Obazee, Ofure, Petersen, Gloria M., and Amundadottir, Laufey T.
Abstract: In 2020, 146,063 deaths due to pancreatic cancer are estimated to occur in Europe and the United States combined. To identify common susceptibility alleles, we performed the largest pancreatic cancer GWAS to date, including 9040 patients and 12,496 controls of European ancestry from the Pancreatic Cancer Cohort Consortium (PanScan) and the Pancreatic Cancer Case-Control Consortium (PanC4). Here, we find significant evidence of a novel association at rs78417682 (7p12/TNS3, P = 4.35 x 10(-8)). Replication of 10 promising signals in up to 2737 patients and 4752 controls from the PANcreatic Disease ReseArch (PAN-DoRA) consortium yields new genome-wide significant loci: rs13303010 at 1p36.33 (NOC2L, P = 8.36 x 10(-14)), rs2941471 at 8q21.11 (HNF4G, P = 6.60 x 10(-10)), rs4795218 at 17q12 (HNF1B, P = 1.32 x 10(-8)), and rs1517037 at 18q21.32 (GRP, P = 3.28 x 10(-8)). rs78417682 is not statistically significantly associated with pancreatic cancer in PANDoRA. Expression quantitative trait locus analysis in three independent pancreatic data sets provides molecular support of NOC2L as a pancreatic cancer susceptibility gene.
Published: 2018
Full Text: View/download PDF

40. Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer

Author: Klein, Alison P., Wolpin, Brian M., Risch, Harvey A., Stolzenberg-Solomon, Rachael Z., Mocci, Evelina, Zhang, Mingfeng, Canzian, Federico, Childs, Erica J., Hoskins, Jason W., Jermusyk, Ashley, Zhong, Jun, Chen, Fei, Albanes, Demetrius, Andreotti, Gabriella, Arslan, Alan A., Babic, Ana, Bamlet, William R., Beane-Freeman, Laura, Berndt, Sonja I., Blackford, Amanda, Borges, Michael, Borgida, Ayelet, Bracci, Paige M., Brais, Lauren, Brennan, Paul, Brenner, Hermann, Bueno-de-Mesquita, Bas, Buring, Julie, Campa, Daniele, Capurso, Gabriele, Cavestro, Giulia Martina, Chaffee, Kari G., Chung, Charles C., Cleary, Sean, Cotterchio, Michelle, Dijk, Frederike, Duell, Eric J., Foretova, Lenka, Fuchs, Charles, Funel, Niccola, Gallinger, Steven, Gaziano, J. Michael M., Gazouli, Maria, Giles, Graham G., Giovannucci, Edward, Goggins, Michael, Goodman, Gary E., Goodman, Phyllis J., Hackert, Thilo, Haiman, Christopher, Hartge, Patricia, Hasan, Manal, Hegyi, Peter, Helzlsouer, Kathy J., Herman, Joseph, Holcatova, Ivana, Holly, Elizabeth A., Hoover, Robert, Hung, Rayjean J., Jacobs, Eric J., Jamroziak, Krzysztof, Janout, Vladimir, Kaaks, Rudolf, Khaw, Kay-Tee, Klein, Eric A., Kogevinas, Manolis, Kooperberg, Charles, Kulke, Matthew H., Kupcinskas, Juozas, Kurtz, Robert J., Laheru, Daniel, Landi, Stefano, Lawlor, Rita T., Lee, I. -Min, LeMarchand, Loic, Lu, Lingeng, Malats, Nuria, Mambrini, Andrea, Mannisto, Satu, Milne, Roger L., Mohelnikova-Duchonova, Beatrice, Neale, Rachel E., Neoptolemos, John P., Oberg, Ann L., Olson, Sara H., Orlow, Irene, Pasquali, Claudio, Patel, Alpa V., Peters, Ulrike, Pezzilli, Raffaele, Porta, Miquel, Real, Francisco X., Rothman, Nathaniel, Scelo, Ghislaine, Sesso, Howard D., Severi, Gianluca, Shu, Xiao-Ou, Silverman, Debra, Smith, Jill P., Soucek, Pavel, Sund, Malin, Talar-Wojnarowska, Renata, Tavano, Francesca, Thornquist, Mark D., Tobias, Geoffrey S., Van Den Eeden, Stephen K., Vashist, Yogesh, Visvanathan, Kala, Vodicka, Pavel, Wactawski-Wende, Jean, Wang, Zhaoming, Wentzensen, Nicolas, White, Emily, Yu, Herbert, Yu, Kai, Zeleniuch-Jacquotte, Anne, Zheng, Wei, Kraft, Peter, Li, Donghui, Chanock, Stephen, Obazee, Ofure, Petersen, Gloria M., Amundadottir, Laufey T., Klein, Alison P., Wolpin, Brian M., Risch, Harvey A., Stolzenberg-Solomon, Rachael Z., Mocci, Evelina, Zhang, Mingfeng, Canzian, Federico, Childs, Erica J., Hoskins, Jason W., Jermusyk, Ashley, Zhong, Jun, Chen, Fei, Albanes, Demetrius, Andreotti, Gabriella, Arslan, Alan A., Babic, Ana, Bamlet, William R., Beane-Freeman, Laura, Berndt, Sonja I., Blackford, Amanda, Borges, Michael, Borgida, Ayelet, Bracci, Paige M., Brais, Lauren, Brennan, Paul, Brenner, Hermann, Bueno-de-Mesquita, Bas, Buring, Julie, Campa, Daniele, Capurso, Gabriele, Cavestro, Giulia Martina, Chaffee, Kari G., Chung, Charles C., Cleary, Sean, Cotterchio, Michelle, Dijk, Frederike, Duell, Eric J., Foretova, Lenka, Fuchs, Charles, Funel, Niccola, Gallinger, Steven, Gaziano, J. Michael M., Gazouli, Maria, Giles, Graham G., Giovannucci, Edward, Goggins, Michael, Goodman, Gary E., Goodman, Phyllis J., Hackert, Thilo, Haiman, Christopher, Hartge, Patricia, Hasan, Manal, Hegyi, Peter, Helzlsouer, Kathy J., Herman, Joseph, Holcatova, Ivana, Holly, Elizabeth A., Hoover, Robert, Hung, Rayjean J., Jacobs, Eric J., Jamroziak, Krzysztof, Janout, Vladimir, Kaaks, Rudolf, Khaw, Kay-Tee, Klein, Eric A., Kogevinas, Manolis, Kooperberg, Charles, Kulke, Matthew H., Kupcinskas, Juozas, Kurtz, Robert J., Laheru, Daniel, Landi, Stefano, Lawlor, Rita T., Lee, I. -Min, LeMarchand, Loic, Lu, Lingeng, Malats, Nuria, Mambrini, Andrea, Mannisto, Satu, Milne, Roger L., Mohelnikova-Duchonova, Beatrice, Neale, Rachel E., Neoptolemos, John P., Oberg, Ann L., Olson, Sara H., Orlow, Irene, Pasquali, Claudio, Patel, Alpa V., Peters, Ulrike, Pezzilli, Raffaele, Porta, Miquel, Real, Francisco X., Rothman, Nathaniel, Scelo, Ghislaine, Sesso, Howard D., Severi, Gianluca, Shu, Xiao-Ou, Silverman, Debra, Smith, Jill P., Soucek, Pavel, Sund, Malin, Talar-Wojnarowska, Renata, Tavano, Francesca, Thornquist, Mark D., Tobias, Geoffrey S., Van Den Eeden, Stephen K., Vashist, Yogesh, Visvanathan, Kala, Vodicka, Pavel, Wactawski-Wende, Jean, Wang, Zhaoming, Wentzensen, Nicolas, White, Emily, Yu, Herbert, Yu, Kai, Zeleniuch-Jacquotte, Anne, Zheng, Wei, Kraft, Peter, Li, Donghui, Chanock, Stephen, Obazee, Ofure, Petersen, Gloria M., and Amundadottir, Laufey T.
Abstract: In 2020, 146,063 deaths due to pancreatic cancer are estimated to occur in Europe and the United States combined. To identify common susceptibility alleles, we performed the largest pancreatic cancer GWAS to date, including 9040 patients and 12,496 controls of European ancestry from the Pancreatic Cancer Cohort Consortium (PanScan) and the Pancreatic Cancer Case-Control Consortium (PanC4). Here, we find significant evidence of a novel association at rs78417682 (7p12/TNS3, P = 4.35 x 10(-8)). Replication of 10 promising signals in up to 2737 patients and 4752 controls from the PANcreatic Disease ReseArch (PAN-DoRA) consortium yields new genome-wide significant loci: rs13303010 at 1p36.33 (NOC2L, P = 8.36 x 10(-14)), rs2941471 at 8q21.11 (HNF4G, P = 6.60 x 10(-10)), rs4795218 at 17q12 (HNF1B, P = 1.32 x 10(-8)), and rs1517037 at 18q21.32 (GRP, P = 3.28 x 10(-8)). rs78417682 is not statistically significantly associated with pancreatic cancer in PANDoRA. Expression quantitative trait locus analysis in three independent pancreatic data sets provides molecular support of NOC2L as a pancreatic cancer susceptibility gene.
Published: 2018
Full Text: View/download PDF

41. Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer

Author: Klein, Alison P., Wolpin, Brian M., Risch, Harvey A., Stolzenberg-Solomon, Rachael Z., Mocci, Evelina, Zhang, Mingfeng, Canzian, Federico, Childs, Erica J., Hoskins, Jason W., Jermusyk, Ashley, Zhong, Jun, Chen, Fei, Albanes, Demetrius, Andreotti, Gabriella, Arslan, Alan A., Babic, Ana, Bamlet, William R., Beane-Freeman, Laura, Berndt, Sonja I., Blackford, Amanda, Borges, Michael, Borgida, Ayelet, Bracci, Paige M., Brais, Lauren, Brennan, Paul, Brenner, Hermann, Bueno-de-Mesquita, Bas, Buring, Julie, Campa, Daniele, Capurso, Gabriele, Cavestro, Giulia Martina, Chaffee, Kari G., Chung, Charles C., Cleary, Sean, Cotterchio, Michelle, Dijk, Frederike, Duell, Eric J., Foretova, Lenka, Fuchs, Charles, Funel, Niccola, Gallinger, Steven, Gaziano, J. Michael M., Gazouli, Maria, Giles, Graham G., Giovannucci, Edward, Goggins, Michael, Goodman, Gary E., Goodman, Phyllis J., Hackert, Thilo, Haiman, Christopher, Hartge, Patricia, Hasan, Manal, Hegyi, Peter, Helzlsouer, Kathy J., Herman, Joseph, Holcatova, Ivana, Holly, Elizabeth A., Hoover, Robert, Hung, Rayjean J., Jacobs, Eric J., Jamroziak, Krzysztof, Janout, Vladimir, Kaaks, Rudolf, Khaw, Kay-Tee, Klein, Eric A., Kogevinas, Manolis, Kooperberg, Charles, Kulke, Matthew H., Kupcinskas, Juozas, Kurtz, Robert J., Laheru, Daniel, Landi, Stefano, Lawlor, Rita T., Lee, I. -Min, LeMarchand, Loic, Lu, Lingeng, Malats, Nuria, Mambrini, Andrea, Mannisto, Satu, Milne, Roger L., Mohelnikova-Duchonova, Beatrice, Neale, Rachel E., Neoptolemos, John P., Oberg, Ann L., Olson, Sara H., Orlow, Irene, Pasquali, Claudio, Patel, Alpa V., Peters, Ulrike, Pezzilli, Raffaele, Porta, Miquel, Real, Francisco X., Rothman, Nathaniel, Scelo, Ghislaine, Sesso, Howard D., Severi, Gianluca, Shu, Xiao-Ou, Silverman, Debra, Smith, Jill P., Soucek, Pavel, Sund, Malin, Talar-Wojnarowska, Renata, Tavano, Francesca, Thornquist, Mark D., Tobias, Geoffrey S., Van Den Eeden, Stephen K., Vashist, Yogesh, Visvanathan, Kala, Vodicka, Pavel, Wactawski-Wende, Jean, Wang, Zhaoming, Wentzensen, Nicolas, White, Emily, Yu, Herbert, Yu, Kai, Zeleniuch-Jacquotte, Anne, Zheng, Wei, Kraft, Peter, Li, Donghui, Chanock, Stephen, Obazee, Ofure, Petersen, Gloria M., Amundadottir, Laufey T., Klein, Alison P., Wolpin, Brian M., Risch, Harvey A., Stolzenberg-Solomon, Rachael Z., Mocci, Evelina, Zhang, Mingfeng, Canzian, Federico, Childs, Erica J., Hoskins, Jason W., Jermusyk, Ashley, Zhong, Jun, Chen, Fei, Albanes, Demetrius, Andreotti, Gabriella, Arslan, Alan A., Babic, Ana, Bamlet, William R., Beane-Freeman, Laura, Berndt, Sonja I., Blackford, Amanda, Borges, Michael, Borgida, Ayelet, Bracci, Paige M., Brais, Lauren, Brennan, Paul, Brenner, Hermann, Bueno-de-Mesquita, Bas, Buring, Julie, Campa, Daniele, Capurso, Gabriele, Cavestro, Giulia Martina, Chaffee, Kari G., Chung, Charles C., Cleary, Sean, Cotterchio, Michelle, Dijk, Frederike, Duell, Eric J., Foretova, Lenka, Fuchs, Charles, Funel, Niccola, Gallinger, Steven, Gaziano, J. Michael M., Gazouli, Maria, Giles, Graham G., Giovannucci, Edward, Goggins, Michael, Goodman, Gary E., Goodman, Phyllis J., Hackert, Thilo, Haiman, Christopher, Hartge, Patricia, Hasan, Manal, Hegyi, Peter, Helzlsouer, Kathy J., Herman, Joseph, Holcatova, Ivana, Holly, Elizabeth A., Hoover, Robert, Hung, Rayjean J., Jacobs, Eric J., Jamroziak, Krzysztof, Janout, Vladimir, Kaaks, Rudolf, Khaw, Kay-Tee, Klein, Eric A., Kogevinas, Manolis, Kooperberg, Charles, Kulke, Matthew H., Kupcinskas, Juozas, Kurtz, Robert J., Laheru, Daniel, Landi, Stefano, Lawlor, Rita T., Lee, I. -Min, LeMarchand, Loic, Lu, Lingeng, Malats, Nuria, Mambrini, Andrea, Mannisto, Satu, Milne, Roger L., Mohelnikova-Duchonova, Beatrice, Neale, Rachel E., Neoptolemos, John P., Oberg, Ann L., Olson, Sara H., Orlow, Irene, Pasquali, Claudio, Patel, Alpa V., Peters, Ulrike, Pezzilli, Raffaele, Porta, Miquel, Real, Francisco X., Rothman, Nathaniel, Scelo, Ghislaine, Sesso, Howard D., Severi, Gianluca, Shu, Xiao-Ou, Silverman, Debra, Smith, Jill P., Soucek, Pavel, Sund, Malin, Talar-Wojnarowska, Renata, Tavano, Francesca, Thornquist, Mark D., Tobias, Geoffrey S., Van Den Eeden, Stephen K., Vashist, Yogesh, Visvanathan, Kala, Vodicka, Pavel, Wactawski-Wende, Jean, Wang, Zhaoming, Wentzensen, Nicolas, White, Emily, Yu, Herbert, Yu, Kai, Zeleniuch-Jacquotte, Anne, Zheng, Wei, Kraft, Peter, Li, Donghui, Chanock, Stephen, Obazee, Ofure, Petersen, Gloria M., and Amundadottir, Laufey T.
Abstract: In 2020, 146,063 deaths due to pancreatic cancer are estimated to occur in Europe and the United States combined. To identify common susceptibility alleles, we performed the largest pancreatic cancer GWAS to date, including 9040 patients and 12,496 controls of European ancestry from the Pancreatic Cancer Cohort Consortium (PanScan) and the Pancreatic Cancer Case-Control Consortium (PanC4). Here, we find significant evidence of a novel association at rs78417682 (7p12/TNS3, P = 4.35 x 10(-8)). Replication of 10 promising signals in up to 2737 patients and 4752 controls from the PANcreatic Disease ReseArch (PAN-DoRA) consortium yields new genome-wide significant loci: rs13303010 at 1p36.33 (NOC2L, P = 8.36 x 10(-14)), rs2941471 at 8q21.11 (HNF4G, P = 6.60 x 10(-10)), rs4795218 at 17q12 (HNF1B, P = 1.32 x 10(-8)), and rs1517037 at 18q21.32 (GRP, P = 3.28 x 10(-8)). rs78417682 is not statistically significantly associated with pancreatic cancer in PANDoRA. Expression quantitative trait locus analysis in three independent pancreatic data sets provides molecular support of NOC2L as a pancreatic cancer susceptibility gene.
Published: 2018
Full Text: View/download PDF

42. Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer

Author: Klein, Alison P., Wolpin, Brian M., Risch, Harvey A., Stolzenberg-Solomon, Rachael Z., Mocci, Evelina, Zhang, Mingfeng, Canzian, Federico, Childs, Erica J., Hoskins, Jason W., Jermusyk, Ashley, Zhong, Jun, Chen, Fei, Albanes, Demetrius, Andreotti, Gabriella, Arslan, Alan A., Babic, Ana, Bamlet, William R., Beane-Freeman, Laura, Berndt, Sonja I., Blackford, Amanda, Borges, Michael, Borgida, Ayelet, Bracci, Paige M., Brais, Lauren, Brennan, Paul, Brenner, Hermann, Bueno-De-Mesquita, Bas, Buring, Julie, Campa, Daniele, Capurso, Gabriele, Cavestro, Giulia Martina, Chaffee, Kari G., Chung, Charles C., Cleary, Sean, Cotterchio, Michelle, Dijk, Frederike, Duell, Eric J., Foretova, Lenka, Fuchs, Charles, Funel, Niccola, Gallinger, Steven, Gaziano, J. Michael M., Gazouli, Maria, Giles, Graham G., Giovannucci, Edward, Goggins, Michael, Goodman, Gary E., Goodman, Phyllis J., Hackert, Thilo, Haiman, Christopher, Hartge, Patricia, Hasan, Manal, Hegyi, Peter, Helzlsouer, Kathy J., Herman, Joseph, Holcatova, Ivana, Holly, Elizabeth A., Hoover, Robert, Hung, Rayjean J., Jacobs, Eric J., Jamroziak, Krzysztof, Janout, Vladimir, Kaaks, Rudolf, Khaw, Kay Tee, Klein, Eric A., Kogevinas, Manolis, Kooperberg, Charles, Kulke, Matthew H., Kupcinskas, Juozas, Kurtz, Robert J., Laheru, Daniel, Landi, Stefano, Lawlor, Rita T., Lee, I. Min, Lemarchand, Loic, Lu, Lingeng, Malats, Núria, Mambrini, Andrea, Mannisto, Satu, Milne, Roger L., Mohelníková-Duchoňová, Beatrice, Neale, Rachel E., Neoptolemos, John P., Oberg, Ann L., Olson, Sara H., Orlow, Irene, Pasquali, Claudio, Patel, Alpa V., Peters, Ulrike, Pezzilli, Raffaele, Porta, Miquel, Real, Francisco X., Rothman, Nathaniel, Scelo, Ghislaine, Sesso, Howard D., Severi, Gianluca, Shu, Xiao Ou, Silverman, Debra, Smith, Jill P., Soucek, Pavel, Sund, Malin, Talar-Wojnarowska, Renata, Tavano, Francesca, Thornquist, Mark D., Tobias, Geoffrey S., Van Den Eeden, Stephen K., Vashist, Yogesh, Visvanathan, Kala, Vodicka, Pavel, Wactawski-Wende, Jean, Wang, Zhaoming, Wentzensen, Nicolas, White, Emily, Yu, Herbert, Yu, Kai, Zeleniuch-Jacquotte, Anne, Zheng, Wei, Kraft, Peter, Li, Donghui, Chanock, Stephen, Obazee, Ofure, Petersen, Gloria M., Amundadottir, Laufey T., Klein, Alison P., Wolpin, Brian M., Risch, Harvey A., Stolzenberg-Solomon, Rachael Z., Mocci, Evelina, Zhang, Mingfeng, Canzian, Federico, Childs, Erica J., Hoskins, Jason W., Jermusyk, Ashley, Zhong, Jun, Chen, Fei, Albanes, Demetrius, Andreotti, Gabriella, Arslan, Alan A., Babic, Ana, Bamlet, William R., Beane-Freeman, Laura, Berndt, Sonja I., Blackford, Amanda, Borges, Michael, Borgida, Ayelet, Bracci, Paige M., Brais, Lauren, Brennan, Paul, Brenner, Hermann, Bueno-De-Mesquita, Bas, Buring, Julie, Campa, Daniele, Capurso, Gabriele, Cavestro, Giulia Martina, Chaffee, Kari G., Chung, Charles C., Cleary, Sean, Cotterchio, Michelle, Dijk, Frederike, Duell, Eric J., Foretova, Lenka, Fuchs, Charles, Funel, Niccola, Gallinger, Steven, Gaziano, J. Michael M., Gazouli, Maria, Giles, Graham G., Giovannucci, Edward, Goggins, Michael, Goodman, Gary E., Goodman, Phyllis J., Hackert, Thilo, Haiman, Christopher, Hartge, Patricia, Hasan, Manal, Hegyi, Peter, Helzlsouer, Kathy J., Herman, Joseph, Holcatova, Ivana, Holly, Elizabeth A., Hoover, Robert, Hung, Rayjean J., Jacobs, Eric J., Jamroziak, Krzysztof, Janout, Vladimir, Kaaks, Rudolf, Khaw, Kay Tee, Klein, Eric A., Kogevinas, Manolis, Kooperberg, Charles, Kulke, Matthew H., Kupcinskas, Juozas, Kurtz, Robert J., Laheru, Daniel, Landi, Stefano, Lawlor, Rita T., Lee, I. Min, Lemarchand, Loic, Lu, Lingeng, Malats, Núria, Mambrini, Andrea, Mannisto, Satu, Milne, Roger L., Mohelníková-Duchoňová, Beatrice, Neale, Rachel E., Neoptolemos, John P., Oberg, Ann L., Olson, Sara H., Orlow, Irene, Pasquali, Claudio, Patel, Alpa V., Peters, Ulrike, Pezzilli, Raffaele, Porta, Miquel, Real, Francisco X., Rothman, Nathaniel, Scelo, Ghislaine, Sesso, Howard D., Severi, Gianluca, Shu, Xiao Ou, Silverman, Debra, Smith, Jill P., Soucek, Pavel, Sund, Malin, Talar-Wojnarowska, Renata, Tavano, Francesca, Thornquist, Mark D., Tobias, Geoffrey S., Van Den Eeden, Stephen K., Vashist, Yogesh, Visvanathan, Kala, Vodicka, Pavel, Wactawski-Wende, Jean, Wang, Zhaoming, Wentzensen, Nicolas, White, Emily, Yu, Herbert, Yu, Kai, Zeleniuch-Jacquotte, Anne, Zheng, Wei, Kraft, Peter, Li, Donghui, Chanock, Stephen, Obazee, Ofure, Petersen, Gloria M., and Amundadottir, Laufey T.
Published: 2018

43. Analgesic Use and Ovarian Cancer Risk: An Analysis in the Ovarian Cancer Cohort Consortium

Author: Trabert, Britton, Trabert, Britton, Poole, Elizabeth M., White, Emily, Visvanathan, Kala, Adami, Hans-Olov, Anderson, Garnet L., Brasky, Theodore M., Brinton, Louise A., Fortner, Renee T., Gaudet, Mia, Hartge, Patricia, Hoffman-Bolton, Judith, Jones, Michael, Lacey, James V., Larsson, Susanna C., Mackenzie, Gerardo G., Schouten, Leo J., Sandler, Dale P., O'Brien, Katie, Patel, Alpa V., Peters, Ulrike, Prizment, Anna, Robien, Kim, Setiawan, Wendy V., Swerdlow, Anthony, van den Brandt, Piet A., Weiderpass, Elisabete, Wilkens, Lynne R., Wolk, Alicja, Wentzensen, Nicolas, Tworoger, Shelley S., Ovarian Canc Cohort Consortium, Trabert, Britton, Trabert, Britton, Poole, Elizabeth M., White, Emily, Visvanathan, Kala, Adami, Hans-Olov, Anderson, Garnet L., Brasky, Theodore M., Brinton, Louise A., Fortner, Renee T., Gaudet, Mia, Hartge, Patricia, Hoffman-Bolton, Judith, Jones, Michael, Lacey, James V., Larsson, Susanna C., Mackenzie, Gerardo G., Schouten, Leo J., Sandler, Dale P., O'Brien, Katie, Patel, Alpa V., Peters, Ulrike, Prizment, Anna, Robien, Kim, Setiawan, Wendy V., Swerdlow, Anthony, van den Brandt, Piet A., Weiderpass, Elisabete, Wilkens, Lynne R., Wolk, Alicja, Wentzensen, Nicolas, Tworoger, Shelley S., and Ovarian Canc Cohort Consortium
Published: 2018

44. Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer

Author: Klein, Alison P., Wolpin, Brian M., Risch, Harvey A., Stolzenberg-Solomon, Rachael Z., Mocci, Evelina, Zhang, Mingfeng, Canzian, Federico, Childs, Erica J., Hoskins, Jason W., Jermusyk, Ashley, Zhong, Jun, Chen, Fei, Albanes, Demetrius, Andreotti, Gabriella, Arslan, Alan A., Babic, Ana, Bamlet, William R., Beane-Freeman, Laura, Berndt, Sonja I., Blackford, Amanda, Borges, Michael, Borgida, Ayelet, Bracci, Paige M., Brais, Lauren, Brennan, Paul, Brenner, Hermann, Bueno-De-Mesquita, Bas, Buring, Julie, Campa, Daniele, Capurso, Gabriele, Cavestro, Giulia Martina, Chaffee, Kari G., Chung, Charles C., Cleary, Sean, Cotterchio, Michelle, Dijk, Frederike, Duell, Eric J., Foretova, Lenka, Fuchs, Charles, Funel, Niccola, Gallinger, Steven, Gaziano, J. Michael M., Gazouli, Maria, Giles, Graham G., Giovannucci, Edward, Goggins, Michael, Goodman, Gary E., Goodman, Phyllis J., Hackert, Thilo, Haiman, Christopher, Hartge, Patricia, Hasan, Manal, Hegyi, Peter, Helzlsouer, Kathy J., Herman, Joseph, Holcatova, Ivana, Holly, Elizabeth A., Hoover, Robert, Hung, Rayjean J., Jacobs, Eric J., Jamroziak, Krzysztof, Janout, Vladimir, Kaaks, Rudolf, Khaw, Kay Tee, Klein, Eric A., Kogevinas, Manolis, Kooperberg, Charles, Kulke, Matthew H., Kupcinskas, Juozas, Kurtz, Robert J., Laheru, Daniel, Landi, Stefano, Lawlor, Rita T., Lee, I. Min, Lemarchand, Loic, Lu, Lingeng, Malats, Núria, Mambrini, Andrea, Mannisto, Satu, Milne, Roger L., Mohelníková-Duchoňová, Beatrice, Neale, Rachel E., Neoptolemos, John P., Oberg, Ann L., Olson, Sara H., Orlow, Irene, Pasquali, Claudio, Patel, Alpa V., Peters, Ulrike, Pezzilli, Raffaele, Porta, Miquel, Real, Francisco X., Rothman, Nathaniel, Scelo, Ghislaine, Sesso, Howard D., Severi, Gianluca, Shu, Xiao Ou, Silverman, Debra, Smith, Jill P., Soucek, Pavel, Sund, Malin, Talar-Wojnarowska, Renata, Tavano, Francesca, Thornquist, Mark D., Tobias, Geoffrey S., Van Den Eeden, Stephen K., Vashist, Yogesh, Visvanathan, Kala, Vodicka, Pavel, Wactawski-Wende, Jean, Wang, Zhaoming, Wentzensen, Nicolas, White, Emily, Yu, Herbert, Yu, Kai, Zeleniuch-Jacquotte, Anne, Zheng, Wei, Kraft, Peter, Li, Donghui, Chanock, Stephen, Obazee, Ofure, Petersen, Gloria M., Amundadottir, Laufey T., Klein, Alison P., Wolpin, Brian M., Risch, Harvey A., Stolzenberg-Solomon, Rachael Z., Mocci, Evelina, Zhang, Mingfeng, Canzian, Federico, Childs, Erica J., Hoskins, Jason W., Jermusyk, Ashley, Zhong, Jun, Chen, Fei, Albanes, Demetrius, Andreotti, Gabriella, Arslan, Alan A., Babic, Ana, Bamlet, William R., Beane-Freeman, Laura, Berndt, Sonja I., Blackford, Amanda, Borges, Michael, Borgida, Ayelet, Bracci, Paige M., Brais, Lauren, Brennan, Paul, Brenner, Hermann, Bueno-De-Mesquita, Bas, Buring, Julie, Campa, Daniele, Capurso, Gabriele, Cavestro, Giulia Martina, Chaffee, Kari G., Chung, Charles C., Cleary, Sean, Cotterchio, Michelle, Dijk, Frederike, Duell, Eric J., Foretova, Lenka, Fuchs, Charles, Funel, Niccola, Gallinger, Steven, Gaziano, J. Michael M., Gazouli, Maria, Giles, Graham G., Giovannucci, Edward, Goggins, Michael, Goodman, Gary E., Goodman, Phyllis J., Hackert, Thilo, Haiman, Christopher, Hartge, Patricia, Hasan, Manal, Hegyi, Peter, Helzlsouer, Kathy J., Herman, Joseph, Holcatova, Ivana, Holly, Elizabeth A., Hoover, Robert, Hung, Rayjean J., Jacobs, Eric J., Jamroziak, Krzysztof, Janout, Vladimir, Kaaks, Rudolf, Khaw, Kay Tee, Klein, Eric A., Kogevinas, Manolis, Kooperberg, Charles, Kulke, Matthew H., Kupcinskas, Juozas, Kurtz, Robert J., Laheru, Daniel, Landi, Stefano, Lawlor, Rita T., Lee, I. Min, Lemarchand, Loic, Lu, Lingeng, Malats, Núria, Mambrini, Andrea, Mannisto, Satu, Milne, Roger L., Mohelníková-Duchoňová, Beatrice, Neale, Rachel E., Neoptolemos, John P., Oberg, Ann L., Olson, Sara H., Orlow, Irene, Pasquali, Claudio, Patel, Alpa V., Peters, Ulrike, Pezzilli, Raffaele, Porta, Miquel, Real, Francisco X., Rothman, Nathaniel, Scelo, Ghislaine, Sesso, Howard D., Severi, Gianluca, Shu, Xiao Ou, Silverman, Debra, Smith, Jill P., Soucek, Pavel, Sund, Malin, Talar-Wojnarowska, Renata, Tavano, Francesca, Thornquist, Mark D., Tobias, Geoffrey S., Van Den Eeden, Stephen K., Vashist, Yogesh, Visvanathan, Kala, Vodicka, Pavel, Wactawski-Wende, Jean, Wang, Zhaoming, Wentzensen, Nicolas, White, Emily, Yu, Herbert, Yu, Kai, Zeleniuch-Jacquotte, Anne, Zheng, Wei, Kraft, Peter, Li, Donghui, Chanock, Stephen, Obazee, Ofure, Petersen, Gloria M., and Amundadottir, Laufey T.
Published: 2018

45. Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer

Author: MS MDL 1, Klein, Alison P., Wolpin, Brian M., Risch, Harvey A., Stolzenberg-Solomon, Rachael Z., Mocci, Evelina, Zhang, Mingfeng, Canzian, Federico, Childs, Erica J., Hoskins, Jason W., Jermusyk, Ashley, Zhong, Jun, Chen, Fei, Albanes, Demetrius, Andreotti, Gabriella, Arslan, Alan A., Babic, Ana, Bamlet, William R., Beane-Freeman, Laura, Berndt, Sonja I., Blackford, Amanda, Borges, Michael, Borgida, Ayelet, Bracci, Paige M., Brais, Lauren, Brennan, Paul, Brenner, Hermann, Bueno-De-Mesquita, Bas, Buring, Julie, Campa, Daniele, Capurso, Gabriele, Cavestro, Giulia Martina, Chaffee, Kari G., Chung, Charles C., Cleary, Sean, Cotterchio, Michelle, Dijk, Frederike, Duell, Eric J., Foretova, Lenka, Fuchs, Charles, Funel, Niccola, Gallinger, Steven, Gaziano, J. Michael M., Gazouli, Maria, Giles, Graham G., Giovannucci, Edward, Goggins, Michael, Goodman, Gary E., Goodman, Phyllis J., Hackert, Thilo, Haiman, Christopher, Hartge, Patricia, Hasan, Manal, Hegyi, Peter, Helzlsouer, Kathy J., Herman, Joseph, Holcatova, Ivana, Holly, Elizabeth A., Hoover, Robert, Hung, Rayjean J., Jacobs, Eric J., Jamroziak, Krzysztof, Janout, Vladimir, Kaaks, Rudolf, Khaw, Kay Tee, Klein, Eric A., Kogevinas, Manolis, Kooperberg, Charles, Kulke, Matthew H., Kupcinskas, Juozas, Kurtz, Robert J., Laheru, Daniel, Landi, Stefano, Lawlor, Rita T., Lee, I. Min, Lemarchand, Loic, Lu, Lingeng, Malats, Núria, Mambrini, Andrea, Mannisto, Satu, Milne, Roger L., Mohelníková-Duchoňová, Beatrice, Neale, Rachel E., Neoptolemos, John P., Oberg, Ann L., Olson, Sara H., Orlow, Irene, Pasquali, Claudio, Patel, Alpa V., Peters, Ulrike, Pezzilli, Raffaele, Porta, Miquel, Real, Francisco X., Rothman, Nathaniel, Scelo, Ghislaine, Sesso, Howard D., Severi, Gianluca, Shu, Xiao Ou, Silverman, Debra, Smith, Jill P., Soucek, Pavel, Sund, Malin, Talar-Wojnarowska, Renata, Tavano, Francesca, Thornquist, Mark D., Tobias, Geoffrey S., Van Den Eeden, Stephen K., Vashist, Yogesh, Visvanathan, Kala, Vodicka, Pavel, Wactawski-Wende, Jean, Wang, Zhaoming, Wentzensen, Nicolas, White, Emily, Yu, Herbert, Yu, Kai, Zeleniuch-Jacquotte, Anne, Zheng, Wei, Kraft, Peter, Li, Donghui, Chanock, Stephen, Obazee, Ofure, Petersen, Gloria M., Amundadottir, Laufey T., MS MDL 1, Klein, Alison P., Wolpin, Brian M., Risch, Harvey A., Stolzenberg-Solomon, Rachael Z., Mocci, Evelina, Zhang, Mingfeng, Canzian, Federico, Childs, Erica J., Hoskins, Jason W., Jermusyk, Ashley, Zhong, Jun, Chen, Fei, Albanes, Demetrius, Andreotti, Gabriella, Arslan, Alan A., Babic, Ana, Bamlet, William R., Beane-Freeman, Laura, Berndt, Sonja I., Blackford, Amanda, Borges, Michael, Borgida, Ayelet, Bracci, Paige M., Brais, Lauren, Brennan, Paul, Brenner, Hermann, Bueno-De-Mesquita, Bas, Buring, Julie, Campa, Daniele, Capurso, Gabriele, Cavestro, Giulia Martina, Chaffee, Kari G., Chung, Charles C., Cleary, Sean, Cotterchio, Michelle, Dijk, Frederike, Duell, Eric J., Foretova, Lenka, Fuchs, Charles, Funel, Niccola, Gallinger, Steven, Gaziano, J. Michael M., Gazouli, Maria, Giles, Graham G., Giovannucci, Edward, Goggins, Michael, Goodman, Gary E., Goodman, Phyllis J., Hackert, Thilo, Haiman, Christopher, Hartge, Patricia, Hasan, Manal, Hegyi, Peter, Helzlsouer, Kathy J., Herman, Joseph, Holcatova, Ivana, Holly, Elizabeth A., Hoover, Robert, Hung, Rayjean J., Jacobs, Eric J., Jamroziak, Krzysztof, Janout, Vladimir, Kaaks, Rudolf, Khaw, Kay Tee, Klein, Eric A., Kogevinas, Manolis, Kooperberg, Charles, Kulke, Matthew H., Kupcinskas, Juozas, Kurtz, Robert J., Laheru, Daniel, Landi, Stefano, Lawlor, Rita T., Lee, I. Min, Lemarchand, Loic, Lu, Lingeng, Malats, Núria, Mambrini, Andrea, Mannisto, Satu, Milne, Roger L., Mohelníková-Duchoňová, Beatrice, Neale, Rachel E., Neoptolemos, John P., Oberg, Ann L., Olson, Sara H., Orlow, Irene, Pasquali, Claudio, Patel, Alpa V., Peters, Ulrike, Pezzilli, Raffaele, Porta, Miquel, Real, Francisco X., Rothman, Nathaniel, Scelo, Ghislaine, Sesso, Howard D., Severi, Gianluca, Shu, Xiao Ou, Silverman, Debra, Smith, Jill P., Soucek, Pavel, Sund, Malin, Talar-Wojnarowska, Renata, Tavano, Francesca, Thornquist, Mark D., Tobias, Geoffrey S., Van Den Eeden, Stephen K., Vashist, Yogesh, Visvanathan, Kala, Vodicka, Pavel, Wactawski-Wende, Jean, Wang, Zhaoming, Wentzensen, Nicolas, White, Emily, Yu, Herbert, Yu, Kai, Zeleniuch-Jacquotte, Anne, Zheng, Wei, Kraft, Peter, Li, Donghui, Chanock, Stephen, Obazee, Ofure, Petersen, Gloria M., and Amundadottir, Laufey T.
Published: 2018

46. Analgesic Use and Ovarian Cancer Risk: An Analysis in the Ovarian Cancer Cohort Consortium

Author: Trabert, Britton, Poole, Elizabeth M., White, Emily, Visvanathan, Kala, Adami, Hans-Olov, Anderson, Garnet L., Brasky, Theodore M., Brinton, Louise A., Fortner, Renee T., Gaudet, Mia, Hartge, Patricia, Hoffman-Bolton, Judith, Jones, Michael, Lacey, James V., Larsson, Susanna C., Mackenzie, Gerardo G., Schouten, Leo J., Sandler, Dale P., O'Brien, Katie, Patel, Alpa V., Peters, Ulrike, Prizment, Anna, Robien, Kim, Setiawan, Wendy V., Swerdlow, Anthony, van den Brandt, Piet A., Weiderpass, Elisabete, Wilkens, Lynne R., Wolk, Alicja, Wentzensen, Nicolas, Tworoger, Shelley S., Ovarian Cancer Cohort Consortium (OC3), Trabert, Britton, Poole, Elizabeth M., White, Emily, Visvanathan, Kala, Adami, Hans-Olov, Anderson, Garnet L., Brasky, Theodore M., Brinton, Louise A., Fortner, Renee T., Gaudet, Mia, Hartge, Patricia, Hoffman-Bolton, Judith, Jones, Michael, Lacey, James V., Larsson, Susanna C., Mackenzie, Gerardo G., Schouten, Leo J., Sandler, Dale P., O'Brien, Katie, Patel, Alpa V., Peters, Ulrike, Prizment, Anna, Robien, Kim, Setiawan, Wendy V., Swerdlow, Anthony, van den Brandt, Piet A., Weiderpass, Elisabete, Wilkens, Lynne R., Wolk, Alicja, Wentzensen, Nicolas, Tworoger, Shelley S., and Ovarian Cancer Cohort Consortium (OC3)
Published: 2018

47. Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer

Author: Klein, Alison P., Wolpin, Brian M., Risch, Harvey A., Stolzenberg-Solomon, Rachael Z., Mocci, Evelina, Zhang, Mingfeng, Canzian, Federico, Childs, Erica J., Hoskins, Jason W., Jermusyk, Ashley, Zhong, Jun, Chen, Fei, Albanes, Demetrius, Andreotti, Gabriella, Arslan, Alan A., Babic, Ana, Bamlet, William R., Beane-Freeman, Laura, Berndt, Sonja I., Blackford, Amanda, Borges, Michael, Borgida, Ayelet, Bracci, Paige M., Brais, Lauren, Brennan, Paul, Brenner, Hermann, Bueno-de-Mesquita, Bas, Buring, Julie, Campa, Daniele, Capurso, Gabriele, Cavestro, Giulia Martina, Chaffee, Kari G., Chung, Charles C., Cleary, Sean, Cotterchio, Michelle, Dijk, Frederike, Duell, Eric J., Foretova, Lenka, Fuchs, Charles, Funel, Niccola, Gallinger, Steven, Gaziano, J. Michael M., Gazouli, Maria, Giles, Graham G., Giovannucci, Edward, Goggins, Michael, Goodman, Gary E., Goodman, Phyllis J., Hackert, Thilo, Haiman, Christopher, Hartge, Patricia, Hasan, Manal, Hegyi, Peter, Helzlsouer, Kathy J., Herman, Joseph, Holcatova, Ivana, Holly, Elizabeth A., Hoover, Robert, Hung, Rayjean J., Jacobs, Eric J., Jamroziak, Krzysztof, Janout, Vladimir, Kaaks, Rudolf, Khaw, Kay-Tee, Klein, Eric A., Kogevinas, Manolis, Kooperberg, Charles, Kulke, Matthew H., Kupcinskas, Juozas, Kurtz, Robert J., Laheru, Daniel, Landi, Stefano, Lawlor, Rita T., Lee, I. -Min, LeMarchand, Loic, Lu, Lingeng, Malats, Nuria, Mambrini, Andrea, Mannisto, Satu, Milne, Roger L., Mohelnikova-Duchonova, Beatrice, Neale, Rachel E., Neoptolemos, John P., Oberg, Ann L., Olson, Sara H., Orlow, Irene, Pasquali, Claudio, Patel, Alpa V., Peters, Ulrike, Pezzilli, Raffaele, Porta, Miquel, Real, Francisco X., Rothman, Nathaniel, Scelo, Ghislaine, Sesso, Howard D., Severi, Gianluca, Shu, Xiao-Ou, Silverman, Debra, Smith, Jill P., Soucek, Pavel, Sund, Malin, Talar-Wojnarowska, Renata, Tavano, Francesca, Thornquist, Mark D., Tobias, Geoffrey S., Van Den Eeden, Stephen K., Vashist, Yogesh, Visvanathan, Kala, Vodicka, Pavel, Wactawski-Wende, Jean, Wang, Zhaoming, Wentzensen, Nicolas, White, Emily, Yu, Herbert, Yu, Kai, Zeleniuch-Jacquotte, Anne, Zheng, Wei, Kraft, Peter, Li, Donghui, Chanock, Stephen, Obazee, Ofure, Petersen, Gloria M., Amundadottir, Laufey T., Klein, Alison P., Wolpin, Brian M., Risch, Harvey A., Stolzenberg-Solomon, Rachael Z., Mocci, Evelina, Zhang, Mingfeng, Canzian, Federico, Childs, Erica J., Hoskins, Jason W., Jermusyk, Ashley, Zhong, Jun, Chen, Fei, Albanes, Demetrius, Andreotti, Gabriella, Arslan, Alan A., Babic, Ana, Bamlet, William R., Beane-Freeman, Laura, Berndt, Sonja I., Blackford, Amanda, Borges, Michael, Borgida, Ayelet, Bracci, Paige M., Brais, Lauren, Brennan, Paul, Brenner, Hermann, Bueno-de-Mesquita, Bas, Buring, Julie, Campa, Daniele, Capurso, Gabriele, Cavestro, Giulia Martina, Chaffee, Kari G., Chung, Charles C., Cleary, Sean, Cotterchio, Michelle, Dijk, Frederike, Duell, Eric J., Foretova, Lenka, Fuchs, Charles, Funel, Niccola, Gallinger, Steven, Gaziano, J. Michael M., Gazouli, Maria, Giles, Graham G., Giovannucci, Edward, Goggins, Michael, Goodman, Gary E., Goodman, Phyllis J., Hackert, Thilo, Haiman, Christopher, Hartge, Patricia, Hasan, Manal, Hegyi, Peter, Helzlsouer, Kathy J., Herman, Joseph, Holcatova, Ivana, Holly, Elizabeth A., Hoover, Robert, Hung, Rayjean J., Jacobs, Eric J., Jamroziak, Krzysztof, Janout, Vladimir, Kaaks, Rudolf, Khaw, Kay-Tee, Klein, Eric A., Kogevinas, Manolis, Kooperberg, Charles, Kulke, Matthew H., Kupcinskas, Juozas, Kurtz, Robert J., Laheru, Daniel, Landi, Stefano, Lawlor, Rita T., Lee, I. -Min, LeMarchand, Loic, Lu, Lingeng, Malats, Nuria, Mambrini, Andrea, Mannisto, Satu, Milne, Roger L., Mohelnikova-Duchonova, Beatrice, Neale, Rachel E., Neoptolemos, John P., Oberg, Ann L., Olson, Sara H., Orlow, Irene, Pasquali, Claudio, Patel, Alpa V., Peters, Ulrike, Pezzilli, Raffaele, Porta, Miquel, Real, Francisco X., Rothman, Nathaniel, Scelo, Ghislaine, Sesso, Howard D., Severi, Gianluca, Shu, Xiao-Ou, Silverman, Debra, Smith, Jill P., Soucek, Pavel, Sund, Malin, Talar-Wojnarowska, Renata, Tavano, Francesca, Thornquist, Mark D., Tobias, Geoffrey S., Van Den Eeden, Stephen K., Vashist, Yogesh, Visvanathan, Kala, Vodicka, Pavel, Wactawski-Wende, Jean, Wang, Zhaoming, Wentzensen, Nicolas, White, Emily, Yu, Herbert, Yu, Kai, Zeleniuch-Jacquotte, Anne, Zheng, Wei, Kraft, Peter, Li, Donghui, Chanock, Stephen, Obazee, Ofure, Petersen, Gloria M., and Amundadottir, Laufey T.
Abstract: In 2020, 146,063 deaths due to pancreatic cancer are estimated to occur in Europe and the United States combined. To identify common susceptibility alleles, we performed the largest pancreatic cancer GWAS to date, including 9040 patients and 12,496 controls of European ancestry from the Pancreatic Cancer Cohort Consortium (PanScan) and the Pancreatic Cancer Case-Control Consortium (PanC4). Here, we find significant evidence of a novel association at rs78417682 (7p12/TNS3, P = 4.35 x 10(-8)). Replication of 10 promising signals in up to 2737 patients and 4752 controls from the PANcreatic Disease ReseArch (PAN-DoRA) consortium yields new genome-wide significant loci: rs13303010 at 1p36.33 (NOC2L, P = 8.36 x 10(-14)), rs2941471 at 8q21.11 (HNF4G, P = 6.60 x 10(-10)), rs4795218 at 17q12 (HNF1B, P = 1.32 x 10(-8)), and rs1517037 at 18q21.32 (GRP, P = 3.28 x 10(-8)). rs78417682 is not statistically significantly associated with pancreatic cancer in PANDoRA. Expression quantitative trait locus analysis in three independent pancreatic data sets provides molecular support of NOC2L as a pancreatic cancer susceptibility gene.
Published: 2018
Full Text: View/download PDF

48. Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer

Author: Klein, Alison P., Wolpin, Brian M., Risch, Harvey A., Stolzenberg-Solomon, Rachael Z., Mocci, Evelina, Zhang, Mingfeng, Canzian, Federico, Childs, Erica J., Hoskins, Jason W., Jermusyk, Ashley, Zhong, Jun, Chen, Fei, Albanes, Demetrius, Andreotti, Gabriella, Arslan, Alan A., Babic, Ana, Bamlet, William R., Beane-Freeman, Laura, Berndt, Sonja I., Blackford, Amanda, Borges, Michael, Borgida, Ayelet, Bracci, Paige M., Brais, Lauren, Brennan, Paul, Brenner, Hermann, Bueno-de-Mesquita, Bas, Buring, Julie, Campa, Daniele, Capurso, Gabriele, Cavestro, Giulia Martina, Chaffee, Kari G., Chung, Charles C., Cleary, Sean, Cotterchio, Michelle, Dijk, Frederike, Duell, Eric J., Foretova, Lenka, Fuchs, Charles, Funel, Niccola, Gallinger, Steven, Gaziano, J. Michael M., Gazouli, Maria, Giles, Graham G., Giovannucci, Edward, Goggins, Michael, Goodman, Gary E., Goodman, Phyllis J., Hackert, Thilo, Haiman, Christopher, Hartge, Patricia, Hasan, Manal, Hegyi, Peter, Helzlsouer, Kathy J., Herman, Joseph, Holcatova, Ivana, Holly, Elizabeth A., Hoover, Robert, Hung, Rayjean J., Jacobs, Eric J., Jamroziak, Krzysztof, Janout, Vladimir, Kaaks, Rudolf, Khaw, Kay-Tee, Klein, Eric A., Kogevinas, Manolis, Kooperberg, Charles, Kulke, Matthew H., Kupcinskas, Juozas, Kurtz, Robert J., Laheru, Daniel, Landi, Stefano, Lawlor, Rita T., Lee, I. -Min, LeMarchand, Loic, Lu, Lingeng, Malats, Nuria, Mambrini, Andrea, Mannisto, Satu, Milne, Roger L., Mohelnikova-Duchonova, Beatrice, Neale, Rachel E., Neoptolemos, John P., Oberg, Ann L., Olson, Sara H., Orlow, Irene, Pasquali, Claudio, Patel, Alpa V., Peters, Ulrike, Pezzilli, Raffaele, Porta, Miquel, Real, Francisco X., Rothman, Nathaniel, Scelo, Ghislaine, Sesso, Howard D., Severi, Gianluca, Shu, Xiao-Ou, Silverman, Debra, Smith, Jill P., Soucek, Pavel, Sund, Malin, Talar-Wojnarowska, Renata, Tavano, Francesca, Thornquist, Mark D., Tobias, Geoffrey S., Van Den Eeden, Stephen K., Vashist, Yogesh, Visvanathan, Kala, Vodicka, Pavel, Wactawski-Wende, Jean, Wang, Zhaoming, Wentzensen, Nicolas, White, Emily, Yu, Herbert, Yu, Kai, Zeleniuch-Jacquotte, Anne, Zheng, Wei, Kraft, Peter, Li, Donghui, Chanock, Stephen, Obazee, Ofure, Petersen, Gloria M., Amundadottir, Laufey T., Klein, Alison P., Wolpin, Brian M., Risch, Harvey A., Stolzenberg-Solomon, Rachael Z., Mocci, Evelina, Zhang, Mingfeng, Canzian, Federico, Childs, Erica J., Hoskins, Jason W., Jermusyk, Ashley, Zhong, Jun, Chen, Fei, Albanes, Demetrius, Andreotti, Gabriella, Arslan, Alan A., Babic, Ana, Bamlet, William R., Beane-Freeman, Laura, Berndt, Sonja I., Blackford, Amanda, Borges, Michael, Borgida, Ayelet, Bracci, Paige M., Brais, Lauren, Brennan, Paul, Brenner, Hermann, Bueno-de-Mesquita, Bas, Buring, Julie, Campa, Daniele, Capurso, Gabriele, Cavestro, Giulia Martina, Chaffee, Kari G., Chung, Charles C., Cleary, Sean, Cotterchio, Michelle, Dijk, Frederike, Duell, Eric J., Foretova, Lenka, Fuchs, Charles, Funel, Niccola, Gallinger, Steven, Gaziano, J. Michael M., Gazouli, Maria, Giles, Graham G., Giovannucci, Edward, Goggins, Michael, Goodman, Gary E., Goodman, Phyllis J., Hackert, Thilo, Haiman, Christopher, Hartge, Patricia, Hasan, Manal, Hegyi, Peter, Helzlsouer, Kathy J., Herman, Joseph, Holcatova, Ivana, Holly, Elizabeth A., Hoover, Robert, Hung, Rayjean J., Jacobs, Eric J., Jamroziak, Krzysztof, Janout, Vladimir, Kaaks, Rudolf, Khaw, Kay-Tee, Klein, Eric A., Kogevinas, Manolis, Kooperberg, Charles, Kulke, Matthew H., Kupcinskas, Juozas, Kurtz, Robert J., Laheru, Daniel, Landi, Stefano, Lawlor, Rita T., Lee, I. -Min, LeMarchand, Loic, Lu, Lingeng, Malats, Nuria, Mambrini, Andrea, Mannisto, Satu, Milne, Roger L., Mohelnikova-Duchonova, Beatrice, Neale, Rachel E., Neoptolemos, John P., Oberg, Ann L., Olson, Sara H., Orlow, Irene, Pasquali, Claudio, Patel, Alpa V., Peters, Ulrike, Pezzilli, Raffaele, Porta, Miquel, Real, Francisco X., Rothman, Nathaniel, Scelo, Ghislaine, Sesso, Howard D., Severi, Gianluca, Shu, Xiao-Ou, Silverman, Debra, Smith, Jill P., Soucek, Pavel, Sund, Malin, Talar-Wojnarowska, Renata, Tavano, Francesca, Thornquist, Mark D., Tobias, Geoffrey S., Van Den Eeden, Stephen K., Vashist, Yogesh, Visvanathan, Kala, Vodicka, Pavel, Wactawski-Wende, Jean, Wang, Zhaoming, Wentzensen, Nicolas, White, Emily, Yu, Herbert, Yu, Kai, Zeleniuch-Jacquotte, Anne, Zheng, Wei, Kraft, Peter, Li, Donghui, Chanock, Stephen, Obazee, Ofure, Petersen, Gloria M., and Amundadottir, Laufey T.
Abstract: In 2020, 146,063 deaths due to pancreatic cancer are estimated to occur in Europe and the United States combined. To identify common susceptibility alleles, we performed the largest pancreatic cancer GWAS to date, including 9040 patients and 12,496 controls of European ancestry from the Pancreatic Cancer Cohort Consortium (PanScan) and the Pancreatic Cancer Case-Control Consortium (PanC4). Here, we find significant evidence of a novel association at rs78417682 (7p12/TNS3, P = 4.35 x 10(-8)). Replication of 10 promising signals in up to 2737 patients and 4752 controls from the PANcreatic Disease ReseArch (PAN-DoRA) consortium yields new genome-wide significant loci: rs13303010 at 1p36.33 (NOC2L, P = 8.36 x 10(-14)), rs2941471 at 8q21.11 (HNF4G, P = 6.60 x 10(-10)), rs4795218 at 17q12 (HNF1B, P = 1.32 x 10(-8)), and rs1517037 at 18q21.32 (GRP, P = 3.28 x 10(-8)). rs78417682 is not statistically significantly associated with pancreatic cancer in PANDoRA. Expression quantitative trait locus analysis in three independent pancreatic data sets provides molecular support of NOC2L as a pancreatic cancer susceptibility gene.
Published: 2018
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49. Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma

Author: Bernatsky, Sasha, Velásquez García, Héctor A, Spinelli, John, Gaffney, Patrick, Smedby, Karin E, Ramsey-Goldman, Rosalind, Wang, Sophia S., Adami, Hans-Olov, Albanes, Demetrius, Angelucci, Emanuele, Ansell, Stephen M., Asmann, Yan W., Becker, Nikolaus, Benavente, Yolanda, Berndt, Sonja I., Bertrand, Kimberly A., Birmann, Brenda M., Boeing, Heiner, Boffetta, Paolo, Bracci, Paige M., Brennan, Paul, Brooks-Wilson, Angela R., Cerhan, James R., Chanock, Stephen J., Clavel, Jacqueline, Conde, Lucia, Cotenbader, Karen H, Cox, David G, Cozen, Wendy, Crouch, Simon, De Roos, Anneclaire J., De Sanjose, Silvia, Di Lollo, Simonetta, Diver, W. Ryan, Dogan, Ahmet, Foretova, Lenka, Ghesquières, Hervé, Giles, Graham G., Glimelius, Bengt, Habermann, Thomas M., Haioun, Corinne, Hartge, Patricia, Hjalgrim, Henrik, Holford, Theodore R., Holly, Elizabeth A., Jackson, Rebecca D., Kaaks, Rudolph, Kane, Eleanor, Kelly, Rachel S., Klein, Robert J., Kraft, Peter, Kricker, Anne, Lan, Qing, Lawrence, Charles, Liebow, Mark, Lightfoot, Tracy, Link, Brian K., Maynadie, Marc, McKay, James, Melbye, Mads, Molina, Thierry Jo, Monnereau, Alain, Morton, Lindsay M., Nieters, Alexandra, North, Kari E., Novak, Anne J., Offit, Kenneth, Purdue, Mark P., Rais, Marco, Riby, Jacques, Roman, Eve, Rothman, Nathaniel, Salles, Gilles, Severi, Gianluca, Severson, Richard K., Skibola, Christine F., Slager, Susan L., Smith, Alex, Smith, Martyn T., Southey, Melissa C., Staines, Anthony, Teras, Lauren R., Thompson, Carrie A., Tilly, Hervé, Tinker, Lesley F., Tjonneland, Anne, Turner, Jenny, Vajdic, Claire M., Vermeulen, Roel C H, Vijai, Joseph, Vineis, Paolo, Virtamo, Jarmo, Wang, Zhaoming, Weinstein, Stephanie, Witzig, Thomas E., Zelenetz, Andrew, Zeleniuch-Jacquotte, Anne, Zhang, Yawei, Zheng, Tongzhang, Zucca, Mariagrazia, Clarke, Ann E, Bernatsky, Sasha, Velásquez García, Héctor A, Spinelli, John, Gaffney, Patrick, Smedby, Karin E, Ramsey-Goldman, Rosalind, Wang, Sophia S., Adami, Hans-Olov, Albanes, Demetrius, Angelucci, Emanuele, Ansell, Stephen M., Asmann, Yan W., Becker, Nikolaus, Benavente, Yolanda, Berndt, Sonja I., Bertrand, Kimberly A., Birmann, Brenda M., Boeing, Heiner, Boffetta, Paolo, Bracci, Paige M., Brennan, Paul, Brooks-Wilson, Angela R., Cerhan, James R., Chanock, Stephen J., Clavel, Jacqueline, Conde, Lucia, Cotenbader, Karen H, Cox, David G, Cozen, Wendy, Crouch, Simon, De Roos, Anneclaire J., De Sanjose, Silvia, Di Lollo, Simonetta, Diver, W. Ryan, Dogan, Ahmet, Foretova, Lenka, Ghesquières, Hervé, Giles, Graham G., Glimelius, Bengt, Habermann, Thomas M., Haioun, Corinne, Hartge, Patricia, Hjalgrim, Henrik, Holford, Theodore R., Holly, Elizabeth A., Jackson, Rebecca D., Kaaks, Rudolph, Kane, Eleanor, Kelly, Rachel S., Klein, Robert J., Kraft, Peter, Kricker, Anne, Lan, Qing, Lawrence, Charles, Liebow, Mark, Lightfoot, Tracy, Link, Brian K., Maynadie, Marc, McKay, James, Melbye, Mads, Molina, Thierry Jo, Monnereau, Alain, Morton, Lindsay M., Nieters, Alexandra, North, Kari E., Novak, Anne J., Offit, Kenneth, Purdue, Mark P., Rais, Marco, Riby, Jacques, Roman, Eve, Rothman, Nathaniel, Salles, Gilles, Severi, Gianluca, Severson, Richard K., Skibola, Christine F., Slager, Susan L., Smith, Alex, Smith, Martyn T., Southey, Melissa C., Staines, Anthony, Teras, Lauren R., Thompson, Carrie A., Tilly, Hervé, Tinker, Lesley F., Tjonneland, Anne, Turner, Jenny, Vajdic, Claire M., Vermeulen, Roel C H, Vijai, Joseph, Vineis, Paolo, Virtamo, Jarmo, Wang, Zhaoming, Weinstein, Stephanie, Witzig, Thomas E., Zelenetz, Andrew, Zeleniuch-Jacquotte, Anne, Zhang, Yawei, Zheng, Tongzhang, Zucca, Mariagrazia, and Clarke, Ann E
Abstract: Objective: Determinants of the increased risk of diffuse large B-cell lymphoma (DLBCL) in SLE are unclear. Using data from a recent lymphoma genome-wide association study (GWAS), we assessed whether certain lupus-related single nucleotide polymorphisms (SNPs) were also associated with DLBCL.Methods: GWAS data on European Caucasians from the International Lymphoma Epidemiology Consortium (InterLymph) provided a total of 3857 DLBCL cases and 7666 general-population controls. Data were pooled in a random-effects meta-analysis.Results: Among the 28 SLE-related SNPs investigated, the two most convincingly associated with risk of DLBCL included the CD40 SLE risk allele rs4810485 on chromosome 20q13 (OR per risk allele=1.09, 95% CI 1.02 to 1.16, p=0.0134), and the HLA SLE risk allele rs1270942 on chromosome 6p21.33 (OR per risk allele=1.17, 95% CI 1.01 to 1.36, p=0.0362). Of additional possible interest were rs2205960 and rs12537284. The rs2205960 SNP, related to a cytokine of the tumour necrosis factor superfamily TNFSF4, was associated with an OR per risk allele of 1.07, 95% CI 1.00 to 1.16, p=0.0549. The OR for the rs12537284 (chromosome 7q32, IRF5 gene) risk allele was 1.08, 95% CI 0.99 to 1.18, p=0.0765.Conclusions: These data suggest several plausible genetic links between DLBCL and SLE.
Published: 2017

50. Body Size Indicators and Risk of Gallbladder Cancer : Pooled Analysis of Individual-Level Data from 19 Prospective Cohort Studies.

Author: Campbell, Peter T, Newton, Christina C, Kitahara, Cari M, Patel, Alpa V, Hartge, Patricia, Koshiol, Jill, McGlynn, Katherine A, Adami, Hans-Olov, Berrington de González, Amy, Beane Freeman, Laura E, Bernstein, Leslie, Buring, Julie E, Freedman, Neal D, Gao, Yu-Tang, Giles, Graham G, Gunter, Marc J, Jenab, Mazda, Liao, Linda M, Milne, Roger L, Robien, Kim, Sandler, Dale P, Schairer, Catherine, Sesso, Howard D, Shu, Xiao-Ou, Weiderpass, Elisabete, Wolk, Alicja, Xiang, Yong-Bing, Zeleniuch-Jacquotte, Anne, Zheng, Wei, Gapstur, Susan M, Campbell, Peter T, Newton, Christina C, Kitahara, Cari M, Patel, Alpa V, Hartge, Patricia, Koshiol, Jill, McGlynn, Katherine A, Adami, Hans-Olov, Berrington de González, Amy, Beane Freeman, Laura E, Bernstein, Leslie, Buring, Julie E, Freedman, Neal D, Gao, Yu-Tang, Giles, Graham G, Gunter, Marc J, Jenab, Mazda, Liao, Linda M, Milne, Roger L, Robien, Kim, Sandler, Dale P, Schairer, Catherine, Sesso, Howard D, Shu, Xiao-Ou, Weiderpass, Elisabete, Wolk, Alicja, Xiang, Yong-Bing, Zeleniuch-Jacquotte, Anne, Zheng, Wei, and Gapstur, Susan M
Abstract: Background: There are few established risk factors for gallbladder cancer beyond gallstones. Recent studies suggest a higher risk with high body mass index (BMI), an indicator of general heaviness, but evidence from other body size measures is lacking.Methods: Associations of adult BMI, young adult BMI, height, adult weight gain, waist circumference (WC), waist-height ratio (WHtR), hip circumference (HC), and waist-hip ratio (WHR) with gallbladder cancer risk were evaluated. Individual-level data from 1,878,801 participants in 19 prospective cohort studies (14 studies had circumference measures) were harmonized and included in this analysis. Multivariable Cox proportional hazards regression estimated hazard ratios (HR) and 95% confidence intervals (CI).Results: After enrollment, 567 gallbladder cancer cases were identified during 20.1 million person-years of observation, including 361 cases with WC measures. Higher adult BMI (per 5 kg/m2, HR: 1.24; 95% CI, 1.13-1.35), young adult BMI (per 5 kg/m2, HR: 1.12; 95% CI, 1.00-1.26), adult weight gain (per 5 kg, HR: 1.07; 95% CI, 1.02-1.12), height (per 5 cm, HR: 1.10; 95% CI, 1.03-1.17), WC (per 5 cm, HR: 1.09; 95% CI, 1.02-1.17), WHtR (per 0.1 unit, HR: 1.24; 95% CI, 1.00-1.54), and HC (per 5 cm, HR: 1.13; 95% CI, 1.04-1.22), but not WHR (per 0.1 unit, HR: 1.03; 95% CI, 0.87-1.22), were associated with higher risks of gallbladder cancer, and results did not differ meaningfully by sex or other demographic/lifestyle factors.Conclusions: These findings indicate that measures of overall and central excess body weight are associated with higher gallbladder cancer risks.Impact: Excess body weight is an important, and potentially preventable, gallbladder cancer risk factor. Cancer Epidemiol Biomarkers Prev; 26(4); 597-606. ©2017 AACR.
Published: 2017
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