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1. Executive Summary: Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU.

Author

Devlin, John W, Devlin, John W, Skrobik, Yoanna, Gélinas, Céline, Needham, Dale M, Slooter, Arjen JC, Pandharipande, Pratik P, Watson, Paula L, Weinhouse, Gerald L, Nunnally, Mark E, Rochwerg, Bram, Balas, Michele C, van den Boogaard, Mark, Bosma, Karen J, Brummel, Nathaniel E, Chanques, Gerald, Denehy, Linda, Drouot, Xavier, Fraser, Gilles L, Harris, Jocelyn E, Joffe, Aaron M, Kho, Michelle E, Kress, John P, Lanphere, Julie A, McKinley, Sharon, Neufeld, Karin J, Pisani, Margaret A, Payen, Jean-Francois, Pun, Brenda T, Puntillo, Kathleen A, Riker, Richard R, Robinson, Bryce RH, Shehabi, Yahya, Szumita, Paul M, Winkelman, Chris, Centofanti, John E, Price, Carrie, Nikayin, Sina, Misak, Cheryl J, Flood, Pamela D, Kiedrowski, Ken, Alhazzani, Waleed, Devlin, John W, Devlin, John W, Skrobik, Yoanna, Gélinas, Céline, Needham, Dale M, Slooter, Arjen JC, Pandharipande, Pratik P, Watson, Paula L, Weinhouse, Gerald L, Nunnally, Mark E, Rochwerg, Bram, Balas, Michele C, van den Boogaard, Mark, Bosma, Karen J, Brummel, Nathaniel E, Chanques, Gerald, Denehy, Linda, Drouot, Xavier, Fraser, Gilles L, Harris, Jocelyn E, Joffe, Aaron M, Kho, Michelle E, Kress, John P, Lanphere, Julie A, McKinley, Sharon, Neufeld, Karin J, Pisani, Margaret A, Payen, Jean-Francois, Pun, Brenda T, Puntillo, Kathleen A, Riker, Richard R, Robinson, Bryce RH, Shehabi, Yahya, Szumita, Paul M, Winkelman, Chris, Centofanti, John E, Price, Carrie, Nikayin, Sina, Misak, Cheryl J, Flood, Pamela D, Kiedrowski, Ken, and Alhazzani, Waleed

Published
2018

2. Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU.

Author

Devlin, John W, Devlin, John W, Skrobik, Yoanna, Gélinas, Céline, Needham, Dale M, Slooter, Arjen JC, Pandharipande, Pratik P, Watson, Paula L, Weinhouse, Gerald L, Nunnally, Mark E, Rochwerg, Bram, Balas, Michele C, van den Boogaard, Mark, Bosma, Karen J, Brummel, Nathaniel E, Chanques, Gerald, Denehy, Linda, Drouot, Xavier, Fraser, Gilles L, Harris, Jocelyn E, Joffe, Aaron M, Kho, Michelle E, Kress, John P, Lanphere, Julie A, McKinley, Sharon, Neufeld, Karin J, Pisani, Margaret A, Payen, Jean-Francois, Pun, Brenda T, Puntillo, Kathleen A, Riker, Richard R, Robinson, Bryce RH, Shehabi, Yahya, Szumita, Paul M, Winkelman, Chris, Centofanti, John E, Price, Carrie, Nikayin, Sina, Misak, Cheryl J, Flood, Pamela D, Kiedrowski, Ken, Alhazzani, Waleed, Devlin, John W, Devlin, John W, Skrobik, Yoanna, Gélinas, Céline, Needham, Dale M, Slooter, Arjen JC, Pandharipande, Pratik P, Watson, Paula L, Weinhouse, Gerald L, Nunnally, Mark E, Rochwerg, Bram, Balas, Michele C, van den Boogaard, Mark, Bosma, Karen J, Brummel, Nathaniel E, Chanques, Gerald, Denehy, Linda, Drouot, Xavier, Fraser, Gilles L, Harris, Jocelyn E, Joffe, Aaron M, Kho, Michelle E, Kress, John P, Lanphere, Julie A, McKinley, Sharon, Neufeld, Karin J, Pisani, Margaret A, Payen, Jean-Francois, Pun, Brenda T, Puntillo, Kathleen A, Riker, Richard R, Robinson, Bryce RH, Shehabi, Yahya, Szumita, Paul M, Winkelman, Chris, Centofanti, John E, Price, Carrie, Nikayin, Sina, Misak, Cheryl J, Flood, Pamela D, Kiedrowski, Ken, and Alhazzani, Waleed

Abstract

OBJECTIVE:To update and expand the 2013 Clinical Practice Guidelines for the Management of Pain, Agitation, and Delirium in Adult Patients in the ICU. DESIGN:Thirty-two international experts, four methodologists, and four critical illness survivors met virtually at least monthly. All section groups gathered face-to-face at annual Society of Critical Care Medicine congresses; virtual connections included those unable to attend. A formal conflict of interest policy was developed a priori and enforced throughout the process. Teleconferences and electronic discussions among subgroups and whole panel were part of the guidelines' development. A general content review was completed face-to-face by all panel members in January 2017. METHODS:Content experts, methodologists, and ICU survivors were represented in each of the five sections of the guidelines: Pain, Agitation/sedation, Delirium, Immobility (mobilization/rehabilitation), and Sleep (disruption). Each section created Population, Intervention, Comparison, and Outcome, and nonactionable, descriptive questions based on perceived clinical relevance. The guideline group then voted their ranking, and patients prioritized their importance. For each Population, Intervention, Comparison, and Outcome question, sections searched the best available evidence, determined its quality, and formulated recommendations as "strong," "conditional," or "good" practice statements based on Grading of Recommendations Assessment, Development and Evaluation principles. In addition, evidence gaps and clinical caveats were explicitly identified. RESULTS:The Pain, Agitation/Sedation, Delirium, Immobility (mobilization/rehabilitation), and Sleep (disruption) panel issued 37 recommendations (three strong and 34 conditional), two good practice statements, and 32 ungraded, nonactionable statements. Three questions from the patient-centered prioritized question list remained without recommendation. CONCLUSIONS:We found substantial agreement among a l

Published
2018

3. Executive Summary : Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU

Author

Devlin, John W, Skrobik, Yoanna, Gélinas, Céline, Needham, Dale M, Slooter, Arjen J C, Pandharipande, Pratik P, Watson, Paula L, Weinhouse, Gerald L, Nunnally, Mark E, Rochwerg, Bram, Balas, Michele C, van den Boogaard, Mark, Bosma, Karen J, Brummel, Nathaniel E, Chanques, Gerald, Denehy, Linda, Drouot, Xavier, Fraser, Gilles L, Harris, Jocelyn E, Joffe, Aaron M, Kho, Michelle E, Kress, John P, Lanphere, Julie A, McKinley, Sharon, Neufeld, Karin J, Pisani, Margaret A, Payen, Jean-Francois, Pun, Brenda T, Puntillo, Kathleen A, Riker, Richard R, Robinson, Bryce R H, Shehabi, Yahya, Szumita, Paul M, Winkelman, Chris, Centofanti, John E, Price, Carrie, Nikayin, Sina, Misak, Cheryl J, Flood, Pamela D, Kiedrowski, Ken, Alhazzani, Waleed, Devlin, John W, Skrobik, Yoanna, Gélinas, Céline, Needham, Dale M, Slooter, Arjen J C, Pandharipande, Pratik P, Watson, Paula L, Weinhouse, Gerald L, Nunnally, Mark E, Rochwerg, Bram, Balas, Michele C, van den Boogaard, Mark, Bosma, Karen J, Brummel, Nathaniel E, Chanques, Gerald, Denehy, Linda, Drouot, Xavier, Fraser, Gilles L, Harris, Jocelyn E, Joffe, Aaron M, Kho, Michelle E, Kress, John P, Lanphere, Julie A, McKinley, Sharon, Neufeld, Karin J, Pisani, Margaret A, Payen, Jean-Francois, Pun, Brenda T, Puntillo, Kathleen A, Riker, Richard R, Robinson, Bryce R H, Shehabi, Yahya, Szumita, Paul M, Winkelman, Chris, Centofanti, John E, Price, Carrie, Nikayin, Sina, Misak, Cheryl J, Flood, Pamela D, Kiedrowski, Ken, and Alhazzani, Waleed

Published
2018

4. Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU

Author

Devlin, John W, Skrobik, Yoanna, Gélinas, Céline, Needham, Dale M, Slooter, Arjen J C, Pandharipande, Pratik P, Watson, Paula L, Weinhouse, Gerald L, Nunnally, Mark E, Rochwerg, Bram, Balas, Michele C, van den Boogaard, Mark, Bosma, Karen J, Brummel, Nathaniel E, Chanques, Gerald, Denehy, Linda, Drouot, Xavier, Fraser, Gilles L, Harris, Jocelyn E, Joffe, Aaron M, Kho, Michelle E, Kress, John P, Lanphere, Julie A, McKinley, Sharon, Neufeld, Karin J, Pisani, Margaret A, Payen, Jean-Francois, Pun, Brenda T, Puntillo, Kathleen A, Riker, Richard R, Robinson, Bryce R H, Shehabi, Yahya, Szumita, Paul M, Winkelman, Chris, Centofanti, John E, Price, Carrie, Nikayin, Sina, Misak, Cheryl J, Flood, Pamela D, Kiedrowski, Ken, Alhazzani, Waleed, Devlin, John W, Skrobik, Yoanna, Gélinas, Céline, Needham, Dale M, Slooter, Arjen J C, Pandharipande, Pratik P, Watson, Paula L, Weinhouse, Gerald L, Nunnally, Mark E, Rochwerg, Bram, Balas, Michele C, van den Boogaard, Mark, Bosma, Karen J, Brummel, Nathaniel E, Chanques, Gerald, Denehy, Linda, Drouot, Xavier, Fraser, Gilles L, Harris, Jocelyn E, Joffe, Aaron M, Kho, Michelle E, Kress, John P, Lanphere, Julie A, McKinley, Sharon, Neufeld, Karin J, Pisani, Margaret A, Payen, Jean-Francois, Pun, Brenda T, Puntillo, Kathleen A, Riker, Richard R, Robinson, Bryce R H, Shehabi, Yahya, Szumita, Paul M, Winkelman, Chris, Centofanti, John E, Price, Carrie, Nikayin, Sina, Misak, Cheryl J, Flood, Pamela D, Kiedrowski, Ken, and Alhazzani, Waleed

Published
2018

5. Executive Summary : Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU

Author

Devlin, John W, Skrobik, Yoanna, Gélinas, Céline, Needham, Dale M, Slooter, Arjen J C, Pandharipande, Pratik P, Watson, Paula L, Weinhouse, Gerald L, Nunnally, Mark E, Rochwerg, Bram, Balas, Michele C, van den Boogaard, Mark, Bosma, Karen J, Brummel, Nathaniel E, Chanques, Gerald, Denehy, Linda, Drouot, Xavier, Fraser, Gilles L, Harris, Jocelyn E, Joffe, Aaron M, Kho, Michelle E, Kress, John P, Lanphere, Julie A, McKinley, Sharon, Neufeld, Karin J, Pisani, Margaret A, Payen, Jean-Francois, Pun, Brenda T, Puntillo, Kathleen A, Riker, Richard R, Robinson, Bryce R H, Shehabi, Yahya, Szumita, Paul M, Winkelman, Chris, Centofanti, John E, Price, Carrie, Nikayin, Sina, Misak, Cheryl J, Flood, Pamela D, Kiedrowski, Ken, Alhazzani, Waleed, Devlin, John W, Skrobik, Yoanna, Gélinas, Céline, Needham, Dale M, Slooter, Arjen J C, Pandharipande, Pratik P, Watson, Paula L, Weinhouse, Gerald L, Nunnally, Mark E, Rochwerg, Bram, Balas, Michele C, van den Boogaard, Mark, Bosma, Karen J, Brummel, Nathaniel E, Chanques, Gerald, Denehy, Linda, Drouot, Xavier, Fraser, Gilles L, Harris, Jocelyn E, Joffe, Aaron M, Kho, Michelle E, Kress, John P, Lanphere, Julie A, McKinley, Sharon, Neufeld, Karin J, Pisani, Margaret A, Payen, Jean-Francois, Pun, Brenda T, Puntillo, Kathleen A, Riker, Richard R, Robinson, Bryce R H, Shehabi, Yahya, Szumita, Paul M, Winkelman, Chris, Centofanti, John E, Price, Carrie, Nikayin, Sina, Misak, Cheryl J, Flood, Pamela D, Kiedrowski, Ken, and Alhazzani, Waleed

Published
2018

6. Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU

Author

Devlin, John W, Skrobik, Yoanna, Gélinas, Céline, Needham, Dale M, Slooter, Arjen J C, Pandharipande, Pratik P, Watson, Paula L, Weinhouse, Gerald L, Nunnally, Mark E, Rochwerg, Bram, Balas, Michele C, van den Boogaard, Mark, Bosma, Karen J, Brummel, Nathaniel E, Chanques, Gerald, Denehy, Linda, Drouot, Xavier, Fraser, Gilles L, Harris, Jocelyn E, Joffe, Aaron M, Kho, Michelle E, Kress, John P, Lanphere, Julie A, McKinley, Sharon, Neufeld, Karin J, Pisani, Margaret A, Payen, Jean-Francois, Pun, Brenda T, Puntillo, Kathleen A, Riker, Richard R, Robinson, Bryce R H, Shehabi, Yahya, Szumita, Paul M, Winkelman, Chris, Centofanti, John E, Price, Carrie, Nikayin, Sina, Misak, Cheryl J, Flood, Pamela D, Kiedrowski, Ken, Alhazzani, Waleed, Devlin, John W, Skrobik, Yoanna, Gélinas, Céline, Needham, Dale M, Slooter, Arjen J C, Pandharipande, Pratik P, Watson, Paula L, Weinhouse, Gerald L, Nunnally, Mark E, Rochwerg, Bram, Balas, Michele C, van den Boogaard, Mark, Bosma, Karen J, Brummel, Nathaniel E, Chanques, Gerald, Denehy, Linda, Drouot, Xavier, Fraser, Gilles L, Harris, Jocelyn E, Joffe, Aaron M, Kho, Michelle E, Kress, John P, Lanphere, Julie A, McKinley, Sharon, Neufeld, Karin J, Pisani, Margaret A, Payen, Jean-Francois, Pun, Brenda T, Puntillo, Kathleen A, Riker, Richard R, Robinson, Bryce R H, Shehabi, Yahya, Szumita, Paul M, Winkelman, Chris, Centofanti, John E, Price, Carrie, Nikayin, Sina, Misak, Cheryl J, Flood, Pamela D, Kiedrowski, Ken, and Alhazzani, Waleed

Published
2018

7. Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU.

Author

Devlin, John W, Devlin, John W, Skrobik, Yoanna, Gélinas, Céline, Needham, Dale M, Slooter, Arjen JC, Pandharipande, Pratik P, Watson, Paula L, Weinhouse, Gerald L, Nunnally, Mark E, Rochwerg, Bram, Balas, Michele C, van den Boogaard, Mark, Bosma, Karen J, Brummel, Nathaniel E, Chanques, Gerald, Denehy, Linda, Drouot, Xavier, Fraser, Gilles L, Harris, Jocelyn E, Joffe, Aaron M, Kho, Michelle E, Kress, John P, Lanphere, Julie A, McKinley, Sharon, Neufeld, Karin J, Pisani, Margaret A, Payen, Jean-Francois, Pun, Brenda T, Puntillo, Kathleen A, Riker, Richard R, Robinson, Bryce RH, Shehabi, Yahya, Szumita, Paul M, Winkelman, Chris, Centofanti, John E, Price, Carrie, Nikayin, Sina, Misak, Cheryl J, Flood, Pamela D, Kiedrowski, Ken, Alhazzani, Waleed, Devlin, John W, Devlin, John W, Skrobik, Yoanna, Gélinas, Céline, Needham, Dale M, Slooter, Arjen JC, Pandharipande, Pratik P, Watson, Paula L, Weinhouse, Gerald L, Nunnally, Mark E, Rochwerg, Bram, Balas, Michele C, van den Boogaard, Mark, Bosma, Karen J, Brummel, Nathaniel E, Chanques, Gerald, Denehy, Linda, Drouot, Xavier, Fraser, Gilles L, Harris, Jocelyn E, Joffe, Aaron M, Kho, Michelle E, Kress, John P, Lanphere, Julie A, McKinley, Sharon, Neufeld, Karin J, Pisani, Margaret A, Payen, Jean-Francois, Pun, Brenda T, Puntillo, Kathleen A, Riker, Richard R, Robinson, Bryce RH, Shehabi, Yahya, Szumita, Paul M, Winkelman, Chris, Centofanti, John E, Price, Carrie, Nikayin, Sina, Misak, Cheryl J, Flood, Pamela D, Kiedrowski, Ken, and Alhazzani, Waleed

Abstract

ObjectiveTo update and expand the 2013 Clinical Practice Guidelines for the Management of Pain, Agitation, and Delirium in Adult Patients in the ICU.DesignThirty-two international experts, four methodologists, and four critical illness survivors met virtually at least monthly. All section groups gathered face-to-face at annual Society of Critical Care Medicine congresses; virtual connections included those unable to attend. A formal conflict of interest policy was developed a priori and enforced throughout the process. Teleconferences and electronic discussions among subgroups and whole panel were part of the guidelines' development. A general content review was completed face-to-face by all panel members in January 2017.MethodsContent experts, methodologists, and ICU survivors were represented in each of the five sections of the guidelines: Pain, Agitation/sedation, Delirium, Immobility (mobilization/rehabilitation), and Sleep (disruption). Each section created Population, Intervention, Comparison, and Outcome, and nonactionable, descriptive questions based on perceived clinical relevance. The guideline group then voted their ranking, and patients prioritized their importance. For each Population, Intervention, Comparison, and Outcome question, sections searched the best available evidence, determined its quality, and formulated recommendations as "strong," "conditional," or "good" practice statements based on Grading of Recommendations Assessment, Development and Evaluation principles. In addition, evidence gaps and clinical caveats were explicitly identified.ResultsThe Pain, Agitation/Sedation, Delirium, Immobility (mobilization/rehabilitation), and Sleep (disruption) panel issued 37 recommendations (three strong and 34 conditional), two good practice statements, and 32 ungraded, nonactionable statements. Three questions from the patient-centered prioritized question list remained without recommendation.ConclusionsWe found substantial agreement among a large, int

Published
2018

8. Executive Summary: Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU.

Author

Devlin, John W, Devlin, John W, Skrobik, Yoanna, Gélinas, Céline, Needham, Dale M, Slooter, Arjen JC, Pandharipande, Pratik P, Watson, Paula L, Weinhouse, Gerald L, Nunnally, Mark E, Rochwerg, Bram, Balas, Michele C, van den Boogaard, Mark, Bosma, Karen J, Brummel, Nathaniel E, Chanques, Gerald, Denehy, Linda, Drouot, Xavier, Fraser, Gilles L, Harris, Jocelyn E, Joffe, Aaron M, Kho, Michelle E, Kress, John P, Lanphere, Julie A, McKinley, Sharon, Neufeld, Karin J, Pisani, Margaret A, Payen, Jean-Francois, Pun, Brenda T, Puntillo, Kathleen A, Riker, Richard R, Robinson, Bryce RH, Shehabi, Yahya, Szumita, Paul M, Winkelman, Chris, Centofanti, John E, Price, Carrie, Nikayin, Sina, Misak, Cheryl J, Flood, Pamela D, Kiedrowski, Ken, Alhazzani, Waleed, Devlin, John W, Devlin, John W, Skrobik, Yoanna, Gélinas, Céline, Needham, Dale M, Slooter, Arjen JC, Pandharipande, Pratik P, Watson, Paula L, Weinhouse, Gerald L, Nunnally, Mark E, Rochwerg, Bram, Balas, Michele C, van den Boogaard, Mark, Bosma, Karen J, Brummel, Nathaniel E, Chanques, Gerald, Denehy, Linda, Drouot, Xavier, Fraser, Gilles L, Harris, Jocelyn E, Joffe, Aaron M, Kho, Michelle E, Kress, John P, Lanphere, Julie A, McKinley, Sharon, Neufeld, Karin J, Pisani, Margaret A, Payen, Jean-Francois, Pun, Brenda T, Puntillo, Kathleen A, Riker, Richard R, Robinson, Bryce RH, Shehabi, Yahya, Szumita, Paul M, Winkelman, Chris, Centofanti, John E, Price, Carrie, Nikayin, Sina, Misak, Cheryl J, Flood, Pamela D, Kiedrowski, Ken, and Alhazzani, Waleed

Published
2018

9. Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU

Author

Devlin, John W, Skrobik, Yoanna, Gélinas, Céline, Needham, Dale M, Slooter, Arjen J C, Pandharipande, Pratik P, Watson, Paula L, Weinhouse, Gerald L, Nunnally, Mark E, Rochwerg, Bram, Balas, Michele C, van den Boogaard, Mark, Bosma, Karen J, Brummel, Nathaniel E, Chanques, Gerald, Denehy, Linda, Drouot, Xavier, Fraser, Gilles L, Harris, Jocelyn E, Joffe, Aaron M, Kho, Michelle E, Kress, John P, Lanphere, Julie A, McKinley, Sharon, Neufeld, Karin J, Pisani, Margaret A, Payen, Jean-Francois, Pun, Brenda T, Puntillo, Kathleen A, Riker, Richard R, Robinson, Bryce R H, Shehabi, Yahya, Szumita, Paul M, Winkelman, Chris, Centofanti, John E, Price, Carrie, Nikayin, Sina, Misak, Cheryl J, Flood, Pamela D, Kiedrowski, Ken, Alhazzani, Waleed, Devlin, John W, Skrobik, Yoanna, Gélinas, Céline, Needham, Dale M, Slooter, Arjen J C, Pandharipande, Pratik P, Watson, Paula L, Weinhouse, Gerald L, Nunnally, Mark E, Rochwerg, Bram, Balas, Michele C, van den Boogaard, Mark, Bosma, Karen J, Brummel, Nathaniel E, Chanques, Gerald, Denehy, Linda, Drouot, Xavier, Fraser, Gilles L, Harris, Jocelyn E, Joffe, Aaron M, Kho, Michelle E, Kress, John P, Lanphere, Julie A, McKinley, Sharon, Neufeld, Karin J, Pisani, Margaret A, Payen, Jean-Francois, Pun, Brenda T, Puntillo, Kathleen A, Riker, Richard R, Robinson, Bryce R H, Shehabi, Yahya, Szumita, Paul M, Winkelman, Chris, Centofanti, John E, Price, Carrie, Nikayin, Sina, Misak, Cheryl J, Flood, Pamela D, Kiedrowski, Ken, and Alhazzani, Waleed

Published
2018

10. Executive Summary : Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU

Author

Devlin, John W, Skrobik, Yoanna, Gélinas, Céline, Needham, Dale M, Slooter, Arjen J C, Pandharipande, Pratik P, Watson, Paula L, Weinhouse, Gerald L, Nunnally, Mark E, Rochwerg, Bram, Balas, Michele C, van den Boogaard, Mark, Bosma, Karen J, Brummel, Nathaniel E, Chanques, Gerald, Denehy, Linda, Drouot, Xavier, Fraser, Gilles L, Harris, Jocelyn E, Joffe, Aaron M, Kho, Michelle E, Kress, John P, Lanphere, Julie A, McKinley, Sharon, Neufeld, Karin J, Pisani, Margaret A, Payen, Jean-Francois, Pun, Brenda T, Puntillo, Kathleen A, Riker, Richard R, Robinson, Bryce R H, Shehabi, Yahya, Szumita, Paul M, Winkelman, Chris, Centofanti, John E, Price, Carrie, Nikayin, Sina, Misak, Cheryl J, Flood, Pamela D, Kiedrowski, Ken, Alhazzani, Waleed, Devlin, John W, Skrobik, Yoanna, Gélinas, Céline, Needham, Dale M, Slooter, Arjen J C, Pandharipande, Pratik P, Watson, Paula L, Weinhouse, Gerald L, Nunnally, Mark E, Rochwerg, Bram, Balas, Michele C, van den Boogaard, Mark, Bosma, Karen J, Brummel, Nathaniel E, Chanques, Gerald, Denehy, Linda, Drouot, Xavier, Fraser, Gilles L, Harris, Jocelyn E, Joffe, Aaron M, Kho, Michelle E, Kress, John P, Lanphere, Julie A, McKinley, Sharon, Neufeld, Karin J, Pisani, Margaret A, Payen, Jean-Francois, Pun, Brenda T, Puntillo, Kathleen A, Riker, Richard R, Robinson, Bryce R H, Shehabi, Yahya, Szumita, Paul M, Winkelman, Chris, Centofanti, John E, Price, Carrie, Nikayin, Sina, Misak, Cheryl J, Flood, Pamela D, Kiedrowski, Ken, and Alhazzani, Waleed

Published
2018

11. Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU

Author

Medische Staf Intensive Care, Brain, Circulatory Health, Devlin, John W, Skrobik, Yoanna, Gélinas, Céline, Needham, Dale M, Slooter, Arjen J C, Pandharipande, Pratik P, Watson, Paula L, Weinhouse, Gerald L, Nunnally, Mark E, Rochwerg, Bram, Balas, Michele C, van den Boogaard, Mark, Bosma, Karen J, Brummel, Nathaniel E, Chanques, Gerald, Denehy, Linda, Drouot, Xavier, Fraser, Gilles L, Harris, Jocelyn E, Joffe, Aaron M, Kho, Michelle E, Kress, John P, Lanphere, Julie A, McKinley, Sharon, Neufeld, Karin J, Pisani, Margaret A, Payen, Jean-Francois, Pun, Brenda T, Puntillo, Kathleen A, Riker, Richard R, Robinson, Bryce R H, Shehabi, Yahya, Szumita, Paul M, Winkelman, Chris, Centofanti, John E, Price, Carrie, Nikayin, Sina, Misak, Cheryl J, Flood, Pamela D, Kiedrowski, Ken, Alhazzani, Waleed, Medische Staf Intensive Care, Brain, Circulatory Health, Devlin, John W, Skrobik, Yoanna, Gélinas, Céline, Needham, Dale M, Slooter, Arjen J C, Pandharipande, Pratik P, Watson, Paula L, Weinhouse, Gerald L, Nunnally, Mark E, Rochwerg, Bram, Balas, Michele C, van den Boogaard, Mark, Bosma, Karen J, Brummel, Nathaniel E, Chanques, Gerald, Denehy, Linda, Drouot, Xavier, Fraser, Gilles L, Harris, Jocelyn E, Joffe, Aaron M, Kho, Michelle E, Kress, John P, Lanphere, Julie A, McKinley, Sharon, Neufeld, Karin J, Pisani, Margaret A, Payen, Jean-Francois, Pun, Brenda T, Puntillo, Kathleen A, Riker, Richard R, Robinson, Bryce R H, Shehabi, Yahya, Szumita, Paul M, Winkelman, Chris, Centofanti, John E, Price, Carrie, Nikayin, Sina, Misak, Cheryl J, Flood, Pamela D, Kiedrowski, Ken, and Alhazzani, Waleed

Published
2018

12. Executive Summary: Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU

Author

Medische Staf Intensive Care, Brain, Circulatory Health, Devlin, John W, Skrobik, Yoanna, Gélinas, Céline, Needham, Dale M, Slooter, Arjen J C, Pandharipande, Pratik P, Watson, Paula L, Weinhouse, Gerald L, Nunnally, Mark E, Rochwerg, Bram, Balas, Michele C, van den Boogaard, Mark, Bosma, Karen J, Brummel, Nathaniel E, Chanques, Gerald, Denehy, Linda, Drouot, Xavier, Fraser, Gilles L, Harris, Jocelyn E, Joffe, Aaron M, Kho, Michelle E, Kress, John P, Lanphere, Julie A, McKinley, Sharon, Neufeld, Karin J, Pisani, Margaret A, Payen, Jean-Francois, Pun, Brenda T, Puntillo, Kathleen A, Riker, Richard R, Robinson, Bryce R H, Shehabi, Yahya, Szumita, Paul M, Winkelman, Chris, Centofanti, John E, Price, Carrie, Nikayin, Sina, Misak, Cheryl J, Flood, Pamela D, Kiedrowski, Ken, Alhazzani, Waleed, Medische Staf Intensive Care, Brain, Circulatory Health, Devlin, John W, Skrobik, Yoanna, Gélinas, Céline, Needham, Dale M, Slooter, Arjen J C, Pandharipande, Pratik P, Watson, Paula L, Weinhouse, Gerald L, Nunnally, Mark E, Rochwerg, Bram, Balas, Michele C, van den Boogaard, Mark, Bosma, Karen J, Brummel, Nathaniel E, Chanques, Gerald, Denehy, Linda, Drouot, Xavier, Fraser, Gilles L, Harris, Jocelyn E, Joffe, Aaron M, Kho, Michelle E, Kress, John P, Lanphere, Julie A, McKinley, Sharon, Neufeld, Karin J, Pisani, Margaret A, Payen, Jean-Francois, Pun, Brenda T, Puntillo, Kathleen A, Riker, Richard R, Robinson, Bryce R H, Shehabi, Yahya, Szumita, Paul M, Winkelman, Chris, Centofanti, John E, Price, Carrie, Nikayin, Sina, Misak, Cheryl J, Flood, Pamela D, Kiedrowski, Ken, and Alhazzani, Waleed

Published
2018

13. A formative evaluation of the implementation of an upper limb stroke rehabilitation intervention in clinical practice: a qualitative interview study

Author

Connell, Louise, McMahon, Naoimh, Harris, Jocelyn E, Watkins, Caroline Leigh, Eng, Janice J, Connell, Louise, McMahon, Naoimh, Harris, Jocelyn E, Watkins, Caroline Leigh, and Eng, Janice J

Abstract

Background: The Graded Repetitive Arm Supplementary Program (GRASP) is a hand and arm exercise programme designed to increase the intensity of exercise achieved in inpatient stroke rehabilitation. GRASP was shown to be effective in a randomised controlled trial in 2009 and has since experienced unusually rapid uptake into clinical practice. The aim of this study was to conduct a formative evaluation of the implementation of GRASP to inform the development and implementation of a similar intervention in the United Kingdom. Methods: Semi-structured interviews were conducted with therapists who were involved in implementing GRASP at their work site, or who had experience of using GRASP. Normalisation Process Theory (NPT), a sociological theory used to explore the processes of embedding innovations in practice, was used to develop an interview guide. Intervention components outlined within the GRASP Guideline Manual were used to develop prompts to explore how therapists use GRASP in practice. Interview transcripts were analysed using a coding frame based on implementation theory. Results: Twenty interviews were conducted across eight sites in British Columbia Canada. Therapists identified informal networks and the free online availability of GRASP as key factors in finding out about the intervention. All therapists reported positive opinions about the value of GRASP. At all sites, therapists identified individuals who advocated for the use of GRASP, and in six of the eight sites this was the practice leader or senior therapist. Rehabilitation assistants were identified as instrumental in delivering GRASP in almost all sites as they were responsible for organising the GRASP equipment and assisting patients using GRASP. Almost all intervention components were found to be adapted to some degree when used in clinical practice; coverage was wider, the content adapted, and the dose, when monitored, was less. Conclusions: Although GRASP has translated into clinical practice, i

Published
2014

14. A formative evaluation of the implementation of an upper limb stroke rehabilitation intervention in clinical practice: a qualitative interview study

Author

Connell, Louise, McMahon, Naoimh, Harris, Jocelyn E, Watkins, Caroline Leigh, Eng, Janice J, Connell, Louise, McMahon, Naoimh, Harris, Jocelyn E, Watkins, Caroline Leigh, and Eng, Janice J

Abstract

Background: The Graded Repetitive Arm Supplementary Program (GRASP) is a hand and arm exercise programme designed to increase the intensity of exercise achieved in inpatient stroke rehabilitation. GRASP was shown to be effective in a randomised controlled trial in 2009 and has since experienced unusually rapid uptake into clinical practice. The aim of this study was to conduct a formative evaluation of the implementation of GRASP to inform the development and implementation of a similar intervention in the United Kingdom. Methods: Semi-structured interviews were conducted with therapists who were involved in implementing GRASP at their work site, or who had experience of using GRASP. Normalisation Process Theory (NPT), a sociological theory used to explore the processes of embedding innovations in practice, was used to develop an interview guide. Intervention components outlined within the GRASP Guideline Manual were used to develop prompts to explore how therapists use GRASP in practice. Interview transcripts were analysed using a coding frame based on implementation theory. Results: Twenty interviews were conducted across eight sites in British Columbia Canada. Therapists identified informal networks and the free online availability of GRASP as key factors in finding out about the intervention. All therapists reported positive opinions about the value of GRASP. At all sites, therapists identified individuals who advocated for the use of GRASP, and in six of the eight sites this was the practice leader or senior therapist. Rehabilitation assistants were identified as instrumental in delivering GRASP in almost all sites as they were responsible for organising the GRASP equipment and assisting patients using GRASP. Almost all intervention components were found to be adapted to some degree when used in clinical practice; coverage was wider, the content adapted, and the dose, when monitored, was less. Conclusions: Although GRASP has translated into clinical practice, i

Published
2014

15. A formative evaluation of the implementation of an upper limb stroke rehabilitation intervention in clinical practice: a qualitative interview study

Author

Connell, Louise, McMahon, Naoimh, Harris, Jocelyn E, Watkins, Caroline Leigh, Eng, Janice J, Connell, Louise, McMahon, Naoimh, Harris, Jocelyn E, Watkins, Caroline Leigh, and Eng, Janice J

Abstract

Background: The Graded Repetitive Arm Supplementary Program (GRASP) is a hand and arm exercise programme designed to increase the intensity of exercise achieved in inpatient stroke rehabilitation. GRASP was shown to be effective in a randomised controlled trial in 2009 and has since experienced unusually rapid uptake into clinical practice. The aim of this study was to conduct a formative evaluation of the implementation of GRASP to inform the development and implementation of a similar intervention in the United Kingdom. Methods: Semi-structured interviews were conducted with therapists who were involved in implementing GRASP at their work site, or who had experience of using GRASP. Normalisation Process Theory (NPT), a sociological theory used to explore the processes of embedding innovations in practice, was used to develop an interview guide. Intervention components outlined within the GRASP Guideline Manual were used to develop prompts to explore how therapists use GRASP in practice. Interview transcripts were analysed using a coding frame based on implementation theory. Results: Twenty interviews were conducted across eight sites in British Columbia Canada. Therapists identified informal networks and the free online availability of GRASP as key factors in finding out about the intervention. All therapists reported positive opinions about the value of GRASP. At all sites, therapists identified individuals who advocated for the use of GRASP, and in six of the eight sites this was the practice leader or senior therapist. Rehabilitation assistants were identified as instrumental in delivering GRASP in almost all sites as they were responsible for organising the GRASP equipment and assisting patients using GRASP. Almost all intervention components were found to be adapted to some degree when used in clinical practice; coverage was wider, the content adapted, and the dose, when monitored, was less. Conclusions: Although GRASP has translated into clinical practice, i

Published
2014

16. A formative evaluation of the implementation of an upper limb stroke rehabilitation intervention in clinical practice: a qualitative interview study

Author

Connell, Louise, McMahon, Naoimh, Harris, Jocelyn E, Watkins, Caroline Leigh, Eng, Janice J, Connell, Louise, McMahon, Naoimh, Harris, Jocelyn E, Watkins, Caroline Leigh, and Eng, Janice J

Abstract

Background: The Graded Repetitive Arm Supplementary Program (GRASP) is a hand and arm exercise programme designed to increase the intensity of exercise achieved in inpatient stroke rehabilitation. GRASP was shown to be effective in a randomised controlled trial in 2009 and has since experienced unusually rapid uptake into clinical practice. The aim of this study was to conduct a formative evaluation of the implementation of GRASP to inform the development and implementation of a similar intervention in the United Kingdom. Methods: Semi-structured interviews were conducted with therapists who were involved in implementing GRASP at their work site, or who had experience of using GRASP. Normalisation Process Theory (NPT), a sociological theory used to explore the processes of embedding innovations in practice, was used to develop an interview guide. Intervention components outlined within the GRASP Guideline Manual were used to develop prompts to explore how therapists use GRASP in practice. Interview transcripts were analysed using a coding frame based on implementation theory. Results: Twenty interviews were conducted across eight sites in British Columbia Canada. Therapists identified informal networks and the free online availability of GRASP as key factors in finding out about the intervention. All therapists reported positive opinions about the value of GRASP. At all sites, therapists identified individuals who advocated for the use of GRASP, and in six of the eight sites this was the practice leader or senior therapist. Rehabilitation assistants were identified as instrumental in delivering GRASP in almost all sites as they were responsible for organising the GRASP equipment and assisting patients using GRASP. Almost all intervention components were found to be adapted to some degree when used in clinical practice; coverage was wider, the content adapted, and the dose, when monitored, was less. Conclusions: Although GRASP has translated into clinical practice, i

Published
2014

17. A formative evaluation of the implementation of an upper limb stroke rehabilitation intervention in clinical practice: a qualitative interview study

Author

Connell, Louise, McMahon, Naoimh, Harris, Jocelyn E, Watkins, Caroline Leigh, Eng, Janice J, Connell, Louise, McMahon, Naoimh, Harris, Jocelyn E, Watkins, Caroline Leigh, and Eng, Janice J

Abstract

Background: The Graded Repetitive Arm Supplementary Program (GRASP) is a hand and arm exercise programme designed to increase the intensity of exercise achieved in inpatient stroke rehabilitation. GRASP was shown to be effective in a randomised controlled trial in 2009 and has since experienced unusually rapid uptake into clinical practice. The aim of this study was to conduct a formative evaluation of the implementation of GRASP to inform the development and implementation of a similar intervention in the United Kingdom. Methods: Semi-structured interviews were conducted with therapists who were involved in implementing GRASP at their work site, or who had experience of using GRASP. Normalisation Process Theory (NPT), a sociological theory used to explore the processes of embedding innovations in practice, was used to develop an interview guide. Intervention components outlined within the GRASP Guideline Manual were used to develop prompts to explore how therapists use GRASP in practice. Interview transcripts were analysed using a coding frame based on implementation theory. Results: Twenty interviews were conducted across eight sites in British Columbia Canada. Therapists identified informal networks and the free online availability of GRASP as key factors in finding out about the intervention. All therapists reported positive opinions about the value of GRASP. At all sites, therapists identified individuals who advocated for the use of GRASP, and in six of the eight sites this was the practice leader or senior therapist. Rehabilitation assistants were identified as instrumental in delivering GRASP in almost all sites as they were responsible for organising the GRASP equipment and assisting patients using GRASP. Almost all intervention components were found to be adapted to some degree when used in clinical practice; coverage was wider, the content adapted, and the dose, when monitored, was less. Conclusions: Although GRASP has translated into clinical practice, i

Published
2014

18. A formative evaluation of the implementation of an upper limb stroke rehabilitation intervention in clinical practice: a qualitative interview study

Author

Connell, Louise, McMahon, Naoimh, Harris, Jocelyn E, Watkins, Caroline Leigh, Eng, Janice J, Connell, Louise, McMahon, Naoimh, Harris, Jocelyn E, Watkins, Caroline Leigh, and Eng, Janice J

Abstract

Background: The Graded Repetitive Arm Supplementary Program (GRASP) is a hand and arm exercise programme designed to increase the intensity of exercise achieved in inpatient stroke rehabilitation. GRASP was shown to be effective in a randomised controlled trial in 2009 and has since experienced unusually rapid uptake into clinical practice. The aim of this study was to conduct a formative evaluation of the implementation of GRASP to inform the development and implementation of a similar intervention in the United Kingdom. Methods: Semi-structured interviews were conducted with therapists who were involved in implementing GRASP at their work site, or who had experience of using GRASP. Normalisation Process Theory (NPT), a sociological theory used to explore the processes of embedding innovations in practice, was used to develop an interview guide. Intervention components outlined within the GRASP Guideline Manual were used to develop prompts to explore how therapists use GRASP in practice. Interview transcripts were analysed using a coding frame based on implementation theory. Results: Twenty interviews were conducted across eight sites in British Columbia Canada. Therapists identified informal networks and the free online availability of GRASP as key factors in finding out about the intervention. All therapists reported positive opinions about the value of GRASP. At all sites, therapists identified individuals who advocated for the use of GRASP, and in six of the eight sites this was the practice leader or senior therapist. Rehabilitation assistants were identified as instrumental in delivering GRASP in almost all sites as they were responsible for organising the GRASP equipment and assisting patients using GRASP. Almost all intervention components were found to be adapted to some degree when used in clinical practice; coverage was wider, the content adapted, and the dose, when monitored, was less. Conclusions: Although GRASP has translated into clinical practice, i

Published
2014

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