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2,560 results on '"Halliday"'

1. Inconsistencies within the proposed framework for stabilizing fungal nomenclature risk further confusion

Author: Kidd, Sarah E., Hagen, Ferry, Halliday, Catriona L., Abdolrasouli, Alireza, Boekhout, Teun, Crous, Pedro W., Ellis, David H., Elvy, Juliet, Forrest, Graeme N., Groenewald, Marizeth, Hahn, Rosane C., Houbraken, Jos, Rodrigues, Anderson M., Scott, James, Sorrell, Tania C., Summerbell, Richard C., Tsui, Clement K.M., Yurkov, Andrey, Chen, Sharon C.A., Kidd, Sarah E., Hagen, Ferry, Halliday, Catriona L., Abdolrasouli, Alireza, Boekhout, Teun, Crous, Pedro W., Ellis, David H., Elvy, Juliet, Forrest, Graeme N., Groenewald, Marizeth, Hahn, Rosane C., Houbraken, Jos, Rodrigues, Anderson M., Scott, James, Sorrell, Tania C., Summerbell, Richard C., Tsui, Clement K.M., Yurkov, Andrey, and Chen, Sharon C.A.
Published: 2024

2. In situ estimation of ice crystal properties at the South Pole using LED calibration data from the IceCube Neutrino Observatory

Author: Abbasi, Rasha, Ackermann, Markus, Adams, Jenni, Aggarwal, Nakul, Aguilar, Juanan, Ahlers, Markus, Ahrens, Maryon, Alameddine, Jean-Marco, Alves Junior, Antonio Augusto, Amin, Najia Moureen Binte, Andeen, Karen, Anderson, Tyler, Anton, Gisela, Argüelles, Carlos, Ashida, Yosuke, Athanasiadou, Sofia, Axani, Spencer, Bai, Xinhua, Balagopal V, Aswathi, Baricevic, Moreno, Barwick, Steve, Basu, Vedant, Bay, Ryan, Beatty, James, Becker, Karl Heinz, Becker Tjus, Julia, Beise, Jakob, Bellenghi, Chiara, Benda, Samuel, BenZvi, Segev, Berley, David, Bernardini, Elisa, Besson, Dave, Binder, Gary, Bindig, Daniel, Blaufuss, Erik, Blot, Summer, Bontempo, Federico, Book, Julia, Borowka, Jürgen, Boscolo Meneguolo, Caterina, Böser, Sebastian, Botner, Olga, Böttcher, Jakob, Bourbeau, Etienne, Braun, Jim, Brinson, Bennett, Brostean-Kaiser, Jannes, Burley, Ryan, Busse, Raffaela, Campana, Michael, Carnie-Bronca, Erin, Chen, Chujie, Chen, Zheyang, Chirkin, Dmitry, Choi, Koun, Clark, Brian, Classen, Lew, Coleman, Alan, Collin, Gabriel, Connolly, Amy, Conrad, Janet, Coppin, Paul, Correa, Pablo, Countryman, Stefan, Cowen, Doug, Cross, Robert, Dappen, Christian, Dave, Pranav, De Clercq, Catherine, DeLaunay, James, Delgado López, Diyaselis, Dembinski, Hans, Deoskar, Kunal, Desai, Abhishek, Desiati, Paolo, de Vries, Krijn, de Wasseige, Gwenhael, DeYoung, Tyce, Diaz, Alejandro, Díaz-Vélez, Juan Carlos, Dittmer, Markus, Dujmovic, Hrvoje, DuVernois, Michael, Ehrhardt, Thomas, Eller, Philipp, Engel, Ralph, Erpenbeck, Hannah, Evans, John, Evenson, Paul, Fan, Kwok Lung, Fazely, Ali, Fedynitch, Anatoli, Feigl, Nora, Fiedlschuster, Sebastian, Fienberg, Aaron, Finley, Chad, Fischer, Leander, Fox, Derek, Franckowiak, Anna, Friedman, Elizabeth, Fritz, Alexander, Fürst, Philipp, Gaisser, Tom, Gallagher, Jay, Ganster, Erik, Garcia, Alfonso, Garrappa, Simone, Gerhardt, Lisa, Ghadimi, Ava, Glaser, Christian, Glüsenkamp, Thorsten, Glauch, Theo, Goehlke, Noah, Gonzalez, Javier, Goswami, Sreetama, Grant, Darren, Gray, Shannon, Grégoire, Timothée, Griswold, Spencer, Günther, Christoph, Gutjahr, Pascal, Haack, Christian, Hallgren, Allan, Halliday, Robert, Halve, Lasse, Halzen, Francis, Hamdaoui, Hassane, Ha Minh, Martin, Hanson, Kael, Hardin, John, Harnisch, Alexander, Hatch, Patrick, Haungs, Andreas, Helbing, Klaus, Hellrung, Jonas, Henningsen, Felix, Heuermann, Lars, Hickford, Stephanie, Hill, Colton, Hill, Gary, Hoffman, Kara, Hoshina, Kotoyo, Hou, Wenjie, Huber, Thomas, Hultqvist, Klas, Hünnefeld, Mirco, Hussain, Raamis, Hymon, Karolin, In, Seongjin, Iovine, Nadege, Ishihara, Aya, Jansson, Matti, Japaridze, George, Jeong, Minjin, Jin, Miaochen, Jones, Ben, Kang, Donghwa, Kang, Woosik, Kang, Xinyue, Kappes, Alexander, Kappesser, David, Kardum, Leonora, Karg, Timo, Karl, Martina, Karle, Albrecht, Katz, Uli, Kauer, Matt, Kelley, John, Kheirandish, Ali, Kin, Ken'ichi, Kiryluk, Joanna, Klein, Spencer, Kochocki, Alina, Koirala, Ramesh, Kolanoski, Hermann, Kontrimas, Tomas, Köpke, Lutz, Kopper, Claudio, Koskinen, Jason, Koundal, Paras, Kovacevich, Michael, Kowalski, Marek, Kozynets, Tetiana, Krupczak, Emmett, Kun, Emma, Kurahashi, Naoko, Lad, Neha, Lagunas Gualda, Cristina, Larson, Michael, Lauber, Frederik, Lazar, Jeffrey, Lee, Jiwoong, Leonard, Kayla, Leszczyńska, Agnieszka, Lincetto, Massimiliano, Liu, Qinrui, Liubarska, Maria, Lohfink, Elisa, Love, Christina, Lozano Mariscal, Cristian Jesus, Lu, Lu, Lucarelli, Francesco, Ludwig, Andrew, Luszczak, William, Lyu, Yang, Ma, Wing Yan, Madsen, Jim, Mahn, Kendall, Makino, Yuya, Mancina, Sarah, Marie Sainte, Wenceslas, Mariş, Ioana, Marka, Szabolcs, Marka, Zsuzsa, Marsee, Matthew, Martinez-Soler, Ivan, Maruyama, Reina, McElroy, Thomas, McNally, Frank, Mead, James Vincent, Meagher, Kevin, Mechbal, Sarah, Medina, Andres, Meier, Maximilian, Meighen-Berger, Stephan, Merckx, Yarno, Micallef, Jessie, Mockler, Daniela, Montaruli, Teresa, Moore, Roger, Morse, Bob, Moulai, Marjon, Mukherjee, Tista, Naab, Richard, Nagai, Ryo, Naumann, Uwe, Nayerhoda, Amid, Necker, Jannis, Neumann, Miriam, Niederhausen, Hans, Nisa, Mehr, Nowicki, Sarah, Obertacke Pollmann, Anna, Oehler, Marie, Oeyen, Bob, Olivas, Alex, Orsoe, Rasmus, Osborn, Jesse, O'Sullivan, Erin, Pandya, Hershal, Pankova, Daria, Park, Nahee, Parker, Grant, Paudel, Ek Narayan, Paul, Larissa, Pérez de los Heros, Carlos, Peters, Lilly, Peterson, Josh, Philippen, Saskia, Pieper, Sarah, Pizzuto, Alex, Plum, Matthias, Popovych, Yuiry, Porcelli, Alessio, Prado Rodriguez, Maria, Pries, Brandon, Procter-Murphy, Rachel, Przybylski, Gerald, Raab, Christoph, Rack-Helleis, John, Rameez, Mohamed, Rawlins, Katherine, Rechav, Zoe, Rehman, Abdul, Reichherzer, Patrick, Renzi, Giovanni, Resconi, Elisa, Reusch, Simeon, Rhode, Wolfgang, Richman, Mike, Riedel, Benedikt, Roberts, Ella, Robertson, Sally, Rodan, Steven, Roellinghoff, Gerrit, Rongen, Martin, Rott, Carsten, Ruhe, Tim, Ruohan, Li, Ryckbosch, Dirk, Rysewyk Cantu, Devyn, Safa, Ibrahim, Saffer, Julian, Salazar-Gallegos, Daniel, Sampathkumar, Pranav, Sanchez Herrera, Sebastian, Sandrock, Alexander, Santander, Marcos, Sarkar, Sourav, Sarkar, Subir, Schaufel, Merlin, Schieler, Harald, Schindler, Sebastian, Schlüter, Berit, Schmidt, Torsten, Schneider, Judith, Schröder, Frank, Schumacher, Lisa, Schwefer, Georg, Sclafani, Steve, Seckel, Dave, Seunarine, Surujhdeo, Sharma, Ankur, Shefali, Shefali, Shimizu, Nobuhiro, Silva, Manuel, Skrzypek, Barbara, Smithers, Ben, Snihur, Robert, Soedingrekso, Jan, Søgaard, Andreas, Soldin, Dennis, Spannfellner, Christian, Spiczak, Glenn, Spiering, Christian, Stamatikos, Michael, Stanev, Todor, Stein, Robert, Stezelberger, Thorsten, Stürwald, Timo, Stuttard, Thomas, Sullivan, Greg, Taboada, Ignacio, Ter-Antonyan, Samvel, Thompson, Will, Thwaites, Jessie, Tilav, Serap, Tollefson, Kirsten, Tönnis, Christoph, Toscano, Simona, Tosi, Delia, Trettin, Alexander, Tung, Chun Fai, Turcotte, Roxanne, Twagirayezu, Jean Pierre, Ty, Bunheng, Unland Elorrieta, Martin, Upshaw, Karriem, Valtonen-Mattila, Nora, Vandenbroucke, Justin, van Eijndhoven, Nick, Vannerom, David, van Santen, Jakob, Vara, Javi, Veitch-Michaelis, Joshua, Verpoest, Stef, Veske, Doga, Walck, Christian, Wang, Winnie, Watson, Timothy Blake, Weaver, Chris, Weigel, Philip, Weindl, Andreas, Weldert, Jan, Wendt, Chris, Werthebach, Johannes, Weyrauch, Mark, Whitehorn, Nathan, Wiebusch, Christopher, Willey, Nathan, Williams, Dawn, Wolf, Martin, Wrede, Gerrit, Wulff, Johan, Xu, Xianwu, Yanez, Juan Pablo, Yildizci, Emre, Yoshida, Shigeru, Yu, Shiqi, Yuan, Tianlu, Zhang, Zelong, Zhelnin, Pavel, Abbasi, Rasha, Ackermann, Markus, Adams, Jenni, Aggarwal, Nakul, Aguilar, Juanan, Ahlers, Markus, Ahrens, Maryon, Alameddine, Jean-Marco, Alves Junior, Antonio Augusto, Amin, Najia Moureen Binte, Andeen, Karen, Anderson, Tyler, Anton, Gisela, Argüelles, Carlos, Ashida, Yosuke, Athanasiadou, Sofia, Axani, Spencer, Bai, Xinhua, Balagopal V, Aswathi, Baricevic, Moreno, Barwick, Steve, Basu, Vedant, Bay, Ryan, Beatty, James, Becker, Karl Heinz, Becker Tjus, Julia, Beise, Jakob, Bellenghi, Chiara, Benda, Samuel, BenZvi, Segev, Berley, David, Bernardini, Elisa, Besson, Dave, Binder, Gary, Bindig, Daniel, Blaufuss, Erik, Blot, Summer, Bontempo, Federico, Book, Julia, Borowka, Jürgen, Boscolo Meneguolo, Caterina, Böser, Sebastian, Botner, Olga, Böttcher, Jakob, Bourbeau, Etienne, Braun, Jim, Brinson, Bennett, Brostean-Kaiser, Jannes, Burley, Ryan, Busse, Raffaela, Campana, Michael, Carnie-Bronca, Erin, Chen, Chujie, Chen, Zheyang, Chirkin, Dmitry, Choi, Koun, Clark, Brian, Classen, Lew, Coleman, Alan, Collin, Gabriel, Connolly, Amy, Conrad, Janet, Coppin, Paul, Correa, Pablo, Countryman, Stefan, Cowen, Doug, Cross, Robert, Dappen, Christian, Dave, Pranav, De Clercq, Catherine, DeLaunay, James, Delgado López, Diyaselis, Dembinski, Hans, Deoskar, Kunal, Desai, Abhishek, Desiati, Paolo, de Vries, Krijn, de Wasseige, Gwenhael, DeYoung, Tyce, Diaz, Alejandro, Díaz-Vélez, Juan Carlos, Dittmer, Markus, Dujmovic, Hrvoje, DuVernois, Michael, Ehrhardt, Thomas, Eller, Philipp, Engel, Ralph, Erpenbeck, Hannah, Evans, John, Evenson, Paul, Fan, Kwok Lung, Fazely, Ali, Fedynitch, Anatoli, Feigl, Nora, Fiedlschuster, Sebastian, Fienberg, Aaron, Finley, Chad, Fischer, Leander, Fox, Derek, Franckowiak, Anna, Friedman, Elizabeth, Fritz, Alexander, Fürst, Philipp, Gaisser, Tom, Gallagher, Jay, Ganster, Erik, Garcia, Alfonso, Garrappa, Simone, Gerhardt, Lisa, Ghadimi, Ava, Glaser, Christian, Glüsenkamp, Thorsten, Glauch, Theo, Goehlke, Noah, Gonzalez, Javier, Goswami, Sreetama, Grant, Darren, Gray, Shannon, Grégoire, Timothée, Griswold, Spencer, Günther, Christoph, Gutjahr, Pascal, Haack, Christian, Hallgren, Allan, Halliday, Robert, Halve, Lasse, Halzen, Francis, Hamdaoui, Hassane, Ha Minh, Martin, Hanson, Kael, Hardin, John, Harnisch, Alexander, Hatch, Patrick, Haungs, Andreas, Helbing, Klaus, Hellrung, Jonas, Henningsen, Felix, Heuermann, Lars, Hickford, Stephanie, Hill, Colton, Hill, Gary, Hoffman, Kara, Hoshina, Kotoyo, Hou, Wenjie, Huber, Thomas, Hultqvist, Klas, Hünnefeld, Mirco, Hussain, Raamis, Hymon, Karolin, In, Seongjin, Iovine, Nadege, Ishihara, Aya, Jansson, Matti, Japaridze, George, Jeong, Minjin, Jin, Miaochen, Jones, Ben, Kang, Donghwa, Kang, Woosik, Kang, Xinyue, Kappes, Alexander, Kappesser, David, Kardum, Leonora, Karg, Timo, Karl, Martina, Karle, Albrecht, Katz, Uli, Kauer, Matt, Kelley, John, Kheirandish, Ali, Kin, Ken'ichi, Kiryluk, Joanna, Klein, Spencer, Kochocki, Alina, Koirala, Ramesh, Kolanoski, Hermann, Kontrimas, Tomas, Köpke, Lutz, Kopper, Claudio, Koskinen, Jason, Koundal, Paras, Kovacevich, Michael, Kowalski, Marek, Kozynets, Tetiana, Krupczak, Emmett, Kun, Emma, Kurahashi, Naoko, Lad, Neha, Lagunas Gualda, Cristina, Larson, Michael, Lauber, Frederik, Lazar, Jeffrey, Lee, Jiwoong, Leonard, Kayla, Leszczyńska, Agnieszka, Lincetto, Massimiliano, Liu, Qinrui, Liubarska, Maria, Lohfink, Elisa, Love, Christina, Lozano Mariscal, Cristian Jesus, Lu, Lu, Lucarelli, Francesco, Ludwig, Andrew, Luszczak, William, Lyu, Yang, Ma, Wing Yan, Madsen, Jim, Mahn, Kendall, Makino, Yuya, Mancina, Sarah, Marie Sainte, Wenceslas, Mariş, Ioana, Marka, Szabolcs, Marka, Zsuzsa, Marsee, Matthew, Martinez-Soler, Ivan, Maruyama, Reina, McElroy, Thomas, McNally, Frank, Mead, James Vincent, Meagher, Kevin, Mechbal, Sarah, Medina, Andres, Meier, Maximilian, Meighen-Berger, Stephan, Merckx, Yarno, Micallef, Jessie, Mockler, Daniela, Montaruli, Teresa, Moore, Roger, Morse, Bob, Moulai, Marjon, Mukherjee, Tista, Naab, Richard, Nagai, Ryo, Naumann, Uwe, Nayerhoda, Amid, Necker, Jannis, Neumann, Miriam, Niederhausen, Hans, Nisa, Mehr, Nowicki, Sarah, Obertacke Pollmann, Anna, Oehler, Marie, Oeyen, Bob, Olivas, Alex, Orsoe, Rasmus, Osborn, Jesse, O'Sullivan, Erin, Pandya, Hershal, Pankova, Daria, Park, Nahee, Parker, Grant, Paudel, Ek Narayan, Paul, Larissa, Pérez de los Heros, Carlos, Peters, Lilly, Peterson, Josh, Philippen, Saskia, Pieper, Sarah, Pizzuto, Alex, Plum, Matthias, Popovych, Yuiry, Porcelli, Alessio, Prado Rodriguez, Maria, Pries, Brandon, Procter-Murphy, Rachel, Przybylski, Gerald, Raab, Christoph, Rack-Helleis, John, Rameez, Mohamed, Rawlins, Katherine, Rechav, Zoe, Rehman, Abdul, Reichherzer, Patrick, Renzi, Giovanni, Resconi, Elisa, Reusch, Simeon, Rhode, Wolfgang, Richman, Mike, Riedel, Benedikt, Roberts, Ella, Robertson, Sally, Rodan, Steven, Roellinghoff, Gerrit, Rongen, Martin, Rott, Carsten, Ruhe, Tim, Ruohan, Li, Ryckbosch, Dirk, Rysewyk Cantu, Devyn, Safa, Ibrahim, Saffer, Julian, Salazar-Gallegos, Daniel, Sampathkumar, Pranav, Sanchez Herrera, Sebastian, Sandrock, Alexander, Santander, Marcos, Sarkar, Sourav, Sarkar, Subir, Schaufel, Merlin, Schieler, Harald, Schindler, Sebastian, Schlüter, Berit, Schmidt, Torsten, Schneider, Judith, Schröder, Frank, Schumacher, Lisa, Schwefer, Georg, Sclafani, Steve, Seckel, Dave, Seunarine, Surujhdeo, Sharma, Ankur, Shefali, Shefali, Shimizu, Nobuhiro, Silva, Manuel, Skrzypek, Barbara, Smithers, Ben, Snihur, Robert, Soedingrekso, Jan, Søgaard, Andreas, Soldin, Dennis, Spannfellner, Christian, Spiczak, Glenn, Spiering, Christian, Stamatikos, Michael, Stanev, Todor, Stein, Robert, Stezelberger, Thorsten, Stürwald, Timo, Stuttard, Thomas, Sullivan, Greg, Taboada, Ignacio, Ter-Antonyan, Samvel, Thompson, Will, Thwaites, Jessie, Tilav, Serap, Tollefson, Kirsten, Tönnis, Christoph, Toscano, Simona, Tosi, Delia, Trettin, Alexander, Tung, Chun Fai, Turcotte, Roxanne, Twagirayezu, Jean Pierre, Ty, Bunheng, Unland Elorrieta, Martin, Upshaw, Karriem, Valtonen-Mattila, Nora, Vandenbroucke, Justin, van Eijndhoven, Nick, Vannerom, David, van Santen, Jakob, Vara, Javi, Veitch-Michaelis, Joshua, Verpoest, Stef, Veske, Doga, Walck, Christian, Wang, Winnie, Watson, Timothy Blake, Weaver, Chris, Weigel, Philip, Weindl, Andreas, Weldert, Jan, Wendt, Chris, Werthebach, Johannes, Weyrauch, Mark, Whitehorn, Nathan, Wiebusch, Christopher, Willey, Nathan, Williams, Dawn, Wolf, Martin, Wrede, Gerrit, Wulff, Johan, Xu, Xianwu, Yanez, Juan Pablo, Yildizci, Emre, Yoshida, Shigeru, Yu, Shiqi, Yuan, Tianlu, Zhang, Zelong, and Zhelnin, Pavel
Abstract: The IceCube Neutrino Observatory instruments about 1 km3 of deep, glacial ice at the geographic South Pole. It uses 5160 photomultipliers to detect Cherenkov light emitted by charged relativistic particles. An unexpected light propagation effect observed by the experiment is an anisotropic attenuation, which is aligned with the local flow direction of the ice. We examine birefringent light propagation through the polycrystalline ice microstructure as a possible explanation for this effect. The predictions of a first-principles model developed for this purpose, in particular curved light trajectories resulting from asymmetric diffusion, provide a qualitatively good match to the main features of the data. This in turn allows us to deduce ice crystal properties. Since the wavelength of the detected light is short compared to the crystal size, these crystal properties include not only the crystal orientation fabric, but also the average crystal size and shape, as a function of depth. By adding small empirical corrections to this first-principles model, a quantitatively accurate description of the optical properties of the IceCube glacial ice is obtained. In this paper, we present the experimental signature of ice optical anisotropy observed in IceCube light-emitting diode (LED) calibration data, the theory and parameterization of the birefringence effect, the fitting procedures of these parameterizations to experimental data, and the inferred crystal properties., Peer Reviewed
Published: 2024

3. Genome-wide analyses reveal a potential role for the MAPT, MOBP, and APOE loci in sporadic frontotemporal dementia.

Author: Manzoni, Claudia, Manzoni, Claudia, Kia, Demis, Ferrari, Raffaele, Leonenko, Ganna, Costa, Beatrice, Saba, Valentina, Jabbari, Edwin, Tan, Manuela, Albani, Diego, Alvarez, Victoria, Alvarez, Ignacio, Andreassen, Ole, Angiolillo, Antonella, Arighi, Andrea, Baker, Matt, Benussi, Luisa, Bessi, Valentina, Binetti, Giuliano, Blackburn, Daniel, Boada, Merce, Boeve, Bradley, Borrego-Ecija, Sergi, Borroni, Barbara, Bråthen, Geir, Brooks, William, Bruni, Amalia, Caroppo, Paola, Bandres-Ciga, Sara, Clarimon, Jordi, Colao, Rosanna, Cruchaga, Carlos, Danek, Adrian, de Boer, Sterre, de Rojas, Itziar, di Costanzo, Alfonso, Dickson, Dennis, Diehl-Schmid, Janine, Dobson-Stone, Carol, Dols-Icardo, Oriol, Donizetti, Aldo, Dopper, Elise, Durante, Elisabetta, Ferrari, Camilla, Forloni, Gianluigi, Frangipane, Francesca, Fratiglioni, Laura, Kramberger, Milica, Galimberti, Daniela, Gallucci, Maurizio, García-González, Pablo, Ghidoni, Roberta, Giaccone, Giorgio, Graff, Caroline, Graff-Radford, Neill, Grafman, Jordan, Halliday, Glenda, Hernandez, Dena, Hjermind, Lena, Hodges, John, Holloway, Guy, Huey, Edward, Illán-Gala, Ignacio, Josephs, Keith, Knopman, David, Kristiansen, Mark, Kwok, John, Leber, Isabelle, Leonard, Hampton, Libri, Ilenia, Lleo, Alberto, Mackenzie, Ian, Madhan, Gaganjit, Maletta, Raffaele, Marquié, Marta, Maver, Ales, Menendez-Gonzalez, Manuel, Milan, Graziella, Miller, Bruce, Morris, Christopher, Morris, Huw, Nacmias, Benedetta, Newton, Judith, Nielsen, Jørgen, Nilsson, Christer, Novelli, Valeria, Padovani, Alessandro, Pal, Suvankar, Pasquier, Florence, Pastor, Pau, Perneczky, Robert, Peterlin, Borut, Petersen, Ronald, Piguet, Olivier, Pijnenburg, Yolande, Puca, Annibale, Rademakers, Rosa, Rainero, Innocenzo, Reus, Lianne, Richardson, Anna, Riemenschneider, Matthias, Manzoni, Claudia, Manzoni, Claudia, Kia, Demis, Ferrari, Raffaele, Leonenko, Ganna, Costa, Beatrice, Saba, Valentina, Jabbari, Edwin, Tan, Manuela, Albani, Diego, Alvarez, Victoria, Alvarez, Ignacio, Andreassen, Ole, Angiolillo, Antonella, Arighi, Andrea, Baker, Matt, Benussi, Luisa, Bessi, Valentina, Binetti, Giuliano, Blackburn, Daniel, Boada, Merce, Boeve, Bradley, Borrego-Ecija, Sergi, Borroni, Barbara, Bråthen, Geir, Brooks, William, Bruni, Amalia, Caroppo, Paola, Bandres-Ciga, Sara, Clarimon, Jordi, Colao, Rosanna, Cruchaga, Carlos, Danek, Adrian, de Boer, Sterre, de Rojas, Itziar, di Costanzo, Alfonso, Dickson, Dennis, Diehl-Schmid, Janine, Dobson-Stone, Carol, Dols-Icardo, Oriol, Donizetti, Aldo, Dopper, Elise, Durante, Elisabetta, Ferrari, Camilla, Forloni, Gianluigi, Frangipane, Francesca, Fratiglioni, Laura, Kramberger, Milica, Galimberti, Daniela, Gallucci, Maurizio, García-González, Pablo, Ghidoni, Roberta, Giaccone, Giorgio, Graff, Caroline, Graff-Radford, Neill, Grafman, Jordan, Halliday, Glenda, Hernandez, Dena, Hjermind, Lena, Hodges, John, Holloway, Guy, Huey, Edward, Illán-Gala, Ignacio, Josephs, Keith, Knopman, David, Kristiansen, Mark, Kwok, John, Leber, Isabelle, Leonard, Hampton, Libri, Ilenia, Lleo, Alberto, Mackenzie, Ian, Madhan, Gaganjit, Maletta, Raffaele, Marquié, Marta, Maver, Ales, Menendez-Gonzalez, Manuel, Milan, Graziella, Miller, Bruce, Morris, Christopher, Morris, Huw, Nacmias, Benedetta, Newton, Judith, Nielsen, Jørgen, Nilsson, Christer, Novelli, Valeria, Padovani, Alessandro, Pal, Suvankar, Pasquier, Florence, Pastor, Pau, Perneczky, Robert, Peterlin, Borut, Petersen, Ronald, Piguet, Olivier, Pijnenburg, Yolande, Puca, Annibale, Rademakers, Rosa, Rainero, Innocenzo, Reus, Lianne, Richardson, Anna, and Riemenschneider, Matthias
Abstract: Frontotemporal dementia (FTD) is the second most common cause of early-onset dementia after Alzheimer disease (AD). Efforts in the field mainly focus on familial forms of disease (fFTDs), while studies of the genetic etiology of sporadic FTD (sFTD) have been less common. In the current work, we analyzed 4,685 sFTD cases and 15,308 controls looking for common genetic determinants for sFTD. We found a cluster of variants at the MAPT (rs199443; p = 2.5 × 10-12, OR = 1.27) and APOE (rs6857; p = 1.31 × 10-12, OR = 1.27) loci and a candidate locus on chromosome 3 (rs1009966; p = 2.41 × 10-8, OR = 1.16) in the intergenic region between RPSA and MOBP, contributing to increased risk for sFTD through effects on expression and/or splicing in brain cortex of functionally relevant in-cis genes at the MAPT and RPSA-MOBP loci. The association with the MAPT (H1c clade) and RPSA-MOBP loci may suggest common genetic pleiotropy across FTD and progressive supranuclear palsy (PSP) (MAPT and RPSA-MOBP loci) and across FTD, AD, Parkinson disease (PD), and cortico-basal degeneration (CBD) (MAPT locus). Our data also suggest population specificity of the risk signals, with MAPT and APOE loci associations mainly driven by Central/Nordic and Mediterranean Europeans, respectively. This study lays the foundations for future work aimed at further characterizing population-specific features of potential FTD-discriminant APOE haplotype(s) and the functional involvement and contribution of the MAPT H1c haplotype and RPSA-MOBP loci to pathogenesis of sporadic forms of FTD in brain cortex.
Published: 2024

4. Green Cities Initiative: integrated support for more resilient and food secure cities

Author: Halliday, J. and Halliday, J.
Abstract: Launched in 2020, the FAO’s flagship Green Cities Initiative (GCI) focuses on improving the urban environment, strengthening urban-rural linkages and strengthening the resilience of urban food systems, services, and populations to external shocks, through integrated management and planning of green spaces and agrifood systems.
Published: 2024

5. Inconsistencies within the proposed framework for stabilizing fungal nomenclature risk further confusion

Author: MMB, MMB Medische Staf, Kidd, Sarah E., Hagen, Ferry, Halliday, Catriona L., Abdolrasouli, Alireza, Boekhout, Teun, Crous, Pedro W., Ellis, David H., Elvy, Juliet, Forrest, Graeme N., Groenewald, Marizeth, Hahn, Rosane C., Houbraken, Jos, Rodrigues, Anderson M., Scott, James, Sorrell, Tania C., Summerbell, Richard C., Tsui, Clement K.M., Yurkov, Andrey, Chen, Sharon C.A., MMB, MMB Medische Staf, Kidd, Sarah E., Hagen, Ferry, Halliday, Catriona L., Abdolrasouli, Alireza, Boekhout, Teun, Crous, Pedro W., Ellis, David H., Elvy, Juliet, Forrest, Graeme N., Groenewald, Marizeth, Hahn, Rosane C., Houbraken, Jos, Rodrigues, Anderson M., Scott, James, Sorrell, Tania C., Summerbell, Richard C., Tsui, Clement K.M., Yurkov, Andrey, and Chen, Sharon C.A.
Published: 2024

6. Trazodone rescues dysregulated synaptic and mitochondrial nascent proteomes in prion neurodegeneration

Author: Albert-Gasco, Hector, Smith, Heather L., Álvarez Castelao, Beatriz, Swinden, Dean, Halliday, Mark, Janaki-Raman, Sudha, Butcher, Adrian J., Mallucci, Giovanna R., Albert-Gasco, Hector, Smith, Heather L., Álvarez Castelao, Beatriz, Swinden, Dean, Halliday, Mark, Janaki-Raman, Sudha, Butcher, Adrian J., and Mallucci, Giovanna R.
Abstract: The unfolded protein response (UPR) is rapidly gaining momentum as a therapeutic target for protein misfolding neurodegenerative diseases, in which its overactivation results in sustained translational repression leading to synapse loss and neurodegeneration. In mouse models of these disorders, from Alzheimer’s to prion disease, modulation of the pathway—including by the licensed drug, trazodone—restores global protein synthesis rates with profound neuroprotective effects. However, the precise nature of the translational impairment, in particular the specific proteins affected in disease, and their response to therapeutic UPR modulation are poorly understood. We used non-canonical amino acid tagging (NCAT) to measure de novo protein synthesis in the brains of prion-diseased mice with and without trazodone treatment, in both whole hippocampus and cell-specifically. During disease the predominant nascent proteome changes occur in synaptic, cytoskeletal and mitochondrial proteins in both hippocampal neurons and astrocytes. Remarkably, trazodone treatment for just 2 weeks largely restored the whole disease nascent proteome in the hippocampus to that of healthy, uninfected mice, predominantly with recovery of proteins involved in synaptic and mitochondrial function. In parallel, trazodone treatment restored the disease-associated decline in synapses and mitochondria and their function to wild-type levels. In conclusion, this study increases our understanding of how translational repression contributes to neurodegeneration through synaptic and mitochondrial toxicity via depletion of key proteins essential for their function. Further, it provides new insights into the neuroprotective mechanisms of trazodone through reversal of this toxicity, relevant for the treatment of neurodegenerative diseases via translational modulation., Sección Deptal. de Bioquímica y Biología Molecular (Veterinaria), Fac. de Veterinaria, TRUE, pub
Published: 2024

7. Genome-wide analyses reveal a potential role for the MAPT, MOBP, and APOE loci in sporadic frontotemporal dementia

Author: Manzoni, Claudia, Kia, Demis A., Ferrari, Raffaele, Leonenko, Ganna, Costa, Beatrice, Saba, Valentina, Jabbari, Edwin, Tan, Manuela MX, Albani, Diego, Alvarez, Victoria, Alvarez, Ignacio, Andreassen, Ole A., Angiolillo, Antonella, Arighi, Andrea, Baker, Matt, Benussi, Luisa, Bessi, Valentina, Binetti, Giuliano, Blackburn, Daniel J., Boada, Merce, Boeve, Bradley F., Borrego-Ecija, Sergi, Borroni, Barbara, Bråthen, Geir, Brooks, William S., Bruni, Amalia C., Caroppo, Paola, Bandres-Ciga, Sara, Clarimon, Jordi, Colao, Rosanna, Cruchaga, Carlos, Danek, Adrian, de Boer, Sterre CM, de Rojas, Itziar, di Costanzo, Alfonso, Dickson, Dennis W., Diehl-Schmid, Janine, Dobson-Stone, Carol, Dols-Icardo, Oriol, Donizetti, Aldo, Dopper, Elise, Durante, Elisabetta, Ferrari, Camilla, Forloni, Gianluigi, Frangipane, Francesca, Fratiglioni, Laura, Kramberger, Milica G., Galimberti, Daniela, Gallucci, Maurizio, García-González, Pablo, Ghidoni, Roberta, Giaccone, Giorgio, Graff, Caroline, Graff-Radford, Neill R., Grafman, Jordan, Halliday, Glenda M., Hernandez, Dena G., Hjermind, Lena E., Hodges, John R., Holloway, Guy, Huey, Edward D., Illán-Gala, Ignacio, Josephs, Keith A., Knopman, David S., Kristiansen, Mark, Kwok, John B., Leber, Isabelle, Leonard, Hampton L., Libri, Ilenia, Lleo, Alberto, Mackenzie, Ian R., Madhan, Gaganjit K., Maletta, Raffaele, Marquié, Marta, Maver, Ales, Menendez-Gonzalez, Manuel, Milan, Graziella, Miller, Bruce L., Morris, Christopher M., Morris, Huw R., Nacmias, Benedetta, Newton, Judith, Nielsen, Jørgen E., Nilsson, Christer, Novelli, Valeria, Padovani, Alessandro, Pal, Suvankar, Pasquier, Florence, Pastor, Pau, Perneczky, Robert, Peterlin, Borut, Petersen, Ronald C., Piguet, Olivier, Pijnenburg, Yolande AL, Puca, Annibale A., Rademakers, Rosa, Rainero, Innocenzo, Reus, Lianne M., Richardson, Anna MT, Riemenschneider, Matthias, Rogaeva, Ekaterina, Rogelj, Boris, Rollinson, Sara, Rosen, Howard, Rossi, Giacomina, Rowe, James B., Rubino, Elisa, Ruiz, Agustin, Salvi, Erika, Sanchez-Valle, Raquel, Sando, Sigrid Botne, Santillo, Alexander F., Saxon, Jennifer A., Schlachetzki, Johannes CM, Scholz, Sonja W., Seelaar, Harro, Seeley, William W., Serpente, Maria, Sorbi, Sandro, Sordon, Sabrina, St George-Hyslop, Peter, Thompson, Jennifer C., Van Broeckhoven, Christine, Van Deerlin, Vivianna M., Van der Lee, Sven J., Van Swieten, John, Tagliavini, Fabrizio, van der Zee, Julie, Veronesi, Arianna, Vitale, Emilia, Waldo, Maria Landqvist, Yokoyama, Jennifer S., Nalls, Mike A., Momeni, Parastoo, Singleton, Andrew B., Hardy, John, Escott-Price, Valentina, Manzoni, Claudia, Kia, Demis A., Ferrari, Raffaele, Leonenko, Ganna, Costa, Beatrice, Saba, Valentina, Jabbari, Edwin, Tan, Manuela MX, Albani, Diego, Alvarez, Victoria, Alvarez, Ignacio, Andreassen, Ole A., Angiolillo, Antonella, Arighi, Andrea, Baker, Matt, Benussi, Luisa, Bessi, Valentina, Binetti, Giuliano, Blackburn, Daniel J., Boada, Merce, Boeve, Bradley F., Borrego-Ecija, Sergi, Borroni, Barbara, Bråthen, Geir, Brooks, William S., Bruni, Amalia C., Caroppo, Paola, Bandres-Ciga, Sara, Clarimon, Jordi, Colao, Rosanna, Cruchaga, Carlos, Danek, Adrian, de Boer, Sterre CM, de Rojas, Itziar, di Costanzo, Alfonso, Dickson, Dennis W., Diehl-Schmid, Janine, Dobson-Stone, Carol, Dols-Icardo, Oriol, Donizetti, Aldo, Dopper, Elise, Durante, Elisabetta, Ferrari, Camilla, Forloni, Gianluigi, Frangipane, Francesca, Fratiglioni, Laura, Kramberger, Milica G., Galimberti, Daniela, Gallucci, Maurizio, García-González, Pablo, Ghidoni, Roberta, Giaccone, Giorgio, Graff, Caroline, Graff-Radford, Neill R., Grafman, Jordan, Halliday, Glenda M., Hernandez, Dena G., Hjermind, Lena E., Hodges, John R., Holloway, Guy, Huey, Edward D., Illán-Gala, Ignacio, Josephs, Keith A., Knopman, David S., Kristiansen, Mark, Kwok, John B., Leber, Isabelle, Leonard, Hampton L., Libri, Ilenia, Lleo, Alberto, Mackenzie, Ian R., Madhan, Gaganjit K., Maletta, Raffaele, Marquié, Marta, Maver, Ales, Menendez-Gonzalez, Manuel, Milan, Graziella, Miller, Bruce L., Morris, Christopher M., Morris, Huw R., Nacmias, Benedetta, Newton, Judith, Nielsen, Jørgen E., Nilsson, Christer, Novelli, Valeria, Padovani, Alessandro, Pal, Suvankar, Pasquier, Florence, Pastor, Pau, Perneczky, Robert, Peterlin, Borut, Petersen, Ronald C., Piguet, Olivier, Pijnenburg, Yolande AL, Puca, Annibale A., Rademakers, Rosa, Rainero, Innocenzo, Reus, Lianne M., Richardson, Anna MT, Riemenschneider, Matthias, Rogaeva, Ekaterina, Rogelj, Boris, Rollinson, Sara, Rosen, Howard, Rossi, Giacomina, Rowe, James B., Rubino, Elisa, Ruiz, Agustin, Salvi, Erika, Sanchez-Valle, Raquel, Sando, Sigrid Botne, Santillo, Alexander F., Saxon, Jennifer A., Schlachetzki, Johannes CM, Scholz, Sonja W., Seelaar, Harro, Seeley, William W., Serpente, Maria, Sorbi, Sandro, Sordon, Sabrina, St George-Hyslop, Peter, Thompson, Jennifer C., Van Broeckhoven, Christine, Van Deerlin, Vivianna M., Van der Lee, Sven J., Van Swieten, John, Tagliavini, Fabrizio, van der Zee, Julie, Veronesi, Arianna, Vitale, Emilia, Waldo, Maria Landqvist, Yokoyama, Jennifer S., Nalls, Mike A., Momeni, Parastoo, Singleton, Andrew B., Hardy, John, and Escott-Price, Valentina
Abstract: Frontotemporal dementia (FTD) is the second most common cause of early-onset dementia after Alzheimer disease (AD). Efforts in the field mainly focus on familial forms of disease (fFTDs), while studies of the genetic etiology of sporadic FTD (sFTD) have been less common. In the current work, we analyzed 4,685 sFTD cases and 15,308 controls looking for common genetic determinants for sFTD. We found a cluster of variants at the MAPT (rs199443; p = 2.5 × 10−12, OR = 1.27) and APOE (rs6857; p = 1.31 × 10−12, OR = 1.27) loci and a candidate locus on chromosome 3 (rs1009966; p = 2.41 × 10−8, OR = 1.16) in the intergenic region between RPSA and MOBP, contributing to increased risk for sFTD through effects on expression and/or splicing in brain cortex of functionally relevant in-cis genes at the MAPT and RPSA-MOBP loci. The association with the MAPT (H1c clade) and RPSA-MOBP loci may suggest common genetic pleiotropy across FTD and progressive supranuclear palsy (PSP) (MAPT and RPSA-MOBP loci) and across FTD, AD, Parkinson disease (PD), and cortico-basal degeneration (CBD) (MAPT locus). Our data also suggest population specificity of the risk signals, with MAPT and APOE loci associations mainly driven by Central/Nordic and Mediterranean Europeans, respectively. This study lays the foundations for future work aimed at further characterizing population-specific features of potential FTD-discriminant APOE haplotype(s) and the functional involvement and contribution of the MAPT H1c haplotype and RPSA-MOBP loci to pathogenesis of sporadic forms of FTD in brain cortex.
Published: 2024

8. Design, Synthesis, and Evaluation of New 1H-Benzo[d]imidazole Based PqsR Inhibitors as Adjuvant Therapy for Pseudomonas aeruginosa Infections

Author: Soukarieh, Fadi, Mashabi, Alaa, Richardson, William, Oton, Eduard Vico, Romero, Manuel, Dubern, Jean-Frederic, Robertson, Shaun N., Lucanto, Simone, Markham-Lee, Zoe, Sou, Tomás, Kukavica-Ibrulj, Irena, Levesque, Roger C., Bergström, Christel, Halliday, Nigel, Kellam, Barrie, Emsley, Jonas, Heeb, Stephan, Williams, Paul, Stocks, Michael J., Camara, Miguel, Soukarieh, Fadi, Mashabi, Alaa, Richardson, William, Oton, Eduard Vico, Romero, Manuel, Dubern, Jean-Frederic, Robertson, Shaun N., Lucanto, Simone, Markham-Lee, Zoe, Sou, Tomás, Kukavica-Ibrulj, Irena, Levesque, Roger C., Bergström, Christel, Halliday, Nigel, Kellam, Barrie, Emsley, Jonas, Heeb, Stephan, Williams, Paul, Stocks, Michael J., and Camara, Miguel
Abstract: Pseudomonas aeruginosa is one of the top priority pathogens that requires immediate attention according to the World Health Organisation (WHO). Due to the alarming shortage of novel antimicrobials, targeting quorum sensing (QS), a bacterial cell to cell signaling system controlling virulence, has emerged as a promising approach as an antibiotic adjuvant therapy. Interference with the pqs system, one of three QS systems in P. aeruginosa, results in reduction of bacterial virulence gene expression and biofilm maturation. Herein, we report a hit to lead process to fine-tune the potency of our previously reported inhibitor 1 (IC50 3.2 mu M in P. aeruginosa PAO1-L), which led to the discovery of 2-(4-(3-((6-chloro-1-isopropyl-1H-benzo[d]imidazol-2-yl)amino)-2-hydroxypropoxy)phenyl)acetonitrile (6f) as a potent PqsR antagonist. Compound 6f inhibited the PqsR-controlled P-pqsA-lux transcriptional reporter fusion in P. aeruginosa at low submicromolar concentrations. Moreover, 6f showed improved efficacy against P. aeruginosa CF isolates with significant inhibition of pyocyanin, 2-alkyl-4(1H)-quinolones production.
Published: 2024
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9. Design, Synthesis, and Evaluation of New 1H-Benzo[d]imidazole Based PqsR Inhibitors as Adjuvant Therapy for Pseudomonas aeruginosa Infections

Author: Soukarieh, Fadi, Mashabi, Alaa, Richardson, William, Oton, Eduard Vico, Romero, Manuel, Dubern, Jean-Frederic, Robertson, Shaun N., Lucanto, Simone, Markham-Lee, Zoe, Sou, Tomás, Kukavica-Ibrulj, Irena, Levesque, Roger C., Bergström, Christel, Halliday, Nigel, Kellam, Barrie, Emsley, Jonas, Heeb, Stephan, Williams, Paul, Stocks, Michael J., Camara, Miguel, Soukarieh, Fadi, Mashabi, Alaa, Richardson, William, Oton, Eduard Vico, Romero, Manuel, Dubern, Jean-Frederic, Robertson, Shaun N., Lucanto, Simone, Markham-Lee, Zoe, Sou, Tomás, Kukavica-Ibrulj, Irena, Levesque, Roger C., Bergström, Christel, Halliday, Nigel, Kellam, Barrie, Emsley, Jonas, Heeb, Stephan, Williams, Paul, Stocks, Michael J., and Camara, Miguel
Abstract: Pseudomonas aeruginosa is one of the top priority pathogens that requires immediate attention according to the World Health Organisation (WHO). Due to the alarming shortage of novel antimicrobials, targeting quorum sensing (QS), a bacterial cell to cell signaling system controlling virulence, has emerged as a promising approach as an antibiotic adjuvant therapy. Interference with the pqs system, one of three QS systems in P. aeruginosa, results in reduction of bacterial virulence gene expression and biofilm maturation. Herein, we report a hit to lead process to fine-tune the potency of our previously reported inhibitor 1 (IC50 3.2 mu M in P. aeruginosa PAO1-L), which led to the discovery of 2-(4-(3-((6-chloro-1-isopropyl-1H-benzo[d]imidazol-2-yl)amino)-2-hydroxypropoxy)phenyl)acetonitrile (6f) as a potent PqsR antagonist. Compound 6f inhibited the PqsR-controlled P-pqsA-lux transcriptional reporter fusion in P. aeruginosa at low submicromolar concentrations. Moreover, 6f showed improved efficacy against P. aeruginosa CF isolates with significant inhibition of pyocyanin, 2-alkyl-4(1H)-quinolones production.
Published: 2024
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10. Laboratory realization of relativistic pair-plasma beams

Author: Arrowsmith, C. D., Simon, P., Bilbao, P. J., Bott, A. F.A., Burger, S., Chen, H., Cruz, F. D., Davenne, T., Efthymiopoulos, I., Froula, D. H., Goillot, A., Gudmundsson, Jon Tomas, Haberberger, D., Halliday, J. W.D., Hodge, T., Huffman, B. T., Iaquinta, S., Miniati, F., Reville, B., Sarkar, S., Schekochihin, A. A., Silva, L. O., Simpson, R., Stergiou, V., Trines, R. M.G.M., Vieu, T., Charitonidis, N., Bingham, R., Gregori, G., Arrowsmith, C. D., Simon, P., Bilbao, P. J., Bott, A. F.A., Burger, S., Chen, H., Cruz, F. D., Davenne, T., Efthymiopoulos, I., Froula, D. H., Goillot, A., Gudmundsson, Jon Tomas, Haberberger, D., Halliday, J. W.D., Hodge, T., Huffman, B. T., Iaquinta, S., Miniati, F., Reville, B., Sarkar, S., Schekochihin, A. A., Silva, L. O., Simpson, R., Stergiou, V., Trines, R. M.G.M., Vieu, T., Charitonidis, N., Bingham, R., and Gregori, G.
Abstract: Relativistic electron-positron plasmas are ubiquitous in extreme astrophysical environments such as black-hole and neutron-star magnetospheres, where accretion-powered jets and pulsar winds are expected to be enriched with electron-positron pairs. Their role in the dynamics of such environments is in many cases believed to be fundamental, but their behavior differs significantly from typical electron-ion plasmas due to the matter-antimatter symmetry of the charged components. So far, our experimental inability to produce large yields of positrons in quasi-neutral beams has restricted the understanding of electron-positron pair plasmas to simple numerical and analytical studies, which are rather limited. We present the first experimental results confirming the generation of high-density, quasi-neutral, relativistic electron-positron pair beams using the 440 GeV/c beam at CERN’s Super Proton Synchrotron (SPS) accelerator. Monte Carlo simulations agree well with the experimental data and show that the characteristic scales necessary for collective plasma behavior, such as the Debye length and the collisionless skin depth, are exceeded by the measured size of the produced pair beams. Our work opens up the possibility of directly probing the microphysics of pair plasmas beyond quasi-linear evolution into regimes that are challenging to simulate or measure via astronomical observations., QC 20240701
Published: 2024
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11. Design, Synthesis, and Evaluation of New 1H-Benzo[d]imidazole Based PqsR Inhibitors as Adjuvant Therapy for Pseudomonas aeruginosa Infections

Author: Soukarieh, Fadi, Mashabi, Alaa, Richardson, William, Oton, Eduard Vico, Romero, Manuel, Dubern, Jean-Frederic, Robertson, Shaun N., Lucanto, Simone, Markham-Lee, Zoe, Sou, Tomás, Kukavica-Ibrulj, Irena, Levesque, Roger C., Bergström, Christel, Halliday, Nigel, Kellam, Barrie, Emsley, Jonas, Heeb, Stephan, Williams, Paul, Stocks, Michael J., Camara, Miguel, Soukarieh, Fadi, Mashabi, Alaa, Richardson, William, Oton, Eduard Vico, Romero, Manuel, Dubern, Jean-Frederic, Robertson, Shaun N., Lucanto, Simone, Markham-Lee, Zoe, Sou, Tomás, Kukavica-Ibrulj, Irena, Levesque, Roger C., Bergström, Christel, Halliday, Nigel, Kellam, Barrie, Emsley, Jonas, Heeb, Stephan, Williams, Paul, Stocks, Michael J., and Camara, Miguel
Abstract: Pseudomonas aeruginosa is one of the top priority pathogens that requires immediate attention according to the World Health Organisation (WHO). Due to the alarming shortage of novel antimicrobials, targeting quorum sensing (QS), a bacterial cell to cell signaling system controlling virulence, has emerged as a promising approach as an antibiotic adjuvant therapy. Interference with the pqs system, one of three QS systems in P. aeruginosa, results in reduction of bacterial virulence gene expression and biofilm maturation. Herein, we report a hit to lead process to fine-tune the potency of our previously reported inhibitor 1 (IC50 3.2 mu M in P. aeruginosa PAO1-L), which led to the discovery of 2-(4-(3-((6-chloro-1-isopropyl-1H-benzo[d]imidazol-2-yl)amino)-2-hydroxypropoxy)phenyl)acetonitrile (6f) as a potent PqsR antagonist. Compound 6f inhibited the PqsR-controlled P-pqsA-lux transcriptional reporter fusion in P. aeruginosa at low submicromolar concentrations. Moreover, 6f showed improved efficacy against P. aeruginosa CF isolates with significant inhibition of pyocyanin, 2-alkyl-4(1H)-quinolones production.
Published: 2024
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12. Knee braces for knee osteoarthritis: A scoping review and narrative synthesis of interventions in randomised controlled trials

Author: Holden, M A, Murphy, M, Simkins, J, Thomas, M J, Huckfield, L, Quicke, J G, Halliday, N, Birrell, F N, Borrelli, B, Callaghan, MJ, Dziedzic, K, Felson, D, Foster, N E, Ingram, C, Jinks, C, Jowett, S, Nicholls, E, Peat, G, Holden, M A, Murphy, M, Simkins, J, Thomas, M J, Huckfield, L, Quicke, J G, Halliday, N, Birrell, F N, Borrelli, B, Callaghan, MJ, Dziedzic, K, Felson, D, Foster, N E, Ingram, C, Jinks, C, Jowett, S, Nicholls, E, and Peat, G
Abstract: To identify and synthesise the content of knee bracing interventions in randomised controlled trials (RCTs) of knee osteoarthritis (OA). In this scoping review, three electronic databases (PubMed, Web of Science, Cochrane) were searched up to 10th June 2024. Nineteen previous systematic reviews of knee bracing for knee OA and four recent international clinical practice guidelines were also hand searched. Identified studies were screened for eligibility by two independent reviewers. Information on bracing interventions was extracted from included RCT reports, informed by Template for Intervention Description and Replication (TIDieR) guidelines. Data were synthesised narratively. Thirty-one RCTs testing 47 different bracing interventions were included. Braces were broadly grouped as valgus/varus, patellofemoral, sleeve, neutral hinged, or control/placebo knee braces. Brace manufacturer and models varied, as did amount of recommended brace use. Only three interventions specifically targeted brace adherence. Information on brace providers, setting, number of treatment sessions, and intervention modification over time was poorly reported. Adherence to brace use was described for 32 (68%) interventions, most commonly via self-report. Several mechanisms of action for knee braces were proposed, broadly grouped as biomechanical, neuromuscular, and psychological. Many different knee brace interventions have been tested for knee OA, with several proposed mechanisms of action, a lack of focus on adherence, and a lack of full reporting. These issues may be contributing to the heterogeneous findings and inconsistent guideline recommendations about the clinical effectiveness of knee bracing for knee OA to date.
Published: 2024

13. Design, Synthesis, and Evaluation of New 1H-Benzo[d]imidazole Based PqsR Inhibitors as Adjuvant Therapy for Pseudomonas aeruginosa Infections

Author: Soukarieh, Fadi, Mashabi, Alaa, Richardson, William, Oton, Eduard Vico, Romero, Manuel, Dubern, Jean-Frederic, Robertson, Shaun N., Lucanto, Simone, Markham-Lee, Zoe, Sou, Tomás, Kukavica-Ibrulj, Irena, Levesque, Roger C., Bergström, Christel, Halliday, Nigel, Kellam, Barrie, Emsley, Jonas, Heeb, Stephan, Williams, Paul, Stocks, Michael J., Camara, Miguel, Soukarieh, Fadi, Mashabi, Alaa, Richardson, William, Oton, Eduard Vico, Romero, Manuel, Dubern, Jean-Frederic, Robertson, Shaun N., Lucanto, Simone, Markham-Lee, Zoe, Sou, Tomás, Kukavica-Ibrulj, Irena, Levesque, Roger C., Bergström, Christel, Halliday, Nigel, Kellam, Barrie, Emsley, Jonas, Heeb, Stephan, Williams, Paul, Stocks, Michael J., and Camara, Miguel
Abstract: Pseudomonas aeruginosa is one of the top priority pathogens that requires immediate attention according to the World Health Organisation (WHO). Due to the alarming shortage of novel antimicrobials, targeting quorum sensing (QS), a bacterial cell to cell signaling system controlling virulence, has emerged as a promising approach as an antibiotic adjuvant therapy. Interference with the pqs system, one of three QS systems in P. aeruginosa, results in reduction of bacterial virulence gene expression and biofilm maturation. Herein, we report a hit to lead process to fine-tune the potency of our previously reported inhibitor 1 (IC50 3.2 mu M in P. aeruginosa PAO1-L), which led to the discovery of 2-(4-(3-((6-chloro-1-isopropyl-1H-benzo[d]imidazol-2-yl)amino)-2-hydroxypropoxy)phenyl)acetonitrile (6f) as a potent PqsR antagonist. Compound 6f inhibited the PqsR-controlled P-pqsA-lux transcriptional reporter fusion in P. aeruginosa at low submicromolar concentrations. Moreover, 6f showed improved efficacy against P. aeruginosa CF isolates with significant inhibition of pyocyanin, 2-alkyl-4(1H)-quinolones production.
Published: 2024
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14. Obstetric anaesthesia and socio-economic disparity

Author: Halliday, Lucy Olivia Egan and Halliday, Lucy Olivia Egan
Published: 2024

15. Justice and Housing

Author: Halliday, D, Meyer, M, Halliday, D, and Meyer, M
Abstract: This article surveys various topics that link questions about housing with considerations of economic justice. Housing has received increasing attention from philosophers within the last decade. In political philosophy, some aspects of a topic attract more attention than others. Presently, philosophical reflection focuses on the value of a home; homelessness; gentrification; segregation; and spatial justice, with a substantial body of literature developing on these interconnected themes. We highlight some of the recent contributions to the field of housing justice while also identifying areas that have received less attention. Specifically, we emphasize the importance of further philosophical exploration into how macroeconomic factors, like fiscal and monetary policy, impact housing justice. Additionally, we advocate for normative approaches that underscore justice issues not readily addressed by frameworks prioritizing human flourishing or relational equality.
Published: 2024

16. Treatment-resistant tinea caused by Trichophyton indotineae in Australia

Author: Chua, KYL, Halliday, CL, Chen, SC-A, Koning, S, Pawlikowski, J, du Cros, P, Korman, TM, Chua, KYL, Halliday, CL, Chen, SC-A, Koning, S, Pawlikowski, J, du Cros, P, and Korman, TM
Published: 2024

17. Population Aging and the Retirement Age

Author: Halliday, D and Halliday, D
Abstract: Numerous jurisdictions have recently raised the age of retirement or plan to do so. Pressure to extend people's working lives is due to population aging, which makes it harder to fund retirement through existing methods. Raising the retirement age can improve the ‘dependency ratio’ by increasing the fraction of the population that works (and pays taxes) relative to the fraction retired. This article gives sustained attention to connecting the case for retirement with one view about wellbeing, according to which old age is subject to distinctive goods. The importance of being able to access these goods in old age favours an eventual exit from labour market participation that retirement provisions enable. This view is stronger than one that treats retirement as merely a safety net to enable people to stop work only when advanced aging makes it unreasonably burdensome. At the same time, the view likely does not justify status quo retirement ages, meaning that some increase to the retirement age might be defensible. The article also seeks to illuminate ways in which different aspects of population aging – in particular the distinction between dependency ratios and inequalities in longevity – bear differently on the wider debate about justice and retirement.
Published: 2024

18. Design, Synthesis, and Evaluation of New 1H-Benzo[d]imidazole Based PqsR Inhibitors as Adjuvant Therapy for Pseudomonas aeruginosa Infections

Author: Soukarieh, Fadi, Mashabi, Alaa, Richardson, William, Oton, Eduard Vico, Romero, Manuel, Dubern, Jean-Frederic, Robertson, Shaun N., Lucanto, Simone, Markham-Lee, Zoe, Sou, Tomás, Kukavica-Ibrulj, Irena, Levesque, Roger C., Bergström, Christel, Halliday, Nigel, Kellam, Barrie, Emsley, Jonas, Heeb, Stephan, Williams, Paul, Stocks, Michael J., Camara, Miguel, Soukarieh, Fadi, Mashabi, Alaa, Richardson, William, Oton, Eduard Vico, Romero, Manuel, Dubern, Jean-Frederic, Robertson, Shaun N., Lucanto, Simone, Markham-Lee, Zoe, Sou, Tomás, Kukavica-Ibrulj, Irena, Levesque, Roger C., Bergström, Christel, Halliday, Nigel, Kellam, Barrie, Emsley, Jonas, Heeb, Stephan, Williams, Paul, Stocks, Michael J., and Camara, Miguel
Abstract: Pseudomonas aeruginosa is one of the top priority pathogens that requires immediate attention according to the World Health Organisation (WHO). Due to the alarming shortage of novel antimicrobials, targeting quorum sensing (QS), a bacterial cell to cell signaling system controlling virulence, has emerged as a promising approach as an antibiotic adjuvant therapy. Interference with the pqs system, one of three QS systems in P. aeruginosa, results in reduction of bacterial virulence gene expression and biofilm maturation. Herein, we report a hit to lead process to fine-tune the potency of our previously reported inhibitor 1 (IC50 3.2 mu M in P. aeruginosa PAO1-L), which led to the discovery of 2-(4-(3-((6-chloro-1-isopropyl-1H-benzo[d]imidazol-2-yl)amino)-2-hydroxypropoxy)phenyl)acetonitrile (6f) as a potent PqsR antagonist. Compound 6f inhibited the PqsR-controlled P-pqsA-lux transcriptional reporter fusion in P. aeruginosa at low submicromolar concentrations. Moreover, 6f showed improved efficacy against P. aeruginosa CF isolates with significant inhibition of pyocyanin, 2-alkyl-4(1H)-quinolones production.
Published: 2024
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19. A ubiquitous spectrolaminar motif of local field potential power across the primate cortex

Author: Mendoza-Halliday, Diego, Major, Alex James, Lee, Noah, Lichtenfeld, Maxwell J, Carlson, Brock, Mitchell, Blake, Meng, Patrick D, Xiong, Yihan Sophy, Westerberg, Jacob A, Jia, Xiaoxuan, Johnston, Kevin D, Selvanayagam, Janahan, Everling, Stefan, Maier, Alexander, Desimone, Robert, Miller, Earl K, Bastos, André M, Mendoza-Halliday, Diego, Major, Alex James, Lee, Noah, Lichtenfeld, Maxwell J, Carlson, Brock, Mitchell, Blake, Meng, Patrick D, Xiong, Yihan Sophy, Westerberg, Jacob A, Jia, Xiaoxuan, Johnston, Kevin D, Selvanayagam, Janahan, Everling, Stefan, Maier, Alexander, Desimone, Robert, Miller, Earl K, and Bastos, André M
Abstract: The mammalian cerebral cortex is anatomically organized into a six-layer motif. It is currently unknown whether a corresponding laminar motif of neuronal activity patterns exists across the cortex. Here we report such a motif in the power of local field potentials (LFPs). Using laminar probes, we recorded LFPs from 14 cortical areas across the cortical hierarchy in five macaque monkeys. The laminar locations of recordings were histologically identified by electrolytic lesions. Across all areas, we found a ubiquitous spectrolaminar pattern characterized by an increasing deep-to-superficial layer gradient of high-frequency power peaking in layers 2/3 and an increasing superficial-to-deep gradient of alpha-beta power peaking in layers 5/6. Laminar recordings from additional species showed that the spectrolaminar pattern is highly preserved among primates-macaque, marmoset and human-but more dissimilar in mouse. Our results suggest the existence of a canonical layer-based and frequency-based mechanism for cortical computation.
Published: 2024

20. Predicting neurodegeneration from sleep related biofluid changes

Author: Yang, Yue, Kim, Woojin S., Michaelian, Johannes C., Lewis, Simon J. G., Phillips, Craig L., D'Rozario, Angela L., Chatterjee, Pratishtha, Martins, Ralph N., Grunstein, Ron, Halliday, Glenda M., Naismith, Sharon L., Yang, Yue, Kim, Woojin S., Michaelian, Johannes C., Lewis, Simon J. G., Phillips, Craig L., D'Rozario, Angela L., Chatterjee, Pratishtha, Martins, Ralph N., Grunstein, Ron, Halliday, Glenda M., and Naismith, Sharon L.
Abstract: Sleep-wake disturbances are common in neurodegenerative diseases and may occur years before the clinical diagnosis, potentially either representing an early stage of the disease itself or acting as a pathophysiological driver. Therefore, discovering biomarkers that identify individuals with sleep-wake disturbances who are at risk of developing neurodegenerative diseases will allow early diagnosis and intervention. Given the association between sleep and neurodegeneration, the most frequently analyzed fluid biomarkers in people with sleep-wake disturbances to date include those directly associated with neurodegeneration itself, such as neurofilament light chain, phosphorylated tau, amyloid-beta and alpha-synuclein. Abnormalities in these biomarkers in patients with sleep-wake disturbances are considered as evidence of an underlying neurodegenerative process. Levels of hormonal sleep-related biomarkers such as melatonin, cortisol and orexin are often abnormal in patients with clinical neurodegenerative diseases, but their relationships with the more standard neurodegenerative biomarkers remain unclear. Similarly, it is unclear whether other chronobiological/circadian biomarkers, such as disrupted clock gene expression, are causal factors or a consequence of neurodegeneration. Current data would suggest that a combination of fluid biomarkers may identify sleep-wake disturbances that are most predictive for the risk of developing neurodegenerative disease with more optimal sensitivity and specificity.
Published: 2024

21. Priority effects transcend scales and disciplines in biology

Author: Stroud, J.T., Delory, B.M., Barnes, E.M., Chase, J.M., De Meester, L., Dieskau, J., Grainger, T.N., Halliday, F.W., Kardol, P., Knight, Tiffany, Ladouceur, Emma, Little, C.J., Roscher, Christiane, Sarneel, J.M., Temperton, V.M., van Steijn, T.L.H., Werner, C.M., Wood, C.W., Fukami, T., Stroud, J.T., Delory, B.M., Barnes, E.M., Chase, J.M., De Meester, L., Dieskau, J., Grainger, T.N., Halliday, F.W., Kardol, P., Knight, Tiffany, Ladouceur, Emma, Little, C.J., Roscher, Christiane, Sarneel, J.M., Temperton, V.M., van Steijn, T.L.H., Werner, C.M., Wood, C.W., and Fukami, T.
Abstract: Although primarily studied through the lens of community ecology, phenomena consistent with priority effects appear to be widespread across many different scenarios spanning a broad range of spatial, temporal, and biological scales. However, communication between these research fields is inconsistent and has resulted in a fragmented co-citation landscape, likely due to the diversity of terms used to refer to priority effects across these fields. We review these related terms, and the biological contexts in which they are used, to facilitate greater cross-disciplinary cohesion in research on priority effects. In breaking down these semantic barriers, we aim to provide a framework to better understand the conditions and mechanisms of priority effects, and their consequences across spatial and temporal scales.
Published: 2024

22. Inconsistencies within the proposed framework for stabilizing fungal nomenclature risk further confusion

Author: Kidd, Sarah E, Hagen, Ferry, Halliday, Catriona L, Abdolrasouli, Alireza, Boekhout, Teun, Crous, Pedro W, Ellis, David H, Elvy, Juliet, Forrest, Graeme N, Groenewald, Marizeth, Hahn, Rosane C, Houbraken, Jos, Rodrigues, Anderson M, Scott, James, Sorrell, Tania C, Summerbell, Richard C, Tsui, Clement K M, Yurkov, Andrey, Chen, Sharon C-A, Kidd, Sarah E, Hagen, Ferry, Halliday, Catriona L, Abdolrasouli, Alireza, Boekhout, Teun, Crous, Pedro W, Ellis, David H, Elvy, Juliet, Forrest, Graeme N, Groenewald, Marizeth, Hahn, Rosane C, Houbraken, Jos, Rodrigues, Anderson M, Scott, James, Sorrell, Tania C, Summerbell, Richard C, Tsui, Clement K M, Yurkov, Andrey, and Chen, Sharon C-A
Published: 2024

23. Structure and Dynamics of Magneto-Inertial, Differentially Rotating Laboratory Plasmas

Author: Valenzuela-Villaseca, V., Suttle, L. G., Suzuki-Vidal, F., Halliday, J. W. D., Russell, D. R., Merlini, S., Tubman, E. R., Hare, J. D., Chittenden, J. P., Koepke, M. E., Blackman, E. G., Lebedev, S. V., Valenzuela-Villaseca, V., Suttle, L. G., Suzuki-Vidal, F., Halliday, J. W. D., Russell, D. R., Merlini, S., Tubman, E. R., Hare, J. D., Chittenden, J. P., Koepke, M. E., Blackman, E. G., and Lebedev, S. V.
Abstract: We present a detailed characterization of the structure and evolution of differentially rotating plasmas driven on the MAGPIE pulsed-power generator (1.4 MA peak current, 240 ns rise-time). The experiments were designed to simulate physics relevant to accretion discs and jets on laboratory scales. A cylindrical aluminium wire array Z pinch enclosed by return posts with an overall azimuthal off-set angle was driven to produce ablation plasma flows that propagate inwards in a slightly off-radial trajectory, injecting mass, angular momentum, and confining ram pressure to a rotating plasma column on the axis. However, the plasma is free to expand axially, forming a collimated, differentially rotating axial jet that propagates at $\approx 100$ km/s. The density profile of the jet corresponds to a dense shell surrounding a low-density core, which is consistent with the centrifugal barrier effect being sustained along the jet's propagation. We show analytically that, as the rotating plasma accretes mass, conservation of mass and momentum implies plasma radial growth scaling as $r \propto t^{1/3}$. As the characteristic moment of inertia increases, the rotation velocity is predicted to decrease and settle on a characteristic value $\approx 20$ km/s. We find that both predictions are in agreement with Thomson scattering and optical self-emission imaging measurements., Comment: Submitted to the Journal of Plasma Physics. 22 pages, 9 figures
Published: 2024

24. Observation of Seven Astrophysical Tau Neutrino Candidates with IceCube

Author: IceCube Collaboration, Abbasi, R., Ackermann, M., Adams, J., Agarwalla, S. K., Aguilar, J. A., Ahlers, M., Alameddine, J. M., Amin, N. M., Andeen, K., Anton, G., Argüelles, C., Ashida, Y., Athanasiadou, S., Axani, S. N., Bai, X., V., A. Balagopal, Baricevic, M., Barwick, S. W., Basu, V., Bay, R., Beatty, J. J., Tjus, J. Becker, Beise, J., Bellenghi, C., Benning, C., BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Blaufuss, E., Blot, S., Bontempo, F., Book, J. Y., Meneguolo, C. Boscolo, Böser, S., Botner, O., Böttcher, J., Bourbeau, E., Braun, J., Brinson, B., Brostean-Kaiser, J., Burley, R. T., Busse, R. S., Butterfield, D., Campana, M. A., Carloni, K., Carnie-Bronca, E. G., Chattopadhyay, S., Chau, N., Chen, C., Chen, Z., Chirkin, D., Choi, S., Clark, B. A., Classen, L., Coleman, A., Collin, G. H., Connolly, A., Conrad, J. M., Coppin, P., Correa, P., Cowen, D. F., Dave, P., De Clercq, C., DeLaunay, J. J., Delgado, D., Deng, S., Deoskar, K., Desai, A., Desiati, P., de Vries, K. D., de Wasseige, G., DeYoung, T., Diaz, A., Díaz-Vélez, J. C., Dittmer, M., Domi, A., Dujmovic, H., DuVernois, M. A., Ehrhardt, T., Eller, P., Ellinger, E., Mentawi, S. El, Elsässer, D., Engel, R., Erpenbeck, H., Evans, J., Evenson, P. A., Fan, K. L., Fang, K., Farrag, K., Fazely, A. R., Feigl, N., Fiedlschuster, S., Fienberg, A. T., Fischer, L., Fox, D., Franckowiak, A., Fritz, A., Fürst, P., Gallagher, J., Ganster, E., Garcia, A., Gerhardt, L., Ghadimi, A., Glaser, C., Glauch, T., Glüsenkamp, T., Goehlke, N., Gonzalez, J. G., Goswami, S., Grant, D., Gray, S. J., Gries, O., Griffin, S., Griswold, S., Groth, K. M., Günther, C., Gutjahr, P., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Hamdaoui, H., Minh, M. Ha, Hanson, K., Hardin, J., Harnisch, A. A., Hatch, P., Haungs, A., Helbing, K., Hellrung, J., Henningsen, F., Heuermann, L., Heyer, N., Hickford, S., Hidvegi, A., Hill, C., Hill, G. C., Hoffman, K. D., Hori, S., Hoshina, K., Hou, W., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., Hymon, K., In, S., Ishihara, A., Jacquart, M., Janik, O., Jansson, M., Japaridze, G. S., Jeong, M., Jin, M., Jones, B. J. P., Kang, D., Kang, W., Kang, X., Kappes, A., Kappesser, D., Kardum, L., Karg, T., Karl, M., Karle, A., Katz, U., Kauer, M., Kelley, J. L., Zathul, A. Khatee, Kheirandish, A., Kiryluk, J., Klein, S. R., Kochocki, A., Koirala, R., Kolanoski, H., Kontrimas, T., Köpke, L., Kopper, C., Koskinen, D. J., Koundal, P., Kovacevich, M., Kowalski, M., Kozynets, T., Krishnamoorthi, J., Kruiswijk, K., Krupczak, E., Kumar, A., Kun, E., Kurahashi, N., Lad, N., Gualda, C. Lagunas, Lamoureux, M., Larson, M. J., Latseva, S., Lauber, F., Lazar, J. P., Lee, J. W., DeHolton, K. Leonard, Leszczyńska, A., Lincetto, M., Liu, Q. R., Liubarska, M., Lohfink, E., Love, C., Mariscal, C. J. Lozano, Lucarelli, F., Luszczak, W., Lyu, Y., Madsen, J., Mahn, K. B. M., Makino, Y., Manao, E., Mancina, S., Sainte, W. Marie, Mariş, I. C., Marka, S., Marka, Z., Marsee, M., Martinez-Soler, I., Maruyama, R., Mayhew, F., McElroy, T., McNally, F., Mead, J. V., Meagher, K., Mechbal, S., Medina, A., Meier, M., Merckx, Y., Merten, L., Micallef, J., Mitchell, J., Montaruli, T., Moore, R. W., Morii, Y., Morse, R., Moulai, M., Mukherjee, T., Naab, R., Nagai, R., Nakos, M., Naumann, U., Necker, J., Negi, A., Neumann, M., Niederhausen, H., Nisa, M. U., Noell, A., Novikov, A., Nowicki, S. C., Pollmann, A. Obertacke, O'Dell, V., Oehler, M., Oeyen, B., Olivas, A., Orsoe, R., Osborn, J., O'Sullivan, E., Pandya, H., Pankova, D. V., Park, N., Parker, G. K., Paudel, E. N., Paul, L., Heros, C. Pérez de los, Peterson, J., Philippen, S., Pizzuto, A., Plum, M., Pontén, A., Popovych, Y., Rodriguez, M. Prado, Pries, B., Procter-Murphy, R., Przybylski, G. T., Raab, C., Rack-Helleis, J., Rawlins, K., Rechav, Z., Rehman, A., Reichherzer, P., Renzi, G., Resconi, E., Reusch, S., Rhode, W., Riedel, B., Rifaie, A., Roberts, E. J., Robertson, S., Rodan, S., Roellinghoff, G., Rongen, M., Rott, C., Ruhe, T., Ruohan, L., Ryckbosch, D., Safa, I., Saffer, J., Salazar-Gallegos, D., Sampathkumar, P., Herrera, S. E. Sanchez, Sandrock, A., Santander, M., Sarkar, S., Savelberg, J., Savina, P., Schaufel, M., Schieler, H., Schindler, S., Schlickmann, L., Schlüter, B., Schlüter, F., Schmeisser, N., Schmidt, T., Schneider, J., Schröder, F. G., Schumacher, L., Schwefer, G., Sclafani, S., Seckel, D., Seikh, M., Seunarine, S., Shah, R., Sharma, A., Shefali, S., Shimizu, N., Silva, M., Skrzypek, B., Smithers, B., Snihur, R., Soedingrekso, J., Søgaard, A., Soldin, D., Soldin, P., Sommani, G., Spannfellner, C., Spiczak, G. M., Stamatikos, M., Stanev, T., Stezelberger, T., Stürwald, T., Stuttard, T., Sullivan, G. W., Taboada, I., Ter-Antonyan, S., Thiesmeyer, M., Thompson, W. G., Thwaites, J., Tilav, S., Tollefson, K., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Tung, C. F., Turcotte, R., Twagirayezu, J. P., Ty, B., Elorrieta, M. A. Unland, Upadhyay, A. K., Upshaw, K., Valtonen-Mattila, N., Vandenbroucke, J., van Eijndhoven, N., Vannerom, D., van Santen, J., Vara, J., Veitch-Michaelis, J., Venugopal, M., Vereecken, M., Verpoest, S., Veske, D., Vijai, A., Walck, C., Weaver, C., Weigel, P., Weindl, A., Weldert, J., Wen, A. Y., Wendt, C., Werthebach, J., Weyrauch, M., Whitehorn, N., Wiebusch, C. H., Willey, N., Williams, D. R., Witthaus, L., Wolf, A., Wolf, M., Wrede, G., Xu, X. W., Yanez, J. P., Yildizci, E., Yoshida, S., Young, R., Yu, F., Yu, S., Zhang, Z., Zhelnin, P., Zilberman, P., Zimmerman, M., IceCube Collaboration, Abbasi, R., Ackermann, M., Adams, J., Agarwalla, S. K., Aguilar, J. A., Ahlers, M., Alameddine, J. M., Amin, N. M., Andeen, K., Anton, G., Argüelles, C., Ashida, Y., Athanasiadou, S., Axani, S. N., Bai, X., V., A. Balagopal, Baricevic, M., Barwick, S. W., Basu, V., Bay, R., Beatty, J. J., Tjus, J. Becker, Beise, J., Bellenghi, C., Benning, C., BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Blaufuss, E., Blot, S., Bontempo, F., Book, J. Y., Meneguolo, C. Boscolo, Böser, S., Botner, O., Böttcher, J., Bourbeau, E., Braun, J., Brinson, B., Brostean-Kaiser, J., Burley, R. T., Busse, R. S., Butterfield, D., Campana, M. A., Carloni, K., Carnie-Bronca, E. G., Chattopadhyay, S., Chau, N., Chen, C., Chen, Z., Chirkin, D., Choi, S., Clark, B. A., Classen, L., Coleman, A., Collin, G. H., Connolly, A., Conrad, J. M., Coppin, P., Correa, P., Cowen, D. F., Dave, P., De Clercq, C., DeLaunay, J. J., Delgado, D., Deng, S., Deoskar, K., Desai, A., Desiati, P., de Vries, K. D., de Wasseige, G., DeYoung, T., Diaz, A., Díaz-Vélez, J. C., Dittmer, M., Domi, A., Dujmovic, H., DuVernois, M. A., Ehrhardt, T., Eller, P., Ellinger, E., Mentawi, S. El, Elsässer, D., Engel, R., Erpenbeck, H., Evans, J., Evenson, P. A., Fan, K. L., Fang, K., Farrag, K., Fazely, A. R., Feigl, N., Fiedlschuster, S., Fienberg, A. T., Fischer, L., Fox, D., Franckowiak, A., Fritz, A., Fürst, P., Gallagher, J., Ganster, E., Garcia, A., Gerhardt, L., Ghadimi, A., Glaser, C., Glauch, T., Glüsenkamp, T., Goehlke, N., Gonzalez, J. G., Goswami, S., Grant, D., Gray, S. J., Gries, O., Griffin, S., Griswold, S., Groth, K. M., Günther, C., Gutjahr, P., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Hamdaoui, H., Minh, M. Ha, Hanson, K., Hardin, J., Harnisch, A. A., Hatch, P., Haungs, A., Helbing, K., Hellrung, J., Henningsen, F., Heuermann, L., Heyer, N., Hickford, S., Hidvegi, A., Hill, C., Hill, G. C., Hoffman, K. D., Hori, S., Hoshina, K., Hou, W., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., Hymon, K., In, S., Ishihara, A., Jacquart, M., Janik, O., Jansson, M., Japaridze, G. S., Jeong, M., Jin, M., Jones, B. J. P., Kang, D., Kang, W., Kang, X., Kappes, A., Kappesser, D., Kardum, L., Karg, T., Karl, M., Karle, A., Katz, U., Kauer, M., Kelley, J. L., Zathul, A. Khatee, Kheirandish, A., Kiryluk, J., Klein, S. R., Kochocki, A., Koirala, R., Kolanoski, H., Kontrimas, T., Köpke, L., Kopper, C., Koskinen, D. J., Koundal, P., Kovacevich, M., Kowalski, M., Kozynets, T., Krishnamoorthi, J., Kruiswijk, K., Krupczak, E., Kumar, A., Kun, E., Kurahashi, N., Lad, N., Gualda, C. Lagunas, Lamoureux, M., Larson, M. J., Latseva, S., Lauber, F., Lazar, J. P., Lee, J. W., DeHolton, K. Leonard, Leszczyńska, A., Lincetto, M., Liu, Q. R., Liubarska, M., Lohfink, E., Love, C., Mariscal, C. J. Lozano, Lucarelli, F., Luszczak, W., Lyu, Y., Madsen, J., Mahn, K. B. M., Makino, Y., Manao, E., Mancina, S., Sainte, W. Marie, Mariş, I. C., Marka, S., Marka, Z., Marsee, M., Martinez-Soler, I., Maruyama, R., Mayhew, F., McElroy, T., McNally, F., Mead, J. V., Meagher, K., Mechbal, S., Medina, A., Meier, M., Merckx, Y., Merten, L., Micallef, J., Mitchell, J., Montaruli, T., Moore, R. W., Morii, Y., Morse, R., Moulai, M., Mukherjee, T., Naab, R., Nagai, R., Nakos, M., Naumann, U., Necker, J., Negi, A., Neumann, M., Niederhausen, H., Nisa, M. U., Noell, A., Novikov, A., Nowicki, S. C., Pollmann, A. Obertacke, O'Dell, V., Oehler, M., Oeyen, B., Olivas, A., Orsoe, R., Osborn, J., O'Sullivan, E., Pandya, H., Pankova, D. V., Park, N., Parker, G. K., Paudel, E. N., Paul, L., Heros, C. Pérez de los, Peterson, J., Philippen, S., Pizzuto, A., Plum, M., Pontén, A., Popovych, Y., Rodriguez, M. Prado, Pries, B., Procter-Murphy, R., Przybylski, G. T., Raab, C., Rack-Helleis, J., Rawlins, K., Rechav, Z., Rehman, A., Reichherzer, P., Renzi, G., Resconi, E., Reusch, S., Rhode, W., Riedel, B., Rifaie, A., Roberts, E. J., Robertson, S., Rodan, S., Roellinghoff, G., Rongen, M., Rott, C., Ruhe, T., Ruohan, L., Ryckbosch, D., Safa, I., Saffer, J., Salazar-Gallegos, D., Sampathkumar, P., Herrera, S. E. Sanchez, Sandrock, A., Santander, M., Sarkar, S., Savelberg, J., Savina, P., Schaufel, M., Schieler, H., Schindler, S., Schlickmann, L., Schlüter, B., Schlüter, F., Schmeisser, N., Schmidt, T., Schneider, J., Schröder, F. G., Schumacher, L., Schwefer, G., Sclafani, S., Seckel, D., Seikh, M., Seunarine, S., Shah, R., Sharma, A., Shefali, S., Shimizu, N., Silva, M., Skrzypek, B., Smithers, B., Snihur, R., Soedingrekso, J., Søgaard, A., Soldin, D., Soldin, P., Sommani, G., Spannfellner, C., Spiczak, G. M., Stamatikos, M., Stanev, T., Stezelberger, T., Stürwald, T., Stuttard, T., Sullivan, G. W., Taboada, I., Ter-Antonyan, S., Thiesmeyer, M., Thompson, W. G., Thwaites, J., Tilav, S., Tollefson, K., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Tung, C. F., Turcotte, R., Twagirayezu, J. P., Ty, B., Elorrieta, M. A. Unland, Upadhyay, A. K., Upshaw, K., Valtonen-Mattila, N., Vandenbroucke, J., van Eijndhoven, N., Vannerom, D., van Santen, J., Vara, J., Veitch-Michaelis, J., Venugopal, M., Vereecken, M., Verpoest, S., Veske, D., Vijai, A., Walck, C., Weaver, C., Weigel, P., Weindl, A., Weldert, J., Wen, A. Y., Wendt, C., Werthebach, J., Weyrauch, M., Whitehorn, N., Wiebusch, C. H., Willey, N., Williams, D. R., Witthaus, L., Wolf, A., Wolf, M., Wrede, G., Xu, X. W., Yanez, J. P., Yildizci, E., Yoshida, S., Young, R., Yu, F., Yu, S., Zhang, Z., Zhelnin, P., Zilberman, P., and Zimmerman, M.
Abstract: We report on a measurement of astrophysical tau neutrinos with 9.7 years of IceCube data. Using convolutional neural networks trained on images derived from simulated events, seven candidate $\nu_\tau$ events were found with visible energies ranging from roughly 20 TeV to 1 PeV and a median expected parent $\nu_\tau$ energy of about 200 TeV. Considering backgrounds from astrophysical and atmospheric neutrinos, and muons from $\pi^\pm/K^\pm$ decays in atmospheric air showers, we obtain a total estimated background of about 0.5 events, dominated by non-$\nu_\tau$ astrophysical neutrinos. Thus, we rule out the absence of astrophysical $\nu_\tau$ at the $5\sigma$ level. The measured astrophysical $\nu_\tau$ flux is consistent with expectations based on previously published IceCube astrophysical neutrino flux measurements and neutrino oscillations., Comment: Accepted for publication in Physical Review Letters. This version includes full author list metadata
Published: 2024

25. Improved modeling of in-ice particle showers for IceCube event reconstruction

Author: Abbasi, R., Ackermann, M., Adams, J., Agarwalla, S. K., Aguilar, J. A., Ahlers, M., Alameddine, J. M., Amin, N. M., Andeen, K., Anton, G., Argüelles, C., Ashida, Y., Athanasiadou, S., Ausborm, L., Axani, S. N., Bai, X., V., A. Balagopal, Baricevic, M., Barwick, S. W., Bash, S., Basu, V., Bay, R., Beatty, J. J., Tjus, J. Becker, Beise, J., Bellenghi, C., Benning, C., BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Blaufuss, E., Blot, S., Bontempo, F., Book, J. Y., Meneguolo, C. Boscolo, Böser, S., Botner, O., Böttcher, J., Braun, J., Brinson, B., Brostean-Kaiser, J., Brusa, L., Burley, R. T., Busse, R. S., Butterfield, D., Campana, M. A., Caracas, I., Carloni, K., Carpio, J., Chattopadhyay, S., Chau, N., Chen, Z., Chirkin, D., Choi, S., Clark, B. A., Coleman, A., Collin, G. H., Connolly, A., Conrad, J. M., Coppin, P., Corley, R., Correa, P., Cowen, D. F., Dave, P., De Clercq, C., DeLaunay, J. J., Delgado, D., Deng, S., Deoskar, K., Desai, A., Desiati, P., de Vries, K. D., de Wasseige, G., DeYoung, T., Diaz, A., Díaz-Vélez, J. C., Dittmer, M., Domi, A., Draper, L., Dujmovic, H., Dutta, K., DuVernois, M. A., Ehrhardt, T., Eidenschink, L., Eimer, A., Eller, P., Ellinger, E., Mentawi, S. El, Elsässer, D., Engel, R., Erpenbeck, H., Evans, J., Evenson, P. A., Fan, K. L., Fang, K., Farrag, K., Fazely, A. R., Fedynitch, A., Feigl, N., Fiedlschuster, S., Finley, C., Fischer, L., Fox, D., Franckowiak, A., Fürst, P., Gallagher, J., Ganster, E., Garcia, A., Genton, E., Gerhardt, L., Ghadimi, A., Girard-Carillo, C., Glaser, C., Glüsenkamp, T., Gonzalez, J. G., Goswami, S., Granados, A., Grant, D., Gray, S. J., Gries, O., Griffin, S., Griswold, S., Groth, K. M., Günther, C., Gutjahr, P., Ha, C., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Hamdaoui, H., Minh, M. Ha, Handt, M., Hanson, K., Hardin, J., Harnisch, A. A., Hatch, P., Haungs, A., Häußler, J., Helbing, K., Hellrung, J., Hermannsgabner, J., Heuermann, L., Heyer, N., Hickford, S., Hidvegi, A., Hill, C., Hill, G. C., Hoffman, K. D., Hori, S., Hoshina, K., Hostert, M., Hou, W., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., Hymon, K., Ishihara, A., Iwakiri, W., Jacquart, M., Janik, O., Jansson, M., Japaridze, G. S., Jeong, M., Jin, M., Jones, B. J. P., Kamp, N., Kang, D., Kang, W., Kang, X., Kappes, A., Kappesser, D., Kardum, L., Karg, T., Karl, M., Karle, A., Katil, A., Katz, U., Kauer, M., Kelley, J. L., Khanal, M., Zathul, A. Khatee, Kheirandish, A., Kiryluk, J., Klein, S. R., Kochocki, A., Koirala, R., Kolanoski, H., Kontrimas, T., Köpke, L., Kopper, C., Koskinen, D. J., Koundal, P., Kovacevich, M., Kowalski, M., Kozynets, T., Krishnamoorthi, J., Kruiswijk, K., Krupczak, E., Kumar, A., Kun, E., Kurahashi, N., Lad, N., Gualda, C. Lagunas, Lamoureux, M., Larson, M. J., Latseva, S., Lauber, F., Lazar, J. P., Lee, J. W., DeHolton, K. Leonard, Leszczyńska, A., Liao, J., Lincetto, M., Liubarska, M., Lohfink, E., Love, C., Mariscal, C. J. Lozano, Lu, L., Lucarelli, F., Luszczak, W., Lyu, Y., Madsen, J., Magnus, E., Mahn, K. B. M., Makino, Y., Manao, E., Mancina, S., Sainte, W. Marie, Mariş, I. C., Marka, S., Marka, Z., Marsee, M., Martinez-Soler, I., Maruyama, R., Mayhew, F., McElroy, T., McNally, F., Mead, J. V., Meagher, K., Mechbal, S., Medina, A., Meier, M., Merckx, Y., Merten, L., Micallef, J., Mitchell, J., Montaruli, T., Moore, R. W., Morii, Y., Morse, R., Moulai, M., Mukherjee, T., Naab, R., Nagai, R., Nakos, M., Naumann, U., Necker, J., Negi, A., Neumann, M., Niederhausen, H., Nisa, M. U., Noell, A., Novikov, A., Nowicki, S. C., Pollmann, A. Obertacke, O'Dell, V., Oeyen, B., Olivas, A., Orsoe, R., Osborn, J., O'Sullivan, E., Pandya, H., Park, N., Parker, G. K., Paudel, E. N., Paul, L., Heros, C. Pérez de los, Pernice, T., Peterson, J., Philippen, S., Pizzuto, A., Plum, M., Pontén, A., Popovych, Y., Rodriguez, M. Prado, Pries, B., Procter-Murphy, R., Przybylski, G. T., Raab, C., Rack-Helleis, J., Rawlins, K., Rechav, Z., Rehman, A., Reichherzer, P., Resconi, E., Reusch, S., Rhode, W., Riedel, B., Rifaie, A., Roberts, E. J., Robertson, S., Rodan, S., Roellinghoff, G., Rongen, M., Rosted, A., Rott, C., Ruhe, T., Ruohan, L., Ryckbosch, D., Safa, I., Saffer, J., Salazar-Gallegos, D., Sampathkumar, P., Sandrock, A., Santander, M., Sarkar, S., Savelberg, J., Savina, P., Schaile, P., Schaufel, M., Schieler, H., Schindler, S., Schlüter, B., Schlüter, F., Schmeisser, N., Schmidt, T., Schneider, J., Schröder, F. G., Schumacher, L., Sclafani, S., Seckel, D., Seikh, M., Seo, M., Seunarine, S., Myhr, P. Sevle, Shah, R., Shefali, S., Shimizu, N., Silva, M., Skrzypek, B., Smithers, B., Snihur, R., Soedingrekso, J., Søgaard, A., Soldin, D., Soldin, P., Sommani, G., Spannfellner, C., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stezelberger, T., Stürwald, T., Stuttard, T., Sullivan, G. W., Taboada, I., Ter-Antonyan, S., Terliuk, A., Thiesmeyer, M., Thompson, W. G., Thwaites, J., Tilav, S., Tollefson, K., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Turcotte, R., Twagirayezu, J. P., Elorrieta, M. A. Unland, Upadhyay, A. K., Upshaw, K., Vaidyanathan, A., Valtonen-Mattila, N., Vandenbroucke, J., van Eijndhoven, N., Vannerom, D., van Santen, J., Vara, J., Veitch-Michaelis, J., Venugopal, M., Vereecken, M., Verpoest, S., Veske, D., Vijai, A., Walck, C., Wang, A., Weaver, C., Weigel, P., Weindl, A., Weldert, J., Wen, A. Y., Wendt, C., Werthebach, J., Weyrauch, M., Whitehorn, N., Wiebusch, C. H., Williams, D. R., Witthaus, L., Wolf, A., Wolf, M., Wrede, G., Xu, X. W., Yanez, J. P., Yildizci, E., Yoshida, S., Young, R., Yu, S., Yuan, T., Zhang, Z., Zhelnin, P., Zilberman, P., Zimmerman, M., Abbasi, R., Ackermann, M., Adams, J., Agarwalla, S. K., Aguilar, J. A., Ahlers, M., Alameddine, J. M., Amin, N. M., Andeen, K., Anton, G., Argüelles, C., Ashida, Y., Athanasiadou, S., Ausborm, L., Axani, S. N., Bai, X., V., A. Balagopal, Baricevic, M., Barwick, S. W., Bash, S., Basu, V., Bay, R., Beatty, J. J., Tjus, J. Becker, Beise, J., Bellenghi, C., Benning, C., BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Blaufuss, E., Blot, S., Bontempo, F., Book, J. Y., Meneguolo, C. Boscolo, Böser, S., Botner, O., Böttcher, J., Braun, J., Brinson, B., Brostean-Kaiser, J., Brusa, L., Burley, R. T., Busse, R. S., Butterfield, D., Campana, M. A., Caracas, I., Carloni, K., Carpio, J., Chattopadhyay, S., Chau, N., Chen, Z., Chirkin, D., Choi, S., Clark, B. A., Coleman, A., Collin, G. H., Connolly, A., Conrad, J. M., Coppin, P., Corley, R., Correa, P., Cowen, D. F., Dave, P., De Clercq, C., DeLaunay, J. J., Delgado, D., Deng, S., Deoskar, K., Desai, A., Desiati, P., de Vries, K. D., de Wasseige, G., DeYoung, T., Diaz, A., Díaz-Vélez, J. C., Dittmer, M., Domi, A., Draper, L., Dujmovic, H., Dutta, K., DuVernois, M. A., Ehrhardt, T., Eidenschink, L., Eimer, A., Eller, P., Ellinger, E., Mentawi, S. El, Elsässer, D., Engel, R., Erpenbeck, H., Evans, J., Evenson, P. A., Fan, K. L., Fang, K., Farrag, K., Fazely, A. R., Fedynitch, A., Feigl, N., Fiedlschuster, S., Finley, C., Fischer, L., Fox, D., Franckowiak, A., Fürst, P., Gallagher, J., Ganster, E., Garcia, A., Genton, E., Gerhardt, L., Ghadimi, A., Girard-Carillo, C., Glaser, C., Glüsenkamp, T., Gonzalez, J. G., Goswami, S., Granados, A., Grant, D., Gray, S. J., Gries, O., Griffin, S., Griswold, S., Groth, K. M., Günther, C., Gutjahr, P., Ha, C., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Hamdaoui, H., Minh, M. Ha, Handt, M., Hanson, K., Hardin, J., Harnisch, A. A., Hatch, P., Haungs, A., Häußler, J., Helbing, K., Hellrung, J., Hermannsgabner, J., Heuermann, L., Heyer, N., Hickford, S., Hidvegi, A., Hill, C., Hill, G. C., Hoffman, K. D., Hori, S., Hoshina, K., Hostert, M., Hou, W., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., Hymon, K., Ishihara, A., Iwakiri, W., Jacquart, M., Janik, O., Jansson, M., Japaridze, G. S., Jeong, M., Jin, M., Jones, B. J. P., Kamp, N., Kang, D., Kang, W., Kang, X., Kappes, A., Kappesser, D., Kardum, L., Karg, T., Karl, M., Karle, A., Katil, A., Katz, U., Kauer, M., Kelley, J. L., Khanal, M., Zathul, A. Khatee, Kheirandish, A., Kiryluk, J., Klein, S. R., Kochocki, A., Koirala, R., Kolanoski, H., Kontrimas, T., Köpke, L., Kopper, C., Koskinen, D. J., Koundal, P., Kovacevich, M., Kowalski, M., Kozynets, T., Krishnamoorthi, J., Kruiswijk, K., Krupczak, E., Kumar, A., Kun, E., Kurahashi, N., Lad, N., Gualda, C. Lagunas, Lamoureux, M., Larson, M. J., Latseva, S., Lauber, F., Lazar, J. P., Lee, J. W., DeHolton, K. Leonard, Leszczyńska, A., Liao, J., Lincetto, M., Liubarska, M., Lohfink, E., Love, C., Mariscal, C. J. Lozano, Lu, L., Lucarelli, F., Luszczak, W., Lyu, Y., Madsen, J., Magnus, E., Mahn, K. B. M., Makino, Y., Manao, E., Mancina, S., Sainte, W. Marie, Mariş, I. C., Marka, S., Marka, Z., Marsee, M., Martinez-Soler, I., Maruyama, R., Mayhew, F., McElroy, T., McNally, F., Mead, J. V., Meagher, K., Mechbal, S., Medina, A., Meier, M., Merckx, Y., Merten, L., Micallef, J., Mitchell, J., Montaruli, T., Moore, R. W., Morii, Y., Morse, R., Moulai, M., Mukherjee, T., Naab, R., Nagai, R., Nakos, M., Naumann, U., Necker, J., Negi, A., Neumann, M., Niederhausen, H., Nisa, M. U., Noell, A., Novikov, A., Nowicki, S. C., Pollmann, A. Obertacke, O'Dell, V., Oeyen, B., Olivas, A., Orsoe, R., Osborn, J., O'Sullivan, E., Pandya, H., Park, N., Parker, G. K., Paudel, E. N., Paul, L., Heros, C. Pérez de los, Pernice, T., Peterson, J., Philippen, S., Pizzuto, A., Plum, M., Pontén, A., Popovych, Y., Rodriguez, M. Prado, Pries, B., Procter-Murphy, R., Przybylski, G. T., Raab, C., Rack-Helleis, J., Rawlins, K., Rechav, Z., Rehman, A., Reichherzer, P., Resconi, E., Reusch, S., Rhode, W., Riedel, B., Rifaie, A., Roberts, E. J., Robertson, S., Rodan, S., Roellinghoff, G., Rongen, M., Rosted, A., Rott, C., Ruhe, T., Ruohan, L., Ryckbosch, D., Safa, I., Saffer, J., Salazar-Gallegos, D., Sampathkumar, P., Sandrock, A., Santander, M., Sarkar, S., Savelberg, J., Savina, P., Schaile, P., Schaufel, M., Schieler, H., Schindler, S., Schlüter, B., Schlüter, F., Schmeisser, N., Schmidt, T., Schneider, J., Schröder, F. G., Schumacher, L., Sclafani, S., Seckel, D., Seikh, M., Seo, M., Seunarine, S., Myhr, P. Sevle, Shah, R., Shefali, S., Shimizu, N., Silva, M., Skrzypek, B., Smithers, B., Snihur, R., Soedingrekso, J., Søgaard, A., Soldin, D., Soldin, P., Sommani, G., Spannfellner, C., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stezelberger, T., Stürwald, T., Stuttard, T., Sullivan, G. W., Taboada, I., Ter-Antonyan, S., Terliuk, A., Thiesmeyer, M., Thompson, W. G., Thwaites, J., Tilav, S., Tollefson, K., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Turcotte, R., Twagirayezu, J. P., Elorrieta, M. A. Unland, Upadhyay, A. K., Upshaw, K., Vaidyanathan, A., Valtonen-Mattila, N., Vandenbroucke, J., van Eijndhoven, N., Vannerom, D., van Santen, J., Vara, J., Veitch-Michaelis, J., Venugopal, M., Vereecken, M., Verpoest, S., Veske, D., Vijai, A., Walck, C., Wang, A., Weaver, C., Weigel, P., Weindl, A., Weldert, J., Wen, A. Y., Wendt, C., Werthebach, J., Weyrauch, M., Whitehorn, N., Wiebusch, C. H., Williams, D. R., Witthaus, L., Wolf, A., Wolf, M., Wrede, G., Xu, X. W., Yanez, J. P., Yildizci, E., Yoshida, S., Young, R., Yu, S., Yuan, T., Zhang, Z., Zhelnin, P., Zilberman, P., and Zimmerman, M.
Abstract: The IceCube Neutrino Observatory relies on an array of photomultiplier tubes to detect Cherenkov light produced by charged particles in the South Pole ice. IceCube data analyses depend on an in-depth characterization of the glacial ice, and on novel approaches in event reconstruction that utilize fast approximations of photoelectron yields. Here, a more accurate model is derived for event reconstruction that better captures our current knowledge of ice optical properties. When evaluated on a Monte Carlo simulation set, the median angular resolution for in-ice particle showers improves by over a factor of three compared to a reconstruction based on a simplified model of the ice. The most substantial improvement is obtained when including effects of birefringence due to the polycrystalline structure of the ice. When evaluated on data classified as particle showers in the high-energy starting events sample, a significantly improved description of the events is observed., Comment: 28 pages, 18 figures, 1 table
Published: 2024

26. Characterization of the Astrophysical Diffuse Neutrino Flux using Starting Track Events in IceCube

Author: Abbasi, R., Ackermann, M., Adams, J., Agarwalla, S. K., Aguilar, J. A., Ahlers, M., Alameddine, J. M., Amin, N. M., Andeen, K., Anton, G., Argüelles, C., Ashida, Y., Athanasiadou, S., Ausborm, L., Axani, S. N., Bai, X., V., A. Balagopal, Baricevic, M., Barwick, S. W., Bash, S., Basu, V., Bay, R., Beatty, J. J., Tjus, J. Becker, Beise, J., Bellenghi, C., Benning, C., BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Blaufuss, E., Blot, S., Bontempo, F., Book, J. Y., Meneguolo, C. Boscolo, Böser, S., Botner, O., Böttcher, J., Braun, J., Brinson, B., Brostean-Kaiser, J., Brusa, L., Burley, R. T., Busse, R. S., Butterfield, D., Campana, M. A., Caracas, I., Carloni, K., Carpio, J., Chattopadhyay, S., Chau, N., Chen, Z., Chirkin, D., Choi, S., Clark, B. A., Coleman, A., Collin, G. H., Connolly, A., Conrad, J. M., Coppin, P., Corley, R., Correa, P., Cowen, D. F., Dave, P., De Clercq, C., DeLaunay, J. J., Delgado, D., Deng, S., Deoskar, K., Desai, A., Desiati, P., de Vries, K. D., de Wasseige, G., DeYoung, T., Diaz, A., Díaz-Vélez, J. C., Dittmer, M., Domi, A., Draper, L., Dujmovic, H., Dutta, K., DuVernois, M. A., Ehrhardt, T., Eidenschink, L., Eimer, A., Eller, P., Ellinger, E., Mentawi, S. El, Elsässer, D., Engel, R., Erpenbeck, H., Evans, J., Evenson, P. A., Fan, K. L., Fang, K., Farrag, K., Fazely, A. R., Fedynitch, A., Feigl, N., Fiedlschuster, S., Finley, C., Fischer, L., Fox, D., Franckowiak, A., Fürst, P., Gallagher, J., Ganster, E., Garcia, A., Genton, E., Gerhardt, L., Ghadimi, A., Girard-Carillo, C., Glaser, C., Glüsenkamp, T., Gonzalez, J. G., Goswami, S., Granados, A., Grant, D., Gray, S. J., Gries, O., Griffin, S., Griswold, S., Groth, K. M., Günther, C., Gutjahr, P., Ha, C., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Hamdaoui, H., Minh, M. Ha, Handt, M., Hanson, K., Hardin, J., Harnisch, A. A., Hatch, P., Haungs, A., Häußler, J., Helbing, K., Hellrung, J., Hermannsgabner, J., Heuermann, L., Heyer, N., Hickford, S., Hidvegi, A., Hill, C., Hill, G. C., Hoffman, K. D., Hori, S., Hoshina, K., Hostert, M., Hou, W., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., Hymon, K., Ishihara, A., Iwakiri, W., Jacquart, M., Janik, O., Jansson, M., Japaridze, G. S., Jeong, M., Jin, M., Jones, B. J. P., Kamp, N., Kang, D., Kang, W., Kang, X., Kappes, A., Kappesser, D., Kardum, L., Karg, T., Karl, M., Karle, A., Katil, A., Katz, U., Kauer, M., Kelley, J. L., Khanal, M., Zathul, A. Khatee, Kheirandish, A., Kiryluk, J., Klein, S. R., Kochocki, A., Koirala, R., Kolanoski, H., Kontrimas, T., Köpke, L., Kopper, C., Koskinen, D. J., Koundal, P., Kovacevich, M., Kowalski, M., Kozynets, T., Krishnamoorthi, J., Kruiswijk, K., Krupczak, E., Kumar, A., Kun, E., Kurahashi, N., Lad, N., Gualda, C. Lagunas, Lamoureux, M., Larson, M. J., Latseva, S., Lauber, F., Lazar, J. P., Lee, J. W., DeHolton, K. Leonard, Leszczyńska, A., Liao, J., Lincetto, M., Liubarska, M., Lohfink, E., Love, C., Mariscal, C. J. Lozano, Lu, L., Lucarelli, F., Luszczak, W., Lyu, Y., Madsen, J., Magnus, E., Mahn, K. B. M., Makino, Y., Manao, E., Mancina, S., Sainte, W. Marie, Mariş, I. C., Marka, S., Marka, Z., Marsee, M., Martinez-Soler, I., Maruyama, R., Mayhew, F., McElroy, T., McNally, F., Mead, J. V., Meagher, K., Mechbal, S., Medina, A., Meier, M., Merckx, Y., Merten, L., Micallef, J., Mitchell, J., Montaruli, T., Moore, R. W., Morii, Y., Morse, R., Moulai, M., Mukherjee, T., Naab, R., Nagai, R., Nakos, M., Naumann, U., Necker, J., Negi, A., Neumann, M., Niederhausen, H., Nisa, M. U., Noell, A., Novikov, A., Nowicki, S. C., Pollmann, A. Obertacke, O'Dell, V., Oeyen, B., Olivas, A., Orsoe, R., Osborn, J., O'Sullivan, E., Pandya, H., Park, N., Parker, G. K., Paudel, E. N., Paul, L., Heros, C. Pérez de los, Pernice, T., Peterson, J., Philippen, S., Pizzuto, A., Plum, M., Pontén, A., Popovych, Y., Rodriguez, M. Prado, Pries, B., Procter-Murphy, R., Przybylski, G. T., Raab, C., Rack-Helleis, J., Rawlins, K., Rechav, Z., Rehman, A., Reichherzer, P., Resconi, E., Reusch, S., Rhode, W., Riedel, B., Rifaie, A., Roberts, E. J., Robertson, S., Rodan, S., Roellinghoff, G., Rongen, M., Rosted, A., Rott, C., Ruhe, T., Ruohan, L., Ryckbosch, D., Safa, I., Saffer, J., Salazar-Gallegos, D., Sampathkumar, P., Sandrock, A., Santander, M., Sarkar, S., Savelberg, J., Savina, P., Schaile, P., Schaufel, M., Schieler, H., Schindler, S., Schlüter, B., Schlüter, F., Schmeisser, N., Schmidt, T., Schneider, J., Schröder, F. G., Schumacher, L., Sclafani, S., Seckel, D., Seikh, M., Seo, M., Seunarine, S., Myhr, P. Sevle, Shah, R., Shefali, S., Shimizu, N., Silva, M., Skrzypek, B., Smithers, B., Snihur, R., Soedingrekso, J., Søgaard, A., Soldin, D., Soldin, P., Sommani, G., Spannfellner, C., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stezelberger, T., Stürwald, T., Stuttard, T., Sullivan, G. W., Taboada, I., Ter-Antonyan, S., Terliuk, A., Thiesmeyer, M., Thompson, W. G., Thwaites, J., Tilav, S., Tollefson, K., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Turcotte, R., Twagirayezu, J. P., Elorrieta, M. A. Unland, Upadhyay, A. K., Upshaw, K., Vaidyanathan, A., Valtonen-Mattila, N., Vandenbroucke, J., van Eijndhoven, N., Vannerom, D., van Santen, J., Vara, J., Veitch-Michaelis, J., Venugopal, M., Vereecken, M., Verpoest, S., Veske, D., Vijai, A., Walck, C., Wang, A., Weaver, C., Weigel, P., Weindl, A., Weldert, J., Wen, A. Y., Wendt, C., Werthebach, J., Weyrauch, M., Whitehorn, N., Wiebusch, C. H., Williams, D. R., Witthaus, L., Wolf, A., Wolf, M., Wrede, G., Xu, X. W., Yanez, J. P., Yildizci, E., Yoshida, S., Young, R., Yu, S., Yuan, T., Zhang, Z., Zhelnin, P., Zilberman, P., Zimmerman, M., Abbasi, R., Ackermann, M., Adams, J., Agarwalla, S. K., Aguilar, J. A., Ahlers, M., Alameddine, J. M., Amin, N. M., Andeen, K., Anton, G., Argüelles, C., Ashida, Y., Athanasiadou, S., Ausborm, L., Axani, S. N., Bai, X., V., A. Balagopal, Baricevic, M., Barwick, S. W., Bash, S., Basu, V., Bay, R., Beatty, J. J., Tjus, J. Becker, Beise, J., Bellenghi, C., Benning, C., BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Blaufuss, E., Blot, S., Bontempo, F., Book, J. Y., Meneguolo, C. Boscolo, Böser, S., Botner, O., Böttcher, J., Braun, J., Brinson, B., Brostean-Kaiser, J., Brusa, L., Burley, R. T., Busse, R. S., Butterfield, D., Campana, M. A., Caracas, I., Carloni, K., Carpio, J., Chattopadhyay, S., Chau, N., Chen, Z., Chirkin, D., Choi, S., Clark, B. A., Coleman, A., Collin, G. H., Connolly, A., Conrad, J. M., Coppin, P., Corley, R., Correa, P., Cowen, D. F., Dave, P., De Clercq, C., DeLaunay, J. J., Delgado, D., Deng, S., Deoskar, K., Desai, A., Desiati, P., de Vries, K. D., de Wasseige, G., DeYoung, T., Diaz, A., Díaz-Vélez, J. C., Dittmer, M., Domi, A., Draper, L., Dujmovic, H., Dutta, K., DuVernois, M. A., Ehrhardt, T., Eidenschink, L., Eimer, A., Eller, P., Ellinger, E., Mentawi, S. El, Elsässer, D., Engel, R., Erpenbeck, H., Evans, J., Evenson, P. A., Fan, K. L., Fang, K., Farrag, K., Fazely, A. R., Fedynitch, A., Feigl, N., Fiedlschuster, S., Finley, C., Fischer, L., Fox, D., Franckowiak, A., Fürst, P., Gallagher, J., Ganster, E., Garcia, A., Genton, E., Gerhardt, L., Ghadimi, A., Girard-Carillo, C., Glaser, C., Glüsenkamp, T., Gonzalez, J. G., Goswami, S., Granados, A., Grant, D., Gray, S. J., Gries, O., Griffin, S., Griswold, S., Groth, K. M., Günther, C., Gutjahr, P., Ha, C., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Hamdaoui, H., Minh, M. Ha, Handt, M., Hanson, K., Hardin, J., Harnisch, A. A., Hatch, P., Haungs, A., Häußler, J., Helbing, K., Hellrung, J., Hermannsgabner, J., Heuermann, L., Heyer, N., Hickford, S., Hidvegi, A., Hill, C., Hill, G. C., Hoffman, K. D., Hori, S., Hoshina, K., Hostert, M., Hou, W., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., Hymon, K., Ishihara, A., Iwakiri, W., Jacquart, M., Janik, O., Jansson, M., Japaridze, G. S., Jeong, M., Jin, M., Jones, B. J. P., Kamp, N., Kang, D., Kang, W., Kang, X., Kappes, A., Kappesser, D., Kardum, L., Karg, T., Karl, M., Karle, A., Katil, A., Katz, U., Kauer, M., Kelley, J. L., Khanal, M., Zathul, A. Khatee, Kheirandish, A., Kiryluk, J., Klein, S. R., Kochocki, A., Koirala, R., Kolanoski, H., Kontrimas, T., Köpke, L., Kopper, C., Koskinen, D. J., Koundal, P., Kovacevich, M., Kowalski, M., Kozynets, T., Krishnamoorthi, J., Kruiswijk, K., Krupczak, E., Kumar, A., Kun, E., Kurahashi, N., Lad, N., Gualda, C. Lagunas, Lamoureux, M., Larson, M. J., Latseva, S., Lauber, F., Lazar, J. P., Lee, J. W., DeHolton, K. Leonard, Leszczyńska, A., Liao, J., Lincetto, M., Liubarska, M., Lohfink, E., Love, C., Mariscal, C. J. Lozano, Lu, L., Lucarelli, F., Luszczak, W., Lyu, Y., Madsen, J., Magnus, E., Mahn, K. B. M., Makino, Y., Manao, E., Mancina, S., Sainte, W. Marie, Mariş, I. C., Marka, S., Marka, Z., Marsee, M., Martinez-Soler, I., Maruyama, R., Mayhew, F., McElroy, T., McNally, F., Mead, J. V., Meagher, K., Mechbal, S., Medina, A., Meier, M., Merckx, Y., Merten, L., Micallef, J., Mitchell, J., Montaruli, T., Moore, R. W., Morii, Y., Morse, R., Moulai, M., Mukherjee, T., Naab, R., Nagai, R., Nakos, M., Naumann, U., Necker, J., Negi, A., Neumann, M., Niederhausen, H., Nisa, M. U., Noell, A., Novikov, A., Nowicki, S. C., Pollmann, A. Obertacke, O'Dell, V., Oeyen, B., Olivas, A., Orsoe, R., Osborn, J., O'Sullivan, E., Pandya, H., Park, N., Parker, G. K., Paudel, E. N., Paul, L., Heros, C. Pérez de los, Pernice, T., Peterson, J., Philippen, S., Pizzuto, A., Plum, M., Pontén, A., Popovych, Y., Rodriguez, M. Prado, Pries, B., Procter-Murphy, R., Przybylski, G. T., Raab, C., Rack-Helleis, J., Rawlins, K., Rechav, Z., Rehman, A., Reichherzer, P., Resconi, E., Reusch, S., Rhode, W., Riedel, B., Rifaie, A., Roberts, E. J., Robertson, S., Rodan, S., Roellinghoff, G., Rongen, M., Rosted, A., Rott, C., Ruhe, T., Ruohan, L., Ryckbosch, D., Safa, I., Saffer, J., Salazar-Gallegos, D., Sampathkumar, P., Sandrock, A., Santander, M., Sarkar, S., Savelberg, J., Savina, P., Schaile, P., Schaufel, M., Schieler, H., Schindler, S., Schlüter, B., Schlüter, F., Schmeisser, N., Schmidt, T., Schneider, J., Schröder, F. G., Schumacher, L., Sclafani, S., Seckel, D., Seikh, M., Seo, M., Seunarine, S., Myhr, P. Sevle, Shah, R., Shefali, S., Shimizu, N., Silva, M., Skrzypek, B., Smithers, B., Snihur, R., Soedingrekso, J., Søgaard, A., Soldin, D., Soldin, P., Sommani, G., Spannfellner, C., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stezelberger, T., Stürwald, T., Stuttard, T., Sullivan, G. W., Taboada, I., Ter-Antonyan, S., Terliuk, A., Thiesmeyer, M., Thompson, W. G., Thwaites, J., Tilav, S., Tollefson, K., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Turcotte, R., Twagirayezu, J. P., Elorrieta, M. A. Unland, Upadhyay, A. K., Upshaw, K., Vaidyanathan, A., Valtonen-Mattila, N., Vandenbroucke, J., van Eijndhoven, N., Vannerom, D., van Santen, J., Vara, J., Veitch-Michaelis, J., Venugopal, M., Vereecken, M., Verpoest, S., Veske, D., Vijai, A., Walck, C., Wang, A., Weaver, C., Weigel, P., Weindl, A., Weldert, J., Wen, A. Y., Wendt, C., Werthebach, J., Weyrauch, M., Whitehorn, N., Wiebusch, C. H., Williams, D. R., Witthaus, L., Wolf, A., Wolf, M., Wrede, G., Xu, X. W., Yanez, J. P., Yildizci, E., Yoshida, S., Young, R., Yu, S., Yuan, T., Zhang, Z., Zhelnin, P., Zilberman, P., and Zimmerman, M.
Abstract: A measurement of the diffuse astrophysical neutrino spectrum is presented using IceCube data collected from 2011-2022 (10.3 years). We developed novel detection techniques to search for events with a contained vertex and exiting track induced by muon neutrinos undergoing a charged-current interaction. Searching for these starting track events allows us to not only more effectively reject atmospheric muons but also atmospheric neutrino backgrounds in the southern sky, opening a new window to the sub-100 TeV astrophysical neutrino sky. The event selection is constructed using a dynamic starting track veto and machine learning algorithms. We use this data to measure the astrophysical diffuse flux as a single power law flux (SPL) with a best-fit spectral index of $\gamma = 2.58 ^{+0.10}_{-0.09}$ and per-flavor normalization of $\phi^{\mathrm{Astro}}_{\mathrm{per-flavor}} = 1.68 ^{+0.19}_{-0.22} \times 10^{-18} \times \mathrm{GeV}^{-1} \mathrm{cm}^{-2} \mathrm{s}^{-1} \mathrm{sr}^{-1}$ (at 100 TeV). The sensitive energy range for this dataset is 3 - 550 TeV under the SPL assumption. This data was also used to measure the flux under a broken power law, however we did not find any evidence of a low energy cutoff., Comment: 27 pages, 28 figures
Published: 2024

27. Inconsistencies within the proposed framework for stabilizing fungal nomenclature risk further confusion

Author: Sub Molecular Microbiology, Molecular Microbiology, Kidd, Sarah E., Hagen, Ferry, Halliday, Catriona L., Abdolrasouli, Alireza, Boekhout, Teun, Crous, Pedro W., Ellis, David H., Elvy, Juliet, Forrest, Graeme N., Groenewald, Marizeth, Hahn, Rosane C., Houbraken, Jos, Rodrigues, Anderson M., Scott, James, Sorrell, Tania C., Summerbell, Richard C., Tsui, Clement K.M., Yurkov, Andrey, Chen, Sharon C.A., Sub Molecular Microbiology, Molecular Microbiology, Kidd, Sarah E., Hagen, Ferry, Halliday, Catriona L., Abdolrasouli, Alireza, Boekhout, Teun, Crous, Pedro W., Ellis, David H., Elvy, Juliet, Forrest, Graeme N., Groenewald, Marizeth, Hahn, Rosane C., Houbraken, Jos, Rodrigues, Anderson M., Scott, James, Sorrell, Tania C., Summerbell, Richard C., Tsui, Clement K.M., Yurkov, Andrey, and Chen, Sharon C.A.
Published: 2024

28. Citizen Science for IceCube: Name that Neutrino

Author: Abbasi, R., Ackermann, M., Adams, J., Agarwalla, S. K., Aguilar, J. A., Ahlers, M., Alameddine, J. M., Amin, N. M., Andeen, K., Anton, G., Argüelles, C., Ashida, Y., Athanasiadou, S., Ausborm, L., Axani, S. N., Bai, X., V., A. Balagopal, Baricevic, M., Barwick, S. W., Basu, V., Bay, R., Beatty, J. J., Tjus, J. Becker, Beise, J., Bellenghi, C., Benning, C., BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Blaufuss, E., Blot, S., Bontempo, F., Book, J. Y., Meneguolo, C. Boscolo, Böser, S., Botner, O., Böttcher, J., Braun, J., Brinson, B., Brostean-Kaiser, J., Brusa, L., Burley, R. T., Busse, R. S., Butterfield, D., Campana, M. A., Caracas, I., Carloni, K., Carpio, J., Chattopadhyay, S., Chau, N., Chen, C., Chen, Z., Chirkin, D., Choi, S., Clark, B. A., Coleman, A., Collin, G. H., Connolly, A., Conrad, J. M., Coppin, P., Corley, R., Correa, P., Cowen, D. F., Dave, P., De Clercq, C., DeLaunay, J. J., Delgado, D., Deng, S., Deoskar, K., Desai, A., Desiati, P., de Vries, K. D., de Wasseige, G., DeYoung, T., Diaz, A., Díaz-Vélez, J. C., Dittmer, M., Domi, A., Draper, L., Dujmovic, H., DuVernois, M. A., Ehrhardt, T., Eimer, A., Eller, P., Ellinger, E., Mentawi, S. El, Elsässer, D., Engel, R., Erpenbeck, H., Evans, J., Evenson, P. A., Fan, K. L., Fang, K., Farrag, K., Fazely, A. R., Fedynitch, A., Feigl, N., Fiedlschuster, S., Finley, C., Fischer, L., Fox, D., Franckowiak, A., Fürst, P., Gallagher, J., Ganster, E., Garcia, A., Genton, E., Gerhardt, L., Ghadimi, A., Girard-Carillo, C., Glaser, C., Glüsenkamp, T., Gonzalez, J. G., Goswami, S., Granados, A., Grant, D., Gray, S. J., Gries, O., Griffin, S., Griswold, S., Groth, K. M., Günther, C., Gutjahr, P., Ha, C., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Hamdaoui, H., Minh, M. Ha, Handt, M., Hanson, K., Hardin, J., Harnisch, A. A., Hatch, P., Haungs, A., Häußler, J., Helbing, K., Hellrung, J., Hermannsgabner, J., Heuermann, L., Heyer, N., Hickford, S., Hidvegi, A., Hill, C., Hill, G. C., Hoffman, K. D., Hori, S., Hoshina, K., Hostert, M., Hou, W., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., Hymon, K., Ishihara, A., Iwakiri, W., Jacquart, M., Janik, O., Jansson, M., Japaridze, G. S., Jeong, M., Jin, M., Jones, B. J. P., Kamp, N., Kang, D., Kang, W., Kang, X., Kappes, A., Kappesser, D., Kardum, L., Karg, T., Karl, M., Karle, A., Katil, A., Katz, U., Kauer, M., Kelley, J. L., Khanal, M., Zathul, A. Khatee, Kheirandish, A., Kiryluk, J., Klein, S. R., Kochocki, A., Koirala, R., Kolanoski, H., Kontrimas, T., Köpke, L., Kopper, C., Koskinen, D. J., Koundal, P., Kovacevich, M., Kowalski, M., Kozynets, T., Krishnamoorthi, J., Kruiswijk, K., Krupczak, E., Kumar, A., Kun, E., Kurahashi, N., Lad, N., Gualda, C. Lagunas, Lamoureux, M., Larson, M. J., Latseva, S., Lauber, F., Lazar, J. P., Lee, J. W., DeHolton, K. Leonard, Leszczyńska, A., Lincetto, M., Liubarska, M., Lohfink, E., Love, C., Mariscal, C. J. Lozano, Lu, L., Lucarelli, F., Luszczak, W., Lyu, Y., Madsen, J., Magnus, E., Mahn, K. B. M., Makino, Y., Manao, E., Mancina, S., Sainte, W. Marie, Mariş, I. C., Marka, S., Marka, Z., Marsee, M., Martinez-Soler, I., Maruyama, R., Mayhew, F., McElroy, T., McNally, F., Mead, J. V., Meagher, K., Mechbal, S., Medina, A., Meier, M., Merckx, Y., Merten, L., Micallef, J., Mitchell, J., Montaruli, T., Moore, R. W., Morii, Y., Morse, R., Moulai, M., Mukherjee, T., Naab, R., Nagai, R., Nakos, M., Naumann, U., Necker, J., Negi, A., Neumann, M., Niederhausen, H., Nisa, M. U., Noell, A., Novikov, A., Nowicki, S. C., Pollmann, A. Obertacke, O'Dell, V., Oeyen, B., Olivas, A., Orsoe, R., Osborn, J., O'Sullivan, E., Pandya, H., Park, N., Parker, G. K., Paudel, E. N., Paul, L., Heros, C. Pérez de los, Pernice, T., Peterson, J., Philippen, S., Pizzuto, A., Plum, M., Pontén, A., Popovych, Y., Rodriguez, M. Prado, Pries, B., Procter-Murphy, R., Przybylski, G. T., Raab, C., Rack-Helleis, J., Rawlins, K., Rechav, Z., Rehman, A., Reichherzer, P., Resconi, E., Reusch, S., Rhode, W., Riedel, B., Rifaie, A., Roberts, E. J., Robertson, S., Rodan, S., Roellinghoff, G., Rongen, M., Rosted, A., Rott, C., Ruhe, T., Ruohan, L., Ryckbosch, D., Safa, I., Saffer, J., Salazar-Gallegos, D., Sampathkumar, P., Sandrock, A., Santander, M., Sarkar, S., Savelberg, J., Savina, P., Schaufel, M., Schieler, H., Schindler, S., Schlüter, B., Schlüter, F., Schmeisser, N., Schmidt, T., Schneider, J., Schröder, F. G., Schumacher, L., Sclafani, S., Seckel, D., Seikh, M., Seo, M., Seunarine, S., Myhr, P. Sevle, Shah, R., Shefali, S., Shimizu, N., Silva, M., Skrzypek, B., Smithers, B., Snihur, R., Soedingrekso, J., Søgaard, A., Soldin, D., Soldin, P., Sommani, G., Spannfellner, C., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stezelberger, T., Stürwald, T., Stuttard, T., Sullivan, G. W., Taboada, I., Ter-Antonyan, S., Terliuk, A., Thiesmeyer, M., Thompson, W. G., Thwaites, J., Tilav, S., Tollefson, K., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Tung, C. F., Turcotte, R., Twagirayezu, J. P., Elorrieta, M. A. Unland, Upadhyay, A. K., Upshaw, K., Vaidyanathan, A., Valtonen-Mattila, N., Vandenbroucke, J., van Eijndhoven, N., Vannerom, D., van Santen, J., Vara, J., Veitch-Michaelis, J., Venugopal, M., Vereecken, M., Verpoest, S., Veske, D., Vijai, A., Walck, C., Warrick, E. H. S., Weaver, C., Weigel, P., Weindl, A., Weldert, J., Wen, A. Y., Wendt, C., Werthebach, J., Weyrauch, M., Whitehorn, N., Wiebusch, C. H., Williams, D. R., Witthaus, L., Wolf, A., Wolf, M., Wrede, G., Xu, X. W., Yanez, J. P., Yildizci, E., Yoshida, S., Young, R., Yu, S., Yuan, T., Zhang, Z., Zhelnin, P., Zilberman, P., Zimmerman, M., Abbasi, R., Ackermann, M., Adams, J., Agarwalla, S. K., Aguilar, J. A., Ahlers, M., Alameddine, J. M., Amin, N. M., Andeen, K., Anton, G., Argüelles, C., Ashida, Y., Athanasiadou, S., Ausborm, L., Axani, S. N., Bai, X., V., A. Balagopal, Baricevic, M., Barwick, S. W., Basu, V., Bay, R., Beatty, J. J., Tjus, J. Becker, Beise, J., Bellenghi, C., Benning, C., BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Blaufuss, E., Blot, S., Bontempo, F., Book, J. Y., Meneguolo, C. Boscolo, Böser, S., Botner, O., Böttcher, J., Braun, J., Brinson, B., Brostean-Kaiser, J., Brusa, L., Burley, R. T., Busse, R. S., Butterfield, D., Campana, M. A., Caracas, I., Carloni, K., Carpio, J., Chattopadhyay, S., Chau, N., Chen, C., Chen, Z., Chirkin, D., Choi, S., Clark, B. A., Coleman, A., Collin, G. H., Connolly, A., Conrad, J. M., Coppin, P., Corley, R., Correa, P., Cowen, D. F., Dave, P., De Clercq, C., DeLaunay, J. J., Delgado, D., Deng, S., Deoskar, K., Desai, A., Desiati, P., de Vries, K. D., de Wasseige, G., DeYoung, T., Diaz, A., Díaz-Vélez, J. C., Dittmer, M., Domi, A., Draper, L., Dujmovic, H., DuVernois, M. A., Ehrhardt, T., Eimer, A., Eller, P., Ellinger, E., Mentawi, S. El, Elsässer, D., Engel, R., Erpenbeck, H., Evans, J., Evenson, P. A., Fan, K. L., Fang, K., Farrag, K., Fazely, A. R., Fedynitch, A., Feigl, N., Fiedlschuster, S., Finley, C., Fischer, L., Fox, D., Franckowiak, A., Fürst, P., Gallagher, J., Ganster, E., Garcia, A., Genton, E., Gerhardt, L., Ghadimi, A., Girard-Carillo, C., Glaser, C., Glüsenkamp, T., Gonzalez, J. G., Goswami, S., Granados, A., Grant, D., Gray, S. J., Gries, O., Griffin, S., Griswold, S., Groth, K. M., Günther, C., Gutjahr, P., Ha, C., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Hamdaoui, H., Minh, M. Ha, Handt, M., Hanson, K., Hardin, J., Harnisch, A. A., Hatch, P., Haungs, A., Häußler, J., Helbing, K., Hellrung, J., Hermannsgabner, J., Heuermann, L., Heyer, N., Hickford, S., Hidvegi, A., Hill, C., Hill, G. C., Hoffman, K. D., Hori, S., Hoshina, K., Hostert, M., Hou, W., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., Hymon, K., Ishihara, A., Iwakiri, W., Jacquart, M., Janik, O., Jansson, M., Japaridze, G. S., Jeong, M., Jin, M., Jones, B. J. P., Kamp, N., Kang, D., Kang, W., Kang, X., Kappes, A., Kappesser, D., Kardum, L., Karg, T., Karl, M., Karle, A., Katil, A., Katz, U., Kauer, M., Kelley, J. L., Khanal, M., Zathul, A. Khatee, Kheirandish, A., Kiryluk, J., Klein, S. R., Kochocki, A., Koirala, R., Kolanoski, H., Kontrimas, T., Köpke, L., Kopper, C., Koskinen, D. J., Koundal, P., Kovacevich, M., Kowalski, M., Kozynets, T., Krishnamoorthi, J., Kruiswijk, K., Krupczak, E., Kumar, A., Kun, E., Kurahashi, N., Lad, N., Gualda, C. Lagunas, Lamoureux, M., Larson, M. J., Latseva, S., Lauber, F., Lazar, J. P., Lee, J. W., DeHolton, K. Leonard, Leszczyńska, A., Lincetto, M., Liubarska, M., Lohfink, E., Love, C., Mariscal, C. J. Lozano, Lu, L., Lucarelli, F., Luszczak, W., Lyu, Y., Madsen, J., Magnus, E., Mahn, K. B. M., Makino, Y., Manao, E., Mancina, S., Sainte, W. Marie, Mariş, I. C., Marka, S., Marka, Z., Marsee, M., Martinez-Soler, I., Maruyama, R., Mayhew, F., McElroy, T., McNally, F., Mead, J. V., Meagher, K., Mechbal, S., Medina, A., Meier, M., Merckx, Y., Merten, L., Micallef, J., Mitchell, J., Montaruli, T., Moore, R. W., Morii, Y., Morse, R., Moulai, M., Mukherjee, T., Naab, R., Nagai, R., Nakos, M., Naumann, U., Necker, J., Negi, A., Neumann, M., Niederhausen, H., Nisa, M. U., Noell, A., Novikov, A., Nowicki, S. C., Pollmann, A. Obertacke, O'Dell, V., Oeyen, B., Olivas, A., Orsoe, R., Osborn, J., O'Sullivan, E., Pandya, H., Park, N., Parker, G. K., Paudel, E. N., Paul, L., Heros, C. Pérez de los, Pernice, T., Peterson, J., Philippen, S., Pizzuto, A., Plum, M., Pontén, A., Popovych, Y., Rodriguez, M. Prado, Pries, B., Procter-Murphy, R., Przybylski, G. T., Raab, C., Rack-Helleis, J., Rawlins, K., Rechav, Z., Rehman, A., Reichherzer, P., Resconi, E., Reusch, S., Rhode, W., Riedel, B., Rifaie, A., Roberts, E. J., Robertson, S., Rodan, S., Roellinghoff, G., Rongen, M., Rosted, A., Rott, C., Ruhe, T., Ruohan, L., Ryckbosch, D., Safa, I., Saffer, J., Salazar-Gallegos, D., Sampathkumar, P., Sandrock, A., Santander, M., Sarkar, S., Savelberg, J., Savina, P., Schaufel, M., Schieler, H., Schindler, S., Schlüter, B., Schlüter, F., Schmeisser, N., Schmidt, T., Schneider, J., Schröder, F. G., Schumacher, L., Sclafani, S., Seckel, D., Seikh, M., Seo, M., Seunarine, S., Myhr, P. Sevle, Shah, R., Shefali, S., Shimizu, N., Silva, M., Skrzypek, B., Smithers, B., Snihur, R., Soedingrekso, J., Søgaard, A., Soldin, D., Soldin, P., Sommani, G., Spannfellner, C., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stezelberger, T., Stürwald, T., Stuttard, T., Sullivan, G. W., Taboada, I., Ter-Antonyan, S., Terliuk, A., Thiesmeyer, M., Thompson, W. G., Thwaites, J., Tilav, S., Tollefson, K., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Tung, C. F., Turcotte, R., Twagirayezu, J. P., Elorrieta, M. A. Unland, Upadhyay, A. K., Upshaw, K., Vaidyanathan, A., Valtonen-Mattila, N., Vandenbroucke, J., van Eijndhoven, N., Vannerom, D., van Santen, J., Vara, J., Veitch-Michaelis, J., Venugopal, M., Vereecken, M., Verpoest, S., Veske, D., Vijai, A., Walck, C., Warrick, E. H. S., Weaver, C., Weigel, P., Weindl, A., Weldert, J., Wen, A. Y., Wendt, C., Werthebach, J., Weyrauch, M., Whitehorn, N., Wiebusch, C. H., Williams, D. R., Witthaus, L., Wolf, A., Wolf, M., Wrede, G., Xu, X. W., Yanez, J. P., Yildizci, E., Yoshida, S., Young, R., Yu, S., Yuan, T., Zhang, Z., Zhelnin, P., Zilberman, P., and Zimmerman, M.
Abstract: Name that Neutrino is a citizen science project where volunteers aid in classification of events for the IceCube Neutrino Observatory, an immense particle detector at the geographic South Pole. From March 2023 to September 2023, volunteers did classifications of videos produced from simulated data of both neutrino signal and background interactions. Name that Neutrino obtained more than 128,000 classifications by over 1,800 registered volunteers that were compared to results obtained by a deep neural network machine-learning algorithm. Possible improvements for both Name that Neutrino and the deep neural network are discussed.
Published: 2024

29. Evaluation of models of sequestration flow in coronary arteries - Physiology versus anatomy?

Author: Taylor, Daniel J., Saxton, Harry, Halliday, Ian, Newman, Tom, Feher, Jeroen, Gosling, Rebecca, Narracott, Andrew J., van Kemenade, Denise, van't Veer, Marcel, Tonino, Pim A.L., Rochette, Michel, Hose, D. Rodney, Gunn, Julian P., Morris, Paul D., Taylor, Daniel J., Saxton, Harry, Halliday, Ian, Newman, Tom, Feher, Jeroen, Gosling, Rebecca, Narracott, Andrew J., van Kemenade, Denise, van't Veer, Marcel, Tonino, Pim A.L., Rochette, Michel, Hose, D. Rodney, Gunn, Julian P., and Morris, Paul D.
Abstract: Background: Myocardial ischaemia results from insufficient coronary blood flow. Computed virtual fractional flow reserve (vFFR) allows quantification of proportional flow loss without the need for invasive pressure-wire testing. In the current study, we describe a novel, conductivity model of side branch flow, referred to as ‘leak’. This leak model is a function of taper and local pressure, the latter of which may change radically when focal disease is present. This builds upon previous techniques, which either ignore side branch flow, or rely purely on anatomical factors. This study aimed to describe a new, conductivity model of side branch flow and compare this with established anatomical models. Methods and results: The novel technique was used to quantify vFFR, distal absolute flow (Qd) and microvascular resistance (CMVR) in 325 idealised 1D models of coronary arteries, modelled from invasive clinical data. Outputs were compared to an established anatomical model of flow. The conductivity model correlated and agreed with the reference model for vFFR (r = 0.895, p < 0.0001; ＋0.02, 95% CI 0.00 to ＋ 0.22), Qd (r = 0.959, p < 0.0001; −5.2 mL/min, 95% CI −52.2 to ＋13.0) and CMVR (r = 0.624, p < 0.0001; ＋50 Woods Units, 95% CI −325 to ＋2549). Conclusion: Agreement between the two techniques was closest for vFFR, with greater proportional differences seen for Qd and CMVR. The conductivity function assumes vessel taper was optimised for the healthy state and that CMVR was not affected by local disease. The latter may be addressed with further refinement of the technique or inferred from complementary image data. The conductivity technique may represent a refinement of current techniques for modelling coronary side-branch flow. Further work is needed to validate the technique against invasive clinical data.
Published: 2024

30. Bringing an end to diabetes stigma and discrimination: an international consensus statement on evidence and recommendations

Author: Speight, J., Holmes-Truscott, E., Garza, M., Scibilia, R., Wagner, S., Kato, A., Pedrero, V., Deschênes, S., Guzman, S.J., Joiner, K.L., Liu, Shengxin, Willaing, I., Babbott, K.M., Cleal, B., Dickinson, J.K., Halliday, J.A., Morrissey, E.C., Nefs, G.M., O'Donnell, S., Serlachius, A., Winterdijk, P., Alzubaidi, H., Arifin, B., Cambron-Kopco, L., Ana, C. Santa, Davidsen, E., Groot, Mary de, Wit, M. de, Deroze, P., Haack, S., Holt, R.I.G., Jensen, W., Khunti, K., Nielsen, K. Kragelund, Lathia, T., Lee, C.J., McNulty, B., Naranjo, D., Pearl, R.L., Prinjha, S., Puhl, R.M., Sabidi, A., Selvan, C., Sethi, J., Seyam, M., Sturt, J., Subramaniam, M., Maindal, H. Terkildsen, Valentine, V., Vallis, M., Skinner, T.C., Speight, J., Holmes-Truscott, E., Garza, M., Scibilia, R., Wagner, S., Kato, A., Pedrero, V., Deschênes, S., Guzman, S.J., Joiner, K.L., Liu, Shengxin, Willaing, I., Babbott, K.M., Cleal, B., Dickinson, J.K., Halliday, J.A., Morrissey, E.C., Nefs, G.M., O'Donnell, S., Serlachius, A., Winterdijk, P., Alzubaidi, H., Arifin, B., Cambron-Kopco, L., Ana, C. Santa, Davidsen, E., Groot, Mary de, Wit, M. de, Deroze, P., Haack, S., Holt, R.I.G., Jensen, W., Khunti, K., Nielsen, K. Kragelund, Lathia, T., Lee, C.J., McNulty, B., Naranjo, D., Pearl, R.L., Prinjha, S., Puhl, R.M., Sabidi, A., Selvan, C., Sethi, J., Seyam, M., Sturt, J., Subramaniam, M., Maindal, H. Terkildsen, Valentine, V., Vallis, M., and Skinner, T.C.
Abstract: Contains fulltext : 305057.pdf (Publisher’s version ) (Closed access), People with diabetes often encounter stigma (ie, negative social judgments, stereotypes, prejudice), which can adversely affect emotional, mental, and physical health; self-care, access to optimal health care; and social and professional opportunities. To accelerate an end to diabetes stigma and discrimination, an international multidisciplinary expert panel (n=51 members, from 18 countries) conducted rapid reviews and participated in a three-round Delphi survey process. We achieved consensus on 25 statements of evidence and 24 statements of recommendations. The consensus is that diabetes stigma is driven primarily by blame, perceptions of burden or sickness, invisibility, and fear or disgust. On average, four in five adults with diabetes experience diabetes stigma and one in five experience discrimination (ie, unfair and prejudicial treatment) due to diabetes, such as in health care, education, and employment. Diabetes stigma and discrimination are harmful, unacceptable, unethical, and counterproductive. Collective leadership is needed to proactively challenge, and bring an end to, diabetes stigma and discrimination. Consequently, we achieved unanimous consensus on a pledge to end diabetes stigma and discrimination.
Published: 2024

31. Bringing an end to diabetes stigma and discrimination:an international consensus statement on evidence and recommendations

Author: Speight, Jane, Holmes-Truscott, Elizabeth, Garza, Matthew, Scibilia, Renza, Wagner, Sabina, Kato, Asuka, Pedrero, Victor, Deschênes, Sonya, Guzman, Susan J., Joiner, Kevin L., Liu, Shengxin, Willaing, Ingrid, Babbott, Katie M., Cleal, Bryan, Dickinson, Jane K., Halliday, Jennifer A., Morrissey, Eimear C., Nefs, Giesje, O'Donnell, Shane, Serlachius, Anna, Winterdijk, Per, Alzubaidi, Hamzah, Arifin, Bustanul, Cambron-Kopco, Liz, Santa Ana, Corinna, Davidsen, Emma, de Groot, Mary, de Wit, Maartje, Deroze, Phyllisa, Haack, Stephanie, Holt, Richard I.G., Jensen, Walther, Khunti, Kamlesh, Kragelund Nielsen, Karoline, Lathia, Tejal, Lee, Christopher J., McNulty, Bridget, Naranjo, Diana, Pearl, Rebecca L., Prinjha, Suman, Puhl, Rebecca M., Sabidi, Anita, Selvan, Chitra, Sethi, Jazz, Seyam, Mohammed, Sturt, Jackie, Subramaniam, Mythily, Terkildsen Maindal, Helle, Valentine, Virginia, Vallis, Michael, Skinner, Timothy C., Speight, Jane, Holmes-Truscott, Elizabeth, Garza, Matthew, Scibilia, Renza, Wagner, Sabina, Kato, Asuka, Pedrero, Victor, Deschênes, Sonya, Guzman, Susan J., Joiner, Kevin L., Liu, Shengxin, Willaing, Ingrid, Babbott, Katie M., Cleal, Bryan, Dickinson, Jane K., Halliday, Jennifer A., Morrissey, Eimear C., Nefs, Giesje, O'Donnell, Shane, Serlachius, Anna, Winterdijk, Per, Alzubaidi, Hamzah, Arifin, Bustanul, Cambron-Kopco, Liz, Santa Ana, Corinna, Davidsen, Emma, de Groot, Mary, de Wit, Maartje, Deroze, Phyllisa, Haack, Stephanie, Holt, Richard I.G., Jensen, Walther, Khunti, Kamlesh, Kragelund Nielsen, Karoline, Lathia, Tejal, Lee, Christopher J., McNulty, Bridget, Naranjo, Diana, Pearl, Rebecca L., Prinjha, Suman, Puhl, Rebecca M., Sabidi, Anita, Selvan, Chitra, Sethi, Jazz, Seyam, Mohammed, Sturt, Jackie, Subramaniam, Mythily, Terkildsen Maindal, Helle, Valentine, Virginia, Vallis, Michael, and Skinner, Timothy C.
Abstract: In 2010, the International Diabetes Federation put out a call to action to “stop discrimination against people with diabetes”.6 The International Diabetes Federation recommended enabling people with diabetes to claim their rights and responsibilities (as later detailed in their Charter4); increasing public awareness of diabetes and reducing diabetes stigma; and supporting people with diabetes to be at the centre of this response. This call to action was a novel, ambitious, and crucial step forward. In 2013, the first systematic review of diabetes stigma showed wide-ranging potential harms but a scarcity of research focused on this important issue.1 Subsequently, both advocacy and research on diabetes stigma have increased substantially, including raising awareness, sharing experiences, and understanding the nature, extent, and repercussions of diabetes stigma. Arguably, there has been greater and earlier recognition in research of the stigma associated with other health conditions (eg, cancer and mental illness in the 1960s, epilepsy in the 1970s, HIV in the 1980s–1990s, and obesity in the 2000s) than with diabetes.7, 8, 9 Insights from these areas suggest that research and advocacy, People with diabetes often encounter stigma (ie, negative social judgments, stereotypes, prejudice), which can adversely affect emotional, mental, and physical health; self-care, access to optimal health care; and social and professional opportunities. To accelerate an end to diabetes stigma and discrimination, an international multidisciplinary expert panel (n=51 members, from 18 countries) conducted rapid reviews and participated in a three-round Delphi survey process. We achieved consensus on 25 statements of evidence and 24 statements of recommendations. The consensus is that diabetes stigma is driven primarily by blame, perceptions of burden or sickness, invisibility, and fear or disgust. On average, four in five adults with diabetes experience diabetes stigma and one in five experience discrimination (ie, unfair and prejudicial treatment) due to diabetes, such as in health care, education, and employment. Diabetes stigma and discrimination are harmful, unacceptable, unethical, and counterproductive. Collective leadership is needed to proactively challenge, and bring an end to, diabetes stigma and discrimination. Consequently, we achieved unanimous consensus on a pledge to end diabetes stigma and discrimination.
Published: 2024

32. New bounds on heavy axions with an X-ray free electron laser

Author: Halliday, Jack W. D., Marocco, Giacomo, Beyer, Konstantin A., Heaton, Charles, Nakatsutsumi, Motoaki, Preston, Thomas R., Arrowsmith, Charles D., Baehtz, Carsten, Goede, Sebastian, Humphries, Oliver, Garcia, Alejandro Laso, Plackett, Richard, Svensson, Pontus, Vacalis, Georgios, Wark, Justin, Wood, Daniel, Zastrau, Ulf, Bingham, Robert, Shipsey, Ian, Sarkar, Subir, Gregori, Gianluca, Halliday, Jack W. D., Marocco, Giacomo, Beyer, Konstantin A., Heaton, Charles, Nakatsutsumi, Motoaki, Preston, Thomas R., Arrowsmith, Charles D., Baehtz, Carsten, Goede, Sebastian, Humphries, Oliver, Garcia, Alejandro Laso, Plackett, Richard, Svensson, Pontus, Vacalis, Georgios, Wark, Justin, Wood, Daniel, Zastrau, Ulf, Bingham, Robert, Shipsey, Ian, Sarkar, Subir, and Gregori, Gianluca
Abstract: We present new exclusion bounds obtained at the European X-ray Free Electron Laser facility (EuXFEL) on axion-like particles (ALPs) in the mass range 10^{-3} eV \lesssim m_a \lesssim 10^{4} eV, which is relatively unconstrained by laboratory searches. Our experiment exploits the Primakoff effect via which photons can, in the presence of a strong external electric field, decay into axions, which then convert back into photons after passing through an opaque wall. While similar searches have been performed previously at a 3$^{\rm rd}$ generation synchrotron (Yamaji et al. 2018) our work demonstrates improved sensitivity, exploiting the higher brightness of X-rays at EuXFEL., Comment: 7 pages, 6 figures
Published: 2024

33. Open challenges in the management of autoimmune hepatitis

Author: Gerussi, A, Halliday, N, Carbone, M, Invernizzi, P, Thorburn, D, Gerussi A., Halliday N., Carbone M., Invernizzi P., Thorburn D., Gerussi, A, Halliday, N, Carbone, M, Invernizzi, P, Thorburn, D, Gerussi A., Halliday N., Carbone M., Invernizzi P., and Thorburn D.
Abstract: Autoimmune hepatitis (AIH) is a rare autoimmune disease of the liver with many open questions as regards its etiopathogenesis, natural history and clinical management. The classical picture of AIH is chronic hepatitis with fluctuating elevation of serum transaminases and Immunoglobulin G levels, the presence of circulating autoantibodies and typical histological features. However, atypical presentations do occur and are not well captured by current diagnostic scores, with important consequences in terms of missed diagnoses and delayed treatments. AIH is treated with corticosteroids and immunosuppressive drugs but up to 40% of patients do not achieve full biochemical response and are at risk of progressing to cirrhosis and liver failure. Moreover, standard therapies are associated by significant side-effects which may impair the quality of life of patients living with AIH. However, advances in the understanding of the underlying immunology of AIH is raising the prospect of novel therapies and optimization of existing therapeutic approaches to reduce side-effect burdens and potentially restore immunological tolerance. In this review we outlined the clinical characteristics, etiopathogenesis and management of AIH and current challenges in the diagnosis and management of AIH and provided evidence underlying the evolution of diagnostic and clinical management protocols.
Published: 2023

34. Bacterascites confers poor patient prognosis beyond MELD prediction

Author: King, J, Halliday, N, Mantovani, A, Gerussi, A, Wey, E, Tan, J, Ryan, J, Patch, D, Tsochatzis, E, Westbrook, R, King J. J., Halliday N., Mantovani A., Gerussi A., Wey E. Q., Tan J., Ryan J., Patch D., Tsochatzis E., Westbrook R. H., King, J, Halliday, N, Mantovani, A, Gerussi, A, Wey, E, Tan, J, Ryan, J, Patch, D, Tsochatzis, E, Westbrook, R, King J. J., Halliday N., Mantovani A., Gerussi A., Wey E. Q., Tan J., Ryan J., Patch D., Tsochatzis E., and Westbrook R. H.
Abstract: Spontaneous bacterial peritonitis (SBP) is a well-recognized clinical entity with a poor prognosis. In comparison, the prevalence, microbiological flora, and prognostic significance of bacterascites (BA) (the presence of organism on culture but ascitic PMN <250 cells/mm(3)) is largely unknown. We, therefore, assessed the prognosis and predictors of outcome in patients with BA in comparison with those with SBP. Ascitic fluid cultures from consecutive patients with cirrhosis from 2008 to 2018 were reviewed retrospectively, and patients with SBP and BA were identified. Baseline demographic, laboratory, and microbiological data were collated and analyzed as prognostic indicators, and clinical outcomes were recorded. Patients were censored at the time of LT, death, or last follow-up. For this study 176 and 213 cases of SBP and BA, respectively, were identified and included. Patients with SBP had significantly higher Model for End-Stage Liver Disease (MELD) (p=<0.01), peripheral blood WCC (p < 0.01), and higher rates of Enterobacteriaceae (p < 0.01) and multi-drug resistant pathogens (p < 0.01). Survival at 1 and 3 months was lower in patients with SBP (p < 0.01) when compared with BA but at 6 months and beyond, no significant difference remained. After the exclusion of deaths within 30 days of presentation, survival between SBP and BA was equivocal at all time points. Mortality was substantially higher across all MELD groupings for both SBP and BA when compared with the predicted mortality calculated by the MELD score alone. BA has a negative impact on patient survival above that predicted by the MELD score. It has similar impact to SBP on patient survival beyond 1 month suggesting it should be seen as a poor prognostic marker and prompt consideration of LT where appropriate. Further studies evaluating the role of secondary prophylaxis in this group are required.
Published: 2023

35. Systematic review of response criteria and endpoints in autoimmune hepatitis by the International Autoimmune Hepatitis Group

Author: Pape, S, Snijders, R, Gevers, T, Chazouilleres, O, Dalekos, G, Hirschfield, G, Lenzi, M, Trauner, M, Manns, M, Vierling, J, Montano-Loza, A, Lohse, A, Schramm, C, Drenth, J, Heneghan, M, Almasio, P, Alvarez, F, Andrade, R, Arikan, C, Assis, D, Bardou-Jacquet, E, Biewenga, M, Cancado, E, Cazzagon, N, Colloredo, G, Cuarterolo, M, Debray, D, Robles-Diaz, M, Dyson, J, Efe, C, Engel, B, Ferri, S, Fontana, R, Gatselis, N, Gerussi, A, Halilbasic, E, Halliday, N, van Hoek, B, Horby Jorgensen, M, Indolfini, G, Iorio, R, Jeong, S, Jones, D, Kelly, D, Kerkar, N, Lacaille, F, Lammert, C, Leggett, B, Levy, C, Liberal, R, Lleo, A, Ines Lopez, S, de Martin, E, Mclin, V, Mieli-Vergani, G, Milkiewicz, P, Mohan, N, Muratori, L, Nebbia, G, van Nieuwkerk, C, Oo, Y, Ortega, A, Pares, A, Pop, T, Pratt, D, Purnak, T, Ranucci, G, Rushbrook, S, Stattermayer, A, Swain, M, Tanaka, A, Taubert, R, Terrabuio, D, Terziroli, B, Valentino, P, van den Brand, F, Villamil, A, Wahlin, S, Ytting, H, Zachou, K, Zeniya, M, Pape S., Snijders R. J. A. L. M., Gevers T. J. G., Chazouilleres O., Dalekos G. N., Hirschfield G. M., Lenzi M., Trauner M., Manns M. P., Vierling J. M., Montano-Loza A. J., Lohse A. W., Schramm C., Drenth J. P. H., Heneghan M. A., Almasio P., Alvarez F., Andrade R., Arikan C., Assis D., Bardou-Jacquet E., Biewenga M., Cancado E., Cazzagon N., Colloredo G., Cuarterolo M., Dalekos G., Debray D., Robles-Diaz M., Drenth J., Dyson J., Efe C., Engel B., Ferri S., Fontana R., Gatselis N., Gerussi A., Halilbasic E., Halliday N., Heneghan M., Hirschfield G., van Hoek B., Horby Jorgensen M., Indolfini G., Iorio R., Jeong S., Jones D., Kelly D., Kerkar N., Lacaille F., Lammert C., Leggett B., Levy C., Liberal R., Lleo A., Lohse A., Ines Lopez S., de Martin E., McLin V., Mieli-Vergani G., Milkiewicz P., Mohan N., Muratori L., Nebbia G., van Nieuwkerk C., Oo Y., Ortega A., Pares A., Pop T., Pratt D., Purnak T., Ranucci G., Rushbrook S., Stattermayer A., Swain M., Tanaka A., Taubert R., Terrabuio D., Terziroli B., Valentino P., van den Brand F., Villamil A., Wahlin S., Ytting H., Zachou K., Zeniya M., Pape, S, Snijders, R, Gevers, T, Chazouilleres, O, Dalekos, G, Hirschfield, G, Lenzi, M, Trauner, M, Manns, M, Vierling, J, Montano-Loza, A, Lohse, A, Schramm, C, Drenth, J, Heneghan, M, Almasio, P, Alvarez, F, Andrade, R, Arikan, C, Assis, D, Bardou-Jacquet, E, Biewenga, M, Cancado, E, Cazzagon, N, Colloredo, G, Cuarterolo, M, Debray, D, Robles-Diaz, M, Dyson, J, Efe, C, Engel, B, Ferri, S, Fontana, R, Gatselis, N, Gerussi, A, Halilbasic, E, Halliday, N, van Hoek, B, Horby Jorgensen, M, Indolfini, G, Iorio, R, Jeong, S, Jones, D, Kelly, D, Kerkar, N, Lacaille, F, Lammert, C, Leggett, B, Levy, C, Liberal, R, Lleo, A, Ines Lopez, S, de Martin, E, Mclin, V, Mieli-Vergani, G, Milkiewicz, P, Mohan, N, Muratori, L, Nebbia, G, van Nieuwkerk, C, Oo, Y, Ortega, A, Pares, A, Pop, T, Pratt, D, Purnak, T, Ranucci, G, Rushbrook, S, Stattermayer, A, Swain, M, Tanaka, A, Taubert, R, Terrabuio, D, Terziroli, B, Valentino, P, van den Brand, F, Villamil, A, Wahlin, S, Ytting, H, Zachou, K, Zeniya, M, Pape S., Snijders R. J. A. L. M., Gevers T. J. G., Chazouilleres O., Dalekos G. N., Hirschfield G. M., Lenzi M., Trauner M., Manns M. P., Vierling J. M., Montano-Loza A. J., Lohse A. W., Schramm C., Drenth J. P. H., Heneghan M. A., Almasio P., Alvarez F., Andrade R., Arikan C., Assis D., Bardou-Jacquet E., Biewenga M., Cancado E., Cazzagon N., Colloredo G., Cuarterolo M., Dalekos G., Debray D., Robles-Diaz M., Drenth J., Dyson J., Efe C., Engel B., Ferri S., Fontana R., Gatselis N., Gerussi A., Halilbasic E., Halliday N., Heneghan M., Hirschfield G., van Hoek B., Horby Jorgensen M., Indolfini G., Iorio R., Jeong S., Jones D., Kelly D., Kerkar N., Lacaille F., Lammert C., Leggett B., Levy C., Liberal R., Lleo A., Lohse A., Ines Lopez S., de Martin E., McLin V., Mieli-Vergani G., Milkiewicz P., Mohan N., Muratori L., Nebbia G., van Nieuwkerk C., Oo Y., Ortega A., Pares A., Pop T., Pratt D., Purnak T., Ranucci G., Rushbrook S., Stattermayer A., Swain M., Tanaka A., Taubert R., Terrabuio D., Terziroli B., Valentino P., van den Brand F., Villamil A., Wahlin S., Ytting H., Zachou K., and Zeniya M.
Abstract: Background & Aims: Autoimmune hepatitis (AIH) has been well characterised and codified through the development of diagnostic criteria. These criteria have been adapted and simplified and are widely used in clinical practice. However, there is a need to update and precisely define the criteria for both treatment response and treatment. Methods: A systematic review was performed and a modified Delphi consensus process was used to identify and redefine the response criteria in autoimmune hepatitis. Results: The consensus process initiated by the International Autoimmune Hepatitis Group proposes that the term ‘complete biochemical response’ defined as ‘normalization of serum transaminases and IgG below the upper limit of normal’ be adopted to include a time point at 6 months after initiation of treatment. An insufficient response by 6 months was a failure to meet the above definition. Non-response was defined as ‘<50% decrease of serum transaminases within 4 weeks after initiation of treatment’. Remission is defined as liver histology with a Hepatitis Activity Index <4/18. Intolerance to treatment was agreed to stand for ‘any adverse event possibly related to treatment leading to potential drug discontinuation’. Conclusions: These definitions provide a simple and reproducible framework to define treatment response and non-response, irrespective of the therapeutic intervention. A consensus on endpoints is urgently required to set a global standard for the reporting of study results and to enable inter-study comparisons. Future prospective database studies are needed to validate these endpoints. Lay summary: Consensus among international experts on response criteria and endpoints in autoimmune hepatitis is lacking. A consensus on endpoints is urgently required to set a global standard for the reporting of study results and to enable the comparison of results between clinical trials. Therefore, the International Autoimmune Hepatitis Group (IAIHG) herein presents
Published: 2022

36. European Society for Vascular Surgery (ESVS) 2023 Clinical Practice Guidelines on the Management of Atherosclerotic Carotid and Vertebral Artery Disease

Author: Naylor, Ross, Rantner, Barbara, Ancetti, Stefano, de Borst, Gert J., De Carlo, Marco, Halliday, Alison, Kakkos, Stavros K., Markus, Hugh S., McCabe, Dominick J. H., Sillesen, Henrik, van den Berg, Jos C., Vega de Ceniga, Melina, Venermo, Maarit A., Vermassen, Frank E. G., Antoniou, George A., Goncalves, Frederico Bastos, Björck, Martin, Chakfe, Nabil, Coscas, Raphael, Dias, Nuno V., Dick, Florian, Hinchliffe, Robert J., Kolh, Philippe, Koncar, Igor B., Lindholt, Jes S., Mees, Barend M. E., Resch, Timothy A., Trimarchi, Santi, Tulamo, Riikka, Twine, Christopher P., Wanhainen, Anders, Bellmunt-Montoya, Sergi, Bulbulia, Richard, Darling, R. Clement, III, Eckstein, Hans-Henning, Giannoukas, Athanasios, Koelemay, Mark J. W., Lindström, David, Schermerhorn, Marc, Stone, David H., Naylor, Ross, Rantner, Barbara, Ancetti, Stefano, de Borst, Gert J., De Carlo, Marco, Halliday, Alison, Kakkos, Stavros K., Markus, Hugh S., McCabe, Dominick J. H., Sillesen, Henrik, van den Berg, Jos C., Vega de Ceniga, Melina, Venermo, Maarit A., Vermassen, Frank E. G., Antoniou, George A., Goncalves, Frederico Bastos, Björck, Martin, Chakfe, Nabil, Coscas, Raphael, Dias, Nuno V., Dick, Florian, Hinchliffe, Robert J., Kolh, Philippe, Koncar, Igor B., Lindholt, Jes S., Mees, Barend M. E., Resch, Timothy A., Trimarchi, Santi, Tulamo, Riikka, Twine, Christopher P., Wanhainen, Anders, Bellmunt-Montoya, Sergi, Bulbulia, Richard, Darling, R. Clement, III, Eckstein, Hans-Henning, Giannoukas, Athanasios, Koelemay, Mark J. W., Lindström, David, Schermerhorn, Marc, and Stone, David H.
Published: 2023
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37. Short tandem repeat expansions in sporadic amyotrophic lateral sclerosis and frontotemporal dementia

Author: Henden, L, Fearnley, LG, Grima, N, McCann, EP, Dobson-Stone, C, Fitzpatrick, L, Friend, K, Hobson, L, Fat, SCM, Rowe, DB, D'Silva, S, Kwok, JB, Halliday, GM, Kiernan, MC, Mazumder, S, Timmins, HC, Zoing, M, Pamphlett, R, Adams, L, Bahlo, M, Blair, IP, Williams, KL, Henden, L, Fearnley, LG, Grima, N, McCann, EP, Dobson-Stone, C, Fitzpatrick, L, Friend, K, Hobson, L, Fat, SCM, Rowe, DB, D'Silva, S, Kwok, JB, Halliday, GM, Kiernan, MC, Mazumder, S, Timmins, HC, Zoing, M, Pamphlett, R, Adams, L, Bahlo, M, Blair, IP, and Williams, KL
Abstract: Pathogenic short tandem repeat (STR) expansions cause over 20 neurodegenerative diseases. To determine the contribution of STRs in sporadic amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), we used ExpansionHunter, REviewer, and polymerase chain reaction validation to assess 21 neurodegenerative disease-associated STRs in whole-genome sequencing data from 608 patients with sporadic ALS, 68 patients with sporadic FTD, and 4703 matched controls. We also propose a data-derived outlier detection method for defining allele thresholds in rare STRs. Excluding C9orf72 repeat expansions, 17.6% of clinically diagnosed ALS and FTD cases had at least one expanded STR allele reported to be pathogenic or intermediate for another neurodegenerative disease. We identified and validated 162 disease-relevant STR expansions in C9orf72 (ALS/FTD), ATXN1 [spinal cerebellar ataxia type 1 (SCA1)], ATXN2 (SCA2), ATXN8 (SCA8), TBP (SCA17), HTT (Huntington's disease), DMPK [myotonic dystrophy type 1 (DM1)], CNBP (DM2), and FMR1 (fragile-X disorders). Our findings suggest clinical and pathological pleiotropy of neurodegenerative disease genes and highlight their importance in ALS and FTD.
Published: 2023

38. 25 Years of thermomorphogenesis research: milestones and perspectives

Author: Quint, Marcel, Delker, Carolin, Balasubramanian, Sureshkumar, Balcerowicz, Martin, Casal, Jorge J, Castroverde, Christian Danve M, Chen, Meng, Chen, Xuemei, De Smet, Ive, Fankhauser, Christian, Franklin, Keara A, Halliday, Karen J, Hayes, Scott, Jiang, Danhua, Jung, Jae-Hoon, Kaiserli, Eirini, Kumar, S Vinod, Maag, Daniel, Oh, Eunkyoo, Park, Chung-Mo, Penfield, Steven, Perrella, Giorgio, Prat, Salomé, Reis, Rodrigo S, Wigge, Philip A, Willige, Björn C, van Zanten, Martijn, Quint, Marcel, Delker, Carolin, Balasubramanian, Sureshkumar, Balcerowicz, Martin, Casal, Jorge J, Castroverde, Christian Danve M, Chen, Meng, Chen, Xuemei, De Smet, Ive, Fankhauser, Christian, Franklin, Keara A, Halliday, Karen J, Hayes, Scott, Jiang, Danhua, Jung, Jae-Hoon, Kaiserli, Eirini, Kumar, S Vinod, Maag, Daniel, Oh, Eunkyoo, Park, Chung-Mo, Penfield, Steven, Perrella, Giorgio, Prat, Salomé, Reis, Rodrigo S, Wigge, Philip A, Willige, Björn C, and van Zanten, Martijn
Abstract: In 1998, Bill Gray and colleagues showed that warm temperatures trigger arabidopsis hypocotyl elongation in an auxin-dependent manner. This laid the foundation for a vibrant research discipline. With several active members of the 'thermomorphogenesis' community, we here reflect on 25 years of elevated ambient temperature research and look to the future.
Published: 2023

39. Transnational Legal Order Through Rule of Law? Appraising the United Nations Security Council, 1990-2022

Author: Farrall, Jeremy, Farrall, Jeremy, Halliday, Terence, Farrall, Jeremy, Farrall, Jeremy, and Halliday, Terence
Abstract: Utilizing the theoretical framework of transnational legal orders (TLOs), this article treats two master questions in global governance: what are the limits to the power of the UN Security Council? Can norms of rule-of-law constrain UNSC powers? First, we outline a research design with emphasis on its documentary and unique internal empirical sources. Second, we sketch an interpretive narrative of UNSC engagement from the early 1990s to the present with ROL in three areas of UNSC action: peacekeeping, sanctions, and force. Third, we offer a new conceptual approach by proposing that ROL in the UNSC manifests itself in three dimensions: discourse; procedure (or rules); and structures. These dimensions come into play both internally, within the UNSC itself, and externally, to ROL institution-building in and between states, as well as in post-conflict zones, with a rather gray area between (e.g., when the UN peacekeeping missions are themselves subject to ROL oversight for the behavior of their personnel). Fourth, we examine the emergence of micro-TLOs under construction within the UNSC itself. We conclude with reflections on the potential for empowering elected members of the UNSC and weaker states in the UN to press ROL norms on the UNSC as a springboard for ROL global governance via the UNSC.
Published: 2023

40. LATE-NC staging in routine neuropathologic diagnosis: an update.

Author: Nelson, Peter T, Nelson, Peter T, Lee, Edward B, Cykowski, Matthew D, Alafuzoff, Irina, Arfanakis, Konstantinos, Attems, Johannes, Brayne, Carol, Corrada, Maria M, Dugger, Brittany N, Flanagan, Margaret E, Ghetti, Bernardino, Grinberg, Lea T, Grossman, Murray, Grothe, Michel J, Halliday, Glenda M, Hasegawa, Masato, Hokkanen, Suvi RK, Hunter, Sally, Jellinger, Kurt, Kawas, Claudia H, Keene, C Dirk, Kouri, Naomi, Kovacs, Gabor G, Leverenz, James B, Latimer, Caitlin S, Mackenzie, Ian R, Mao, Qinwen, McAleese, Kirsty E, Merrick, Richard, Montine, Thomas J, Murray, Melissa E, Myllykangas, Liisa, Nag, Sukriti, Neltner, Janna H, Newell, Kathy L, Rissman, Robert A, Saito, Yuko, Sajjadi, S Ahmad, Schwetye, Katherine E, Teich, Andrew F, Thal, Dietmar R, Tomé, Sandra O, Troncoso, Juan C, Wang, Shih-Hsiu J, White, Charles L, Wisniewski, Thomas, Yang, Hyun-Sik, Schneider, Julie A, Dickson, Dennis W, Neumann, Manuela, Nelson, Peter T, Nelson, Peter T, Lee, Edward B, Cykowski, Matthew D, Alafuzoff, Irina, Arfanakis, Konstantinos, Attems, Johannes, Brayne, Carol, Corrada, Maria M, Dugger, Brittany N, Flanagan, Margaret E, Ghetti, Bernardino, Grinberg, Lea T, Grossman, Murray, Grothe, Michel J, Halliday, Glenda M, Hasegawa, Masato, Hokkanen, Suvi RK, Hunter, Sally, Jellinger, Kurt, Kawas, Claudia H, Keene, C Dirk, Kouri, Naomi, Kovacs, Gabor G, Leverenz, James B, Latimer, Caitlin S, Mackenzie, Ian R, Mao, Qinwen, McAleese, Kirsty E, Merrick, Richard, Montine, Thomas J, Murray, Melissa E, Myllykangas, Liisa, Nag, Sukriti, Neltner, Janna H, Newell, Kathy L, Rissman, Robert A, Saito, Yuko, Sajjadi, S Ahmad, Schwetye, Katherine E, Teich, Andrew F, Thal, Dietmar R, Tomé, Sandra O, Troncoso, Juan C, Wang, Shih-Hsiu J, White, Charles L, Wisniewski, Thomas, Yang, Hyun-Sik, Schneider, Julie A, Dickson, Dennis W, and Neumann, Manuela
Abstract: An international consensus report in 2019 recommended a classification system for limbic-predominant age-related TDP-43 encephalopathy neuropathologic changes (LATE-NC). The suggested neuropathologic staging system and nomenclature have proven useful for autopsy practice and dementia research. However, some issues remain unresolved, such as cases with unusual features that do not fit with current diagnostic categories. The goal of this report is to update the neuropathologic criteria for the diagnosis and staging of LATE-NC, based primarily on published data. We provide practical suggestions about how to integrate available genetic information and comorbid pathologies [e.g., Alzheimer's disease neuropathologic changes (ADNC) and Lewy body disease]. We also describe recent research findings that have enabled more precise guidance on how to differentiate LATE-NC from other subtypes of TDP-43 pathology [e.g., frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS)], and how to render diagnoses in unusual situations in which TDP-43 pathology does not follow the staging scheme proposed in 2019. Specific recommendations are also made on when not to apply this diagnostic term based on current knowledge. Neuroanatomical regions of interest in LATE-NC are described in detail and the implications for TDP-43 immunohistochemical results are specified more precisely. We also highlight questions that remain unresolved and areas needing additional study. In summary, the current work lays out a number of recommendations to improve the precision of LATE-NC staging based on published reports and diagnostic experience.
Published: 2023

41. The mental health and wellbeing impact of a Community Wealth Building programme in England:a difference-in-differences study

Author: Rose, Tanith C, Daras, Konstantinos, Manley, Julian, McKeown, Mick, Halliday, Emma, Goodwin, Tom Lloyd, Hollingsworth, Bruce, Barr, Ben, Rose, Tanith C, Daras, Konstantinos, Manley, Julian, McKeown, Mick, Halliday, Emma, Goodwin, Tom Lloyd, Hollingsworth, Bruce, and Barr, Ben
Abstract: Background Wide differences in health exist between places in the UK, underscored by economic inequalities. Preston, an economically disadvantaged city in England, implemented a new approach to economic development, known as the Community Wealth Building programme. Public and non-profit organisations modified their procurement policies to support the development of local supply chains, improve employment conditions, and increase socially productive use of wealth and assets. We aimed to investigate the effect of this programme on population mental health and wellbeing. Methods Difference-in-differences techniques compared trends in mental health outcomes in Preston, relative to matched control areas before (2011–15) and after (2016–19) the introduction of the programme. Outcomes were antidepressant prescribing, prevalence of depression, and mental health related hospital attendance rates using data provided by National Health Service Digital, the Quality and Outcomes Framework, and the Office for National Statistics. Additional analysis compared local authority measures of life satisfaction, median wages, and employment with synthetic counterfactuals created using Bayesian Structural Time Series. Findings The introduction of the Community Wealth Building programme was associated with reductions in the prescribing of antidepressants (1·3 average daily quantities per person [95% CI 0·72–1·78) and prevalence of depression (2·4 per 1000 population [0·42–4·46]), relative to the control areas. The local population also experienced a 9% improvement in life satisfaction (95% credible interval 0–19·6%) and 11% increase in median wages (1·8–18·9%), relative to expected trends. Associations with employment and mental health related hospital attendance outcomes did not reach statistical significance. Interpretation During the period in which the Community Wealth Building programme was introduced, there were fewer mental health problems than would have been expected compared with
Published: 2023

42. Low-Intensity mental health Support via a Telehealth Enabled Network for adults with diabetes (LISTEN): protocol for a hybrid type 1 effectiveness implementation trial.

Author: Holloway, Edith E, Gray, Shikha, Mihalopoulos, Cathrine, Versace, Vincent L, Gautier, Roslyn Le, Chatterton, Mary Lou, Hagger, Virginia, Halliday, Jennifer, Henshaw, Kim, Harrap, Benjamin, Manallack, Sarah, Black, Taryn, Bruggen, Natasha Van, Hines, Carolyn, O'Neil, Adrienne, Skinner, Timothy, Speight, Jane, Hendrieckx, Christel, Holloway, Edith E, Gray, Shikha, Mihalopoulos, Cathrine, Versace, Vincent L, Gautier, Roslyn Le, Chatterton, Mary Lou, Hagger, Virginia, Halliday, Jennifer, Henshaw, Kim, Harrap, Benjamin, Manallack, Sarah, Black, Taryn, Bruggen, Natasha Van, Hines, Carolyn, O'Neil, Adrienne, Skinner, Timothy, Speight, Jane, and Hendrieckx, Christel
Published: 2023

43. Retrofit-induced changes in the radiated noise and monopole source levels of container ships.

Author: ZoBell, Vanessa M, Halliday, William David1, ZoBell, Vanessa M, Gassmann, Martin, Kindberg, Lee B, Wiggins, Sean M, Hildebrand, John A, Frasier, Kaitlin E, ZoBell, Vanessa M, Halliday, William David1, ZoBell, Vanessa M, Gassmann, Martin, Kindberg, Lee B, Wiggins, Sean M, Hildebrand, John A, and Frasier, Kaitlin E
Abstract: The container shipping line Maersk undertook a Radical Retrofit to improve the energy efficiency of twelve sister container ships. Noise reduction, identified as a potential added benefit of the retrofitting effort, was investigated in this study. A passive acoustic recording dataset from the Santa Barbara Channel off Southern California was used to compile over 100 opportunistic vessel transits of the twelve G-Class container ships, pre- and post-retrofit. Post-retrofit, the G-Class vessels' capacity was increased from ~9,000 twenty-foot equivalent units (TEUs) to ~11,000 TEUs, which required a draft increase of the vessel by 1.5 m on average. The increased vessel draft resulted in higher radiated noise levels (<2 dB) in the mid- and high-frequency bands. Accounting for the Lloyd's mirror (dipole source) effect, the monopole source levels of the post-retrofit ships were found to be significantly lower (>5 dB) than the pre-retrofit ships in the low-frequency band and the reduction was greatest at low speed. Although multiple design changes occurred during retrofitting, the reduction in the low-frequency band most likely results from a reduction in cavitation due to changes in propeller and bow design.
Published: 2023

44. Knowledge exchange in crisis settings:A scoping review

Author: Zia, Asim, McGill, Elizabeth, Halliday, Emma, Egan, Matthew, Popay, Jennie, Zia, Asim, McGill, Elizabeth, Halliday, Emma, Egan, Matthew, and Popay, Jennie
Abstract: Background: Public health practice and efforts to improve the social determinants of health operate within a climate characterised by multiple and intersecting crises. This includes the Covid-19 pandemic as well as more protracted crises such as climate change and persistent social inequalities that impact health. We sought to understand and compare how knowledge exchange (KE) processes occur across different crises, and how knowledge on improving social determinants of health can be utilised at times of crisis to reduce health inequalities and strengthen public systems. Methods: We conducted a scoping review to understand how KE on improving social determinants of health can occur across different types of crises (e.g. environmental, pandemics, humanitarian). Relevant studies were identified through electronic searching of Medline, EMBASE, Global Health, Scopus and Web of Science databases. Results: We identified 86 studies for inclusion in the review. Most studies concerned pandemic or environmental crises. Fewer studies explored KE during technical (e.g. nuclear), terror-related or humanitarian crises. This may reflect a limitation of the searches. Few studies assessed KE as part of longer-term responses to social and economic impacts of crises, with studies more likely to focus on immediate response or early recovery stages. Exchange of research evidence or data with policy or practice contextual knowledge was common but there was variation in the extent that lay (public) knowledge was included as part of KE processes. Conclusion: As ongoing crises continue with significant public health implications, KE processes should appropriately reflect the complexity inherent in crises and foreground health inequalities. Doing so could include the utilisation of systems or complexity-informed methods to support planning and evaluation of KE, a greater focus on KE to support action to address social determinants of health, and the inclusion of a plurality of knowledge–incl
Published: 2023

45. Strengthening the equity focus of applied public health research:introducing the FOR EQUITY platform

Author: Popay, J., Chekar, C.K., Griffiths, A., Halliday, E., Kaloudis, H., Leiper, R., Panagaki, K., Porroche-Escudero, A., Popay, J., Chekar, C.K., Griffiths, A., Halliday, E., Kaloudis, H., Leiper, R., Panagaki, K., and Porroche-Escudero, A.
Abstract: Objectives: Much applied health research pays insufficient attention to potential unequal impacts across social groups or is typically focused on a single dimension (e.g. socio-economic status), rarely considering the intersecting social processes driving inequalities (e.g. racism, sexism, classism). All health research needs a strong intersectional equity focus in order to inform action to reduce health inequalities as well as improve population health. Study design: Focus On Research and Equity (FOR EQUITY) is a new Web-based platform aiming to strengthen the intersectional equity focus of applied health research. Methods: The platform was developed in collaboration with members of the public, practitioners and researchers working internationally. The development involved a systematic review of academic and grey literature, a series of workshops and user testing. Results: FOR EQUITY encompasses (1) a Health Inequalities Assessment Tool, with an intersectional perspective on inequalities; (2) a FOR EQUITY Guidance Inventory providing access to a range of international research toolkits and guidance; and (3) a FOR EQUITY Library including case studies illustrating how researchers have attempted to integrate an equity lens into the research process and more general resources on health inequalities. Conclusion: FOR EQUITY can support researchers to strengthen the equity lens in their studies to make research evidence more relevant for action to reduce social and health inequalities. However, a single focus on toolkits is unlikely to sufficiently address the barriers to embedding equity in research. A mainstreaming strategy to transform the very roots of the ‘institution of research’ is required. © 2022
Published: 2023

46. Strategies for knowledge exchange for action to address place-based determinants of health inequalities:an umbrella review

Author: Halliday, E, Tompson, A, McGill, E, Egan, M, Popay, J, Halliday, E, Tompson, A, McGill, E, Egan, M, and Popay, J
Abstract: Background Place-based health inequalities persist despite decades of academics and other stakeholders generating ideas and evidence on how to reduce them. This may in part reflect a failure in effective knowledge exchange (KE). We aim to understand what KE strategies are effective in supporting actions on place-based determinants and the barriers and facilitators to this KE. Methods An umbrella review was undertaken to identify relevant KE strategies. Systematic reviews were identified by searching academic databases (Medline, Embase, Scopus, Web of Science) and handsearching. Synthesis involved charting and thematic analysis. Results Fourteen systematic reviews were included comprising 105 unique, relevant studies. Four approaches to KE were identified: improving access to knowledge, collaborative approaches, participatory models and KE as part of advocacy. While barriers and facilitators were reported, KE approaches were rarely evaluated for their effectiveness. Conclusions Based on these four approaches, our review produced a framework, which may support planning of future KE strategies. The findings also suggest the importance of attending to political context, including the ways in which this may impede a more upstream place-based focus in favour of behavioural interventions and the extent that researchers are willing to engage with politicized agendas.
Published: 2023

47. The Mental Health And Wellbeing Impact of A Community Wealth Building Programme – A Difference-In-Differences Study

Author: Rose, Tanith, Daras, Konstantinos, Manley, Julian Y, Mckeown, Michael, Halliday, Emma, Goodwin, Tom Lloyd, Hollingsworth, Bruce, Barr, Ben, Rose, Tanith, Daras, Konstantinos, Manley, Julian Y, Mckeown, Michael, Halliday, Emma, Goodwin, Tom Lloyd, Hollingsworth, Bruce, and Barr, Ben
Abstract: Background Wide differences in health exist between places in the UK, underscored by economic inequalities. Preston, a relatively deprived city in England, implemented a new approach to economic development, known as Community Wealth Building. Public and non-profit organisations modified their procurement policies to support the development of local supply chains, improve employment conditions, and increase socially productive use of wealth and assets. We evaluate the impact of this programme on population mental health and wellbeing. Methods Difference-in-differences techniques compared trends in mental health outcomes in Preston, relative to matched control areas before (2011-2015) and after (2016-2019) the introduction of Community Wealth Building. Additional analysis compared local authority measures of life satisfaction, median wages, and employment to synthetic counterfactuals created using Bayesian structural time-series. Findings The introduction of Community Wealth Building was associated with reductions in antidepressant prescribing (1.3 ADQs/person [95%CI, 0.72–1.78]) and depression prevalence (2.4 per 1000 population [95%CI, 0.42–4.46]), relative to the control areas. The local population also experienced a 9% improvement in life satisfaction (95%Cr I, 0%–20%) and 11% increase in median wages (95%Cr I, 2%–19%), relative to expected trends. Associations with employment and mental health related hospital attendance outcomes, did not reach statistical significance. Interpretation During the period in which Community Wealth Building was introduced there were fewer mental health problems than would have been expected compared to other similar areas, as life satisfaction and economic measures improved. This approach potentially provides an effective model for economic regeneration leading to substantial health benefits.
Published: 2023

48. Limits on Neutrino Emission from GRB 221009A from MeV to PeV using the IceCube Neutrino Observatory

Author: Abbasi, R., Ackermann, M., Adams, J., Agarwalla, S. K., Aggarwal, N., Aguilar, J. A., Ahlers, M., Alameddine, J. M., Amin, N. M., Andeen, K., Anton, G., Argüelles, C., Ashida, Y., Athanasiadou, S., Axani, S. N., Bai, X., V., A. Balagopal, Baricevic, M., Barwick, S. W., Basu, V., Bay, R., Beatty, J. J., Becker, K. -H., Tjus, J. Becker, Beise, J., Bellenghi, C., BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Bindig, D., Blaufuss, E., Blot, S., Bontempo, F., Book, J. Y., Borowka, J., Meneguolo, C. Boscolo, Böser, S., Botner, O., Böttcher, J., Bourbeau, E., Braun, J., Brinson, B., Brostean-Kaiser, J., Burley, R. T., Busse, R. S., Campana, M. A., Carloni, K., Carnie-Bronca, E. G., Chen, C., Chen, Z., Chirkin, D., Choi, S., Clark, B. A., Classen, L., Coleman, A., Collin, G. H., Connolly, A., Conrad, J. M., Coppin, P., Correa, P., Countryman, S., Cowen, D. F., Dappen, C., Dave, P., De Clercq, C., DeLaunay, J. J., López, D. Delgado, Dembinski, H., Deoskar, K., Desai, A., Desiati, P., de Vries, K. D., de Wasseige, G., DeYoung, T., Diaz, A., Díaz-Vélez, J. C., Dittmer, M., Domi, A., Dujmovic, H., DuVernois, M. A., Ehrhardt, T., Eller, P., Engel, R., Erpenbeck, H., Evans, J., Evenson, P. A., Fan, K. L., Fazely, A. R., Fedynitch, A., Feigl, N., Fiedlschuster, S., Finley, C., Fischer, L., Fox, D., Franckowiak, A., Friedman, E., Fritz, A., Fürst, P., Gaisser, T. K., Gallagher, J., Ganster, E., Garcia, A., Garrappa, S., Gerhardt, L., Ghadimi, A., Glaser, C., Glauch, T., Glüsenkamp, T., Goehlke, N., Gonzalez, J. G., Goswami, S., Grant, D., Gray, S. J., Griffin, S., Griswold, S., Günther, C., Gutjahr, P., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Hamdaoui, H., Minh, M. Ha, Hanson, K., Hardin, J., Harnisch, A. A., Hatch, P., Haungs, A., Helbing, K., Hellrung, J., Henningsen, F., Heuermann, L., Hickford, S., Hidvegi, A., Hill, C., Hill, G. C., Hoffman, K. D., Hoshina, K., Hou, W., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., Hymon, K., In, S., Iovine, N., Ishihara, A., Jansson, M., Japaridze, G. S., Jeong, M., Jin, M., Jones, B. J. P., Kang, D., Kang, W., Kang, X., Kappes, A., Kappesser, D., Kardum, L., Karg, T., Karl, M., Karle, A., Katz, U., Kauer, M., Kelley, J. L., Kheirandish, A., Kin, K., Kiryluk, J., Klein, S. R., Kochocki, A., Koirala, R., Kolanoski, H., Kontrimas, T., Köpke, L., Kopper, C., Koskinen, D. J., Koundal, P., Kovacevich, M., Kowalski, M., Kozynets, T., Kruiswijk, K., Krupczak, E., Kumar, A., Kun, E., Kurahashi, N., Lad, N., Gualda, C. Lagunas, Lamoureux, M., Larson, M. J., Lauber, F., Lazar, J. P., Lee, J. W., DeHolton, K. Leonard, Leszczyńska, A., Lincetto, M., Liu, Q. R., Liubarska, M., Lohfink, E., Love, C., Mariscal, C. J. Lozano, Lu, L., Lucarelli, F., Ludwig, A., Luszczak, W., Lyu, Y., Ma, W. Y., Madsen, J., Mahn, K. B. M., Makino, Y., Mancina, S., Sainte, W. Marie, Mariş, I. C., Marka, S., Marka, Z., Marsee, M., Martinez-Soler, I., Maruyama, R., Mayhew, F., McElroy, T., McNally, F., Mead, J. V., Meagher, K., Mechbal, S., Medina, A., Meier, M., Meighen-Berger, S., Merckx, Y., Merten, L., Micallef, J., Mockler, D., Montaruli, T., Moore, R. W., Morii, Y., Morse, R., Moulai, M., Mukherjee, T., Naab, R., Nagai, R., Naumann, U., Necker, J., Neumann, M., Niederhausen, H., Nisa, M. U., Noell, A., Nowicki, S. C., Pollmann, A. Obertacke, Oehler, M., Oeyen, B., Olivas, A., Orsoe, R., Osborn, J., O'Sullivan, E., Pandya, H., Park, N., Parker, G. K., Paudel, E. N., Paul, L., Heros, C. Pérez de los, Peterson, J., Philippen, S., Pieper, S., Pizzuto, A., Plum, M., Popovych, Y., Rodriguez, M. Prado, Pries, B., Procter-Murphy, R., Przybylski, G. T., Raab, C., Rack-Helleis, J., Rawlins, K., Rechav, Z., Rehman, A., Reichherzer, P., Renzi, G., Resconi, E., Reusch, S., Rhode, W., Richman, M., Riedel, B., Roberts, E. J., Robertson, S., Rodan, S., Roellinghoff, G., Rongen, M., Rott, C., Ruhe, T., Ruohan, L., Ryckbosch, D., Safa, I., Saffer, J., Salazar-Gallegos, D., Sampathkumar, P., Herrera, S. E. Sanchez, Sandrock, A., Santander, M., Sarkar, S., Savelberg, J., Savina, P., Schaufel, M., Schieler, H., Schindler, S., Schlüter, B., Schmidt, T., Schneider, J., Schröder, F. G., Schumacher, L., Schwefer, G., Sclafani, S., Seckel, D., Seunarine, S., Sharma, A., Shefali, S., Shimizu, N., Silva, M., Skrzypek, B., Smithers, B., Snihur, R., Soedingrekso, J., Søgaard, A., Soldin, D., Sommani, G., Spannfellner, C., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stein, R., Stezelberger, T., Stürwald, T., Stuttard, T., Sullivan, G. W., Taboada, I., Ter-Antonyan, S., Thompson, W. G., Thwaites, J., Tilav, S., Tollefson, K., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Tung, C. F., Turcotte, R., Twagirayezu, J. P., Ty, B., Elorrieta, M. A. 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P., Yildizci, E., Yoshida, S., Yu, F., Yu, S., Yuan, T., Zhang, Z., and Zhelnin, P.
Abstract: Gamma-ray bursts (GRBs) have long been considered a possible source of high-energy neutrinos. While no correlations have yet been detected between high-energy neutrinos and GRBs, the recent observation of GRB 221009A - the brightest GRB observed by Fermi-GBM to date and the first one to be observed above an energy of 10 TeV - provides a unique opportunity to test for hadronic emission. In this paper, we leverage the wide energy range of the IceCube Neutrino Observatory to search for neutrinos from GRB 221009A. We find no significant deviation from background expectation across event samples ranging from MeV to PeV energies, placing stringent upper limits on the neutrino emission from this source., Comment: Version in ApJ Letters Focus on the Ultra-luminous Gamma-Ray Burst GRB 221009A
Published: 2023
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49. A decade of non-invasive prenatal screening in Australia: National impact on prenatal screening and diagnostic testing

Author: Hui, L, Halliday, J, Hui, L, and Halliday, J
Abstract: Prenatal screening for aneuploidy has undergone immense changes over the past two decades. In 2013 cell-free DNA-based non-invasive prenatal testing (NIPT) became a new self-funded option primarily for Down syndrome screening, but also other aneuploidies and genetic conditions. The numbers of Medicare item claims for prenatal diagnostic procedures have halved since the introduction of NIPT, while billings for serum screening fell by 40% over the same period, on a background of steady births. Australia is now observing historically low rates of prenatal diagnostic testing. These data provide an informative snapshot of historic changes in prenatal screening and diagnosis, as our sector prepares for the impending impacts of other advances in genomics on maternity care. They also highlight the need to address equity and quality issues that arise when consumers must bear the full costs of improved genomic tests in the absence of Medicare funding.
Published: 2023

50. Perinatal outcomes and genomic characteristics of fetal copy number variants: An individual record linkage study of 713 pregnancies

Author: Pynaker, C, Norris, F, Hui, L, Halliday, J, Pynaker, C, Norris, F, Hui, L, and Halliday, J
Abstract: OBJECTIVE: To determine the perinatal outcomes of fetuses diagnosed with a pathogenic copy number variant (CNV) or variant of uncertain significance (VUS); and to characterize these variants in terms of testing indication, genomic location, size, and inheritance. METHODS: Retrospective study of singleton pregnancies with a pathogenic CNV or VUS from a single laboratory during 2012-2018. Probabilistic record linkage between the prenatal diagnosis dataset and perinatal outcome data for births from 20 weeks gestation was performed. If no birth record was found, this implied a pregnancy loss <20 weeks. RESULTS: We included 6945 prenatal microarray results; a pathogenic CNV was detected in 230 (3.3%, 95% CI: 2.9%-3.8%) and a VUS in 483 (7.0%, 95% CI: 6.4%-7.6%). Of pregnancies with a pathogenic CNV, 20.0% (95% CI: 15.3%-25.6%) had a live birth, 3.0% (95% CI: 1.5%-6.2%) had a perinatal death (stillbirth or neonatal death), and 77% (95% CI: 71.1%-81.9%) had no birth record. Of those with a VUS, 64.4% (95% CI: 60.0%-68.5%) had a live birth, 1.8% (95% CI: 1.0%-3.5%) had a perinatal death, and no birth record was found for 33.7% (95% CI: 29.7%-38.1%). Most pathogenic CNVs (61.1%) were <7 Mb in size. The most common microdeletion syndromes were DiGeorge, Wolf-Hirschhorn, and Cri-du-chat syndromes. CONCLUSION: This study provides an overview of perinatal outcomes and frequency of recurrent CNVs observed in the prenatal microarray era.
Published: 2023

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